pankreas
DESCRIPTION
medTRANSCRIPT
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KELENJAR PANKREAS
FUNGSI EKSOKRIN :
- ACINI
FUNGSI ENDOKRIN :
- P.LANGERHANS
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PERCOBAAN :
- ALLOXAN, URIC ACID, HIALURIC ACID
MERUSAK SEL ß
(MERUSAK JUGA HEPAR DAN GINJAL)
- STREPTOZOTOCIN : DIABETOGENIC
MERUSAK SEL ß (RUSAK GINJAL)
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- COBALT : DEGRANULASI DAN
VACUOLISASI SEL
SEKRESI GLUKAGON KURANG
- “ORAL HYPOGLYCEMIC AGENTS”
SULFONAMID (“INSULIN SUBSTITUTE”)
TOLBUTAMID, BIGUANIDE
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I. GLUKAGON
DIHASILKAN SEL HIPERGLIKEMIK HORMON
EFEK GLUKAGON
* AKUT : GLIKOGENOLITIK
* SETELAH BEBERAPA SAAT (MENIT/JAM) :
GLUKONEOGENESIS
* LIPOLISIS : ADENIL SIKLASE SEL LEMAK
* MERANGSANG SEL ß
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* KEKUATAN JANTUNG
* SEKRESI EMPEDU
* MENGHAMBAT SEKRESI ASAM
LAMBUNG
* PENGATURAN SEKRESI
- ASAM AMINO (ALANIN - ARGININ)
SELULER ENERGI UNTUK SINTESA
PROTEIN
- EKSERSAIS
MENCEGAH TURUNNYA GULA DARAH
`
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II. INSULIN
SINTESA :
TRANSLASI : PRE PRO HORMON
PRO INSULIN
INSULIN
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EFEK :
1. METABOLISME K.H.
HEPAR :
OTOT : METABOLISME
USUS HEPAR
GULA DARAH
GINJAL ENERGI OTOT LEMAK
GLIKOGEN
URINE
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MENURUNNYA GULA DARAH
“ FATSPARER ”
- METABOLISME : PENGGUNAAN GULA
- PEMBENTUKAN GLIKOGEN
- TRANSPORT GULA KE DALAM SEL
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2. METABOLISME LEMAK
- SINTESA
- TRANSPORT GULA KE
JARINGAN LEMAK
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3. METABOLISME PROTEIN
- SINTESA
- MENGHAMBAT KATABOLISME
- MENGHAMBAT GLUKONEOGENESIS
DI HEPAR
- PERTUMBUHAN : SINERGIS DENGAN
GROWTH HORMON
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PENGATURAN SEKRESSI INSULIN
1. GULA DARAH
2. ASAM AMINO
3. HORMON GASTRO INTESTINAL GASTRIN,
SEKRETIN
4. HORMON : GLUKAGON, G.H, CORTISOL
ESTROGEN, PROGESTERON
5. NERVUS PARASIMPATIS
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SEKRESI INSULIN
DIRANGSANG DIHAMBAT
GLUKOSA EPINEFRIN
FRUKTOSA NOREPINEFRIN
ASAM AMINO D-MANOHEPTULOSA
GLUKAGON 2 DEOXYGLUCOSE
SULFONYLUREA DIAZOXIDE
3’5’ CYCLIC AMP VAGOTOMY
SEKRETIN
PAN KREOZYMIN
RANGSANGAN VAGUS
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GLUKAGON
INAKTIF AKTIF-PO4
FOSFORILASE
GLIKOGEN GLUKOSA
GLIKAGON
SINTETASE
AKTIF INAKTIF-PO4
INSULIN
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EPINEFRIN GLUKAGON
R R
SEL HEPAR MEMBRAN PLASMA
ATP
CAMP
PROTEIN KINASE
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INAKTIF AKTIF
FOSFORILASE b FOSFORILASE b
KINASE KINASE
FOSFORILASE-b FOSFORILASE- a
GLIKOGEN GLIKOSE I.FOSF
GLUKOSE
INTERNAL EKTRASE DARAH
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SOMATOSTATIN
DIHASILKAN SEL DELTA :
POLIPEPTID
1. GULA DARAH MENINGGI
2. ASAM AMINO MENINGGI
3. ASAM LEMAK MENINGGI
4. HORMON GI.TRACT MENINGGI
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EFEK :
1. MENGHAMBAT INSULIN DAN GLUKAGON
2. MENGURANGI PERGERAKAN LAMBUNG,
DUODENUM, KANDUNG EMPEDU.
3. MENGHAMBAT SEKRESI DAN ABSORPSI
SALURAN PENCERNAAN
MENGHAMBAT ASIMILASI MAKANAN
DARI USUS
GROWTH HORMONE
INHIBITARY HORMONE
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PENGARUH KEKURANGAN INSULIN
1. METABOLISME KARBOHIDRAT
TERGANGGU
- PENINGGIAN GULA DARAH
- GANGGUAN PENGGANAAN KH
- MENURUNNYA TRANSPORY
GLUKOSA KEDALAM SEL
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2. GANGGUAN TERHADAP METABOLISME
PROTEIN
- KATABOLISME PROTEIN MENINGKAT
- SINTESA PROTEIN TERHENTI
- MENINGKATNYA ASAM AMINO DLM
DARAH
- GLUKONEOGENESIS
- PROTEIN SEBAGAI SUMBER ENERGI
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3. GANGGUAN METABOLISME TERHADAP LEMAK
- MENINGKATNYA METABOLISME LEMAK
- LIPOLISIS (LIPASE)
- MENINGKATNYA ASAM LEMAK BEBAS,
GLISEROL DALAM DARAH
- PENGGUNAAN LEMAK SEBAGAI SUMBER
ENERGI (ASISDOSIS)
- MENINGKATNYA SINTESA KOLESTEROL
DAN FOSFOLIPID OLEH HEPAR
- MENINGKATNYA LIPOPROTEIN DLM DARAH
------> ATHEROSKLEROSIS