Pain Management Devices Market Forecast 2014-2024

Future Prospects for Leading Companies

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Contents

1.1 Global Pain Management Devices Market Overview

1.2 Global Pain Management Devices Market Segmentation

1.3 Why You Should Read This Report

1.4 How This Report Delivers

1.5 Key Questions Answered by This Analytical Report

1.6 Who is This Report For?

1.7 Methodology

1.8 Frequently Asked Questions (FAQ)

1.9 Associated Reports

1.10 About Visiongain

2.1 Pain: A Sensory And Emotional Phenomenon

2.1.1 Pain: A Short History

2.1.2 Pain Pathways And The Origin Of Pain

2.2 The World Health Organisation (WHO) Pain Ladder

2.2.1 Classification Of Pain

2.2.1.1 Acute Pain

2.2.1.2 Chronic Pain

2.3 The Psychosocial Effects Of Chronic Pain

2.3.1 Chronic Cancer Pain

2.3.2 Neuropathic Pain

2.3.3 Identifying Neuropathic Pain

2.4 The Neurochemistry Of Pain

2.4.1 Prostaglandins

2.4.2 Opioids

2.5 Pain Management – A Brief Overview

1. Report Overview

2. An Introduction to Pain and Pain Management

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Contents

2.6 Pain Management Drugs

2.6.1 The Use Of Opioids In Pain Management

2.6.2 OTC Pain Relievers

2.7 Pain Management Devices

2.7.1 Radiofrequency Ablation Devices

2.7.2 Analgesic Pumps

2.7.2.1 Types Of Infusion

2.7.2.2 Advantages And Disadvantages Of Infusion Pumps

2.7.3 Intradiscal Electrothermal Therapy

2.7.4 Neurostimulation

2.7.4.1 Spinal Cord Stimulation

2.7.4.2 Deep Brain Stimulation

2.7.4.3 Occipital Nerve Stimulation

2.7.5 Microcurrent Electrical Neuromuscular Stimulation

2.7.6 Transcutaneous Electrical Nerve Stimulation

2.8 Medical Devices Classification Systems

2.8.1 The US Medical Devices Classification System

2.8.2 The EU Medical Devices Classification System

2.9 Regulation Of Medical Devices

2.9.1 The US Approval And Regulation System

2.9.2 The EU Approval And Regulation System

2.9.2.1 Post-Marketing Surveillance In The EU

2.10 Market Definition

3.1 The Global Pain Management Market In 2013

3.2 Pain Management Devices: Global Market Overview

3. The Global Pain Management Devices Market: By Device Type,

2014-2024

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Contents

3.2.1 The Global Pain Management Devices Market In 2013

3.2.2 Global Pain Management Devices: Market Forecast 2014-2024

3.2.3 Changing Market Shares By Sector 2014-2024

3.3 Analgesia Infusion Pumps Market 2014-2024

3.3.1 Intrathecal Drug Delivery Systems

3.3.2 Patient Controlled Analgesia

3.3.2.1 Costs And Benefits Of PCA Pumps

3.3.2.2 PCA Pumps: Leading Products, 2014

3.3.3 Analgesia Infusion Pumps: Market Forecast 2014-2024

3.4 Spinal Cord Stimulation Market 2014-2024

3.4.1 Spinal Cord Stimulation: Leading Products, 2014

3.4.2 Spinal Cord Stimulation For Pain Management: Market Forecast 2014-2024

3.5 Radiofrequency Ablation Market 2014-2024

3.5.1 Radiofrequency Ablation for Pain Management: Leading Products, 2014

3.5.2 Radiofrequency Ablation for Pain Management: Market Forecast 2014-2024

3.6 Intradiscal Electrothermal Therapy 2014-2024

3.6.1 Intradiscal Electrothermal Therapy for Pain Management: Market Forecast 2014-2024

3.7 Transcutaneous Electrical Nerve Stimulation 2014-2024

3.7.1 Transcutaneous Electrical Nerve Stimulation: Leading Products, 2014

3.7.2 Transcutaneous Electrical Nerve Stimulation For Pain Management: Market Forecast

2014-2024

3.8 Microcurrent Electrical Neuromuscular Stimulation 2014-2024

3.8.1 Microcurrent Electrical Neuromuscular Stimulation For Pain Management: Market

Forecast 2014-2024

3.9 Other Pain Management Devices 2014-2024

3.9.1 Occipital Nerve Stimulation As A Pain Management Therapy

3.9.2 Deep Brain Stimulation As A Pain Management Therapy

3.9.3 Other Pain Management Devices: Market Forecast 2014-2024

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Contents

4.1 Chronic Pain: Variable Causes And Related Conditions

4.2 Pain Management Devices: Applications and Uses

4.2.1 Pain Management Devices Market By Application In 2013

4.2.2 Global Pain Management Devices By Application: Market Forecast 2014-2024

4.2.3 Changing Market Shares By Application 2014-2024

4.3 Musculoskeletal Pain Management Devices Market 2014-2024

4.3.1 Musculoskeletal Pain Management Devices: Leading Products, 2014

4.3.2 Musculoskeletal Pain Management Devices: Market Forecast 2014-2024

4.4 Cancer Pain Management Devices Market 2014-2024

4.4.1 Cancer Pain Management Devices: Leading Products, 2014

4.4.2 Cancer Pain Management Devices: Market Forecast 2014-2024

4.5 Migraine and Facial Pain Management Devices Market 2014-2024

4.5.1 Migraine Relieving Techniques

4.5.2 Migraine Pain Management Devices: Leading Products, 2014

4.5.3 Migraine And Facial Pain Management Devices: Market Forecast 2014-2024

4.6 Neuropathic Pain Management Devices Market 2014-2024

4.6.1 Neuropathic Pain Management Devices: Leading Products, 2014

4.6.2 Neuropathic Pain Management Devices: Market Forecast 2014-2024

4.7 Surgical And Trauma Pain Management Devices Market 2014-2024

4.7.1 Surgical And Trauma Pain Management Devices: Leading Products, 2014

4.7.2 Surgical And Trauma Pain Management Devices: Market Forecast 2014-2024

4.8 The Market For Other Pain Management Devices 2014-2024

4.8.1 The Market For Other Pain Management Devices: Market Forecast 2014-2024

4. The Global Pain Management Devices Market: By Application,

2014-2024

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Contents

5.1 The Pain Management Devices Market By Region

5.1.1 The Global Distribution Of Pain Management Devices In 2013

5.2 Leading National Markets: Forecast, 2014-2024

5.2.1 Changing Market Shares By Region, 2014-2024

5.3 Regional Pain Management Devices Markets: Analysis and Forecasts, 2014-2024

5.4 United States: The Largest Pain Management Devices Market

5.5 The EU5 Markets

5.5.1 EU5 Markets: Changing Market Shares by Country, 2014-2024

5.5.2 Germany: Fiscal Austerity Programs And Spending Cuts Impacting Market Growth

5.5.3 France: Price Reductions And Lowering Consumption Are Concerns For Market

Growth

5.5.4 UK: Private Patient Income Will Help To Offset Low Funding Levels

5.5.5 Italy: Restrictions On The Use Of Analgesic Drugs To Help Boost Pain Devices

5.5.6 Spain: Rationalisation Of Health And Pharmaceutical Expenditure Limiting Market

Growth

5.6 China: Shifting Technological Landscape Will Drive Market Growth

5.7 Japan: An Ageing Population Coupled With The Fear Of Opioid Addiction Will Stimulate Pain

Devices Uptake

5.8 India: Rising Pain Incidence And Improving Socio-Economic Conditions

5.9 South Korea: Universal Healthcare Coverage And Government Investment Fuelling Market

Growth

5.10 Russia: Improving Market Penetration For Pain Devices

5.11 Brazil: Inadequate Infrastructure Limiting Expansion

5.12 Mexico: Heavy Regulation Of Opioid Use To Strengthen Device Uptake

5.13 Rest Of The World

5. Leading National Pain Management Devices Markets 2014-2024

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Contents

6.1 Pain Management Devices – A Diversified Market

6.2 BioDelivery Sciences International (BDSI)

6.2.1 BDSI - The BEMA Technology Platform

6.2.2 BDSI: Historical Revenue Analysis, 2009-2013

6.3 Boston Scientific

6.3.1 Boston Scientific: Revenue Analysis, 2013

6.3.2 Boston Scientific - Precision And Precision Spectra Spinal Cord Stimulation Systems

6.3.3 GUIDE DBS And Enspire DBS Systems - Intelect Medical/Boston Scientific

6.4 Cephalon (Teva Pharmaceuticals)

6.4.1 Cephalon’s Pain Management Products

6.4.1.1 Actiq – Cephalon’s Therapy For Cancer Pain

6.5 DJO Global (Empi Inc)

6.5.1 Empi Inc

6.5.2 Empi’s Electrotherapy Products

6.5.3 Empi’s Iontophoresis Patch Systems

6.6 Endo Pharmaceuticals

6.6.1 Endo Pharmaceuticals: Historical Revenue Analysis, 2011-2013

6.6.2 Endo Pharmaceuticals Pain Management – Lidoderm

6.7 Hospira

6.7.1 Hospira: Historical Revenue Analysis, 2009-2013

6.7.2 Hospira - LifeCare PCA Infusion System

6.8 Kimberly-Clark Health Care

6.8.1 Kimberly-Clark: Revenue Analysis

6.8.2 Kimberly-Clark’s Cooled Radiofrequency System for Chronic Pain Relief

6.9 Medtronic

6.9.1 Medtronic: Historical Revenue Analysis, 2013-2014

6. Leading Companies in the Pain Management Devices Market,

2014

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Contents

6.9.2 Medtronic Pain Management Products

6.9.2.1 RestoreSensor Neurostimulator

6.9.2.2 RestoreUltra Neurostimulator

6.9.2.3 SynchroMed II Drug Pump

6.10 Pain Management Technologies Inc

6.10.1 Pain Management Technologies Inc’s Products

6.11 St Jude Medical

6.11.1 St Jude Medical: Historical Revenue Analysis, 2009-2013

6.11.2 St Jude Medical: Pain Management Products

6.11.3 Axium Neurostimulator System – SJM and Spinal Modulation

7.1 Peripheral Nerve Stimulation – Pipeline Products

7.1.1 Altius System High Frequency Nerve Block (Neuros Medical)

7.1.2 MicroStim System (MicroTransponder Inc)

7.1.3 Senza SCS System (Nevro Corporation)

7.2 Analgesic Infusion Systems – Pipeline Products

7.2.1 Programmable Implantable DDS (Palyon Medical Corporation)

7.2.2 Zalviso (AcelRx Pharmaceuticals)

7.3 Occipital Nerve Stimulation – Pipeline Products

7.3.1 Precision System (Boston Scientific)

7.4 Radiofrequency Ablation – Pipeline Products

7.4.1 Intracept (Relievant Medsystems Inc)

8.1 SWOT Analysis Of The Pain Management Devices Market, 2014-2024

8.1.1 Strengths

7. Pain Management Devices: R&D Pipeline 2014-2024

8. Qualitative Analysis of the Pain Management Devices Market,

2014-2024

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Contents

8.1.1.1 Cost Effectiveness: A Central Driver For Growth

8.1.1.2 Positive Side Effect Profile Of Pain Management Devices Compared With

Pain Relieving Drugs

8.1.2 Weaknesses

8.1.2.1 Short Term Pain Relief

8.1.2.2 Mechanisms Of Action Not Fully Understood

8.1.2.3 Lack Of Evidence To Support The Efficacy And Safety Of Some Therapies

8.1.2.4 Devices Failing In Clinical Trials

8.1.2.5 Education In Pain Management Is A Key Unmet Need

8.1.3 Opportunities

8.1.3.1 Expanding Disease Indications Driving Neurostimulation for Pain Relief

8.1.3.2 The Potential Of Personalised Medicine

8.1.3.3 Expansion Into Emerging Markets

8.1.3.4 Ageing Population – Growth Driver For Pain Management

8.1.4 Threats

8.1.4.1 Increasing Regulatory And Pricing Scrutiny

8.1.4.2 Medical Device Excise Tax: A Drain On Innovation?

8.1.4.3 Inadequate Reimbursement Levels Limits Potential Of Pain Devices

8.2 Porter’s Five Force Analysis Of The Pain Management Device Market

8.2.1 Threat Of Substitutes: High

8.2.2 Power Of Suppliers: Medium

8.2.3 Rivalry Among Competitors: Medium

8.2.4 Bargaining Power Of Buyers: High

8.2.5 Threat Of New Entrants: Medium

9.1 Interview With Dr Deepak Kotak, Executive Vice President, BioElectronics Corporation

9.1.1 Pain Management Devices: Market Stratification And Brief History

9.1.2 On The Direct And Related Costs Of Pain And Pain Management

9. Expert Opinions

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Contents

9.1.3 BioElectronics’ Products – FDA Approvals And The Quest For OTC Status

9.1.4 BioElectronic’s Product Distribution Partnerships And Entry Into The Advanced

Wound Care Markets

9.1.5 On The Future Plans For Product Launch

9.1.6 The Issue Of Efficacy And Healthcare Economics And Their Impact On Pain

Management Devices

9.1.7 On Future Technological Developments – Vagal Nerve And Trigeminal Nerve

Stimulation

9.1.8 On The Future Challenges And Opportunities Facing Pain Management Devices Over

The Next Decade

9.2 Interview With Penney Cowan, Chief Executive Officer, American Chronic Pain Association

9.2.1 On The Current State Of The Pain Management Devices Market

9.2.2 Socio-Political Influences On Pain Management Device And The Current Trends In The

Market

9.2.3 ACPA’s Role In Patient Empowerment And Pain Management

9.2.4 ACPA’s Corporate Strategy And Future Plans

9.2.5 On The Misconceptions Surrounding Pain And Pain Management

9.2.6 On Factors That Will Affect Future Technology Developments In Pain Management

9.2.7 Interdisciplinary Pain Management As An Opportunity For Market Growth

10.1 Market Overview

10.2 Commercial Drivers For Pain Management Devices

10.3 Neuromodulation Looks Set For High Growth

10.4 Rising Demand From Musculoskeletal Pain Will Drive Market Growth

10.5 Leading Developers Of Pain Management Devices

10.6 Growth Concentrated In The Developed Markets Of North America And Europe

10.7 Future Prospects For Pain Management Devices

10. Conclusion

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Pain Management Devices Market Forecast 2014-2024: Future Prospects for Leading Companies

Figure 3.10 Analgesia Infusion Pumps Market: Market Forecast ($m, AGR%), 2013-

2024

Table 3.9 Analgesia Infusion Pumps Market: Market Forecast ($m, AGR%, CAGR%),

2013-2024

2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 Analgesia Infusion

pumps ($m)1125.0 1181.3 1240.3 1302.3 1380.5 1477.1 1580.5 1659.5 1759.1 1864.6 2013.8 2174.9

AGR (%) 5.0 5.0 5.0 6.0 7.0 7.0 5.0 6.0 6.0 8.0 8.0CAGR (%) 2013-18CAGR (%) 2013-24

5.6 2018-24 6.76.2

A number of novel pain relieving medications are currently in the pipeline. Many of these drugs

may be reformulated in the long run for use with infusion pumps. As will many of the currently

available narcotics and pain relieving drugs. There are growth opportunities in the emerging

economies that still rely on gravity infusions, which do not meet the precision level of the infusion

pumps. Improvements in the healthcare infrastructure in these developing regions will drive the

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2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 2023 2024

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Source: Visiongain 2014

Source: Visiongain 2014

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Pain Management Devices Market Forecast 2014-2024: Future Prospects for Leading Companies

stimulation (PENS) is geared towards controlling refractory neuropathic pain. This procedure is

similar to TENS, but it involves the insertion of electrode needles underneath the skin. The inserted

needles are connected to a stimulator device with the appropriate settings. As procedures such as

this begin to gain popularity and acceptance, visiongain forecasts the market for neuropathic pain

management devices to continue its growth to 2024, when the market will reach $1178.0m, with

CAGR of 10.7% between 2018 and 2024 (Table 4.13 and Figure 4.13).

Figure 4.13 Neuropathic Pain Management Devices Market: Market Forecast ($m,

AGR%), 2013-2024

Table 4.13 Neuropathic Pain Management Devices Market: Market Forecast ($m, AGR%,

CAGR%), 2013-2024

2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 2023 2024

Neuropathic ($m) 434.8 469.6 507.2 542.7 586.1 638.9 696.4 755.5 831.1 922.5 1042.4 1178.0AGR (%) 8.0 8.0 7.0 8.0 9.0 9.0 8.5 10.0 11.0 13.0 13.0CAGR (%) 2013-18CAGR (%) 2013-24

8.0 2018-24 10.79.5

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Source: Visiongain 2014

Source: Visiongain 2014

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Pain Management Devices Market Forecast 2014-2024: Future Prospects for Leading Companies

Table 5.11 The German Pain Management Devices Market Forecast: Revenue ($m),

Market Rank, Market Share (%) and CAGR (%), 2013-2024

2013 2018 2024Market Size ($m) 255.1 351.1 569.4Global Market Ranking 2nd 2nd 3rdEU5 Market Share (%) 31.6 31.0 29.9

2013-2024 CAGR (%)Market Outlook

2013-20247.6

Positive

Germany remains the biggest exporter of medical devices in Europe. This capability coupled with

the improving economic conditions being witnessed in certain Western European countries

including Germany will aid the growth of the pain management devices market in Germany.

Visiongain forecasts this market to rise from $255.1m in 2013, to $569.4m in 2018, with CAGR of

7.6% between 2013 and 2024 (Table 5.12 and Figure 5.16). Germany remains an attractive export

market to innovative drug and device developers. The market has witnessed a recent boost in the

manufacturing of drugs and devices geared towards acute conditions such as rheumatoid arthritis,

cancer, and multiple sclerosis. Germany also remains a major market for therapies used in the

treatment of chronic conditions such as diabetes and cardiovascular diseases, due to the rise in

the ageing population being seen across Western Europe in general. Visiongain notes that these

factors will play a role in boosting sales of pain management devices in Germany over the forecast

period.

Table 5.12 The German Pain Management Devices Market: Market Forecast ($m,

AGR%, CAGR%), 2013-2024

2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 2023 2024

German Market ($m)

255.1 271.6 287.9 305.2 326.6 351.1 377.4 401.9 436.1 477.5 522.5 569.4

AGR (%) 6.5 6.0 6.0 7.0 7.5 7.5 6.5 8.5 9.5 9.4 9.0CAGR (%) 2013-18CAGR (%) 2013-24

6.6 2018-24 8.47.6

Source: Visiongain 2014

Source: Visiongain 2014