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Lecture 9Mary Ann Price
[email protected] 744A
Ofce Hours M !!"!2# $ 4"%
mailto:[email protected]:[email protected] -
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Announcements
Pia&&a is up
'(e test scores are ra) scores out o* !++
,-am )ei(tin / (i(est counts *or more t(an 01!.2%.7%
Problems *rom t(e boo 0not to be raded
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Platelets
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Platelets
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5o nucleus6 but contain mitoc(ondria6
smoot( ,6 and membrane"bound
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Hemos
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Must stop blood 8essels )it(out band )(ile under
3 ma:or steps ;asocontriction
'emporary blocplatelet plu
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Platelet plu *ormation
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Prostacycreleased *intact endpre8ent p*rom spre
blocin p
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Platelet acti8atin *actor 0PA>
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?indin o* platelet inte-posed collaen leadrelease o* serotonin6 APA> *rom ranules
PA> causes acti8ation platelets6 positi8e *ee
PA> also leads to t(roA2 production
erotonin and t(rombare 8asoconstrictors acontribute to platelet
5ABs
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>ibrinoen to >ibrin polymer
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>ibrin and Ebrinolysis
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PA F tissue plasminoen acti8ator
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Anticoaulation
Bn(ibition o* platelet ad(esion
Bn(ibition o* coaulation cascade Heparin and antit(rombin BBB toet(er bloc acti8ated *actors BC
Protein < in(ibits *actors ; and ;BBB
'reatments *or myocardial in*arction6 clottin ris treptoinase and tPA to dissol8e clots toet(er )it( antiplate
0e..6 interin antaonists to pre8ent *urt(er platelet plu and*ormation
Acetylsalicylic acid6 a
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'(e espiratoryystem
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>our *unctions o* respiratorysystems
,-c(ane o* ases bet)een t(e atmosp(ere andblood
Homeostatic reulation o* body pH
Protection *rom in(aled pat(oens and irritatinsubstances
;ocali&ation
'ec(nically6 )eJre talin about e-ternal respiratopposed to cellular respiration
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?ul >lo) o* Air
>lo) taes place *rom (i(er to lo)er pressure A muscular pump creates pressure radients
esistance to air o) is inuenced primarily by tdiameter o* t(e tubes t(rou( )(ic( t(e air is o
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,-ternal esp>our interated p
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tructures in8ol8ed in 8entilatioand as e-c(ane
Air)ays t(at lead *rom outside to e-c(ane sur*lun
'(e e-c(ane sur*ace al8eoli6 a series o*interconnected sacs6 and t(eir associated pulmocapillaries
'(e bones and muscles o* t(e t(ora- and abdomassist in 8entilation
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'(e bones o* spinecae and t(eir assomuscles *orm t(e tcae
'(e diap(ram6 a ds(aped s(eet o* s
muscle6 *orms t(e o* t(e cae
Pleural sacs and pleural uid
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Pleural sacs and pleural uid
'(ora- is a sealed cont)it( 3 sacs 2 pleural s
t(e luns and t(e pericaround t(e (eart
,ac( pleural membranse8eral layers o* elastictissue
'(e t)o layers are (elda t(in layer o* pleural Moist slippery sur*aces t
across eac( ot(er )(en
Holds luns aainst t(e luns are stretc(ed and
inated e8en at rest21
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'(e trac(ea is (eld open
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Air is conditioned in t(e upperair)ays
$armed to body temperature $ater 8apor added to !++K (umidity
>orein material Eltered out
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Mucociliary escalator
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$atery saline layer and
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$atery saline layer and ibrosis
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Al8eoli
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Al8eoli are air Elled clusters at t(e endsbronc(ioles
Primary *unction e-
ases )it( t(e blood ,ac( al8eolus is a s
epit(elium )it( no smuscle
')o cell types / typeal8eolar cells
'ype B is *or as e-cblood
'ype BB is *or sur*act
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Al8eoli
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al8eolar sur*ace area is used *or as e-c(ane# ?lood 8essels Ell +"9+K o* space be27
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pulmonary circulation
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( l i l i
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'(e Pulmonary