cbnÅ“rresearch · cbnÅ“rresearch volume 50 •¿number 16 •¿cnrea8 •¿pp...
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CbnÅ“rResearchVOLUME 50 •¿�NUMBER 16 •¿�CNREA8 •¿�PP 4829-5208
CONTENTS§
Asterisks # preceding page numbers refer to studies using human-derived material.
4829 Editorial. Carlo M. Croce, Editor-in-Chief.
Special Lecture
4830 The Final Common Pathway of Cancer: Presidential Address.Harris Busch.
4839 Short-Terni Metabolic Fate of L-["N|Glutamate in the Walker256 Carcinosarcoma in Vìvo.Sabina Filc-DeRicco, Alan S.Gelbard, Arthur J. L. Cooper, Karen C. Rosenspire, and EdwardNieves.
*4845 Low Proliferative Activity Is Associated with a Favorable Prog
nosis in PeripheralT-Cell Lymphoma.Helen L. Grierson,TerryN.Wooldridge, David T. Purtilo, Jene Pierson. Martin Bast, LesleeWooldridge, James O. Armitage, and Dennis D. Weisenburger.
*4849 Differential Effects of Phorbol Ester on Epidermal Growth Factor Receptors in Estrogen Receptor-positive and -negative BreastCancer Cell Lines. Masafumi Koga, Elizabeth A. Musgrove, andRobert L. Sutherland.
*4856 Molecular Characterization of a t(ll;14)(q23;q32) ChromosomeTranslocation in a B-Cell Lymphoma. Yukihiro Akao, YoshihideTsujimoto. Janet Finan, Peter C. Nowell, and Carlo M. Croce.
4860 In Vitro Determination of Uptake, Retention, Distribution, Biological Efficacy, and Toxicity of Boronated Compounds for Neutron Capture Therapy: A Comparison of Porphyrins with Sulf-hydryl Boron Hydrides. R. G. Fairchild. S. B. Kahl. B. H. Laster,J. Kalef-Ezra, and E. A. Popenoe.
*4866 Pharmacokinetics of the Mouse Monoclonal Antibody 17-1A inCancer Patients Receiving Various Treatment Schedules. Jan-Erik Frödin,Ann-Kari Lefvert, and HâkanMellstedt.
*4872 Serological Mapping of the TAG-72 Tumor-associated AntigenUsing 19 Distinct Monoclonal Antibodies. Masahide Kuroki,Philip D. Fernsten, David Wunderlich, David Colcher, Jean F.Simpson, Diane J. Poole, and Jeffrey Schlom.
*4880 Early Effects of Radiotherapy in Small Cell Lung Cancer Xeno-grafts Monitored by "P Magnetic Resonance Spectroscopy andBiochemical Analysis. Paul E. G. Kristjansen, Erik J. Pedersen,Bj0rn QuistortT, Folmer Filing, and Mogens Spang-Thomsen.
* 4885 Characterization of the Shed Form of the Human Tumor-associated Glycoprotein (TAG-72) from Serous Effusions of Patientswith Different Types of Carcinomas. Raju S. Katari, Philip D.Fernsten, and Jeffrey Schlom.
4891 Dual Mechanisms of Inhibition of DNA Synthesis by Triciribine.Linda L. Wotring. Leroy B. Townsend, Linda M. Jones.Katherine Z. Borysko, David L. Gildersleeve, and William B.Parker.
*4900 Antitumor Efficacy of PD115934 (NSC 366140) against SolidTumors of Mice. Patricia LoRusso, Antoinette J. Wozniak, LisaPolin, David Capps, Wilbur R. Leopold, Lester M. Werbel, LauraBiernat, Maria E. Dan, and Thomas H. Corbett.
*4906 In Vivo Induction of Lymphokine-activated Killer Cells by Inter-leukin-2 Splenic Artery Perfusion in Advanced Malignancy.Richard J. Klasa. Hulbert K. B. Silver, and Spencer Kong.
*4911 No Evidence for Point Mutations in Codons 12, 13, and 61 of theras Gene in a High-Incidence Area for Esophageal and GastricCancers. T. Victor. R. Du Toit, A. M. Jordaan. A. J. Bester, andP. D. van Helden.
*4915 Epidermal Growth Factor and Transforming Growth Factor a Induce Ascitic Fluid in Mice. Eiji Ohmura, Toshio Tsushima,Yoshinobu Kamiya. Masaki Okada, Noritaka Onoda. KazuoShizume. and Hiroshi Demura.
4918 Comparative Formation and Removal of Aflatoxin B,-DNA Ad-ducts in Cultured Mammalian Trachea! Epithelium. R. WayneBall, Dennis W. Wilson, and Roger A. Coulombe, Jr.
*4923 Expression of a Resistance Mechanism in Ovarian and CervicalCarcinomaCells Prevents Their Lysis by 7-Interferon. L. StewartMassad. David G. Mutch, C. Bethan Powell. Ming-Shian Kao.ano John Leslie Collins.
*4929 Effects of a Single Course of Deferoxamine in NeuroblastomaPatients. Alberto Donfrancesco, Giovanni Deb, Carlo Dominici,Domenico Fileggi. Manuel A. Castello, and Lawrence Helson.
4931 Inhibition by 7-Amino-n-butyric Acid and Baclofen of GastricCarcinogenesis Induced by ¿V-MethyI-Ar'-nitro-A'-nitrosoguan-
idine in Wistar Rats. Masaharu Tatsuta. Hiroyasu lishi, MiyakoBaba, Akihiko Nakaizumi. Makoto Ichii. and Haruo Taniguchi.
4935 Determinants of the Antitumor Effect of Radiolabeled Monoclonal Antibodies. S. J. Knox, R. Levy, R. A. Miller, W. Uhland,J. Schiele, W. Ruehl, R. Finston, P. Day-Lollini, and M. L. Goris.
* 4941 Expression of Endogenous Tumor Necrosis Factor as a ProtectiveProtein against the Cytotoxicity of Exogenous Tumor NecrosisFactor. Takeshi Himeno, Naoki Watanabe, Naofumi Yamauchi,Masahiro Maeda, Yasushi Tsuji, Tetsuro Okamoto. HiroshiNeda, and Yoshiro Niitsu.
4946 Flow Cytometric Characterizationof Antifolate Resistance in Cultured Mammalian Cells Using Fluoresceinated Methotrexate andDaunorubicin. Steven W. Sherwood, Yehuda G. Assaraf, ArturoMolina, and Robert T. Schimke.
*4951 Induction, Accumulation, and Persistence of Sister ('hruinâtid
Exchanges in Women with Breast Cancer Receiving Cyclo-phosphamide, Adriamycin, and 5-Fluorouracil Chemotherapy.James D. Tucker, Andrew J. Wyrobek, Linda K. Ashworth, MariL. Christensen. Gary V. Burton. Anthony V. Carrano, andRichard B. Everson.
*4957 Expression of Heterogeneous Profiles of Plasminogen Activators
and Plasminogen Activator Inhibitors by Human Glioma Lines.Robert G. Sitrin, Margaret R. Gyetko. Kerry L. Kole, PaulMcKeever, and James Varani.
*4962 Modulation of IdUrd-DNA Incorporation and Radiosensitizationin Human Bladder CarcinomaCells. Keith A. Kunugi. Miguel A.Vazquez-Padua, Elizabeth M. Miller, and Timothy J. Kinsella.
§The CONTENTS arranged by Subject Category can be found immediately following these CONTENTS.
on April 8, 2020. © 1990 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
* 4968 Human T-Lymphotropic Virus Type I Transcriptional Regulationby Methylation. Daniela Saggioro, Marina Panozzo, and LuigiChicco-Bianchi.
%4974 Tumor-promoting Activity of Staurosporine, a Protein Kinase Inhibitor on Mouse Skin. Shigeru Yoshizawa, Hirota Fujiki. HirokoSuguri. Masami Suganuma, Michie Nakayasu. Rie Matsushima.and Takashi Sugimura.
4979 Paracrine Growth Stimulation of Androgen-responsive ShionogiCarcinoma 115 by Its Autonomous Subline (Chiba Subline 2).Yuzo Furuya, Naohide Sato. Koichiro Akakura. TomohikoIchikawa. Noriaki Suzuki. Ryoko Sato, and Jun Shimazaki.
*4984 Presence of Cell Lineage-specific Hypomethylated Sites in theMajor Breakpoint Cluster Region. Craig E. Litz, Adam N.Goldfarb, John G. Strickler, and Richard D. Brunning.
4991 Identification of the Mouse Aldehyde Dehydrogenases Importantin Aldophosphamide Detoxification. Carl L. Manthey. Gregory J.Landkamer. and Norman E. Sladek.
^5003 Human Leukemic Myeloblasts and Myeloblastoid Cells Containthe Enzyme Cytidine S'-Monophosphate-A'-acetylneuraminicAcid:Gal/31-3GalNAc«(2-3)-sialyltransferase. Amila Kanani.D. Robert Sutherland. Eitan Fibach, Kushi L. Matta, AlexHindenburg. Inka Brockhausen. William Kuhns. Robert N.Taub, Dirk H. van den Eijnden. and Michael A. Baker.
* 5008 Role of the Mitochondria! Ac,-Complex in the Cytotoxic Action ofDiethylstilbestrol-Diphosphate toward Prostatic CarcinomaCells. Peter Schulz. Thomas A. Link. Laura Chaudhuri, andFriedrich Fittier.
*5013 Localization and Modulation of the DNA-binding Activity of theHuman c-ets-l Protooncogene. E. Shyam P. Reddy and Veena N.Rao.
* 5017 A Case-Control Study of Dietary and Nondietary Risk Factors forBreast Cancer in Shanghai. Yu Shun-Zhang, Lu Rui-Fang. XuDa-Dao. and Geoffrey R. Howe.
5022 Inhibition of Weight Loss by w-3 Fatty Acids in an ExperimentalCachexia Model. Michael J. Tisdale and Jasmin K. Dhesi.
*5027 Effects of Interleukin 2 Treatment Combined with Local Hyper-thermia in Mice Inoculated with Lewis Lung Carcinoma Cells.Rong-Nian Shen, Li Lu, Bo Wu, Homayoon Shidnia, Ned B.Hornback. and Hal E. Broxmeyer.
5031 Effects of Reoxygenation on Cells from Hypoxie Regions of SolidTumors: Analysis of Transplanted Murine Tumors for Evidenceof DNA Overreplication. S. D. Young and R. P. Hill.
5039 Serpin Inhibitors of Urokinase and Thrombin in Normal RatBrain and the 9L Brain Tumor: Evidence for Elevated Expressionof Protease Nexin I-like Inhibitor and a Novel Sodium DodecylSulfate-activated Tumor Antithrombin. J. S. Rao. J. B. Baker.R. A. Morantz. B. Kimler, R. Evans, and B. W. Festoff.
5045 Differential Effect of Ionizing Radiation on Transcription in Repair-deficientand Repair-proficient Mice. George P. Munson andGayle E. Woloschak.
^5049 Micronucleated Erythrocytes as an Index of Cytogenetic Damagein Humans: Demographic and Dietary Factors Associated withMicronucleated Erythrocytes in Splenectomized Subjects. DanielF. Smith, James T. MacGregor, Robert A. Hiatt, N. Kim Hooper,Carol M. Wehr. Beverly Peters. Lynn R. Goldman. Leslie A.Yuan, Philip A. Smith, and Charles E. Becker.
5055 Interaction of SR-4233 with Hyperthermia and Radiation in theFSalIC Murine Fibrosarcoma Tumor System in Vitro and inVivo. Terence S. Herman. Beverly A. Teicher, and C. NormanColeman.
*5060 Effect of Retinole Acid on Proliferation of Estrogen-responsiveTransformed Murine Leydig Cells in Serum-free Culture.Takahisa Hirose, Masafumi Koga. Haruhiko Kouhara, SusumuKishimoto, Keishi Matsumoto. and Bunzo Sato.
* 5065 Opposite Effect of Tumor Necrosis Factor a on Granulocyte Colony-stimulating Factor and Granulocyte-Macrophage Colony-stimulating Factor-dependent Growth of Normal and LeukemicHemopoietic Progenitors. Wanda Piacibello. Fiorella Sanavio.Antonella Severino, Silvia Morelli, Anna Maria Vaira, AlessandraStacchini, and Massimo Aglietta.
* 5072 Cytokine Regulation of Tumor Necrosis Factor-a and -ß(Lym-photoxin)-Messenger RNA Expression in Human PeripheralBlood MononuclearCells. Attan Kasid. Elaine P. Director.MarkC.Stovroff. Michael T. Lotze. and Steven A. Rosenberg.
5077 Endogenous and Exogenous Polyamines in Support of TumorGrowth. Nikolaus Seiler. Shakir Sarhan, Christine Grauffel.R. Jones. Bernd Knödgen.and J-P. Moulinoux.
5084 Chemoprevention of 1,2-Dimethylhydrazine-induced Colon Cancer in Mice by Naturally Occurring Organosulfur Compounds.Hiromichi Sumiyoshi and Michael J. Wargovich.
5088 Formation and Persistence of Novel Benzo(o)pyrene Adducts inRat Lung, Liver, and Peripheral Blood Lymphocyte DNA. JeffreyRoss. Garret Nelson. Andrew Kligerman. Gregory Erexson,Miriam Bryant, Karen Earley, Ramesh Gupta, and StephenNesnow.
* 5095 Pharmacokinetics and Toxicity of Two Schedules of High DoseEpirubicin. Sergei Alexei Tjuljandin. Rowan Grant Doig,Mordechai Motty Sobol. Douglas MacGregor Watson, WilliamPatrick Sheridan. George Morstyn, George Mihaly, and MichaelDavid Green.
* 51(12 Implantation of Genetically Manipulated Fibroblasts into Mice asAntitumor a-Interferon Therapy. Hiromi Ogura. KenzaburoTani. Keiya Ozawa. Shigekazu Nagata. Shigetaka Asano, andFumimaro Takaku.
5107 Use of Intracellular H3 Messenger RNA as a Marker to Determine the Proliferation Pattern of Normal and 7,12-Dimethyl-benz|fl]anthracene-transformed Hamster Oral Epithelium.David T. W. Wong. Ming Yung Chou. Long-Chang Chang, andGeorge T. Gallagher.
*5112 Quantitative Cytochemical Detection of Malignant and Potentially Malignant Cells in the Colon. Alistair James Best. PranabK. Das. Hitendra R. H. Patel. and Cornelis J. F. Van Noorden.
*5119 Enhancement of Hyperthermic Damage on M14 MelanomaCells by Liposome Pretreatment. N. Laudonio, L. Marcocci.G. Arancia, A. Calcabrini. D. Del Bufalo, C. Greco. G. Zupi.I. Mavelli, J. Z. Pedersen. A. Bozzi, and B. Mondovi.
5127 DNA Synthesis, Apoptosis, and Phenotypic Expression as Determinants of Growth of Altered Foci in Rat Liver during Phénobarbital Promotion. Rolf Schulte-Hermann, Irene Timmermann-Trosiener. Gertrud Barthel, and Wilfried Bursch.
5136 Role of (±)-l,2-Bis(3,5-dioxopiperazinyl-l-yl)propane (ICRF-187) in Modulating Free Radical Scavenging Enzymes in Doxo-rubicin-induced Cardiomyopathy. Peggy Alderton, Janet Gross,and Michael D. Green.
*5143 Keratin Subtypes in Carcinomas of the Uterine Cervix: Implications for Histogenesis and Differential Diagnosis. Dagmar Ivanyi.Els Groeneveld. Greet Van Doornewaard. Woher J. Mooi, andPhilomena C. Hageman.
5153 Cytotoxicity of Long and Short Crocidolite Asbestos Fibers inVitro and in Vivo. Lee A. Goodglick and Agnes B. Kane.
5164 Evaluation of the Effect of Suramin on Neural Cell Growth andN-CAM Expression. Xiao-Jun Guo, Jacques Fantini, RegineRoubin. Jacques Marvaldi, and GenevièveRougon.
on April 8, 2020. © 1990 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
5171 Progressive State Selection of Cells in Low Serum PromotesHigh Density Growth and N'eoplastic Transformation in NIH
3T3 Cells. Adam Yao. Andrew L. Rubin, and Harry Rubin.
*5177 In y¡troDifferentiation of Human Neuroblastoma Cells Causedby Vasoactive Intestinal Peptide. Jeffrey C. Pence and NicholasA. Shorter.
*5184 pISS1"'"Expression in Human Lung Adenocarcinomas Predicts
Shortened Survival. Jeffrey A. Kern. David A. Schwartz. JoanneE. Nordberg. David B. Weiner, Mark I. Greene. Lisa Torney. andRobert A. Robinson.
*5192 Human Monoclonal Antibody against a Tissue Polypeptide Antigen-related Protein from a Patient with a Signet-Ring Cell Carcinoma of the Stomach. Martin Pfaff. Rosemary O'Connor.
H. Peter Vollmers. and Hans Konrad Müller-Hermelink.
*5199 Specific Uptake of the Auger Electron-emitting Thymidine Analogue 5-|l2'I/125IlIodo-2'-deoxyuridine in Rat Brain Tumors: Di
agnostic and Therapeutic Implications in Humans. Amin I.Kassis. Annick D. Van den Abbeele. Patrick Y. C. Wen. JaninaBaranowska-Kortylewicz. Rebecca A. Aaronson. William C.DeSisto. Lois A. Lampson. Peter McL. Black, and S. JamesAdelstein.
Letter to the Editor
5204 Correspondence re: David L. Becton and Barbara Roberts. Anti-leukemic Effects of Deferoxamine on Human Myeloid LeukemiaCell Lines. Cancer Res., 49: 4809-4812, 1989. Martin Poot andHolger Hoehn. Reply by David L. Becton.
5205 AnnouncementsEighty-second Annual Meeting of the AACRCall for Nominations for the Scientific Awards of the AACRAACR Special Conferences in Cancer ResearchFuture Annual Meetings of the AACRCalendar of Events
5207 Author Index
NOTE: AACR forms available in the back of this issue—•¿�Application for Active and Corresponding Membership•¿�Application for Associate Membership
on April 8, 2020. © 1990 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
Cancer Research
VOLUME 50 •¿�NUMBER 16
CONTENTS Arranged by Subject Category
4829 Editorial. Carlo M. Croce. Editor-in-Chief.
Special Lecture
4830 The Final Common Pathway of Cancer: Presidential Address.Harris Busch.
BASIC SCIENCES
Biochemistry and Biophysics4839 Short-Term Metabolic Fate of L-|13N|Glutamate in the Walker
256 Carcinosarcoma in Vivo. Sabina Filc-DeRicco. Alan S.Gelbard. Arthur J. L. Cooper. Karen C. Rosenspire, and EdwardNieves.
*4849 Differential Effects of Phorbol Ester on Epidermal Growth Factor Receptors in Estrogen Receptor-positive and -negative BreastCancer Cell Lines. Masafumi Koga. Elizabeth A. Musgrove, andRobert L. Sutherland.
*5IMM Human Leukemic Myeloblasts and Myeloblastoid Cells Containthe Enzyme Cytidine 5'-Monophosphate-/V-acetylneuraminicAcid:Gal/31-3GalNAca(2-3)-sialyltransferase. Amita Kanani.D. Robert Sutherland. Eitan Fibach, Kushi L. Matta, AlexHindenburg. Inka Brockhausen, William Kuhns. Robert N.Taub. Dirk H. van den Eijnden. and Michael A. Baker.
Carcinogenesis
*4911 No Evidence for Point Mutations in Codons 12, 13, and 61 of theras Gene in a High-Incidence Area for Esophageal and GastricCancers. T. Victor. R. Du Toit. A. M. Jordaan. A. J. Bester, andP. D. van Helden.
4918 Comparative Formation and Removal of Aflatoxin B,-DNA Ad-ducts in Cultured Mammalian Trachea! Epithelium. R. WayneBall. Dennis W. Wilson, and Roger A. Coulombe. Jr.
4931 Inhibition by 7-Amino-n-butyric Acid and Baclofen of GastricCarcinogenesis Induced by /V-Methyl-/V'-nitro-/V-nitrosogua-
nidine in Wistar Rats. Masaharu Tatsuta, Hiroyasu lishi, MiyakoBaba, Akihiko Nakaizumi. Makoto Ichii. and Haruo Taniguchi.
* 4')74 Tumor-promoting Activity of Staurosporine, a Protein Kinase Inhibitor on Mouse Skin. Shigeru Yoshizawa. Hirota Fujiki. HirokoSuguri. Masami Suganuma, Michie Nakayasu. Rie Matsushima.and Takashi Sugimura.
5084 Chemoprevention of 1,2-Dimethylhydrazine-induced Colon Cancer in Mice by Naturally Occurring Organosulfur Compounds.Hiromichi Sumiyoshi and Michael J. Wargovich.
5088 Formation and Persistence of Novel Benzo(a)pyrene Adducts inRat Lung, Liver, and Peripheral Blood Lymphocyte DNA. JeffreyRoss, Garret Nelson. Andrew Kligerman, Gregory Erexson,Miriam Bryant, Karen Earley, Ramesh Gupta, and StephenNesnow.
5107 Use of Intracellular H3 Messenger RNA as a Marker to Determine the Proliferation Pattern of Normal and 7,12-Dimeth-ylbenz|a|anthracene-transformed Hamster Oral Epithelium.David T. W. Wong. Ming Yung Chou. Long-Chang Chang, andGeorge T. Gallagher.
5127 DNA Synthesis, Apoptosis, and Phenotypic Expression as Determinants of Growth of Altered Foci in Rat Liver during Phénobarbital Promotion. Rolf Schulte-Hermann. Irene Timmermann-Trosiener, Gertrud Barthel, and Wilfried Bursch.
5153 Cytotoxicity of Long and Short Crocidolite Asbestos Fibers iny ¡troand in Vivo. Lee A. Goodglick and Agnes B. Kane.
Endocrinology
4979 Paracrine Growth Stimulation of Androgen-responsive ShionogiCarcinoma 115 by Its Autonomous Subline (Chiba Subline 2).Yuzo Furuya, Naohide Sato, Koichiro Akakura, TomohikoIchikawa, Noriaki Suzuki, Ryoko Sato, and Jun Shimazaki.
*5060 Effect of Retinole Acid on Proliferation of Estrogen-responsiveTransformed Murine Leydig Cells in Serum-free Culture.Takahisa Hirose, Masafumi Koga, Haruhiko Kouhara, SusumuKishimoto, Keishi Matsumoto, and Bunzo Sato.
Immunology
*4872 Serological Mapping of the TAG-72 Tumor-associated AntigenUsing 19 Distinct Monoclonal Antibodies. Masahide Kuroki,Philip D. Fernsten, David Wunderlich, David Colcher, Jean F.Simpson, Diane J. Poole, and Jeffrey Schlom.
* 4885 Characterization of the Shed Form of the Human Tumor-associated Glycoprotein (TAG-72) from Serous Effusions of Patientswith Different Types of Carcinomas. Raju S. Katari, Philip D.Fernsten, and Jeffrey Schlom.
^4906 In Vivo Induction of Lymphokine-activated Killer Cells by Inter-leukin-2 Splenic Artery Perfusion in Advanced Malignancy.Richard J. Klasa, Hulbert K. B. Silver, and Spencer Kong.
* 5072 Cytokine Regulation of Tumor Necrosis Factor-«and -ß(Lym-photoxin)-Messenger RNA Expression in Human PeripheralBlood MononuclearCells. Attan Kasid, Elaine P. Director,Mark C.Stovroff, Michael T. Lotze, and Steven A. Rosenberg.
Molecular Biology and Genetics
*4856 Molecular Characterization of a t(ll:14)(q23;q32) ChromosomeTranslocation in a B-Cell Lymphoma. Yukihiro Akao, YoshihideTsujimoto, Janet Finan, Peter C. Nowell, and Carlo M. Croce.
*4984 Presence of Cell Lineage-specific Hypomethylated Sites in theMajor Breakpoint Cluster Region. Craig E. Litz, Adam N.Goldfarb, John G. Strickler, and Richard D. Brunning.
* 5013 Localization and Modulation of the DNA-binding Activity of theHuman c-ets-l Protooncogene. E. Shyam P. Reddy and Veena N.Rao.
5045 Differential Effect of Ionizing Radiation on Transcription in Repair-deficientand Repair-proficient Mice. George P. Munson andGayle E. Woloschak.
Preclinical Pharmacology and Experimental Therapeutics
4860 In Vitro Determination of Uptake, Retention, Distribution, Biological Efficacy, and Toxicity of Boronated Compounds for Neutron Capture Therapy: A Comparison of Porphyrins with Sulf-hydryl Boron Hydrides. R. G. Fairchild, S. B. Kahl, B. H. Laster,J. Kalef-Ezra, and E. A. Popenoe.
*4880 Early Effects of Radiotherapy in Small Cell Lung Cancer Xeno-grafts Monitored by 31P Magnetic Resonance Spectroscopy andBiochemical Analysis. Paul E. G. Kristjansen, Erik J. Pedersen,Bj0rn Quistorff, Folmer Elling, and Mogens Spang-Thomsen.
1Indicates studies using human-derived material.
on April 8, 2020. © 1990 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
4891 Dual Mechanisms of Inhibition of DNA Synthesis by Triciribine.Linda L. Wotring, Leroy B. Townsend, Linda M. Jones,Katherine Z. Borysko, David L. Gildersleeve, and William B.Parker.
*4900 Antitumor Efficacy of PD115934 (NSC 366140) against SolidTumors of Mice. Patricia LoRusso, Antoinette J. Wozniak, LisaPolin, David Capps, Wilbur R. Leopold, Lester M. Werbel, LauraBiernat, Maria E. Dan, and Thomas H. Corbett.
4935 Determinants of the Antitumor Effect of Radiolabeled Monoclonal Antibodies. S. J. Knox, R. Levy, R. A. Miller, W. Uhland,J. Schiele, W. Ruehl, R. Finston, P. Day-Lollini, and M. L. Goris.
4946 Flow Cytometric Characterizationof Antifolate Resistance in Cultured Mammalian Cells Using Fluoresceinated Methotrexate andDaunorubicin. Steven W. Sherwood, Yehuda G. Assaraf, ArturoMolina, and Robert T. Schimke.
^ 4962 Modulation of IdUrd-DNA Incorporation and Radiosensitizationin Human Bladder Carcinoma Cells. Keith A. Kunugi, Miguel A.Vazquez-Padua, Elizabeth M. Miller, and Timothy J. Kinsella.
4991 Identification of the Mouse Aldehyde Dehydrogenases Importantin Aldophosphamide Detoxification. Carl L. Manthey, Gregory J.Landkamer, and Norman E. Sladek.
* 5008 Role of the Mitochondrial Ac,-Complex in the Cytotoxic Action ofDiethylstilbestrol-Diphosphate toward Prostatic CarcinomaCells. Peter Schulz, Thomas A. Link, Laura Chaudhuri, andFriedrich Fittier.
* 5027 Effects of Interleukin 2 Treatment Combined with Local Hyper-thermia in Mice Inoculated with Lewis Lung Carcinoma Cells.Rong-Nian Shen, Li Lu, Bo Wu, Homayoon Shidnia, Ned B.Hornback, and Hal E. Broxmeyer.
5055 Interaction of SR-4233 with Hyperthermia and Radiation in theFSallC Murine Fibrosarcoma Tumor System in Vitro and inVivo. Terence S. Herman, Beverly A. Teicher, and C. NormanColeman.
5077 Endogenous and Exogenous Polyamines in Support of TumorGrowth. Nikolaus Seiler, Shakir Sarhan, Christine Grauffel,R. Jones, Bernd Knödgen,and J-P. Moulinoux.
* 5102 Implantation of Genetically Manipulated Fibroblasts into Mice asAntitumor a-Interferon Therapy. Hiromi Ogura, KenzaburoTani, Keiya Ozawa, Shigekazu Nagata, Shigetaka Asano, andFumimaro Takaku.
Enhancement of Hyperthermic Damage on M14 MelanomaCells by Liposome Pretreatment. N. Laudonio, L. Marcocci,G. Arancia, A. Calcabrini, D. Del Bufalo, C. Greco, G. Zupi,I. Mavelli, J. Z. Pedersen, A. Bozzi, and B. Mondovi.
5136 Role of (±)-l,2-Bis(3,5-dioxopiperazinyl-l-yl)propane (ICRF-187) in Modulating Free Radical Scavenging Enzymes in Dox-orubicin-induced Cardiomyopathy. Peggy Alderton, Janet Gross,and Michael D. Green.
5164 Evaluation of the Effect of Suramin on Neural Cell Growth andN-CAM Expression. Xiao-Jun Guo, Jacques Fantini, RégineRoubin, Jacques Marvaldi, and GenevièveRougon.
*5199 Specific Uptake of the Auger Electron-emitting Thymidine Analogue 5-[123I/125I)Iodo-2'-deoxyuridinein Rat Brain Tumors: Di
agnostic and Therapeutic Implications in Humans. Amin I.Kassis, Annick D. Van den Abbeele, Patrick Y. C. Wen, JaninaBaranowska-Kortylewicz, Rebecca A. Aaronson, William C.DeSisto, Lois A. Lampson, Peter McL. Black, and S. JamesAdelstein.
Tumor Biology
*4915 Epidermal Growth Factor and Transforming Growth Factor a Induce Ascitic Fluid in Mice. Eiji Ohmura, Toshio Tsushima,Yoshinobu Kamiya, Masaki Okada, Noritaka Onoda, KazuoShizume, and Hiroshi Demura.
* 4923 Expression of a Resistance Mechanism in Ovarian and CervicalCarcinomaCells Prevents Their Lysis by 7-Interferon. L. StewartMassad, David G. Mutch, C. Bethan Powell, Ming-Shian Kao,and John Leslie Collins.
* 4941 Expression of Endogenous Tumor Necrosis Factor as a ProtectiveProtein against the Cytotoxicity of Exogenous Tumor NecrosisFactor. Takeshi Himeno, Naoki Watanabe, Naofumi Yamauchi,Masahiro Maeda, Yasushi Tsuji, Tetsuro Okamoto, HiroshiNeda, and Yoshiro Niitsu.
* 4957 Expression of Heterogeneous Profiles of Plasminogen Activatorsand Plasminogen Activator Inhibitors by Human Glioma Lines.Robert G. Sitrin, Margaret R. Gyetko, Kerry L. Kole, PaulMcKeever, and James Varani.
5022 Inhibition of Weight Loss by u-3 Fatty Acids in an ExperimentalCachexia Model. Michael J. Tisdale and Jasmin K. Dhesi.
5031 Effects of Reoxygenation on Cells from Hypoxie Regions of SolidTumors: Analysis of Transplanted Murine Tumors for Evidenceof DNA Overreplication. S. D. Young and R. P. Hill.
5039 Serpin Inhibitors of Urokinase and Thrombin in Normal RatBrain and the 9L Brain Tumor: Evidence for Elevated Expressionof Protease Nexin I-like Inhibitor and a Novel Sodium DodecylSulfate-activated Tumor Antithrombin. J. S. Rao, J. B. Baker,R. A. Morantz, B. Kimler, R. Evans, and B. W. Festoff.
* 5065 Opposite Effect of Tumor Necrosis Factor a on Granulocyte Colony-stimulating Factor and Granulocyte-Macrophage Colony-stimulating Factor-dependent Growth of Normal and LeukemicHemopoietic Progenitors. Wanda Piacibello, Fiorella Sanavio,Antonella Severino, Silvia Morelli, Anna Maria Vaira, AlessandraStacchini, and Massimo Aglietta.
Quantitative Cytochemical Detection of Malignant and Potentially Malignant Cells in the Colon. Alistair James Best, PranabK. Das, Hitendra R. H. Patel, and Cornelis J. F. Van Noorden.
*5143 Keratin Subtypes in Carcinomas of the Uterine Cervix: Implications for Histogenesis and Differential Diagnosis. Dagmar Ivanyi,Els Groeneveld, Greet Van Doornewaard. Woher J. Mooi, andPhilomena C. Hageman.
5171 Progressive State Selection of Cells in Low Serum PromotesHigh Density Growth and Neoplastic Transformation in NIH3T3 Cells. Adam Yao, Andrew L. Rubin, and Harry Rubin.
^5177 In Vitro Differentiation of Human Neuroblastoma Cells Causedby Vasoactive IntestinalPeptide. JeffreyC. Pence and Nicholas A.Shorter.
^5184 plSS"*"Expression in Human Lung Adenocarcinomas PredictsShortened Survival. Jeffrey A. Kern, David A. Schwartz, JoanneE. Nordberg, David B. Weiner, Mark I. Greene, Lisa Torney, andRobert A. Robinson.
*5192 Human Monoclonal Antibody against a Tissue Polypeptide Antigen-related Protein from a Patient with a Signet-Ring Cell Carcinoma of the Stomach. Martin Pfaff, Rosemary O'Connor,
H. Peter Vollmers. and Hans Konrad Müller-Hermelink.
Virology
4968 Human T-Lymphotropic Virus Type I Transcriptional Regulationby Methylation. Daniela Saggioro, Marina Panozzo, and LuigiChicco-Bianchi.
CLINICAL AND EPIDEMIOLOGICALINVESTIGATIONS
Clinical
4845 Low Proliferative Activity Is Associated with a Favorable Prognosis in Peripheral T-Cell Lymphoma. Helen L. Grierson, TerryN. Wooldridge, David T. Purtilo, Jene Pierson, Martin Bast,Leslee Wooldridge, James O. Armitage, and Dennis D.Weisenburger.
on April 8, 2020. © 1990 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
4866 Pharmacokinetics of the Mouse Monoclonal Antibody 17-1A inCancer Patients Receiving Various Treatment Schedules. Jan-Erik Frödin,Ann-Kari Lefvert. and HâkanMellstedt.
4929 Effects of a Single Course of Deferoxamine in NeuroblastomaPatients. Alberto Donfrancesco. Giovanni Deb. Carlo Dominici.Domenico Fileggi. Manuel A. Castello, and Lawrence Helson.
5095 Pharmacokinetics and Toxicity of Two Schedules of High DoseKpirubicin. Sergei Alexei Tjuljandin. Rowan Grant Doig,Mordechai Motty Sobol, Douglas MacGregor Watson. WilliamPatrick Sheridan. George Morstyn. George Mihaly. and MichaelDavid Green.
Epidem iological
4951 Induction, Accumulation, and Persistence of Sister ChromatidExchanges in Women with Breast Cancer Receiving Cyclo-phosphamide, Adriamycin, and 5-Eluorouracil Chemotherapy.James D. Tucker. Andrew J. Wyrobek, Linda K. Ashworth. ManL. Christensen. Gary V. Burton. Anthony V. Carrano, andRichard B. Everson.
5017 A Case-Control Study of Dietary and Nondietary Risk Factors forBreast Cancer in Shanghai. Yu Shun-Zhang, Lu Rui-Fang. XuDa-Dao. and Geoffrey R. Howe.
5049 Micronucleated Erythrocytes as an Index of Cytogenetic Damagein Humans: Demographic and Dietary Factors Associated withMicronucleated Erythrocytes in Splenectomized Subjects. DanielF. Smith. James T. MacGregor. Robert A. Hiatt. N. Kim Hooper,Carol M. Wehr, Beverly Peters, Lynn R. Goldman, Leslie A.Yuan, Philip A. Smith, and Charles E. Becker.
Letter to the Editor
5204 Correspondence re: David L. Becton and Barbara Roberts. Anti-leukemic Effects of Deferoxamine on Human Myeloid LeukemiaCell Lines. Cancer Res., 49: 4809-4812, 1989. Martin Pool andHolger Hoehn. Reply by David L. Becton.
5205 AnnouncementsEighty-second Annual Meeting of the AACRCall for Nominations for the Scientific Awards of the AACRAACR Special Conferences in Cancer ResearchFuture Annual Meetings of the AACRCalendar of Events
5207 Author Index
NOTE: AACR forms available in the back of this issue—•¿�Application for Active and Corresponding Membership•¿�Application for Associate Membership
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1990;50:4829-5207. Cancer Res 50 (16)
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