precision medicine - cancer
TRANSCRIPT
1
Precision Medicine
2
Precision medicine
3
Disease classification
4
Research strategy
5
Lung cancer
6
Worldwide cancers
7
Geographical map
8
Smoke exposure
9
Never smokers
10
Exposome
11
p53
12
Chronic inflammation and infection
13
Obesity is a chronic inflammatory disease
14
Cytokines
15
Genome
16
NSCLC evolution
17
Chemical agents
18
Three decades
19
TP53 mutations
20
TP53 mutations
21
TP53 functions
22
Three decades
23
Somatic mutations
24
Carcinogens fingerprint
25
Patient prognosis
26
Transcriptome
27
MicroRNA
28
microRNA mechanisms
29
Hypothesis
30
Upregulated microRNA
31
Increased miR-21 expression
32
miR-21 expression
33
miR-21
34
MiRNAs
35
4-gene classifier
36
Meta-Analysis
37
Mechanistic cancer biomarkers
38
miR-21 and 4 coding genes
39
Non-coding RNA
40
Proof of Principle
41
Epigenome
42
DNA methylation
43
Prognostic epigenetic signature
44
Survival curve
45
Microbiome
46
Microbiome and carcinogenesis
47
Microbiome, TP53 and lung cancer
48
Temperans challenge
49
Microbiome and immune modulation
50
Metabolome
51
Tumor metabolism
52
Urinalysis
53
Creatine ribose
54
Survival curve
55
Low dose CT screening
56
Spiral CT scans
57
Low dose CT
58
Unmet needs
59
Precision medicine goals
60
Collaborators