lecture 06 – intracellular signal receptors lecture 06 – intracellular signal receptors biol...

Lecture 06 – Intracellular Signal Receptors BIOL 5190/6190 Cellular & Molecular Singal Transduction Prepared by Bob Locy Last modiﬁed -13F

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Lecture 06 – Intracellular Signal Receptors

BIOL 5190/6190 Cellular & Molecular Singal TransductionPrepared by Bob Locy

Last modified -13F

Intracellular Signal Receptors

1. Steroid hormone receptors•

2. Other Lipophillic receptors•

3. Heat shock signaling

Page 3: Lecture 06 – Intracellular Signal Receptors Lecture 06 – Intracellular Signal Receptors BIOL 5190/6190 Cellular & Molecular Singal Transduction Prepared

CSB Fig 1:12 Seroid stimuli

Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

Page 4: Lecture 06 – Intracellular Signal Receptors Lecture 06 – Intracellular Signal Receptors BIOL 5190/6190 Cellular & Molecular Singal Transduction Prepared

Androgen receptor signaling pathway

Page 5: Lecture 06 – Intracellular Signal Receptors Lecture 06 – Intracellular Signal Receptors BIOL 5190/6190 Cellular & Molecular Singal Transduction Prepared

Androgen receptor signaling

Page 6: Lecture 06 – Intracellular Signal Receptors Lecture 06 – Intracellular Signal Receptors BIOL 5190/6190 Cellular & Molecular Singal Transduction Prepared

Cortisol Signaling Pathway

Page 7: Lecture 06 – Intracellular Signal Receptors Lecture 06 – Intracellular Signal Receptors BIOL 5190/6190 Cellular & Molecular Singal Transduction Prepared

Estrogen Signaling Pathway

Page 8: Lecture 06 – Intracellular Signal Receptors Lecture 06 – Intracellular Signal Receptors BIOL 5190/6190 Cellular & Molecular Singal Transduction Prepared

Progesterone Signaling Pathway

Page 9: Lecture 06 – Intracellular Signal Receptors Lecture 06 – Intracellular Signal Receptors BIOL 5190/6190 Cellular & Molecular Singal Transduction Prepared

Retinoic Acid Signaling Pathways

Page 10: Lecture 06 – Intracellular Signal Receptors Lecture 06 – Intracellular Signal Receptors BIOL 5190/6190 Cellular & Molecular Singal Transduction Prepared

Vitamin D receptor signaling pathway

Page 11: Lecture 06 – Intracellular Signal Receptors Lecture 06 – Intracellular Signal Receptors BIOL 5190/6190 Cellular & Molecular Singal Transduction Prepared

Heat Shock Factor Cycle of HSP gene activation

Most signal receptors are plasma membrane proteins

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