koop 085 posters raptor ispor belgium v4.0

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Post on 22-Jan-2018




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  1. 1. OBJECTIVES: To conduct an economic evaluation of levofloxacin inhalation solution (LIS) compared to aztreonam lysine inhalation solution (AZLI) in Belgium for the treatment of chronic Pseudomonas aeruginosa lung infection in adult cystic fibrosis (CF) patients. METHODS: A 24-week cycle Markov model was developed based on the approach followed by Tappenden et al.(1) to estimate the expected costs and quality-adjusted life year (QALY) gains over three- and five-years. Utility values were dependent on lung function, exacerbations and having received lung transplantation. Model structure and transitions between the different health states of the model are presented in Figure 1. FEV1: Forced expiratory volume in 1 second Figure 1. Model structure The model simulated the disease progression of CF patients as measured by the decrease in FEV1 percent predicted. Additionally, a possibility of undergoing lung transplant and mortality were integrated in the model. The simulation started on initiation of treatment with either LIS or the comparator (AZLI). At baseline, patients were distributed across 3 levels of severity of FEV1: FEV170%, FEV1 40-69% and FEV1