poster 69: an evaluation of corneal staining with 2 multipurpose solutions

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future studies will determine if other performance differ- ences exist. (A.R. is an employee of Alcon Research Ltd., and re- ceived grant support funded by Alcon Research Ltd.) Poster 69 An Evaluation of Corneal Staining With 2 Multipurpose Solutions Tom Kislan, O.D., Stroudsburg Eye Specialists, 29 North 9th Street, Stroudsburg, Pennsylvania 18360 Background: Recent publications suggest that different mul- tipurpose solutions are associated with varying degrees of staining and that this staining varies depending on the lens used. The purpose of this study was to evaluate corneal staining associated with 2 multipurpose contact lens solutions and various silicone hydrogel and nonsilicone hydrogel lenses. Methods: Forty-eight patients using Acuvue 2, PureVision, O 2 Optix, Oasys, or Proclear contact lenses were randomized to Opti-Free Express or RepleniSH. Corneal staining was mea- sured at 1-day postsoak and evaluated 30 minutes after lens insertion. For grading, the cornea was divided into 5 regions, and the percentage of staining in each region was recorded. Results: Both MPS produced substantial amounts of cor- neal staining. With Opti-Free Express, the mean staining area ranged from 28% with O 2 Optix to 46% with Pure- Vision. With RepleniSH, the mean staining area ranged from 14% with O 2 Optix to 33% with Oasys. Conclusion: These findings suggest that both solutions are associated with substantial corneal staining with all brands of silicone hydrogel contact lenses. (Study funded by an unrestricted grant from AMO.) Poster 70 Long-Term Results and Patient Management Factors of a Telescope Prosthesis for End-Stage AMD (The IMT002 Study) Susan A. Primo, O.D., M.P.H., Emory University School of Medicine, Department of Ophthalmology, 1365B Clifton Rd. NE, Suite B1100, Atlanta, Georgia 30322 Purpose: To evaluate long-term change in visual acuity and describe patient selection and management pearls for telescope prosthesis patients with stable bilateral end-stage AMD. The monocular device is specifically designed for the treatment of severe central vision loss associated with bilateral scotomata due to geographic atrophy or disciform scars. The investiga- tional device is currently under regulatory review seeking marketing approval in the United States. Methods: A total of 206 patients age 55 and older with bilateral scotomata due to disciform or atrophic AMD, and best-corrected visual acuity (BCVA) 20/80 to 20/800, were successfully implanted with the telescope prosthesis (IMT™ by Dr. Isaac Lipshitz, VisionCare, Saratoga, Cali- fornia). To be enrolled in this prospective, 28-center clinical trial, study patients were required to demonstrate at least a 5-letter improvement in BCVA on the ETDRS chart with an external telescope. Patients were treated and managed by a multidisciplinary team that included low vision practitio- ner(s), a retina specialist, and anterior segment surgeon. Rehabilitation visits were conducted postoperatively for 12 weeks. Outcome measures included change in BCVA and the NEI VFQ-25. Additional rehab work and evaluation were done at 3 to 4 years postimplantation. Fellow eyes served as controls. Results: Mean age was 76 years. Baseline mean distance and near BCVA were 20/312 and 20/250, respectively. At 2 years, mean distance BCVA improved 3.2 lines and mean near BCVA improved 2.9 lines. Gain of 3 lines of dis- tance BCVA occurred in 59.2% (103/173) of implanted eyes vs. 10.3% (18/174) of fellow eye controls (P.0001). Overall, 98.2% (170/173) of implanted eyes had improved or stable (no change) distance BCVA. NEI VFQ scores, tested to 1 year after implantation, a secondary outcome measure, showed relevant VFQ subscales improved 7 to 14 points. Loss of 3 lines of distance BCVA occurred in 0.6% (1/173) of implanted eyes vs. 7.5% (13/174) of fellow eyes (P.0013). There were 2 cases of corneal decompen- sation, 1 case of exudative AMD recurrence, and no cases of retinal detachment. The majority of patients continued to maintain 3 or more lines of BCVA improvement at 3 years postimplantation. The use of additional rehab work a few years out proved successful. Conclusion: Long-term results demonstrate this telescope prosthesis is effective in improving both visual acuity and quality of life in patients with end-stage AMD. Preoperative expectation management and postoperative visual rehabili- tation include specific factors related to a monocular im- plantable telephoto device. Key aspects of patient educa- tion/training include alternate eye viewing for central vs. peripheral vision activities, combination use of the tele- scope-implanted eye with near-activity low vision aids as needed, and use of eccentric view position if necessary. Multispecialty teams with ophthalmologists, low vision op- tometrists, and visual rehabilitation specialists are ideally suited to comprehensively select and rehabilitate telescope prosthesis patients. Poster 71 Goldmann Tonometer Calibration Changes Over Time Judith A. Perrigin, O.D., David M. Perrigin, O.D., and Erin S. Jacob, B.A., University of Houston, College of Optometry, 505 J. Davis Armistead Building, Houston, Texas 77204-2020 Purpose: Goldmann tonometry intraocular pressure mea- surements will be erroneous and may lead to inappropriate treatment if the instrument is not calibrated. Devices for determining accuracy of calibration are provided with each new instrument but without specific guidelines regarding frequency. The goal of our study was to investigate calibra- tion errors in a clinical setting over time. 330 Optometry, Vol 79, No 6, June 2008

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future studies will determine if other performance differ-ences exist.

(A.R. is an employee of Alcon Research Ltd., and re-ceived grant support funded by Alcon Research Ltd.)

Poster 69

An Evaluation of Corneal Staining With 2 MultipurposeSolutionsTom Kislan, O.D., Stroudsburg Eye Specialists, 29 North9th Street, Stroudsburg, Pennsylvania 18360

Background: Recent publications suggest that different mul-tipurpose solutions are associated with varying degrees ofstaining and that this staining varies depending on the lensused. The purpose of this study was to evaluate cornealstaining associated with 2 multipurpose contact lens solutionsand various silicone hydrogel and nonsilicone hydrogel lenses.Methods: Forty-eight patients using Acuvue 2, PureVision, O2

Optix, Oasys, or Proclear contact lenses were randomized toOpti-Free Express or RepleniSH. Corneal staining was mea-sured at 1-day postsoak and evaluated 30 minutes after lensinsertion. For grading, the cornea was divided into 5 regions,and the percentage of staining in each region was recorded.Results: Both MPS produced substantial amounts of cor-neal staining. With Opti-Free Express, the mean stainingarea ranged from 28% with O2 Optix to 46% with Pure-Vision. With RepleniSH, the mean staining area rangedfrom 14% with O2 Optix to 33% with Oasys.Conclusion: These findings suggest that both solutions areassociated with substantial corneal staining with all brandsof silicone hydrogel contact lenses.

(Study funded by an unrestricted grant from AMO.)

Poster 70

Long-Term Results and Patient Management Factors ofa Telescope Prosthesis for End-Stage AMD (The IMT002Study)Susan A. Primo, O.D., M.P.H., Emory University Schoolof Medicine, Department of Ophthalmology, 1365BClifton Rd. NE, Suite B1100, Atlanta, Georgia 30322

Purpose: To evaluate long-term change in visual acuity anddescribe patient selection and management pearls for telescopeprosthesis patients with stable bilateral end-stage AMD. Themonocular device is specifically designed for the treatment ofsevere central vision loss associated with bilateral scotomatadue to geographic atrophy or disciform scars. The investiga-tional device is currently under regulatory review seekingmarketing approval in the United States.Methods: A total of 206 patients age 55 and older withbilateral scotomata due to disciform or atrophic AMD, andbest-corrected visual acuity (BCVA) 20/80 to 20/800, weresuccessfully implanted with the telescope prosthesis(IMT™ by Dr. Isaac Lipshitz, VisionCare, Saratoga, Cali-fornia). To be enrolled in this prospective, 28-center clinicaltrial, study patients were required to demonstrate at least a

5-letter improvement in BCVA on the ETDRS chart with anexternal telescope. Patients were treated and managed by amultidisciplinary team that included low vision practitio-ner(s), a retina specialist, and anterior segment surgeon.Rehabilitation visits were conducted postoperatively for 12weeks. Outcome measures included change in BCVA andthe NEI VFQ-25. Additional rehab work and evaluationwere done at 3 to 4 years postimplantation. Fellow eyesserved as controls.Results: Mean age was 76 years. Baseline mean distanceand near BCVA were 20/312 and 20/250, respectively. At 2years, mean distance BCVA improved 3.2 lines and meannear BCVA improved 2.9 lines. Gain of �3 lines of dis-tance BCVA occurred in 59.2% (103/173) of implantedeyes vs. 10.3% (18/174) of fellow eye controls (P�.0001).Overall, 98.2% (170/173) of implanted eyes had improvedor stable (no change) distance BCVA. NEI VFQ scores,tested to 1 year after implantation, a secondary outcomemeasure, showed relevant VFQ subscales improved 7 to 14points. Loss of �3 lines of distance BCVA occurred in0.6% (1/173) of implanted eyes vs. 7.5% (13/174) of felloweyes (P�.0013). There were 2 cases of corneal decompen-sation, 1 case of exudative AMD recurrence, and no cases ofretinal detachment. The majority of patients continued tomaintain 3 or more lines of BCVA improvement at 3 yearspostimplantation. The use of additional rehab work a fewyears out proved successful.Conclusion: Long-term results demonstrate this telescopeprosthesis is effective in improving both visual acuity andquality of life in patients with end-stage AMD. Preoperativeexpectation management and postoperative visual rehabili-tation include specific factors related to a monocular im-plantable telephoto device. Key aspects of patient educa-tion/training include alternate eye viewing for central vs.peripheral vision activities, combination use of the tele-scope-implanted eye with near-activity low vision aids asneeded, and use of eccentric view position if necessary.Multispecialty teams with ophthalmologists, low vision op-tometrists, and visual rehabilitation specialists are ideallysuited to comprehensively select and rehabilitate telescopeprosthesis patients.

Poster 71

Goldmann Tonometer Calibration Changes Over TimeJudith A. Perrigin, O.D., David M. Perrigin, O.D., andErin S. Jacob, B.A., University of Houston, College ofOptometry, 505 J. Davis Armistead Building, Houston,Texas 77204-2020

Purpose: Goldmann tonometry intraocular pressure mea-surements will be erroneous and may lead to inappropriatetreatment if the instrument is not calibrated. Devices fordetermining accuracy of calibration are provided with eachnew instrument but without specific guidelines regardingfrequency. The goal of our study was to investigate calibra-tion errors in a clinical setting over time.

330 Optometry, Vol 79, No 6, June 2008