lecture+9 physiology

7/24/2019 Lecture+9 physiology

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Lecture 9Mary Ann Price

[email protected] 744A

Ofce Hours M !!"!2# $ 4"%
mailto:[email protected]:[email protected]


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Announcements

Pia&&a is up

'(e test scores are ra) scores out o* !++

,-am )ei(tin / (i(est counts *or more t(an 01!.2%.7%

Problems *rom t(e boo 0not to be raded

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Platelets

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Platelets

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5o nucleus6 but contain mitoc(ondria6

smoot( ,6 and membrane"bound


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Hemos

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Must stop blood 8essels )it(out band )(ile under

3 ma:or steps ;asocontriction

'emporary blocplatelet plu


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Platelet plu *ormation

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Prostacycreleased *intact endpre8ent p*rom spre

blocin p


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Platelet acti8atin *actor 0PA>

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?indin o* platelet inte-posed collaen leadrelease o* serotonin6 APA> *rom ranules

PA> causes acti8ation platelets6 positi8e *ee

PA> also leads to t(roA2 production

erotonin and t(rombare 8asoconstrictors acontribute to platelet

5ABs


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>ibrinoen to >ibrin polymer

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>ibrin and Ebrinolysis

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PA F tissue plasminoen acti8ator


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Anticoaulation

Bn(ibition o* platelet ad(esion

Bn(ibition o* coaulation cascade Heparin and antit(rombin BBB toet(er bloc acti8ated *actors BC

Protein < in(ibits *actors ; and ;BBB

'reatments *or myocardial in*arction6 clottin ris treptoinase and tPA to dissol8e clots toet(er )it( antiplate

0e..6 interin antaonists to pre8ent *urt(er platelet plu and*ormation

Acetylsalicylic acid6 a


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'(e espiratoryystem


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>our *unctions o* respiratorysystems

,-c(ane o* ases bet)een t(e atmosp(ere andblood

Homeostatic reulation o* body pH

Protection *rom in(aled pat(oens and irritatinsubstances

;ocali&ation

'ec(nically6 )eJre talin about e-ternal respiratopposed to cellular respiration

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?ul >lo) o* Air

>lo) taes place *rom (i(er to lo)er pressure A muscular pump creates pressure radients

esistance to air o) is inuenced primarily by tdiameter o* t(e tubes t(rou( )(ic( t(e air is o

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,-ternal esp>our interated p

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tructures in8ol8ed in 8entilatioand as e-c(ane

Air)ays t(at lead *rom outside to e-c(ane sur*lun

'(e e-c(ane sur*ace al8eoli6 a series o*interconnected sacs6 and t(eir associated pulmocapillaries

'(e bones and muscles o* t(e t(ora- and abdomassist in 8entilation

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'(e bones o* spinecae and t(eir assomuscles *orm t(e tcae

'(e diap(ram6 a ds(aped s(eet o* s

muscle6 *orms t(e o* t(e cae

Pleural sacs and pleural uid


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Pleural sacs and pleural uid

'(ora- is a sealed cont)it( 3 sacs 2 pleural s

t(e luns and t(e pericaround t(e (eart

,ac( pleural membranse8eral layers o* elastictissue

'(e t)o layers are (elda t(in layer o* pleural Moist slippery sur*aces t

across eac( ot(er )(en

Holds luns aainst t(e luns are stretc(ed and

inated e8en at rest21


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'(e trac(ea is (eld open


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Air is conditioned in t(e upperair)ays

$armed to body temperature $ater 8apor added to !++K (umidity

>orein material Eltered out

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Mucociliary escalator

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$atery saline layer and


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$atery saline layer and ibrosis

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Al8eoli


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Al8eoli are air Elled clusters at t(e endsbronc(ioles

Primary *unction e-

ases )it( t(e blood ,ac( al8eolus is a s

epit(elium )it( no smuscle

')o cell types / typeal8eolar cells

'ype B is *or as e-cblood

'ype BB is *or sur*act

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Al8eoli


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al8eolar sur*ace area is used *or as e-c(ane# ?lood 8essels Ell +"9+K o* space be27


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pulmonary circulation

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( l i l i


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'(e Pulmonary

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