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MegaPre™ is the first Precision

Prebiotic™ supplement that can

effectively diversify your gut

microbiome without feeding

potential pathogens.

Aren’t all prebiotics the same?

Prebiotics are essentially dietary fibers that cannot be

digested or absorbed by the human digestive tract but

instead feed the bacteria living in your gut. The problem

is that most prebiotics on the market are not selective.

This means that they can feed both harmful and

beneficial gut bacteria, which can often exacerbate

digestive issues.

MegaPre™ contains medium-chain carbohydrates,

known as oligosaccharides, that cannot be digested by

humans but instead target keystone species known as

secondary degraders.

Primary degraders feed on the bulkier fibers like

cellulose, resistant starches, and inulin and then convert

them into intermediate products like acetate, lactate,

and oligosaccharides that can then feed the

butyrate-producing secondary degraders.1 These

complex fibers are important because they can feed

beneficial bacteria, but they can also be utilized by

harmful bacteria. For this reason, we decided to skip the

first step and provide the gut microbiome with the

intermediate byproducts that it needs to produce

beneficial short-chain fatty acids (SCFAs) like butyrate.

The oligosaccharides used in MegaPre™ have been

clinically shown to significantly increase keystone

species like Akkermansia muciniphila, Faecalibacterium

prausnitzii, and Bifidobacteria - all of which are very

important for healthy metabolism, intestinal barrier

function, and body composition.2-5

• Livaux® FOS increases F. prausnitzii by 100% in 4 weeks6

• B-GOS increases Bifidobacteria by 67% in 1 week7

• PreticX® XOS increases Bifidobacteria by 21% and

significantly increases A. muciniphila in 4 weeks8

MegaPre™ was designed to specifically reinforce these

keystone strains without feeding the dysbiotic flora in

the gut.

Research shows that the ingredients in MegaPre™ can help

support a strong immune system through the production

of short-chain fatty acids (SCFAs), which can subsequently

stimulate intestinal cells to produce a protective

compound known as β-defensin that can help to keep the

gut microbiome in balance.9

One study found that consuming Livaux® gold kiwifruit

concentrate, found in MegaSporeBiotic™, could modulate

the immune system by increasing the production of T-cells

and immunoglobulins, such as IgG, which can help

support a balanced gut microbiome.10 Another study

conducted on the effects of B-GOS on immune function in

elderly adults found that the lactose-derived B-GOS

significantly increased phagocytosis and natural killer cell

activity, two components which are essential for a strong

immune system.11

• Diversify the microbiome

• Support keystone species

• Support immunity

MegaPre + Immunity

Functions

The three fundamental aspects of gut health include: the

microbial population, physical structures, and regulatory

immune function. A healthy gut microbiome is

multi-faceted and relies heavily upon all 3 of these factors,

like a three-legged stool. For this reason, therapies that

only address one of these facets do not typically provide

total restoration of a dysfunctional GI tract. The

Microbiome Labs Total Gut Restoration system was

uniquely designed to target all 3 of these areas, providing

healthcare professionals with highly effective tools in the

battle against chronic disease.

Total Gut Restoration AT A GLANCE

1. Ze X, et al. Ruminococcus bromii is a keystone species for the degradation of resistant starch in the human colon. ISME J. 2012;6(8):1535-1543. 2. Dao MC, et al. Akkermansia muciniphila and improved metabolic health during a dietary intervention in obesity: relationship with gut microbiome richness and ecology. Gut. 2016;65(3):426-436. 3. Chelakkot C, et al. Akkermansia muciniphila-derived extracellular vesicles influence gut permeability through the regulation of tight junctions. Exp Mol Med. 2018;50(2):e450. 4. Cao Y, et al. Association between Faecalibacterium prausnitzii Reduction and Inflammatory Bowel Disease: A Meta-Analysis and Systematic Review of the Literature. Gastroenterol Res Pract. 2014;2014:872725. 5. Hidalgo-Cantabrana C, et al. Bifidobacteria and Their Health-Promoting Effects. Microbiol Spectr. 2017;5(3):10.1128/microbiolspec.BAD-0010-2016. 6. Blatchford P, et al. Consumption of kiwifruit capsules increases Faecalibacterium prausnitzii abundance in functionally constipated individuals: a randomised controlled human trial. J Nutr Sci. 2017; 6:e52. 7. Depeint F, et al. Prebiotic evaluation of a novel galactooligosaccharide mixture produced by the enzymatic activity of Bifidobacterium bifidum NCIMB 41171, in healthy humans: a randomized, double-blind, crossover, placebo-controlled intervention study. Am J Clin Nutr. 2008; 87(3):785-91. 8. Finegold SM, et al. Xylooligosaccharide increases Bifidobacteria but not Lactobacilli in human gut microbiota. Food Funct. 2014; 5(3):436-45 9. Parada Venegas D, et al. Short Chain Fatty Acids (SCFAs)-Mediated Gut Epithelial and Immune Regulation and Its Relevance for Inflammatory Bowel Diseases. Front Immunol. 2019;10:277. 10. Skinner, M. Wellness foods based on the health benefits of fruit: gold kiwifruit for immune support and reducing symptoms of colds and influenza. Journal of Food and Drug Analysis. 2012;20(Suppl 1): 261-264. 11. Vulevic, et al. Modulation of the fecal microfloraprofile and immune function by a novel trans-galactooligosaccharide mixture (B-GOS) in healthy elderly volunteers. Am J Clin Nutr. 2008;88: 1438 – 46.

MegaPre Powder

Dosing: Ages 2+: Start with 1⁄2 scoop daily with or without a meal for 1 week, then increase to 1 scoop daily with or without a meal, or as directed by your healthcare practitioner. Mix powder with 16 oz or more of cold water, or blend into your favorite smoothie. For children under 2 years of age, please consult with your healthcare practitioner.

Supplement Facts

OTHER INGREDIENTS: Organic Natural Mango Flavor, Malic Acid, Citric Acid, Stevia Extract (Reb A), and Monk Fruit Extract 80%.

Serving Size: 5 grams (1 scoop)Servings Per Container: 30Amount Per Serving

CaloriesTotal Carbohydrate Dietary FiberTotal Sugars

Proprietary Functional Fiber Blend Galactooligosaccharides (Bimuno®)

Organic Fructooligosaccharides (Livaux® and ACTAZIN®)

Organic Xylooligosaccharides (PreticX®)

% Daily Value

104 g

1g1g

4 g

1%

4%

Percent Daily Values are based on a 2,000 calorie diet.Daily values not established.

%

Dosing: Ages 2+: Start with 3 capsules daily with or without a meal for one week, then increase to 6 capsules daily with or without a meal, or as directed by your healthcare practitioner. If child cannot swallow capsules, simply open capsules and empty contents into food or drink. For children under 2 years of age, please consult with your healthcare practitioner.

Supplement Facts

OTHER INGREDIENTS: Cellulose, vegetable capsule (cellulose and water).

Serving Size: 6 capsulesServings Per Container: 30Amount Per Serving

Proprietary Functional Fiber Blend Galactooligosaccharides (Bimuno®)

Organic Fructooligosaccharides (Livaux® and ACTAZIN®)

Organic Xylooligosaccharides (PreticX®)

% Daily Value

4 g

Daily values not established.

August 2020

IngredientLivaux®.....................................................ACTAZIN®...............................................Bimuno® GOS ..................................................PreticX® XOS ................................

SourceGold kiwifruit

Green kiwifruitLactose

Non-GMO corn cob

MegaPre™ is part of our Total Gut Restoration

system and serves to REINFORCE the beneficial

changes created by MegaSporeBiotic™ in order to

promote a strong and diverse microbiome.

MegaPre Capsules