pathology of organels i. introductionpau.lf1.cuni.cz/file/6372/3pathorganels-introduction.pdf ·...
TRANSCRIPT
![Page 1: Pathology of Organels I. Introductionpau.lf1.cuni.cz/file/6372/3pathorganels-introduction.pdf · ATM/p53 Signaling Pathway. Ca ovarii MIB1 (Ki67) Ca ovarii p53. Lymphocyti & mesothelia](https://reader033.vdocuments.site/reader033/viewer/2022051405/5a75be977f8b9aea3e8cbd2b/html5/thumbnails/1.jpg)
General Pathology
Pathology of Organels I.
– Introduction
The Secretory
Process
and
Its DisordersInst. Pathol. ,1st Med. Faculty, Charles Univ. Prague
Jaroslava Dušková
http://pau.lf1.cuni.cz/en/texts-from-the-lectures-and-seminars-presentations
![Page 2: Pathology of Organels I. Introductionpau.lf1.cuni.cz/file/6372/3pathorganels-introduction.pdf · ATM/p53 Signaling Pathway. Ca ovarii MIB1 (Ki67) Ca ovarii p53. Lymphocyti & mesothelia](https://reader033.vdocuments.site/reader033/viewer/2022051405/5a75be977f8b9aea3e8cbd2b/html5/thumbnails/2.jpg)
Pathology of Organels I - table of contents
Cell components & their function
Pathomorphology of the cell nucleus
quantitative
qualitative
Pathomorphology of the cytoplasm
cytosol
organelles
intracellular accumulations
water
proteins
lipids
glycogen
pigments,foreign bodies
Cellular secretion
types
organelles involved
sense
![Page 3: Pathology of Organels I. Introductionpau.lf1.cuni.cz/file/6372/3pathorganels-introduction.pdf · ATM/p53 Signaling Pathway. Ca ovarii MIB1 (Ki67) Ca ovarii p53. Lymphocyti & mesothelia](https://reader033.vdocuments.site/reader033/viewer/2022051405/5a75be977f8b9aea3e8cbd2b/html5/thumbnails/3.jpg)
The Cell Components &Their Function
1. nucleus (incl. nucleolus and
nuclear envelope)
2. cytoplasm
cytoplasmic matrix
cytoplasmic organelles
3. plasma membranes
![Page 4: Pathology of Organels I. Introductionpau.lf1.cuni.cz/file/6372/3pathorganels-introduction.pdf · ATM/p53 Signaling Pathway. Ca ovarii MIB1 (Ki67) Ca ovarii p53. Lymphocyti & mesothelia](https://reader033.vdocuments.site/reader033/viewer/2022051405/5a75be977f8b9aea3e8cbd2b/html5/thumbnails/4.jpg)
Main Cell
Organelles
![Page 5: Pathology of Organels I. Introductionpau.lf1.cuni.cz/file/6372/3pathorganels-introduction.pdf · ATM/p53 Signaling Pathway. Ca ovarii MIB1 (Ki67) Ca ovarii p53. Lymphocyti & mesothelia](https://reader033.vdocuments.site/reader033/viewer/2022051405/5a75be977f8b9aea3e8cbd2b/html5/thumbnails/5.jpg)
The Cell Components &Their Function
The nucleus(incl. nucleolus and nuclear
envelope)
chromosomes
DNA, RNA, histones
![Page 6: Pathology of Organels I. Introductionpau.lf1.cuni.cz/file/6372/3pathorganels-introduction.pdf · ATM/p53 Signaling Pathway. Ca ovarii MIB1 (Ki67) Ca ovarii p53. Lymphocyti & mesothelia](https://reader033.vdocuments.site/reader033/viewer/2022051405/5a75be977f8b9aea3e8cbd2b/html5/thumbnails/6.jpg)
Nuclear envelope
with pores
![Page 7: Pathology of Organels I. Introductionpau.lf1.cuni.cz/file/6372/3pathorganels-introduction.pdf · ATM/p53 Signaling Pathway. Ca ovarii MIB1 (Ki67) Ca ovarii p53. Lymphocyti & mesothelia](https://reader033.vdocuments.site/reader033/viewer/2022051405/5a75be977f8b9aea3e8cbd2b/html5/thumbnails/7.jpg)
The Cell Components &Their Function
The nucleus functions
– cell division
– genetic information
transcription & control
![Page 8: Pathology of Organels I. Introductionpau.lf1.cuni.cz/file/6372/3pathorganels-introduction.pdf · ATM/p53 Signaling Pathway. Ca ovarii MIB1 (Ki67) Ca ovarii p53. Lymphocyti & mesothelia](https://reader033.vdocuments.site/reader033/viewer/2022051405/5a75be977f8b9aea3e8cbd2b/html5/thumbnails/8.jpg)
Cell Nucleus Pathology (1)
Related to genom changes
quantitative:
– binucleation, multinucleation – regular
polyploidy (4n, 8n… 2nn) - reactive change eg.
in inflammation –adaptation
qualitative:
– translocations, deletions, amplifications –
aneuploidy – often in neoplasms
(DNA densitometry, FISH, CGH…)
![Page 9: Pathology of Organels I. Introductionpau.lf1.cuni.cz/file/6372/3pathorganels-introduction.pdf · ATM/p53 Signaling Pathway. Ca ovarii MIB1 (Ki67) Ca ovarii p53. Lymphocyti & mesothelia](https://reader033.vdocuments.site/reader033/viewer/2022051405/5a75be977f8b9aea3e8cbd2b/html5/thumbnails/9.jpg)
Neoplasia (Tumour)
DNA disease
Stepwise accumulation
of genetic abnormalities
Escape of immunological
clearing systems
![Page 10: Pathology of Organels I. Introductionpau.lf1.cuni.cz/file/6372/3pathorganels-introduction.pdf · ATM/p53 Signaling Pathway. Ca ovarii MIB1 (Ki67) Ca ovarii p53. Lymphocyti & mesothelia](https://reader033.vdocuments.site/reader033/viewer/2022051405/5a75be977f8b9aea3e8cbd2b/html5/thumbnails/10.jpg)
Neoplasia (Tumour)
DNA disease Stepwise accumulation of genetic abnormalities
self sufficiency in growth sighnals
insensitivity to anti-growth signals
limitless replicative potential
sustained angiogenesis
tissue invasion and metastasis
Escape of immunological clearing systems
evading apoptosis
![Page 11: Pathology of Organels I. Introductionpau.lf1.cuni.cz/file/6372/3pathorganels-introduction.pdf · ATM/p53 Signaling Pathway. Ca ovarii MIB1 (Ki67) Ca ovarii p53. Lymphocyti & mesothelia](https://reader033.vdocuments.site/reader033/viewer/2022051405/5a75be977f8b9aea3e8cbd2b/html5/thumbnails/11.jpg)
L SIL
![Page 12: Pathology of Organels I. Introductionpau.lf1.cuni.cz/file/6372/3pathorganels-introduction.pdf · ATM/p53 Signaling Pathway. Ca ovarii MIB1 (Ki67) Ca ovarii p53. Lymphocyti & mesothelia](https://reader033.vdocuments.site/reader033/viewer/2022051405/5a75be977f8b9aea3e8cbd2b/html5/thumbnails/12.jpg)
CIN I
![Page 13: Pathology of Organels I. Introductionpau.lf1.cuni.cz/file/6372/3pathorganels-introduction.pdf · ATM/p53 Signaling Pathway. Ca ovarii MIB1 (Ki67) Ca ovarii p53. Lymphocyti & mesothelia](https://reader033.vdocuments.site/reader033/viewer/2022051405/5a75be977f8b9aea3e8cbd2b/html5/thumbnails/13.jpg)
p16INK4a protein
inhibitor of cyclin
dependent kinase
controled in healthy
cells – undetectable
overexpressed as a
result of HPV E7
protein
MARKER OF
DYSPLASTIC CELLS
![Page 14: Pathology of Organels I. Introductionpau.lf1.cuni.cz/file/6372/3pathorganels-introduction.pdf · ATM/p53 Signaling Pathway. Ca ovarii MIB1 (Ki67) Ca ovarii p53. Lymphocyti & mesothelia](https://reader033.vdocuments.site/reader033/viewer/2022051405/5a75be977f8b9aea3e8cbd2b/html5/thumbnails/14.jpg)
![Page 15: Pathology of Organels I. Introductionpau.lf1.cuni.cz/file/6372/3pathorganels-introduction.pdf · ATM/p53 Signaling Pathway. Ca ovarii MIB1 (Ki67) Ca ovarii p53. Lymphocyti & mesothelia](https://reader033.vdocuments.site/reader033/viewer/2022051405/5a75be977f8b9aea3e8cbd2b/html5/thumbnails/15.jpg)
![Page 16: Pathology of Organels I. Introductionpau.lf1.cuni.cz/file/6372/3pathorganels-introduction.pdf · ATM/p53 Signaling Pathway. Ca ovarii MIB1 (Ki67) Ca ovarii p53. Lymphocyti & mesothelia](https://reader033.vdocuments.site/reader033/viewer/2022051405/5a75be977f8b9aea3e8cbd2b/html5/thumbnails/16.jpg)
![Page 17: Pathology of Organels I. Introductionpau.lf1.cuni.cz/file/6372/3pathorganels-introduction.pdf · ATM/p53 Signaling Pathway. Ca ovarii MIB1 (Ki67) Ca ovarii p53. Lymphocyti & mesothelia](https://reader033.vdocuments.site/reader033/viewer/2022051405/5a75be977f8b9aea3e8cbd2b/html5/thumbnails/17.jpg)
Apoptotic bodies
![Page 18: Pathology of Organels I. Introductionpau.lf1.cuni.cz/file/6372/3pathorganels-introduction.pdf · ATM/p53 Signaling Pathway. Ca ovarii MIB1 (Ki67) Ca ovarii p53. Lymphocyti & mesothelia](https://reader033.vdocuments.site/reader033/viewer/2022051405/5a75be977f8b9aea3e8cbd2b/html5/thumbnails/18.jpg)
ATM/p53 Signaling Pathway
![Page 19: Pathology of Organels I. Introductionpau.lf1.cuni.cz/file/6372/3pathorganels-introduction.pdf · ATM/p53 Signaling Pathway. Ca ovarii MIB1 (Ki67) Ca ovarii p53. Lymphocyti & mesothelia](https://reader033.vdocuments.site/reader033/viewer/2022051405/5a75be977f8b9aea3e8cbd2b/html5/thumbnails/19.jpg)
Ca ovarii MIB1 (Ki67)
![Page 20: Pathology of Organels I. Introductionpau.lf1.cuni.cz/file/6372/3pathorganels-introduction.pdf · ATM/p53 Signaling Pathway. Ca ovarii MIB1 (Ki67) Ca ovarii p53. Lymphocyti & mesothelia](https://reader033.vdocuments.site/reader033/viewer/2022051405/5a75be977f8b9aea3e8cbd2b/html5/thumbnails/20.jpg)
Ca ovarii p53
![Page 21: Pathology of Organels I. Introductionpau.lf1.cuni.cz/file/6372/3pathorganels-introduction.pdf · ATM/p53 Signaling Pathway. Ca ovarii MIB1 (Ki67) Ca ovarii p53. Lymphocyti & mesothelia](https://reader033.vdocuments.site/reader033/viewer/2022051405/5a75be977f8b9aea3e8cbd2b/html5/thumbnails/21.jpg)
Lymphocyti &
mesothelia
Carcinosis
peritonei
![Page 22: Pathology of Organels I. Introductionpau.lf1.cuni.cz/file/6372/3pathorganels-introduction.pdf · ATM/p53 Signaling Pathway. Ca ovarii MIB1 (Ki67) Ca ovarii p53. Lymphocyti & mesothelia](https://reader033.vdocuments.site/reader033/viewer/2022051405/5a75be977f8b9aea3e8cbd2b/html5/thumbnails/22.jpg)
Pleuritis
carcinomatosa
AgNOR
Alc. Blue pH2,5
![Page 23: Pathology of Organels I. Introductionpau.lf1.cuni.cz/file/6372/3pathorganels-introduction.pdf · ATM/p53 Signaling Pathway. Ca ovarii MIB1 (Ki67) Ca ovarii p53. Lymphocyti & mesothelia](https://reader033.vdocuments.site/reader033/viewer/2022051405/5a75be977f8b9aea3e8cbd2b/html5/thumbnails/23.jpg)
![Page 24: Pathology of Organels I. Introductionpau.lf1.cuni.cz/file/6372/3pathorganels-introduction.pdf · ATM/p53 Signaling Pathway. Ca ovarii MIB1 (Ki67) Ca ovarii p53. Lymphocyti & mesothelia](https://reader033.vdocuments.site/reader033/viewer/2022051405/5a75be977f8b9aea3e8cbd2b/html5/thumbnails/24.jpg)
![Page 25: Pathology of Organels I. Introductionpau.lf1.cuni.cz/file/6372/3pathorganels-introduction.pdf · ATM/p53 Signaling Pathway. Ca ovarii MIB1 (Ki67) Ca ovarii p53. Lymphocyti & mesothelia](https://reader033.vdocuments.site/reader033/viewer/2022051405/5a75be977f8b9aea3e8cbd2b/html5/thumbnails/25.jpg)
CSF carcinosis
![Page 26: Pathology of Organels I. Introductionpau.lf1.cuni.cz/file/6372/3pathorganels-introduction.pdf · ATM/p53 Signaling Pathway. Ca ovarii MIB1 (Ki67) Ca ovarii p53. Lymphocyti & mesothelia](https://reader033.vdocuments.site/reader033/viewer/2022051405/5a75be977f8b9aea3e8cbd2b/html5/thumbnails/26.jpg)
Cell Nucleus Pathology (2)
Related to nucleolemma
quantitative:
– invaginations - pseudoinclusions
qualitative:
– thickening (irregular)
– chromatin margination
Nuclear inclusions (real)
– viral, lipids, glycogen
![Page 27: Pathology of Organels I. Introductionpau.lf1.cuni.cz/file/6372/3pathorganels-introduction.pdf · ATM/p53 Signaling Pathway. Ca ovarii MIB1 (Ki67) Ca ovarii p53. Lymphocyti & mesothelia](https://reader033.vdocuments.site/reader033/viewer/2022051405/5a75be977f8b9aea3e8cbd2b/html5/thumbnails/27.jpg)
Cytoplasmic nuclear pseudoinclusions
![Page 28: Pathology of Organels I. Introductionpau.lf1.cuni.cz/file/6372/3pathorganels-introduction.pdf · ATM/p53 Signaling Pathway. Ca ovarii MIB1 (Ki67) Ca ovarii p53. Lymphocyti & mesothelia](https://reader033.vdocuments.site/reader033/viewer/2022051405/5a75be977f8b9aea3e8cbd2b/html5/thumbnails/28.jpg)
papillary ca of thyroid
![Page 29: Pathology of Organels I. Introductionpau.lf1.cuni.cz/file/6372/3pathorganels-introduction.pdf · ATM/p53 Signaling Pathway. Ca ovarii MIB1 (Ki67) Ca ovarii p53. Lymphocyti & mesothelia](https://reader033.vdocuments.site/reader033/viewer/2022051405/5a75be977f8b9aea3e8cbd2b/html5/thumbnails/29.jpg)
![Page 30: Pathology of Organels I. Introductionpau.lf1.cuni.cz/file/6372/3pathorganels-introduction.pdf · ATM/p53 Signaling Pathway. Ca ovarii MIB1 (Ki67) Ca ovarii p53. Lymphocyti & mesothelia](https://reader033.vdocuments.site/reader033/viewer/2022051405/5a75be977f8b9aea3e8cbd2b/html5/thumbnails/30.jpg)
grooves
![Page 31: Pathology of Organels I. Introductionpau.lf1.cuni.cz/file/6372/3pathorganels-introduction.pdf · ATM/p53 Signaling Pathway. Ca ovarii MIB1 (Ki67) Ca ovarii p53. Lymphocyti & mesothelia](https://reader033.vdocuments.site/reader033/viewer/2022051405/5a75be977f8b9aea3e8cbd2b/html5/thumbnails/31.jpg)
HPV - koilocytes
![Page 32: Pathology of Organels I. Introductionpau.lf1.cuni.cz/file/6372/3pathorganels-introduction.pdf · ATM/p53 Signaling Pathway. Ca ovarii MIB1 (Ki67) Ca ovarii p53. Lymphocyti & mesothelia](https://reader033.vdocuments.site/reader033/viewer/2022051405/5a75be977f8b9aea3e8cbd2b/html5/thumbnails/32.jpg)
Cytomegalovirus
![Page 33: Pathology of Organels I. Introductionpau.lf1.cuni.cz/file/6372/3pathorganels-introduction.pdf · ATM/p53 Signaling Pathway. Ca ovarii MIB1 (Ki67) Ca ovarii p53. Lymphocyti & mesothelia](https://reader033.vdocuments.site/reader033/viewer/2022051405/5a75be977f8b9aea3e8cbd2b/html5/thumbnails/33.jpg)
Cowdry A inclusion – herpetic encephalitis
![Page 34: Pathology of Organels I. Introductionpau.lf1.cuni.cz/file/6372/3pathorganels-introduction.pdf · ATM/p53 Signaling Pathway. Ca ovarii MIB1 (Ki67) Ca ovarii p53. Lymphocyti & mesothelia](https://reader033.vdocuments.site/reader033/viewer/2022051405/5a75be977f8b9aea3e8cbd2b/html5/thumbnails/34.jpg)
glycogen nuclei
![Page 35: Pathology of Organels I. Introductionpau.lf1.cuni.cz/file/6372/3pathorganels-introduction.pdf · ATM/p53 Signaling Pathway. Ca ovarii MIB1 (Ki67) Ca ovarii p53. Lymphocyti & mesothelia](https://reader033.vdocuments.site/reader033/viewer/2022051405/5a75be977f8b9aea3e8cbd2b/html5/thumbnails/35.jpg)
The Cell Components &Their Function
ribosomes
endoplasmic
reticulum
Golgi complex
lysosomes
peroxisomes
mitochondria
cytoskeleton
caveolae
The cytoplasm (cytosol)cytoplasmic matrix
cytoplasmic organelles
![Page 36: Pathology of Organels I. Introductionpau.lf1.cuni.cz/file/6372/3pathorganels-introduction.pdf · ATM/p53 Signaling Pathway. Ca ovarii MIB1 (Ki67) Ca ovarii p53. Lymphocyti & mesothelia](https://reader033.vdocuments.site/reader033/viewer/2022051405/5a75be977f8b9aea3e8cbd2b/html5/thumbnails/36.jpg)
The Cell Components &Their Function
The cytoplasm (cytosol)aqueous solution with enzymes
![Page 37: Pathology of Organels I. Introductionpau.lf1.cuni.cz/file/6372/3pathorganels-introduction.pdf · ATM/p53 Signaling Pathway. Ca ovarii MIB1 (Ki67) Ca ovarii p53. Lymphocyti & mesothelia](https://reader033.vdocuments.site/reader033/viewer/2022051405/5a75be977f8b9aea3e8cbd2b/html5/thumbnails/37.jpg)
The Cell Components &Their Function
The cytoplasm function
– proteosynthesis (in coop. with organelles)
– storage unit (fat, carbohydrates and
secretory vesicles)
![Page 38: Pathology of Organels I. Introductionpau.lf1.cuni.cz/file/6372/3pathorganels-introduction.pdf · ATM/p53 Signaling Pathway. Ca ovarii MIB1 (Ki67) Ca ovarii p53. Lymphocyti & mesothelia](https://reader033.vdocuments.site/reader033/viewer/2022051405/5a75be977f8b9aea3e8cbd2b/html5/thumbnails/38.jpg)
Intracellular Accumulations
water –hydropic degeneration
proteins – hyaline droplets
lipids – steatosis
glycogen – glycogenosis
pigments – melanin, ceroid, lipofuscin,
hemosiderin
foreign bodies, crystals
microorganisms
![Page 39: Pathology of Organels I. Introductionpau.lf1.cuni.cz/file/6372/3pathorganels-introduction.pdf · ATM/p53 Signaling Pathway. Ca ovarii MIB1 (Ki67) Ca ovarii p53. Lymphocyti & mesothelia](https://reader033.vdocuments.site/reader033/viewer/2022051405/5a75be977f8b9aea3e8cbd2b/html5/thumbnails/39.jpg)
Hydropic Degeneration
intoxications
sepsis
anoxia
starvation
functional overload
autolysis
ENERGY DEFICIENCY
![Page 40: Pathology of Organels I. Introductionpau.lf1.cuni.cz/file/6372/3pathorganels-introduction.pdf · ATM/p53 Signaling Pathway. Ca ovarii MIB1 (Ki67) Ca ovarii p53. Lymphocyti & mesothelia](https://reader033.vdocuments.site/reader033/viewer/2022051405/5a75be977f8b9aea3e8cbd2b/html5/thumbnails/40.jpg)
![Page 41: Pathology of Organels I. Introductionpau.lf1.cuni.cz/file/6372/3pathorganels-introduction.pdf · ATM/p53 Signaling Pathway. Ca ovarii MIB1 (Ki67) Ca ovarii p53. Lymphocyti & mesothelia](https://reader033.vdocuments.site/reader033/viewer/2022051405/5a75be977f8b9aea3e8cbd2b/html5/thumbnails/41.jpg)
![Page 42: Pathology of Organels I. Introductionpau.lf1.cuni.cz/file/6372/3pathorganels-introduction.pdf · ATM/p53 Signaling Pathway. Ca ovarii MIB1 (Ki67) Ca ovarii p53. Lymphocyti & mesothelia](https://reader033.vdocuments.site/reader033/viewer/2022051405/5a75be977f8b9aea3e8cbd2b/html5/thumbnails/42.jpg)
Intracellular Accumulations
water –hydropic degeneration
proteins – hyaline droplets
lipids – steatosis
glycogen – glycogenosis
pigments – melanin, ceroid, lipofuscin,
hemosiderin
foreign bodies, crystals
microorganisms
![Page 43: Pathology of Organels I. Introductionpau.lf1.cuni.cz/file/6372/3pathorganels-introduction.pdf · ATM/p53 Signaling Pathway. Ca ovarii MIB1 (Ki67) Ca ovarii p53. Lymphocyti & mesothelia](https://reader033.vdocuments.site/reader033/viewer/2022051405/5a75be977f8b9aea3e8cbd2b/html5/thumbnails/43.jpg)
![Page 44: Pathology of Organels I. Introductionpau.lf1.cuni.cz/file/6372/3pathorganels-introduction.pdf · ATM/p53 Signaling Pathway. Ca ovarii MIB1 (Ki67) Ca ovarii p53. Lymphocyti & mesothelia](https://reader033.vdocuments.site/reader033/viewer/2022051405/5a75be977f8b9aea3e8cbd2b/html5/thumbnails/44.jpg)
Intracellular Accumulations
water –hydropic degeneration
proteins – hyaline droplets
lipids – steatosis
glycogen – glycogenosis
pigments – melanin, ceroid, lipofuscin,
hemosiderin
foreign bodies, crystals
microorganisms
![Page 45: Pathology of Organels I. Introductionpau.lf1.cuni.cz/file/6372/3pathorganels-introduction.pdf · ATM/p53 Signaling Pathway. Ca ovarii MIB1 (Ki67) Ca ovarii p53. Lymphocyti & mesothelia](https://reader033.vdocuments.site/reader033/viewer/2022051405/5a75be977f8b9aea3e8cbd2b/html5/thumbnails/45.jpg)
Steatosis myocardii (oil red)
![Page 46: Pathology of Organels I. Introductionpau.lf1.cuni.cz/file/6372/3pathorganels-introduction.pdf · ATM/p53 Signaling Pathway. Ca ovarii MIB1 (Ki67) Ca ovarii p53. Lymphocyti & mesothelia](https://reader033.vdocuments.site/reader033/viewer/2022051405/5a75be977f8b9aea3e8cbd2b/html5/thumbnails/46.jpg)
Adenoma corticis glandulae suprarenalis
![Page 47: Pathology of Organels I. Introductionpau.lf1.cuni.cz/file/6372/3pathorganels-introduction.pdf · ATM/p53 Signaling Pathway. Ca ovarii MIB1 (Ki67) Ca ovarii p53. Lymphocyti & mesothelia](https://reader033.vdocuments.site/reader033/viewer/2022051405/5a75be977f8b9aea3e8cbd2b/html5/thumbnails/47.jpg)
![Page 48: Pathology of Organels I. Introductionpau.lf1.cuni.cz/file/6372/3pathorganels-introduction.pdf · ATM/p53 Signaling Pathway. Ca ovarii MIB1 (Ki67) Ca ovarii p53. Lymphocyti & mesothelia](https://reader033.vdocuments.site/reader033/viewer/2022051405/5a75be977f8b9aea3e8cbd2b/html5/thumbnails/48.jpg)
Intracellular Accumulations
water –hydropic degeneration
proteins – hyaline droplets
lipids – steatosis
glycogen – glycogenosis
pigments – melanin, ceroid, lipofuscin,
hemosiderin
foreign bodies, crystals
microorganisms
![Page 49: Pathology of Organels I. Introductionpau.lf1.cuni.cz/file/6372/3pathorganels-introduction.pdf · ATM/p53 Signaling Pathway. Ca ovarii MIB1 (Ki67) Ca ovarii p53. Lymphocyti & mesothelia](https://reader033.vdocuments.site/reader033/viewer/2022051405/5a75be977f8b9aea3e8cbd2b/html5/thumbnails/49.jpg)
PAS
![Page 50: Pathology of Organels I. Introductionpau.lf1.cuni.cz/file/6372/3pathorganels-introduction.pdf · ATM/p53 Signaling Pathway. Ca ovarii MIB1 (Ki67) Ca ovarii p53. Lymphocyti & mesothelia](https://reader033.vdocuments.site/reader033/viewer/2022051405/5a75be977f8b9aea3e8cbd2b/html5/thumbnails/50.jpg)
Intracellular Accumulations
water –hydropic degeneration
proteins – hyaline droplets
lipids – steatosis
glycogen – glycogenosis
pigments – melanin, ceroid, lipofuscin,
hemosiderin
foreign bodies, crystals
microorganisms
![Page 51: Pathology of Organels I. Introductionpau.lf1.cuni.cz/file/6372/3pathorganels-introduction.pdf · ATM/p53 Signaling Pathway. Ca ovarii MIB1 (Ki67) Ca ovarii p53. Lymphocyti & mesothelia](https://reader033.vdocuments.site/reader033/viewer/2022051405/5a75be977f8b9aea3e8cbd2b/html5/thumbnails/51.jpg)
Melanoma
![Page 52: Pathology of Organels I. Introductionpau.lf1.cuni.cz/file/6372/3pathorganels-introduction.pdf · ATM/p53 Signaling Pathway. Ca ovarii MIB1 (Ki67) Ca ovarii p53. Lymphocyti & mesothelia](https://reader033.vdocuments.site/reader033/viewer/2022051405/5a75be977f8b9aea3e8cbd2b/html5/thumbnails/52.jpg)
Ceroid - pseudomelanosis intestini crassi
![Page 53: Pathology of Organels I. Introductionpau.lf1.cuni.cz/file/6372/3pathorganels-introduction.pdf · ATM/p53 Signaling Pathway. Ca ovarii MIB1 (Ki67) Ca ovarii p53. Lymphocyti & mesothelia](https://reader033.vdocuments.site/reader033/viewer/2022051405/5a75be977f8b9aea3e8cbd2b/html5/thumbnails/53.jpg)
HEHS
![Page 54: Pathology of Organels I. Introductionpau.lf1.cuni.cz/file/6372/3pathorganels-introduction.pdf · ATM/p53 Signaling Pathway. Ca ovarii MIB1 (Ki67) Ca ovarii p53. Lymphocyti & mesothelia](https://reader033.vdocuments.site/reader033/viewer/2022051405/5a75be977f8b9aea3e8cbd2b/html5/thumbnails/54.jpg)
![Page 55: Pathology of Organels I. Introductionpau.lf1.cuni.cz/file/6372/3pathorganels-introduction.pdf · ATM/p53 Signaling Pathway. Ca ovarii MIB1 (Ki67) Ca ovarii p53. Lymphocyti & mesothelia](https://reader033.vdocuments.site/reader033/viewer/2022051405/5a75be977f8b9aea3e8cbd2b/html5/thumbnails/55.jpg)
Haemosiderosis hepatis
![Page 56: Pathology of Organels I. Introductionpau.lf1.cuni.cz/file/6372/3pathorganels-introduction.pdf · ATM/p53 Signaling Pathway. Ca ovarii MIB1 (Ki67) Ca ovarii p53. Lymphocyti & mesothelia](https://reader033.vdocuments.site/reader033/viewer/2022051405/5a75be977f8b9aea3e8cbd2b/html5/thumbnails/56.jpg)
Intracellular Accumulations
water –hydropic degeneration
proteins – hyaline droplets
lipids – steatosis
glycogen – glycogenosis
pigments – melanin, ceroid, lipofuscin,
hemosiderin
foreign bodies, crystals
microorganisms
![Page 57: Pathology of Organels I. Introductionpau.lf1.cuni.cz/file/6372/3pathorganels-introduction.pdf · ATM/p53 Signaling Pathway. Ca ovarii MIB1 (Ki67) Ca ovarii p53. Lymphocyti & mesothelia](https://reader033.vdocuments.site/reader033/viewer/2022051405/5a75be977f8b9aea3e8cbd2b/html5/thumbnails/57.jpg)
Asbestosis
![Page 58: Pathology of Organels I. Introductionpau.lf1.cuni.cz/file/6372/3pathorganels-introduction.pdf · ATM/p53 Signaling Pathway. Ca ovarii MIB1 (Ki67) Ca ovarii p53. Lymphocyti & mesothelia](https://reader033.vdocuments.site/reader033/viewer/2022051405/5a75be977f8b9aea3e8cbd2b/html5/thumbnails/58.jpg)
Sinus pilonides
![Page 59: Pathology of Organels I. Introductionpau.lf1.cuni.cz/file/6372/3pathorganels-introduction.pdf · ATM/p53 Signaling Pathway. Ca ovarii MIB1 (Ki67) Ca ovarii p53. Lymphocyti & mesothelia](https://reader033.vdocuments.site/reader033/viewer/2022051405/5a75be977f8b9aea3e8cbd2b/html5/thumbnails/59.jpg)
Intracellular Accumulations
water –hydropic degeneration
proteins – hyaline droplets
lipids – steatosis
glycogen – glycogenosis
pigments – melanin, ceroid, lipofuscin,
hemosiderin
foreign bodies, crystals
microorganisms
![Page 60: Pathology of Organels I. Introductionpau.lf1.cuni.cz/file/6372/3pathorganels-introduction.pdf · ATM/p53 Signaling Pathway. Ca ovarii MIB1 (Ki67) Ca ovarii p53. Lymphocyti & mesothelia](https://reader033.vdocuments.site/reader033/viewer/2022051405/5a75be977f8b9aea3e8cbd2b/html5/thumbnails/60.jpg)
Cytomegalovirus inclusions in the GER
![Page 61: Pathology of Organels I. Introductionpau.lf1.cuni.cz/file/6372/3pathorganels-introduction.pdf · ATM/p53 Signaling Pathway. Ca ovarii MIB1 (Ki67) Ca ovarii p53. Lymphocyti & mesothelia](https://reader033.vdocuments.site/reader033/viewer/2022051405/5a75be977f8b9aea3e8cbd2b/html5/thumbnails/61.jpg)
Chlamydia
![Page 62: Pathology of Organels I. Introductionpau.lf1.cuni.cz/file/6372/3pathorganels-introduction.pdf · ATM/p53 Signaling Pathway. Ca ovarii MIB1 (Ki67) Ca ovarii p53. Lymphocyti & mesothelia](https://reader033.vdocuments.site/reader033/viewer/2022051405/5a75be977f8b9aea3e8cbd2b/html5/thumbnails/62.jpg)
The Cell Components &Their Function
ribosomes
endoplasmic
reticulum
Golgi complex
lysosomes
peroxisomes
mitochondria
cytoskeleton
caveolae
vaults
The cytoplasm -cytoplasmic organelles
![Page 63: Pathology of Organels I. Introductionpau.lf1.cuni.cz/file/6372/3pathorganels-introduction.pdf · ATM/p53 Signaling Pathway. Ca ovarii MIB1 (Ki67) Ca ovarii p53. Lymphocyti & mesothelia](https://reader033.vdocuments.site/reader033/viewer/2022051405/5a75be977f8b9aea3e8cbd2b/html5/thumbnails/63.jpg)
The Cytoplasmic Organelles Functions (1)
Organelle Composition Function
ribosomes RNA –protein
complexes
proteosynthesis
endoplasmic
reticulum
cisternae,tubular
channels
proteosynthesis
& transport
Golgi complex
(GC)
smooth
membranes &
vesicles
processing and
packaging
lysosomes sacklike GC
derived
digestion
![Page 64: Pathology of Organels I. Introductionpau.lf1.cuni.cz/file/6372/3pathorganels-introduction.pdf · ATM/p53 Signaling Pathway. Ca ovarii MIB1 (Ki67) Ca ovarii p53. Lymphocyti & mesothelia](https://reader033.vdocuments.site/reader033/viewer/2022051405/5a75be977f8b9aea3e8cbd2b/html5/thumbnails/64.jpg)
GC
ER
N
![Page 65: Pathology of Organels I. Introductionpau.lf1.cuni.cz/file/6372/3pathorganels-introduction.pdf · ATM/p53 Signaling Pathway. Ca ovarii MIB1 (Ki67) Ca ovarii p53. Lymphocyti & mesothelia](https://reader033.vdocuments.site/reader033/viewer/2022051405/5a75be977f8b9aea3e8cbd2b/html5/thumbnails/65.jpg)
Autophagosomes
![Page 66: Pathology of Organels I. Introductionpau.lf1.cuni.cz/file/6372/3pathorganels-introduction.pdf · ATM/p53 Signaling Pathway. Ca ovarii MIB1 (Ki67) Ca ovarii p53. Lymphocyti & mesothelia](https://reader033.vdocuments.site/reader033/viewer/2022051405/5a75be977f8b9aea3e8cbd2b/html5/thumbnails/66.jpg)
![Page 67: Pathology of Organels I. Introductionpau.lf1.cuni.cz/file/6372/3pathorganels-introduction.pdf · ATM/p53 Signaling Pathway. Ca ovarii MIB1 (Ki67) Ca ovarii p53. Lymphocyti & mesothelia](https://reader033.vdocuments.site/reader033/viewer/2022051405/5a75be977f8b9aea3e8cbd2b/html5/thumbnails/67.jpg)
The Cytoplasmic Organelles Functions (2)
Organelle Composition Function
peroxisomes lysosomes like
producing or
using H2O2
detoxication
mitochondria membrane
bound energy
production
Oxydative
fosforylation, cell
signaling, pH
control, Ca
homeostasis
![Page 68: Pathology of Organels I. Introductionpau.lf1.cuni.cz/file/6372/3pathorganels-introduction.pdf · ATM/p53 Signaling Pathway. Ca ovarii MIB1 (Ki67) Ca ovarii p53. Lymphocyti & mesothelia](https://reader033.vdocuments.site/reader033/viewer/2022051405/5a75be977f8b9aea3e8cbd2b/html5/thumbnails/68.jpg)
Oncocytus
![Page 69: Pathology of Organels I. Introductionpau.lf1.cuni.cz/file/6372/3pathorganels-introduction.pdf · ATM/p53 Signaling Pathway. Ca ovarii MIB1 (Ki67) Ca ovarii p53. Lymphocyti & mesothelia](https://reader033.vdocuments.site/reader033/viewer/2022051405/5a75be977f8b9aea3e8cbd2b/html5/thumbnails/69.jpg)
MGG
HE
Oncocytes
![Page 70: Pathology of Organels I. Introductionpau.lf1.cuni.cz/file/6372/3pathorganels-introduction.pdf · ATM/p53 Signaling Pathway. Ca ovarii MIB1 (Ki67) Ca ovarii p53. Lymphocyti & mesothelia](https://reader033.vdocuments.site/reader033/viewer/2022051405/5a75be977f8b9aea3e8cbd2b/html5/thumbnails/70.jpg)
Oncocytes
![Page 71: Pathology of Organels I. Introductionpau.lf1.cuni.cz/file/6372/3pathorganels-introduction.pdf · ATM/p53 Signaling Pathway. Ca ovarii MIB1 (Ki67) Ca ovarii p53. Lymphocyti & mesothelia](https://reader033.vdocuments.site/reader033/viewer/2022051405/5a75be977f8b9aea3e8cbd2b/html5/thumbnails/71.jpg)
The Biology and the Genetics of Hürthle Cell Tumors of the Thyroid
Máximo V et al, Endocrine-Related Cancer, 2012, 19, R131-R147
• Hürthle cell appearance - a phenotype superimposed on the
genotypic and conventional histopathologic features of the
tumors.
• large deletions of mitochondrial DNA (mtDNA), mutations of
mtDNA genes and nuclear genes coding for OXPHOS proteins
• energy production defects in Hürthle cell tumors;
• the increased proliferation of mitochondria a compensatory
mechanism
• predisposition for necrosis instead of apoptosis which seems to
be blocked in most Hürthle cell tumors.
![Page 72: Pathology of Organels I. Introductionpau.lf1.cuni.cz/file/6372/3pathorganels-introduction.pdf · ATM/p53 Signaling Pathway. Ca ovarii MIB1 (Ki67) Ca ovarii p53. Lymphocyti & mesothelia](https://reader033.vdocuments.site/reader033/viewer/2022051405/5a75be977f8b9aea3e8cbd2b/html5/thumbnails/72.jpg)
The biology and the genetics of Hürthle cell tumors of the thyroid
Máximo V et al, Endocrine-Related Cancer, 2012, 19, R131-R147
![Page 73: Pathology of Organels I. Introductionpau.lf1.cuni.cz/file/6372/3pathorganels-introduction.pdf · ATM/p53 Signaling Pathway. Ca ovarii MIB1 (Ki67) Ca ovarii p53. Lymphocyti & mesothelia](https://reader033.vdocuments.site/reader033/viewer/2022051405/5a75be977f8b9aea3e8cbd2b/html5/thumbnails/73.jpg)
Peroxisomes - microbodiesup to 2 microns - catalase
FunctionDegradation: substrate oxidation
(etanol)
Anabolism: synthesis of
prostaglandin , cholesterol,
billiary acids, plasmalogens,
gluconeogenesis,
transamination
![Page 74: Pathology of Organels I. Introductionpau.lf1.cuni.cz/file/6372/3pathorganels-introduction.pdf · ATM/p53 Signaling Pathway. Ca ovarii MIB1 (Ki67) Ca ovarii p53. Lymphocyti & mesothelia](https://reader033.vdocuments.site/reader033/viewer/2022051405/5a75be977f8b9aea3e8cbd2b/html5/thumbnails/74.jpg)
The Cytoplasmic Organelles Functions (3)
Organelle Composition Function
Cytoskeleton Microtubules & actin
microfilaments
Microvilli, cilia,
flagella
Caveolae Membrane
indentationsShuttling
material
Vaults Octagonal barrrels
like
ribonucleoproteins
Shuttling
molecules
![Page 75: Pathology of Organels I. Introductionpau.lf1.cuni.cz/file/6372/3pathorganels-introduction.pdf · ATM/p53 Signaling Pathway. Ca ovarii MIB1 (Ki67) Ca ovarii p53. Lymphocyti & mesothelia](https://reader033.vdocuments.site/reader033/viewer/2022051405/5a75be977f8b9aea3e8cbd2b/html5/thumbnails/75.jpg)
![Page 76: Pathology of Organels I. Introductionpau.lf1.cuni.cz/file/6372/3pathorganels-introduction.pdf · ATM/p53 Signaling Pathway. Ca ovarii MIB1 (Ki67) Ca ovarii p53. Lymphocyti & mesothelia](https://reader033.vdocuments.site/reader033/viewer/2022051405/5a75be977f8b9aea3e8cbd2b/html5/thumbnails/76.jpg)
Trichomonas vaginalis
![Page 77: Pathology of Organels I. Introductionpau.lf1.cuni.cz/file/6372/3pathorganels-introduction.pdf · ATM/p53 Signaling Pathway. Ca ovarii MIB1 (Ki67) Ca ovarii p53. Lymphocyti & mesothelia](https://reader033.vdocuments.site/reader033/viewer/2022051405/5a75be977f8b9aea3e8cbd2b/html5/thumbnails/77.jpg)
carcinoma
Mesothelioma
Mesothelioma
![Page 78: Pathology of Organels I. Introductionpau.lf1.cuni.cz/file/6372/3pathorganels-introduction.pdf · ATM/p53 Signaling Pathway. Ca ovarii MIB1 (Ki67) Ca ovarii p53. Lymphocyti & mesothelia](https://reader033.vdocuments.site/reader033/viewer/2022051405/5a75be977f8b9aea3e8cbd2b/html5/thumbnails/78.jpg)
Cilia
![Page 79: Pathology of Organels I. Introductionpau.lf1.cuni.cz/file/6372/3pathorganels-introduction.pdf · ATM/p53 Signaling Pathway. Ca ovarii MIB1 (Ki67) Ca ovarii p53. Lymphocyti & mesothelia](https://reader033.vdocuments.site/reader033/viewer/2022051405/5a75be977f8b9aea3e8cbd2b/html5/thumbnails/79.jpg)
The Cell Components &Their Function
The plasma membranes– cell surrounding
– organelles enclosing
– bilayer of lipids and proteins
![Page 80: Pathology of Organels I. Introductionpau.lf1.cuni.cz/file/6372/3pathorganels-introduction.pdf · ATM/p53 Signaling Pathway. Ca ovarii MIB1 (Ki67) Ca ovarii p53. Lymphocyti & mesothelia](https://reader033.vdocuments.site/reader033/viewer/2022051405/5a75be977f8b9aea3e8cbd2b/html5/thumbnails/80.jpg)
alc. blue pH2,5
![Page 81: Pathology of Organels I. Introductionpau.lf1.cuni.cz/file/6372/3pathorganels-introduction.pdf · ATM/p53 Signaling Pathway. Ca ovarii MIB1 (Ki67) Ca ovarii p53. Lymphocyti & mesothelia](https://reader033.vdocuments.site/reader033/viewer/2022051405/5a75be977f8b9aea3e8cbd2b/html5/thumbnails/81.jpg)
Cell
mechanismMembrane function
Structure Compartmentalization, cytoskeleton & ER
contacts, fluid & electrolyte balance
Protection Barrier to toxins & foreign organisms/cells
Activation of
cell
Hormones, mitogens, antigens, growth
&proliferation factors
Storage Receptors, transport, diffusion, exocytosis,
endocytosis
Cell to cell
interaction
Communication & attachment –junctional
complexes, nutritive relationship, enzymes
and antibody release
![Page 82: Pathology of Organels I. Introductionpau.lf1.cuni.cz/file/6372/3pathorganels-introduction.pdf · ATM/p53 Signaling Pathway. Ca ovarii MIB1 (Ki67) Ca ovarii p53. Lymphocyti & mesothelia](https://reader033.vdocuments.site/reader033/viewer/2022051405/5a75be977f8b9aea3e8cbd2b/html5/thumbnails/82.jpg)
Estrogen
receptors
![Page 83: Pathology of Organels I. Introductionpau.lf1.cuni.cz/file/6372/3pathorganels-introduction.pdf · ATM/p53 Signaling Pathway. Ca ovarii MIB1 (Ki67) Ca ovarii p53. Lymphocyti & mesothelia](https://reader033.vdocuments.site/reader033/viewer/2022051405/5a75be977f8b9aea3e8cbd2b/html5/thumbnails/83.jpg)
Carcinoma mammae ductale invasivum IDC
HE PRER
MIB1 e-cadherin c-erbB2 / Her2-neu
![Page 84: Pathology of Organels I. Introductionpau.lf1.cuni.cz/file/6372/3pathorganels-introduction.pdf · ATM/p53 Signaling Pathway. Ca ovarii MIB1 (Ki67) Ca ovarii p53. Lymphocyti & mesothelia](https://reader033.vdocuments.site/reader033/viewer/2022051405/5a75be977f8b9aea3e8cbd2b/html5/thumbnails/84.jpg)
Secretion
– exocrine (apical pole of the cell lumen, duct)
– endocrine (basal pole of the cell blood)
– paracrine influencing neighbouring cells
– autocrine self influencing
![Page 85: Pathology of Organels I. Introductionpau.lf1.cuni.cz/file/6372/3pathorganels-introduction.pdf · ATM/p53 Signaling Pathway. Ca ovarii MIB1 (Ki67) Ca ovarii p53. Lymphocyti & mesothelia](https://reader033.vdocuments.site/reader033/viewer/2022051405/5a75be977f8b9aea3e8cbd2b/html5/thumbnails/85.jpg)
Organelles Involved in Secretion
membrane type
maternal origin (ovum cytoplasm)
autoreplicative
– granular (rough) endoplasmic reticulum
– Golgi apparatus
– lysosomes
![Page 86: Pathology of Organels I. Introductionpau.lf1.cuni.cz/file/6372/3pathorganels-introduction.pdf · ATM/p53 Signaling Pathway. Ca ovarii MIB1 (Ki67) Ca ovarii p53. Lymphocyti & mesothelia](https://reader033.vdocuments.site/reader033/viewer/2022051405/5a75be977f8b9aea3e8cbd2b/html5/thumbnails/86.jpg)
Exocytosis and Its Disorders
protein secretion on the granular
endoplasmic reticulum
cis Golgi network
trans Golgi network (signal molecules
attachment)
Golgi Endoplasmic Reticulum
Lysosomes
![Page 87: Pathology of Organels I. Introductionpau.lf1.cuni.cz/file/6372/3pathorganels-introduction.pdf · ATM/p53 Signaling Pathway. Ca ovarii MIB1 (Ki67) Ca ovarii p53. Lymphocyti & mesothelia](https://reader033.vdocuments.site/reader033/viewer/2022051405/5a75be977f8b9aea3e8cbd2b/html5/thumbnails/87.jpg)
![Page 88: Pathology of Organels I. Introductionpau.lf1.cuni.cz/file/6372/3pathorganels-introduction.pdf · ATM/p53 Signaling Pathway. Ca ovarii MIB1 (Ki67) Ca ovarii p53. Lymphocyti & mesothelia](https://reader033.vdocuments.site/reader033/viewer/2022051405/5a75be977f8b9aea3e8cbd2b/html5/thumbnails/88.jpg)
Secretion
continual - permanent -unregulated
pulsatory - regulated
![Page 89: Pathology of Organels I. Introductionpau.lf1.cuni.cz/file/6372/3pathorganels-introduction.pdf · ATM/p53 Signaling Pathway. Ca ovarii MIB1 (Ki67) Ca ovarii p53. Lymphocyti & mesothelia](https://reader033.vdocuments.site/reader033/viewer/2022051405/5a75be977f8b9aea3e8cbd2b/html5/thumbnails/89.jpg)
Secretion
continual - permanent– unregulated vesicle transport
– protocolagen, proteoglycans, viral
particles
Targetting:immunoglobulins without and after stimulation
![Page 90: Pathology of Organels I. Introductionpau.lf1.cuni.cz/file/6372/3pathorganels-introduction.pdf · ATM/p53 Signaling Pathway. Ca ovarii MIB1 (Ki67) Ca ovarii p53. Lymphocyti & mesothelia](https://reader033.vdocuments.site/reader033/viewer/2022051405/5a75be977f8b9aea3e8cbd2b/html5/thumbnails/90.jpg)
C
o
ll
a
g
e
n
p
r
o
d
u
c
ti
o
n
![Page 91: Pathology of Organels I. Introductionpau.lf1.cuni.cz/file/6372/3pathorganels-introduction.pdf · ATM/p53 Signaling Pathway. Ca ovarii MIB1 (Ki67) Ca ovarii p53. Lymphocyti & mesothelia](https://reader033.vdocuments.site/reader033/viewer/2022051405/5a75be977f8b9aea3e8cbd2b/html5/thumbnails/91.jpg)
Secretion pulsatory - regulated
– exocrine mucin or zymogen granules secretion
– endocrine cells– neurons– T-lymphocytes– heparinocytes– thrombocytes– granulocytes
– endothelia
membrane budding
coating proteins
![Page 92: Pathology of Organels I. Introductionpau.lf1.cuni.cz/file/6372/3pathorganels-introduction.pdf · ATM/p53 Signaling Pathway. Ca ovarii MIB1 (Ki67) Ca ovarii p53. Lymphocyti & mesothelia](https://reader033.vdocuments.site/reader033/viewer/2022051405/5a75be977f8b9aea3e8cbd2b/html5/thumbnails/92.jpg)
![Page 93: Pathology of Organels I. Introductionpau.lf1.cuni.cz/file/6372/3pathorganels-introduction.pdf · ATM/p53 Signaling Pathway. Ca ovarii MIB1 (Ki67) Ca ovarii p53. Lymphocyti & mesothelia](https://reader033.vdocuments.site/reader033/viewer/2022051405/5a75be977f8b9aea3e8cbd2b/html5/thumbnails/93.jpg)
![Page 94: Pathology of Organels I. Introductionpau.lf1.cuni.cz/file/6372/3pathorganels-introduction.pdf · ATM/p53 Signaling Pathway. Ca ovarii MIB1 (Ki67) Ca ovarii p53. Lymphocyti & mesothelia](https://reader033.vdocuments.site/reader033/viewer/2022051405/5a75be977f8b9aea3e8cbd2b/html5/thumbnails/94.jpg)
Secretion Disordersdefects of synthesis product itself
auxilliary proteins
retention in GER(inborn endoplasmic reticulum storage
diseases)
hyaline droplets (Russel bodies)
![Page 95: Pathology of Organels I. Introductionpau.lf1.cuni.cz/file/6372/3pathorganels-introduction.pdf · ATM/p53 Signaling Pathway. Ca ovarii MIB1 (Ki67) Ca ovarii p53. Lymphocyti & mesothelia](https://reader033.vdocuments.site/reader033/viewer/2022051405/5a75be977f8b9aea3e8cbd2b/html5/thumbnails/95.jpg)
Sinusitis chronica
![Page 96: Pathology of Organels I. Introductionpau.lf1.cuni.cz/file/6372/3pathorganels-introduction.pdf · ATM/p53 Signaling Pathway. Ca ovarii MIB1 (Ki67) Ca ovarii p53. Lymphocyti & mesothelia](https://reader033.vdocuments.site/reader033/viewer/2022051405/5a75be977f8b9aea3e8cbd2b/html5/thumbnails/96.jpg)
Autophagosomes
![Page 97: Pathology of Organels I. Introductionpau.lf1.cuni.cz/file/6372/3pathorganels-introduction.pdf · ATM/p53 Signaling Pathway. Ca ovarii MIB1 (Ki67) Ca ovarii p53. Lymphocyti & mesothelia](https://reader033.vdocuments.site/reader033/viewer/2022051405/5a75be977f8b9aea3e8cbd2b/html5/thumbnails/97.jpg)
Neuroendocrine
Secretion Disorders
defects of synthesis product itself
auxilliary proteins
regulation disorders on the receptor level
![Page 98: Pathology of Organels I. Introductionpau.lf1.cuni.cz/file/6372/3pathorganels-introduction.pdf · ATM/p53 Signaling Pathway. Ca ovarii MIB1 (Ki67) Ca ovarii p53. Lymphocyti & mesothelia](https://reader033.vdocuments.site/reader033/viewer/2022051405/5a75be977f8b9aea3e8cbd2b/html5/thumbnails/98.jpg)
Neuroendocrine Secretion
dense core granules
secretory vesicles
(small synaptic vesicles)
![Page 99: Pathology of Organels I. Introductionpau.lf1.cuni.cz/file/6372/3pathorganels-introduction.pdf · ATM/p53 Signaling Pathway. Ca ovarii MIB1 (Ki67) Ca ovarii p53. Lymphocyti & mesothelia](https://reader033.vdocuments.site/reader033/viewer/2022051405/5a75be977f8b9aea3e8cbd2b/html5/thumbnails/99.jpg)
Membrane Componentsof Secretory Granules and Vesicles
– Synaptophysin (synaptic vesicle protein)
– Neuron Specific Enolase
– S-100 protein
identification of neuroendocrine
neoplasms
![Page 100: Pathology of Organels I. Introductionpau.lf1.cuni.cz/file/6372/3pathorganels-introduction.pdf · ATM/p53 Signaling Pathway. Ca ovarii MIB1 (Ki67) Ca ovarii p53. Lymphocyti & mesothelia](https://reader033.vdocuments.site/reader033/viewer/2022051405/5a75be977f8b9aea3e8cbd2b/html5/thumbnails/100.jpg)
calcitonin
chromogranin
Carcinoma medullare gl. thyeoideae
![Page 101: Pathology of Organels I. Introductionpau.lf1.cuni.cz/file/6372/3pathorganels-introduction.pdf · ATM/p53 Signaling Pathway. Ca ovarii MIB1 (Ki67) Ca ovarii p53. Lymphocyti & mesothelia](https://reader033.vdocuments.site/reader033/viewer/2022051405/5a75be977f8b9aea3e8cbd2b/html5/thumbnails/101.jpg)
![Page 102: Pathology of Organels I. Introductionpau.lf1.cuni.cz/file/6372/3pathorganels-introduction.pdf · ATM/p53 Signaling Pathway. Ca ovarii MIB1 (Ki67) Ca ovarii p53. Lymphocyti & mesothelia](https://reader033.vdocuments.site/reader033/viewer/2022051405/5a75be977f8b9aea3e8cbd2b/html5/thumbnails/102.jpg)
Juxtacrine Secretion (?) /Signaling
contact (- dependent) signalling
cell adhesion (inflammatory cells… neoplastic cells…
transmitted via oligosaccharide, lipid, or protein
components of a cell membrane
Unlike other types of cell signaling (such as paracrine
and endocrine), juxtacrine signaling requires physical
contact between the two cells involved.
Juxtacrine signaling has been observed for some
growth factors, cytokine and chemokine cellular
signals.
pathology of INFLAMMATION,
TUMOURS
![Page 103: Pathology of Organels I. Introductionpau.lf1.cuni.cz/file/6372/3pathorganels-introduction.pdf · ATM/p53 Signaling Pathway. Ca ovarii MIB1 (Ki67) Ca ovarii p53. Lymphocyti & mesothelia](https://reader033.vdocuments.site/reader033/viewer/2022051405/5a75be977f8b9aea3e8cbd2b/html5/thumbnails/103.jpg)