New analgesic delivery system gets under the skin

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  • 10 RESEARCH & DEVELOPMENT

    New analgesic delivery system gets under the skin

    Effective local anaesthesia without injection is to be made possible with a new drug delivery system, report German and Spanish investigators.

    Small particles consisting of an aqueous compartment surrounded by a lipid bilayer, transfersomes, allow rapid delivery of anaesthetic to the deep layers of the epidermis and dermis. The analgesic effectiveness of the preparation was equal to subcutaneous injection in rats.

    In humans, complete local anaesthesia was achieved in 30 min with tetracaine transfersomes and in 90 min with lidocaine transfersomes. Local anaesthesia was maintained for over 4 hours.

    The study authors conclude that transfersomes 'offer a suitable means for the noninvasive treatment of local pain on direct, topical drug application' . Planas ME. Gonzalez P. Rodriguez L. Sanchez S, Cevc G. Noninvasive percutaneous induction of topical analgesia by a new type of drug carrier. and prolongation of local pain insensitivity by anesthetic liposomes. Anesthesia and Analgesia 75: 615-621. Oct 1992 .. '1I"3/>7

    31 Oct 1982 INPHARMAe ISSN 0156-270319211031-OO101$1.00c Adlalntemetlonel Ltd

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