nitric oxide (nitrogen monoxide) endothelial relaxing factor (edrf). * 組員 b9902080 廖佩炫...
TRANSCRIPT
![Page 1: Nitric Oxide (Nitrogen monoxide) Endothelial Relaxing Factor (EDRF). * 組員 B9902080 廖佩炫 B9902095 盧翰生](https://reader033.vdocuments.site/reader033/viewer/2022061501/56649cc15503460f94988e78/html5/thumbnails/1.jpg)
Nitric Oxide (Nitrogen monoxide)Endothelial Relaxing Factor (EDRF).
* 組員B9902080 廖佩炫B9902095 盧翰生
![Page 2: Nitric Oxide (Nitrogen monoxide) Endothelial Relaxing Factor (EDRF). * 組員 B9902080 廖佩炫 B9902095 盧翰生](https://reader033.vdocuments.site/reader033/viewer/2022061501/56649cc15503460f94988e78/html5/thumbnails/2.jpg)
How nitric oxide is produced? L-arginine + 3/2 NADPH + H+ + 2 O2
citrulline + nitric oxide + 3/2 NADP+
![Page 3: Nitric Oxide (Nitrogen monoxide) Endothelial Relaxing Factor (EDRF). * 組員 B9902080 廖佩炫 B9902095 盧翰生](https://reader033.vdocuments.site/reader033/viewer/2022061501/56649cc15503460f94988e78/html5/thumbnails/3.jpg)
How nitric oxide is produced?
• Reduction of inorganic nitrate
• By Nitroglycerin and amyl nitrite
• Nitric oxide is generated by phagocytes
• Nitric oxide is released by neurons
1.Unrelated to body
2.related to body
![Page 4: Nitric Oxide (Nitrogen monoxide) Endothelial Relaxing Factor (EDRF). * 組員 B9902080 廖佩炫 B9902095 盧翰生](https://reader033.vdocuments.site/reader033/viewer/2022061501/56649cc15503460f94988e78/html5/thumbnails/4.jpg)
Effects of nitric oxide to the human body; Vasodilation.(Penile Erection)
Mechanisms of NO Action NO is formed
diffuses into the blood
diffuses into the muscle cells
activates guanylyl cyclase
dephosphorylation of GTP
signalling smooth muscle relaxation
![Page 5: Nitric Oxide (Nitrogen monoxide) Endothelial Relaxing Factor (EDRF). * 組員 B9902080 廖佩炫 B9902095 盧翰生](https://reader033.vdocuments.site/reader033/viewer/2022061501/56649cc15503460f94988e78/html5/thumbnails/5.jpg)
Effects of nitric oxide to the human body; Neurotransmission
Modifying electrical activity of neurons
![Page 6: Nitric Oxide (Nitrogen monoxide) Endothelial Relaxing Factor (EDRF). * 組員 B9902080 廖佩炫 B9902095 盧翰生](https://reader033.vdocuments.site/reader033/viewer/2022061501/56649cc15503460f94988e78/html5/thumbnails/6.jpg)
Carbon monoxide Carbonous oxide
![Page 7: Nitric Oxide (Nitrogen monoxide) Endothelial Relaxing Factor (EDRF). * 組員 B9902080 廖佩炫 B9902095 盧翰生](https://reader033.vdocuments.site/reader033/viewer/2022061501/56649cc15503460f94988e78/html5/thumbnails/7.jpg)
How is carbon monoxide produced• Generated by the enzyme heme oxygenase
(HO) (where it is found in the neurons in the brain or PNS ) - first example
• Vertebrate body produces small amount of CO
• During heme metabolism
![Page 8: Nitric Oxide (Nitrogen monoxide) Endothelial Relaxing Factor (EDRF). * 組員 B9902080 廖佩炫 B9902095 盧翰生](https://reader033.vdocuments.site/reader033/viewer/2022061501/56649cc15503460f94988e78/html5/thumbnails/8.jpg)
Production of the Carbon Monoxide
![Page 9: Nitric Oxide (Nitrogen monoxide) Endothelial Relaxing Factor (EDRF). * 組員 B9902080 廖佩炫 B9902095 盧翰生](https://reader033.vdocuments.site/reader033/viewer/2022061501/56649cc15503460f94988e78/html5/thumbnails/9.jpg)
Effects of Carbon monoxide Vasodilation Carbon Monoxide produced
activation of calcium-activated potassium channels
inducing hyperpolarizing outward currents called STOCs
smooth muscle hyper-polarization
Vasodilation
![Page 10: Nitric Oxide (Nitrogen monoxide) Endothelial Relaxing Factor (EDRF). * 組員 B9902080 廖佩炫 B9902095 盧翰生](https://reader033.vdocuments.site/reader033/viewer/2022061501/56649cc15503460f94988e78/html5/thumbnails/10.jpg)
參考資料http://www.google.com.tw/images?um=1&hl=zh-TW&biw=1076&bih=412&tbs=isch%3A1&sa=1&q=MUSCLE+CELL&aq=f&aqi=g1&aql=&oq=http://en.wikipedia.org/wiki/Carbon_monoxidehttp://en.wikipedia.org/wiki/Hemehttp://nitricoxidewarning.com/nitric-oxide-supplements-find-the-best-nitric-oxide-supplement/http://www.bewellbuzz.com/general/amazing-benefits-nitric-oxide/http://blog.udn.com/jnwu/3958716http://www.forcefactorsuccess.com/best-nitric-oxide-supplementshttp://www.phagocytes.net/groups/erwig.htmlhttp://www.boatingsidekicks.com/cobro/cobrochure.htmhttp://www.cdc.gov/co/faqs.htmhttp://www.sigmaaldrich.com/life-science/metabolomics/enzyme-explorer/learning-center/plasma-blood-protein/hemoglobin-heme-products.htmlhttp://psychology.kenyon.edu/psy_111/week5.htmhttp://jap.physiology.org/content/100/3/1065.fullhttp://jap.physiology.org/content/100/3/1065/F1.expansion.htmlhttp://ajrccm.atsjournals.org/cgi/content/full/171/4/354http://en.wikipedia.org/wiki/Myosin_light_chain_phosphatase