msk imaging_1.bone tumor mimickers china_by dr. jim wu
TRANSCRIPT
Bone Tumor Mimickers
Jim Wu, MD
Beth Israel Deaconess Medical Center Harvard Medical School
Boston, MA
Disclosures
– Kaneka Corp - research funding support
– Boehringer Ingelheim - research funding support
– PharmaMar - imaging consultant
Learning Objectives
• Learn the definition of a bone tumor mimicker
• Learn the categories of bone tumor mimickers
• Learn the key imaging and clinical features of bone tumor mimickers in order to prevent inappropriate treatment
Bone Tumor Mimicker
• Definition of “Mimicker”
– to be an imitation of, simulate; resemble closely
• “Bone tumor mimicker” - any lesion in bone that looks like a bone tumor
-Merriam-Webster Dictionary
Case 1
Case 2
T1 T2 fat sat
Case 3
Case 4
Bone Tumor Mimicker
• Many lesions in bone can be mistaken for a tumor
• Important to know the common mimickers in order to prevent misdiagnosis and inappropriate treatment
• Do not want to subject patient to unnecessary tests and anxiety
Classification of Bone Tumor Mimickers
• Normal variants
• Congenital/developmental
• Trauma
• Metabolic/Arthritic
• Infection
• Iatrogenic
• Technical artifacts
Normal variants
•Red marrow
•Ward’s triangle in femur
•Humeral pseudocyst
•Calcaneal pseudotumor
T1 T2 fat sat
Lesion hyperintense to muscle on T1
Abnormal Marrow - Lymphoma
T1 T2 FS
Key Point: Red marrow should not be hypointense to normal skeletal muscle on T1
Red Marrow
• Normal marrow transitions from red to yellow (fatty) marrow with increasing age
• Islands of red marrow can remain, especially in the metaphysis of long bones
• Red marrow should be more hyperintense than skeletal muscle on T1 weighted images
• Red marrow should not extend into the epiphysis, stopping at the physeal scar
Red Marrow
Ends at physeal scar
B Cell Lymphoma
T1 T2 FS
Ward’s triangle
• Triangular area of lucency in femoral neck
• Outlined by the compressive and tensile trabecular lines
• Less apparent in osteoporotic patients due to loss of trabecular lines
• NORMAL FINDING!
Humeral pseudocyst
• Lucent area in the superolateral aspect of the humeral head
• Due to normal decrease in trabecular lines and often contains more fat than the rest of the humeral head
• Best seen on external rotation views
Normal fat
Pseudocyst in the anterior calcaneus
• Lucency in the body/anterior aspect of the calcaneus can appear in an area between major trabecular groups
Intraosseous Lipoma
Congenital/ developmental
•Synovial herniation pit in proximal femur (Pitt’s pit)
•Supracondylar process of humerus
•Soleal line on tibia
Synovial herniation pit in proximal femur (Pitt’s pit)
• Dr. Michael Pitt in 1982• Anterosuperior aspect of the
femoral neck• Rounded lucent lesion with a
thin sclerotic rim• ?? normal variants or due to
mechanical abrasion of hip capsule with femoral neck
• Associated with femoral acetabular impingement (FAI) syndrome
Supracondylar process of the humerus
-Bony spur arising from the anteromedial aspect of the humerus
-1-3% of population
-Phylogenetic vestige of the supracondyloid foramen
-Incidental finding and should not be mistaken for an osteochondroma or surface osteosarcoma
-Ligament of Struthers can form fibrous tunnel which compresses median nerve and/or brachial artery
Supracondylar process of the humerus
http://www.abdn.ac.uk/zoohons/struthers/ligament1.htihttp://www.abdn.ac.uk/zoohons/struthers/ligament1.hti
Soleal line
Soleal line
• A tug lesion at the origin of the soleus muscle
• Can mimic periostitis from trauma, tumor or infection
• The cortical thickening extends lateral to medial down the posterior upper one-thirds of the tibia
• Similar changes can be seen at the fibular attachment of the soleus
Soleal line
Stress Fracture Osteoid OsteomaSoleal Line
Trauma
• Subperiosteal hematoma
• Stress fracture
• Myositis ossificans
T1
Subperiosteal hematoma
• Surface bone lesion caused by bleeding in the periosteum
• Periosteum is highly vascular and closely adherent to the bone
• Often resolve with no sequela; however, lesions that persist can ossify
Stress Fracture
• Overuse injuries caused by repeated stress to bone
• (1) insufficiency fractures occur when normal stress is applied to pathologically weakened bone
• (2) fatigue fractures occur where excessive repetitive force is applied to normal bone
Stress Fracture
Resolved6 months later
Myositis Ossificans
Myositis Ossificans
• Most common form of heterotopic ossification in muscle • Predisposing factors: burns, paraplegia, surgery, traumatic
brain injury, hemophilia, ankylosing spondylitis, DISH• Patients often cannot recall previous trauma • Most lesions arise in the large muscles of the extremities• Calcification is rarely seen on radiographs in the first few
weeks• Peripheral “zonal” ossification pattern• Early-stage myositis ossificans can enhance and can be
mistaken for a soft tissue sarcoma as the characteristic zonal ossification pattern is not present
Metabolic/arthritic processes
• Brown tumor of hyperparathyroidism
• Melorheostosis
• Osteonecrosis
• Paget’s disease
• Calcific tendinitis (resorptive phase)
• Subchondral cyst (geode)
6 months after removal of parathyroidadenoma
Brown Tumors in
Hyperparathyroidism
Brown Tumors in
Hyperparathyroidism
• Develop in untreated hyperparathyroidism (10 or 20) • Brownish blood products give rise to its name• 5% of patients with hyperparathyroidism • Well-defined lytic lesions with or without septations and
can expand the bone appearing aggressive• With treatment, e.g. removal of the parathyroid adenoma,
the lesions can become sclerotic• The lack of a change in the appearance of the lesion with
treatment should raise suspicion for an alternative diagnosis
Melorheostosis
• Benign bone dysplasia characterized by sclerotic bone lesions
• Involves bones in sclerotomal distribution
• “dripping candle wax” appearance
• 50% will show signs of the disease by age 20
• Pain, limb deformities related to muscle and tendon shortening, skin disorders, and poor circulation. But mostly asymptomatic
• Can be mistaken for a surface osteosarcoma or osteochondroma
OsteochondromaParosteal Osteosarcoma
Osteonecrosis
• Ischemic necrosis of the bone and marrow
• Causes: trauma, steroids, hemoglobinopathies, alcoholism, pancreatitis, SLE, Gaucher’s, irradiation, Caisson disease
• (1) bone infarcts occur in metaphysis and diaphysis
(2) AVN involves the subchondral bone and that can lead to collapse of the articular surface
• Serpentine double line T2 signal on MRI
Paget’s Disease
Lytic phaseChronic phase
Paget’s Disease • Chronic abnormal bone remodeling leading to osseous expansion
and deformity
• Rare <55 and Chinese
• Linked to paramyxoviruses
• Complications: pain, fractures, hearing loss, increasing head size, renal stones, loose teeth, and high output cardiac failure
<1% malignant transformation to a sarcoma
• Active phase characterized by bone resorption.
– Extends from end of long bone to mid-diaphysis in a “blade of grass” or “flame” pattern
– Tibia is exception, lucent area may be centered in the diaphysis
• Pelvis is the most commonly involved site and often unilateral
Calcific Tendinitis
• Hydroxyapatite deposition disease (HADD)
• Deposition of calcium hydroxyapatite crystals in the tendons
• Most common in the tendons of the rotator cuff and the hip, however, it can involve any tendon
• Acute flare show ill-defined faint calcifications at tendon attachments.
Breast CA MetastasisCalcific Tendinitis
Osteoarthritis
T1
T2 FS
Subchondral Cyst
• Very common• Due to osteoarthritis• Synovium and joint fluid
enters bone via defect in the articular cartilage due to increased joint pressure
• Abut the joint surface, and have a sclerotic margin
Infection
• Brodie’s abscess
Brodie’s abscess (infection)
Osteoid Osteoma
Brodie’s Abscess• Imaging appearance depends on clinical stage
• Acute stage
– Radiographs reveal periostitis, cortical destruction, endosteal scalloping. Soft tissue swelling, abscess, and gas formation
• Subacute or chronic osteomyelitis
– Brodie’s abscess, often in metaphysis of long bones.
– Lucent lesion with surrounding sclerosis
– Sinus tract extending away from the center can help to distinguish a Brodie’s abscess from other lesions (i.e. osteoid osteoma)
Brodie’s abscess
Iatrogenic causes
• Biceps tenodesis
• Bone marrow biopsy
• Particle disease
• Radiation changes
Biceps tenodesis
• The long head of the biceps tendon is cut and reattached to the proximal humeral diaphysis
• Performed for treatment of biceps tendinitis and tear
Bone marrow biopsy
• Bone marrow aspirate commonly attained from the iliac bone from a posterior approach
• Edema in the marrow following bone marrow biopsy should not be mistaken for a focal lesion
Particle disease
• Most common cause of hardware failure
• Polymethylmethacrylate cement, polyethylene, or metal incites a macrophage-mediated granulomatous response stimulating osteoclast activity
• Lucencies surrounding the hardware components
• Unlike mechanical loosening, lytic areas do not follow the outline of the prosthesis
Radiation changes
• In early stage (hours to days), radiation causes vascular congestion, edema, and hypocellularity in the bone marrow. Low signal on T1 and high on T2
• Later (weeks to months) the bone marrow will be replaced with fat and occasionally fibrosis
• Often see line of demarcation from abnormal tissue with normal tissue outside of the irradiated field T1
Radiation changes
Technical artifacts
• Humeral head (internal rotation view)
• Radial tuberosity (lateral view)
• MRI pulsation artifact
• MRI wrap-around (aliasing) artifact
• External objects
These lesions are not real!
External RotationInternal RotationLesion disappears
Humeral head pseudolesion on internal rotation view
• Appears in humeral head on the internal rotation view
• Sharp sclerotic border forms at humeral head/neck junction as the diameter of the bone changes abruptly
• Lesion disappears on the external rotation view
Radial tuberosity pseudolesion on lateral view
Lateral view AP viewLesion disappears
Pulsation Artifact
MRI pulsation artifact
• Ghosting artifact from pulsatile arterial or venous flow can mimic lesions as image data from the vessels are superimposed onto bone or soft tissue
• Exchanging the phase and frequency encoding directions can help to resolve whether or not the lesions are real
MRI wrap-around (aliasing) artifact
Lipoma Sebaceous cyst on the back projecting over arm from wrap-around artifact
External object artifact
Normal fatNo lesion
External object artifact
• Objects lying over or under the patient can mimic a bone lesion
• Especially problematic in acute trauma where studies need to be performed quickly and imaging technique may not be optimal
Bone Tumor Mimickers– Normal variants
• Red marrow• Ward’s triangle in femur• Humeral pseudocyst• Calcaneal pseudotumor (anterior
aspect)
– Congenital anomalies/ developmental
• Synovial herniation pit in proximal femur (Pitt’s pit)
• Supracondylar process• Soleal line on tibia
– Trauma • Subperiosteal hematoma• Stress fracture• Myositis ossificans
– Metabolic/arthritic processes• Brown tumor of
hyperparathyroidism• Melorheostosis• Osteonecrosis• Paget’s disease• Calcific tendinitis (resorptive
phase)• Subchondral cyst (geode)
– Infection• Brodie’s abscess
– Iatrogenic• Biceps tenodesis• Bone marrow biopsy• Particle disease• Radiation changes
– Technical artifacts• Humeral head (internal rotation
view)• Radial tuberosity (lateral view)• MRI pulsation artifact• MRI wrap-around (aliasing) artifact • External objects
Melorheostosis-Cortical thickening-multiple bones in sclerotomal distribution
Case 1
Paget’s Disease
-Cortical and medullary sclerosis and enlargement-Increase activity on bone scan
Case 2
Red Marrow
-T1 signal is hyperintense to muscle
Case 3
Case 4
Brown tumors – hyperparathyroidism
“salt and pepper” skull from bone resorption
Case 4
bony resorption of the middle phalanges
Summary/Pearls• Many lesions can be mistaken for a bone
tumor
• Bone tumor mimickers can be due to many disorders and imaging artifacts
• High index of suspicion and knowledge of the common bone tumor mimickers will prevent misdiagnosis and inappropriate treatment
Suggested Reading
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