organising team - european...

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Organising Team

This workshop has been organized by the European Commission, DG RTD, Unit F5 -Health Biotechnology & Systems Biology.

Hereinafter is the list of EU-officials involved in the organisation of this event:

Dr. Arnd Hoeveler Head of Unit [email protected]. Bernard Mulligan Deputy Head of Unit [email protected]. Christina Kyriakopoulou Scientific Officer [email protected]. Antoine Mialhe Project Officer [email protected]. Margherita Bertuola Assistant [email protected]. Caroline Richmond Assistant [email protected]

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Table of content

Concept of the workshop p.4

Agenda p.5

Template questionnaire submitted to experts p.7

List of invited experts p.9

EC staff p.11

FP6 funded projects in Systems Biology p.12

FP7 funded projects in Systems Biology p.16

Notes p.24

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Concept of the workshop

Recent years have seen the rapid emergence of systems biology as a new discipline. In the biomedical sciences this trend is very apparent as research moves from a reductionist approach to a "systems biology" paradigm that attempts to understand biology and pathophysiology in an integrative manner, making use of the rapidly increasing amounts of novel (-omics) data that are becoming available.

However, despite the spectacular advances in the post-genomic era, there exists a significant chiasm between experimental data and medical knowledge, and even a greater gap when we evaluate “new knowledge” in terms of clinical utility and patients’benefit.

As a result, despite major technological advances, there are still obstacles that separate systems biology from medical applications. Systems medicine, a newly emerging scientific area, has as its aim the bridging this gap by identifying key challenges for the translation of systems biology to medicine and the clinic.

The present workshop brings together experts in a wide range of relevant disciplines from clinical, diagnostics and pharmaceutical areas, to high throughput –omicstechnologies, and computational and systems biology. Representatives of national funding agencies are also participating.

With approximately 35 participants, the workshop expects to explore opportunities and challenges for the development of the new discipline of systems medicine. Before the workshop, by means of a short free text questionnaire, the participants have been asked to identify key areas for action in the short/medium and long term at the European level to make systems medicine a reality.

The workshop will be concluded with a “Funders’ session,” where the current activities and plans in systems biology/medicine of the Member States and the EC will be presented.

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09:00 Arrival and registration of participants- Coffee

10:00 - 10.30 Welcome and Introduction10:05 Welcome & introduction – Dr. Arnd Hoeveler, Head of unit F5- Health Biotechnology10:15 Objectives of the Workshop – Dr. Christina Kyriakopoulou, Scientific officer

10.30 - 12.30 Session 1- State-of-the-Art of Systems Biology applications in MedicineChair: Dr. Adriano Henney

10:30 Introductory presentation including preliminary analysis of the questionnaires’ response, by Chair, Dr. Adriano HenneyQ1: Systems medicine definitionQ2: Contribution of SB to medicine – Success stories so far Q3: National/international research programmes in SB relevant to medicine

Success stories of systems biology for the direct benefit to medicine 10.50 “Systems biology approach to the personalization of cancer chronotherapeutics”,

Prof. Francis Levi11:00 “Modelling approaches for understanding of the mechanisms of pathogenesis and disease

progression of Creutzfeld-Jakob disease”, Dr. Francois Iris11:10 “Systems Approaches to Parkinson’s Disease”, Prof. Peter Wellstead11:20 Discussion on session 1

12:30 - 13.30 Lunch Break

13:30 - 17.30 Session 2- Analysis of Systems Biology/Systems Medicine LandscapeChairs: Prof. Olaf Wolkenhauer, Prof. Walter Kolch

13:30 Introductory presentation including preliminary analysis of the questionnaires’ response by Chair, Prof. Olaf WolkenhauerQ4: Strengths, Opportunities, Weaknesses, BottlenecksQ5: Required infrastructureQ6: Key tools to make Systems medicine a reality

13:50 "Technologies for systems medicine" by chair, Prof. Walter Kolch14:00 Discussion on session 215:30 – 16.00 Coffee Break

16:00 – 17.30 Continued discussion on session 2 and preliminary conclusion of the 1st day

20:00 Dinner (Optional and at your own expenses)

Agenda

Monday, 14 June 2010

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09:00 – 12.30 Session 3- The Way Forward09:00 Chairs: Prof. David Harrison, Dr. Adriano Henney

Introductory presentation including preliminary analysis of the questionnaires’ responseQ7: Main strategic scientific areas in systems medicine in short, medium, long termQ8: Other policy actions to develop the field of Systems medicineQ9: Areas for International collaborationQ10: Research opportunities for SMEsQ11: Research opportunities for Industries/Pharma

09:20 Discussion on session 310:30 – 11.00 Coffee Break11:00 Continued discussion on session 3

12:30 - 13.30 Lunch Break

13:30 – 16.30 Session 4- Funding bodies' discussionChairs: Dr. Arnd Hoeveler, Dr. Bernard Mulligan

13:30 "Results of the last Systems Biology EC call-Lessons to learn", Dr. Bernard Mulligan13:40 "Health Collaborative research: Funding mechanisms", Dr. Arnd Hoeveler13:50 “System biology initiatives for medical applications", Dr. Hella Lichtenberg,

representative of BMBF14:00 “System biology funding", Dr. Tom Foulkes, MRC representative14:10 "A bridge between biology and medicine“, Luxemburg Centre for Systems

Biomedicine, Prof. Rudi Balling

14:20 Discussion on session 415:00 – 15.30 Coffee Break

15:30-16:30 Conclusions

Summary conclusions of sessions 1,2,3,4 by Chairs (Adriano Henney, Walter Kolch, David Harrison, Arnd Hoeveler)

Workshop follow-up- Publication of executive (Bernard Mulligan, Christina Kyriakopoulou)

16:30 End of workshop

AgendaTuesday, 15 June 2010

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B3O3

B2O2

B1O1

Cite 3 Bottlenecks (negative, external or future)Cite 3 Opportunities: (positive, external or future)

W3S3

W2S2

W1S1

Cite 3 Weaknesses (negative, intrinsic)Cite 3 Strengths: (positive, internal factors)

4. What is your personal analysis of the field of systems biology for medical applications? Please, identify in a priority order the strengths, weaknesses, opportunities and bottlenecks for systems

medicine to become a reality in the future (short, medium, long term) in Europe.

STRENGTHS / WEAKNESSES / OPPORTUNITIES / BOTTLENECKS

3. Do you know of any national or international research programs in systems biology relevant to medicine?

2. Why do you think systems biology approaches can realistically contribute to medicine and clinical applications, in the short, medium and long term? Please, describe any examples of success stories of systems biology actually working in medicine.

1. "Systems medicine: the application of systems biology approaches to medical research". Do you think this is an adequate definition of systems medicine? How would you define systems medicine?

GENERAL QUESTIONS

Template questionnaire submitted to experts (1/2)

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11. What kind of research opportunities would attract industries/pharma into the systems biology and systems medicine fields?

10. What kind of research opportunities would attract SMEs into the systems biology and systems medicine fields?

9. Which areas of systems biology and systems medicine would benefit from international collaboration?

8. What other actions should be taken to develop the field of systems medicine? (Strategic workshops, consultation of the research/medical community, conferences, coordination actions, publications & press events etc.)

POLICY

7. What are the main strategic scientific areas in systems medicine and why do they need to be addressed through a European collaboration in the future (short, medium, long term)? Please, prioritize. Please, give examples of specific research topics that could be addressed in the next 2 years in the FP7 Health programme.

SYSTEMS MEDICINE: A EUROPEAN STRATEGY

6. What are the key improved or new tools and technologies required to make systems medicine a reality?

5. What are the required resources and infrastructures to make systems medicine a reality?

RESOURCES / TECHNOLOGIES

Template questionnaire submitted to experts (2/2)

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List of invited experts (1/2)

European Molecular Biology organisation (EMBO)Lemberger Thomas

Turku Centre for Biotechnology, FinlandLahesmaa Riitta

Systems Biology Ireland & Conway Institute, University College Dublin, Ireland

Kolch Walter

German Cancer Research Center (DKFZ), GermanyKlingmüller Ursula

CSO, Bio-modelling Systems, FranceIris Francois

Obsidian Biomedical Consulting, UKHenney Adriano

Laboratory of Medicine, University of Edinburgh, UKHarrison David

Diabetes and Endocrinology, Faculty of Medicine, Lund University, Sweden

Groop Leif

Computational Systems Biology, University of Edinburgh, UKGoryanin Igor

Medical Research Council, UKFoulkes Tom

Dept. of Respiratory Diseases - University of Modena and Reggio Emilia, Italy

Fabbri Leonardo M.

Dept. of Chemistry - University of Liège, BelgiumDe Pauw Edwin

Scientific Director, Novo Nordisk A/S, DenmarkColding- JØrgensenMorten

Dept. of Biochemistry and Molecular Biology - University of BarcelonaCascante Marta

Centre for Mathematical Medicine and Biology, University of Nottingham, UK

Byrne Helen

Center for Genomic Regulation (CRG), Barcelona, SpainBertero Michela

Unit for Clinical Systems Biology, Gothenburg University, SwedenBenson Mikael

Luxemburg Centre for Systems Biomedicine, University of LuxembourgBalling Rudi

Functional Genomics and Systems Biology for Health, CNRS and Pierre & Marie Curie University of Paris VI, France

Auffray Charles

AFFILIATIONNAME

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List of invited experts (2/2)

Dept. of Systems Biology & Bioinformatics - University of Rostock, Germany

Wolkenhauer Olaf

Hamilton Institute NUIM, IrelandWellstead Peter

Dept. of Neurology, University Medical Center Utrecht, The Netherlandsvan den Berg Leonard

Institute for Ophthalmic Research - Tuebingen University, GermanyUeffing Marius

AstraZeneca, UKSwinton Jonathan

Unit of Cardiovascular Genetics, Faculty of Pharmacy, University of Nancy, France

Siest Gerard

Functional Genomics and Bio-Chips, Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Slovenia

Rozman Damjana

Hospital Clinic, University of Barcelona, SpainRoca Josep

Emergentec biodevelopment GmbH, AustriaMayer Bernd

Immunology, Infection, Vaccinology, INSERM, FranceLotteau Vincent

Bundesministerium für Bildung und Forschung, Molekulare Lebenswissenschaften, BMBF, Germany

Lichtenberg Hella

Rythmes biologiques et cancers, INSERM, FranceLévi Francis

AFFILIATIONNAME

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EC Staff

Scientific OfficerGANCBERG David

Scientific OfficerSAUTTER Juergen

Scientific OfficerMARCUS Frederick

Scientific OfficerKESSLER Charles

Scientific OfficerHOLTEL Andreas

Scientific OfficerBUESING Juergen

FUNCTIONNAME

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FP6 funded projects in Systems Biology (1/4)

Dedicated Integration And Modelling Of Novel Data and prior knowledge to enable Systems biologyProject Coordinator: Prof. Martin Kuiper – Flanders Interuniversity Institute for BiotechnologyStarting date: Jan. 2005Duration: 42 monthsEC Funding: 2.500.000 €www.sbcellcycle.org

DIAMONDS

Computational Systems Biology of Cell SignallingProject Coordinator: Prof. Olaf Wolkenhauer – Universität RostockStarting date: Jan. 2005Duration: 39 monthsEC Funding: 1.684.159 €

COSBICS

An integrative approach to cellular signalling and control processes: Bringing computational biology to the benchProject Coordinator: Prof. Luis Serrano – Centre de Regulacio GenomicaStarting date: March 2004Duration: 36 monthsEC Funding: 1.998.000 €

COMBIO

Integrative Genomics and Chronic Disease Phenotypes: modelling and simulation tools for cliniciansProject Coordinator: Josep Roca – Institut d’Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS)Starting date: Dec. 2006Duration: 30 monthsEC Funding: 1.800.000 €

BIOBRIDGE

Towards an understanding of dynamic transcriptional regulation at global scale in bacteria: a systems biology approachProject Coordinator: Dr. Philippe NoirotStarting date: Nov. 2006Duration: 48 monthsEC Funding: 12.029.619 €

BASYSBIO

Systems biology of the AMP-activated protein kinase pathwayProject Coordinator: Prof. Stefan Hofmann – Gothenburg UniversityStarting date: Jan. 2006Duration: 42 monthsEC Funding: 2.106.593 €

AMPKIN

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European Lipidomics InitiativeProject Coordinator: Prof. Gerrit van MeerStarting date: Jan. 2005Duration: 30 monthsEC Funding: 487.200 €www.lipidomics.net

ELIFE

Workshop on "Systems biology of DNA-damage-induced stress responses“Project Coordinator: Dr. Harry Vrieling – Leiden University Medical CenterStarting date: Sept. 2004Duration: 18 monthsEC Funding: 60.000 €

EU-USWORKSHOP

The Take-off of European Systems BiologyProject Coordinator: Dr. Petra Wolff - Forschungzentrum Juelich GmbHStarting date: Nov. 2003Duration: 24 monthsEC Funding 500.000 €www.eusysbio.org

EUSYSBIO

A strategic forum for the dialogue and coordination of European life sciences funders and performersProject Coordinator: Prof. Marja Makarow – European Science FoundationStarting date: Jan. 2006Duration: 36 monthsEC Funding: 907.790 €

EUROBIOFUND

European Systems Biology Initiative for combating Complex DiseasesProject Coordinator: Prof. Dr. Hans LehrachStarting date: Nov. 2005Duration: 24 monthsEC Funding: 350.000 €

ESBIC-D

ENFIN - an Experimental Network for Functional IntegrationProject Coordinator: Prof. Gianni Cesareni - University of Rome Tor VergataStarting date: Nov. 2005Duration: 60 monthsEC Funding: 8.967.500 €

ENFIN

European modelling initiative combating complex diseasesProject Coordinator: Dr. Half Herwig – Max Planck Institute for Molecular GeneticsStarting date: Jan. 2004Duration: 42 monthsEC Funding: 1.905.772 €http://pybios.molgen.mpg.de/EMICD

EMI-CD

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The Temporal Dimension in Functional GenomicsProject Coordinator: Prof Marina Bentivoglio – University of VeronaStarting date: Jan. 2007Duration: 24 monthsEC Funding: 250.000 €

PROUST

Towards European Neuromal Cell Simulation: a European consortium to integrate the scientific activities for the creation of a European Alliance devoted to the complete in-silico model of Neuronal CellProject Coordinator: Dr. Ivan Arisi – Lay line Genomics SpA.Starting date: Nov. 2003Duration: 24 monthsEC Funding: 200.000 €www.symbionicproject.org

SYMBIONIC

Systems biology strategies and metabolome engineering for the enhanced production of recombinant proteins in StreptomycesProject Coordinator: Prof. Jozef Anné – Catholic University of LeuvenStarting date: Jan 2007Duration: 36 monthsEC Funding: 2.850.851 €www.streptomics.org

STREPTOMICS

Systems Biology of RNA Metabolism in YeastProject Coordinator: Prof. Jean Beggs – University of EdinburghStarting date: Jan. 2006Duration: 48 monthsEC Funding: 2.400.000 €

RIBOSYS

Quantifying signal transductionProject Coordinator: Prof Stefan Hohmann – Gothenburg UniversityStarting date: Jan 2004Duration: 42 monthsEC Funding:1.920.410 €www.idp.mdh.se/quasi

QUASI

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Systems Biology for Medical ApplicationsProject Coordinator: Dr. Karsten SchürrleStarting date: Dec. 2006Duration: 25 monthsEC Funding: 362.500 €

SYSBIOMED

Systematic functional analysis of intracellular parasitism as a model of genomes conflictProject Coordinator: Dr. Alexander Kel – BIOBASE GmbHStarting date: Sept. 2007Duration: 36 monthsEC Funding: 1.840.719 €

SYSCO

Yeast Systems Biology NetworkProject Coordinator: Prof. Jens NielsenStarting date: Nov. 2005Duration: 36 monthsEC Funding: 1.300.000 €www.ysbn.eu

YSBN

Validated Predictive Dynamic Models of Complex Intracellular Pathways Related to Cell Death and SurvivalProject Coordinator: Dr. Antoine Depaulis – Institut des Neurosicences, Centre de Recherche INSERM U 836Starting date: Oct. 2006Duration: 36 monthsEC Funding: 1.488.560 €www.valapodyn.eu

VALAPODYN

Temporal Genomics for Tailored ChronotherapeuticsProject Coordinator: Dr. Francis Lévi - INSERMStarting date: Oct. 2006Duration: 36 monthsEC Funding: 2.086.720 €

TEMPO

System-wide analysis and modelling of protein modificationProject Coordinator: Dr. Arif Malik – MicroDiscovery GmbHStarting date: Jan. 2007Duration: 36 monthsEC Funding: 2.097.268 €www.sysprot.eu

SYSPROT

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Cis-regulatory logic of the transcriptional control in neural stem cellsProject Coordinator: Dr Jean-Stéphane Joly - INSTITUT NATIONALE DE LA RECHERCHE AGRONOMIQUEStarting date: Nov. 2008Duration: 36 monthsEC Funding: 2.984.169 €http://www.cisstem.eu/

CISSTEM

Mathematical modelling of beta-catenin and ras signalling in liver and its impact on proliferation, tissue organization and formation of hepatocellular carcinomasProject Coordinator: Prof. Jan G. Hengstler - FORSCHUNGSGESELLSCHAFT FUR ARBEITSPHYSIOLOGIE UND ARBEITSSCHUTZ EVStarting date: Nov. 2008Duration: 36 monthsEC Funding: 2.992.024 €http://www.ifado.de/cancersys/

CANCERSYS

A systems BIOlogy Study to TAilored Treatment in Chronic Heart FailureProject Coordinator: Prof. D.J. van Veldhuisen - ACADEMISCH ZIEKENHUIS GRONINGENStarting date: April 2010Duration: 60 monthsEC Funding: 11.894.287 €

BIOSTAT-CHF

Analysing and Striking the Sensitivities of Embryonal TumoursProject Coordinator: UNIVERSITY COLLEGE DUBLINStarting date: UNDER NEGOTIATIONDuration: 60 monthsEC Funding: 11.999.157 €

ASSET

Apoptosis systems biology applied to cancer and AIDS. An integrated approach of experimental biology, data mining, mathematical modelling, biostatistics, systems engineering and molecular medicineProject Coordinator: Prof. Boris Zhivotovsky - KAROLINSKA INSTITUTETStarting date: Feb. 2008Duration: 48 monthsEC Funding: 11.000.000 €http://www.apo-sys.eu/

APO-SYS

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Molecular Networks of Dopaminergic Neurons in ChordatesProject Coordinator: Prof. Stefano Gustincich - SCUOLA INTERNAZIONALE SUPERIORE DI STUDI AVANZATIStarting date: Feb. 2009Duration: 36 monthsEC Funding: 2.967.180 €http://www.dopaminet.eu/index.php

DOPAMINET

European multidisciplinary ALS network identification to cure motor neuron degenerationProject Coordinator: UNIVERSITAIR MEDISCH CENTRUM UTRECHTStarting date: UNDER NEGOTIATIONDuration: 60 monthsEC Funding: 8.998.359 €

EURO-MOTOR

Epigenetics towards systems biologyProject Coordinator: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEStarting date: UNDER NEGOTIATIONDuration: 60 monthsEC Funding: 11.995.027 €

EPIGENESYS

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A system view on the differential activities of human type I interferonsProject Coordinator: Prof. Jacob Piehler - UNIVERSITAET OSNABRUECKStarting date: Jan. 2009Duration: 48 monthsEC Funding: 2.866.405 €

IFNACTION

Genetic and Epigenetic Networks in Cognitive DysfunctionProject Coordinator: KATHOLIEKE UNIVERSITEITStarting date: UNDER NEGOTIATIONDuration: -EC Funding: 11.647.068 €

GENCODYS

Tackling the future challenges in Systems BiologyProject Coordinator: GOETEBORGS UNIVERSITETStarting date: Aug. 2008Duration: 36 monthsEC Funding: 500.000 €http://sysbio.se/FutureSysBio/

FUTURESYSBIO

Towards the establishment of a permanent European Virtual Institute dedicated to Malaria Research (EVIMalaR).Project Coordinator: Prof. Andrew Waters - UNIVERSITY OF GLASGOWStarting date: Oct. 2009Duration: 60 monthsEC Funding: 12.000.000 €http://www.evimalar.org/

EVIMALAR

European Consortium for Systematic Stem Cell BiologyProject Coordinator: Prof. Austin Smith - UNIVERSITY OF CAMBRIDGEStarting date: March 2008Duration: 48 monthsEC Funding: 12.000.000 €http://www.eurosystemproject.eu/

EUROSYSTEM

European Consortium on Synaptic Protein Networks in Neurological and Psychiatric DiseasesProject Coordinator: Prof. Nils Brose - MAX PLANCKStarting date: Jan. 2010Duration: 48 monthsEC Funding: 11.952.691 €http://www.eurospin.mpg.de/

EUROSPIN

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Systems Biology of MitosisProject Coordinator: FORSCHUNGSINSTITUT FUER MOLEKULARE PATHOLOGIE GES.M.B.HStarting date: UNDER NEGOTIATIONDuration: 60 monthsEC Funding: 10.198.241 €

MITOSYS

Integration of the system models of insulin signalling and of mitochondrial function and its application in the study of complex diseasesProject Coordinator: Prof. Antonio Zorzano - FUNDACIO PRIVADA INSTITUT DE RECERCA BIOMEDICA IRBStarting date: Nov. 2008Duration: 36 monthsEC Funding: 2.956.490 €http://mitin-fp7.eu/

MITIN

Characterization and quantitative modeling of DNA mismatch repair and its role in the maintenance of genomic stability and cancer avoidanceProject Coordinator: Dr. Ir. Joyce Lebbink - ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAMStarting date: Nov. 2008Duration: 48 monthsEC Funding: 3.000.000 €http://www.mm2m.eu/

MISMATCH2MODEL

Molecular coding and subset specification of dopamine neurons generating the the meso-limbic and nigro-striatal systemProject Coordinator: Prof. Marten P. Smidt - UNIVERSITAIR MEDISCH CENTRUM UTRECHTStarting date: Jan. 2009Duration: 36 monthsEC Funding: 2.582.749 €http://www.mddaneurodev.eu/

MDDANEURODEV

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Quantitative pathway analysis of natural variation in complex disease signalingin C. elegansProject Coordinator: Dr. Jan Kammenga - WAGENINGEN UNIVERSITEITStarting date: Jan. 2009Duration: 48 monthsEC Funding: 2.801.230 €http://www.panaceaproject.eu/UK/

PANACEA

Predicting long-term toxic effects using computer models based on systems characterization of organotypic culturesProject Coordinator: UNIVERSITAET DES SAARLANDESStarting date: UNDER NEGOTIATIONDuration: -EC Funding: 4.999.981 €

NOTOX

Genomic Regulatory Systems of Human X-linked neurological diseasesProject Coordinator: Prof. Thomas Becker - UNIVERSITETET I BERGENStarting date: June 2009Duration: 36 monthsEC Funding: 2.997.197 €

NEUROXSYS

Multi-layer network modules to identify markers for personalized medication in complex diseasesProject Coordinator: GOETEBORGS UNIVERSITETStarting date: Nov. 2008Duration: 48 monthsEC Funding: 2.525.888 €http://www.multimod-project.eu/

MULTIMOD

Systems biology of liver cancer: an integrative genomic-epigenomic approachProject Coordinator: ISTITUTO EUROPEO DI ONCOLOGIA SRLStarting date: UNDER NEGOTIATIONDuration: 60 monthsEC Funding: 11.936.899 €

MODHEP

Genomic determinants of inflammation: from physical measurements to system perturbation and mathematical modellingProject Coordinator: Dr Irina Udalova - IMPERIAL COLLEGEStarting date: Dec. 2008Duration: 42 monthsEC Funding: 2.926.305 €http://www.model-in.org/

MODEL-IN

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Systems Biology of T-cell Activation in Health and DiseaseProject Coordinator: Dr. Wolfgang SCHAMEL and Prof. Michael RETH - MAX PLANCKStarting date: April 2008Duration: 60 monthsEC Funding: 11.100.000 €http://www.sybilla-t-cell.de/simple_layout/content.htm

SYBILLA

Finding biomarkers of anti-microbial drug resistance via a systems biology analysis of fungal pathogen interactions with the human immune systemProject Coordinator: EUROPEAN MOLECULAR BIOLOGYStarting date: Nov. 2009Duration: 36 monthsEC Funding: 4.291.161 €http://www.sybaris-fp7.eu/

SYBARIS

Systems biology approaches to understand cell pluripotencyProject Coordinator: BIOTALENTUM TUDASFEJLESZTO KFTStarting date: Jan. 2009Duration: 36 monthsEC Funding: 2.965.438 €http://plurisys.biotalentum.eu/

PLURISYS

A systems approach linking genotype and environment to phenotype: oxidative stress response mechanisms in fission yeastProject Coordinator: Prof. Andreas Beyer - TECHNISCHE UNIVERSITAET DRESDENStarting date: Oct. 2008Duration: 36 monthsEC Funding: 2.475.460 €http://www.phenoxigen.eu/

PHENOXIGEN

Systems biology of phagosome formation and maturation, modulation by intracellular pathogensProject Coordinator: Dr. Brian Robertson - IMPERIAL COLLEGEStarting date: Nov. 2008Duration: 36 monthsEC Funding: 2.990.375 €http://www3.imperial.ac.uk/cisbic/research/phagosys

PHAGOSYS

New Algorithms for Host Pathogen Systems BiologyProject Coordinator: UNIVERSITAET HEIDELBERGStarting date: 48 monthsDuration: UNDER NEGOTIATIONEC Funding: 2.968.825 €

PATHOSYS

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Systems biology of Mycobacterium tuberculosisProject Coordinator: FUNDACIO PRIVADA CENTRE DE REGULACIO GENOMICAStarting date: April 2010Duration: 54 monthsEC Funding: 10.562.601 €

SYSTEMTB

Systems microscopy – a key enabling methodology for next-generation systems biologyProject Coordinator: KAROLINSKA INSTITUTETStarting date: UNDER NEGOTIATIONDuration: 60 monthsEC Funding: 11.986.690 €

SYSTEMS MICROSCOPY

Systems biology towards novel chronic kidney disease diagnosis and treatmentProject Coordinator: Prof. Bernd Mayer - EMERGENTEC BIODEVELOPMENT GMBHStarting date: Jan. 2010Duration: 60 monthsEC Funding: 11.789.534 €

SYSKID

Systems Biology of Colorectal CancerProject Coordinator: KAROLINSKA INSTITUTETStarting date: UNDER NEGOTIATIONDuration: 60 monthsEC Funding: 11.999.996 €

SYSCOL

A systems biology approach to dissect cilia function and its disruption in human genetic diseaseProject Coordinator: Dr. Marius Ueffing - STICHTING KATHOLIEKE UNIVERSITEITStarting date: June 2010Duration: 60 monthsEC Funding: 11.069.083 €

SYSCILIA

Synaptic Systems: dissecting brain function in health and diseaseProject Coordinator: VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS WETENSCHAPPELIJK ONDERZOEK EN PATIENTENZORGStarting date: UNDER NEGOTIATIONDuration: 48 monthsEC Funding: 10.739.837 €

SYNSYS

Systems Biology of Stem Cells and ReprogrammingProject Coordinator: Prof. A. Francis Stewart - UNIVERSITAET DRESDENStarting date: June 2010Duration: 60 monthsEC Funding: 10.530.000 €

SYBOSS

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Eukaryotic unicellular organism biology – systems biology of the control of cell growth and proliferationProject Coordinator: GOETEBORGS UNIVERSITETStarting date: April 2008Duration: 60 monthsEC Funding: 11.700.000 €http://www.unicellsys.eu/

UNICELLSYS

Systems-Level, Multi-layer Understanding of Cellular Responses to Ionizing RadiationProject Coordinator: TEL AVIV UNIVERSITYStarting date: Jan. 2009Duration: 36 monthsEC Funding: 2.928.426 €

TRIREME

organising team - european...

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