Curare and Related Compounds

George Hsiao

2008

Therapeutic uses of anti-ChE agents

(1) Paralytic Ileus and Atony of the Urinary Bladder: Neostigmine is used for the relief of abdominal distension and acute colonic pseudoobstruction from a variety of medical and surgical causes.

(2)   Glaucoma and Other Ophthalmologic Indication

(3)   Myasthenia Gravis

(4) Prophylaxis in Cholinesterase Inhibitor Poisoning (nerve gas: pyridostigmine)

(5) Intoxication by Anticholinergic Drugs (atropine: CNS effects: physostigmine)

(6)   Alzheimer’s Disease (tacrine, donepezil)

Myasthenia Gravis vs Normal Condition

Neurofibrillary Tangles and Senile Plaques

Cholinergic Innervation

Therapeutics on Alzheimer’s disease •  Cholinergic drugs• Ach E inhibitors• Tacrine• Donepezil• Rivastigmine• Galantamine

Terrorism !!!