October 15, 1991

CbnœrResearchOFFICIAL JOURNAL OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH

VOLUME 51 •¿�NO. 20 •¿�PP 5449-5780ISSN 0008-5472 •¿�CNREA 8

ASSISTANT OR ASSOCIATE PROFESSORAUTOLOGOUS BONE MARROW

TRANSPLANT ATION/BIOTH ERAPY

Childrcns Hospital Los Angeles (CHLA) and theUniversity of Southern California (USC) School ofMedicine, Department of Pediatrics are seeking aBC/BE Pediatrie Hematologist-Oncologist to beAssistant Clinical Director, Autologous BoneMarrowTransplantationProgram(SolidTumors).The candidate must have a minimum of 3 yearstraining/experience in bone marrow transplantationand should have the ability to perform clinical orlaboratory research in autologous transplantationand/or biotherapy (e.g., differentiation inducers,cytokines, monoclonal antibodies, hematopoiesis).This individual's effort will be 45% patient care and

teaching (ABMT and Hematology-Oncology), 45%research, 10%administration. Send curriculum vitaeand list of three references to Dr. Robert C. Seeger,Division of Hematology-Oncology, Children«Hospital Los Angeles, 4650 Sunset Boulevard,Los Angeles, CA 90027. CHLAandUSC areequalopportunity/affirmative action employers. Womenand minorities are encouraged to apply.

AntibodiesFor CancerResearch

Antibody reagents for the identificationof proteins in the study of cancer.

•¿�c-er6B-2 Oncogene Antibodies

•¿�HPV-16 E7 Monoclonal Antibody

•¿�Retinoblastoma (RB) Gene ProductMonoclonal Antibody

•¿�TAG-72 Monoclonal Antibody (B72.3)

1401 Harbour Bay Parkway, Alameda, CA 945011-800-874-8667 •¿�1-800-682-6200 (CAonly)TEL: 1-510-769-5202 •¿�FAX: 1-510-769-5252

FOR RESEARCH USE ONLY. Not for use in diagnostic procedures.

Cancer Research Dr. A. SmithIn Vivo and in vitro Analysis of..."

Filename: Smith.docHardware, Operating system, Software

CanoerResearchon disk to facilitate production.

accepts submissions

Acceptable word processing packages are listed in Guidelines forSubmitting Disks to AACR Publications, found in the back of every issueof Cancer Research. Tables and illustrations will be set from hard copy.

To submit your paper on disk, simply send a completed Disk SubmissionForm (found on the reverse of the Guidelines for Submitting Disks toAACR Publications) with your disk, labeled as shown above, to theAACR Publications Department. Be sure that the disk file is the mostrecent version of your paper and matches the hard copy printout.

For review purposes, 4 hard copy printouts of the manuscript and 4 copies of the originalillustrations must accompany all submissions.

MOLECULARONCOLOGYAS A BASISFORNEWSTRATEGIESIN CANCERTHERAPY

SecondJointConferenceoftheAmericanAssociationforCancerResearch

andtheJapaneseCancerAssociation

SheratonWaikikiHotel,Honolulu,HIFebruary10-14,1992

AACRI. BERNARDWEINSTEIN/ NewYork

Co-Chairperson

BRUCEA. CHABNER/ BethesdaYUNG-CHICHENG/ New Haven

HAROLDL. MOSES/ NashvilleANNAMARIESKALKA/ Philadelphia

SCIENTIFIC PROGRAM COMMITTEE

JCASUSUMUNISHIMURA/ Tokyo

Co-Chairperson

YOSHIYUKIHASHIMOTO/ TohokuTADAO KAKIZOE/ TokyoHIROSHIKOBAYASHI/ SapporoTOSHiKAZUNAKAMURA/ KyushuTAKAOSEKIYA/ Tokyo

SCIENTIFIC PROGRAM

MASANORISHIMOYAMA/ TokyoHARUOSUGANO/ TokyoTAKASHI SUGIMURA/ TokyoSHOZOTAKAYAMA/ TokyoMASAAKITERADA/ TokyoKUMAOTOYOSHIMA/ OsakaTAKASHITSURUO/ Tokyo

KeynoteAddressesTAKASHISUGIMURA/ TokyoBRUCEA. CHABNER/ Bethesda

OncogenesandTumorSuppressorGenesANNAMARIESKALKA/ PhiladelphiaKUMAOTOYOSHIMA/ OsakaCURTISC. HARRIS/ BethesdaHIROTOOKAYAMA/ OsakaEDWARDHARLOW/ CharlestownTADASHIYAMAMOTO/ TokyoSUSUMUNISHIMURA/ TokyoJACKSONB. GIBBS/ WestPointYUSUKENAKAMURA/ Tokyo

GrowthFactors,Cytokines,andReceptorsYOJIIKAWA / TsukubaHAROLDL. MOSES/ NashvilleMASAAKITERADA/ TokyoSTUARTA. AARONSON/ BethesdaTOSHIOHIRANO/ OsakaJOSEPHSCHLESSINGER/ NewYorkTOSHIZAKUNAKAMURA/ Fukuoka

TheCellSurface,SignalTransduction,andChemoprevention

ELLENS. VITETTA/ DallasTOSHIOKUROKI/ TokyoI. BERNARDWEINSTEIN/ NewYorkKATSUHIKOMIKOSHIBA/ OsakaMINAKONAGAO/ TokyoSHOICHIROTSUKITA / OkasakiWAUN Kl HONG/ Houston

AmericanAssociationfor CancerResearchPublic Ledger Building620 Chestnut Street, Suite 816Philadelphia, PA 19106-3483 USATelephone: (215)440-9300FAX: (215) 440-9313

RecentAdvancesinChemotherapyandDrugResistance

ENRICOMIHICH/ BuffaloMESANORISHIMOYAMA/ TokyoKURTW. KOHN/ BethesdaJUDAHM. FOLKMAN/ BostonMICHAELM. GOTTESMAN/ BethesdaTAKASHITSURUO/ TokyoSUSANBANDHORWITZ/ NewYorkHIROSHIMAEDA/ Kumamoto

MolecularTargetingApproachesV. CRAIGJORDAN/ MadisonYOSHIUKIHASHIMOTO/ TohokuTERUHIKOBEPPU/ TokyoSHIN YONEHARA/ TokyoPAULS. MILLER/ BaltimoreJOSEPHR. BERTINO/ NewYorkTOSHIOTAKAHASHI/ Kyoto

MolecularGenetics,Models,andStrategiesMICHAELBLAESE/ BethesdaFUMIMARUTAKAKU/ TokyoYOSHIHIDEHAYASHIZAKI/ OsakaKUNITADASHIMOTOHNO/ TokyoTAKAOSEKIYA/ TokyoMOTOYAKATSUKI/ IseharaARGIRISEFSTRATIADIS/ NewYork

OverviewandSummaryYUNG-CHI CHENG / New Haven

Scientistsareencouragedto submitabstractsof papersforconsiderationforpostersessions.Personsin theAmericasandcountriesotherthanJapanmayobtainadditionalinformationfromtheAACROffice.

JapaneseCancerAssociationNational Cancer Center5-1-1 Tsukiji, Chuo-kuTokyo, 104 JAPAN

The Division ofCancer Etiology

National Cancer InstituteAnnounces To the Scientific Community The Availability of the FollowingResources/Services For Cancer Related Research As Noted Below:

Biological Resources

•¿�Cell Culture Identification Service. UsingIsozyme Analysis, Immunofluorescence andKaryotypic Analysis (Chromosome Banding).Contact: Dr. Ward PetersonChildren's Hospital of Michigan

3901 Beaubien BoulevardDetroit, Ml 48201(313) 745-5570

Citing Contract #N01-CP-85645

Cost: $375/Analysis

•¿�Goat Antisera Against: Avian, Bovine,Feline, Murine, and Primate Intact Virusesand Viral Proteins; Antibodies to Immuno-globulins for a number of species. Preimmune Sera available for some Virus Antisera.Contact: Alice K. Robison,Ph.D.

BCB RepositoryQuality Biotech, Inc.1667 Davis StreetCamden, NJ 08104(609) 966-8000(609) 342-8078 FAX

Citing Contract #N01-CP-15665

Cost: $75.00/5 ml. (Antisera)25.00/5 ml. (Preimmune Sera)65.00/100 ml. (Immunoglobulins)(Frozen Material)

•¿�Viruses: Avian, Feline, Murine, and PrimateViruses Produced in vivo and in vitro.Contact: Alice K. Robison,Ph.D.

BCB RepositoryQuality Biotech, Inc.1667 Davis StreetCamden, NJ 08104(609) 966-8000(609) 342-8078 FAX

Cost:

Citing Contract #N01-CP-15665

Inquire

•¿�Monoclonal Antibodies are available withspecificities for synthetic peptides representing the amino acid sequences of the leftend, right end and active site of the oncogene products of avian and mammalianretroviruses. Blocking peptides are also available, as are a limited number of cell linesproducing the monoclonal antibodies.

Contact: Alice K. Robison,Ph.D.BCB RepositoryQuality Biotech, Inc.1667 Davis StreetCamden, NJ 08104(609) 966-8000(609) 342-8078 FAX

Citing Contract #N01-CP-15665Cost: Peptides -$25.00/mg.

Ascites Fluid - 45.00/ml.Cell Culture -100.00/culture.

(Plus Shipping and Handling)

•¿�Human sera from donors with: Malignancies (including nasopharyngeal carcinoma),Non-Malignant Disorders, and NormalIndividuals

Contact: Coordinatorfor ResearchResources

Biological Carcinogenesis Branch,DCE, NCI. NIH

Executive Plaza North, Room 540Bethesda, MD 20892

Cost: Shippingand handlingchargesonly.

•¿�The Division of Cancer Etiology's Registry

of Experimental Cancers announces theavailability of 16 different study setscontaining histologie slides of rodent tumors.The study sets, with accompanying syllabi,illustrate a variety of spontaneous andinduced tumors, chiefly of rats, mice, andmastomys. Each set is available to cancerinvestigators worldwide, without charge, forup to two months. Requests or inquiriesshould be addressed to:Contact: Registryof ExperimentalCancers

National Cancer InstituteBuilding 41, Room D311NIH, Bethesda, MD 20892USA

Chemical Resources

•¿�Analytical resources for the collection,separation, and elucidation of the components of cigarette smoke and cigarettesmoke condensâtes:A contractor with experience in the development of analyticalmethods for the determination of constituentsof cigarette smoke and of specialty instrumentation for inhalation toxicology is availableto assist qualified investigators with particularinterest in studies on human and animalmodel exposure to environmental and side-stream smoke. A large inventory of referenceexperimental cigarettes, Standard Low YieldReference Cigarettes, and an extensivechemical data base on smoke and smokecondensate components is available.Contact: Harold E. Seifried,Ph.D.

Chemical and PhysicalCarcinogenesis Branch DCE, NCI

Executive Plaza North, Room 700Bethesda, MD 20892(301)496-5471

Cost: Inquire

•¿�Chemical Carcinogen Reference StandardRepository: Reference quantities of over 750compounds are available. The newest additions are dilute aqueous standards of PAHdeoxyguanosine-3'-monophosphates forRanderath 32Ppost labelling assays. Otherclasses of available compounds are: feca-pentaenes, food mutagens, polynucleararomatic hydrocarbons (PAH), PAH metabolites, radiolabeled PAH metabolites, nitrogenheterocycles, nitrosamines/nitrosamides.aromatic amines, aromatic amine metabolites, azo/azoxy aromatics. inorganics, nitroar-omatics, pesticides, Pharmaceuticals, naturalproducts, dyes, dioxins and chlorinatedaliphatics. Data sheets provided with thecompounds include chemical and physicalproperties, analytical data, hazards, storage,and handling information. Catalog availableupon request.

Contact: Manager, NCI ChemicalCarcinogen Repository

Midwest Research Institute425 Volker BoulevardKansas City, MO 64110(816)753-7600, Ext. 523

Cost: Subjectto chemicalclass code andquantity (see catalog) plus handlingand shipping charges.

Epidemiology Resources

•¿�The Tumor Virus Epidemiology Repository(TVER)contains sera and other biologicalsamples from more than 13,000 patients andcontrols obtained in 12 different countries.The TVER was established primarily tosupport collaborative research on the roleof Epstein-Barr virus (EBV) in Burkitt's

lymphoma, nasopharyngeal carcinoma, andrelated diseases.The TVER is able to adjust its collection tofacilitate the development of new collaborative studies. In addition, some samples areavailable for reagents and independentresearch. The most extensive collections areserum samples from patients with Burkitt's

lymphoma (sera from more than 1,000patients).

Contact: Dr. Paul H. LevineEnvironmental Epidemiology

Branch, DCE, NCI, NIHExecutive Plaza North, Room 434Bethesda, MD 20892(301)496-8115

Cost: Free to CollaboratingInvestigators;Others: Dependent on Processing

Time

•¿�The National Cancer Institute has availablethe Animal Morbidity/Mortality Survey ofColleges of Veterinary Medicine in NorthAmerica (also known as the VeterinaryMedical Data Program). This unique registryof veterinary medical information representspatient data on animals seen at collaboratingveterinary teaching facilities; 3 million hospitalepisodes have been abstracted and computerized in a standardized record format.Disease information is coded using thescheme of the Standard Nomenclature ofVeterinary Disease and Operations. Thecomputer tapes will be made available uponrequest.Contact: Dr. Howard M. Hayes

Environmental Epidemiology BranchEpidemiology and Biostatistics

ProgramDivision of Cancer EtiologyExecutive Plaza North, Room 443Bethesda, MD 20892(301)496-1691

Cost: Inquire

•¿�The National Institute of Allergy and Infectious Diseases and the National CancerInstitute have developed a repository ofbiological specimens from homosexual men.The specimens were collected throughcontracts with five major U.S. universities forstudies of the natural history of acquiredimmune deficiency syndrome (AIDS).Information about applying for collaborativeuse of these specimens is available from theNIAID Project Officer or the NCI Co-ProjectOfficer.Contact: Chief, EpidemiologyBranch,AIDS

ProgramNational Institute of Allergy and

Infectious DiseasesCDC Bldg., Room 240National Institutes of HealthBethesda, MD 20892

or to ChiefExtramural Programs Branch, EBP,Division of Cancer Etiology, NCIExecutive Plaza North, Room 535Bethesda, MD 20892

•¿�Human fibroblast cultures from individualsat high risk of cancer, members of cancer-prone families, and normal family membersare available. Collection is historical withunknown viability. Catalog unavailable.Information requests should include potentialuse of cultures.Contact: Chief, FamilyStudiesSection,EEB,

DCE, NCI, NIHExecutive Plaza North, Room 439Bethesda, MD 20892(301) 496-4375

Cost: Free to collaboratinginvestigatorsOthers: $70/cell line.

•¿�The Epidemiology and BiostatisticsProgram of the National Cancer Institute hasdeveloped the Observed versus Expected(0/E) software system which calculates: (1)the number of observed events (e.g. cancercases or deaths) in a study group at risk; (2)the number of expected events in a studygroup based on the rate of occurrence insome standard or referent population; (3) theratio of observed to expected events; and (4)the significance of this ratio. The system isuser friendly and capable of executing aseries of calculations by different variablessuch as age, time group, date of exposure,age at date of exposure, duration of exposure, year relative to entry and cause ofevent. The 0/E System provides tables byrace, sex and user defined variables, allowsuser defined latency intervals and acceptsstandard or user prepared rates. 0/E iswritten in COBOL and is exportable to mostmainframes.

Contact: Ruth WolfsonEpidemiology and Biostatistics

ProgramDivision of Cancer Etiology, NCIExecutive Plaza North, Room 531Bethesda, MD 20892(301)496-1606

Cost: Free to investigatorsinterestedinepidemiologie research.

Environmental Cancer

•¿�NCI's Chemical Carcinogenesis Research

Information System (CCRIS) is availableonline through the National Library of Medicine's Toxicology Data Network (TOXNET)

system. Through an interagency agreementbetween NCI and NLM, the CCRIS databasehas been built and will be maintained andupdated as one of TOXNET's sponsored

databases in the broad areas of chemistry,toxicology, and hazardous waste information.The CCRIS database contains evaluated dataand information on carcinogens, mutagens,tumor promoters, cocarcinogens, metabolitesof carcinogens, and carcinogen inhibitorsderived from published review articles,ongoing current awareness survey of primaryliterature, NCI/NTP's short- and long-term

bioassay studies, the IARC Monographs onthe Evaluation of Carcinogenic Risk of Chemicals to Man, and special studies andreports.

Contact: Dr. ThomasP. CameronOffice of the DirectorDivision of Cancer EtiologyNational Cancer InstituteExecutive Plaza North, Room 712Bethesda, MD 20892(301)496-1625

Cost: Inquire

•¿�The Special Assistant for EnvironmentalCancer, Office of the Director, announces theavailability of a limited number of copies ofthe following publications, which have beenprepared under contract to NCI:

Survey of Compounds Which Have BeenTested for Carcinogenic Activity, PHS-149,1987-1988

And Proceedings of the Fourth NCI/EPA/NIOSH Collaborative Workshop: Progress onJoint Environmental and OccupationalCancer Studies, 1986

Contact: Ms. I.C. BlackwoodOffice of the DirectorDivision of Cancer EtiologyNational Cancer InstituteExecutive Plaza North, Room 712Bethesda, MD 20892(301)496-1625

Cost: Free to investigatorsinterestedinenvironmental cancer.

ConceptsandMolecularMechanismsof MultistageCarcinogenesisFirstJointConferenceof theAmericanAssociationforCancerResearch

andtheEuropeanAssociationforCancerResearchimmediatelyfollowingEACR-XIin Genoa

AdditionalSupportfromtheIstitutoNazionaleperlaRicercasulCancro

GrandHotelMiramare,SantaMargherita,ItalyNovember6-9,1991

SCIENTIFIC PROGRAM COMMITTEE

AACRI. BERNARDWEINSTEIN/ NewYork,USA(Co-Chairperson)

ARTHURP. GROLLMAN/ StonyBrook.USAHAROLDL. MOSES/ Nashville,USA

EACRPETERBANNASCH/ Heidelberg.Germany(Co-Chairperson)

ALLANBALMAIN/ Glasgow.ScotlandJAN SVOBODA/ Prague.Czechoslovakia

LOCAL ORGANIZING COMMITTEELEONARDOSANTI/ Genoa,Italy(Chairperson)

MARIA COLNAGHI / Milan, Italy CLAUDIO LOMBARDO / Genoa. Italy

MARGARETFOTI/ Philadelphia.USA MARCELROBERFROID/ Brussels,Belgium

WelcomingRemarksLEONARDO SANTI / Genoa, Italy

OpeningAddressPETERBANNASCH/ Heidelberg,Germany

Epidemiological and ExperimentalEvidence for the Multistage Process

HENRYC.PITOT/ Madison,USAERICHHECKER/ Heidelberg,GermanyFRANCOMERLETTI/ Turin,ItalyFRIEDRICHMARKS/ Heidelberg.GermanyFRANCISV.CHISARI/ LaJolla.USA

APPLICATIONFORMS(Northand SouthAmerica)AmericanAssociationforCancerResearchPublicLedgerBuilding620ChestnutStreet,Suite816Philadelphia,PA19106,USA215-440-9300 215-440-9313(FAX)

(Outsidethe Americas)ItalianaCongressiViaBensa216124Genoa,ITALY10-202541 10-299382 (FAX)

SCIENTIFIC PROGRAM

DNAReplication,Damage,andRepair

MARCEL ROBERFROID / Brussels, Belgium

DEZIDER GRUNBERGER / New York. USA

HARTMUT M. RABES / Munich, Germany

ARTHUR P. GROLLMAN / Stony Brook. USA

PHILIP C. HANAWALT / Stanford. USA

TOMAS LINDAHL / Herts. England

SARASWATI SUKUMAR / San Diego, USA

MultipleGeneticChangesduringTumorDevelopment

LANCEA. LIOTTA/ Bethesda,USAJAN SVOBODA/ Prague.CzechoslovakiaALLANBALMAIN/ Glasgow.ScotlandANTONBERNS/ Amsterdam,The NetherlandsTERRYH. RABBITTS/ Cambridge,EnglandWEBSTERK. CAVENEE/ Montreal.Canada

GeneticAspectsofTumorSuppression

GEORGEKLEIN/ Stockholm.SwedenERICJ. STANBRIDGE/ Irvine.USAMARYWEISS/ Paris.FranceDAVIDP. LANE/ Herts,EnglandNICHOLASHASTIE/ Edinburgh.ScotlandEDWARDHARLOW/ Charlestown,USA

GrowthFactorsandSignalTransduction

HAROLD L. MOSES / Nashville. USA

GIUSEPPE DELLA PORTA / Milan. Italy

CHRISTOPHER J. MARSHALL / London,EnglandCARL-HENRIK HELDIN / Uppsala, Sweden

RIK DERYNCK / South San Francisco, USA

OverviewandFutureDirectionsI. BERNARD WEINSTEIN / New York, USA

TheAACRandEACRinvitetheinternationalcommunityofcancerresearcherstosubmitapplicationsforthisexcitingconference.

A limitednumberof travelgrantsforgraduateandmedicalstudents,postdoctoralfellows,andphysiciansin trainingwillbeavailable.

The American Association for Cancer Research

announces

AACR Special Conferences in Cancer Research

NEGATIVECONTROLS ON CELL GROWTH AND THEIRBREAKDOWNDURINGTHE PATHOGENESIS OF CANCER

October 20-24, 1991, Chatham, MassachusettsOrganizers: Robert A. Weinberg, Arnold J. Levine,

David M. Livingston, Eric J. Stanbridge

CONCEPTS AND MOLECULAR MECHANISMS OF MULTISTAGE CARCINOGENESIS

November 6-9,1991, Santa Margherita, ItalyOrganizers: I. Bernard Weinstein, Peter Bannasch,

Arthur P. Grollman, Harold L. Moses, Allan Balmain, Jan Svoboda

CELLULAR RESPONSES TO ENVIRONMENTAL DNA DAMAGE

December 1-6,1991, Banff, Alberta, CanadaOrganizers: Philip C. Hanawalt, Malcolm C. Paterson

AMERICAN ASSOCIATION FOR CANCER RESEARCHPublic Ledger Building

620 Chestnut Street, Suite 816Philadelphia, PA 19106

215-440-9300 215-440-9313 (FAX)

COVER LEGEND

,^ a», il. m

, CanœrResearch

Steven T. Rosen, M.D., pictured on this issue's

cover, is the GenevièveTeuton Professor of Medicineand Director of the Northwestern University CancerCenter. Dr. Rosen is a 1976 honors graduate of Northwestern University Medical School. After serving afellowship in clinical oncology at the National CancerInstitute, he joined the Northwestern faculty in 1981.He has specialized in tumor immunology and biological response modifier therapies, and has published125 papers on these and related subjects. In 1989, Dr.Rosen was appointed to the Directorship of the CancerCenter, succeeding Dr. Nathaniel Berlin, who servedas Director from 1975 to 1987.

The Center was founded in 1970 by Dr. John L.Brewer, a prominent leader in trophoblastic tumorsand currently Chairman Emeritus of the Departmentof Obstetrics and Gynecology. During Dr. Berlin's

tenure, laboratory and office space for the Center wasconstructed in the Health Sciences Building on the

university's Chicago campus. Comprehensive clinical

and basic science research programs were organized;additionally, a graduate training program in tumorcell biology was established.

A constant goal of the Center has been the coordination, cooperation, and integration of the wide rangeof experimental and clinical cancer research ongoingat Northwestern. Reflecting the separate locations ofthe university in Evanston and Chicago, the Center's

basic research activities are conducted at both themedical school and the main university campus. Clinical and preclinical investigations are performedwithin the university's affiliate hospitals, which include Northwestern Memorial, Children's Memorial,Evanston/Glenbrook, The Rehabilitation Institute ofChicago, and the Veterans' Administration Lakeside

Medical Center. The Kellogg Cancer Care Center,founded through the efforts of Edward F. Scanion,Professor Emeritus of Surgery, serves as a locusfor basic and clinical cancer research at EvanstonHospital.

Assisting Dr. Rosen is James Douglas Engel, Ph.D.,Deputy Director of Basic Science. He holds the OwenT. Coon Professorship in Molecular Biology. Dr.Engel heads a varied interdisciplinary program in viraland chemical carcinogenesis, intra/extracellular signalling, regulation of the immune system, differentiation and development, cytoskeleton cell motility andcell matrix, and DNA-protein interactions. SigmundA. Weitzman, M.D., is Deputy Director of ClinicalSciences and Professor of Medicine. Dr. Weitzmanheads the preclinical and clinical research programsthat are disease oriented. In addition, there are developing programs in bone marrow transplantation, rehabilitative aspects of cancer care, and cancer control.Altogether, the Center has 350 full and affiliate members. Information and photographs were kindly provided by Dr. Rosen.

Sidney Weinhouse