8/14/2019 Potential Protective Effect of Vitamin C on Carcin...[Eur J Surg Oncol. 1992] - PubMed Result

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PMID: 1318851 [PubMed - indexed for MEDLINE]

Potential protective effect of vitamin C on carcinogenesis caused by nitrosamine in drinking water: anexperimental study on Wistar rats.

Kessler H , Husemann B , Wagner W .

Surgical Hospital, University of Erlangen-Nrnberg, Germany.

In an experiment with Wistar rats the question of whether oral vitamin C application has a protective effect inliver carcinogenesis caused by N-nitrosodiethylamine in drinking water (n = 104) was studied. When comparingfour groups (without carcinogen, with carcinogen and carcinogen plus vitamin C alternately and concomitantly)significant statistical differences in the linear regression were noted. Ninety per cent of the rats developedhepatocellular carcinomas when only carcinogen was administered whereas the rate with additionaladministration of vitamin C alternately and concomitantly was 68% and 55%, respectively. Without carcinogenno tumour developed. The results suggest that vitamin C may delay the development of liver cancer upon oraladministration of N-nitrosodiethylamine. The explanation for this fact is still hypothetical.

1: Eur J Surg Oncol. 1992 Jun;18(3):275-81.

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Ascorbic Acid (Cecon Drops, Cenolate , Cevi-Bid , ...) Ascorbic acid is usedto prevent and treat scurvy, a disease caused by a lack of vitamin C in the body.