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ISNI 201412th International Congress of Neuroimmunology

9-13 November 2014 | Mainz, Germany

ISNIInternational Societyof Neuroimmunology

SCIENTIFIC PROGRAM

2 COMMITTEE

12th International Congress of Neuroimmunology | 9-13 November 2014

2

ISNI EXECUTIVE

PresidentGianvito Martino (Italy)

Vice-PresidentV. Wee Yong (Canada)

Secretary / TreasurerRoberto Furlan (Italy)

INTERNATIONAL ADVISORY BOARD

S. Amor (Leiden, the Netherlands)D. Baker (London, UK)A. Bar-Or (Montreal, Canada)B. Becher (Zurich, Switzerland)M. Carson (Del Mar, USA)A. Coles (Cambridge, UK)R. Gold (Bochum, Germany)B. Hemmer (Munich, Germany)R. Hintzen (Rotterdam, the Netherlands)L. Probert (Athens, Greece)M. Racke (Powell, USA)M. Schwartz (Rehovot, Israel)L. Steinman (Stanford, USA)P. Villoslada (Barcelona, Spain)A. Waisman (Mainz, Germany)T. Yamamura (Tokyo, Japan)S. Zamvil (San Francisco, USA)F. Zipp (Mainz, Germany)

HONORARY OFFICERS

J. Antel (Montreal Canada)C. Raine (New York, USA)A. Vincent (Oxford, UK)H. Wekerle (Martinsried, Germany)C. Whitacre (Columbus, USA)T. Owens (Odense, Denmark)T. Olsson (Stockholm, Sweden)

CONGRESS ORGANIZERS

Congress ChairsAri Waisman (Mainz, Germany)Frauke Zipp (Mainz, Germany) Burkhard Becher (Zurich, Switzerland)Britta Engelhardt (Bern, Switzerland)Ralf Gold (Bochum, Germany)Hans-Peter Hartung (Duesseldorf, Germany)Bernahrd Hemmer (Munich, Germany)Reinhard Hohlfeld (Munich, Germany)Ludwig Kappos (Basel, Switzerland)Hans Lassmann (Vienna Austria)Marco Prinz (Freiburg, Germany)Hartmut Wekerle (Martinsried, Germany)Heinz Wiendl (Munster, Germany)

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On behalf of the International Society of Neuroimmunology (ISNI) and the Rhine Main Neuroscience Network (rmn2), we are pleased to invite you to participate in the Twelfth ISNI Congress, which will be held in the Rheingoldhalle Mainz, Germany, from November 9th - 13th, 2014.

There are exciting developments in the field of Neuroimmunology affecting our understanding of neuroimmune diseases, the development of new immunotherapies, and new technology for research.

The Organizing Committee, on behalf of the ISNI, is preparing an exciting program that will inform participants on the latest developments in the field. The program will include plenary sessions, focused symposia, and workshops. Plenty of time is devoted to poster presentations. We want to see you there!

Mainz is an old Roman city and a cultural center located only 20 minutes from the international airport of Frankfurt. The city is rich in history and is a touristic attraction. Mainz is the birthplace of Johannes Gutenberg and home for the museum in his name that describes the invention of the print. The University of Mainz, the host of the meeting also bears the name of Gutenberg and is one of the largest Universities in Germany. Museums, places to visit and restaurants in the city will make this event a wonderful experience.

We look forward to seeing you in Mainz as part of the rmn2!

Frauke Zipp Ari Waisman

Conference ChairsUniversity Medical Center of the Johannes Gutenberg University of Mainz

ISNIInternational Societyof Neuroimmunology

4 GENERAL INFORMATION


4

General information

Dates14th ESNI pre-congress CourseEuropean School of Neuroimmunology Sunday, November 9, 2014

12th ISNI CongressInternational Society of NeuroimmunologyMonday, November 10 to Thursday November 13, 2014

Congress venueRheingoldhallemainzplus CITYMARKETING GmbHRheinstrasse 66D-55116 Mainz, Germanywww.ccmmainz.de/rheingoldhalle.html

Registration deskOpening hours are as follows:Saturday November 8 16.00 - 19.30Sunday November 9 07.00 - 18.00Monday November 10 07.00 - 18.00Tuesday November 11 07.30 - 18.00Wednesday November 12 07.30 - 18.00Thursday November 13 07.30 - 16.00

Participant’s fee includes•Participant’s badge and congress material•Access to scientific sessions and exhibition•Abstract book•Certificate of attendance•CME Accreditation

BadgeUpon registration you will receive your congress kit with your name badge. You are kindly requested to wear your badge during all congress sessions and events. In case you lose your badge, please ask for a duplicate at the congress secretariat desk.

Certificate of attendanceCertificates of attendance will be sent to all partici-pants by e-mail upon request after the congress end.

Exhibition areaThe exhibition area is in the Rhinefoyer.Opening hours are as follows:Monday November 10 07:00 - 18:00 Tuesday November 11 07:00 - 18:00Wednesday November 12 07:00 - 18:00 Thursday November 13 07:00 - 15:30

Pre-Congress Teaching CourseThe 14th ESNI Course will take place in the Kongress Saal between 9:15am and 6:00pm on Sunday, No-vember 09, 2014. Delegates attending the course should register at the registration desk between 4:00pm and 8:00pm on Saturday November 8. Only the registered Students/Post.docs or the delegates who confirmed their participation in the 14th ESNI Course when they registered on-line are allowed.

Plenary LecturesThere will be four plenary lectures from Monday to Thursday.Lectures will take place in the Kongress Saal of the Rheingoldhalle.

Plenary SymposiaThere will be four plenary symposia in the morning from Monday to Thursday.All plenary sessions will take place in the Kongress Saal.

Concurrent SymposiaThere will be twelve concurrent symposia. All con-current sessions will take place in Room A (Kon-gress Saal), Room B (Gutenbergsaal 1) and Room C (Gutenbergsaal 2) of the Rheingoldhalle.

5

Scientific Program

5

Oral SessionsOral communications are allotted about 15 minutes for the presentation. Authors are kindly requested to respect their presentation time. Power Point video projection will be available in all rooms for the pre-sentations, authors must upload their presentation at the Speakers’ Ready Room located in the Rhine-foyer, no later than 9:00am on the assigned date of presentation, or beforehand.

Poster SessionsPosters will be on display on Monday, Tuesday and Wednesday between 9:00am and 5:30pm in the Rhinefoyer.You can place your poster on the assigned board be-tween 7:00pm of the previous day and 9:00am of the assigned date. Poster should be removed by au-thors between 5:30pm and 7:00pm on the same day of the assigned session. The Congress Secretariat will not be responsible for posters left behind. Poster size should be maximum 70cm wide and 1m high and will be displayed as a portrait. The position of each poster will be marked by the poster number and title, please place your poster on the assigned board.Authors must be present during the assigned poster session.

Underneath please find the poster sessions schedule

Monday, November 10PS 1 B cells and antibodiesPS 2 BiomarkersPS 3 Blood brain barrierPS 4 Clinical researchPS 5 Innate immune systemPS 6 Models of diseasePS 7 OmicsPS 8 PathologyPS 9 Psychoimmunomodulation

Tuesday, November 11PS 10 Immunological mechanismsPS 11 GeneticsPS 12 miRNAPS 13 Neuroinflammation

Wednesday, November 12PS 14 Brain tumors and paraneoplasticPS 15 InfectionsPS 16 Mechanisms of CNS diseasePS 17 NeurodegenerationPS 18 RepairPS 19 Stem cellsPS 20 T-cellsPS 21 Therapies

LanguageEnglish is the official language of the congress. No simultaneous translation will be provided.

SessionsPlease make sure to be in the session hall on time as all sessions will begin and end as according to the schedule.

Lunch breaksParticipants that have ordered their lunch will receive lunch coupons from Monday to Thursday. Participants that also ordered lunch for the ESNI Course will also receive a coupon for Sunday. Please show your lunch coupons to receive your lunch which will be distributed in the designed areas according to the schedule.

CME creditsThe 12th ISNI congress (International Congress of Neu-roimmunology) and the 14th Esni Course (European School of Neuroimmunology) have been accredited by the European Accreditation Council for Continuing Medical Education (EACCME) for 28 credits. That is the maximum possible number of credits we could get. This amazing result has been obtained thanks to the high level of the scientific program and the number of learning hours.

The EACCME is an institution of the European Union of Medical Specialists (UEMS), www.uems.net. Each medical specialist should claim only those hours of credits that he/she actually spent in the educational activity. EACCME credits are recognized by the American Med-

6 GENERAL INFORMATION


ical Association towards the Physician’s Recognition Award (PRA). To convert EACCME credit to AMA PRA category 1 credit, please contact the AMA. Other bi-lateral agreements may exist between AMA ACCME and your local CME authority.

Disabled personsThe Rheingoldhalle is equipped with facilities for diabled persons. However, if you have any special needs or disabilities, please let the organizing secre-tariat know when registering for the congress.

InsuranceThe organizers will not accept liability for individual medical, travel or personal insurance. It is highly rec-ommended that all participants carry proper health and travel insurance.

Smoking policySmoking is forbidden at any time in the whole Con-gress Venue. Your compliance is appreciated.

Mobile phonesMobile phones must be switched off while attending a session.

Speakers’ ready roomSpeakers’ ready room is located in the Rhinefoyer and operates during the congress hours. See opening hours above.

All rooms are equipped as followAll invited speakers and presenting authors of ac-cepted abstracts as oral presentation are kindly re-quested to visit the Speaker’s ready room at least the day before their presentation time.Speakers should clearly identify themselves and specify the room, date and time of presentation as indicated in the scientific program.During the visit to the speakers’ ready room a tech-nician will load your presentation on the congress computers, run thourgh it and check it. Your pre-sentation will be sent form the central server to the room where you will give your talk. Congress staff will be available in the session rooms for assistance.

EXHIBITORS

•Merck Serono GmbH•BIO-SYS GmbH•Genzyme Europe B.V•NanoString Technologies

NanoString Technologies provides life science tools for translational research and molecular di-agnostic products. The company’s nCounter® Anal-ysis System, which has been employed in basic and translational research and cited in 500 peer review publications, has also now been applied to diagnostic use with the nCounter Dx Analysis Sys-tem. The nCounter-based Prosigna™ Breast Cancer Prognostic Gene Signature Assay is marketed for use on the nCounter Dx Analysis System which is FDA 510(k) cleared.

•Bio-Rad Abd Serotec•Sony Europe Ltd.•Miltenyi Biotec GmbH• Jackson ImmunoResearch Europe Ltd•BioLegend UK Ltd•R&D Systems GmbH•eBioscience•Euroimmun AG

7

Scientific Program

SPEAKERS & CHAIRS

Amparo Acker-Palmer PhDGoethe University Frankfurt, Institute of Cell Biology and Neuroscience, Frankfurt, Germany

Orhan Aktas MDDepartment of Neurology, Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Germany

Francesca Aloisi PhDDepartment of Cell Biology and Neuroscience, Istituto Superiore di Sanità, Rome, Italy

Sandra Amor BSc, PhDPathology Department, VU Medical Center, Amsterdam, the Netherlands

Jack Antel MDDepartment of Neurology, McGill University, Montréal, Canada

Carlo Avolio MDDept. of Medical and Surgical Sciences, University of Foggia, Foggia, Italy

David Baker MDCenter for Neuroscience and Trauma, Blizard Institute of Cell and Molecular Science, Barts & the London School of Medicine, London, UK

Sergio Baranzini PhDHeidrich Family and Friends, Department of Neurology, University of California, San Francisco, US

Amit Bar-Or MD FRCPCNeuroimmunology Unit, Montréal Neurological Institute, McGill University, Montréal, Canada

Luca Battistini MD, PhDNeuroimmunology Unit, Santa Lucia Foundation, Rome, Italy

Burkhard Becher PhDUniversity of Zürich, Institute of Experimental Immunology, Zürich, Switzerland

Ingo Bechmann MDInstitute of Anatomy, University of Leipzig, Leipzig, Germany

Carsten Berndt PhDDepartment of Neurology Medical Faculty Heinrich-Heine University Life Science CenterDüsseldorf, Germany

Wolfgang Brück MDInstitut für Neuropathologie, Universitätsmedizin Göttingen, Georg-August-Universität, Göttingen, Germany

Julia BruttgerInstitute for Molecular MedicineUniversity Medical Center of the Johannes Gutenberg-University of Mainz, Germany

Monica Carson PhDUCRiverside School of Medicine, Riverside, US

Diego Centonze MDMultiple Sclerosis, Clinical & Research, Clinical & Research Center Department of Systems Medicine, Tor Vergata University, Rome, ItalyManuel Comabella MDNeurogenomics Division, Vall d’Hebron University Hospital , Barcelona, Spain

Alastair Compston MDDepartment of Clinical Neurosciences, University Neurology Unit, Cambridge Biomedical Campus, Cambridge, UK

Anne Cross MDDept. of Neurology (McMillan 310), Washington University, School of Medicine, St. Louis, US

Josep Dalmau MDNeurology, Hospital Clínic, University of Barcelona, Barcelona, Spain, University of Pennsylvania, Philadelphia, US

Robert Dantzer DVM, PhDDepartment of Symptom Research, Division of Internal Medicine, Houston, US

Helga de Vries PhDBlood-Brain Barrier Research Group, Dept. of Molecular and Cell Biology and Immunology, VU University Medical Center, Amsterdam, the Netherlands

Suhayl Dhib-Jalbut MDPresident-ACTRIMS, Department of Neurology, Rutgers-Robert Wood Johnson Medical School, New Brunswick, US

Ricarda Diem MDAbteilung für Neuroonkologie, Universitätsklinikum Heidelberg, INF 400, Heidelberg, Germany

Ivan Dikic PhDInstitute of Biochemistry II, Goethe University School of Medicine, Frankfürt, Germany

Britta Engelhardt PhDUniversity of Bern, Theodor Kocher Institute, Bern, Switzerland

Bente Finsen DMScDepartment of Neurobiology, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark

Alexander Flügel PhDInstitute for Multiple Sclerosis Research, Dept. of Neuroimmunology, University Medical Center Göttingen, Göttingen, Germany

8 SPEAKERS & CHAIRS


Lars Fugger MD, PhDNuffield Dept. of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, UK

Roberto Furlan MD, PhDClinical Neuroimmunology Unit, Institute of Experimental Neurology, INSpe Division of Neuroscience, San Raffaele Hospital, Milan, Italy

Ralf Gold MDDepartment of Neurology, St. Josef-Hospital, Ruhr University, Bochum, Germany

Joan Goverman PhDDept. Immunology, University of Washington, Seattle, US

Melanie Greter PhDUniversity of Zürich, Institute of Experimental Immunology, Zürich, Switzerland

David Hafler MDDepartment of Neurology, Yale School of Medicine, New Haven, US

May Han MDDepartment of Neurology and Neurological Sciences, Multiple Sclerosis Center, Stanford Hospital and Clinics, Stanford, US

Hanne Harbo MD, PhDDepartment of Neurology, Oslo University Hospital and University of Oslo, Oslo, Norway

Hans-Peter Hartung MD, FRCPDepartment of Neurology, Heinrich-Heine-University, Düsseldorf, Germany

Bernhard Hemmer MDNeurologischen Klinik und Poliklinik 1, Prodekan der Fakultät für Medizin der Technische Universität München, Klinikum rechts der Isar, München, Germany

Michael Heneka MDDepartment of Neurology, Clinical Neuroscience Unit, University of Bonn, Bonn, Germany

Frank Heppner MDDepartment of Neuropathology, Charité - Universitätsmedizin Berlin, Berlin, Germany

Jan Hillert MD, PhDDepartment of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden

Rogier Hintzen MD, PhDDepartment of Neurology, Erasmus University Medical Center, Rotterdam, the Netherlands

Reinhard Hohlfeld MDInstitute of Clinical Neuroimmunology, Klinikum der LMU München, Campus Grosshadern, München, Germany

Steffen Jung PhDWeizmann Institute of Science, Department of Immunology, Rehovot, Israel

Johanna KaplanNeuroimmunology ResearchGenzyme, a Sanofi company, Framingham, MA, United States

Ludwig Kappos MDUniversity Hospital Basel, Neurology and Department of Biomedicine, Basel, Switzerland

Dimitrios Karussis MDDepartment of Neurology, Hadassah Medical Organization, Hadassah, Jerusalem, Israel

Lloyd Kasper MDGeisel School of Medicine, Dartmouth College, Hanover, US

Martin Kerschensteiner PhDInstitute of Clinical Neuroimmunology, Medical Center of the University of Munich, München, Germany

Samia Khoury MDAbu Haidar Neuroscience Institute, Clinical and Translational Research, Multiple Sclerosis Center, American University of Beirut, Jack, Sadie and David Breakstone, Harvard Medical School, Boston, Beirut, Lebanon

Bernd Kieseier MDDepartment of Neurology, Heinrich-Heine-University, Düsseldorf, Germany

Jonathan Kipnis PhDDepartment of Neuroscience, Center for Brain Immunology and Glia (BIG), University of Virginia, Charlottesville, US

Thomas Korn MDTechnische Universität München, Klinikum rechts der Isar, Experimental Neuroimmunology Group, München, Germany

Vijay Kuchroo DVM, PhDCenter for Neurologic Diseases, Brigham and Women’s Hospital and, Harvard Medical School, Boston, US

Jon D. Laman, PhDDept. Immunology, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, the Netherlands

Antonio Lanzavecchia MDHuman Immunology ETH Zürich, Institute for Research in Biomedicine, Zürich, Switzerland

Hans Lassmann MDHead of Department of Neuroimmunology, Medical University of Vienna, Center for Brain Research, Vienna, Austria

9

Scientific Program

Roland Liblau MD, PhDCentre de Physiopathologie Toulouse Purpan (CPTP), INSERM UMR1043 - CNRS UMR5282, Université Toulouse III, Toulouse, France

Catherine Lubetzki MD, PhDUniversity Pierre and Marie Curie (UPMC), Brain and Spinal Cord Institute (ICM), Salpetriere Hopsital, Paris, France

Burkhard Ludewig DVMInstitute of Immunobiology, Medical Research Center, Kantonsspital St. Gallen, St. Gallen, Switzerland

Gianvito Martino MDDivision of Neuroscience, San Raffaele Hospital, Milan, ItalyEdgar Meinl MDInstitut Für Klinische Neuroimmunologie, Klinikum der Ludwig-Maximilians-Universität München, München, Germany

Doron Merkler MDDepartment of Pathology and Immunology, University of Geneva, Geneva, Switzerland

Sven G. Meuth MD, PhDUniversity Hospital Münster, Department of Neurology and Institute of Physiology I, Neuropathophysiology, Albert-Schweitzer Campus 1, Münster, Germany

Emmanuel Mignot MD, PhDCraig Reynolds, Center for Sleep Sciences and Medicine, Stanford University, Stanford, US

Ariel Miller MD, PhDMultiple Sclerosis and Brain Research Center, Department of Neurology, Carmel Medical Center, Pharmacogenetics and Personalized Medicine Center, Rappaport Faculty of Medicine and Research Institute, Technion-Israel, Institute of Technology, Haifa, Israel

Stephen Miller PhDJudy Gugenheim, Interdepartmental Immunobiology Center, Department of Microbiology-Immunology, Northwestern University Medical School, Chicago, US

Marcin Mycko MD, PhDDepartment of Neurology, Laboratory of Neuroimmunology, Medical University of Lodz, Lodz, Poland

Klaus-Armin Nave PhDMax Planck Institute for Experimental Medicine, Dept. of Neurogenetics, Göttingen, Germany

Tomas Olsson MD, PhDDepartment of Clinical Neurosciences, Neuroimmunology Unit, Center for Molecular Medicine, Karolinska Hospital Stockholm, Sweden

Trevor Owens PhDInstitute of Molecular Medicine, University of Southern Denmark, Odense, Denmark

Nikolaos A. Patsopoulos MD, PhDDepartment of Neurology, Division of Genetics, Department of Medicine, Brigham & Women’s Hospital, Harvard Medical School, Broad Institute, Boston/Cambridge, MA, USA

Michael Platten MD,CCU Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center and, Department of Neurooncology, University Hospital Heidelberg National Center for Tumor Diseases, Heidelberg, Germany

Alexandre Prat MD, PhD, FRCPcDepartment of Neuroscience, Université de Montréal, Montréal, CanadaMarco Prinz MDUniversity Medical Center Freiburg, Insitute of Neuropathology, Freibrug, Germany

Francisco Quintana PhDCenter for Neurologic Diseases, Brigham & Women’s Hospital, Harvard Medical School, Boston, US

Michael K. Racke MDthe Helen C. Kurtz Chair in Neurology, Department of Neurology, Wexner Medical Center at the Ohio State University, Columbus, US

Federica Sallusto PhDInstitute for Research in Biomedicine, Università della Svizzera Italiana, Bellinzona, Switzerland

Hansjorg Schild PhDInstitute for Immunology, University Medical Center Mainz, Mainz, Germany

Detlef Schuppan MD, PhDInstitute of Translational Immunology, University Medical Center of the Johannes Gutenberg University Mainz, Harvard Medical School, Celiac and Small Intestinal Disease Center, Mainz, Germany

Michal Schwartz MD, PhDThe Maurice and Ilse Katz, The Department of Neurobiology, The Weizmann Institute of Science, Rehovot, Israel

Benjamin Segal MDHoltom-Garrett Program in Neuroimmunology and Multiple Sclerosis Center, Department of Neurology, University of Michigan, Ann Arbor, US

Krzysztof Selmaj MD, PhDDepartment of Neurology, Medical University of Lodz, Lodz, Poland

Volker Siffrin MDUniversitätsmedizin der Johannes Gutenberg-Universität Mainz, Klinik und Poliklinik für Neurologie, Forschungszentrum Translationale Neurowissenschaften (FTN), Forschungszentrum Immunologie (FZI), Rhein-Main-Neuronetzwerk (rmn2), Mainz, Germany

10 SPEAKERS & CHAIRS


Lydia Sorokin MDInstitute of Phyisological Chemistry and Pathobiochemistry, University of Münster, Münster, Germany

Tim Sparwasser MDInstiut für Infektionsimmunologie, TWINCORE - Zentrum f. Experimentelle und, Klinische Infektionsforschung GmbH, Hannover, GermanyChristine Stadelmann-NesslerInstitute for Neuropathology, University Medical Center, Göttingen, Germany

Bruno Stankoff MD, PhDUniversity Pierre and Marie Curie, UPMC Paris, ICM Institut du Cerveau et de la Moelle, Hopital Pitié Salpêtrière and Neurology Department, Hopital Tenon HUEP, APHP, Paris, France

Pavel Stourac MD, PhDDepartment of Neurology, University Hospital, Masaryk University, Brno, Czech Republic

Olaf Stuve MD, PhDNeurology Section, VA North Texas Health Care System, Medical Service, Dallas VA Medical Center, Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center at Dallas, Dallas, USA

Bert ‘t Hart PhDChairman Department of Immunobiology, Biomedical Primate Research Centre, Rijswijk, the Netherlands

Antonio Uccelli MDDepartment of Neurology, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, Genoa, Italy

Annamaria Vezzani PhDLaboratory Experimental Neurology, Dept. of Neuroscience, Mario Negri Institute for Pharmacological Research, Milan, Italy

Pablo Villoslada MD, PhDCenter of Neuroimmunology, Institut Biomedical Research August Pi Sunyer (IDIBAPS), Hospital Clinic of Barcelona, Barcelona, Spain

Angela Vincent MBBSNuffield Department of Clinical Neurosciences, Oxford University Hospital, Oxford, UK

Ari Waisman PhDUniversity Medical Center of the Johannes Gutenberg University, Institute for Molecular Medicine, Mainz, Germany

Howard Weiner MDHarvard Medical School, Brigham & Women’s Hospital, Boston, US

Hartmut Wekerle MDMax Planck Institute of Neurobiology, Emeritus Research Group - Neuroimmunology; Hertie Senior Professorship, Martinsried, Germany

Michael Weller MDDepartment of Neurology, University Hospital Zürich, Zürich, Switzerland

Wolfgang Wick MDAbteilung Neuroonkologie, Neurologische Klinik und Nationales Tumorzentrum, Universitätsklinik Heidelberg, Heidelberg, Germany

Heinz Wiendl MDDepartment of Neurology, University of Münster, Münster, Germany

Hugh Willison MBChB, PhDGlasgow Biomedical Research Centre, Glasgow, UK

Takashi Yamamura MD, PhDDepartment of Immunology, National Institute of Neuroscience, NCNP, Tokyo, Japan

V.Wee Yong PhDUniversity of Calgary, Faculty of Medicine, Calgary, Canada

Akihiko Yoshimura PhDDepartment of Microbiology and Immunology, Keio University School of Medicine, Tokyo, Japan

Scott Zamvil MD, PhDProgram in Immunology, University of California, San Francisco, US

Frauke Zipp MDUniversity Medical Center of the Johannes Gutenberg University, Department of Neurology, Mainz, Germay

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Scientific Program

MORNING SESSION 09:15 - 13:00 PLENARY ROOM (KONGRESS SAAL)

Chair: Gianvito Martino

09:15 INTRODUCTION TO THE COURSE Gianvito Martino

09:30 LYMPHOCYTE TRAFFICKING IN THE CNS Britta Engelhardt

10:15 NEUROIMMUNOGENETICS Tomas Olsson

11:00 Coffee break

11:30 REGULATORY T CELLS: WHERE WE ARE IN NEUROIMMUNOLOGICAL DISORDERS Luca Battistini

12:15 MICROGLIA: WHERE THEY COME FROM? Melanie Greter

LUNCH BREAK 13:00 - 14:30 RHEINFOYER

AFTERNOON SESSION 14:30 - 18:00 PLENARY ROOM (KONGRESS SAAL)

Chair: Gianvito Martino

14:30 INFLAMMATION AND SYNAPTIC PLASTICITY: A NEW EMERGING CONCEPT IN NEUROPROTECTION Diego Centonze

15:15 ION CHANNEL DISORDERS: FROM TARGET IDENTIFICATION TO THERAPIES Josep Dalmau

16:00 Coffee break

16:30 NEUROIMMUNOMODULATION: NEW DRUGS OR REPOSITIONING OF OLD DRUGS? Samia J. Khoury

17:15 CELL BASED THERAPIES IN NEUROIMMUNOLOGICAL DISORDERS: FROM BLOOD TO BRAIN Antonio Uccelli

DAY 1 Sunday | November 9th 2014

12 Day 2 | Monday - November 10th


WELCOME ADDRESS 08:00 - 08:15 PLENARY ROOM (KONGRESS SAAL)

MICROGLIA AND MICROBIOTA 08:15 - 09:30 PLENARY ROOM (KONGRESS SAAL)

Chairs: Alexandre Prat, Ralph Gold

08:15 NATURE PLUS NURTURE: THE INTESTINAL IGNITIO OF DEMYELINATING AUTOIMMUNE DIEASE Hartmut Wekerle

08:53 PERIPHERAL AND BRAIN-RESIDENT IMMUNE CELLS SUPPORT BRAIN FUNCTION IN HEALTH AND DISEASE Jonathan Kipnis

COFFEE BREAK 09:30 - 10:00 POSTERHALL (RHEINFOYER)

EMERGING PSYCHIATRIC-IMMUNOLOGICAL DISORDER 10:00 - 11:45 ROOM A (KONGRESS SAAL)

Chairs: Bernhard Hemmer, Krzysztof Selmaj 10:00 AUTOIMMUNE BASIS OF NARCOLEPSY Emmanuel Mignot

10:23 INFLAMMATION-INDUCED DEPRESSION. EVIDENCE AND MECHANISMS Robert Dantzer

10:45 MECHANISMS OF LESION DEVELOPMENT IN MULTIPLE SCLEROSIS FROM EARLY TO PROGRESSIVE DISEASE STAGES Wolfgang Brück

11:08 Roberto Furlan

11:30 365 - GENETIC STUDY OF PANDEMRIX-ASSOCIATED NARCOLEPSY Izaura Lima Bomfim (1) - Katarina Fink (1) - Favelle Lamb (2) - Niklas Darin (3) - Attila Szakacs (3) - Tove Hallböök (3) - Fredrik Piehl (1) - Lisen Arnheim Dahlström (2) - Ingrid Kockum (1) - Tomas Olsson (1) Department Of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden (1) - Department Of Epidemiology And Biostatistics, Karolinska Institutet, Stockholm, Sweden (2) - Department Of Children, County Hospital, Halmstad, Sweden (3)

GENOTYPE/PHENOTYPE 10:00 - 11:45 ROOM B (GUTENBERGSAAL 1)

Chairs: David Baker, Tim Sparwasser

DAY 2 Monday | November 10th 2014

13

Scientific Program

10:00 RISK GENES, LIFESTYLE/ENVIRONMENTAL FACTORS AND THEIR INTERACTIONS IN MULTIPLE SCLEROSIS Tomas Olsson

10:23 REGULATION OF CNS INFLAMMATION Francisco J. Quintana

10:45 THE DRUGGABLE SPACE OF NEUROLOGIC DISEASES GUIDED BY GENETICS Nikolaos Patsopoulos

11:08 FROM GENOTYPES TO PHENOTYPES IN MULTIPLE SCLEROSIS Hanne Flinstad Harbo

11:30 89 - ROLE OF IMMUNE GENE VARIANTS IN MULTIPLE SCLEROSIS SUSCEPTIBILITY AND SEVERITY: GENETIC BURDEN CONSEQUENCES ON IMMUNE CELL FUNCTIONALITY Mohamed El Behi - Vincent Damotte - Lena Guillot-nöel - Violetta Zujovic - Isabelle Rebeix - Bertrand Fontaine Brain And Spine Institute, Pitié Salpétrière Hospital- Inserm U1127-pierre Et Marie Curie University, Paris, France

BLOOD BRAIN BARRIER 10:00 - 11:45 ROOM C (GUTENBERGSAAL 2)

Chairs: Olaf Stuve, Hansjorg Schild

10:00 IMMUNE CELL MIGRATION ACROSS THE DIFFERENT BRAIN BARRIERS: IMPLICATIONS FOR MULTIPLE SCLEROSIS LESION FORMATION. Elga De Vries

10:23 THE ROLE OF VASCULAR BASEMENT MEMBRANES AND MATRIX METALLPROTEINASES (MMPS) IN LEUKOCYTE MIGRATION INTO THE BRAIN Lydia Sorokin

10:45 ADHESION MOLECULES REGULATING LESION FORMATION IN MS Alexandre Prat

11:08 HOW BRAIN BARRIERS CONTROL IMMUNE CELL ENTRY INTO THE CNS Britta Engelhardt

11:30 432 - NOTCH RECEPTORS AND LIGANDS MEDIATE BARRIER FUNCTION IN BRAIN ENDOTHELIAL CELLS Melissa Lopes Pinheiro (1) - Mark Mizee (1) - Bert Van Het Hof (1) - Susanne Van Der Pol (1) Dirk Geerts (2) - Arie Reijerkerk (1) - Wendy Unger (1) - Helga De Vries (1) Vumc, Vu University Medical Center, Amsterdam, Netherlands (1) - Erasmus University Medical Center, Erasmus University Medical Center, Rotterdam, Netherlands (2)

INDUSTRY SPONSORED: INFLAMMATION AND DEGENERATION IN MS: HOW TO UNRAVEL THE TANGLE? 12:00 - 13:00 PLENARY ROOM (KONGRESS SAAL)

Chair: Reinhard Hohlfeld

12:00 INFLAMMATORY MECHANISMS OF AXONAL INJURY Martin Kerschensteiner 12:30 IMAGING OF AND THERAPEUTIC STRATEGIES FOR PREVENTING NEURODEGENERATION Bruno Stankoff



THE DALE MCFARLIN LECTURE 13:00 - 13:45 PLENARY ROOM (KONGRESS SAAL)

Chair: Michael Racke

13:00 THE PATHOPHYSIOLOGY OF MULTIPLE SCLEROSIS David Hafler

CRC 128 SPONSORED: NEUROINFLAMMATION 13:45 - 15:15 ROOM A (KONGRESS SAAL)

Chair: Sven Meuth

13:45 442 - GLUTAMATERGIC TRANSMISSION IS ENHANCED IN THE AMYGDALA IN EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS Shaona Acharjee - Quentin Pittman Hotchkiss Brain Institute, University Of Calgary, Calgary, Canada

14:03 92 - ENHANCED NETWORK ACTIVITY DESPITE CLINICAL RECOVERY IN EXPERIMENTAL NEUROINFLAMMATION USING TWO-PHOTON CALCIUM IMAGING Erik Ellwardt (1) - Gautam Kumar Pramanik (2) - Eduardo Rosales Jubal (2) - Dirk Luchtman (1) Zeke Barger (2) - Esther Witsch (1) - Frauke Zipp (1) - Albrecht Stroh (2) Focus Program Translational Neurosciences (ftn), Rhine Main Neuroscience Network (rmn2), Department Of Neurology, University Medical Center Of The Johannes-gutenberg University Mainz, Mainz, Germany (1) - Focus Program Translational Neuroscience (ftn), Rhine Main Neuroscience Network (rmn2), Institute Of Microscopy, Anatomy And Neurobiology, Johannes Gutenberg-university Mainz, Mainz, Germany (2)

14:21 491 - TRANSGENIC MICE WITH ASTROCYTE-TARGETED IL-10 PRODUCTION IN THE CNS PRESENTED A SPECIFIC PHENOTYPE OF MICROGLIA THAT CORRELATES WITH CHANGES IN THE HIPPOCAMPAL NEURONAL FUNCTION Beatriz Almolda (1) - Carmen De Labra (1) - Iliana Barrera (1) - Agnès Gruart (2) - Jose Maria Delgado-garcia (2) - Markus Hofer (3) - Juan Hidalgo (1) - Iain L. Campbell (3) - Berta González (1) Bernardo Castellano (1) Dept. Cell Biology, Physiology And Immunology. Institute Of Neurosciences., Autonomous University Of Barcelona, Barcelona, Spain (1) - Division Of Neurosciences, Pablo De Olavide University, Sevilla, Spain (2) School Of Molecular Bioscience, University Of Sydney, Sydney, Australia (3)

14:39 319 - ANTI-TNFR1 TARGETING IN HUMANIZED MICE AMELIORATES DISEASE IN A MODEL OF MULTIPLE SCLEROSIS Sarah K. Williams (1) - Olaf Maier (2) - Roman Fischer (2) - Richard Fairless (1) - Patricia C. Schmitt (1) Uli Eisel (3) - Roland Kontermann (2) - Andreas Herrmann (4) - Eric Guenzi (4) - Ricarda Diem (1) Klaus Pfizenmaier (2) Department Of Neuro-oncology, University Of Heidelberg, Heidelberg, Germany (1) - Institute Of Cell Biology And Immunology, University Of Stuttgart, Stuttgart, Germany (2) - Department Of Molecular Neurobiology, University Of Groningen, Groningen, Netherlands (3) - Baliopharm, Ag, Basel, Switzerland (4)

14:57 604 - SOURCES AND FUNCTIONAL SIGNIFICANCE OF IL-6 IN SHAPING AUTOREACTIVE T CELL RESPONSES IN THE PERIPHERAL IMMUNE COMPARTMENT AND THE CNS Sylvia Heink (1) - Franziska Petermann (1) - Christina Heinemann (1) - Bernhard Hemmer (1) Mohamed Oukka (2) - Ari Waisman (3) - Thomas Korn (1) Technical University Munich, Klinikum Rechts Der Isar, Neurology, Munich, Germany (1) - University Of Washington, Seattle Children’s Research Institute - Center For Immunity And Immunotherapies, Seattle, United States (2) Johannes Gutenberg University Mainz, Institute For Molecular Medicine, Mainz, Germany (3)

15

Scientific Program

NOVEL TECHNICAL APPROACHES IN DIFFERENT DISEASE MODELS 13:45 - 15:15 ROOM B (GUTENBERGSAAL 1)

Chair: Anne H. Cross

13:45 336 - FOLLOWING ANTI-CD20 TREATMENT, COMPARTMENT-SPECIFIC REPLETION WITH IMMUNE-COMPETENT B CELLS DEPENDS ON ACTIVATION OF REAPPEARING B CELLS Linda Feldmann - Martin S. Weber Department Of Neuropathology, University Medical Center Göttingen, Göttingen, Germany

14:00 274 - IN SITU MICRORNA PROFILES OF ASTROCYTES IN THE CONTEXT OF ISCHEMIC BRAIN INJURY AND MULTIPLE SCLEROSIS Vijayaraghava Rao (1) - Fuh Shih-chieh (1) - Craig Moore (2) - Samuel Ludwin (3) - Rosanne Séguin (1) Ming-kai Ho (1) - Barry Bedell (1) - Amit Bar-or (1) - Jack Antel (1) Mcgill University, Montréal Neurological Institute, Montréal, Canada (1) - Memorial University, Health Sciences Centre, St. John’s, Canada (2) - Queen’s University, Department Of Pathology And Molecular Medicine, Kingston, Canada (3)

14:15 279 - MIR-223 REGULATES MYELOID DERIVED SUPPRESSOR CELLS DURING EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS Claudia Cantoni (1) - Todd Fehniger (2) - Anne Cross (1) - Laura Piccio (1) Washington University In St Louis, Department Of Neurology, St. Louis, United States (1) Washington University In St Louis, Department Of Internal Medicine, St. Louis, United States (2)

14:30 40 - THE PROTEOME PROFILE OF THE URINE IS DIFFERENT IN PATIENTS WITH NEUROMYELITIS OPTICA COMPARED TO MULTIPLE SCLEROSIS AND HEALTHY SUBJECTS Helle Hvilsted Nielsen (1) - Lars P Kristensen (2) - Hans C Beck (2) - Jay Reddy (3) - Zsolt Illes (1) University Of Southern Denmark, Odense University Hospital, Odense, Denmark (1) - Center For Clinical Proteomics, Odense University Hospital, Odense, Denmark (2) - School Of Veterinary Medicine And Biomedical Sciences, University Of Nebraska-lincoln, Lincoln, United States (3)

14:45 303 - LOSS OF IGF1R FROM OLIGODENDROCYTES AMELIORATES NEUROINFLAMMATION WITHOUT AFFECTING CELL SURVIVAL Giuseppe Locatelli (1) - Martin Krüger (2) - Olivia Prazeres Da Costa (3) - Barbara Ingold-heppner (4) Linda Koch (5) - Bettina Schreiner (6) - Jens Brüning (5) - Ingo Bechmann (2) - Burkhard Becher (6) Thorsten Buch (3) Institute Of Clinical Neuroimmunology, Ludwig-maximilian Universität München, Munich, Germany (1) Institute Of Anatomy, University Of Leipzig, Leipzig, Germany (2) - Institute For Med. Microbiology, Immunology And Hygiene, Technische Universität München, Munich, Germany (3) - Institute Of Pathology, Charité – universitätsmedizin Berlin, Berlin, Germany (4) - Institute For Genetics, University Of Cologne, Cologne, Germany (5) - Institute For Exp. Immunology, University Of Zurich, Zurich, Germany (6)

15:00 532 - IDENTIFICATION OF A TRANSCRIPTIONAL REGULATOR OF PATHOGENICITY OF TH17 CELLS. Gerd Meyer Zu Horste - Chuan Wu - Youjin Lee - Wassim Elyaman - Vijay K Kuchroo Center For Neurologic Diseases, Brigham And Women’s Hospital / Harvward Medical School, Boston, United States

MECHANISMS AND THERAPIES OF CNS DISEASE 13:45 - 15:15 ROOM C (GUTENBERGSAAL 2)

Chair: Sandra Amor

13:45 122 - DEMYELINATION DURING MULTIPLE SCLEROSIS IS ASSOCIATED WITH COMBINED ACTIVATION OF MICROGLIA AND MACROPHAGES BY IFN-GAMMA AND ALPHA B-CRYSTALLIN Malika Bsibsi (1) - Laura Peferoen (2) - Inge Holtman (3) - Peter Nacken (1) - Wouter Gerritsen (4) Maarten Witte (5) - Jack Van Horssen (5) - Bart Eggen (3) - Paul Van Der Valk (4) - Sandra Amor (4) Johannes Van Noort (1)

Delta Crystallon, -, Leiden, Netherlands (1) - Dept .pathology, Vumc, Amsterdam, Netherlands (2) - Dept. Medical



Physiology, Umcg, Groningen, Netherlands (3) - Dept. Pathology, Vumc, Amsterdam, Netherlands (4) Dept. Molecular Cell Biology And Immunology, Vumc, Amsterdam, Netherlands (5)

14:00 444 - DETECTION OF AUTO-ANTIBODIES TO LEOMODIN-1 IN PATIENTS WITH NODDING SYNDROME Tory Johnson (1) - Richa Tyagi (1) - Paul R Lee (1) - Myoung-hwa Lee (1) - Kory R Johnson (1) Jeffery Kowalak (1) - Marie Medynets (1) - Alina Hategan (1) - Thomas B Nutman (2) - James Sejvar (3) Issa Makumbi (4) - Jane R Aceng (4) - Scott F Dowell (5) - Avindra Nath (1)

Ninds, National Institutes Of Health, Bethesda, Md, United States (1) - Niaid, National Institutes Of Health, Bethesda, Md, United States (2) - National Center For Emerging And Zoonotic Infectious Diseases, Center For Disease Control And Prevention, Atlanta, Ga, United States (3) - Ministry Of Health, Uganda, Kampala, Uganda (4) - Center For Global Health, Center For Disease Control And Prevention, Atlanta, Ga, United States (5)

4:15 305 - PLP1 MUTATIONS IN PATIENTS WITH MULTIPLE SCLEROSIS: IDENTIFICATION OF A NEW MUTATION AND ANALYSIS OF IN VITRO EFFECTS OF PLP1 MUTATIONS. Nancy Cloake (1) - Jun Yan (1) - Michael Pender (2) - Atefeh Aminian (1) - Judith Greer (1) Uq Centre For Clinical Research, The University Of Queensland, Brisbane, Australia (1) - School Of Medicine, The University Of Queensland, Brisbane, Australia (2)

14:30 62 - IMAGING GENERATION AND ACTION OF REACTIVE SPECIES IN AN ANIMAL MODEL OF MULTIPLE SCLEROSIS: FOCUS ON AXONAL PATHOLOGY Giuseppe Locatelli Institute Of Clinical Neuroimmunology, Ludwig-maximilians Universität München, München, Germany

14:45 107 - FINGOLIMOD TREATMENT PROMOTES REGULATORY B-CELL PHENOTYPE AND FUNCTION IN MULTIPLE SCLEROSIS Berit Grützke (1) - Stephanie Hucke (1) - Brigitte Wildemann (2) - Thomas Dehmel (3) - Bernd Kieseier (3) Anita Posevitz-feijfar (1) - Heinz Wiendl (1) - Luisa Klotz (1) Department Of Neurology, University Hospital Münster, Münster, Germany (1) - Department Of Neurology, Universityhospital Heidelberg, Heidelberg, Germany (2) - Department Of Neurology, University Hospital Düsseldorf, Düsseldorf, Germany (3)

15:00 584 - CNS DCS MODULATE PERIPHERAL ANTI CNS IMMUNITY Mohammad Mohammad (1) - Vicky Wang Wei Tsai (1) - Marc Ruitenberg (2) - Masoud Hassanpour (1) Hui Li (1) - Prue Hart (3) - Samuel Breit (1) - Paul Sawchenko (4) - David Brown (1) Peter Duncan Neurosciences Research Centre, St Vincent’s Centre For Applied Medical Research And University Of Nsw, Sydney, Australia (1) - School Of Biomedical Sciences And Queensland Brain Institute, The University Of Queensland, Brisbane, Australia (2) - Telethon Institute For Child Health Research, University Of Western Australia, Perth, Australia (3) - Laboratory Of Neuronal Structure And Function, The Salk Institute For Biological Studies, La Jolla, United States (4)

COFFEE BREAK & POSTER SESSION | B-CELLS AND ANTIBODIES 15:15 - 16:45 POSTERHALL (RHEINFOYER)

242 - B CELL IRF1 PATHWAY IS DYSREGULATED IN MULTIPLE SCLEROSISViviana Annibali (1) - Renato Umeton (1) - Antonia Palermo (1) - Maria Chiara Buscarinu (1) - Claudia Policano (1) Rosella Mechelli (1) - Silvia Romano (1) - Daniela F. Angelini (2) - Eleonora Piras (2) - Gianluca Mattei (1) - Vito Antonio Gerardo Ricigliano (1) - Anita Annese (1) - Luca Battistini (2) - Marco Salvetti (1) - Giovanni Ristori (1)

Centre For Experimental Neurological Therapies (centers) - Dep. Of Neurosciences, Mental Health And Sensory Organs., Sapienza, University Of Rome, S. Andrea Hospital Site., Rome, Italy (1) - Neuroimmunology Unit., Santa Lucia Foundation., Rome, Italy (2)

210 - ANTI-CD20 THERAPY DOWN-REGULATES LESION FORMATION AND MICROGLIAL ACTIVATION IN PATTERN I AND PATTERN II RAT MODELS OF MULTIPLE SCLEROSISDaniel C Anthony (1) - Alex M Dickens (1) - Nicholas Seneca (2) - Yvonne Couch (1) - Sandra Campbell (1) - Begona Checa (3) - Veerle Kersemans (4) - Edward A Warren (1) - Matthew Tredwell (3) - Nicola R Sibson (4) - Veronique Gouverneur (3) - David Leppert (2)

Department Of Pharmacology - Experimental Neurology, University Of Oxford, Oxford, United Kingdom (1) - F. Hoffmann-la Roche Ltd, Building 74/3w.306a, Basel, Switzerland (2) - Department Of Chemistry, University Of Oxford, Oxford, United Kingdom (3) - Cr-uk/mrc Gray Institute For Radiation Oncology And Biology, University Of Oxford, Oxford, United Kingdom (4)

17

Scientific Program

614 - ANALYSIS OF AUTOANTIBODIES AGAINST ANTIGENS OF THE INHIBITORY SYNAPSIS IN PATIENTS WITH NON-PARANEOPLASTIC NEUROLOGICAL SYNDROMES AND GAD65 ANTIBODIESNuria Gresa-arribas (1) - Helena Ariño (2) - Eugenia Martínez-hernández (2) - Mar Petit-pedrol (1) - Merce Alba (1) Eva Caballero (1) - Esther Aguilar (1) - Albert Saiz (2) - Josep Dalmau (3) - Francesc Graus (2)

Neuroimmunology Program, Idibaps, Barcelona, Spain (1) - Neurology Service, Hospital Clinic, Barcelona, Spain (2) - Institucio Catalana De Recerca I Estudis Avançats, Icrea, Barcelona, Spain (3)

629 - MS CSF-DERIVED RECOMBINANT ANTIBODIES CAUSE CENTRAL NERVOUS SYSTEM DEMYELINATIONKevin Blauth - John Soltys - Alanna Ritchie - Cory Reiter - Sean Selva - Adeline Matschulat - Jeffrey Bennett Gregory Owens University Of Colorado Anschutz Medical Campus, Department Of Neurology, Aurora, Co, United States

119 - B-CELL MARKERS FROM THE BAFF FAMILY AS PREDICTORS FOR EXPERIMENTAL AUTOIMMUNE MYASTHENIA GRAVIS AGGRAVATION IN MICE LACKING PLASMINOGEN ACTIVATOR COMPONENTSTalma Brenner - Tehila Mizrachi - Devorah Gur-wahnon - Camille Sicsic - Abd Al-roof Higazi Hadassah Medical Center, Hadassah Hebrew University, Jerusalem, Israel

272 - A MONOCLONAL ANTIBODY FROM A MOTHER OF A CHILD WITH AUTISM RESULTED IN CORTICAL AND BEHAVIORAL ALTERATIONS IN MALE BUT NOT FEMALE MICE.Lior Brimberg - Simone Madar - Venkatesh Jeganathan - Roseann Berlin - Cassaundra Smith - Patricio Huerta - Bruce Volpe - Betty Diamond Feinstein Institute For Medical Research, North Shore University Hospital, Manhasset, United States

616 - HUMAN PERM IGG INDUCES MOTOR DYSFUNCTION IN MICEAlexander Carvajal - Leslie Jacobson - Linda Clover - Bethan Lang - Angela Vincent University Of Oxford, John Radcliffe Hospital, Oxford, United Kingdom

624 - DYNAMICS OF B CELL SUBSETS WITHIN THE CNS DURING VIRAL ENCEPHALOMYELITISKrista Disano (1) - Timothy Phares (2) - Cornelia Bergmann (2)

Cleveland Clinic Foundation, Kent State University, Cleveland, United States (1) - Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, United States (2)

234 - GAD65 EPITOPE MAPPING IN DISTINCT CNS SYNDROMESPinelopi Fouka (1) - Harry Alexopoulos (1) - Panos Politis (2) - Marinos Dalakas (1)

Neuroimmunology Unit, Department Of Pathophysiology, Faculty Of Medicine, National And Kapodistrian University Of Athens, Athens, Greece (1) - Department Of Histology, Biomedical Research Foundation, Academy Of Athens, Athens, Greece (2)

183 - STUDY OF THE ROLE OF SECONDARY DIVERSIFICATION OF B CELL RECEPTOR IN EAEGeorgina Galicia University Of Toronto, University Of Toronto, Toronto, Canada

518 - AUTOIMMUNE ENCEPHALITIS: SINGLE CELL PCR ANALYSIS OF THE INTRATHECAL PLASMA CELL REPERTOIREManish Malviya (1) - Nico Melzer (2) - Guido Widman (3) - Christian Elger (3) - Heinz Wiendl (2) - Hans-peter Hartung (1) Norbert Goebels (1)

Department Of Neurology, Heinrich-heine-university, Duesseldorf, Germany (1) - Department Of Neurology, University Of Muenster, Muenster, Germany (2) - Department Of Epileptology, University Of Bonn, Bonn, Germany (3)

228 - B CELL FOLLICLE LIKE STRUCTURES IN MULTIPLE SCLEROSISMorten Haugen (1) - Jette L Frederiksen (2) - Matilda Degn (2)

Faculty Of Health And Medical Sciences, University Of Copenhagen, Copenhagen, Denmark (1) - Department Of Neurology, Copenhagen University Hospital, Glostrup, Denmark (2)

316 - ADAM10 RELEASES THE IMMUNOREGULATOR SOLUBLE TACI - A NOVEL BIOMARKER FOR B-CELL PATHOLOGIESFranziska Hoffmann Institute Of Clinical Neuroimmunology, Ludwig Maximilian University, Munich, Germany



125 - IMMUNOAFFINITY PURIFICATION AND CHARACTERIZATION OF SPECIFIC ANTIBODIES AGAINST RECOMBINANT TAU PROTEIN FROM INTRAVENOUS IMMUNOGLOBULIN PRODUCTLenka Hromadkova (1) - Michala Kolarova (1) - Barbora Jankovicova (2) - Ales Bartos (1) - Jan Ricny (1) - Zuzana Bilkova (2) Daniela Ripova (1)

Laboratory Of Biochemistry And Brain Pathophysiology And Ad Center, Prague Psychiatric Centre, Prague, Czech Republic (1) Department Of Biological And Biochemical Sciences, University Of Pardubice, Pardubice, Czech Republic (2)

630 - CELL-SURFACE NEURONAL ANTIBODIES IN PATIENTS WITH JAPANESE ENCEPHALITIS VIRUSAnjan Nibber (1) - Bethan Lang (1) - Bridget Wills (2) - Angela Vincent (1) - Sarosh Irani (1)

Nuffield Department Of Clinical Neurosciences, University Of Oxford, Oxford, United Kingdom (1) - Oxford University Clinical Research Unit, Hospital For Tropical Diseases, Vietnam, Viet Nam (2)

214 - PROCESSING OF MOG IS AFFECTED BY POST-TRANSLATIONAL MODIFICATION IN VIRUS INFECTED NON-HUMAN PRIMATE B CELLSAnwar Jagessar (1) - Karin Dijkman (2) - Sam Hofman (1) - Nicole Heijmans (1) - Bart Faber (1) - Sander Van Kasteren (3) Bogdan Blorea (4) - Bert ‘t Hart (1)

Biomedical Primate Research Centre, Biomedical Primate Research Centre, Rijswijk, Netherlands (1) - Dept. Immunobiology, Biomedical Primate Research Centre, Rijswijk, - (2) - Leiden Institute Of Chemistry, Leiden Univeristy, Leiden, Netherlands (3) Leiden Institute Of Chemistry, Leiden University, Leiden, Netherlands (4)

554 - B CELL DEPLETION ALTERS T CELL HOMINGYolanda Kap (1) - Nikki Van Driel (1) - Bert ‘t Hart (1)

Department Of Immunobiology, Biomedical Primate Research Centre, Rijswijk, Netherlands (1)

249 - MYELIN-SPECIFIC ANTIBODIES TRIGGER SPONTANEOUS CNS AUTOIMMUNE DISEASE IN THE ABSENCE OF MYELIN-SPECIFIC B CELLSSilke Kinzel (1) - Klaus Lehmann-horn (2) - Scott S. Zamvil (3) - Anne Winkler (1) - Claude C. Bernard (4) Christine Stadelmann-nessler (1) - Wolfgang Brück (1) - Martin S. Weber (1)

Institute Of Neuropathology, University Medical Centre, Göttingen, Germany (1) - Department Of Neurology, Technische Universität München, Munich, Germany (2) - Department Of Neurology And Program In Immunology, University Of California, San Francisco, United States (3) - Monash Immunology And Stem Cell Laboratories, Monash University, Clayton, Australia (4)

456 - AUTOANTIBODIES AGAINST IGLON5: TWO NEW CASESRamona Bahtz (1) - Bianca Teegen (1) - Kathrin Borowski (1) - Christian Probst (1) - Inga-madeleine Blöcker (1) - Kai Fechner (1) - Silvia Parigger (2) - Gerhard Daniel (2) - Thomas Brücke (2) - Ann-sophie Lauenstein (3) - Bertold Schrank (3) Winfried Stöcker (1) - Lars Komorowski (1)

Institute Of Experimental Immunology, Euroimmun Ag, Lübeck, Germany (1) - Department Of Neurology, Wilhelminenspital, Vienna, Austria (2) - Department Of Neurology, German Clinic For Diagnostics, Wiesbaden, Germany (3)

84 - ELECTROPHYSIOLOGICAL FEATURES OF GUILLAIN-BARRE SYNDROME ASSOCIATED WITH ANTI-GALACTOCEREBROSIDE ANTIBODIES AS WELL AS ANTI-GANGLIOSIDE ANTIBODIESSusumu Kusunoki (1) - Makoto Samukawa (1) - Yukihiro Hamada (1) - Motoi Kuwahara (1) - Kazuo Takada (1) Makito Hirano (1) - Yoshiyuki Mitsui (1)

Department Of Neurology, Faculty Of Medicine, Kinki University, Osaka-sayama, Japan (1)

427 - INTRATHECAL PRODUCTION OF ANTIBODIES AGAINST JC VIRUS AND OTHER VIRUSES IN MULTIPLE SCLEROSIS AND NATALIZUMAB-ASSOCIATED PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHYFabienne Largey - Ivan Jelcic - Mireia Sospedra - Roland Martin - Ilijas Jelcic Neuroimmunology And Multiple Sclerosis Research Section, University Hospital Of Zurich, Zurich, Switzerland

282 - LIMBIC ENCEPHALITIS WITH ANTIBODIES TO LGI1 IS ASSOCIATED WITH AN ACTIVE INTRATHECAL B CELL RESPONSEKlaus Lehmann-horn (1) - Sarosh Irani (2) - Shengzhi Wang (1) - Jeffrey Gelfand (1) - Michael Geschwind (1) - Scott Zamvil (1) - H.-christian Von Büdingen (1)

Department Of Neurology, University Of California, San Francisco, San Francisco, United States (1) - Nuffield Department Of Clinical Neurosciences, University Of Oxford, Oxford, United Kingdom (2)

277 - AQP4-IGG PLACENTAL TRANSFER IN NMO PREGNANCIESSimone Mader (1) - Lior Brimberg (1) - Alexandre Bonnin (2) - Jeffrey L. Bennett (3) - Betty Diamond (1)

The Feinstein Institute For Medical Research, North Shore Long Island Jewish Health System, New York, United States (1)

19

Scientific Program

Keck School Of Medicine Of University Of Southern California, Zilkha Neurogenetic Institute, Los Angeles, United States (2) Departments Of Neurology & Ophthalmology, University Of Colorado Denver, Denver, United States (3)

403 - IL-33/ST2 AXIS MEDIATES RESISTANCE TO EAE BY PROMOTING REGULATORY B AND TOLEROGENIC DENDRITIC CELLSBojana Stojanovic - Jelena Milovanovic - Aleksandar Arsenijevic - Marija Milovanovic - Nebojsa Arsenijevic Miodrag L. Lukic Center For Molecular Medicine And Stem Cell Research, Faculty Of Medical Sciences University Of Kragujevac, Kragujevac, Serbia

549 - INTRATHECAL IGM PRODUCTION CORRELATES WITH MORE SEVERE DISEASE COURSE IN MULTIPLE SCLEROSIS: CLINICAL AND MRI RESULTSSerkan Ozakbas (1) - Bilge Piri Cinar (2) - Pinar Ozcelik (1) - Hatice Baser (1) - Görkem Kosehasanogullari (3)

Department Of Neurology, Dokuz Eylul University, Izmir, Turkey (1) - Department Of Neurology, Giresun State Hospital, Giresun, Turkey (2) - Department Of Neurology, Usak State Hospital, Usak, Turkey (3)

605 - ANTI-MYELIN ANTIBODY RESPONSES FOLLOWING INDUCTION OF ANTIGEN-SPECIFIC TOLERANCE WITH ANTIGEN-COUPLED CELLSPatrick Peschl (1) - Markus Reindl (1) - Kathrin Schanda (1) - Mireia Sospedra (2) - Roland Martin (2) - Andreas Lutterotti (1)

Clinical Department Of Neurology, Innsbruck Medical University, Innsbruck, Austria (1) - Neuroimmunology And Multiple Sclerosis Research, Department Of Neurology, University Hospital Zurich, Zurich, Switzerland (2)

221 - A ROLE FOR REGULATORY B CELLS IN PREVENTING THE PROGRESSION OF MULTIPLE SCLEROSIS Federica Piancone - Francesca La Rosa - Ivana Marventano - Laura Mendozzi - Domenico Caputo - Marco Rovaris Marina Saresella - Mario Clerici Don Gnocchi Foundation S. Maria Nascente, Don Gnocchi Foundation, Milan, Italy

606 - A HIGHLY SENSITIVE LIVE CELL BASED ASSAY FOR DETECTION OF ANTIBODIES AGAINST N-METHYL-D-ASPARTATE RECEPTORSMelanie Ramberger (1) - Patrick Peschl (1) - Kathrin Schanda (1) - Romana Höftberger (2) - Florian Deisenhammer (1) Kevin Rostásy (3) - Thomas Berger (1) - Josep Dalmau (4) - Markus Reindl (1)

Clinical Department Of Neurology, Innsbruck Medical University, Innsbruck, Austria (1) - Institute Of Neurology, Medical University Vienna, Vienna, Austria (2) - Department Of Pediatrics I, Division Of Pediatric Neurology, Innsbruck Medical University, Innsbruck, Austria (3) - Institució Catalana De Recerca I Estudis Avançats (icrea), Idibaps, Hospital Clínic, Barcelona, Spain (4)

148 - TAKING A CLOSER LOOK AT SPAG16 IN MULTIPLE SCLEROSISLaura De Bock (1) - Klaartje Somers (1) - Judith Fraussen (1) - Jerome Hendriks (1) - Jack Van Horssen (2) - Myrthe Rouwette (1) - Niels Hellings (1) - Luisa M Villar (3) - José C. Álvarez-cermeño (3) - Mercedes Espiño (3) - Raymond Hupperts (4) - Peter Jongen (5) - Jan Damoiseaux (6) - Marcel M. Verbeek (7) - Peter P. De Deyn (8) - Marie D’hooghe (9) Bart Van Wijmeersch (1) - Piet Stinissen (1) - Veerle Somers (1)

Biomedical Research Institute, Hasselt University, Diepenbeek, Belgium (1) - Department Of Molecular Cell Biology And Immunology, Vu University Medical Center, Amsterdam, Netherlands (2) - Departments Of Neurology And Immunology, Ramón Y Cajal Hospital, Madrid, Spain (3) - Department Of Neurology, Orbis Medical Center, Sittard, Netherlands (4) - Ms4 Research Institute, /, Nijmegen, Netherlands (5) - Maastricht University Medical Centre, Maastricht University, Maastricht, Netherlands (6) - Radboud University Medical Center, Radboud Universiteit, Nijmegen, Netherlands (7) - Department Of Neurology, Middelheim Hospital, Antwerp University, Antwerp, Belgium (8) - Department Of Neurology, National Ms Center,, University Hospital Brussel, Melsbroek, Belgium (9)

318 - MYELIN OLIGODENDROCYTE GLYCOPROTEIN SPECIFIC AUTOANTIBODIES IN ADULT PATIENTS WITH DIFFERENT INFLAMMATORY DISEASES OF THE CNSMelania Spadaro (1) - Lisa Gerdes (1) - Cathrin Mayer (1) - Elisabeth Schuh (1) - Franziska Hoffmann (1) - Sarah Laurent (1) Hans Lassmann (2) - Reinhard Hohlfeld (1) - Tania Kümpfel (1) - Edgar Meinl (1)

Institute Of Clinical Neuroimmunology,, Ludwig Maximilian University, Munich, Germany (1) - Division Of Neuroimmunology, Centre For Brain Research,, Medical University Of Vienna, Vienna, Austria (2)

335 - CHARACTERIZATION OF RESIDENT PLASMA CELLS IN AND THEIR MIGRATION TO THE INFLAMED CENTRAL NERVOUS SYSTEM DURING EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITISCarolin Ulbricht (1) - Karolin Pollok-trage (1) - Jöran Keßler (1) - Robert Günther (2) - Katharina Horn (2) - Sabrina Schlüngel (2) - Friedemann Paul (1) - Raluca Niesner (2) - Helena Radbruch (1) - Anja E. Hauser (1)

Neurocure, Charité University Of Medicine, Berlin, Germany (1) - German Rheumatism Research Center, A Leibniz Institute, Berlin, Germany (2)



633 - ASSESSMENT OF AQUAPORIN-4 (AQP4) ANTIBODY ASSAYS IN EUROPEAN DIAGNOSTIC CENTRESPatrick Waters (1) - Markus Reindl (2) - Kathrin Schanda (2) - Friederike Tuller (2) - Vlastimil Kral (3) - Petra Nytrova (3) Ondrej Sobek (4) - Helle Hvilsted Nielsen (5) - Zsolt Illés (6) - Torben Barington (5) - Søren Thue Lillevang (5) - Winfried Stöcker (7) - Kristin Rentzsch (7) - Christian Probst (7) - Sandra Saschenbrecker (7) - Christine Klingbeil (7) - Ulrike Krummrei (7) - Achim Berthele (8) - Timea Berki (9) - Letizia Granieri (10) - Antonio Bertolotto (10) - Bruno Giometto (11) Luigi Zuliani (11) - Dörte Hamann (12) - Albert Saiz (13) - Romana Höftberger (13) - Manuel Comabella (14) - Carme Costa Riu (14) - Aksel Siva (15) - Ayse Altintas (15) - Günnur Deniz (15) - Angela Vincent (1) - M. Isabel Leite (1) - Mark Woodhall (1) Jacqueline Palace (1) - Friedemann Paul (16) - Orhan Aktas (17) - Sven Jarius (18) - Christian Vedeler (19) - Anne Ruiz (20) Romain Marignier (20)

University Of Oxford, Nuffield Dept. Of Clinical Neurosciences, Oxford, United Kingdom (1) - Innsbruck Medical University, Clinical Dept. Of Neurology, Innsbruck, Austria (2) - Zdravotni Ustav Se Sidlem V Usti Nad Labem, Centrum Imunologie A Mikrobiologie, Usti Nad Labem, Czech Republic (3) - Topelex Ltd, Laboratory For Csf And Neuroimmunology, Prague, Czech Republic (4) Odense University Hospital, Dept. Of Neurology, Odense, Denmark (5) - Odense University Hospital, Dept. Of Neurology, Odense, Denmark / University Of Pécs, Department Of Immunology And Biotechnology, Pécs, Hungary (6) - Euroimmun Ag, Lübeck, Germany (7) Klinikum Rechts Der Isar Der Tu München, Klinik Für Neurologie, Munich, Germany (8) - University Of Pécs, Department Of Immunology And Biotechnology, Pécs, Hungary (9) - Neuroscience Institute Cavalieri Ottolenghi (nico), University Hospital San Luigi Gonzaga, Clinical Neurobiology Unit – Regional Referring Multiple Sclerosis Centre, Orbassano, Italy (10) - Azienda Ulss 9 Treviso, Dept. Of Neurology, Treviso, Italy (11) - Sanquin Diagnostic Services/ Erasmusmc, Dept. Of Immunopathology And Blood Coagulation, Amsterdam, Netherlands (12) - Neuroimmunology Group, Service Of Neurology, Universitat De Barcelona And Institut D’ Investigació Biomèdica August Pi I Sunyer, Barcelona, Spain (13) - Institut De Recerca – Edifici Mediterrrània, Hospital Universitari Vall D’hebron, Barcelona, Spain (14) - Istanbul University Cerrahpasa School Of Medicine, Neurology Department, Istanbul,turkey (15) - Neurocure Clinical Research Center (ncrc), Charité Universitätsmedizin Berlin, Berlin, Germany (16) - Heinrich-heine-university Düsseldorf, Department Of Neurology, Düsseldorf, Germany (17) - Otto Meyerhof Zentrum, Heidelberg, Germany (18) - Haukeland University Hospital, Department Of Neurology, Bergen, Norway (19) - Lyon Neurosciences Research Centre, Neuro-inflammation And Neuro-oncology Team, Faculty Of Medecine Rth Laennec, Lyon, France (20)

291 - INTRATHECAL IGG FROM PATIENTS WITH MULTIPLE SCLEROSIS TARGET PATIENT-SPECIFIC PHAGE PEPTIDESTiffany Pointon (1) - Sean Manton (1) - Mollie Davis (1) - Gino Braiotta (1) - Laura Schambers (1) - Taylor Edwards (1) - Bailey Polonsky (1) - Michael Graner (2) - Mark Burgoon (1) - Xiaoli Yu (1)

University Of Colorado Anschutz Medical Campus, Neurology, University Of Colorado Anschutz Medical Campus, Aurora, United States (1) University Of Colorado Anschutz Medical Campus, Neurosurgery, University Of Colorado Anschutz Medical Campus, Aurora, United States (2)

515 - THE IDENTITY OF OLIGOCLONAL BANDS IN PATIENTS WITH MULTIPLE SCLEROSISXiaoli Yu (1)

Department Of Neurology, University Of Colorado School Of Medicine, Aurora, United States (1)

COFFEE BREAK & POSTER SESSION | BIOMARKERS 15:15 - 16:45 POSTERHALL (RHEINFOYER)

578 - A NOVEL PREDICTIVE FACTOR, SORCIN ANTIBODY IN CONVERSION OF RADIOLOGICALLY ISOLATED SYNDROME TO MULTIPLE SCLEROSISEce Erdag (1) - Elcin Sehitoglu (1) - Melike Kucukerden (1) - Arda Orcen (1) - Erdem Tuzun (1) - Recai Turkoglu (2)

Institute For Experimental Medicine, Istanbul University, Istanbul, Turkey (1) - -, Haydarpasa Numune Education And Research Hospital, Istanbul, Turkey (2)

180 - NOVEL GENETIC MARKERS, ASSOCIATED WITH FIRST REMISSION DURATION IN MULTIPLE SCLEROSIS, AS PREDICTOR OF THE FOLLOWING DISEASE SEVERITY IN RUSSIAN PATIENTSVitalina Bashinskaya - Ekaterina Tsareva - Olga Kulakova - Ivan Kiselev - Alexey Boyko - Olga FavorovaPirogov Russian National Research Medical University, N.i. Pirogov Russian National Research Medical University, Moscow, Russian Federation

591 - GENE EXPRESSION PROFILING AND IMMUNOPHENOTYPING ASSOCIATED WITH DIFFERENT CLINICAL FORMS AND ACTIVITY PHASES OF MULTIPLE SCLEROSISNicolas Fissolo - Ramil Nurtdinov - Laura Negrotto - Sunny Malhotra - Angela Vidal-jordana - Joaquín Castilló Xavier Montalban - Manuel Comabella Servei De Neurologia-neuroimmunologia. Centre D’esclerosi Múltiple De Catalunya (cemcat). Institut De Receca Vall D’hebron (vhir)., Hospital Universitari Vall D’hebron. Universitat Autònoma De Barcelona, Barcelona, Spain

21

Scientific Program

551 - NO CORRELATION BETWEEN KIR 4.1 AUTOIMMUNITY AND MULTIPLE SCLEROSISJustyna Maria Czarna BahlDepartment Of Clinical Biochemistry, Immunology And Genetics, Statens Serum Institut, Copenhagen, Denmark

645 - CEREBROSPINAL FLUID LIGHT NEUROFILAMENTS AS A THERAPEUTIC MARKER OF RESPONSE IN MODIFYING THERAPIES DISEASE IN MULTIPLE SCLEROSISFabian Gomez - Carlos OehningerUniversity Of Uruguay, Clinical Hospital, Montevideo, Uruguay

593 - THE EXPRESSIONS OF APOPTOTIC-RELATED GENES IN PATIENTS WITH THE CLINICALLY ISOLATED SYNDROME: A FOLLOW-UP STUDYSanna Hagman (1) - Pabitra Basnyat (1) - Marcin Kolasa (1) - Mika Helminen (2) - Prasun Dastidar (3) - Irina Elovaara (4)

Neuroimmunology Unit, Medical School, University Of Tampere, Tampere, Finland (1) - School Of Health Sciences, University Of Tampere, Tampere, Finland (2) - Medical Imaging Centre, Department Of Diagnostic Radiology, Tampere University Hospital, Tampere, Finland (3) - Neuroimmunology Unit, Medical School, University Of Tampere, Tampere, Finland (4)

165 - RELATIONSHIP BETWEEN IMAGING AND BLOOD-BASED TRANSCRIPTION PROFILES IN PRIMARY-PROGRESSIVE MULTIPLE SCLEROSISMatilde Inglese (1) - Christophe Gerald (2) - Roxana Teodorescu (2) - Colleen Farrell (2) - Michelle Fabian (2) - Fred Lublin (2)

Department Of Neurology, Radiology, Neuroscience, Icahn School Of Medicine At Mount Sinai, New York, United States (1) Department Of Neurology, Icahn School Of Medicine At Mount Sinai, New York, United States (2)

140 - INVESTIGATION OF SEMA4A AS A BIOMARKER FOR TREATMENT SELECTION FOR MULTIPLE SCLEROSISToru Koda (1) - Tatsusada Okuno (1) - Yuji Nakatsuji (1) - Kazushiro Takata (1) - Josephe Archie Honorat (1) Akiko Namba (1) - Saburo Sakoda (2) - Atsushi Kumanogoh (3) - Hideki Mochizuki (1)

Departments Of Neurology, Osaka University Graduate School Of Medicine, Osaka, Japan (1) - National Hospital Organization, Toneyama National Hospital, Osaka, Japan (2) - Departments Of Respiratory Medicine, Allergy And Rheumatic Diseases, Osaka University Graduate School Of Medicine, Osaka, Japan (3)

95 - A NEW RECOMBINANT CELL-BASED IFA FOR THE DETERMINATION OF AUTOANTIBODIES TO GAD IN STIFF-PERSON SYNDROMEInga-madeleine Blöcker (1) - Swantje Mindorf (1) - Winfried Stöcker (1) - Bettina Balint (2) - Hans-michael Meinck (3) - Lars Komorowski (1) - Christian Probst (1) - Wolfgang Schlumberger (1)

Institute Of Experimental Immunology, Euroimmun Ag, Lübeck, Germany (1) - Institute Of Neurology, University College London, London, United Kingdom (2) - Department Of Neurology, University Of Heidelberg, Heidelberg, Germany (3)

96 - AUTOANTIBODIES AGAINST GLYCINE-ASSOCIATED SYNAPTIC PROTEINS IN STIFF-PERSON SYNDROMEChristian Probst (1) - Inga-madeleine Blöcker (1) - Swantje Mindorf (1) - Mandy Unger (1) - Kai Fechner (1) - Hans-michael Meinck (2) - Bettina Balint (3) - Winfried Stöcker (1) - Wolfgang Schlumberger (1) - Lars Komorowski (1)

Institute Of Experimental Immunology, Euroimmun Ag, Lübeck, Germany (1) - Department Of Neurology, University Of Heidelberg, Heidelberg, Germany (2) - Institute Of Neurology, University College London, London, Germany (3)

94 - IDENTIFICATION OF THE INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1 AS A NEW AUTOANTIGEN OF PURKINJE CELLSMadeleine Scharf - Inga-madeleine Blöcker - Kathrin Borowski - Bianca Teegen - Nora Begemann - Yvonne Denno - Stephan Tiede - Winfried Stöcker - Christian Probst - Wolfgang Schlumberger - Lars Komorowski Institute Of Experimental Immunology, Euroimmun Ag, Lübeck, Germany

181 - GLATIRAMER ACETATE PHARMACOGENETICS IN RUSSIAN MULTIPLE SCLEROSIS PATIENTS: CLEC16A AND GPC5 AS NEW PLAYERSOlga Kulakova (1) - Ekaterina Tsareva (1) - Vitalina Bashinskaya (1) - Natalia Baulina (1) - Dmitrijs Lvovs (2) - Alexander Favorov (3) - Alexey Boyko (4) - Olga Favorova (1)

Pirogov Russian National Research Medical University, Pirogov Russian National Research Medical University, Moscow, Russian Federation (1) - Research Institute For Genetics And Selection Of Industrial Microorganisms, Research Institute For Genetics And Selection Of Industrial Microorganisms, Moscow, Russian Federation (2) - Johns Hopkins University School Of Medicine, Johns Hopkins University School Of Medicine, Baltimore, United States (3) - Pirogov Russian National Research Medical University, Moscow City Multiple Sclerosis Center, Moscow, Russian Federation (4)



477 - CSF BIOMARKERS OF INFLAMMATION AND NEURONAL DAMAGE IN ACUTE OPTIC NEURITIS PREDICT LATER DEVELOPMENT OF MS AND LONG-TERM DISABILITYSigne Modvig (1) - Matilda Degn (1) - Jette L Frederiksen (2) - Finn Sellebjerg (3)

Department Of Neurology, Hospital Of Glostrup, University Of Copenhagen, Glostrup, Denmark (1) - Department Of Neurology, Hospital Of Glostrup, University Of Copenhagen, Glostrup, Denmark (2) - Danish Multiple Sclerosis Centre, Department Of Neurology, Rigshospitalet, University Of Copenhagen, Copenhagen, Denmark (3)

597 - NON-INVASIVE SINGLE CELL-TRACKING IN MOUSE BRAIN BY USING TIME-LAPSE MRIYuki Mori - Yoshichika Yoshioka Immunology Frontier Research Center, Osaka University, Osaka, Japan

113 - IDENTIFICATION OF CANDIDATE PREDICTIVE PROTEIN BIOMARKERS BY M2 PROTEOMICS FOR CLINICAL ONSET AND TREATMENT EFFICACY OF MULTIPLE SCLEROSISItay Raphael - Thomas Forsthuber The University Of Texas At San Antonio, The University Of Texas At San Antonio, San Antonio, United States

495 - JCV INDEX AND L-SELECTIN FOR NATALIZUMAB-ASSOCIATED PML RISK STRATIFICATIONNicholas Schwab - Tilman Schneider-hohendorf - Johanna Breuer - Anita Posevitz-fejfar - Heinz Wiendl University Of Münster, University Clinic - Neurology, Münster, Germany

472 - DIFFERENTIAL GLYCOSYLATION OF KIR4.1 IN GLIAL CELLS AFFECTS BINDING OF AUTOANTIBODIES IN MULTIPLE SCLEROSIS Rajneesh Srivastava (1) - Sudhakar Reddy Kalluri (1) - Yvonne Schäfer (1) - Anita Krysta (1) - Verena Grummel (1) - Elisabeth Kremmer (2) - Dorothea Buck (1) - Lucas Schirmer (1) - Bernhard Hemmer (1)

Department Of Neurology, Klinikum Rechts Der Isar, Technische Universität, Munich, Munich, Germany (1) - Institute Of Molecular Immunology, Helmholtz Zentrummünchen, Germany, Munich, Germany (2)

323 - TREATMENT NON-RESPONSE TO BOSWELLIC ACIDS IS ASSOCIATED WITH MIR-302B EXPRESSION IN CD4+ T CELLS OF RELAPSING-REMITTING MULTIPLE SCLEROSIS PATIENTS IN THE SABA PROOF-OF-CONCEPT TRIALKlarissa Hanja Stürner (1) - Oliver Keminer (2) - Christoph Heesen (1) - Benjamin Otto (3) - Ole Pless (2)

Institute For Neuroimmunology And Multiple Sclerosis Research (inims), University Medical Center Hamburg-eppendorf, Hamburg, Germany (1) - European Screening Port, Center For Molecular Neurobiology Hamburg, Hamburg, Germany (2) - I. Department Of Internal Medicine, University Medical Center Hamburg-eppendorf, Hamburg, Germany (3)

78 - ANTIBODIES TO LRP4 IN SERUM AND CSF FROM AMYOTROPHIC LATERAL SCLEROSIS PATIENTSJohn Tzartos (1) - Paraskevi Zisimopoulou (2) - Michael Rentzos (3) - Nikos Karandreas (3) - Vasiliki Zouvelou (3) - Panagiota Evangelakou (4) - Anastasios Tsonis (4) - Thomas Thomaidis (5) - Giuseppe Lauria (6) - Francesca Andreetta (6) Renato Mantegazza (6) - Socrates Tzartos (2)

Hellenic Pasteur Institute, Red Cross Hospital, Athens, Greece (1) - Hellenic Pasteur Institute, Hellenic Pasteur Institute, Athens, Greece (2) Aeginition Hospital, National And Kapodistrian University, Athens, Greece (3) - Hellenic Pasteur Institute, Hellenic Pasteur, Athens, Greece (4) - Neurology Department, Red Cross Hospital, Athens, Greece (5) - Neurological Institute “carlo Besta”, Neurological Institute “Carlo Besta”, Milan, Italy (6)

250 - IGM (AND NOT IGG) OLIGOCLONAL BANDS: BIOMARKER OF TARGETABLE INFLAMMATION IN PPMSLuisa M Villar (1) - Amit Bar-or (2)

Servicios De Inmunología Y Neurología. Unidad De Esclerosis Múltiple., Hospital Universitario Ramón Y Cajal., Spain, Spain (1) Neuroimmunology Unit, Montréal Neurological Institute, Mcgill University (2)

COFFEE BREAK & POSTER SESSION | BLOOD BRAIN BARRIER 15:15 - 16:45 POSTERHALL (RHEINFOYER)

595 - NETRIN-1 REGULATES BLOOD-BRAIN BARRIER FUNCTION AND CNS INFLAMMATIONJorge Alvarez (1) - Cornelia Podjaski (1) - Lyne Bourbonniere (1) - Sandra Larouche (1) - Simone Terouz (1) - Marc-andre Lecuyer (1) - Lamia Hachehouche (1) - Akiko Nakano (1) - Mike Sabbagh (1) - Olivia Saint-laurent (1) - Catherine Larochelle (1) Jenea Bin (2) - Peter Darlington (2) - Nathalie Arbour (1) - Jack Antel (2) - Timothy Kennedy (2) - Alexandre Prat (1)

Centre De Recherche De Centre Hospitalier De L’université De Montréal, University, Montreal, Canada (1) - Mcgill University, University, Montreal, Canada (2)

23

Scientific Program

281 - INFLUENCE OF AGE-RELATED BLOOD BRAIN BARRIER MODIFICATIONS ON THE OUTCOME OF EXPERIMENTAL STROKE IN ELDERLY MICE.Marco Bacigaluppi - Mattia Gallizioli - Gianluca Luigi Russo - Giancarlo Comi - Gianvito Martino Neuroimmunology Unit, Institute Of Experimental Neurology, University Vita Salute San Raffaele And San Raffaele Hospital, Milan, Italy

321 - BLOOD-BRAIN BARRIER MARKERS AFTER ACUTE EPILEPTIC SEIZURES. Agnes Cudna - Iwona Kurkowska-jastrzebska Institute Of Psychiatry And Neurology, 2 Nd Department Of Neurology, Neuroimmunology Laboratory, Warsaw, Poland

621 - EFFECT OF HIV-REACTIVATING AGENTS ON BLOOD BRAIN BARRIER PERMEABILITY.Clelia Dental - Corine Barat - Michel Ouelet - Michel J. Tremblay (1)

Laboratoire D’immuno-rétrovirologie Humaine, Centre De Recherche Du Chuq, Pavillon Chul, Québec, Canada (1)

384 - THE ROLE OF THE MICRORNA-30 FAMILY IN THE REGULATION OF THE BLOOD-BRAIN BARRIER DURING INFLAMMATION. IMPLICATIONS FOR MULTIPLE SCLEROSISClaudio Derada Troletti (1) - Wouter W. Kamphuis (1) - Bert Van Het Hof (1) - Arie Reijerkerk (2) - Mark R. Mizee (1) Helga E. De Vries (1)

Blood-brain Barrier Research Group, Molecular Cell Biology And Immunology, Neuroscience Campus Amsterdam, Vu University Medical Center, Amsterdam, Netherlands (1) - To-bbb Technologies Bv, Leiden Bio Science Park, Leiden, Netherlands (2)

441 - DEFINING THE ROLES OF ICAM-1 AND ICAM-2 IN THE PATHOGENESIS OF EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITISNeda Haghayegh Jahromi (1) - Rémy Boscacci (1) - Michael Abadier (1) - Daniel C. Bullard (2) - Scott R. Barnum (3) Urban Deutsch (1) - Ruth Lyck (1) - Britta Engelhardt (1)

Theodor Kocher Institute, University Of Bern, Bern, Switzerland (1) - Departments Of Microbiology, University Of Alabama, Birmingham, United States (2) - Departments Of Genetics, University Of Alabama, Birmingham, United States (3)

508 - VLA-4 BLOCKADE PROMOTES DIFFERENTIAL ROUTES INTO HUMAN CNS INVOLVING PSGL-1-ROLLING OF T CELLS AND MCAM-ADHESION OF TH17 CELLSTilman Hohendorf (1) - Jan Rossaint (2) - Hema Mohan (1) - Daniel Böning (3) - Johanna Breuer (1) - Tanja Kuhlmann (4) Catharina Gross (1) - Ken Flanagan (5) - Lydia Sorokin (6) - Dietmar Vestweber (7) - Alexander Zarbock (2) - Nicholas Schwab (1) - Heinz Wiendl (1)

Neurology, University Of Muenster, Muenster, Germany (1) - Anaesthesiology, University Of Muenster, Muenster, Germany (2) - Medical Physics And Biophysics,, University Of Muenster, Muenster, Germany (3) - Neuropathology, University Of Muenster, Muenster, Germany (4) - Prothena, Corporation, San Francisco, United States (5) - Physiological Chemistry And Pathobiochemistry, University Of Muenster, Muenster, Germany (6) - Molecular Biomedicine, Max Plank, Muenster, Germany (7)

37 - PATHOGEN RECOGNITION REGULATES BLOOD-BRAIN BARRIER INTEGRITY AND PROTECTS AGAINST WEST NILE VIRUS ENTRY VIA TYPE I INTERFERON SIGNALINGBrian Daniels - David Holman - Lillian Cruz-orengo - Harsha Jujjavarapu - Robyn Klein Washington University School Of Medicine, University, St. Louis, United States

111 - B7-HOMOLOGUE 1 INHIBITS T CELL-MEDIATED BLOOD-BRAIN BARRIER DISRUPTION AND REGIONAL ENCEPHALITOGENICITY IN A SPONTANEOUS MODEL OF CNS AUTOIMMUNITYIvan Kuzmanov - Vilmos Posevitz - Stephanie Hucke - Daria Chudyka - Angela Dreykluft - Luisa Klotz - Heinz Wiendl Department Of Neurology, University Hospital Münster, Münster, Germany

98 - ALCAM REGULATES BBB INTEGRITY AND NEUROINFLAMMATIONMarc-andré Lécuyer - Lyne Bourbonnière - Sandra Larouche - Simone Terouz - Hania Kébir - Soufiane Ghannam Catherine Larochelle - Alexandre Prat Centre De Recherche Du Chum, University Of Montréal, Montréal, Canada

28 - ALPHA4BETA1 IS A MAJOR MOLECULAR CUE USED BY CYTOTOXIC CD8 T CELLS TO MIGRATE INTO THE CNSGuillaume Martin-blondel (1) - Béatrice Pignolet (1) - Claudia Blatti (2) - Therese Perinat (2) - Lidia Yshii (1) Christina Gebauer (1) - Britta Engelhardt (2) - Roland Liblau (1)

Inserm Umr 1043, Centre De Physiopathologie Toulouse-purpan, Toulouse University Hospital, Toulouse, France (1) - Theodor Kocher Institute, University Of Bern, Bern, Switzerland (2)



285 - ASTROCYTE-DERIVED RETINOIC ACID: A NOVEL REGULATOR OF BLOOD-BRAIN BARRIER FUNCTION DURING NEUROINFLAMMATION IN MULTIPLE SCLEROSIS.Mark Mizee (1) - Philip Nijland (1) - Susanne Van Der Pol (1) - Joost Drexhage (1) - Bert Van Het Hof (1) - Reina Mebius (2) Paul Van Der Valk (3) - Jack Van Horssen (1) - Arie Reijerkerk (4) - Elga De Vries (1)

Neuroscience Campus Amsterdam, Vu University Medical Center, Amsterdam, Netherlands (1) - Mcbi, Vu University Medical Center, Amsterdam, Netherlands (2) - Pathology Department, Vu University Medical Center, Amsterdam, Netherlands (3) - To-bbb, Technologies, Leiden, Netherlands (4)

500 - IMATINIB AMELIORATES NEUROINFLAMMATION IN A RAT MODEL OF MULTIPLE SCLEROSIS BY ENHANCING BLOOD-BRAIN BARRIER INTEGRITY AND BY MODULATING THE PERIPHERAL IMMUNE RESPONSE Milena Adzemovic (1) - Manuel Zeitelhofer (1) - Ulf Eriksson (1) - Tomas Olsson (2) - Ingrid Nilsson (1)

Department Of Medical Biochemistry And Biophysics, Vascular Biology Division, Karolinska Institute, Stockholm, Sweden (1) - Center Of Molecular Medicine, Karolinska Institute, Stockholm, Sweden (2)

151 - NOVEL INSIGHTS INTO CELL-CELL INTERACTIONS AT THE BLOOD-BRAIN BARRIER REVEALED BY A FULLY-HUMAN IN VITRO MODEL INCORPORATING FLOWBirgit Obermeier (1) - Bryan L. Benson (2) - Haiyan Lu (1) - Grahame Kidd (1) - Simona Spampinato (1) - Yukio Takeshita (3) Yasutero Sano (3) - Takashi Kanda (3) - Richard M. Ransohoff (1)

Neuroinflammation Research Center, Department Of Neurosciences, Lerner Research Institute, Cleveland Clinic, Cleveland, United States (1) - Department Of Pathology, Case Western Reserve University School Of Medicine, Cleveland, United States (2) - Department Of Neurology And Clinical Neurosciences, Yamaguchi University Graduate School Of Medicine, Yamaguchi, Japan (3)

494 - ALPHA 4 BETA 7 INTEGRIN SELECTIVELY CONTROLS TH17 CELL RECRUITMENT TO THE CENTRAL NERVOUS SYSTEM DURING EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITISBarbara Rossi - Silvia Dusi - Antonella Amoruso - Gabriela Constantin Department Of Pathology And Diagnostics, University Of Verona, Verona, Italy

270 - IDENTIFICATION OF SUBSET SPECIFIC MECHANISMS FOR CD8+ VERSUS CD4+ TEM CELLS MEDIATING THEIR MIGRATION ACROSS THE INFLAMED BLOOD-BRAIN BARRIER UNDER PHYSIOLOGICAL FLOW IN VITROHenriette Rudolph (1) - Claudia Blatti (1) - Horst Schroten (2) - Ruth Lyck (1) - Britta Engelhardt (1)

Theodor Kocher Institute, University Of Bern, Bern, Switzerland (1) - Pediatric Infectious Diseases, University Children’s Hospital Mannheim, Mannheim, Germany (2)

137 - ANALYSIS OF FACTORS REGULATING THE EXPRESSION OF AQP4 IN HUMAN ASTROCYTEYasuteru Sano - Mariko Oishi - Hiroyo Haruki - Fumitaka Shimizu - Masaaki Abe - Takashi Kanda Department Of Neurology And Clinical Neuroscience, Yamaguchi University Graduate School Of Medicine, Ube, Japan

85 - REGULATION OF LYMPHOCYTE ADHESION AND MIGRATION INTO THE CNS BY PHOSPHOLIPASE D1 IN AUTOIMMUNE NEUROINFLAMMATIONBittner Stefan Department Of Neurology, University Of Muenster, Münster, Germany

440 - INVOLVEMENT OF JUNCTIONAL ADHESION MOLECULES IN THE PATHOGENESIS OF EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITISJulia Michel (1) - Silvia M. Tietz (1) - Rémy Boscacci (1) - Claudia Blatti (1) - Ruth Lyck (1) - Israel F. Charo (2) Richard M. Ransohoff (3) - Elisabetta Dejana (4) - Urban Deutsch (1) - Britta Engelhardt (1)

Theodor Kocher Institute, University Of Bern, Bern, Switzerland (1) - Gladstone Institute Of Cardiovascular Disease, University Of California San Francisco, San Francisco, United States (2) - Lerner Research Institute, Cleveland Clinic, Cleveland, United States (3) Ifom-ieo Campus, Research Institute, Milan, Italy (4)

638 - EARLY BREAKDOWN OF THE BLOOD-BRAIN BARRIER IN A MODEL OF NEUROMYELITIS OPTICAAnne Winkler (1) - Claudia Wrzos (1) - Wolfgang Brück (1) - Jeffrey L. Bennett (2) - Stefan Nessler (1) - Christine Stadelmann (1)

Institute Of Neuropathology, University Medical Center Göttingen, Göttingen, Germany (1) - Departments Of Neurology And Ophthalomology, University Of Denver, Colorado, United States (2)

25

Scientific Program

COFFEE BREAK & POSTER SESSION | CLINICAL RESEARCH15:15 - 16:45 POSTERHALL (RHEINFOYER)

314 - STUDY ON ASSAY SYSTEM FOR ANTI-SYNAPSIN 1A ANTIBODYAtsuro Chiba - Ayumi Uchibori - Tomoko Kato School Of Medicine, Kyorin University, Tokyo, Japan

353 - JUVENILE MYASTHENIA GRAVIS: COMPARISON OF PRE AND POSTPUBERTAL CASESOzgul Ekmekci - Hatice Karasoy - Ayse Nur Yuceyar Ege University, Neurology Department, Ege University, Neurology Department, Izmir, Turkey

123 - A RETROSPECTIVE STUDY OF THE ASSOCIATION BETWEEN LEUCOCYTES, IGG-INDEX, OLIGOCLONALE BANDS AND AGE IN DEMYELINATING DISEASE.Jette L Frederiksen - Mie Bülow Clinic Of Multiple Sclerosis And Optic Neuritis, Department Of Neurology, Glostrup Hospital, University Of Copenhagen, Glostrup, Denmark

155 - RITUXIMAB AMELIORATES ANTI-N-METHYL-D-ASPARTATE RECEPTOR ENCEPHALITIS BY REMOVING SHORT-LIVED PLASMABLASTSYasuo Hachiya (1) - Akinori Uruha (2) - Emi Kasai-yoshida (1) - Konomi Shimoda (3) - Ikuko Shirai (1) - Satoko Kumada (1) Eiji Kurihara (1) - Kotoko Suzuki (4) - Atsuko Ohba (4) - Shin-ichiro Hamano (4) - Hiroshi Sakuma (5)

Department Of Neuropediatrics, Tokyo Metropolitan Neurological Hospital, Tokyo, Japan (1) - Department Of Clinical Development, Translational Medical Center, National Center Of Neurology And Psychiatry, Tokyo, Japan (2) - Department Of Pediatrics, Graduate School Of Medicine, University Of Tokyo, Tokyo, Japan (3) - Division Of Neurology, Saitama Children’s Medical Center, Saitama, Japan (4) Department Of Brain Development And Neural Regeneration, Tokyo Metropolitan Institute Of Medical Science, Tokyo, Japan (5)

260 - NEUROMYELITIS OPTICA IN AN ASIAN POPULATION: CLINICAL FEATURES AND DISEASE COURSEJyh Yung Hor (1) - Thien Thien Lim (1) - Yuen Kang Chia (1) - Han Bing Chow (2) - Yee Ming Ching (3) - Masita Arip (3) Gaik Bee Eow (1) - Md Hanip Rafia (4)

Department Of Neurology, Penang General Hospital, Penang, Malaysia (1) - Department Of Medicine, Penang Medical College, Penang, Malaysia (2) - Autoimmune Unit, Allergy And Immunology Research Centre, Institute For Medical Research, Kuala Lumpur, Malaysia (3) - Department Of Neurology, Kuala Lumpur General Hospital, Kuala Lumpur, Malaysia (4)

352 - DYNAMIC CHANGES OF PROINFLAMMATORY BIOMARKERS IN THE ACUTE PHASE OF ISCHEMIC STROKE PREDICT OUTCOME AND CORRELATE WITH CHANGES IN THE L-ARGININE PATHWAYZsolt Illes (1) - Tihamer Molnar (2) - Viktoria Papp (3) - Gergely Feher (3) - Norbert Kovacs (3) - Laszlo Szapary (3) Birgit Debradant (4) - Gabriella Pusch (3)

Institute Of Clinical Research And Department Of Neurology, University Of Southern Denmark, Odense, Denmark (1) - Department Of Anaesthesiology And Intensive Care, University Of Pecs, Pecs, Hungary (2) - Department Of Neurology, University Of Pecs, Pecs, Hungary (3) - Epidemiology And Biostatistics, Institute Of Public Health,, University Of Southern Denmark, Odense, Denmark (4)

133 - ABNORMALITIES IN T CELL DIFFERENTIATION IN PATIENTS WITH THE LAMBERT-EATON MYASTHENIC SYNDROMEAlexander F Lipka (1) - Maarten J.d. Van Tol (2) - Jacqueline L.m. Waaijer (2) - Cornelia M. Jol-van Der Zijde (2) Jan J.g.m. Verschuuren (1)

Dept. Of Neurology, Leiden University Medical Center, Leiden, Netherlands (1) - Dept. Of Pediatrics, Leiden University Medical Center, Leiden, Netherlands (2)

423 - INVOLVEMENT OF SEMA4A IN MULTIPLE SCLEROSIS AND NEUROMYELITIS OPTICATatsusada Okuno (1) - Toru Koda (1) - Katsuichi Miyamoto (2) - Kazushiro Takata (1) - Josephe A. Honorat (1) Susumu Kusunoki (2) - Atsushi Kumanogoh (3) - Yuji Nakatsuji (1) - Hideki Mochizuki (1)

Departments Of Neurology, Osaka University Graduate School Of Medicine, Osaka, Japan (1) - Departments Of Neurology, Kinki University, Osaka, Japan (2) - Ifrec, Osaka University, Osaka, Japan (3)

503 - CYTOKINE LEVELS IN NON-ONCOLOGIC NEUROPATHIC PAIN PATIENTS UNDER INTRATHECAL OR ORAL PROLONGED MORPHINE TREATMENTChristiane Pellegrino Rosa University Of Sao Paulo, School Of Medicine Of Medical School Of University Of Sao Paulo, Sao Paulo, Brazil



344 - SARCOIDOSIS ASSOCIATED T-CELL DYSREGULATION PREDISPOSES TO PROGRESSIVE MULTIFOKAL LEUKENCEPHALOPATHYSina C. Rosenkranz (1) - Vivian Thom (2) - Anne Willing (1) - Manuela Kolster (3) - Eva Tolosa (3) - Manuel A. Friese (1)

Institute Of Neuroimmunology And Multiple Sclerosis (inims), Centre For Molecular Neurobiology (zmnh), University Medical Centre Hamburg-eppendorf, Hamburg, Germany (1) - Department Of Neurology, University Medical Centre Hamburg-eppendorf, Hamburg, Germany (2) - Department Of Immunology, University Medical Centre Hamburg-eppendorf, Hamburg, Germany (3)

58 - MYASTHENIA GRAVIS ASSOCIATED WITH THYMOMA IN A PATIENT WITH CHRNE CONGENITAL MYASTHENIC SYNDROMEErnestina Santos (1) - Isabel Moreira (2) - Maria Isabel Leite (3) - Jose Lopes Lima (2)

Neurology Department, Hospital Santo Antonio , Instituto De Ciencias Biomedicas Abel Salazar, Universidade Do Porto, Porto, Portugal (1) - Neurology Department, Hospital Santo Antonio, Porto, Portugal (2) - Department Of Clinical Neurology, Nuffield Department Of Clinical Neurosciences, John Radcliffe Hospital, University Of Oxford, Oxford, United Kingdom (3)

32 - EOSINOPHILIC CNS VASCULITIS CAN MIMIC DEMYELINATING DISEASE OF THE BRAIN AND SPINAL CORD Raphael Schneider - Jenny Tsai - Daniel Selchen - David Munoz University Of Toronto, St. Michael’s Hospital, Toronto, Canada

55 - THE COMPARISON OF MESENCHYMAL STEM CELL WITH MITOXANTRONE IN TREATMENT OF PATIENTS WITH MULTIPLE SCLEROSIS. Saeed Shahbeigi (1) - Mandana Mohyeddin Bonab (1) - Behrouz Nikbin (1) - Yadollah Shakiba (1) - Ghazal Jalilzadeh (2) - Abbas Najari (3) - Leila Chegini (4) - Torach Orang (5) - Shaghayegh Ranjbar (6) - Samaneh Sheikhi Kouhsar (1) - Foroogh Nejatollahi (7) - Masoud Yousefvand (8) - Gholamreza Bakhshandepour (9) - Saeed Esmaeil Soofian (10)

Immunology Department, Tehran, Tehran, Iran (1) - Jondishapour Neurology Clinic, Jondishapour Neurology Clinic, Tehran, (2) - Ministry Of Health, Ministry Of Health, Tehran, (3) - Iran Medical University, Iran Medical University, Tehran, Iran (4) - Iran Medical University, Iran Medical University, Tehran, Iran (5) - Shahid Beheshti Medical University, Shahid Beheshti Medical University, Tehran, Iran (6) - Shiraz Medical University, Shiraz Medical University, Shiraz, Iran (7) - Ministry Of Health, Ministry Of Health, Tehran, Iran (8) - Paytakht Mri Center, Paytakht Mri Center, Tehran, Iran (9) - Iran Medical University, Iran Medical University, Tehran, Iran (10)

252 - UNALTERED FREQUENCY AND FUNCTIONALITY OF CD56BRIGHT AND CD56DIM NATURAL KILLER CELLS IN UNTREATED RELAPSING-REMITTING MULTIPLE SCLEROSIS PATIENTSSofia Sisay (1) - Alicia Rosello (1) - Korinna Henseleit (1) - Matt Tan (1) - Monica Marta-caldo (1) - Priya Dua (1) Gary Warnes (1) - Jacqueline Palace (2) - Gavin Giovannoni (1) - Ute-christiane Meier (1)

Centre Of Neuroscience And Trauma, Blizard Building, Barts And The London School Of Medicine And Dentistry, Queen Mary Univeristy, London, United Kingdom (1) - The Department Of Clinical Neurology, Oxford University Hospitals Nhs Trust, Oxford, Oxford University Hospital, Oxford, United Kingdom (2)

24 - ANTIPHOSPHOLIPID ANTIBODIES IN PATIENTS WITH MULTIPLE SCLEROSIS OR NEUROMYELITIS OPTICAKazuya Takahashi - Kiyonobu Komai - Chiho Ishida - Yuko Motozaki - Tokuhei Ikeda - Ichiro Nozaki Neurology, National Hospital Organization Iou Hospital, Kanazawa, Japan

320 - A STUDY ON THE MECHANISM OF ANTIGEN-ANTIBODY REACTION INCREASED BY GANGLIOSIDE-COMPLEX IN GUILLAIN-BARRÉ SYNDROME.Ayumi Uchibori - Atsuro Chiba School Of Medicine, Kyorin University, Tokyo, Japan

504 - TREATMENT RESISTANT AUTOIMMUNE AUTONOMIC GANGLIONITIS ASSOCIATED WITH INCREASED SERUM IMMUNOGLOBULIN LIGHT CHAINSAtay Vural (1) - Pelin Nar Senol (1) - Yahya Büyükasik (2) - Bülent Elibol (1) - Meryem Asli Tuncer (1)

Hacettepe University, Faculty Of Medicine, Department Of Neurology, Ankara, Turkey (1) - Hacettepe University, Faculty Of Medicine, Department Of Hematology, Ankara, Turkey (2)

618 - MEMANTINE THERAPY IN A PATIENT WITH SEVERE ANTI-N-METHYL-D-ASPARTATE RECEPTOR (NMDAR) ENCEPHALITISYi-chia Wei (1) - Ming-feng Liao (2) - Yih-ru Wu (2) - Chi-hung Liu (2) - Jainn-jim Lin (3)

Department Of Neurology, Chang Gung Memorial Hospital, Keelung, Taiwan, Province Of China (1) - Department Of Neurology, Linkou Medical Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan, Province Of China (2) - Division Of Pediatric Neurology, College Of Medicine, Chang Gung University, Taoyuan, Taiwan, Province Of China (3)

27

Scientific Program

17 - GUILLAIN-BARRÉ SYNDROME IN NORTHEAST CHINA: A RETROSPECTIVE ANALYSIS OF 516 CASESYing Wang - Guihong Li - Xinyu Li - Siyu Yang - Xiaoyi Gu - Mingyang Liu - Xiujuan Wu - Hongliang Zhang Neuroscience Center, Department Of Neurology, The First Hospital Of Jilin University, Changchun, China

22 - MORE SEVERE MANIFESTATIONS AND POORER SHORT-TERM PROGNOSIS OF GANGLIOSIDE-ASSOCIATED GUILLAIN-BARRÉ SYNDROME IN NORTHEAST CHINAHongliang Zhang (1) - Xiujuan Wu (1) - Wei Wu (2) - Zhengzheng Wang (1) - Donghui Shen (1) - Wei Pan (3) - Ying Wang (4) Linmin Wu (1) - Xiaokun Wu (1) - Jiachun Feng (1) - Kangding Liu (1) - Jie Zhu (1)

Neuroscience Center, Department Of Neurology, The First Hospital Of Jilin University, Changchun, China (1) - Department Of Neurosurgery, The First Hospital Of Jilin University, Changchun, China (2) - School Of Public Health, Jilin University, Changchun, China (3) - Norman Bethune Health Science Center, Jilin University, Changchun, China (4)

570 - TOXIC LEUKOENCEPHALOPATHY CAUSED BY MORANTEL: A CASE REPORTJing Bai - Shuai Yan - Xiujuan Wu - Hongliang Zhang Neuroscience Center, Department Of Neurology, The First Hospital Of Jilin University, Changchun, China

COFFEE BREAK & POSTER SESSION | INNATE IMMUNE SYSTEM 15:15 - 16:45 POSTERHALL (RHEINFOYER)

406 - INFLAMMASOME-MEDIATED ACTIVATION OF MICROGLIA DIFFERS IMPORTANTLY FROM THAT OF HEMATOPOIETIC MACROPHAGESSaskia Burm (1) - Ella Zuiderwijk-sick (1) - Anke’t Jong (1) - Céline Van Der Putten (1) - Jennifer Veth (1) - Ivanela Kondova (2) Jeffrey Bajramovic (1)

Biomedical Primate Research Centre, Alternatives Unit, Rijswijk, Netherlands (1) - Biomedical Primate Research Centre, Animal Science Department, Rijswijk, Netherlands (2)

408 - UTILIZING AN IN VITRO MICROGLIA-LIKE MODEL FOR EXPLORING GENETIC-DRIVEN INNATE IMMUNE SYSTEM DYSFUNCTION IN ALZHEIMER’S DISEASE.Katie Ryan (1) - Gail Chan (1) - Marta Olah (1) - Phoebe Winn (1) - Maria Cimpean (1) - Michael Frangieh (1) - Jaime Imitola (2) Wassim Elyaman (1) - Philip De Jager (1) - Elizabeth Bradshaw (1)

Brigham And Women’s Hospital, Harvard Medical School, Boston, United States (1) - Ohio State University, College Of Medicine, Columbus, United States (2)

608 - TARGETING MICROGLIA USING THE SPECIFIC TRANSCRIPTION FACTOR SALL1Anne Buttgereit (1) - Iva Lelios (1) - Xueyang Yu (1) - Ryuichi Nishinakamura (2) - Burkhard Becher (1) - Melanie Greter (1)

Institute Of Experimental Immunology, University Of Zurich, Zurich, Switzerland (1) - Institute Of Molecular Embryology And Genetics, Kumamoto University, Kumamoto, Japan (2)

244 - MYELOID-DERIVED SUPPRESSOR CELLS ARE KEY ELEMENTS FOR SYMPTOM RECOVERY IN A MURINE MODEL OF MULTIPLE SCLEROSISVerónica Moliné-velázquez - María Cristina Ortega - Virginia Vila-del Sol - Carolina Melero-jerez - Fernando De Castro Diego Clemente Grupo De Neurobiología Del Desarrollo-gnde, Hospital Nacional De Parapléjicos, Toledo, Spain

70 - EXPRESSION AND FUNCTIONAL ANALYSIS OF NUCLEIC ACID SENSORS IN CELLS OF THE CENTRAL NERVOUS SYSTEM.Donal Cox (1) - Glyn Williams (1) - Neil Kearney (1) - Andrew Bowie (1) - Marina Lynch (2) - Aisling Dunne (1)

School Of Biochemistry And Immunology, Trinity College Dublin, Dublin, Ireland (1) - Trinity College Institute Of Neuroscience, Trinity College Dublin, Dublin, Ireland (2)

469 - PLOVAMER ACETATE, BUT NOT GLATIRAMER ACETATE, INDUCES AN ANTI-INFLAMMATORY PHENOTYPE IN HUMAN MONOCYTESChui-se Tham (1) - Mike Webb (2) - Kenneth Crook (1) - Ursula Boschert (1)

Neurology Etip, Emd Serono Research & Development Institute, Billerica, United States (1) - Neurology Etip, Neuroimmunology Group, Emd Serono Research & Development Institute, Billerica, United States (2)



552 - MICROGLIA’S GENE EXPRESSION AT DIFFERENT STAGES OF EVOLUTION AND UNDER PATHOLOGICAL CONDITIONSFrancesca Grassivaro - Ramesh Menon - Cinthia Farina - Luca Muzio - Gianvito Martino Institute Of Experimental Neurology (inspe), University Vita Salute-san Raffaele, Milan, Italy

611 - INFLAMMATORY DYSREGULATION OF BLOOD MONOCYTES IN PARKINSON’S DISEASE PATIENTSVeselin Grozdanov (1) - Corinna Blierderhaeuser (1) - Valerie Roth (1) - Kathrin Fundel-clemens (2) - Lisa Zondler (1) Wolfgang P. Ruf (1) - Bastian Hengerer (2) - Jan Kassubek (1) - Albert C. Ludolph (1) - Jochen H. Weishaupt (1) Karin M. Danzer (1)

Neurology, Ulm University, Ulm, Germany (1) - Div. Research Germany, Boehringer Ingelheim Pharma Gmbh, Biberach/riss, Germany (2)

557 - INNATE MEMORY FORMATION IN NEUROIMMUNE INTERACTIONS IN PSORIASISTom Hartwig (1) - Stanislav Pantelyushin (2) - Paulina Kulig (1) - Burkhard Becher (1)

Institute Of Experimental Immunology, University Of Zurich, Zurich, Switzerland (1) - Department Of Pathology, University Of Geneva, Geneva, Switzerland (2)

436 - FAAH INHIBITION MODULATES TLR3-INDUCED INFLAMMATORY RESPONSES IN THE PERIPHERY AND BRAIN: POSSIBLE ROLE FOR CB1 RECEPTORSRebecca HenryPhysiology, School Of Medicine And Ncbes Centre For Pain Research And Galway Neuroscience Centre, National University Of Ireland, Galway, Galway, Ireland

152 - NEUTROPHIL PROFILE IN MULTIPLE SCLEROSIS AND NEUROMYELITIS OPTICA.Laura Hertwig (1) - Silvina Romero (1) - Klarissa Stürner (2) - Nadja Borisow (3) - Florence Pache (3) - Janina Behrens (3) Jason Millward (1) - Klemens Ruprecht (4) - Carmen Infante Duarte (1) - Friedemann Paul (3)

Institute For Medical Immunology, Charité - University Medicine Berlin, Berlin, Germany (1) - Institute For Neuroimmunology And Clinical Ms Research, University Medical Center-eppendorf, Hamburg, Germany (2) - Neurocure Clinical Research Center Ncrc, Clinical Neuroimmunology, Charite - University Medicine Berlin, Berlin, Germany (3) - Clinical And Experimental Multiple Sclerosis Research Center, Charité - University Medicine Berlin, Berlin, Germany (4)

424 - ENHANCED INNATE IMMUNE ACTIVATION BY GUILLAIN-BARRÉ SYNDROME-ASSOCIATED CAMPYLOBACTER JEJUNI LIPO-OLIGOSACCHARIDESRuth Huizinga (1) - Wouter Van Rijs (2) - Jeffrey Bajramovic (3) - Astrid Heikema (4) - Jon Laman (1) - Janneke Samsom (5) Bart Jacobs (2)

Department Of Immunology, Erasmus Mc, University Medical Center, Rotterdam, Netherlands (1) - Department Of Immunology And Neurology, Erasmus Mc, University Medical Center, Rotterdam, Netherlands (2) - Unit Alternatives, Biomedical Primate Research Centre, Rijswijk, Netherlands (3) - Department Of Microbiology, Erasmus Mc, University Medical Center, Rotterdam, Netherlands (4) Division Gastroenterology And Nutrition, Department Of Paediatrics, Erasmus Mc, University Medical Center, Rotterdam, Netherlands (5)

213 - CHARACTERIZATION OF CD56BRIGHT NK CELLS IN DACLIZUMAB HYP-TREATED RRMS PATIENTSDavid J. Huss (1) - Maria F. Fragoso (1) - Patrick Cullen (2) - Norm Allaire (2) - Jason D. Fontenot (1)

Immunology Research, Biogen Idec, Cambridge, United States (1) - Genetics And Genomics, Biogen Idec, Cambridge, United States (2)

195 - INDUCTION OF TYPE I INTERFERON IN THE CENTRAL NERVOUS SYSTEM PLAYS A PROTECTIVE ROLE IN EAEReza M. H. Khorooshi (1) - Thomas Holm (2) - Carsten Tue Berg (1) - Marlene Mørch (1) - Ruthe Truong Dieu (2) Dina Dræby (1) - Siegfried Weiss (3) - Stefan Lienenklaus (3) - Trevor Owens (1)

Institute Of Molecular Medicine, University Of Southern Denmark, Odense, Denmark (1) - Department Of Biomedicine, Århus University, Århus, Denmark (2) - Helmholtz-zentrum Für Infektionsforschung Gmbh, Braunschweig, Braunschweig, Germany (3)

105 - EFFECTS OF SOLUBLE HELMINTH COMPONENTS ON HUMAN MONOCYTES AND MACROPHAGES IN NEUROINFLAMMATIONGijs Kooij - Elsenoor J. Klaver - Mendel Ottow - Lisa Laan - Priscilla Heijnen - Susanne Van Der Pol - Helga E. De Vries -Chriistine D. Dijkstra - Irma Van Die Vumc, Vu University Medical Center Amsterdam, Amsterdam, Netherlands

199 - UP-REGULATION OF NOD LIKE RECEPTORS-3 SIGNALING IN MULTIPLE SCLEROSIS DISEASEFrancesca La Rosa (1) - Federica Piancone (1) - Ivana Marventano (1) - Laura Mendozzi (1) - Domenico Caputo (1) Marco Rovaris (1) - Marina Saresella (1) - Mario Clerici (2)

Don C. Gnocchi Onlus Foundation, Irccs S.m.nascente - Via Capecelatro, 66, Milano, Italy (1) - University Of Milan, Milan, Italy, Don C. Gnocchi Onlus Foundation, Milano, Italy (2)

29

Scientific Program

97 - REGULATION OF AMYLOID BETA OLIGOMER PHAGOCYTOSIS BY M1 AND M2 MACROPHAGE POLARIZATIONHarald Lund - Xingmei Zhang - Robert Harris Department Of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden

587 - SHOULD RAPID DECREASE OF NK CELLS BE MARKER OF CONVERSION FROM CIS TO CDMS?Helena Mareckova (1) - Dana Horakova (2) - Lucia Skacikova (1) - Eva Havrdova (2)

Immunology And Microbiology, First Medical Faculty, Charles University, Prague, Czech Republic (1) - Neurology Clinic, Ms Centrum, First Medical Faculty, Charles University, Prague, Czech Republic (2)

628 - IL-27 ACTS ON DCS TO SUPPRESS CNS AUTOIMMUNITY BY INDUCING CD39 EXPRESSIONIvan Mascanfroni (1) - Ada Yeste (1) - Silvio Vieira (1) - Evans Burns (1) - Bonny Patel (1) - Ido Sloma (2) - Yan Wu (3) Lior Mayo (1) - Rotem Ben-hamo (2) - Sol Efroni (2) - Vijay Kuchroo (1) - Simon Robson (3) - Francisco Quintana (1)

Center For Neurologic Diseases, Brigham And Women’s Hospital/harvard Medical School, Boston, United States (1) - The Mina And Everard Goodman Faculty Of Life Sciences, Bar Iian University, Ramat Gan, Israel (2) - Division Of Gastroenterology And Hepatology, Beth Israel Deaconess Medical Center/harvard Medical School, Boston, United States (3)

145 - INNATE IMMUNE RESPONSES IN MS: A SYSTEMATIC MONOCYTE AND B CELL-BASED STUDYAmandine Mathias (1) - Guillaume Perriard (1) - Mathieu Canales (1) - Charlotte Soneson (2) - Mauro Delorenzi (2) Giuseppe Pantaleo (3) - Myriam Schluep (4) - Renaud Du Pasquier (1)

Laboratory Of Neuro-immunology, Neuroscience Research Center, Lausanne University Hospital (chuv), Lausannne, Switzerland (1) Swiss Institute Of Bioinformatics, University Of Lausanne, Lausanne, Switzerland (2) - Service Of Immunology, Department Of Medicine, Lausanne University Hospital (chuv), Lausanne, Switzerland (3) - Service Of Neurology, Department Of Clinical Neurosciences, Lausanne University Hospital (chuv), Lausanne, Switzerland (4)

309 - CELL DIFFERENTIATION MODULATES INTRACELLULAR ANTIVIRAL RESPONSES IN NEURONAL CELLSTomoh Matsumiya - Ryo Hayakari - Fei Xing - Hidemi Yoshida - Tadaatsu Imaizumi Department Of Vascular Biology, Institute Of Brain Science, Hirosaki University Graduate School Of Medicine, Hirosaki, Japan

248 - THE SEVERITY OF THE CLINICAL COURSE IN EAE MICE IS RELATED TO MYELOID-DERIVED SUPPRESSOR CELL ENRICHMENT IN BOTH THE SPLEEN AND THE SPINAL CORD Carolina Melero-jerez - Fernando De Castro - Diego Clemente Grupo De Neurobiología Del Desarrollo-gnde, Hospital Nacional De Parapléjicos, Toledo, Spain

585 - SIRTUIN-1 IS INVOLVED IN LIPOPOLYSACCHARIDE- AND INTERFERON BETA-MEDIATED INTERLEUKIN-10 REGULATION IN HUMAN MONOCYTESYusei Miyazaki (1) - Masaaki Niino (1) - Toshiyuki Fukazawa (2) - Eri Takahashi (1) - Takayuki Nonaka (3) - Ryutaro Ochi (3) Naoya Minami (3) - Naoto Fujiki (3) - Shizuki Doi (3) - Seiji Kikuchi (3)

Clinical Research, Hokkaido Medical Center, Sapporo, Japan (1) - Neurology, Sapporo Neurology Clinic, Sapporo, Japan (2) - Neurology, Hokkaido Medical Center, Sapporo, Japan (3)

72 - IDENTIFICATION OF P2Y12 AS A MEDIATOR OF MIGRATION AND INFLAMMATION IN HUMAN MICROGLIACraig Moore (1) - Ariel Ase (1) - Angham Kinsara (1) - Vijayraghava Rao (1) - Mackenzie Michell-robinson (1) Oleg Butovsky (2) - Samuel Ludwin (3) - Philippe Seguela (1) - Amit Bar-or (1) - Jack Antel (1)

Montreal Neurological Institute, Mcgill University, Montreal, Canada (1) - Center For Neurologic Diseases, Department Of Neurology, Brigham And Women’s Hospital, Harvard Medical School, Boston, United States (2) - Department Of Pathology And Molecular Medicine, Queens University, Kingston, Canada (3)

529 - INCREASED ADIPONECTIN LEVELS IN SERUM OF EARLY PEDIATRIC ONSET MS INDUCE PRO-INFLAMMATORY RESPONSES OF BOTH MYELOID CELLS AND T CELLS.Mukanthu Nyirenda (1) - Laurence Poliquin-lasnier (1) - Heather Hanwell (2) - Alexander Saveriano (1) - Ayal Rozenberg (1) - Rui Li (1) - Craig Moore (1) - Chahrazed Belabani (3) - Trina Johnson (3) - Julia O’mahony (2) - Ruth Ann Marrie (4) Shannon Dunn (5) - Brenda Banwell (6) - Amit Bar-or (1)

Neuroimmunology Unit, Montreal Neurological Institute, Mcgill University, Montreal, Canada (1) - Neuroscience And Mental Health, Hospital For The Sick Children Research Institute, Toronto, Canada (2) - Experimental Therapeutics Program, Montreal Neurological Institute, Mcgill University, Montreal, Canada (3) - Departments Of Internal Medicine And Community Health, University Of Manitoba, Manitoba, Canada (4) - University Health Network, Toronto General Hospital, Toronto, Canada (5) - Division Of Neurology, Children Hospital Of Philadelphia, Philadelphia, United States (6)



288 - DISPENSABLE ROLE FOR TLRS 2,3,4,7,9 IN THE MOUSE OF MULTIPLE SCLEROSISPushpalatha Palle - Prof.dr.thorsten BuchInstitute For Medical Microbiology, Immunology And Hygiene, Technische Universitat Of Munich, Munich, Germany

380 - MICROGLIA SHOW AN INTERMEDIATE ACTIVATION STATUS IN EARLY LESION FORMATION IN MULTIPLE SCLEROSISLaura Peferoen (1) - Daphne Vogel (1) - Kimberley Ummenthum (1) - Marjolein Breur (2) - Priscilla Heijnen (2) Wouter Gerritsen (1) - Paul Van Der Valk (1) - Christine Dijkstra (2) - Sandra Amor (1)

Pathology Department, Vu Medical Centre, Amsterdam, Netherlands (1) - Mcbi, Vu Medical Centre, Amsterdam, Netherlands (2)

215 - FORMYL PEPTIDE RECEPTORS FROM THE INNATE IMMUNE SYSTEM AND THE VOMERONASAL ORGAN RECOGNIZE PATHOGEN DERIVED PEPTIDESTimo Schumann - Bernd Bufe - Frank ZufallDepartment Of Physiology, Saarland University/medical School Homburg, Homburg, Germany

182 - REDUCED RELEASE OF NITRIC OXIDE AND DIFFERENT CYTOKINES/CHEMOKINES BY AGED MICROGLIAL CELLS UPON ACTIVATION OF TOLL-LIKE RECEPTORS 2 AND 4Sandra Schütze (1) - Annika Kaufmann (2) - Sandra Ribes (2) - Jörg Scheffel (2) - Sandra Redllich (2) Uwe-karsten Hanisch (2) - Wolfgang Brück (2) - Roland Nau (2)

Department Of Geriatrics, Agaplesion Diakonissen Krankenhaus, Frankfurt Am Main, Germany (1) - Institute Of Neuropathology, University Medical Center, Göttingen, Germany (2)

496 - ROLE OF TREM2 AND CD200R IN MODULATING MICROGLIAL RESPONSE IN ASTROCYTE TARGETED IL10TG MICE FOLLOWING PERFORANT PATHWAY TRANSECTIONKalpana Shrivastava (1) - Mireia Recasens (1) - Beatriz Almolda (1) - Iain Campbell (2) - Bernardo Castellano (1) Berta Gonzalez (1)

Unit Of Histology, Dept. Of Cell Biology, Physiology And Immunology. Institute Of Neuroscience., Autonomous University Of Barcelona, Barcelona, Spain (1) - School Of Molecular Biosciences, University Of Sydney, Nsw, Sydney, Australia (2)

308 - DENDRITIC CELLS ARE SPECIFICALLY AFFECTED BY DIFFERENT IMMUNOMODULATORY TREATMENT STRATEGIES IN MULTIPLE SCLEROSISKatja Thomas - Tony Sehr - Undine Hainke - Thorsten Schultheiß - Tjalf Ziemssen Department Of Neurology, Neuroimmunological Lab, University Hospital, Dresden, Germany

369 - INCREASED PREVALENCE OF LTI CELLS IN CSF OF PATIENTS WITH EARLY MSMatilda Degn (1) - Signe Modvig (1) - Beatrice D Andersen (2) - Charlotte M Bonefeld (2) - Jette L Frederiksen (1) Carsten Geisler (2) - Marina Rode Von Essen (3)

The Multiple Sclerosis Clinic, Glostrup Hospital, University Of Copenhagen, Glostrup, Denmark (1) - Institute For International Health, Immunology And Microbiology, University Of Copenhagen, Copenhagen, Denmark (2) - The Danish Multiple Sclerosis Center, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark (3)

412 - IGF1 PRODUCING CD11C+ MICROGLIA EMERGE DURING POSTNATAL NEURODEVELOPMENTAgnieszka Wlodarczyk (1) - Nellie Martin (2) - Trevor Owens (1)

Institute Of Molecular Medicine, University Of Southern Denmark, Odense, Denmark (1) - Clinical Institute, Odense University Hospital, Odense, Denmark (2)

317 - DOUBLE-STRANDED RNA INDUCES THE EXPRESSION OF TYPE I INTERFERON-STIMULATED GENES 54 AND 56 IN HUMAN ASTROCYTE CELL LINEFei Xing - Tomoh Matsumiya - Ryo Hayakari - Hidemi Yoshida - Tadaatsu Imaizumi Department Of Vascular Biology, Institute Of Brain Science, Hirosaki University Graduate School Of Medicine, Hirosaki, Japan

610 - MONOCYTE SUBTYPES IN ALSLisa Zondler - Kathrin Müller - Veselin Grozdanov - Corinna Bliederhäuser - Patrick Weydt - Albert C. Ludolph Karin Danzer - Jochen H. Weishaupt Neurology Department, Ulm University, Ulm, Germany

31

Scientific Program

COFFEE BREAK & POSTER SESSION | MODELS OF DISEASE 15:15 - 16:45 POSTERHALL (RHEINFOYER)

602 - SPHINGOSIN-1-PHOSPHATE-RECEPTOR MODULATION REDUCES HYPEROXIA MEDIATED BRAIN INJURYMeray Serdar (1) - Karina Kempe (1) - Katharina Lumpe (1) - Barbara S. Reinboth (1) - Xinlin Hou (1) - Ralf Herrmann (1) Marco Sifringer (2) - Ursula Felderhoff-müser (1) - Ivo Bendix (1)

Department Of Pediatrics 1 - Neonatology, University Hospital Essen, Essen, Germany (1) - Department Of Anesthesiology And Intensive Care Medicine, Charité-universitätsmedizin Berlin, Berlin, Germany (2)

79 - CENTRAL BUT NOT PERIPHERAL ADMINISTRATION OF XPRO1595 IS THERAPEUTIC FOLLOWING MODERATE SPINAL CORD INJURY IN MICE.Hans Novrup (1) - Valerie Bracchi-ricard (2) - Dite Ellman (1) - Jerome Ricard (3) - Anajana Jain (4) - Lise Lyck (1) David Szymkowski (5) - Kate Lambertsen (1) - John Bethea (3)

Institute Of Molecular Medicine, University Of Southern Denmark, Odense, Denmark (1) - Biology, Drexel University, Philadelphia, United States (2) - Biology Department, Drexel University, Philadelphia, United States (3) - The Miami Project To Cure Paralysis, University Of Miami, Miami, (4) - Xencor Inc, Xencor Inc, Monrovia, United States (5)

100 - CHARACTERIZATION OF THE HUMORAL IMMUNE RESPONSE IN A LEWIS RAT MODEL OF CIDPSusana Brun - Jérôme De Seze - Elisabeth Trifilieff Inserm U1119 - Biopathologie De La Myéline, Neuroprotection Et Stratégies Thérapeutiques, Université De Strasbourg, Strasbourg, France

60 - TREATMENT WITH FTY-720 REVERSES SOCIAL RECOGNITION DEFICITS WITHOUT AFFECTING CLINICAL SCORES OR IMPAIRED MOTOR PERFORMANCE IN EAE IN SJL MICENatasja M.w.j. De Bruin (1) - Katja Schmitz (2) - Irmgard Tegeder (2) - Sonja Talmon (1) - Holger Jordan (1) - Mike Schmidt (1) Annett Haeussler (2) - Gerd Geisslinger (2) - Michael J. Parnham (1)

Fraunhofer Institute For Molecular Biology And Applied Ecology (ime), Project Group Translational Medicine & Pharmacology (tmp), Frankfurt Am Main, Germany (1) - Institute Of Clinical Pharmacology, Johann Wolfgang Goethe-university, Frankfurt Am Main, Germany (2)

577 - CNS TLR2 MEDIATES INNATE NEUROINFLAMMATION BUT NOT AUTOIMMUNE PATHOGENESIS AND DEMYELINATIONNina Fainstein (1) - Avital Luz (2) - Ofira Einstein (2) - Tamir Ben-hur (1)

Department Of Neurology, Hadassah Hebrew University Medical Center, Jerusalem, Israel (1) - Physiotherapy Department, Faculty Of Health Sciences, Ariel University Center Of Samaria, Israel, Ariel, Israel (2)

38 - THE EXPERIMENTAL ANTIPHOSPHOLIPID SYNDROME: AN INVALUABLE TOOL TO STUDY AUTOIMMUNITY-INDUCED NEURODEGENERATIONKatrin Frauenknecht (1) - Aviva Katzav (2) - Ronen Weiss (2) - Avishag Sabag (2) - Susanne Otten (1) - Joab Chapman (2) Clemens Sommer (1)

Department Of Neuropathology, University Medical Center Of The Johannes Gutenberg University Mainz, Mainz, Germany (1) Department Of Neurology, Chaim Sheba Medical Center, Sackler Faculty Of Medicine, Tel Aviv University, Tel Aviv, Israel (2)

108 - THE EFFECTS OF CILOSTAZOL ON EXPERIMENTAL AUTOIMMUNE NEURITIS IN LEWIS RATSWataru Hagiwara - Masashi Inoue - Shingo Konno - Toshiki Fujioka Division Of Neurology, Department Of Internal Medcine, Toho University Oohashi Medical Centre, Tokyo, Japan

373 - HEMATOMA CLEARANCE AND FUNCTIONAL RECOVERY AFTER INTRACEREBRAL HEMORRHAGE REQUIRE RECRUITED MONOCYTESMatthew D. Hammond (1) - Youxi Ai (1) - Lauren H. Sansing (2)

Department Of Neuroscience, University Of Connecticut Health Center, Farmington, Connecticut, United States (1) - Department Of Neurology, Yale School Of Medicine, New Haven, Connecticut, United States (2)

399 - TREATMENT WITH ANTI-MOUSE CD52 ANTIBODY IS ASSOCIATED WITH PRESERVATION OF MYELIN AND MAINTENANCE OF AXONAL CONDUCTION IN THE MOG-INDUCED EAE MOUSE MODELJianhua Huang - Petti Pang - Nilesh Pande - Michael J Turner - Michael J Lamorte - Nathalie Chretien - Carrie Garron Bruce L Roberts - Johanne M Kaplan - William M SidersNeuroimmunology Research, Genzyme, A Sanofi Company, Framingham, Ma, United States



29 - LATENT VIRAL INFECTION OF THE CENTRAL NERVOUS SYSTEM AND THE INSIDE-OUT AND OUTSIDE-IN HYPOTHESES OF MULTIPLE SCLEROSISLorne Kastrukoff (1) - Allan Lau (1) - Eva Thomas (2)

Department Of Medicine, University Of British Columbia, Vancouver, Canada (1) - Department Of Pathology, British Columbia’s Children’s Hospital, Vancouver, Canada (2)

533 - ANGIOTENSIN-(1-7) INHIBITS NF-KAPPA B IN GLIA CELLS OF ALS MODEL MICEKiyokazu Kawabe - Osamu Kano - Masaru Yanagihashi - Ken Ikeda - Yasuo Iwasaki Department Of Neurology, Toho University Omori Medical Centre, Tokyo, Japan

625 - DEVELOPMENT AND CHARACTERIZATION OF A NOVEL MOUSE MODEL OF RASMUSSEN’S ENCEPHALITISFrançois Fontaine (1) - Hania Kebir (2) - Nathalie Sanon (1) - Ciprian Bosoi (1) - Lyne Bourbonnière (2) - Simone Terouz (2) Cecile Ciuta (3) - Gregory L. Holmes (4) - Howard Goodkin (5) - John Myrtinger (5) - Mary Connolly (6) - Lionel Carmant (1) Alexandre Prat (2) - Elie Haddad (7)

Research Center, Centre Hospitalier Universitaire Sainte-justine, Department Of Pediatrics, Université De Montréal, Montreal, Canada (1) Centre De Recherche Du Centre Hospitalier De L’université De Montréal, Université De Montréal, Montreal, Canada (2) - Centre Hospitalier Universitaire De Sherbrooke, Department Of Pediatrics, Université De Sherbrooke, Sherbrooke, Canada (3) - Dartmouth- Hitchcock Medical Center Children’s Hospital, Department Of Neurology And Pediatrics, Dartmouth University, Manchester, United States (4) - Fountain Research Park, Department Of Pediatrics, University Of Virginia, Charlottesville, United States (5) - B.c. Children’s Hospital, Department Of Pediatrics, University Of British Columbia, Vancouver, Canada (6) - Department Of Pediatrics, Université De Montréal, Montreal, Canada (7)

639 - A NEW MOUSE MODEL OF INFLAMMATORY CORTICAL DEMYELINATIONNielsen Lagumersindez Denis - Claudia Wrzos - Wolfgang Brück - Christine Stadelmann - Stefan Nessler Institute Of Neuropathology, University Medical Centre Göttingen (umg), Göttingen, Germany

636 - HUMAN N-METHYL-D-ASPARTATE RECEPTOR ANTIBODIES ALTER MEMORY AND BEHAVIOR IN A PASSIVE VENTRICULAR MURINE INFUSION MODELFrank Leypoldt (1) - Jesus Planaguma (1) - Francesco Mannara (1) - Javier Gutierrez Cuesta (2) - Elena Martin-garcia (2) - Esther Aguilar (1) - Ankit Jain (3) - Maarten J. Titulaer (4) - Rita Balice-gordon (3) - Francesc Graus (1) - Rafael Maldonado (2) - Josep Dalmau (1)

Idibaps, Neurology, Hospital Clinic, Barcelona, Spain (1) - Laboratori De Neurofarmacología, Universitat Pompeu Fabra, Barcelona, Spain (2) - University Of Pennsylvania, Department Of Neuroscience, Philadelphia, United States (3) - Department Of Neurology, Erasmus Medical Center, Rotterdam, Netherlands (4)

445 - PHAGOCYTOSIS OF ABETA BY INFILTRATING MYELOID CELLS IN A MOUSE MODEL OF ALZHEIMER’S DISEASELuisa Möhle (1) - Andreas Müller (2) - Inna N. Lavrik (3) - Jens Pahnke (4) - Ildiko R. Dunay (1)

Institute Of Medical Microbiology, Otto-von-guericke University, Magdeburg, Germany (1) - Institute For Molecular And Clinical Immunology, Otto-von-guericke University, Magdeburg, Germany (2) - Institute Of Experimental Internal Medicine, Otto-von-guericke University, Magdeburg, Germany (3) - Neurodegeneration Research Lab (nrl), Department Of Neurology, Otto-von-guericke University, Magdeburg, Germany (4)

588 - MODELING BRAIN DISEASES WITH DIRECT INDUCTION TECHNOLOGY OF RAMIFIED MICROGLIA-LIKE (IMG) CELLS FROM HUMAN MONOCYTESMasahiro Ohgidani - Takahiro A. Kato - Shigenobu Kanba Department Of Neuropsychiatry, Graduate School Of Medical Sciences, Kyushu University, Fukuoka, Japan

206 - MODELING CNS PHENOTYPES OF X-LINKED CMT BY LPS-INDUCED INFLAMMATIONMargarita Olympiou The Cyprus Institute Of Neurology And Genetics, Cyprus School Of Molecular Medicine, Nicosia, Cyprus

347 - THE GUT MICROFLORA DETERMINES PATHOGENICITY IN TH17-MEDIATED CNS AUTOIMMUNITYTommy Regen (1) - Nir Yogev (1) - Jula Huppert (1) - Sandrine Isaac (2) - Immo Prinz (3) - Carles Ubeda (2) - Ari Waisman (1)

Institute For Molecular Medicine, University Medical Center, Mainz, Germany (1) - Department Of Genomics And Health, Center For Advanced Research In Public Health, Valencia, Spain (2) - Institute Of Immunology, Hannover Medical School, Hannover, Germany (3)

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Scientific Program

446 - EFFICACY AND MECHANISMS OF A COMBINATION THERAPY WITH DIMETHYL FUMARATE AND COPOLYMER-1 IN AUTOIMMUNITY OF THE CENTRAL NERVOUS SYSTEMChristiane Reick (1) - Gisa Ellrichmann (1) - Carsten Saft (1) - Ralf Linker (2) - Ralf Gold (1)

Department Of Neurology, St. Josefs Hospital, Clinic Of The Ruhr University Bochum, Bochum, Germany (1) - Department Of Neurology, University Hospital Erlangen, Erlangen, Germany (2)

141 - ROLE OF ALPHA-METYLACYL-COA RACEMASE IN IMMUNE CELLS DURING THE DEVELOPMENT OF EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITISNadja Tafferner (1) - Julia Männich (2) - Max Eberle (2) - Nerea Ferreiros (2) - Natasja Debruin (1) - Gerd Geisslinger (1) Michael J. Parnham (1) - Susanne Schiffmann (1)

Fraunhofer Institute For Molecular Biology And Applied Ecology (ime), Project Group Translational Medicine & Pharmacology (tmp), Institute Of Clinical Pharmacology, Johann Wolfgang Goethe-university, Frankfurt, Germany (1) - Institute Of Clinical Pharmacology, Johann Wolfgang Goethe-university, Frankfurt, Germany (2)

400 - THE ANTI-INFLAMMATORY ACTIONS OF NORADRENERGIC AGENTS AS A TARGET TO PREVENT NEURODEGENERATION IN PARKINSON’S DISEASEJustin Yssel - Thomas Connor - Andrew Harkin Trinity College Institute Of Neuroscience, Trinity College Dublin, Dublin, Ireland

COFFEE BREAK & POSTER SESSION | OMICS 15:15 - 16:45 POSTERHALL (RHEINFOYER)

35 - GENOME-WIDE RNA EXPRESSION PROFILING IN HUMAN GREY AND WHITE MATTER TISSUE REVEALS A ROLE FOR PSA-NCAM DYSREGULATION IN MS PATHOGENESISIlona Bruinsma (1) - Vivian Eijsink (2) - Evert-jan Kooi (3) - Sergio Baranzini (4) - Xuhuai Ji (5) - Robert Axtell (5) - May Han (5) Hedwich Kuipers (5) - Raymond Sobel (5) - Chris Polman (3) - Jeroen Geurts (3) - Gerard Martens (2) - Geert Poelmans (1) Lawrence Steinman (5) - Brigit De Jong (1)

Radboud University Medical Center, Hospital, Nijmegen, Netherlands (1) - Radboud University, University, Nijmegen, Netherlands (2) Vu University Medical Center, Hospital, Amsterdam, Netherlands (3) - Ucsf, University, San Francisco, United States (4) - Stanford University, University, Stanford, United States (5)

232 - CEREBROSPINAL FLUID PROTEOMICS SIGNATURE OF PROGRESSIVE MULTIFOCAL LEUKOENCELOPHATHY IN NATALIZUMAB-TREATED MS PATIENTSWolfgang Faigle (1) - Ilijas Jelcic (1) - Bernd Roschitzki (2) - Roland Martin (1)

Neuroimmunology And Multiple Sclerosis Research Department Of Neurology, University Hospital Zurich, Zurich, Switzerland (1) Functional Genomic Center Zurichl, University Of Zurich, Zurich, Switzerland (2)

COFFEE BREAK & POSTER SESSION | PATHOLOGY 15:15 - 16:45 POSTERHALL (RHEINFOYER)

128 - STRUCTURAL ABNORMALITIES OF MYELIN AND AXON IN MURINE MODELS OF CNS DEMYELINATING DISEASE.Yoshio Bando - Shigetaka Yoshida Dept. Of Functional Anatomy And Neuroscience, Asahikawa Medical University, Asahikawa, Japan

COFFEE BREAK & POSTER SESSION | PSYCHOIMMUNOMODULATION 15:15 - 16:45 POSTERHALL (RHEINFOYER)

217 - PRE-EXPOSURE TO THE UNCONDITIONED OR THE CONDITIONED STIMULUS DIFFERENTIALLY AFFECT LEARNED IMMUNOSUPPRESSION IN RATSKatharina Bösche - Martin Hadamitzky - Laura Lückemann - Harald Engler - Manfred Schedlowski Institute Of Medical Psychology And Behavioral Immunobiology, University Hospital, University Duisburg-essen, Essen, Germany



118 - MICROGLIA ARE POLARIZED TO M1 TYPE IN HIGH-ANXIETY INBRED MICE IN RESPONSE TO LIPOPOLYSACCHARIDE CHALLENGEZhilin Li - Li Ma - Natalia Kulesskaya - Vootele Võikar - Li Tian Neuroscience Center, University Of Helsinki, Helsinki, Finland

631 - RELIGIOUS THOUGHTS AND PSYCHOLOGICAL HEALTH IN THE STUDENTS OF BROOKLYN NEW YORK USA: AN ECOLOGICAL MOMENTARY ASSESSMENT INVESTIGATIONMd. Ariful Haque Mollik Peoples Integrated Alliance, University Of Development Alternative, Bogra, Bangladesh

627 - ABSENCE OF IFN-GAMMA LEADS TO AN ENHANCED COGNITIVE PHENOTYPESusana Monteiro - Filipa Ferreira - Vitor Pinto - Susana Roque - Daniela Calçada - Mónica Morais Margarida Correia-neves - João José Cerqueira Life And Health Sciences Research Institute (icvs), School Of Health Sciences - Universidade Do Minho, Braga, Portugal

315 - STRESS ALTERS CYTOKINE PROFILE OF THE SKIN: PROSPECTIVE LINKS TO NNCS REGULATIONFrank Risto Rommel (1) - Badrinarayanan Raghavan (1) - Susanne Tumala (1) - Uwe Gieler (2) Eva Milena Johanne Peters (3)

Psychoneuroimmunology Laboratory, Department Of Psychosomatic Medicine And Psychotherapy, Justus Liebig University, Giessen, Germany (1) - Department Of Dermatology, Justus Liebig University, Giessen, Germany (2) - Psychoneuroimmunology Laboratory, Department Of Psychosomatic Medicine And Psychotherapy & Center For Internal Medicine And Dermatology, Justus Liebig University & Charité-university Medicine, Giessen & Berlin, Germany (3)

492 - NOCTURNAL SHIFT WORK ALTERS SLEEP PATTERN OF ADULTSFrancieli Silva Ruiz - Iona Z Zimberg - Marcus Mvl Santos - Ulisses A Andrade - Lia Ra Bittencourt - Sergio Tufik Marco Tulio Mello Universidade Federal De Sao Paulo, Universidade Federal De Sao Paulo, Sao Paulo, Brazil

374 - EXPERIMENTAL HUMAN ENDOTOXEMIA: A MODEL TO DISENTANGLE THE IMMUNE-TO-BRAIN COMMUNICATIONManfred Schedlowski - Jan-sebastian Grigoleit - Harald Engler Institute Of Medical Psychology And Behavioral Immunobiology, University Hospital Essen, Essen, Germany

372 - TEACH THE T CELLS: HOW LEARNING CAN SHAPE IMMUNITYManfred Schedlowski - Katharina Bösche - Laura Lückemann - Harald Engler - Martin Hadamitzky Institute Of Medical Psychology And Behavioral Immunobiology, University Hospital Essen, Essen, Germany

TECHNOLOGY TALK UBIQUITIN 16:45 - 17:30 PLENARY ROOM (KONGRESS SAAL)

Chair: Scott Zamvil

16:45 THE ROLE OF UBIQUITIN NETWORKS IN INFLAMMATION Ivan Dikic

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Scientific Program

PATHOGENIC T-CELLS 08:15 - 09:30 PLENARY ROOM (KONGRESS SAAL)

Chairs: Roberto Furlan, Roland Liblau

08:15 HETEROGENEITY AND REDUDANCY IN AUTOIMMUNE PATHOGENESIS: IS THE ATTEMPT TO IDENTIFY A FACTOR UNIVERSALLY REQUIRED FOR T CELL ENCEPHALITOGENESITY A QUIXOTIC QUEST? Benjamin Segal

08:53 CLASS AND SPECIFICITY OF THE HUMAN T CELL RESPONSE IN HEALTH AND DISEASE Federica Sallusto


NEUROIMMUNOLOGY OF BRAIN TUMORS 10:00 - 11:45 ROOM A (KONGRESS SAAL)

Chairs: Heinz Wiendl, Luca Battistini

10:00 TARGETING A DRIVER MUTATION GLIOMA WITH A PEPTIDE VACCINE AGAINST IDH1R132H Michael Platten

10:23 PERSONALIZED IMMUNOTHERAPY FOR BRAIN TUMORS Wolfgang Wick

10:45 EPIDERMAL GROWTH FACTOR VARIANT III-DIRECTED IMMUNOTHERAPY OF GLIOBLASTOMA Michael Weller

11:08 MECHANISMS OF TUMOR INVASION OF EVASIVE RESITANCE TO ANTI-AGIOGENESIS THERAPY Amparo Acker-Palmer 11:30 57 - A MOUSE MODEL FOR PARANEOPLASTIC NEUROLOGICAL SYNDROME: FROM ANTI-TUMOR IMMUNITY TO AUTOIMMUNITY TARGETING NEURONS Christina Gebauer (1) - Beatrice Pignolet (1) - Lidia Yshii (1) - Guillaume Martin-blondel (1) - Britta Engelhardt (2) - David Brassat (1) - Roland Liblau (1) Cptp, Inserm U1043, Hopital Purpan/université Paul Sabatier, Toulouse, France (1) - Theodor Kocher Institut, University Of Bern, Bern, Switzerland (2)

EMERGING TOPICS IN NEUROIMMUNOLOGY 10:00 - 11:45 ROOM B (GUTENBERGSAAL 1)

Chairs: Francesca Aloisi, Bert ‘t Hart

10:00 NON-CODING RNA IN REGULATION OF AUTOIMMUNE DEMYELINATION Marcin P. Mycko

10:23 NEUROIMMUNOLOGY OF REMYELINATION V Wee Yong

10:45 MOLECULAR AND CELLULAR MECHANISMS OF IMMUNE MODULATION BY MS THERAPAUTICS Scott Zamvil

DAY 3 Tuesday | November 11th 2014

36 Day 3 | Tuesday - November 11th


11:08 HARVESTING FROM THE GUT MICROBIOME: THE ROLE IN REGULATING CNS DEMYELINATION Lloyd Kasper 11:30 642 - EXTRACELLULAR VESICLE-MEDIATED TRANSFER OF GENETIC INFORMATION BETWEEN THE HEMATOPOIETIC SYSTEM AND THE BRAIN IN RESPONSE TO INFLAMMATION Kirsten Ridder (1) - Sascha Keller (2) - Maria Dams (1) - Anne-kathleen Rupp (2) - Jessica Schlaudraff (3) Domenico Del Turco (3) - Julia Starmann (4) - Jadranka Macas (1) - Darja Karpova (5) Kavi Devraij (1) - Candan Depboylu (6) - Britta Landfried (1) - Bernd Arnold (7) - Karl H. Plate (1) Günter Höglinger (8) - Holger Sültmann (4) - Peter Altevogt (2) - Stefan Momma (1) Institute Of Neurology (edinger Institute), Frankfurt University Medical School, Frankfurt Am Main, Germany (1) Tumor Immunology Program, German Cancer Research Center (dkfz), Heidelberg, Germany (2) - Institute Of Clinical Neuroanatomy, Frankfurt University Medical School, Frankfurt Am Main, Germany (3) - Unit Cancer Genome Research, German Cancer Research Center (dkfz), Heidelberg, Germany (4) - German Red Cross Blood Service Baden-württemberg-hessen And Institute For Transfusion Medicine And Immunohematology, Frankfurt University Medical School, Frankfurt Am Main, Germany (5) - Department Of Neurology, Philipps University Marburg, Marburg, Germany (6) - Division Molecular Immunology, German Cancer Research Center (dkfz), Heidelberg, Germany (7) German Center For Neurodegenerative Diseases E.v. (dzne), Technical University Munich (tum), Munich, Germany (8)

CROSSTALK OF THE IMMUNE AND NERVOUS SYSTEM I 10:00 - 11:45 ROOM C (GUTENBERGSAAL 2)

Chairs: Christine Stadelmann-Nessler, Rogier Hintzen

10:00 MECHANISMS OF IMMUNE MEDIATED TISSUE INJURY IN THE CENTRAL NERVOUS SYSTEM Hans Lassmann

10:23 BALANCE BETWEEN NEUROINFLAMMATION AND NEUROPROTECTION Ralph Gold

10:45 ADAPTIVE IMMUNITY IN MULTIPLE SCLEROSIS: WHAT WE KNOW AND WHAT WE DON’T KNOW (YET) Reinhard Hohlfeld

11:08 VIRUS-INDUCED DEMYELINATING CNS DISEASE Burkhard Ludewig

11:30 48 - THE NOVEL TH17-ASSOCIATED CYTOKINE IL-26 MEDIATES BBB BREAKDOWN AND NEUROINFLAMMATION Bieke Broux - Lamia Hachehouche - Hania Kébir - Simone Terouz - Lyne Bourbonniere - Alexandre Prat Crchum, Université De Montreal, Montreal, Canada

INDUSTRY SPONSORED: HOW IS IMMUNOPATHOGENESIS OF MS DEFINING NEW TREATMENT STRATEGIES? 12:00 - 13:00 PLENARY ROOM (KONGRESS SAAL)

Chair: Hans Peter Hartung

12:00 WELCOME AND INTRODUCTION Hans Peter Hartung 12:05 IMMUNOPATHOGENESIS OF MS - THE ROLE OF LYMPHOCYTES Sven Meuth

12:24 ALMETUZUMAB MECHANISM OF ACTION - CHANGING THE BALANCE OF THE IMMUNE SYSTEM Johanne Kaplan

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Scientific Program

12:42 HOW IMMUNOMODULATION TRANSLATES INTO DURABLE CLINICAL BENEFIT - OVERVIEW OF ALEMTUZUMAB IN ACTIVE RRMS Krzysztof Selmaj

THE NEWSON-DAVIS LECTURE13:00 - 13:45 PLENARY ROOM (KONGRESS SAAL)

Chair: Roland Liblau

13:00 AUTOIMMUNE ENCEPHALITIS: FROM SYMPTOM TO SYNAPSE JOSEP DALMAU

NEUROKINE SPONSORED: MECHANISMS AND THERAPIES OF CNS DISEASE II 13:45 - 15:15 ROOM A (KONGRESS SAAL)

Chair: Carlo Avolio

13:45 474 - CHARACTERIZING OLIGODENDROCYTE LINEAGE CELL FUNCTION BY FLOW CYTOMETRY IN ANIMAL MODELS OF DEMYELINATION Andrew P. Robinson - Jane M. Rodgers - Gwen E. Goings - Stephen D. Miller Northwestern University, University, Chicago, United States

14:00 200 - ROLE OF ENDOGENOUS NEURAL PRECURSOR CELLS IN DEMYELINATION AND REMYELINATION AFTER CUPRIZONE-INDUCED INJURY. Erica Butti (1) - Giulia Berera (1) - Francesca Ruffini (1) - Linda Chaabane (1) - Giorgia Dina (2) - Angelo Quattrini (2) - Giancarlo Comi (3) - Gianvito Martino (1) Neuroimmunology Unit, Division Of Neuroscience, Inspe, San Raffaele Hospital, Milan, Italy (1) - Neuropathology Unit, Division Of Neuroscience, Inspe, San Raffaele Hospital, Milan, Italy (2) - Department Of Neurology And Neurophysiology, Inspe, San Raffaele Hospital, Milan, Italy (3)

14:15 358 - DMF MODULATES PATHOGENIC B CELL FUNCTION IN CHRONIC CNS AUTOIMMUNE DISEASE Sarah Traffehn - Imke Metz - Wolfgang Brück - Martin Weber Institute Of Neuropathology, University Medical Center Göttingen, Göttingen, Germany

14:30 222 - THE IMMUNE-MODULATORY EFFECTS OF FINGOLIMOD ON PHENOTYPE AND FUNCTION OF B CELLS FROM PATIENTS WITH MULTIPLE SCLEROSIS Shiri Blumenfeld (1) - Elsebeth Staun-ram (1) - Ariel Miller (2) Technion- Israel Institute Of Technology, University, Haifa, Israel (1) - Neuroimmunology Unit & Multiple Sclerosis Center, Carmel Medical Center, Hospital, Haifa, Israel (2)

14:45 229 - NATALIZUMAB ANALOGON THERAPY IN A B CELL-DEPENDENT EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS MODEL OF MULTIPLE SCLEROSIS Darius Häusler - Stefan Nessler - Niels Kruse - Wolfgang Brück - Imke Metz Department Of Neuropathology, University Medical Center Göttingen, Göttingen, Germany

15:00 124 - MATRIX METALLOPROTEINASES CAUSE BLOOD-BRAIN BARRIER DISRUPTION IN CENTRAL NERVOUS SYSTEM TUBERCULOSIS. Sara Brilha (1) - Catherine W. M. Ong (2) - Jon S. Friedland (1) Section Of Infectious Diseases And Immunity, Imperial College London, London, United Kingdom (1) - Department Of Medicine, National University Health System, Singapore, Singapore (2)



NEUROINFLAMMATION II 13:45 - 15:15 ROOM B (GUTENBERGSAAL 1)

Chair: Pavel Stourac

13:45 575 - INHIBITION OF SOLUBLE TNF PROTECTS MICE AGAINST BRAIN INFLAMMATION AND DEMYELINATION IN A CUPRIZONE MODEL FOR MULTIPLE SCLEROSIS Maria Karamita (1) - Chris Barnum (2) - Ray Tesi (3) - David Szymkowski (4) - Malu Tansey (5) Lesley Probert (6) Laboratory Of Molecular Genetics, Hellenic Pasteur Institute, Athens, Greece (1) - School Of Medicine, Emory University, Atlanda Ga, United States (2) - Fprt Bio, Frt Bio, Washington, United States (3) - Xencor, Xencor, Monrovia Ca, United States (4) - School Of Medicine, Emory, Atlanda Ga, United States (5) - Laboratoru Of Molecular Genetics, Hellenic Pasteur Institute, Athens, Greece (6)

14:00 525 - DYSREGULATION OF THE APOE-TGFB PATHWAY LEADS TO LOSS OF THE MICROGLIAL HOMEOSTATIC SIGNATURE IN NEUROLOGIC DISEASES INCLUDING MS, ALS AND AD Suzanne Krasemann Krasemann - Charlotte Madore - Ron Cialic Cialic - Zain Fanek Fanek David Greco Greco - Pauline Wu - Camille Doykan - Howard Weiner - Oleg Butovsky Brigham And Women’s Hospital, Harvard Medical School, Boston, United States

14:15 127 - FACTOR XII DRIVES CNS AUTOIMMUNITY VIA CD87-MEDIATED MODULATION OF DENDRITIC CELLS Kerstin Göbel (1) - Chloi Magdalini Asaridou (1) - Susann Pankratz (1) - Stefan Bittner (1) - Alexander M. Herrmann (1) - Johanna Breuer (1) - Martin Herold (1) - Heinz Wiendl (1) - Triantafyllos Chavakis (2) Christoph Kleinschnitz (3) - Sven G. Meuth (1)

Department Of Neurology, University Of Münster, Münster, Germany (1) - Department Of Clinical Pathobiochemistry, Department Of Medicine And Institute For Clinical Chemistry And Laboratory Medicine, University Clinic Carl Gustav Carus, Technical University Of Dresden, Dresden, Germany (2) - Department Of Neurology, University Hospital Würzburg, Würzburg, Germany (3)

14:30 67 - UVB LIGHT ATTENUATES THE SYSTEMIC IMMUNE RESPONSE IN CNS AUTOIMMUNITY Johanna Breuer (1) - Nicholas Schwab (1) - Tilman Schneider-hohendorf (1) - Martin Marziniak (1) Hema Mohan (1) - Urvashi Bhatia (1) - Catharina Groß (1) - Björn Clausen (2) - Carsten Weishaupt (3) Thomas Luger (3) - Sven Meuth (1) - Karin Loser (3) - Heinz Wiendl (1) Department Of Neurology, University Of Münster, Münster, Germany (1) - Institute For Molecular Medicine, Johannes Gutenberg-university Mainz, Mainz, Germany (2) - Department Of Dermatology, University Of Münster, Münster, Germany (3)

14:45 574 - DIFFERENTIAL CONTRIBUTIONS OF MICROGLIAL AND NEURONAL IKKBETA IN SYNAPTIC PLASTICITY AND ASSOCIATIVE LEARNING IN MICE Vasiliki Kyrargyri (1) - German Vega-flores (2) - Agnès Gruart (2) - José M. Delgado-garcía (2) Lesley Probert (1) Laboratory Of Molecular Genetics, Hellenic Pasteur Institute, Athens, Greece (1) - Division Of Neurosciences, Pablo De Olavide University, Seville, Spain (2)

15:00 154 - MCAM IDENTIFIES INFLAMMATORY ENCEPHALITOGENIC CD8 T LYMPHOCYTES PRESENTING A HIGH CYTOTOXIC CAPACITY Catherine Larochelle (1) - Marc-andre Lecuyer (1) - Jorge Ivan Alvarez (1) - Marc Charabati (1) Hania Kebir (1) - Olivia Saint-laurent (1) - Romain Cayrol (1) - Pierre Duquette (2) - Ken Flanagan (3) Nathalie Arbour (1) - Alexandre Prat (1) Crchum, University Of Montreal, Montreal, Canada (1) - Chum, University Of Montreal, Montreal, Canada (2) Prothena, Prothena, San Francisco, United States (3)

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Scientific Program

CLINICAL AND IMMUNOLOGICAL RESEARCH 13:45 - 15:15 ROOM C (GUTENBERGSAAL 2)

Chair: Pablo Villoslada

13:45 402 - A NOVEL NON-RAPID-EYE MOVEMENT (REM) AND REM PARASOMNIA WITH SLEEP BREATHING DISORDER ASSOCIATED WITH ANTIBODIES TO IGLON5 AND TAU DEPOSITS AT POST- MORTEM STUDY Lidia Sabater (1) - Carles Gaig (2) - Ellen Gelpí (3) - Luis Bataller (4) - Jan Lewerenz (5) Estefania Torres-vega (6) - Angeles Contreras (7) - Bruno Giometto (8) - Yaroslau Compta (9) Alex Iranzo (2) - Joan Santamaria (2) - Josep Dalmau (10) - Francesc Graus (11) Institut D’investigacions Biomèdiques August Pi I Sunyer (idibaps), Hospital Clinic De Barcelona, Barcelona, Spain (1) Department Of Neurology, Multidisciplinary Sleep Disorders Unit, Idibaps, Hospital Clinic De Barcelona, Barcelona, Spain (2) - Neurological Tissue Bank Of The Biobanc-hospital Clinic-idibaps Barcelona, Hospital Clinic, Barcelona, Spain (3) Department Of Neurology. Instituto De Investigacion Sanitaria La Fe Department Of Neurology, Hospital Universitari I Politècnic La Fe, Valencia, Spain (4) - Department Of Neurology, Ulm University, Ulm, Germany (5) - Instituto De Investigacion Sanitaria La Fe, Hospital Universitari I Politècnic La Fe, Valencia, Spain (6) - Department Of Neurology, Hospital Morales Messeguer, Murcia, Spain (7) - Department Of Neurology, Regional Hospital “ca Foncello”, Treviso, Italy (8) - Department Of Neurology, Hospital Clinic De Barcelona, Barcelona, Spain (9) - Department Of Pennsylvania, Philadelphia, Pa, Usa And Institut Catalana De Recerca I Estudis Avançats, Idibaps, Hospital Clinic De Barcelona, Barcelona, Spain (10) - Department Of Neurology, Idibaps, Hospital Clinic De Barcelona, Barcelona, Spain (11)

14:00 266 - T CELL SMAD7 MODULATES THE GUT IMMUNE RESPONSE DURING SPONTANEOUS OPTICOSPINAL ENCEPHALOMYELITIS Steffen Haupeltshofer (1) - Alexandra Wolf (2) - Xiomara Pedreitturia (1) - Ralf Gold (1) - Ingo Kleiter (1) Department Of Neuroimmunology, St. Josef Hospital, Bochum, Germany (1) - Department Of Neuroimmunology, Ruhr-universität, Bochum, Germany (2)

14:15 293 - GALECTIN-1 PLAYS AN ESSENTIAL ROLE IN INTRAVENOUS TOLERANCE INDUCTION IN EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS Elisabeth Rose Mari - Javad Rasouli - Guang-xian Zhang - Bogoljub Ciric - A.m. Rostami Thomas Jefferson University, Department Of Neurology, Philadelphia, United States

14:30 53 - NOVEL MECHANISMS OF GLUCOCORTICOIDS IN THE TREATMENT OF MULTIPLE SCLEROSIS Henrike J. Fischer (1) - Nils Schweingruber (1) - Fred Lühder (2) - Mikael Simons (3) - Peter Huppke (4) - Holger M. Reichardt (1) Institute For Cellular And Molecular Immunology, University Of Göttingen Medical School, Göttingen, Germany (1) Department Of Neuroimmunology, Institute For Multiple Sclerosis Research, University Of Göttingen Medical School, Göttingen, Germany (2) - Department Of Neurology, University Of Göttingen Medical School, Göttingen, Germany (3) - Department Of Pediatrics And Pediatric Neurology, University Of Göttingen Medical School, Göttingen, Germany (4)

14:45 390 - DC SPECIFIC SMAD7 DEFICIENCY PROMOTES DIFFERENTIATION OF TOLEROGENIC DCS ABLE TO ATTENUATE EAE Dominika Lukas (1) - Nir Yogev (1) - Junda M. Kel (2) - Lara Jungmann (3) - Marco Prinz (3) Ingo Kleiter (4) - Björn E. Clausen (1) - Ari Waisman (1) Institute For Molecular Medicine, University Medical Center Of The Johannes Gutenberg University, Mainz, Germany (1) - Department Of Immunology, Erasmus Mc, University Medical Center, Rotterdam, Netherlands (2) - Department Of Neuropathology & Centre For Biological Signaling Studies, University Of Freiburg, Freiburg, Germany (3) Department Of Neurology, St. Josef-hospital, Ruhr-university Bochum, Bochum, Germany (4)

15:00 219 - BRAIN-DERIVED MICROVESICLES CONFER SICKNESS BEHAVIOURS BY SWITCHING ON THE ACUTE PHASE RESPONSE IN THE LIVER Yvonne Couch (1) - Matthew C Evans (1) - Chris Gardiner (2) - Ian Sargent (2) - Patrick Losey (1) Kate L Lambertsen (3) - Daniel C Anthony (1) Department Of Pharmacology - Experimental Neuropathology, University Of Oxford, Oxford, United Kingdom (1) Nuffield Department Of Obstetrics And Gynaecology, University Of Oxford, Oxford, United Kingdom (2) - Institute For Molecular Medicine, University Of Southern Denmark, Odense, Denmark (3)



COFFEE BREAK & POSTER SESSION | IMMUNOLOGICAL MECHANISMS 15:15 - 16:45 POSTERHALL (RHEINFOYER)

473 - EVALUATION OF TREGS IN ACHR- AND MUSK-MYASTHENIA GRAVIS: FUNCTIONAL IMPAIRMENT AND MODULATION BY VITAMIN-D3 AND IL21Mahdi Alahgholi HajibehzadDepartment Of Physiology, Istanbul University, Istanbul Medical Faculty, Istanbul, Turkey

241 - INTESTINAL PERMEABILITY IN MULTIPLE SCLEROSISViviana Annibali (1) - Claudia Policano (1) - Maria Chiara Buscarinu (1) - Luana Lionetto (2) - Rosella Mechelli (1) - Matilde Capi (2) - Carlo Mattei (1) - Eleonora Piras (3) - Daniela F. Angelini (3) - Ivan Monteleone (4) - Giovanni Monteleone (4) Luca Battistini (3) - Maurizio Simmaco (5) - Giovanni Ristori (1) - Marco Salvetti (1)

Centre For Experimental Neurological Therapies (centers) - Dep. Of Neurosciences, Mental Health And Sensory Organs., Sapienza, University Of Rome, S. Andrea Hospital Site., Rome, Italy (1) - Diagnostic Molecular Advanced Unit., S. Andrea Hospital., Rome, Italy (2) Neuroimmunology Unit., Santa Lucia Foundation., Rome, Italy (3) - Department Of Systems Medicine., University Of Tor Vergata., Rome, Italy (4) - Diagnostic Molecular Advanced Unit - Dep. Of Neurosciences, Mental Health And Sensory Organs., Sapienza, University Of Rome, S. Andrea Hospital Site., Rome, Italy (5)

366 - UNRAVELING THE REGULATORY ROLE OF NK CELLS ON T-CELL EFFECTOR FUNCTIONS: IMPLICATIONS FOR CNS AUTOIMMUNITY.Eric Armentani (1) - Alice Laroni (1) - Federico Ivaldi (2) - Roopali Gandhi (3) - Ilaria Gandoglia (1) - Emanuela Marcenaro (4) Simona Sivori (4) - Alessandro Moretta (4) - Nicole Kerlero De Rosbo (1) - Howard L. Weiner (3) - Antonio Uccelli (1)

Dinogmi, University Of Genoa, Genoa, Italy (1) - Abc-advanced Biotchenology Center, Aou Sanmartino, Genoa, Italy (2) Harvard Medical School, Harvard, Boston, United States (3) - Dimes, University Of Genoa, Genoa, Italy (4)

121 - IMMUNE CELL ENTRY AND FUNCTION IN RETINAL REPAIRInbal Benhar - Kitty Reemst - Michal SchwartzDepartment Of Neurobiology, Weizmann Institute Of Science, Rehovot, Israel

204 - MECHANISMS UNDERLYING INDUCTION OF ANTIBODY-MEDIATED DEMYELINATION IN MULIPLE SCLEROSISCarsten Tue Berg - Reza M. H Khorooshi - Nasrin Asgari - Trevor Owens Department Of Neurobiology, University Of Southern Denmark, Odense, Denmark )

191 - TOLERANCE INDUCTION BY A FORCED EXPRESSION OF MOG-PEPTIDE IN THE CONTEXT OF EAEStefan Berl - Nir Yogev - Ari WaismanInstitute For Molecular Medicine, Johannes Guthenberg-university Mainz, Mainz, Germany

223 - MONOCYTE DERIVED MICROVESICLES IN PATIENTS WITH MULTIPLE SCLEROSIS. EFFECTS OF CURRENT IMMUNE TREATMENTS FOR THE DISEASEMaria Blonda (1) - Roberta Grasso (1) - Valeria Di Francescantonio (1) - Maria Teresa Sollazzo (1) - Luigi Maria Specchio (1) Roberto Furlan (2) - Carlo Avolio (1)

Dept. Of Medical And Surgical Sciences, University Of Foggia, Foggia, Italy (1) - Neuroimmunology Unit, Institute Of Experimental Neurology, Division Of Neuroscience, San Raffaele Scientific Institute, Milano, Italy (2)

243 - RECURRENT OPTIC NEURITIS IS CHARACTERISED BY ANTI-MOG ANTIBODIES: A FOLLOW-UP STUDYKonstantina Chalmoukou (1) - Haris Alexopoulos (1) - Sofia Akrivou (1) - Panos Stathopoulos (1) - Markus Reindl (2) Marinos Dalakas (1)

Neuroimmunology Unit, Department Of Pathophysiology, Faculty Of Medicine, National And Kapodistrian University Of Athens, Athens, Greece (1) - Clinical Department Of Neurology, Innsbruck Medical University, Innsbruck, Austria (2)

389 - PERIPHERAL TRANSCRIPTIONAL CONTROL IN MULTIPLE SCLEROSIS: HEPATOCYTE NUCLEAR FACTOR 4 ALPHA REGULATES IMMUNE CELL ACTIVATION AND AUTOIMMUNITYMarco Di Dario (1) - Ramesh Menon (1) - Emanuela Colombo (1) - Marta Radaelli (2) - Vittorio Martinelli (2) Giancarlo Comi (2) - Cinthia Farina (1)

Institute Of Experimental Neurology (inspe), San Raffaele Scientific Institute, Milan, Italy (1) - Department Of Neurology, San Raffaele Scientific Institute, Milan, Italy (2)

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Scientific Program

615 - THE PATHWAY TOLL LIKE RECEPTOR 2 - CD44: A PATHOGENETIC MECHANISM AND THERAPEUTIC TARGET FOR INFLAMMATION IN AUTOIMMUNE DISEASEGabriele Di Sante (1) - Mariagrazia Valentini (1) - Alessia Piermattei (1) - Giuseppe Migliara (2) - Barbara Tolusso (3) Gabriela Constantin (4) - Ezio Giorda (5) - Giovanni Delogu (6) - Francesco Ria (1)

Istituto Di Patologia Generale, Università Cattolica Del Sacro Cuore, Roma, Italy (1) - Isituto Di Patologia Generale, Università Cattolica Del Sacro Cuore, Roma, Italy (2) - Istituto Di Reumatologia E Scienze Affini, Università Cattolica Del Sacro Cuore, Roma, Italy (3) - Istituto Di Patologia Generale, Università Di Verona, Verona, Italy (4) - Istituto Di Patologia Generale, Bambino Gesù, Roma, Italy (5)

Istituto Di Microbiologia, Università Cattolica Del Sacro Cuore, Roma, Italy (6)

340 - ACTIVATION OF ENCEPHALITOGENIC T CELLS IN A MOG-INDUCED MARMOSET EAE MODEL IS REGULATED BY LINKED SUPPRESSIONKarin Dijkman (1) - Anwar Jagessar (1) - Erwin Blezer (2) - Robert Weissert (3) - Bert ‘t Hart (1)

Department Of Immunobiology, Biomedical Primate Research Centre, Rijswijk, Netherlands (1) - Image Sciences Institute, University Medical Centre Utrecht, Utrecht, Netherlands (2) - Department Of Neurology, University Of Regensburg, Regensburg, Germany (3)

143 - BENEFICIAL EFFECTS OF SHORT CHAIN FATTY ACIDS ON THE COURSE OF EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITISAlexander Duscha (1) - Johannes Berg (1) - Lisa Hinz (1) - Jan Thöne (1) - Seray Demir (1) - Ralf Gold (1) - Aiden Haghikia (1)

Department Of Neurology, Ruhr-universität, Bochum, Germany (1)

134 - ANTIBODIES TO DNA REPAIR PROTEINS IN HANDL PATIENTSEce Erdag (1) - Erdem Tuzun (1) - Murat Kurtuncu (2) - Burcak Vural (1)

Institute For Experimental Medicine, Istanbul University, Istanbul, Turkey (1) - Faculty Of Medicine, Istanbul University, Istanbul, Turkey (2)

192 - AFFINITY-DEPENDENT EFFECTS OF TERIFLUNOMIDE AND IMPACT ON T CELL METABOLISMMelanie Eschborn (1) - Maren Lindner (1) - Vilmos Posevitz (1) - Dietmar Zehn (2) - Heinz Wiendl (1) - Luisa Klotz (1)

Department Of Neurology, University Hospital Münster, Münster, Germany (1) - Swiss Vaccine Research Institute, University Hospital Lausanne, Lausanne, Switzerland (2)

237 - A GLOBAL IMMUNE DEFICIT IN ALZHEIMER AND MILD COGNITIVE IMPAIRMENT DISCLOSED BY A NOVEL DATA MINING PROCESS Maira GironiInspe, Ospedale San Raffaele, Milano, Italy

553 - DOES DEPENDENT INHIBITION OF IMMUNE MEDIATED DEMYELINATION BY IVIGMeike Winter - Christine Baksmeier - Hans-peter Hartung - Norbert Goebels Department Of Neurology, Heinrich-heine-university, Duesseldorf, Germany

174 - ENDOPLASMIC RETICULUM-STRESS INDUCED BY INFLAMMATION IN SKELETAL MUSCLE CELLS IS ASSOCIATED WITH PROTEIN ACCUMULATION AND REDUCED BY METHYLENE BLUE: IMPLICATIONS FOR INCLUSION BODY MYOSITISChristina Haas (1) - Jana Zschuentzsch (2) - Sven Thoms (3) - Jens Schmidt (2)

Department Of Neuroimmunology, Institute For Multiple Sclerosis Research And Hertie Foundation, University Medical Center Göttingen, Göttingen, Germany (1) - Clinic For Neurology, University Medical Center Göttingen, Göttingen, Germany (2) Clinic For Pediatrics, University Medical Center Göttingen, Göttingen, Germany (3)

530 - LATENT GAMMAHERPEVIRUS INFECTION FACILITATES MULTIPLE SCLEROSIS THROUGH IMMUNE REGULATIONMarc Horwitz (1) - Citlali Marquez Hernandez (2) - Costanza Casiraghi (2) - Iryna Shanina (2)

Microbiology And Immunology - Life Sciences Institute, University Of British Columbia, Vancouver, Canada (1) - Microbiology And Immunology - Life Sciences Institute, Ubc, Vancouver, Canada (2)

565 - PROINFLAMMATORY CYTOKINES, MICRORNAS AND SCHIZOPHRENIASehba Husain-krautter (1) - Juan Gallego (2) - Anil Malhotra (2) - Thomas Rothstein (1)

Feinstein Institute For Medical Research, North Shore-long Island Jewish Health System, Manhasset, United States (1) Zucker Hillside Hospital, North Shore-long Island Jewish Health System, Glen Oaks, United States (2)



396 - ANTI-MURINE CD52 ANTIBODY TREATMENT DOES NOT ADVERSELY AFFECT THE MIGRATORY ABILITY OF IMMUNE CELLSEvis Havari (1) - Michael J Turner (1) - James C Dodge (2) - Christopher Treleaven (2) - Lamya S Shihabuddin (2) Bruce L Roberts (1) - Johanne M Kaplan (1) - William M Siders (1)

Neuroimmunology Research, Genzyme, A Sanofi Company, Framingham, Ma, United States (1) - Neuroscience, Genzyme, A Sanofi Company, Framingham, Ma, United States (2)

177 - INCREASED NEUTRALIZATION CAPACITY OF TNF ALPHA IN SERA OF MS PATIENTS MAY PLAY A ROLE IN - MS PATHOGENESIS AND IS REVERSED BY THERAPY WITH INTERFERON-BKarin Fainberg (1) - Keren Regev (2) - Olga Dorman (1) - Arnon Karni (3)

Neuroimmunology Laboratory, Tel Aviv Medical Center, Tel Aviv, Israel (1) - Neuroimmunology Laboratory, Tel Aviv Medical Center, Tel Aviv, Republic Of Belarus (2) - Neuroimmunology Laboratory, Tel Aviv Medical Center, Sackler’smedical School, Tel Aviv University, Tel Aviv, Israel (3)

385 - LYMPHOCYTE SUBSET DYNAMICS FOLLOWING ALEMTUZUMAB TREATMENT IN PATIENTS WHO RELAPSED ON A PRIOR THERAPYLloyd H Kasper (1) - Douglas L Arnold (2) - Alasdair J Coles (3) - Hans-peter Hartung (4) - Eva Havrdova (5) Krzysztof W Selmaj (6) - Jeffrey Palmer (7) - David H Margolin (7) - Michael A Panzara (7) - D Alastair S Compston (8)

Geisel School Of Medicine At Dartmouth, Geisel School Of Medicine, Hanover, United States (1) - Department Of Neurology And Neurosurgery, Montréal Neurological Institute, Mcgill University, Montréal, Québec, Canada (2) - University Of Cambridge, Addenbrooke’s Hospital, Cambridge, United Kingdom (3) - Department Of Neurology And Center For Neuropsychiatry, Heinrich-heine University, Düsseldorf, Germany (4) - Charles University In Prague, First Medical Faculty, Prague, Czech Republic (5) - Department Of Neurology, Medical University Of Lódz, Lódz, Poland (6) - Genzyme, A Sanofi Company, -, Cambridge, Ma, United States (7) Department Of Clinical Neurosciences, University Of Cambridge, Cambridge, United Kingdom (8)

482 - VAV1 CONTROLS T CELL POLARIZATION AND SUSCEPTIBILITY TO CENTRAL NERVOUS SYSTEM AUTOIMMUNITYSahar Kassem (1) - Guillaume Gaud (1) - Anne Dejean (1) - Isabelle Bernard (1) - Gilbert J Fournie (1) - Bernard Malissen (2) Céline Colacios (1) - Abdelhadi Saoudi (1)

Inserm U1043, Université Paul Sabatier, Toulouse, France (1) - Ciml, Université Aix Marseille, Marseille, France (2)

331 - ROLE OF MENINGEAL LYMPHOID FOLLICLE-LIKE STRUCTURES IN THE CNS INFLAMMATORY DISORDERSIzumi Kawachi (1) - Mariko Hokari (1) - Etsuji Saji (1) - Yasuko Toyoshima (2) - Akiko Yokoseki (1) - Akiyoshi Kakita (2) - Hitoshi Takahashi (2) Masatoyo Nishizawa (1)

Department Of Neurology, Brain Research Institute, Niigata University, Niigata, Japan (1) - Department Of Pathology, Brain Research Institute, Niigata University, Niigata, Japan (2)

539 - THE ROLE OF HYALURONAN AND 4-METHYLUMBELLIFERONE TREATMENTIN MULTIPLE SCLEROSISHedwich F Kuipers - Mary Rieck - Lawrence Steinman - Paul L Bollyky Stanford University, Stanford University Medical Center, Stanford, Ca, United States

509 - TRYPTOPHAN-2,3-DIOXYGENASE IN EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS.Tobias V. Lanz (1) - Simon Becker (1) - Simeon Iwantscheff (1) - Carl Grabitz (1) - Laura-ines Böhler (1) Wolfgang Wick (2) - Michael Platten (2)

Ccu Neuroimmunology And Brain Tumor Immunology, German Cancer Research Center (dkfz), Heidelberg, Germany (1) Department Of Neurooncology, University Hospital Heidelberg, Heidelberg, Germany (2)

360 - SOLUBLE BCMA IS SHED FROM B CELLS BY GAMMA-SECRETASE, FUNCTIONS AS APRIL-SPECIFIC DECOY AND REFLECTS INTRATHECAL IG-PRODUCTION IN MULTIPLE SCLEROSISSarah A. Laurent (1) - Franziska Hoffmann (1) - Peer-hendrik Kuhn (2) - Stephanie M. Hauck (3) - Mohsen Khademi (4) Tomas Olsson (4) - Hans-walter Pfister (5) - Frank Weber (6) - Reinhard Hohlfeld (1) - Stefan F. Lichtenthaler (2) Edgar Meinl (1)

Institute Of Clinical Neuroimmunology, Ludwig Maximilian University, Munich, Germany (1) - Neuroproteomics, Technical University, Munich, Germany (2) - Research Unit Protein Science, Helmholtz Zentrum, Munich, Germany (3) - Division Of Clinical Neuroscience, Karolinska University Hospital, Stockholm, Sweden (4) - Department Of Neurology, Klinikum Grosshadern, Ludwig Maximilian University, Munich, Germany (5) - Neurology, Max-planck-institute Of Psychiatry, Munich, Germany (6)

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Scientific Program

516 - CRITICAL CONTRIBUTION FROM ANTIGEN PRESENTING CELLS FOR ENCEPHALITOGENIC T CELLSPriscilla Lee - Alan Smith - Yuhong Yang - Amanda Selhorst - Michael Racke - Amy Lovett-racke Wexner Medical Center, The Ohio State University, Columbus, United States

81 - ELEVATED NKG2D LIGANDS EXPRESSION IN EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITISLaurine Legroux (1) - Camille Pittet (1) - Gabrielle Deblois (1) - Chanel Cadieux-dion (1) - Alma N Mohebiany (2) Diane Beauseigle (1) - Nathalie Arbour (1)

Université De Montréal, Crchum, Montreal, Canada (1) - Universität Mainz, Johannes Gutenberg, Mainz, Germany (2)

201 - MOLECULAR ANALYSIS OF THE CLEC16A AUTOIMMUNE RISK LOCUS Ingvild Sørum Leikfoss (1) - Pankaj Keshari (1) - Steffan D. Bos (2) - Anna M. Eriksson (3) - Anja Bjølgerud (2) Vibeke Sundvold-gjerstad (4) - Greger Abrahamsen (4) - Anne Spurkland (4) - Hanne F. Harbo (1) - Tone Berge (1)

Department Of Neurology, Oslo University Hospital, Oslo, Norway (1) - Institute Of Clinical Medicine, University Of Oslo, Oslo, Norway (2) Institute Of Biosciences, University Of Oslo, Oslo, Norway (3) - Institute Of Basic Medical Science, University Of Oslo, Oslo, Norway (4)

381 - “SUPERIOR” DOMINANT PEPTIDE ITSELF SHUT DOWN THE REACTIVATION OF AN ANIMAL MODEL OF MULTIPLE SCLEROSIS THROUGH LATER ACTIVATION OF ANTIGEN-SPECIFIC REGULATORY CELLS: APPLICATION FOR INVERSE VACCINE.Youwei LinNational Institute Of Neuroscience, National Center Of Neurology And Psychiatry, Tokyo, Japan

104 - INTEGRATIVE ANALYSIS OF DNA METHYLATION AND GENE EXPRESSION IDENTIFIES DISTINCT PROFILES AMONG IMMUNE CELLS SUBSETSShimrat Mamrut (1) - Nili Avidan (1) - Elsebeth Staun-ram (1) - Elizabeta Ginzburg (1) - Frédérique Truffault (2) Mélinée Frenkian (2) - Sonia Berrih-aknin (2) - Ariel Miller (3)

Rappaport Faculty Of Medicine, Technion-israel Institute Of Technology, University, Haifa, Israel (1) - Research Unit (inserm U974/cnrs Umr7215/ /upmc Um76/aim) – Institute Of Myology Pitié-salpêtrière, University, Paris, France (2) - Division Of Neuroimmunology And Multiple Sclerosis Center, Carmel Medical Center, Hospital, Haifa, Israel (3)

393 - ORAL TOLERANCE INDUCTION IN EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS WITH CANDIDA EXPRESSING A SPECIFIC MOG PEPTIDEAnne K. Mausberg (1) - Christoph Bürth (2) - Maximilian K. Heininger (1) - Mark Stettner (1) Joachim Ernst (2) - Bernd C. Kieseier (1)

Department Of Neurology, Heinrich-heine-university, Duesseldorf, Germany (1) Department Of Molecular Mycology, Heinrich-heine-university, Duesseldorf, Germany (2)

255 - C-TYPE LECTINS ON MYELOID CELLS GOVERN SUSCEPTIBILITY TO EAE IN RATSMarie Ndiaye - Sevasti Flytzani - Andreas Warnecke - Andre Ortlieb - Tomas Olsson - Maja Jagodic Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden

480 - A TH17/LYMPHOTOXIN AXIS ENABLES CYTOKINE PRODUCTION BY BRAIN MENINGEAL STROMAL CELLS AND PROPAGATES DE NOVO CNS-INTRINSIC T CELL RESPONSES DURING INFLAMMATIONNatalia Pikor (1) - Jillian Astarita (2) - Robert Kay (1) - Shannon Turley (2) - Jennifer Gommerman (1)

Department Of Immunology, University Of Toronto, Toronto, Canada (1) - Department Of Cancer Immunology And Aids, Dana Farber Cancer Institute, Boston, United States (2)

41 - BAFF EXPRESSION IN THE HUMAN MONOCYTE CELL LINE THP-1: DIFFERENTIAL REGULATION BY INTERFERONS, IL-10, AND TNFSamia Ragheb (1) - Robert Lisak (2)

Oakland University, Oakland University William Beaumont School Of Medicine (ouwb), Rochester, Michigan, United States (1) Wayne State University, Detroit Medical Center, Detroit, United States (2)

536 - LLAMA-DERIVED NANOBODIES CAN ACT AS P2X7 ANTAGONISTS IN VITRO AND IN VIVOBjörn Rissiek (1) - Welbeck Danquah (2) - Domenica Iacenda (1) - Maike Cordes (1) - Friedrich Koch-nolte (2) - Tim Magnus (1)

Department Of Neurology, University Medical Center Hamburg-eppendorf, Hamburg, Germany (1) - Department Of Immunology, University Medical Center Hamburg-eppendorf, Hamburg, Germany (2)



489 - LFA-1 INTEGRIN CONTROLS TH1 AND TH17 INTRAPARENCHYMAL MOTILITY BEHAVIOR IN THE CENTRAL NERVOUS SYSTEM DURING EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITISBarbara Rossi - Silvia Dusi - Antonella Amoruso - Genny Piacentino - Gabriela Constantin Department Of Pathology And Diagnostics, University Of Verona, Verona, Italy

83 - HMGB1 AND RAGE IN SKELETAL MUSCLE INFLAMMATION: IMPLICATIONS FOR PROTEIN ACCUMULATION IN INCLUSION BODY MYOSITIS (IBM)Ingrid E. Muth (1) - Konstanze Kleinschnitz (2) - Peter Balcarek (3) - Arne Wrede (4) - Olivia Schreiber (5) - Stephan Zierz (6) Marinos C. Dalakas (7) - Reinhard E. Voll (8) - Jens Schmidt (1)

Clinic For Neurology, University Medical Centre Göttingen, Göttingen, Germany (1) - Depertment Of Neuroimmunology, University Medical Centre Göttingen, Göttingen, Germany (2) - Department Of Trauma Surgery, University Medical Centre Göttingen, Göttingen, Germany (3) - Department Of Neuropathology, University Medical Centre Göttingen, Göttingen, Germany (4) - Friedrich-baur-institute, University Of München, München, Germany (5) - Department Of Neurology, University Of Halle, Halle, Germany (6) Neuroimmunology Unit, Dept. Of Pathophysiology, University Of Athens Medical School, Athens, Greece (7) Department Of Rheumatology And Clinical Immunology, University Medical Centre Freiburg, Freiburg, Germany (8)

383 - THE ROLE OF TNF IN CONTROLLING THE SPONTANEOUS DEVELOPMENT OF AUTOIMMUNE NEUROINFLAMMATIONNora Schweizer (1) - Cinzia Tiberi (2) - Elisabeth Rushing (2) - Hans Welzl (3) - Mirjana Wojtal (1) - Tobias Suter (1)

Neuroimmunology And Ms Research, University Hospital Zurich, Zurich, Switzerland (1) - Neuropathology, University Hospital Zurich, Zurich, Switzerland (2) - Institute For Anatomy, University Hospital Zurich, Zurich, Switzerland (3)

460 - CASPASE-1 SIGNALING LINKS MONOCYTE ACTIVATION AND PYROPTOTIC LYMPHOCYTOPENIA AFTER ACUTE BRAIN INJURY Vikramjeet Singh - Stefan Roth - Gemma Llovera - Arthur Liesz Institut Für Schlaganfall- Und Demenzforschung (isd), Klinikum Der Universität München, München, Germany

414 - SCHWANN CELL LOCOMOTION DURING PERIPHERAL NERVE INFLAMMATIONMark Stettner - Sandra Labus - Jan-philipp Weinberger - Thomas Dehmel - Angelika Derksen - Anne K Mausberg Bernd C KieseierDepartment Of Neurology, Heinrich-heine-university, Dusseldorf, Germany

354 - TH1 POLARIZATION OF T CELLS INJECTED INTO THE CEREBROSPINAL FLUID INDUCES BRAIN IMMUNOSURVEILLANCEItai Strominger - Yair Fisher - Shva Biton - Anna Nemirovsky - Rona Baron - Alon Monsonego The Shraga Segal Dept. Of Microbiology, Immunology, And Genetics, Faculty Of Health Sciences, Ben Gurion University Of The Negev, Beer Sheva, Israel

231 - THE INFLAMMASOME PYRIN CONTRIBUTES TO PERTUSSIS TOXIN-INDUCED IL-1Β SYNTHESIS, NEUTROPHIL INTRAVASCULAR CRAWLING AND AUTOIMMUNE ENCEPHALOMYELITISLuc Vallieres (1) - Aline Dumas (1) - Nathalie Amiable (1) - Juan Pablo De Rivero Vaccari (2) - Jae Jin Chae (3) Robert W. Keane (4) - Steve Lacroix (1)

Laval University, Chu De Quebec, Quebec, Canada (1) - The Miami Project To Cure Paralysis, University Of Miami, Miami, United States (2) Medical Genetics Branch, National Human Genome Research Institute, Bethesda, United States (3) - Department Of Physiology And Biophysics, University Of Miami, Miami, United States (4)

612 - MS-ASSOCIATED GENE CLEC16A USES THE MOLECULAR MACHINERY OF LATE ENDOSOMAL BIOGENESIS TO CONTROL HLA-II EXPRESSION IN APCMarvin M. Van Luijn (1) - Karim L. Kreft (1) - Marlieke L. Jongsma (2) - Steven W. Mes (1) - Annet F. Wierenga-wolf (1) Marjan Van Meurs (1) - Marie-josé Melief (1) - Rik Van Der Kant (2) - Lennert Janssen (2) - Hans Janssen (2) John J. Priatel (3) - Rusung Tan (3) - Jacques Neefjes (2) - Jon D. Laman (1) - Rogier Q. Hintzen (1)

Erasmus Mc, University Medical Center Rotterdam, Ms Centre Erasms, Rotterdam, Netherlands (1) - The Netherlands Cancer Institute, Division Of Cell Biology, Amsterdam, Netherlands (2) - Child And Family Research Institute, University Of British Columbia, Vancouver, Canada (3)

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Scientific Program

261 - SURFEN, A PROTEOGLYCAN ANTAGONIST, REDUCES LYSOLECITHIN-INDUCED DEMYELINATION WITH RELATED EFFECTS ON MACROPHAGE FUNCTIONJordan Warford (1) - Laurence Madara (2) - David Hoskin (3) - Alexander Easton (4)

Department Of Pathology, Dalhousie University, Halifax, Ns, Canada (1) - Department Of Microbiology And Immunology, Dalhousie University, Halifax, Nova Scotia, Canada (2) - Departments Of Pathology, Microbiology And Immunology, And Surgery, Dalhousie University, Halifax, Nova Scotia, Canada (3) - Departments Of Pathology, Microbiology And Immunology, And Neurosurgery, Dalhousie University, Halifax, Nova Scotia, Canada (4)

555 - PYTMS: A USEFUL MODELING TOOL FOR COMMON POST-TRANSLATIONAL MODIFICATIONSAndreas Warnecke (1) - Tatyana Sandalova (2) - Adnane Achour (2) - Robert A. Harris (1)

Centre For Molecular Medicine, Department Of Clinical Neuroscience, Applied Immunology & Immunotherapy, Karolinska University Hospital Solna, Karolinska Institutet, Stockholm, Sweden (1) - Science For Life Laboratory, Department Of Medicine Solna, Karolinska Institutet, Stockholm, Sweden (2)

190 - THE ASSESSMENT OF IMMUNOMODULATORY EFFECTS OF CELL THERAPY IN MULTIPLE SCLEROSIS PATIENTS AFTER AUTOLOGOUS MESENCHYMAL/STROMAL STEM CELLS TRANSPLANTATIONMarina Zafranskaya (1) - Alexander Fedulov (2) - Marija Yurkevich (1) - Svetlana Kulinich (1) - Halina Ivanchik (3) Alexei Borisov (4) - Tatiana Kachan (2) - Darya Nizheharodava (1)

Belarusian Medical Academy Of Post-graduate Education, Belarusian Medical Academy Of Post-graduate Education, Minsk, Republic Of Belarus (1) - Belarusian State Medical University, Belarusian State Medical University, Minsk, Republic Of Belarus (2) - Belarusian Medical Academy Of Post-graduate Education, Belarusian Medical Academy Of Post-graduate Education, Minsk, Republic Of Belarus (3) Belarusian State Medical University, Belarusian State Medical University, Minsk, Republic Of Belarus (4)

15 - NEURITOGENIC TH17 CELLS IN GUILLAIN-BARRÉ SYNDROME AND EXPERIMENTAL AUTOIMMUNE NEURITISHongliang Zhang - Xu Wang - Jie Zhu Neuroscience Center, Department Of Neurology, The First Hospital, Jilin University, Changchang, China

COFFEE BREAK & POSTER SESSION | GENETICS 15:15 - 16:45 POSTERHALL (RHEINFOYER)

513 - GENE EXPRESSION IN SMOKING AND NON-SMOKING PATIENTS WITH MULTIPLE SCLEROSISCecilie Ammitzboell - Rikke Ratzer - Lars Börnsen - Freja Bekner - Per Soelberg Sorensen - Jeppe Romme Christensen Helle Bach Soendergaard - Finn Sellebjerg

Danish Multiple Sclerosis Center, University Of Copenhagen, Rigshospitalet, Copenhagen, Denmark

194 - METHYLATION PROFILES OF UNTREATED MS PATIENTS AND CONTROLS FOR WHOLE BLOOD, CD4+ AND CD8+ T CELLS SHOW NO CONSISTENT CHANGE OF METHYLATION LEVELS IN MS.Steffan D Bos (1) - Christian M Page (1) - Bettina K Andreassen (2) - Emon Elboudwarej (3) - Marte W Gustavsen (4) Farren Briggs (3) - Hong Quach (3) - Ingvild Leikfoss (1) - Anja Bjølgerud (1) - Tone Berge (4) - Hanne F Harbo (4) Lisa Barcellos (3)

Institute Of Clinical Medicine, University Of Oslo, Oslo, Norway (1) - Institute Of Basic Medical Sciences, University Of Oslo, Oslo, Norway (2) - Division Of Epidemiology, University Of California, Berkeley, Berkeley, United States (3) - Department Of Neurology, Oslo University Hospital, Oslo, Norway (4)

387 - SNPS IN THE SOCS1 AREA ARE STRONGLY ASSOCIATED WITH MULTIPLE SCLEROSIS AND MAY AFFECT REGULATORY T CELLS AND DENDRITIC CELLSAitzkoa Lopez De Lapuente (1) - Maria Jesus Pinto (2) - Manuel Comabella (3) - Alfredo Antigüedad (4) - Ianire Astobiza (5) Iraide Alloza (5) - Oscar Fernandez (2) - Koen Vandenbroeck (6)

Universidad Del País Vasco, Universidad Del País Vasco, Zamudio, Spain (1) - Clinical Neurosciences Institute, Hospital Regional Universitario Carlos Haya, Málaga, Spain (2) - Centre D’esclerosi Múltiple De Catalunya, Cem-cat Unitat De Neuroimmunologia Clínica, Hospital Universitari Vall D’hebron, Barcelona, Spain (3) - Servicio De Neurología, Hospital De Basurto, Hospital De Basurto, Bilbao, Spain (4) - Universidad Del País Vasco, Universidad Del País Vasco, Leioa, Spain (5) - Ikerbasque Basque Foundation For Science, Universidad Del País Vasco, Bilbao, Spain (6)



455 - EPSTEIN BARR VIRUS NUCLEAR ANTIGEN 2 BINDING SITES DISTRIBUTION OVERLAP WITH MS-ASSOCIATED REGIONSVito Ag Ricigliano (1) - Adam Handel (2) - Viviana Annibali (3) - Claudia Policano (3) - Giovanni Ristori (3) Marco Salvetti (3) - Rosella Mechelli (3)

Neuroimmunology Unit, Fondazione Santa Lucia (i.r.c.c.s.), Rome, Italy (1) - The Weatherall Institute Of Molecular Medicine, University Of Oxford, John Radcliffe Hospital, Oxford Ox3 9ds, United Kingdom (2) - Centre For Experimental Neurological Therapies (centers), Department Of Neurosciences, Mental Health And Sensory Organs, Sapienza University Of Rome, Rome, Italy (3)

450 - CHARACTERIZATION OF ZFP36L1 IN THE CONTEXT OF MULTIPLE SCLEROSIS AND FUNCTIONAL IMMUNOLOGICAL CONSEQUENCES ASSOCIATED WITH THE SUSCEPTIBILITY TO THE DISEASELinda Ottoboni (1) - Khadir Radassi (2) - Philip De Jager (3) - Giancarlo Comi (1) - Cinthia Farina (1) - Gianvito Martino (1)

Institute Of Experimental Neurology, San Raffaele Hospital, Milan, Italy (1) - Neurology, Yale School Of Medicine, Milan, Italy (2) Center For Neurologic Diseases, Brigham And Women’s Hospital, Boston, United States (3)

75 - FROM TRANSCRIPTOME TO IMPRINTING: HOW DOES PARENT-OF-ORIGIN EFFECT CD4+ T CELL ACTIVATION?Sabrina Ruhrmann (1) - Marie N´diaye (1) - Petra Bergman (1) - Victor Guryev (2) - Maja Jagodic (1)

Department Of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden (1) - European Research Institute For The Biology Of Ageing, University Medical Center Groningen/university Of Groningen, Groningen, Netherlands (2)

521 - THE CD33 ALZHEIMER’S DISEASE LOCUS: CORRECTING THE FUNCTIONAL CONSEQUENCES OF THE RISK ALLELE USING SMALL MOLECULESKatie J Ryan (1) - Justin D Boyd (2) - Vanessa Laversenne (2) - Gail Chan (1) - Phoebe Winn (1) - Michael Frangieh (1) Maria Cimpean (1) - Alison Mchenry (1) - Lori B Chibnik (1) - Marcie A Glicksman (2) - Philip L Dejager (1) Elizabeth M Bradshaw (1)

Center For Neurological Diseases, Brigham And Women’s Hospital / Harvard Medical School, Boston, United States (1) - Laboratory For Drug Discovery In Neurodegeneration, Harvard Neurodiscovery Center / Brigham And Women’s Hospital, Boston, United States (2)

592 - COPY NUMBER VARIATIONS IN T CELL RECEPTOR LOCI ARE ASSOCIATED WITH SUSCEPTIBILITY TO MULTIPLE SCLEROSIS AND NEUROMYELITIS OPTICAShinya Sato (1) - Ken Yamamoto (2) - Takuya Matsushita (1) - Noriko Isobe (1) - Yuji Kawano (1) - Kyoko Iinuma (1) Tomomi Yonekawa (1) - Katsuhisa Masaki (1) - Satoshi Yoshimura (1) - Ryo Yamasaki (3) - Jun-ichi Kira (1)

Department Of Neurology, Neurological Institute, Graduate School Of Medical Sciences, Kyushu University, Fukuoka, Japan (1) Division Of Genomics, Research Center For Transomics Medicine, Medical Institute Of Bioregulation, Kyushu University, Fukuoka, Japan (2) - Department Of Neurological Therapeutics, Neurological Institute, Graduate School Of Medical Sciences, Kyushu University, Fukuoka, Japan (3)

348 - CHARACTERIZATION OF GENETIC VARIANTS IN THE NFKBIA PROMOTER REGION IN MULTIPLE SCLEROSISJun Yan (1) - Judith Greer (1) - Pamela Mccombe (1) - Michael Pender (2) - Anzgene Consortium (3)

Uq,centre For Clinical Research, University Of Queensland, Brisbane, Australia (1) - School Of Medicine, University Of Queensland, Brisbane, Australia (2) - Ms Research Australia, Consortium, Sydney, Australia (3)

COFFEE BREAK & POSTER SESSION | MIRNA 15:15 - 16:45 POSTERHALL (RHEINFOYER)

395 - IDENTIFICATION OF MICRORNA CHANGES IN THE THIRD TRIMESTER OF PREGNANCY COMPARED TO THE POST-PARTUM PERIOD IN MULTIPLE SCLEROSIS PATIENTSHelle Bach Søndergaard (1) - Laura Airas (2) - Joy Mendel-hartvig (1) - Per Soelberg Sørensen (1) - Finn Sellebjerg (1)

Danish Multiple Sclerosis Center, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark (1) Department Of Neurology, Turku University Hospital, Turku, Finland (2)

144 - EFFECT OF MS-RELATED MIRNA ON ASTROCYTIC PROLIFERATIONJohannes Berg - Xenia Bytko - Christina Waldhoff - Lisa Hinz - Ralf Gold - Aiden Haghikia Department Of Neurology, Ruhr-universität Bochum, Bochum, Germany

47

Scientific Program

36 - DECREASED MIR-219 EXPRESSION IN MS: CLINICAL IMPLICATIONS?Ilona Bruinsma (1) - Susan Van Vugt (1) - Hanneke Ter Burg (1) - Timothy Van De Lisdonk (1) - Evert-jan Kooi (2) Sergio Baranzini (3) - Xuhuai Ji (4) - Jeroen Geurts (2) - Rogier Hintzen (5) - Marcel Verbeek (1) - Lawrence Steinman (4) Brigit De Jong (1)

Radboud University Medical Center, Hospital, Nijmegen, Netherlands (1) - Vu Medical Center, Hospital, Amsterdam, Netherlands (2) Ucsf, University, San Francisco, United States (3) - Stanford University, University, Stanford, United States (4) - Erasmusmc, Hospital, Rotterdam, Netherlands (5)

76 - METHYLOME CHARACTERIZATION OF CD4+T CELLS IN MULTIPLE SCLEROSIS - ESTABLISHING A ROLE FOR MIR-21 IN AUTOIMMUNE DISEASESabrina Ruhrmann (1) - Eliane Piket (1) - Petra Bergman (1) - Lara Kular (1) - Julio Cesar Cetrulo Lorenzi (1) - Shahin Aeinehband (1) - Roham Parsa (1) - David Gomez-cabrero (2) - Jesper Tegnér (2) - Fredrik Piehl (1) - Maja Jagodic (1)

Department Of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden (1) - Department Of Medicine, The Unit Of Computational Medicine, Karolinska Institute, Stockholm, Sweden (2)

COFFEE BREAK & POSTER SESSION | NEUROINFLAMMATION 15:15 - 16:45 POSTERHALL (RHEINFOYER)

485 - AN IMPORTANT ROLE FOR PROKINETICIN 2 IN AUTOIMMUNE CNS DEMYELINATIONMhamad Abou-hamdan (1) - Massimo Costanza (1) - Elena Fontana (2) - Silvia Musio (1) - Marco Di Dario (3) Cenzo Congiu (4) - Valentina Onnis (4) - Roberta Lattanzi (5) - Lucia Negri (5) - Pietro Luigi Poliani (2) - Cinthia Farina (3) Gianfranco Balboni (4) - Lawrence Steinman (6) - Rosetta Pedotti (1)

Neuroimmunology And Neuromuscular Disorder Unit, Neurological Institute Foundation Irccs Carlo Besta, Milan, Italy (1) - Department Of Pathology, University Of Brescia, Brescia, Italy (2) - Institute Of Experimental Neurology, San Raffaele Scientific Institute, Milan, Italy (3) - Department Of Life And Environmental Sciences, Pharmaceutical, Pharmacological And Nutraceutical Sciences Unit, University Of Cagliari, Cagliari, Italy (4) - Department Of Physiology And Pharmacology Vittorio Erspamer, Sapienza University Of Rome, Rome, Italy (5) - Department Of Neurology, Stanford University, Stanford, United States (6)

158 - EXPRESSION OF ADAMTS-9 IN THE CENTRAL NERVOUS SYSTEM IN MULTIPLE SCLEROSIS AND ITS RELATIONSHIP TO CLEAVAGE OF AGGRECAN AND VERSICANEsadawi Abuneeza (1) - Alison Cross (2) - Gail Haddock (2) - Rowena Bunning (3) - Nicola Woodroofe (4)

Phd Student, Sheffield Hallam University, Sheffield, United Kingdom (1) - Senior Lecturer In Biomedical Science, Sheffield Hallam University, Sheffield, United Kingdom (2) - Principal Lecturer In Cell Biology, Sheffield Hallam University, Sheffield, United Kingdom (3) Professor Of Neuroimmunology And Head Of The Bmrc, Sheffield Hallam University, Sheffield, United Kingdom (4)

63 - TWO-PORE DOMAIN POTASSIUM CHANNELS ARE NOVEL TARGETS FOR AUTOIMMUNE MYOPATHIES BY INFLUENCING BASIC CELLULAR PARAMETERS IN MURINE MUSCLE CELLS.Ali Maisam Afzali - Stefan Bittner - Tobias Ruck - Alexander Herrmann - Sarah Glumm - Janette Iking Heinz Wiendl - Sven G. Meuth Department Of Neurology, University Hospital Münster, Münster, Germany

263 - A ROLE FOR INFLAMMATION IN THE PROGRESSION OF AGE-RELATED HEARING LOSSAkosua Agyemang-prempeh Agyemang-prempeh (1) - Carl Verschuur Verschuur (1) - Tracey A Newman Newman (2)

Hearing And Balance Centre, Institute Of Sound And Vibration Research, University Of Southampton, Southampton, United Kingdom (1) Institute For Life Sciences, Faculty Of Medicine, University Of Southampton, Southampton, United Kingdom (2)

600 - DIET-INDUCED OBESITY ENHANCES THE SEVERITY OF EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS J. Jennifer Ahn (1) - Xavier Revelo (2) - Daniel A. Winer (2) - Shannon E. Dunn (2)

Department Of Immunology, University Of Toronto, Toronto, Canada (1) - Toronto General Research Institute, University Health Network, Toronto, Canada (2)

239 - BOTH CD4+ AND CD8+ T –CELL CLONES INFILTRATE THE BRAIN IN A CASE OF BILATERAL RASMUSSEN ENCEPHALITIS.Faiez Al Nimer Neuroimmunology And Multiple Sclerosis Research, Department Of Neurology, University Hospital Zurich, Zurich, Switzerland



132 - LOSS OF FUNCTION DUE TO NEUROINFLAMMATION: A ROLE FOR OXYGEN THERAPY?Mario Amatruda (1) - Alina Matis (1) - Maren Lindner (2) - Christopher Linington (2) - Kenneth Smith (1)

Institute Of Neurology, University College London, London, United Kingdom (1) - Institute Of Infection, Immunity And Inflammation, University Of Glasgow, Glasgow, United Kingdom (2)

382 - ASSESSING OF ANTI-INFLAMMATORY EFFECT OF SMALL NETTLE’ (URTICA URENS) INCREASING POLARITY EXTRACTSSevki Arslan (1) - Gulsum Terzioglu (1) - Serkan Elcil (2) - Hasalettin Deligoz (2) - Alaattin Sen (1)

Department Of Biology, Pamukkale University, Denizli, Turkey (1) - Department Of Chemistry, Pamukkale University, Denizli, Turkey (2)

345 - THE ROLE OF CCR6 IN ISCHEMIC STROKEPriyadharshini Arunachalam - Mathias Gelderblom - Tim Magnus Department Of Neurology (experimental Research In Stroke And Inflammation -ersi ), Universitätsklinikum Hamburg-eppendorf, Hamburg, Germany

334 - EFFECTS OF NUTRITION ON LEUCOCYTE INFILTRATION AND NEUROGENESIS AFTER STROKE IN AGED RATSRomy Baguhl (1) - Christy Joseph (2) - Theofilos Tsakmakides (1) - Alexander Dressel (1)

Department Of Neuroimmunology, Clinic Of Neurology, University Medicine Greifswald, Greifswald, Germany (1) - Department Of Pathology, University Medicine Greifswald, Greifswald, Germany (2)

558 - DEFINING THE ROLE OF IL-23 IN AUTOIMMUNE NEUROINFLAMMATIONMelania Balzarolo (1) - Andrew L. Croxford (1) - Tom Hartwig (1) - Pavel Pelczar (2) - Burkhard Becher (1)

Institute Of Experimental Immunology, University Of Zurich, Zurich, Switzerland (1) - Institute Of Laboratory Animal Science, University Of Zurich, Zurich, Switzerland (2)

88 - A NOVEL CONNECTION OF AUTOPHAGY RELATED GENE 7 TO MULTIPLE SCLEROSIS AND EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITISRasmus Berglund (1) - Melanie Thessen Hedreul (1) - Roham Parsa (2) - Petra Bergman (1) - Maja Jagodic (1) Tomas Olsson (1) - Andre Ortlieb Guerreiro Cacais (1) - Jenny Link (3) - Mohsen Khademi (1) - Ingrid Kockum (3) Juliane Becher (4) - Francesco Cecconi (4)

Dept. Of Clinical Neuroscience. Neuroimmunology Unit, Karolinska Institute, Stockholm, Sweden (1) - Dept. Of Clinical Neuroscience, Applied Immunology, Karolinska Institute, Stockholm, Sweden (2) - Dept. Of Clinical Neuroscience. Multiple Sclerosis Research Gruop, Karolinska Institute, Stockholm, Sweden (3) - Labarotory Of Molecular Neuroembryology, Irccs Fondazione, Santa Lucia, Rome, Italy (4)

327 - CNS TISSUE RESPONSE TO INFLAMMATIONSabina Berl - Ari Waisman Molecular Medicine, Johannes-gutenberg-university, Mainz, Germany

635 - EFFECT OF NATALIZUMAB TREATMENT ON CIRCULATING CD4+CD62L+ T-CELLS IN MULTIPLE SCLEROSIS PATIENTS.Antonio Bertolotto (1) - Fabiana Marnetto (1) - Marzia Caldano (1) - Alessandra Lugaresi (2) - Michela Spadaro (1)

Aou San Luigi Gozaga, Clinical Neurobiology Unit, Regional Referring Multiple Sclerosis Center (cresm), Orbassano, Turin, Italy (1) Dept Neuroscience, Imaging And Clinical Sciences, University ‘g. D’annunzio’, Chieti, Italy (2)

307 - NEUROPATHOLOGICAL EVALUATION OF FOUR DANISH CASES OF CLIPPERS: EVIDENCE OF GENERALIZED NEUROINFLAMMATION BUT NO PRE-LYMPHOMAMorten Blaabjerg (1) - Bjarne Winther Kristensen (2) - Daniel Kondziella (3) - Bjørg Morell Kerrn-jespersen (3) Mette Lindelof (4) - Zsolt Illes (1)

Department Of Neurology, Odense University Hospital, Odense, Denmark (1) - Department Of Pathology, Odense University Hospital, Odense, Denmark (2) - Department Of Neurology, Copenhagen University Hospital, Copenhagen, Denmark (3) - Department Of Neurology, Herlev Hospital, Herlev, Denmark (4)

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Scientific Program

437 - SEX DEPENDENT INFLUENCES OF APOLIPOPROTEIN E ON THE EXPRESSION OF ATP-BINDING CASSETTE TRANSPORTERS DURING EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITISAnne Böhme - Lisa Schrewe - Ralf Gold - Andrew Chan Department Of Neurology, Ruhr-universität Bochum, Bochum

568 - MATERNAL OBESITY DECREASES GFAP EXPRESSION IN HYPOTHALAMIC ASTROCYTES FROM RAT PUPSAndreia Joaquim (1) - Cideli De Paula Coelho (1) - Maria De Fátima Monteiro Martins (1) - Elizabeth Teodorov (2) Eduardo Fernandes Bondan (1) - Leoni Vilano Bonamin (1) - Maria Martha Bernanrdi (1)

University Paulista, Department Of Veterinary Medicine, São Paulo, Brazil (1) - Federal University Of Abc, Mathematics, Computing And Cognition Center, São Paulo, Brazil (2)

18 - PROPENTOFYLLINE DECREASES GFAP IMMUNOREACTIVITY IN ASTROCYTES AFTER GLIOTOXIC INJURY IN THE RAT BRAINSTEMEduardo Fernandes Bondan - Dossa Pietro Domingues Department Of Environmental And Experimental Pathology, University Paulista, São Paulo, Brazil

45 - PROPENTOFYLLINE DECREASES THE PRODUCTION OF TNF-ALPHA AND IL-1BETA IN THE RAT BRAINSTEM AFTER A GLIOTOXIC INJURY INDUCED BY ETHIDIUM BROMIDEEduardo Fernandes Bondan University Paulista, Department Of Veterinary Medicine, São Paulo, Brazil

19 - PROPENTOFYLLINE INHIBITS LIPID PEROXIDATION AND IMPROVES OLIGODENDROCYTE REMYELINATION FOLLOWING GLIOTOXIC INJURY IN THE RAT BRAINSTEMEduardo Fernandes Bondan (1) - Deborah Eileen Menezes Baliellas (2) - Caio Fernando Monteiro Gimenez (2) - Maria De Fátima Monteiro Martins (2) - Alvaro Augusto Feitosa Pereira (2) - Marcelo Paes Barros (2) - Sandra Castro Poppe (3)

Department Of Environmental And Experimental Pathology; University Paulista, Department Of Veterinary Medicine, University Cruzeiro Do Sul, São Paulo, Brazil (1) - Department Of Veterinary Medicine, University Cruzeiro Do Sul, São Paulo, Brazil (2) Department Of Veterinary Medicine, University Cruzeiro Do Sul, University Paulista, São Paulo, Brazil (3)

47 - EPHRIN B1 AND B2 ARE ESSENTIAL FOR THE PATHOGENICITY AND MIGRATION CAPACITY OF TH17 CELLS IN EAE AND MSBieke Broux - Luo Hongyu - Soufiane Ghannam - Catherine Larochelle - Wei Jin - Yan Hu - Xuehai Wang Yujia Wang - Jianping Wu - Alexandre Prat Crchum, Université De Montreal, Montreal, Canada

407 - CHARACTERIZATION OF TH17 CELLS IN MULTIPLE SCLEROSIS PATIENTS AND HEALTHY CONTROLSUlrike Bühler - René Gollan - Patrick Belikan - Frauke Zipp - Volker Siffrin Department Of Neurology, Johannes Gutenberg University, Mainz, Germany

138 - TIM-3 AND PD-1: REGULATORS OF ADAPTIVE IMMUNITY IN MULTIPLE SCLEROSISJoachim Burman (1) - Emma Svensson (2) - Moa Fransson (2) - Angelica Loskog (2) - Sara Mangsbo (2)

Department Of Neuroscience, Uppsala University, Uppsala, Sweden (1) - Department Of Immunology, Genetics And Pathology, Uppsala University, Uppsala, Sweden (2)

299 - ACHIEVING SPECIFICITY IN THE GLIAL CELL RESPONSE TO THE GP130 CYTOKINESMeng-ping Hsu (1) - Ricardo Frausto (1) - Stefan Rose-john (2) - Iain L. Campbell (1)

School Of Molecular Bioscience, University Of Sydney, Sydney, Australia (1) - Department Of Biochemistry, University Of Kiel, Kiel, Germany (2)

431 - GUT DYSBIOSIS AFFECTS EARLY INFLAMMATORY BRAIN RESPONSE TO THEILER’S MURINE ENCEPHALOMYELITIS VIRUS INFECTIONFrancisco J Carrillo-salinas (1) - Ana Feliú (1) - Miriam Mecha (1) - Leyre Mestre (2) - Antonio Alcamí (2) - Carmen Espejo (3) Xavier Montalban (4) - Jose Carlos Álvarez-carmeño (5) - Luisa María Villar (5) - Carmen Guaza (1)

Neuroimmunology Group, Instituto Cajal, Csic, Madrid, Spain (1) - Centro De Biología Molecular Severo Ochoa, Csic-uam, Madrid, Spain (2) - Servei De Neurologia-neuroimmunologia. Centre D’esclerosi Múltiple De Catalunya (cemcat), Vall D›hebron Institut De Recerca (vhir), Hospital Universitari Vall D›hebron, Barcelona; Universitat Autònoma De Barcelona, 08193 Bellaterra (cerdanyola) (3) Servei De Neurologia-neuroimmunologia. Centre D’esclerosi Múltiple De Catalunya (cemcat), Vall D›hebron Institut De Recerca (vhir), Hsopital Universitari Vall D›hebron, Barcelona; Universitat Autònoma De Barcelona, 08193 Bellaterra (cerdanyola) (4) Departments Of Neurology And Immunology, Hospital Universitario Ramón Y Cajal, Madrid, Spain (5)



208 - FASUDIL AMELIORATES DISEASE PROGRESSION IN EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS, ACTING POSSIBLY THROUGH IMMUNOMODULATION EFFECTChun-yun Liu (1) - Shang-de Guo (1) - Jie-zhong Yu (1) - Yan-hua Li (1) - Hui Zhang (1) - Zhi Chai (2) - Qing Wang (2) Ling Feng (1) - Jian-jun Huang (3) - Qian-jin Feng (2) - Bao-guo Xiao (4) - Cun-gen Ma (2)

Institute Of Brain Science, Department Of Neurology, Medical School, Shanxi Datong University, Datong, China (1) - “2011” Collaborative Innovation Center/department Of Encephalopathy And National Major Clinical Department Of Ministry Of Health, Shanxi University Of Traditional Chinese Medicine, Taiyuan, China (2) - Department Of Neurosurgery, First Hospital, Datong Coalmine Group, Datong, China (3) - Institute Of Neurology, Huashan Hospital, Institutes Of Brain Science And State Key Laboratory Of Medical Neurobiology, Fudan University, Shanghai, China (4)

397 - DISSECTING THE ROLE OF ALZHEIMER’S DISEASE SUSCEPTIBILITY LOCI IN PRIMARY HUMAN MONOCYTES: A COMPLEX INTERPLAY BETWEEN TREM1, TREM2 AND CD33Gail Chan Center For Neurologic Diseases, Brigham And Women’s Hospital, Boston, Ma, United States

531 - CHARACTERIZATION OF MCAM CONTRIBUTION TO NEUROINFLAMMATION USING A NEW MURINE KNOCKOUT MODELMarc Charabati Centre De Recherche Du Centre Hospitalier De L’université De Montréal (crchum), Université De Montréal, Montreal, Canada

226 - INFLUENCE OF EFFECTOR MOLECULES RELEASED BY TH1 AND TH17 CELLS ON GLIAL CELLSPrajeeth Chittappen Kandiyil (1) - Julius Kornisch (1) - Reza Khorooshi (2) - Henrik Toft-hansen (2) - Kirsten Löhr (3) Trevor Owens (2) - Jochen Huehn (3) - Martin Stangel (1)

Clinical Neuroimmunology And Neurochemistry, Department Of Neurology, Hannover Medical School, Hannover, Germany (1) Neurobiology, Institute Of Molecular Medicine, University Of Southern Denmark, Odense, Denmark (2) - Experimental Immunology, Helmholtz Centre For Infection Research, Braunschweig, Germany (3)

246 - THE IMPACT OF NEUROINFLAMMATION ON TAU PATHOLOGY IN HEALTHY AGING AND NEURODEGENERATIONAlexander. W. Collcutt - Jessica. L. Teeling - Ayodeji. A. Asuni Centre For Biological Sciences, University Of Southampton, Southampton, United Kingdom

367 - FINGOLIMOD MAY SUPPORT NEUROPROTECTION VIA BLOCKADE OF ASTROCYTE S1P AND CYTOKINE SIGNALING CASCADES IN MULTIPLE SCLEROSISEmanuela Colombo (1) - Marco Di Dario (1) - Eleonora Capitolo (1) - Linda Chaabane (1) - Jia Newcombe (2) Gianvito Martino (1) - Cinthia Farina (1)

Institute Of Experimental Neurology (inspe), San Raffaele Scientific Institute, Milan, Italy (1) - Neuroresource, Ucl Institute Of Neurology, London, United Kingdom (2)

102 - SHEDDING MICROVESICLES RELEASED BY A HUMAN MICROGLIAL CELL LINE (CHME-5): A GOOD PLATFORM FOR STUDYING THE BIOLOGY OF THE SYSTEM.Federico Colombo (1) - Annamaria Finardi (2) - Gabriella Racchetti (2) - Roberto Furlan (2)

San Raffaele Scientific Institute, Università Vita-salute San Raffaele, Milano, Italy (1) San Raffaele Scientific Institute, Ospedale San Raffaele, Milano, Italy (2)

420 - NEUTROPHILS INDUCE ALZHEIMER’S-LIKE DISEASE VIA LFA-1-INTEGRIN AND NEUTROPHIL EXTRACELLULAR TRAPSElena Zenaro (1) - Enrica Pietronigro (1) - Vittorina Della Bianca (1) - Gennj Piacentino (1) - Alessio Montresor (1) Ermanna Turano (2) - Bruno Bonetti (2) - Gabriela Constantin (1)

Department Of Pathology And Diagnostics, University Of Verona, Verona, Italy (1) - Department Of Neurological Sciences, University Of Verona, Verona, Italy (2)

484 - GENE EXPRESSION ANALYSIS OF HISTAMINE RECEPTORS IN PERIPHERAL BLOOD MONONUCLEAR CELLS FROM CLINICALLY-ISOLATED SYNDROME AND MULTIPLE SCLEROSIS PATIENTSMassimo Costanza (1) - Marco Di Dario (2) - Cinthia Farina (2) - Rosetta Pedotti (1)

Neuroimmunology And Neuromuscular Disorder Unit, Neurological Institute Foundation Irccs C. Besta, Milan, Italy (1) - Institute Of Experimental Neurology (inspe), San Raffaele Scientific Institute, Milan, Italy (2)

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Scientific Program

573 - INFLAMMATION-INDUCED DEPRESSION: EVIDENCE AND MECHANISMSRobert Dantzer - Elisabeth Vichaya - Adam Walker Md Anderson Cancer Center, University Of Texas, Houston, United States

499 - PERSISTENT ACIDOSIS AFFECTS ELECTROPHYSIOLOGICAL TRANSMISSION AND SYNAPTIC HOMEOSTASIS OF NEURONAL NETWORKSRoberta De Ceglia (1) - Linda Chaabane (1) - Emilia Biffi (2) - Andrea Brgamaschi (1) - Giancarlo Ferrigno (2) - Stefano Amadio (3) - Ubaldo Del Carro (3) - Stefano Taverna (4) - Giancarlo Comi (5) - Veronica Bianchi (6) - Patrizia D’adamo (6) Gianvito Martino (1) - Andrea Menegon (7) - Luca Muzio (1)

Neuroimmunolgy Unit, Institute Of Experimental Neurology (inspe), Division Of Neuroscience, San Raffaele Scientific Institute, Milan, Italy (1) - Neuroengineering And Medical Robotics Laboratory, Department Of Electronics, Information And Bioengineering, Politecnico Di Milano, Milan, Italy (2) - Neurophysiology Unit, Division Of Neuroscience, San Raffaele Scientific Institute, Milan, Italy (3)

Department Of Neuroscience And Brain Technologies, Istituto Italiano Di Tecnologia, Genoa, Italy (4) - Department Of Neurology, Institute Of Experimental Neurology (inspe), Vita Salute San Raffaele University, Milan, Italy (5) - Dulbecco Telethon Institute, Division Of Neuroscience, San Raffaele Scientific Institute, Milan, Italy (6) - Advanced Light And Electron Microscopy Bio-imaging Centre, Experimental Imaging Centre, San Raffaele Scientific Institute, Milan, Italy (7)

416 - CYTOKINE RELEASE INHIBITOR DRUG, CRID3, INHIBITS THE NLRP3 INFLAMMASOME IN GLIA.Colin Dempsey (1) - Rebecca Coll (2) - Avril Robertson (3) - Matthew Cooper (3) - Luke O’neill (2) - Marina Lynch (1)

Trinity College Institute Of Neuroscience, University Of Dublin, Trinity College, Dublin, Ireland (1) - Trinity Biomedical Sciences Institute, University Of Dublin, Trinity College, Dublin, Ireland (2) - Institute For Molecular Bioscience, University Of Queensland, Brisbane, Australia (3)

637 - IN THE SEARCH FOR MOLECULAR HALLMARKS OF NEUROINFLAMMATION IN BRAIN DISEASESRichard Reynolds (1) - Owain W Howell (2) - Roberta Magliozzi (3) - David T. Dexter (1) - Pascal Durrenberger (1)

Imperial College London, Division Of Brain Sciences, Hammersmith Campus, Burlington Danes Building, Du Cane Road, London, United Kingdom (1) - Swansea University, Department Of Neurology And Molecular Neuroscience, Institute Of Life Sciences, Swansea, United Kingdom (2) - University Of Rome, Department Of Cell Biology And Neuroscience, Istituto Superiore Di Sanita, Rome, Italy (3)

322 - ROLE OF EARLY ACTIVATED MICROGLIA DURING ONSET OF AUTOIMMUNE OPTIC NEURITISRichard Fairless - Sarah K. Williams - Aleksandar Stojic - Ricarda Diem Department Of Neuro-oncology, University Of Heidelberg, Heidelberg, Germany

411 - NEW INSIGHTS ABOUT ANKRD55 IN THE EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS MODEL OF MULTIPLE SCLEROSIS Ana Feliú (1) - Miriam Mecha (1) - Francisco Javier Carrillo-salinas (1) - Nerea Ugidos (2) - Koen Vandenbroeck (3) Carmen Guaza (1)

Csic, Cajal Institute, Madrid, Spain (1) - Upv/ehu, University Of The Basque Country, Leioa, Spain (2) - Upv/ehu, University Of The Basque Country. Ikerbasque, Basque Foundation Of Science, Leioa. Bilbao, Spain (3)

483 - LACK OF NG2 EXPRESSION ON IMMUNE CELLS AND OLIGODENDROCYTES PROGENITOR CELLS MODULATES EAE PHENOTYPE Giovanni Ferrara (1) - Sara Morando (1) - Mariella Errede (2) - Francesco Girolamo (2) - Valentina Boldrin (3) - Simona Casazza (1) - Nicolò Panini (3) - Eugenio Erba (3) - Roberto Perris (4) - Caterina Bendotti (3) - Tiziana Mennini (3) Livia Garzetti (5) - Roberto Furlan (5) - Nicole Kerlero De Rosbo (1) - Daniela Virgintino (2) - Antonio Uccelli (1)

Department Of Neurosciences, Rehabilitation Ophthalmology, Genetics And Maternal-infantile Sciences,, University Of Genoa, Genova, Italy (1) - Department Of Basic Medical Sciences, Human Anatomy And Histology Unit, University Of Bari School Of Medicine, University Of Bari, Bari, Italy (2) - Department Of Biochemistry And Molecular Pharmacology., Mario Negri Institute, Milan, Italy (3) Department Of Genetics, Microbiology And Anthropology,, University Of Parma, Parma, Italy (4) - Institute Of Experimental Neurology, Division Of Neuroscience, San Raffaele Scientific Institute, Milan, Italy (5)

448 - EARLY IMMUNE RESPONSE IN MPTP -INDUCED NEUROINFLAMMATION IN THE MOUSE MYENTERIC PLEXUS AND CENTRAL NERVOUS SYSTEMCatherine Fontaine-lavallée (1) - Benoît Aubé (1) - Mélissa Côté (1) - Steve Lacroix (2) - Denis Soulet (3)

Centre De Recherche Du Chu De Québec - Pavillon Chul, Laval University, Quebec, Canada (1) - Faculté De Médecine, Département De Médecine Moléculaire, Laval University, Quebec, Canada (2) - Faculté De Médecine, Département De Psychiatrie Et Neuroscience, Laval University, Quebec, Canada (3)



34 - THE ROLE OF REFLEX CONTROL OF IMMUNITY IN THE ANTICONVULSIVE EFFECTS OF VAGUS NERVE STIMULATIONFederica Frigerio - Mattia Maroso - Teresa Ravizza - Valentina Iori - Alberto Pauletti - Annamaria Vezzani Department Of Neuroscience, Irccs-mario Negri Institute For Pharmacological Research, Milan, Italy

71 - DICAM: A NOVEL MOLECULAR EFFECTOR IN NEUROINFLAMMATIONSoufiane Ghannam - Jorge Ivan Alvarez - Hania Kebir - Lyne Bourbonnière - Alexandre Prat (1)

Crchum, Universite De Montreal, Montreal, Canada (1)

311 - POSSIBLE ROLE OF MIRNAS IN THE MODULATION OF NEUROINFLAMMATION BY MESENCHYMAL STEM CELLSDebora Giunti - Benedetta Parodi - Chiara Marini - Nicole Kerlero De Rosbo - Antonio Uccelli Department Of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal And Child Health, University Of Genoa, Genoa, Italy

150 - TWO-PHOTON MICROSCOPY AND NEUROINFLAMMATION: CROSSTALK BETWEEN T CELLS AND NEURONSRene Gollan - Ulrike Bühler - Catherine Larochelle - Frauke Zipp - Volker Siffrin Neurology Department, Johannes Gutenberg University Medical Center, Mainz, Germany

203 - MYELIN SPECIFIC T CELLS INDUCE INFLAMMASOME ACTIVATION IN MICROGLIA IN ZONES OF AXONAL DEGENERATIONManuela Marion Grebing (1) - Helle Hvilsted Nielsen (2) - Christina Fenger (1) - Bettina Hjelm Clausen (1) - Christian Ulrich Von Linstow (1) - Katrine Tækker Jensen (1) - Martin Söderman (1) - Kate Lykke Lambertsen (1) - Mads Thomassen (3) Torben A. Kruse (3) - Bente Finsen (1)

Institute For Molecular Medicine, University Of Southern Denmark, Odense C, Denmark (1) - Department Of Neurology, Odense University Hospital, Odense C, Denmark (2) - Department Of Clinical Genetics, Odense University Hospital, Odense C, Denmark (3)

522 - THE PATHOPHYSIOLOGICAL ROLE OF CYTOTOXIC CD8 T CELLS IN SUSAC SYNDROMEUrvashi Bhatia - Tilman Schneider-hohendorf - Anita Posevitz-fejfar - Nicholas Schwab - Sven G. Meuth Heinz Wiendl - Ilka Kleffner - Catharina C. Gross Department Of Neurology, University Hospital Münster, Münster, Germany

106 - IMPACT OF MINOCYCLINE AND ESTABLISHED MS MEDICATIONS ON EMMPRIN, A NEW FACTOR IMPLICATED IN MS IMMUNOPATHOGENESISJennifer N Hahn - Janet Wang - Claudia Silva - V. Wee Yong Hotchkiss Brain Institute, University Of Calgary, Calgary, Canada

599 - NEUROPROTECTION BY BLOCKING CXCR2 AFTER CEREBRAL ISCHEMIA IN HYPERCHOLESTEROLEMIC MICEJosephine Herz (1) - Pascal Sabellek (2) - Dirk M. Hermann (2) - Thorsten R. Doeppner (2)

Department Of Neurology And Department Of Pediatrics I, University Hospital Essen, Essen, Germany (1) - Department Of Neurology, University Hospital Essen, Essen, Germany (2)

52 - INVESTIGATING THE ROLE OF CYSTATIN C IN EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS.Vahid Hoghooghi (1) - Shalina S Ousman (2)

Faculty Of Medicine, Department Of Neuroscience, University Of Calgary, Calgary, Canada (1) - Faculty Of Medicine, Department Of Clinical Neurosciences, University Of Calgary, Calgary, Canada (2)

153 - SODIUM CHLORIDE-HIGH DIET PROMOTES PRO-INFLAMMATORY MACROPHAGE ACTIVATION AND AGGRAVATES CENTRAL NERVOUS SYSTEM AUTOIMMUNITYStephanie Hucke (1) - Melanie Eschborn (1) - Annika Engbers (1) - Heinz Wiendl (1) - Luisa Klotz (1)

Department Of Neurology, University Of Muenster, Muenster, Germany (1)

507 - THE BILE ACID RECEPTOR FXR CONTROLS CNS AUTOIMMUNITY IN AN IL-10-DEPENDENT FASHIONStephanie Hucke (1) - Martin Herold (1) - Marie Liebmann (1) - Anita Posevitz-fejfar (1) - Tanja Kuhlmann (2) Heinz Wiendl (1) - Luisa Klotz (1)

Department Of Neurology, University Hospital Münster, Münster, Germany (1) - Institute Of Neuropathology, University Hospital Münster, Münster, Germany (2)

53

Scientific Program

265 - IMMUNE COMPLEXES AND LIPOPOLYSACCHARIDE INDUCE MICROGLIAL ACTIVATION AND RETINAL INFLAMMATION: IMPLICATIONS FOR AGE-RELATED MACULAR DEGENERATIONPaul Ibbett (1) - Salome Murinello (1) - Andrew J. Lotery (2) - V. Hugh Perry (1) - Jessica L. Teeling (1)

Centre For Biological Sciences, University Of Southampton, Southampton, United Kingdom (1) - Clinical Neurosciences, University Of Southampton, Southampton, United Kingdom (2)

207 - INFLAMMATORY RESPONSES AND PLAQUE DEPOSITION IN EARLY STAGE ALZHEIMER’S PATHOLOGY IN MICELaura Ilkjær - Alicia Babcock - Christa Løth Myhre - Bente Fiinsen Institute Of Molecular Medicine, University Of Southern Denmark, Odense, Denmark

268 - LEUKEMIA INHIBITORY FACTOR SHIFTS THE IMMUNE BALANCE TOWARDS REGULATORY T CELLSKris Janssens (1) - Chris Van Den Haute (2) - Veerle Baekelandt (2) - Jack Van Horssen (3) - Bart Vanwijmeersch (1) Piet Stinissen (1) - Jerome Hendriks (1) - Helena Slaets (1) - Niels Hellings (1)

Biomedical Research Instistute, Hasselt University, Diepenbeek, Belgium (1) - Laboratory For Neurobiology And Gene Therapy, Katholieke Universiteit Leuven, Leuven, Belgium (2) - Department Of Molecular Cell Biology And Immunology, Vu University Medical Center, Amsterdam, Netherlands (3)

430 - FUNCTIONAL ANALYSES OF TRANSMIGRATED MONOCYTE-DERIVED CD123+ DENDRITIC CELLS ACROSS THE INFLAMED BLOOD-BRAIN BARRIER ENDOTHELIUMTakahiro Katayama - Akiko Nakano - Igal Ifergan - Hania Kebir - Marc-andré Lécuyer - Catherine Larochelle Jorge Ivan Alvarez - Alexandre Prat Chum Research Center, Université De Montréal, Montréal, Canada

534 - IBUDIDAST INHIBITS IL-17Kiyokazu Kawabe - Masaru Yanagihashi - Ken Ikeda - Yasuo Iwasaki Department Of Neurology, Toho University Omori Medical Centre, Tokyo, Japan

259 - DIETARY TRYPTOPHAN IS REQUIRED FOR CNS INFILTRATION OF ENCEPHALITOGENIC T CELLSMelanie Keil (1) - Maren Paulsen (2) - Jana Sonner (1) - Iris Oezen (1) - Theresa Schumacher (1) - Jürgen G. Okun (3) Albrecht Stenzinger (4) - Philip Rosenstiel (2) - Wolfgang Wick (5) - Michael Platten (5)

Ccu Neuroimmunology And Brain Tumor Immunology, German Cancer Research Center, Heidelberg, Germany (1) - Institute Of Clinical Molecular Biology, University Kiel, Kiel, Germany (2) - Ccu Metabolic Center, Children’s Hospital, Heidelberg, Germany (3) - Department Of Pathology, University Heidelberg, Heidelberg, Germany (4) - Department Of Neurooncology, University Hospital Heidelberg, Heidelberg, Germany (5)

535 - REGULATION OF RE-MYELINATION AND/OR MYELIN REPAIR BY METHYL CPG BINDING PROTEIN 2 AND BRAIN DERIVED NEUROTROPHIC FACTOR IN AN EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS MODEL OF MULTIPLE SCLEROSISTina Khorshid Ahmad - Crystal Acosta - Claudia Cortes - Michael Namaka University Of Manitoba, Faculty Of Pharmacy, Winnipeg, Canada

362 - CLINICAL AND RADIOLOGICAL CHARACTERITICS OF SIX PATIENTS WITH TUMEFACTIVE DEMYELINATING LESIONSMunire Kilinc Toprak - Seda Kibaroglu - Eda Derle - Ulku Sibel Benli Baskent University Faculty Of Medicine, Baskent University Faculty Of Medicine, Ankara, Turkey

493 - TILTING THE BALANCE OF M1/M2 MICROGLIAL PHENOTYPES: INHIBITION OF EZH2 LEADS TO DECREASED M1 AND ENHANCED M2 PHENOTYPEEdward Koellhoffer - Rodney Ritzel - Jeremy Grenier - Louise Mccullough University Of Connecticut Health Center, University Of Connecticut Health Center, Farmington, United States

131 - AMELIORATING EFFECTS OF HCA 3551, ALPHA 4 INTEGRIN ANTAGONIST, ON THEILER’S MURINE ENCEPHALOMYELITIS VIRUS (TMEV) -INDUCED DEMYELINATING DISEASEYuta Hirano (1) - Kunitoshi Kobayashi (1) - Hiroki Tomiki (1) - Motoki Ichikawa (2) - Chung-sung Koh (3)

Department Of Biomedical Laboratory Sciences, Graduate School Of Medicine, Shinshu University, Matsumoto, Japan (1) - School Of Health Sciences, Shinshu University, Matsumoto, Japan (2) - Department Of Biomedical Laboratory Sciences, School Of Health Sciences, Shinshu University, Matsumoto, Japan (3)



538 - DIFFERENTIAL PHOSPHORYLATION OF ALPHA B-CRYSTALLIN IN ASTROCYTES AND OLIGODENDROCYTES SUGGESTS A DIVERSITY IN ITS BIOLOGICAL FUNCTIONHedwich F Kuipers (1) - Jane Yoon (1) - Johannes Winderl (1) - Jack Van Horssen (2) - May H Han (1) - Theo D Palmer (1) Lawrence Steinman (1)

Stanford University, Stanford University Medical Center, Stanford, Ca, United States (1) - Vu University, Vu University Medical Center, Amsterdam, Netherlands (2)

566 - PHARMACO-MODULATION OF INFLAMMATORY RESPONSE INDUCED BY THE KV1.3 CHANNEL LIGANDSFatima Laraba-djebari - Zahida Taibi-djennah Usthb, Faculty Of Biological Sciences, Laboratory Of Cellular And Molecular, Usthb, Algiers, Algeria

254 - NEUROINFLAMMATION MEDIATED BY NF-KAPPAB ACTIVATION IN ASTROCYTES INDUCES NON-CELL-AUTONOMOUS PURKINJE CELL DEGENERATIONMichael Lattke (1) - Alexander Magnutzki (1) - Paul Walther (2) - Boris Ferger (3) - Thomas Wirth (1) - Bernd Baumann (1)

Institute Of Physiological Chemistry, Ulm University, Ulm, Germany (1) - Central Facility For Electron Microscopy, Ulm University, Ulm, Germany (2) - Cns Diseases Research, Boehringer Ingelheim Pharma Gmbh & Co. Kg, Biberach A.d. Riss, Germany (3)

280 - MICROGLIA PHENOTYPES IN THE SPINAL CORDS OF AGING AND OBESE MICE: COMORBIDITY WITH ALTERED SENSORY RESPONSESeunghwan Lee - Yasi Wu - Xiang Qun Shi - Ji Zhang The Alan Edwards Centre For Research On Pain, Mcgill University, Montreal, Canada

458 - MESENCHYMAL STEM CELLS OVEREXPRESSING IL-13 DECREASE LESION SIZE AND DEMYELINATION AFTER SPINAL CORD INJURYDearbhaile Dooley (1) - Evi Lemmens (1) - Tim Vangansewinkel (1) - Stefanie Lemmens (1) - Nathalie De Vocht (2) Debbie Le Blon (2) - Peter Ponsaerts (2) - Sven Hendrix (1)

Biomedical Research Institute, Hasselt University, Diepenbeek, Belgium (1) - Laboratory Of Experimental Hematology, Vaccine And Infectious Disease Institute (vaxinfectio), University Of Antwerp, Antwerp, Belgium (2)

297 - MICROGLIAL HETEROGENEITY IN A MOUSE MODEL OF AMYOTROPHIC LATERAL SCLEROSIS: A SINGLE-CELL TRANSCRIPTOME ANALYSISCoral-ann Lewis (1) - Preetheeban Thavaneetharajah (1) - Charles Krieger (2) - Fabio Rossi (1)

Biomedical Research Centre, University Of British Columbia, Vancouver, Canada (1) - Department Of Biomedical Physiology And Kinesiology, Simon Fraser University, Burnaby, Canada (2)

341 - THE NUCLEAR RECEPTOR NUR77 RESTRICTS T CELL RESPONSES AND LIMITS CENTRAL NERVOUS SYSTEM AUTOIMMUNITYMarie Liebmann (1) - Stephanie Hucke (1) - Tanja Kuhlmann (2) - Heinz Wiendl (1) - Luisa Klotz (1)

Department Of Neurology, University Of Muenster, Muenster, Germany (1) - Department Of Neuropathology, University Of Muenster, Muenster, Germany (2)

162 - UP-REGULATION OF DORSAL ROOT GANGLIA BDNF AND TRKB RECEPTOR IN INFLAMMATORY PAINYa-tin Lin (1) - Long-sun Ro (2) - Hung-li Wang (1) - Jin-chung Chen (1)

Graduate Institute Of Biomedical Sciences, Chang Gung University, Taoyuan, Taiwan, Province Of China (1) - Department Of Neurology, Chang Gung Memorial Hospital, Taoyuan, Taiwan, Province Of China (2)

526 - DYSREGULATION OF THE HOMEOSTATIC MICROGLIA SIGNATURE IN GERM-FREE MICECharlotte Madore (1) - Zain Fanek (1) - David Greco (1) - Olga Kinner (1) - Vladimir Yeliseyev (2) - Lynn Bry (2) Oleg Butovsky (1)

Center For Neurologic Diseases, Brigham And Women’s Hospital/harvard Medical School, Boston, United States (1) Department Of Pathology, Brigham And Women’s Hospital/harvard Medical School, Boston, United States (2)

528 - HIV-1 VPR ACTIVATES THE NLRP3 INFLAMMASOME IN PRIMARY HUMAN MICROGLIAManmeet Mamik (1) - Jesse Chisholm (1) - Brienne Mckenzie (2) - John Walsh (2) - Christopher Power (1)

Department Of Medicine, University Of Alberta, Edmonton, Canada (1) - Department Of Medical Microbiology And Immunology, University Of Alberta, Edmonton, Canada (2)

55

Scientific Program

325 - DIFFERENTIAL POLARIZATION BETWEEN RESIDENT MICROGLIA AND BRAIN INFILTRATING MACROPHAGES IN MOUSE MODELS OF ALZHEIMER’S DISEASEElodie Martin - Bertrand Fontaine - Cecile Delarasse Brain And Spine Institute (icm), Hopital Pitié-salpêtrière, Paris, France

376 - THE CENTRAL NERVOUS SYSTEM MICROENVIRONMENT IMPRINTS MICROGLIAL INABILITY TO SWITCH FROM PRO- TO ANTI- INFLAMMATORY PHENOTYPEOrit Matcovitch (1) - Merav Cohen (1) - Eyal David (2) - Zohar Barnett-itzhaki (2) - Hadas Keren-shaul (2) Ronnie Blecher-gonen (2) - Diego Adhemar Jaitin (2) - Antonio Sica (3) - Ido Amit (2) - Michal Schwartz (1)

Department Of Neurobiology, Weizmann Institute Of Science, Rehovot, Israel (1) - Department Of Immunology, Weizmann Institute Of Science, Rehovot, Israel (2) - Humanitas Clinical And Research Center, Rozzano, Milan, Italy., Discaff, University Of Piemonte Orientale A. Avogadro, Novara, Italy (3)

579 - PERIPHERAL INFLAMMATION AFFECTS THE CENTRAL NERVOUS SYSTEM AND BIOLOGY OF THE BRAINAlison Mccoll (1) - Carolyn Thomson (1) - Gerard Graham (1) - Jonathan Cavanagh (2)

Institute Of Infection, Immunity & Inflammation, University Of Glasgow, Glasgow, United Kingdom (1) - Institute Of Neuroscience & Psychology, University Of Glasgow, Glasgow, United Kingdom (2)

82 - ACTIVATION OF MULTIPLE INFLAMMASOMES WITHIN THE CENTRAL NERVOUS SYSTEM DURING EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS AND MULTIPLE SCLEROSISBrienne Mckenzie (1) - Stacey Reinke (2) - William Branton (2) - Jian-qiang Lu (3) - Christopher Power (2)

Department Of Medical Microbiology And Immunology, University Of Alberta, Edmonton, Canada (1) Department Of Medicine, University Of Alberta, Edmonton, Canada (2) - Department Of Laboratory Medicine And Pathology, University Of Alberta, Edmonton, Canada (3)

351 - FTY720 PROTECTS AGAINST PATHOLOGY ASSOCIATED WITH INFECTION-INDUCED T CELL MIGRATION INTO THE BRAIN IN A MOUSE MODEL OF ALZHEIMER’S DISEASE Roisin Mcmanus (1) - Mieszko Wilk (2) - Sarah Higgins (2) - Kingston Mills (2) - Marina Lynch (1)

Trinity College Institute Of Neuroscience, Trinity College Dublin, Dublin, Ireland (1) - School Of Biochemistry And Immunology, Trinity College Dublin, Dublin, Ireland (2)

541 - NEW PLAYERS FOR THE ALTERNATIVE ACTIVATION OF MICROGLIA: BEYOND ARGINASE-1Miriam Mecha (1) - Ana Feliú (1) - Francisco Javier Carrillo-salinas (1) - Ainhoa Rueda-zubiaurre (2) Silvia Ortega-gutierrez (2) - Maria Luz López Rodríguez (2) - Carmen Guaza (1)

Instituto Cajal, Csic, Madrid, Spain (1) - Departamento De Química Orgánica I, Facultad De Ciencias Químicas, Universidad Complutense De Madrid, Madrid, Spain (2)

267 - THE EFFECTS OF FUMARIC ACID ESTERS ON INFLAMMATORY RESPONSES IN HUMAN MICROGLIA.Mackenzie Michell-robinson (1) - Craig Moore (2) - Jack Antel (1)

Montreal Neurological Institute, Mcgill University, Montreal, Canada (1) - Health Sciences Centre, Memorial University, St. John’s, Canada (2)

375 - SERUM FROM APP/PS1 MICE NEGATIVELY IMPACTS ON BBB INTEGRITY LEADING TO ENHANCED MACROPHAGE INFILTRATION AND EXACERBATION OF INFLAMMATIONAedin M. Minogue (1) - Raasay S. Jones (1) - James P. Barrett (1) - Marina A. Lynch (1)

Trinity College Institute Of Neuroscience, Trinity College Dublin, Dublin, Ireland (1)

51 - IMPAIRMENT OF THALAMO-CORTICAL NETWORK ACTIVITIES IN ANIMAL MODELS OF MULTIPLE SCLEROSIS Venu Narayanan (1) - Cerina Manuela (1) - Kerstin Göbel (1) - Theimo Daldrup (2) - Patrick Meuth (2) Thomas Seidenbecher (2) - Thomas Budde (2) - Hans-christian Pape (2) - Sven Meuth (1)

Neuropathophysiology, Albert-schweitzer Campus 1, Gebäude A10, 48149 Münster, Germany., Westfälische Wilhelms Universität Münster, Muenster, Germany (1) - Institute For Physiology1, Westfälische Wilhelms Universität Münster, Muenster, Germany (2)

619 - RADICAL ANTIOXIDANTS LIMIT BLOOD-BRAIN BARRIER ACTIVATION AND AMELIORATE DISEASE IN MODELS OF MULTIPLE SCLEROSISSarah Neil - Elena Cavazzi - Negar Farzam-kia - Jacqueline Quandt Brain Research Centre, University Of British Columbia, Vancouver, Canada



66 - SUPPRESSION OF SPINAL CORD INJURY ON HUMAN MESENCHYMAL STEM/PROGENITOR CELLS (MSCS) MEDIATED BY PITUITARY ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE (PACAP)Hirokazu Ohtaki (1) - Tomomi Tsumuraya (1) - Atsushi Sato (1) - Zhifang Xu (1) - Kazuyuki Miyamoto (1) - Jun Watanabe (1) Tomoya Nakamachi (2) - Hitoshi Hashimoto (3) - Seiji Shioda (1)

Department Of Anatomy, Showa University School Of Medicine, Tokyo, Japan (1) - Laboratory Of Regulatory Biology, Graduate School Of Science And Engineering, University Of Toyama, Toyama, Japan (2) - Laboratory Of Molecular Neuropharmacology, Graduate School Of Pharmaceutical Sciences, Osaka University, Osaka, Japan (3)

197 - NORADRENALINE-MEDIATED PROTECTION AGAINST TNF-ALPHA-INDUCED NEURONAL ATROPHYEimear O’neill - Jennifer Day - Thomas Connor - Andrew Harkin Trinity College Institute Of Neuroscience, Trinity College Dublin, Dublin, Ireland

505 - INTERFERON BETA 1A TREATMENT INDUCES THE PRESENCE OF AUTOREACTIVE ANTIBODIES (ARAB) IN PATIENTS WITH RELAPSING-REMITTING MULTIPLE SCLEROSIS (RRMS)Chrysostomos Papastergios (1) - Emmanouil Karamouzos (1) - Ioannis Markakis (1) - Christiana Kaliouli (2) Pappa Eleni (2) - Georgios Gekas (1)

Neurology Clinic, General Hospital Of Nikaia-piraeus “ag. Panteleimon”, Nikaia-piraeus, Greece (1) - Immunology Department, General Hospital Of Nikaia-piraeus “ag. Panteleimon”, Nikaia-piraeus, Greece (2)

313 - MONOMETHYL FUMARATE INHIBITS THE NFKB PATHWAY AND PRO-INFLAMMATORY CYTOKINE EXPRESSION IN MICROGLIA THROUGH HCA2 SIGNALING VIA THE AMPK/SIRT AXISBenedetta Parodi (1) - Christian Cordano (1) - Sara Morando (1) - Alberto Bragoni (1) - Debora Giunti (1) - Cesare Usai (2) Diego Centonze (3) - Nicole Kerlero De Rosbo (1) - Robert H. Scannevin (4) - Antonio Uccelli (1)

Neuroimmunology Unit - Department Of Neurosciences, Ophthalmology And Genetics, University Of Genoa, Genoa, Italy (1) - Institute Of Biophysics, National Research Council, University Of Genoa, Genoa, Italy (2) - Department Of Neurosciences, Tor Vergata University Of Rome, Rome, Italy (3) - Biogen Idec, 14 Cambridge Center, Cambridge, Ma, United States (4)

159 - THE ROLE OF NFATC2 IN CHRONIC AUTOIMMUNE NEUROINFLAMMATIONMagdalena Paterka (1) - Valerie Staudt (2) - Eva Reuter (1) - Frauke Zipp (1) - Tobias Bopp (2)

Department Of Neurology, University Medical Center Mainz, Mainz, Germany (1) - Institute For Immunology, University Medical Center Mainz, Mainz, Germany (2)

247 - THE ROLE OF T CELL-ACTIVATION IN NEUROMYELITIS OPTICA LESION FORMATIONMaria Pohl Department Of Neuroimmunology, Center For Brain Research, Medical University Vienna, Vienna, Austria

68 - OXYSTEROLS PROMOTE ENCEPHALITOGENIC CD4+ T CELLS MIGRATION DURING NEUROINFLAMMATIONFanny Chalmin (1) - Viviane Rochemont (2) - Carla Lippens (2) - Doron Merkler (2) - Stéphanie Hugues (2) - Caroline Pot (1)

Department Of Neurology, Geneva University Hospitals, Geneva, Switzerland (1) - Department Of Pathology And Immunology, Geneva University, Geneva, Switzerland (2)

490 - IFNBETA SECRETED BY MICROGLIA MEDIATES CLEARANCE OF MYELIN DEBRIS ASSOCIATED WITH CNS AUTOIMMUNITYAnn-kathrin Pulm (1) - Magdalena Kocur (1) - Reiner Schneider (2) - Jens Bauer (1) - Sonja Kropp (1) - Micheal Gliem (2) Jens Ingwersen (2) - Judith Alferink (3) - Timour Prozorovski (2) - Orhan Aktas (2) - Stefanie Scheu (1)

Institute Of Medical Microbiology And Hospital Hygiene, Heinrich-heine University, Düsseldorf, Germany (1) - Department Of Neurology, Heinrich-heine Universität, Düsseldorf, Germany (2) - Department Of Psychiatry And Psychotherapy, University Of Muenster, Germany, University Of Münster, Münster (3)

240 - FORMATION OF MENINGEAL TERTIARY LYMPHOID-LIKE STRUCTURES FOLLOWING ACUTE SPINAL CORD INJURY SUPPORTS CHRONIC INFLAMMATION IN THE INJURED CENTRAL NERVOUS SYSTEMCatarina Raposo - Merav Cohen - Michal Schwartz Weizmann Institute Of Science, Department Of Neurobiology, Rehovot, Israel

481 - CHANGES IN MICROGLIAL PROLIFERATION RATE IN GFAP-IL10TG MICE FOLLOWING PERFORANT PATHWAY TRANSECTION Mireia Recasens Torné (1) - Beatriz Almolda (1) - Ian Campbell (2) - Berta Gonzalez (1) - Bernardo Castellano (1)

Department Of Cell Biology, Physiology And Immunology, Institute Of Neurosciences, Autonomous University Of Barcelona, Bellaterra, Spain (1) - 2school Of Molecular Bioscience, University Of Sydney, Nsw, Australia, Sydney, Australia (2)

57

Scientific Program

166 - GESTATIONAL EXPOSURE TO BISPHENOL-A INCREASES SUSCEPTIBILITY OF ADULT MICE TO DEVELOPMENT OF EAE James Rogers (1) - Claudia Silva (1) - Luanne Metz (1) - Olga Kovalchuk (2) - V. Wee Yong (1)

Hotchkiss Brain Institute, University Of Calgary, Calgary, Canada (1) - Department Of Biological Sciences, University Of Lethbridge, Lethbridge, Canada (2)

198 - THE ROLE OF MICROGLIA AND INFLAMMATION IN AN ANIMAL MODEL OF ALSChiara Rossi (1) - Annamaria Finardi (2) - Andrea Cugurra (1) - Andrea Bergamaschi (2) - Roberto Furlan (2) Angelo Quattrini (3) - Giancarlo Comi (4) - Gianvito Martino (2) - Luca Muzio (2)

Neuroimmunology Unit, Division Of Neuroscience , Institute Of Experimental Neurology (inspe), Università Vita Salute San Raffaele, Milano, Italy (1) - Neuroimmunology Unit, Division Of Neuroscience , Institute Of Experimental Neurology (inspe), Ospedale San Raffaele, Milano, Italy (2) - Experimental Pathology Unit, Division Of Neuroscience, Institute Of Experimental Neurology, Ospedale San Raffaele, Milano, Italy (3) - Division Of Neuroscience, Institute Of Experimental Neurology (inspe), Ospedale San Raffaele, Milano (4)

26 - THE NKG2D SIGNALING PATHWAY IS A POSSIBLE THERAPEUTIC TARGET FOR AUTOIMMUNE MYOSITIS.Tobias Ruck - Ali Maisam Afzali - Stefan Bittner - Sven G. Meuth - Heinz Wiendl Department Of Neurology, University Of Münster, Münster, Germany

452 - CHARACTERIZATION OF TETRASPANIN-2 EXPRESSING CELLS IN THE MOUSEChristina Ruland (1) - Julia Patzig (2) - Katharina Lahl (3) - Veronika Lukacs-kornek (4) - Arezoo Fattahi-mehr (1) Stefanie Scheu (5) - Andreas Zimmer (6) - Tanja Kuhlmann (7) - Hauke Werner (2) - Irmgard Förster (8) Tim Sparwasser (9) - Judith Alferink (1)

Department Of Psychiatry, University Hospital Münster, Münster, Germany (1) - Department Of Neurogenetics, Max Planck Institute Of Experimental Medicine, Göttingen, Germany (2) - Laboratory Of Immunology And Vascular Biology, Department Of Pathology, Stanford University School Of Medicine, Stanford, California, United States (3) - Department Of Medicine Ii, Saarland University Medical Center, Homburg, Germany (4) - Institute Of Medical Microbiology And Hospital Hygiene, University Of Düsseldorf, Düsseldorf, Germany (5) - Institute Of Molecular Psychiatry, University Of Bonn, Bonn, Germany (6) - Institute Of Neuropathology, University Hospital Münster, Münster, Germany (7) - Department Of Immunology And Environment, Life & Medical Sciences Institute (limes), University Of Bonn, Bonn, Germany (8) - Institute Of Infection Immunology, Twincore, Centre For Experimental And Clinical Infection Research, Hannover, Germany (9)

405 - RGC-32 REGULATES TGF- BETA INDUCED EXTRACELLULAR MATRIX EXPRESSION IN REACTIVE ASTROCYTESCosmin Tegla (1) - Cornelia Cudrici (1) - Dallas Boodhoo (1) - Alvaro Martin (1) - Adam Sugarman (1) - Jacob Danoff (1) Violeta Rus (2) - Horea Rus (1)

University Of Maryland, School Of Medicine, Dept. Neurology, Baltimore, United States (1) - University Of Maryland, School Of Medicine, Dept. Internal Medicine, Baltimore, United States (2)

205 - AGE-SPECIFIC SUSCEPTIBILITY TO NEUROINFLAMMATION DURING POST-NATAL DEVELOPMENTInês Sá-pereira (1) - Yvonne Couch (1) - Daniel C. Anthony (1) - Helen B. Stolp (2)

Experimental Neuropathology, Department Of Pharmacology, University Of Oxford, Oxford, United Kingdom (1) Centre For The Developing Brain, Department Of Perinatal Imaging & Health, King’s College London, London, United Kingdom (2)

59 - R-FLURBIPROFEN ATTENUATES EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS IN MICEKatja Schmitz (1) - Natasja Debruin (2) - Philipp Bishay (1) - Julia Männich (1) - Annett Häussler (1) - Nerea Ferreirós (1) Jörn Lötsch (1) - Alfred Ultsch (3) - Michael J. Parnham (2) - Gerd Geisslinger (1) - Irmgard Tegeder (1)

Pharmazentrum Frankfurt, Goethe University Hospital, Institute Of Clinical Pharmacology, Frankfurt, Germany (1) - Project Group Translational Medicine And Pharmacology (ime-tmp), Fraunhofer Institute Of Molecular Biology And Applied Ecology, Frankfurt, Germany (2) - Databionics Research Group, University Of Marburg, Frankfurt, Germany (3)

339 - ANTI-NEUROINFLAMMATORY EFFECT OF BUTANOLIC SUBEXTRACT OF CAPPARIS OVATA WATER EXTRACT USED AS AN ALTERNATIVE AND COMPLEMENTARY TREATMENT FOR MULTIPLE SCLEROSISAlaattin Sen (1) - Gulacti Topcu (2) - Ozden Ozgun (1) - Ufuk Kolak (3) - Isil Hacibekiroglu (4) - Gurbet Celik (1) Sevki Arslan (1)

Biology Department, Faculty Of Arts & Sciences, Pamukkale University, Denizli, Turkey (1) - Department Of Pharmacognosy & Phytochemistry, Faculty Of Pharmacy, Bezmialem Vakif University, Istanbul, Turkey (2) - Department Of Analytical Chemistry, Faculty Of Pharmacy, Istanbul University, Istanbul, Turkey (3) - Department Of Analytical Chemistry, Faculty Of Pharmacy, Bezmialem Vakif University, Istanbul, Turkey (4)



117 - ENHANCED LEVELS OF IL-27 AND IL-27R IN THE CENTRAL NERVOUS SYSTEM OF MULTIPLE SCLEROSIS PATIENTSVincent Sénécal (1) - Diane Beauseigle (1) - Raphael Schneider (1) - Craig Moore (2) - Alexandre Prat (1) Jia Newcombe (3) - Samuel Ludwin (4) - Jack P. Antel (2) - Nathalie Arbour (1)

Research Center-chum, Université De Montréal, Montréal, Canada (1) - Montreal Neurological Institute, Mcgill University, Montréal, Canada (2) - Ucl Institute Of Neurology, University College London, London, United Kingdom (3) - Department Of Neuropathology, Queen’s University, Kingston, Canada (4)

451 - PROINFLAMMATORY MONOCYTE PRODUCTION AND DISTRIBUTION ARE MODULATED BY ALPHA7 AND ALPHA9 NICOTINIC ACETYLCHOLINE RECEPTORSAlain Simard (1) - Wei Jiang (2) - Barbara Morley (3)

Department Of Chemistry And Biochemistry And Centre De Formation Médicale Du Nouveau-brunswick, Université De Moncton, Moncton, Canada (1) - Neurology Department, Tianjin Medical University General Hospital, Tianjin, China (2) - Center For Hereditary Communication Disorders, Boys Town National Research Hospital, Omaha, United States (3)

157 - IMPAIRED REMISSION FROM AUTOIMMUNE NEUROINFLAMMATION UPON T CELL-SPECIFIC KNOCKOUT OF THE STRESS KINASE GCN2Jana Sonner (1) - Melanie Keil (1) - Tobias Lanz (1) - Iris Oezen (1) - Theresa Schumacher (1) - Felix Sahm (2) Wolfgang Wick (3) - Michael Platten (3)

Ccu Neuroimmunology And Brain Tumor Immunology, German Cancer Research Center, Heidelberg, Germany (1) - Department Of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany (2) - Department Of Neurooncology, University Hospital Heidelberg, Heidelberg, Germany (3)

112 - ROLE OF 5-LIPOXYGENASE IN THE INFLAMED CNSHong Qiu Department Of Dermatology, University Of California, Sacramento, United States

110 - PLATELETS PROMOTE PATHOGENIC T CELL DIFFERENTIATION IN MS AND EAESarah Christin Starossom (1) - Tatyana Veremeyko (2) - Howard L Weiner (1) - Eugene D. Ponomarev (1)

Center For Neurologic Diseases, Brigham And Womens Hospital, Harvard Medical School, Boston, United States (1) School Of Biomedical Sciences, Chinese University Of Hong Kong, Hong Kong, Hong Kong (2)

264 - CHANGES IN CHONDROITIN SULFATE PROTEOGLYCANS IN EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITISErin L. Stephenson - James A. Rogers - Michael B. Keough - V. Wee Yong Hotchkiss Brain Institute, University Of Calgary, Alberta, Canada

520 - NICOTINE ACETYLCHOLINE RECEPTORS MODULATE BONE MARROW-DERIVED MONOCYTE DIFFERENTIATIONStéphanie St-pierre (1) - Patrick Roy (1) - Wei Jiang (2) - Camille Champigny (1) - Alain R. Simard (1)

Université De Moncton, Université De Moncton, Moncton, Canada (1) - Tianjin Medical University, General Hospital, Tianjin, China (2)

524 - HUMAN B CELL AND GLIAL CELL INTERACTIONS: IMPLICATIONS TO THE COMPARTMENTALIZED CNS INFLAMMATION OF MULTIPLE SCLEROSIS (MS)Hanane Touil (1) - Craig Stephen Moore (2) - Rui Li (2) - Antonia Kobert (2) - Luke Healy (2) - Alexandre Prat (3) Jennifer L. Gommerman (4) - Jack Antel (5) - Amit Bar-or (6)

Montreal Neurological Institut (mni), Mcgill University, Montreal, Canada (1) - Montreal Neurological Institute, Mcgill University, Montreal, Canada (2) - Centre De Recherche Du Centre Hospitalier De L’université De Montreal, Université De Montreal, Montreal, Canada (3) - Department Of Immunology, University Of Toronto,, University Of Toronto, Toronto, Canada (4) - Montreal Neurological Institute, Mcgill University, Montreal, Canada (5) - Montreal Neurological Institut, Mcgill University, Montreal, Canada (6)

193 - EMERGING ROLES FOR NEUROPEPTIDES IN NEURO-IMMUNE REGULATION IN AMYOTROPHIC LATERAL SCLEROSIS: LESSONS FROM THE SUPEROXIDE DISMUTASE 1-G93A MOUSE MODELEberhard Weihe - Cornelia Ringer - Burkhard Schuetz Institute Of Anatomy & Cell Biology, Philipps-university-marburg, Marburg, Germany

59

Scientific Program

61 - POSTOPERATIVE DELIRIUM IN ELDERLY HIP FRACTURE PATIENTS: PREOPERATIVE CSF PROTEOME SUGGESTS A NEUROINFLAMMATORY RESPONSEDunja Westhoff (1) - Joost Witlox (2) - Inge Cm Hoogland (1) - Corneli Van Aalst (3) - Leo Koenderman (3) David J Van Westerloo (4) - Diederik Van De Beek (5) - Willem A Van Gool (6)

Neuroinfection Amsterdam, Academic Medical Center / University Of Amsterdam, Amsterdam, Netherlands (1) Department Of Geriatrics, Medical Center Alkmaar, Alkmaar, Netherlands (2) - Department Of Respiratory Medicine, University Medical Center Utrecht / University Of Utrecht, Utrecht, Netherlands (3) - Department Of Intensive Care Medicine, Leiden University Medical Center / University Of Leiden, Leiden, Netherlands (4) - Neuroinfection Amsterdam, Academic Medical Centerl / University Of Amsterdam, Amsterdam, Netherlands (5) - Department Of Neurology, Academic Medical Center / University Of Amsterdam, Amsterdam, Netherlands (6)

120 - INNATE CELL MODULATOR MIS416 SUPPRESSES CNS DISEASE IN EAEMadeleine White (1) - Gill Webster (2) - Anne La Flamme (1)

School Of Biological Sciences, Victoria University Of Wellington, Wellington, New Zealand (1) - Innate Immunotherapeutics, Innate Immunotherapeutics, Auckland, New Zealand (2)

176 - REDUCED LEVEL OF SIALYLATED IGG ANTIBODY IN THE CSF OF PATIENTS WITH MULTIPLE SCLEROSISTara Curley (1) - Tiffany Pointon (1) - Hayden Collins (1) - Kathryn Dennison (1) - Gina Im (1) - Michael Graner (2) David Wagner (3) - Xiaoli Yu (1)

School Of Medicine, Neurology, University Of Colorado, Aurora, Co, United States (1) - School Of Medicine, Neurosurgery, University Of Colorado, Aurora, Co, United States (2) - School Of Medicine, Webb-waring Center, University Of Colorado, Aurora, Co, United States (3)

572 - ANTI-CD73 ANTIBODIES ARE SUFFICIENT TO PREVENT RATHER THAN TREAT EXPERIMENTAL AUTOIMMUNE NEURITISHongliang Zhang (1) - Wei Wu (2) - Xiujuan Wu (1) - Quo Vadis (3)

Neuroscience Center, Department Of Neurology, The First Hospital Of Jilin University, Changchun, China (1) Department Of Neurosurgery, The First Hospital Of Jilin University, Changchun, China (2) Medical School, Harvard University, Massachusetts, United States (3)

25 - COMPARATIVE STUDY ON FULMINANT AND SPORADIC GUILLAIN-BARRÉ SYNDROME IN NORTHEAST CHINAYing Wang (1) - Guihong Li (2) - Siyu Yang (2) - Xiaoyi Gu (2) - Xinyu Li (2) - Mingyang Liu (2) - Xiujuan Wu (1) Xiaokun Wu (1) - Hongliang Zhang (1)

Neuroscience Center, Department Of Neurology, The First Hospital Of Jilin University, Changchun, China (1) - Norman Bethune Health Science Center, Jilin University, Changchun, China (2)

569 - INDUCING ALTERNATIVELY ACTIVATED MACROPHAGES (M2) AMELIORATE EXPERIMENTAL AUTOIMMUNE NEURITIS IN TOLL-LIKE RECEPTOR 2 DEFICIENT MICEHongliang Zhang (1) - Wei Wu (2) - Xiujuan Wu (1) - Quo Vadis (3)

Neuroscience Center, Department Of Neurology, The First Hospital Of Jilin University, Changchun, China (1) - Department Of Neurosurgery, The First Hospital Of Jilin University, Changchun, China (2) - Medical School, Harvard University, Massachusetts, United States (3)

571 - TOLL-LIKE RECEPTOR 4 DEFICIENCY AMELIORATES EXPERIMENTAL AUTOIMMUNE NEURITIS BY DOWNREGULATING CLASSICALLY ACTIVATED MACROPHAGES (M1)Hongliang Zhang (1) - Wei Wu (2) - Xiujuan Wu (1) - Quo Vadis (3)

Neuroscience Center, Department Of Neurology, The First Hospital Of Jilin University, Changchun, China (1) - Department Of Neurosurgery, The First Hospital Of Jilin University, Changchun, China (2) - Medical School, Harvard University, Massachusetts, United States (3)

TECHNOLOGY TALK TRANSLATION IN MS RESEARCH 16:45 - 17:30 PLENARY ROOM (KONGRESS SAAL)

Chair: Alexander Flügel

16:45 TRANSLATION OF GENETIC FINDINGS IN MS Lars Fugger

60 Day 4 | Wednesday - November 12th


GENERAL MECHANISMS OF INFLAMMATION 08:15 - 09:30 PLENARY ROOM (KONGRESS SAAL)

Chairs: Gianvito Martino, Amit Bar-Or

08:15 MOLECULAR BASIS FOR THE POST-ISCHEMIC INFLAMMATION IN THE BRAIN AKIHIKO YOSHIMURA

08:53 THE ROLE OF DISTINCT EFFECTOR T CELL SUBSETS IN CNS AUTOIMMUNE DISEASE JOAN GOVERMAN


CROSSTALK OF THE IMMUNE AND NERVOUS SYSTEM II 10:00 - 11:45 ROOM A (KONGRESS SAAL)

Chairs: Bente Finsen, Detlef Schuppan

10:00 INNATE IMMUNITY AND CNS INFLAMMATION Samia J. Khoury

10:23 SITES OF BBB DAMAGE Ingo Bechmann

10:45 ANTIGEN ENCASULATED BIODEGRADABLE PLG NANOPARTICLES FOR TOLEROGENIC TREATMENT OF AUTOIMMUNE DISEASE - MECHANISMS AND CLINICAL PROSPECTS Stephen Miller

11:08 THE MYELOID SIDE OF THE BRAIN Marco Prinz

11:30 142 - DECIPHERING THE ROLE OF ENDOGENOUS NEURAL STEM/PROGENITOR CELLS IN EXPERIMENTAL SPINAL CORD INJURY TO IDENTIFY NEW THERAPEUTIC TARGETS Antonio Tomasso (1) - Melania Cusimano (2) - Elena Brambilla (2) - Gianvito Martino (2) Vita-salute San Raffaele University, San Raffaele Scientific Institute, Milan, Italy (1) - Neuroimmunology Unit, Division Of Neuroscience, Institute Of Experimental Neurology (inspe), San Raffaele Scientific Institute, Milan, Italy (2)

T CELLS IN NEUROIMMUNE DISEASES 10:00 - 11:45 ROOM B (GUTENBERGSAAL 1)

Chairs: Jon Laman, Frauke Zipp

10:00 POSITIVE AND NEGATIVE SIGNALS OF IL-17 IN THE INDUCTION OF CNS INFLAMMATION Ari Waisman

10:23 PLASTICITY OF TH17 CELLS IN CNS AUTOIMMUNITY Thomas Korn

DAY 4 Wednesday | November 12th 2014

61

Scientific Program

10:45 TH17 CELLS IN THE INDUCTION OF CNS AUTOIMMUNITY Vijay Kuchroo

11:08 S1P SIGNALING IN CNS AUTOIMMUNITY May Han

11:30 160 - INTRAVITAL IMAGING OF T CELL ACTIVATION IN THE CNS DURING AUTOIMMUNITY Naoto Kawakami (1) - Marija Pesic (1) - Marsilius Mues (2) - Ingo Bartholomäus (2) Nikolaos Kyratsous (1) - Hartmut Wekerle (2) Institute Of Clinical Neuroimmunology, Ludwig-maximilians University Munich, Munich, Germany (1) - Neuroimmunology, Max-planck Institute Of Neurobiology, Martinsried, Germany (2)

ALZHEIMER’S DISEASE AND MICROGLIA CELLS 10:00 - 11:45 ROOM C (GUTENBERGSAAL 2)

Chairs: Monica Carson, Dimitrios Karussis

10:00 PROBING MICROGLIA FUNCTIONS IN CONTEXT Steffen Jung

10:23 THE ROLE OF CENTRAL (MICROGLIA) AND PERIPHERA(MONOCYTES INNATE IMMUNITY IN THE PATHOGENESIS AND TREATMENT OF ALZHEIMER’S DISEASE Howard Weiner

10:45 INNATE IMMUNE ACTIVATION IN ALZHEIMER’S DISEASE Michael Heneka

11:08 MICROGLIA ACTIONS IN ALZHEIMER’S DISEASE Frank Heppner

11:30 189 - AGING-INDUCED IMMUNOLOGICAL SIGNATURE OF THE BRAIN’S CHOROID PLEXUS NEGATIVELY REGULATES NEUROGENESIS AND COGNITIVE FUNCTION Aleksandra Deczkowska (1) - Kuti Baruch (1) - Eyal David (2) - Joseph M. Castellano (3) Omer Miller (1) - Alexander Kertser (1) - Tamara Berkutzki (1) - Zohar Itzhaki (2) - Dana Bezalel (2) Tony Wyss-coray (3) - Ido Amit (2) - Michal Schwartz (1) Department Of Neurobiology, Weizmann Institute Of Science, Rehovot, Israel (1) - Department Of Immunology, Weizmann Institute Of Science, Rehovot, Israel (2) - Department Of Neurology And Neurological Sciences, Stanford University School Of Medicine, Stanford, United States (3)

LUNCH BREAK 12:00 - 13:00 POSTERHALL (RHEINFOYER)

THE IMMUNOLOGY LECTURE 13:00 - 13:45 PLENARY ROOM (KONGRESS SAAL)

Chair: Ari Waisman

13:00 CYTOKINES: HOW NEUROIMMUNOLOGY TRANSFORMED INFLAMMATION RESEARCH Burkhard Becher



HERTIE SPONSORED: AUTOIMMUNITY IN THE CNS 13:45 - 15:15 ROOM A (KONGRESS SAAL)

Chair: Orhan Aktas

13:45 INTRODUCTION Eva Koch

13:50 MICROGLIA ARE UNIQUE TISSUE PHAGOCYTES WITH HIGH SELF-RENEWING CAPACITY Julia Bruttger

14:07 IMMUNE-MEDIATED NEURODEGENERATION IN EAE AND MS Volker Siffrin

14:24 CORTICAL INVOLVEMENT IN MULTIPLE SCLEROSIS: AN INSIGHT INTO NEURONAL PATHOLOGY Doron Merkler

14:41 MECHANISMS OF EARLY NEURODEGENERATION IN AUTOIMMUN OPTIC NEURITIS Ricarda Diem

14:58 IMPACT OF GLUTAREDOXIN TREATMENT ON MYELIN-DAMAGES UPON NEUROINFLAMMATION Carsten Berndt

T CELLS AND DISEASE MODELS 13:45 - 15:15 ROOM B (GUTENBERGSAAL 1)

Chair: Ariel Miller

13:45 235 - A NEW ANIMAL MODEL OF SPONTANEOUS AUTOIMMUNE PERIPHERAL POLYNEUROPATHY: IMPLICATIONS FOR GUILLAIN BARRÉ SYNDROME Mu Yang (1) - Anthony Ranoine (2) - Xiang Qun Shi (1) - Sylvie Fournier (2) - Ji Zhang (3) Department Of Neurology And Neurosurgery And Alan Edwards Centre For Research On Pain, Mcgill University, Montreal, Canada (1) - Department Of Microbiology And Immunology, Mcgill University, Montreal, Canada (2) - Department Of Neurology And Neurosurgery, Alan Edwards Centre For Research On Pain And Faculty Of Dentistry, Mcgill University, Montreal, Canada (3)

14:00 394 - INTERFERON-GAMMA-PRODUCING NATURAL KILLER CELLS ARE PATHOGENIC IN EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS BY PROMOTING M1 MACROPHAGE ACTIVATION AND VLA-4 EXPRESSION ON CD4+ T CELLS Niamh Mc Guinness (1) - Lara S. Dungan (2) - Marina. A. Lynch (1) - Kingston H.g. Mills (2) Trinity College Institute Of Neuroscience, University Of Dublin, Trinity College Dublin, Dublin, Ireland (1) Immune Regulation Research Group, School Of Biochemistry And Immunology, Trinity Biomedical Sciences Institute, University Of Dublin, Trinity College, Dublin, Ireland (2)

14:15 559 - CASEIN KINASE 2 GOVERNS THE MOLECULAR DECISION BETWEEN TH17 CELL AND TREG CELL DEVELOPMENT AND CONTROLS ENCEPHALITOGENICITY OF TH17 CELLS IN EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS Esther Witsch (1) - Alexander Ulges (2) - Katharina Birkner (1) - Gautam Pramanik (1) - Frauke Zipp 1) Tobias Bopp (2) Department Of Neurology, University Medical Center Of The Johannes Gutenberg-university, Mainz, Germany (1) Research Center Immunotherapy, University Medical Center Of The Johannes Gutenberg-university, Mainz, Germany (2)

14:30 363 - IL-1 RECEPTOR TYPE I AND TYPE II DIFFERENTIALLY REGULATE EAE PATHOGENESIS Ilgiz Mufazalov - Carsten Schelmbauer - Janina Kuschmann - Tommy Regen Christopher Hackenbruch - Ari Waisman Institue For Molecular Medicine, Jgu Medical Center, Mainz, Germany

63

Scientific Program

14:45 523 - ABNORMAL RESPONSES OF CD8+CD161HIGH MUCOSAL ASSOCIATED INVARIANT T (MAIT) CELLS AND CCR2+CCR5+ CD4 T CELLS CONTRIBUTE TO DISRUPTED BALANCE OF EFFECTOR AND REGULATORY T CELLS IN PEDIATRIC-ONSET MS Mukanthu Nyirenda (1) - Rui Li (1) - Craig Moore (1) - Ayal Rozenberg (1) - Ayman Rezk (1) - Trina Johnson (2) Dessa Sadovnick (3) - Douglas Arnold (1) - Ruth Ann Marrie (4) - Brenda Banwell (5) - Amit Bar-or (1) Neuroimmunology Unit, Montreal Neurological Institute, Mcgill University, Montreal, Canada (1) - Experimental Therapeutics Program, Montreal Neurological Institute, Mcgill University, Montreal, Canada (2) - Division Of Neurology, Department Of Medical Genetics, University Of British Columbia, British Columbia, Canada (3) - Departments Of Internal Medicine And Community Health, University Of Manitoba, Manitoba, Canada (4) Division Of Neurology, Children’s Hospital Of Philadelphia, Philadelphia, United States (5) 15:00 328 - TIM-1 IS A NOVEL TRAFFICKING RECEPTOR CONTROLLING T CELL RECRUITMENT IN THE CNS AND INDUCTION OF EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS Stefano Angiari (1) - Tiziano Donnarumma (1) - Barbara Rossi (1) - Silvia Dusi (1) - Enrica Pietronigro (1) Elena Zenaro (1) - Vittorina Della Bianca (1) - Gennj Piacentino (1) - Paul Rennert (2) - Sheng Xiao (3) Jose M. Casasnovas (4) - Vijay K. Kuchroo (3) - Gabriela Constantin (1) Department Of Pathology And Diagnostics, University Of Verona, Verona, Italy (1) - Department Of Molecular Discovery And Immunobiology, Biogen Idec Inc., Cambridge, Ma, United States (2) - Center For Neurological Diseases, Brigham And Women’s Hospital, Harvard Medical School, Boston, Ma, United States (3) Centro Nacional De Biotecnologia, Cnb-csic, Campus Uam, Madrid, Spain (4)

B CELLS AND INFECTIONS 13:45 - 15:15 ROOM C (GUTENBERGSAAL 2)

Chair: Manuel Comabella

13:45 296 - “CYTOKINE DEFINED” B CELL SUBSETS IN MULTIPLE SCLEROSIS Rui Li (1) - Simon Fillatreau (2) - Jennifer Gommerman (3) - Alexandre Prat (4) - Amit Bar-or (1) Montreal Neurological Institute, Mcgill University, Montreal, Canada (1) - Deutsches Rheuma-forschungszentrum, Leibniz Institute, Berlin, Germany (2) - Dept. Of Immunology, University Of Toronto, Toronto, Canada (3) Chum Research Centre, Notre-dame Hospital/montreal University, Montreal, Canada (4)

14:00 392 - COMPARISON OF PERIPHERAL AND CNS B CELL POPULATIONS IN NMO AND ITS IMPLICATIONS FOR B CELL TRAFFICKING USING NEXT GENERATION SEQUENCING Markus Kowarik (1) - Joe Brown (2) - Scott Wemlinger (3) - Hannah Schumann (3) - Alanna Ritchie (3) Ken Jones (2) - Greg Owens (3) - Jeffrey Bennett (4) Klinikum Rechts Der Isar, Neurologische Klinik, Tu-münchen, München, Germany (1) - Department Of Bioinformatics, University Of Colorado, Denver, United States (2) - Department Of Neurology, University Of Colorado, Denver, United States (3) - Department Of Neurology And Ophthalmology, University Of Colorado, Denver, United States (4)

14:15 438 - CB2 MODULATES SUSCEPTIBILITY TO EXPERIMENTAL CEREBRAL MALARIA THROUGH A CCL17-DEPENDENT MECHANISM Hannah Ahrends (1) - Sabine Specht (2) - Beatrix Schumak (2) - Kim Schmidt (2) - Ramona Lundt (1) - Andrea Kemter (1) - David M. Otte (1) - Stefanie Scheu (3) - Irmgard Förster (4) - Achim Hoerauf (2) - Önder Albayram (1) - Andreas Zimmer (1) - Judith Alferink (1) Institute Of Molecular Psychiatry, University Of Bonn, Bonn, Germany (1) - Institute Of Medical Microbiology, Immunology And Parasitology, University Hospital Bonn, Bonn, Germany (2) - Institute Of Medical Microbiology And Hospital Hygiene, University Of Düsseldorf, Düsseldorf, Germany (3) - Department Of Immunology And Environment, Life & Medical Sciences Institute (limes), Bonn, Germany (4)

14:30 225 - BRAIN-INFILTRATING JC VIRUS-SPECIFIC CD8+ EFFECTOR T CELLS COUNTERACT CD4+ T CELL IMMUNE ESCAPE OF NEUROTROPIC JC VIRUS VARIANT Ivan Jelcic (1) - Ilijas Jelcic (1) - Christian Kempf (2) - Fabienne Largey (1) - Raquel Planas (1) Sven Schippling (1) - Mireia Sospedra (1) - Roland Martin (1) Neuroimmunology And Multiple Sclerosis Research Section, Department Of Neurology, University Hospital Zurich, Zurich, Switzerland (1) - Institute Of Neuropathology, University Hospital Zurich, Zurich, Switzerland (2)



14:45 65 - THE CNS BARRIERS DIFFERENTIALLY REGULATE THE MIGRATION OF B CELLS Laure Michel (1) - Jorge Ivan Alvarez (1) - Hania Kebir (1) - Lyne Bourbonnière (1) - Josée Poirier (2) Pierre Duquette (2) - Amit Bar-or (3) - Jennifer Gommerman (4) - Alexandre Prat (1) Centre De Recherche Du Chum, University Of Montréal, Montréal, Canada (1) - Department Of Neurology, Chum, Montréal, Canada (2) - Department Of Neurology And Neurosurgery, Mcgill University, Montréal, Canada (3) Department Of Immunology, University Of Toronto, Toronto, Canada (4)

15:00 251 - MOLECULAR MECHANISMS GOVERNING COMPLEMENT ACTIVATION IN NEUROMYELITIS OPTICA John Soltys (1) - Scott Wemlinger (2) - Alanna Ritchie (2) - Hannah Schumann (2) - Gregory Owens (2) Jeffrey Bennett (3) University Of Colorado, University Of Colorado School Of Medicine Neuroscience And Medical Scientist Training Programs, Aurora, Co, United States (1) - University Of Colorado, University Of Colorado School Of Medicine Department Of Neurology, Aurora, Co, United States (2) - University Of Colorado, University Of Colorado School Of Medicine Department Of Neurology And Ophthalmology, Aurora, Co, United States (3)

COFFEE BREAK & POSTER SESSION | BRAIN TUMOURS AND PARANEOPLASTIC 15:15 - 16:45 POSTERHALL (RHEINFOYER)

620 - DEFINING AN IMMUNE SIGNATURE PREDICTIVE OF GLIOMA PROGRESSIONElena Bazzoli (1) - Francesca Calabria (2) - Giovanni Ciriello (3) - Ermanna Turano (2) - Alessia Farinazzo (2) Elisabetta Maffioletti (4) - Nadia Cattane (4) - Massimo Gennarelli (4) - Claudio Ghimenton (5) - Bruno Bonetti (6)

Irccs Fatebenefratelli Centro San Giovanni Di Dio, Brescia - University Of Verona, Dept Of Neurological And Movement Sciences, Verona (1) - University Of Verona - Dept Of Neurological And Movement Sciences, Verona, Verona, Italy (2) - Memorial Sloan-kettering Cancer Center, Mskcc, New York, United States (3) - Irccs Fatebenefratelli Centro San Giovanni Di Dio, Irccs Fatebenefratelli Centro San Giovanni Di Dio, Brescia, Italy (4) - University Of Verona, Verona, Verona, Italy (5) - University Of Verona, Dept Of Neurological And Movement Sciences, Verona, Verona, Italy (6)

256 - IN SITU PROXIMITY LIGATION ASSAY TO EVALUATE PRESENTATION OF A MUTATED CD4 EPITOPE IN HUMAN GLIOMA TISSUELukas Bunse (1) - Theresa Schumacher (1) - Felix Sahm (2) - Stefan Pusch (2) - Iris Oezen (1) - Andreas Von Deimling (2) Wolfgang Wick (3) - Michael Platten (3)


476 - RI ANTIBODY SYNDROME ASSOCIATED WITH AN UNUSUAL NEUROENDOCRINE TUMORGeorgios Dervenoulas2nd Department Of Neurology, Attikon University Hospital, University Of Athens, Athens, Greece

467 - ANTI-YO ANTIBODY, ASSOCIATED WITH PARANEOPLASTIC CEREBELLAR DEGENERATION, SPECIFICALLY PRODUCES PURKINJE CELL DEATH BY BINDING to the 62 kDa intracellular Yo antigen.John E. GreenleeGeorge E. Wahlen Veterans Affairs Health Care System, University Of Utah Health Sciences Center, Salt Lake City, United States

93 - IDENTIFICATION OF SEPTIN COMPLEX AS AN AUTOANTIBODY TARGET IN PARANEOPLASTIC CEREBELLAR ATAXIARamona Bahtz - Inga-madeleine Blöcker - Nora Begemann - Yvonne Denno - Stephan Tiede - Bianca Teegen - Winfried Stöcker - Christian Probst - Lars KomorowskiInstitute Of Experimental Immunology, Euroimmun Ag, Lübeck, Germany

540 - A CASE OF AN INFILTRATIVE ASTROCYTOMA IN A SIUCIDAL WOMANVasilena Petrova Deparment Of Nerve Diseases, Military Medical Academy, Sofia, Bulgaria

65

Scientific Program

185 - GUILLAIN BARRE SYNDROME AND LAMBERT EATON MYASTHENIC SYNDROME COEXISTING AS A NEW PARANEOPLASTIC NEUROLOGIC SYNDROME?Milena Rodriguez Alvarez (1) - Mark Younan (1) - Irfanali Kugasia (2) - Vipul L. Shah (1) - David Sternman (1)

Lincoln Medical Center, Affiliated To Weill Cornell Medical College, Ny, United States (1) - Lincoln Medical Center, Affiliated To Weill Cornell Medical College, Ny, United States (2)

590 - PARANEOPLASTIC CEREBELLAR DEGENERATION: AUTO-ANTIBODIES CAUSE DAMAGE TO PURKINJE CELLS BY CHANGING THE CALCIUM HOMEOSTASISManja Schubert (1) - Tilo Eichler (2) - Mette Haugen (3) - Christian Vedeler (1)

Department Of Neurology / Department Of Clinical Medicine (k1), Haukeland University Hospital / University Of Bergen, Bergen, Norway (1) - Department Of Clinical Medicine (k1), University Of Bergen, Bergen, Norway (2) - Department Of Neurology, Haukeland University Hospital, Bergen, Norway (3)

501 - MUTANT IDH1R132H BEARS A MUTATION-SPECIFIC CD4 T CELL EPITOPE SUITABLE FOR VACCINATION OF HUMAN CNS TUMORSTheresa Schumacher (1) - Lukas Bunse (1) - Stefan Pusch (2) - Felix Sahm (2) - Andreas Von Deimling (2) Wolfgang Wick (3) - Michael Platten (3)


56 - CLINICAL MANIFESTATIONS OF ANTI-NMDAR ENCEPHALITIS: CASE SERIES AND PRACTICAL RECOMMENDATIONS FOR TREATMENTSaeed Shahbeigi (1) - Amir Ali Sepehry (2) - Joel Oger (3)

Neuroimmunology Fellow From Ubc, Ubc, Vancouver, Canada (1) - 2. University Of British Columbia (ubc), College For Interdisciplinary Studies, Graduate Program In Neuroscience; Vancouver, Canada, Ubc, Vancouver, Canada (2) - Ubc Division Of Neurology, Department Of Medicine, Vancouver, Canada, Ubc, Vancouver, Canada (3)

594 - ROLE OF NANOVESCICLES FROM MACROPHAGES/MICROGLIA IN THE CROSS-TALK BETWEEN GLIOMA CELLS AND MICROENVIRONMENT.Ermanna Turano - Alessia Farinazzo - Edoardo Bistaffa - Bruno Bonetti - Elena Bazzoli Dept. Of Neurological And Movement Sciences, University Of Verona, Verona, Italy

COFFEE BREAK & POSTER SESSION | INFECTIONS 15:15 - 16:45 POSTERHALL (RHEINFOYER)

163 - HUMAN HERPES VIRUS 6 IN HUMAN EPILEPSY: DATA FROM SURGICAL RESECTIONSBridgette Jeanne Billioux (1) - Emily Leibovitch (1) - Giovanna Brunetto (1) - Irene Dustin (2) - Sara Inati (3) John Schreiber (2) - Chigo Eze (2) - Kareem Zaghloul (4) - Steve Jacobson (1) - William Theodore (2)

Neuroimmunology Branch, National Institute Of Neurological Disorders And Stroke, National Institutes Of Health, Bethesda, United States (1) - Clinical Epilepsy Section, National Institute Of Neurological Disorders And Stroke, National Institutes Of Health, Bethesda, United States (2) - Eeg Laboratory, National Institute Of Neurological Disorders And Stroke, National Institutes Of Health, Bethesda, United States (3) - Surgical Neurology Branch, National Institute Of Neurological Disorders And Stroke, National Institutes Of Health, Bethesda, United States (4)

478 - LY6CHI MONOCYTES GOVERN CEREBRAL TOXOPLASMOSISAindrila Biswas - Ildiko Rita DunayInstitute Of Medical Microbiology, Otto-von-guericke University, Magdeburg, Germany

361 - PERIPHERAL SYMPATHECTOMY AFFECTS THE COURSE AND SEVERITY OF FRIEND RETROVIRUS INFECTION IN MICEDominique Bloemker (1) - Kathrin Gibbert (2) - Adriana Del Rey (3) - Ulf Dittmer (2) - Manfred Schedlowski (1) - Harald Engler (1)

Institute Of Medical Psychology And Behavioral Immunobiology, University Hospital Essen, Essen, Germany (1) - Institute Of Virology, University Hospital Essen, Essen, Germany (2) - Department Of Immunophysiology, Institute Of Physiology And Pathophysiology, Phillipps University Of Marburg, Marburg, Germany (3)



422 - DROPLET DIGITAL PCR FOR THE PRECISE QUANTIFICATION OF HTLV-1Breanna Caruso - Giovanna Brunetto - Raya Massoud - Emily Leibovitch - Steven Jacobson Ninds, Nih, Bethesda, United States

582 - RISK FACTORS FOR IMMUNOSUPPRESSION-ASSOCIATED INFECTIONS IN AQUAPORIN-4 ANTIBODY MEDIATED NEUROMYELITIS OPTICA SPECTRUM DISORDERSFan Cheng (1) - Jithin George (1) - J Rocha (2) - George Tackley (1) - John Revis (1) - Paddy Waters (1) - John Elston (3) Jacqueline Palace (1) - Nicola Jones (4) - Maria Isabel Leite (1)

Nuffield Department Of Clinical Neurosciences, University Of Oxford, Uk, John Radcliffe Hospital, University Of Oxford, Oxford, United Kingdom (1) - Department Of Clinical Neurology, Hospital S. Marcos, Braga, Portugal, Braga, Portugal (2) - The Oxford Eye Hospital, John Radcliffe Hospital, University Of Oxford, Uk, Oxford, United Kingdom (3) - Department Of Infectious Diseases, John Radcliffe Hospital, University Of Oxford, Uk, Oxford, United Kingdom (4)

245 - PLASMA HEME LEVELS CORRELATE WITH IP-10 LEVELS DURING FATAL CEREBRAL MALARIA IN ODISHA, INDIAEsther DalkoCiil, Cnrs Umr 8204, Inserm U1019, Institut Pasteur De Lille, Pres Université Lille Nord De France, Lille, France

337 - VIRUS INFECTION VIA THE OLFACTORY ROUTE TRIGGERS PRIMARILY ASTROCYTES WITHIN THE OLFACTORY BULB TO EXPRESS IFN-BETA WHICH TRIGGERS IFNAR THROUGHOUT THE BRAINClaudia N. Detje (1) - Stefan Lienenklaus (2) - Julia Heinrich (1) - Claudia Soldner (1) - Michael G. Tovey (3) - Siegfried Weiss (2) - Ulrich Kalinke (1)

Institute For Experimental Infection Research, Twincore, Centre For Experimental And Clinical Infection Research, Hannover, Germany (1)

Molecular Immunology, Helmholtz Centre For Infection Research, Braunschweig, Germany (2) - Laboratory Of Viral Oncology, Cnrs, Villejuif, France (3)

418 - REGULATORY T CELLS IN CNS TOXOPLASMA GONDII INFECTIONTajie HarrisUniversity Of Virginia, University, Charlottesville, United States

613 - NEURONS ARE HOST CELLS FOR MYCOBACTERIUM TUBERCULOSISPhilippa J Randall (1) - Nai-jen Hsu (1) - Dirk Lang (2) - Susan Cooper (2) - Boipelo Sebesho (1) - Nasiema Allie (1) Roanne Keeton (1) - Ngiambudulu Francisco (1) - Sumayah Salie (1) - Antoinette Labuschagne (1) - Valerie Quesniaux (3) Bernhard Ryffel (3) - Lauriston Kellaway (2) - Muazzam Jacobs (1)

Division Of Immunology, Department Of Clinical Laboratory Scienecs And The Iidmm, Faculty Of Health Sciences, University Of Cape Town, Cape Town, South Africa (1) - Department Of Human Biology, Faculty Of Health Sciences, University Of Cape Town, Cape Town, South Africa (2) - Experimental And Molecular Immunology And Neurogenetics, University Of Orleans And Cnrs Umr7355, Orleans, France (3)

463 - VIRAL LOAD AND T-HELPER-1-CELL CYTOKINES IN MYALGIC ENCEPHALOMYELITISIrina Malashenkova (1) - Sergey Krynskiy (2) - Daniil Ogurtsov (2) - Nikita Hailov (1) - Galina Kazanova (1) - Olga Gurskaya (2) Maria Jarova (2) - Igor Zuikov (2) - Elvira Domonova (3) - O.yu Silveystrova (3) - Nikolay Didkovskiy (2)

Laboratory Of Immunology, National Research Center Kurchatov Institute, Moscow, Russian Federation (1) - Laboratory Of Clinical Immunology, Science Research Institution Of Pchysical-chemical Medicine, Moscow, Russian Federation (2) - Department Of Molecular Diagnostics, Central Research Institute For Epidemiology, Of Rospotrebnadzor Moscow, Russian Federation (3)

429 - CHARACTERIZATION OF EPSTEIN-BARR VIRUS GENOTYPES IN MULTIPLE SCLEROSIS THROUGH NEXT GENERATION SEQUENCING APPROACHESGiulia Coarelli (1) - Caterina Manzari (2) - Anita Annese (2) - Eleni Anastasiadou (3) - Claudia Policano (1) - Anna Maria D’erchia (2) - Ernesto Picardi (2) - Maria Chiara Buscarinu (1) - Viviana Annibali (1) - Vito Ag Ricigliano (1) - Antonia Tullo (4) - Pankaj Trivedi (3) - Graziano Pesole (5) - Giovanni Ristori (1) - Marco Salvetti (1) - Rosella Mechelli (1)

Centre For Experimental Neurological Therapies (centers), Department Of Neurosciences, Mental Health And Sensory Organs, Faculty Of Medicine And Psychology, Sapienza University Of Rome, Italy (1) - Department Of Biosciences, Biotechnology And Biopharmaceutical, Bari University, Bari, Italy (2) - Department Of Experimental Medicine, Sapienza University Of Rome, Rome, Italy (3)

Institute For Biomedical Technologies, National Research Council, Bari, Italy (4) - Department Of Biosciences, Biotechnology And Biopharmaceutical, Bari University, Bari, Italy Institute Of Biomembranes And Bioenergetics, National Research Council, Bari, Italy (5)

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Scientific Program

506 - CMV INFECTION FACILITATES EAE DEVELOPMENT IN RESISTANT BALB/C MICEJelena Milovanovic (1) - Marija Milovanovic (1) - Aleksandar Arsenijevic (1) - Bojana Stojanovic (1) - Branka Popovic (2)

Nebojsa Arsenijevic (1) - Stipan Jonjic (2) - Miodrag L. Lukic (1)

Center For Molecular Medicine And Stem Cell Research, Faculty Of Medicine University Of Kragujevac, Kragujevac, Serbia (1) Department For Histology And Embryology, Center For Proteomics, School Of Medicine, University Of Rijeka, Rijeka, Croatia (2)

401 - PATHOLOGICAL FEATURES OF INFLAMMATORY PML IN NON-HIV PATIENTS, COMPARED TO CLASSICAL PML-IRIS IN HIV PATIENTSHelena Radbruch (1) - Hélène Gros (2) - Klara Kaden (1) - Klemens Ruprecht (3) - Werner Stenzel (1)

Institut Für Neuropathologie, Charité, Berlin, Germany (1) - Infectious Diseases, Robert Ballanger General Hospital, Aulnay Sous Bois, France (2) - Klinik Für Neurologie, Charité, Berlin, Germany (3)

283 - IMMUNE CELL RECRUITMENT TO THE BRAIN DURING CNS TBAnna Ritter School Of Medicine And Public Health, University Of Wisconsin-madison, Madison, United States

623 - INDUCTION AND RECRUITMENT OF MYELIN-SPECIFIC CD4 T CELLS DURING PERSISTENT JHMV INFECTIONCarine Savarin - Cornelia Bergmann - Stephen Stohlman Lerner Research Institute, Cleveland Clinic, Cleveland, United States

622 - IMMUNO-REGULATORY ROLE OF TNF IN CENTRAL NERVOUS SYSTEM TUBERCULOSISBoipelo Sebesho - Lauriston Kellaway - Muazzam Jacobs University Of Cape Town, University, Cape Town, South Africa

290 - EBV NUCLEAR ANTIGEN-1 EPITOPE REACTIVE TO INTRATHECAL ANTIBODIES IN THE CEREBROSPINAL FLUID OF PATIENTS WITH MULTIPLE SCLEROSISHayden Collins (1) - Dicle Gunaydin (1) - Kayo Tamanito (1) - Nadeen Ibrahim (1) - Antonina Dolei (2) - Xiaoli Yu (1)

University Of Colorado Anschutz Medical Campus, Neurology, University Of Colorado Anschutz Medical Campus, Aurora, United States (1) - University Of Sassari, Department Of Biomedical Sciences And Centre Of Excellence For Biotechnology Development And Biodiversity Research, University Of Sassari, Sassari, Italy (2)

COFFEE BREAK & POSTER SESSION | MECHANISMS OF CNS DISEASE 15:15 - 16:45 POSTERHALL (RHEINFOYER)

42 - ASTROCYTE DEFORMATION AND NEUROVASCULAR DISRUPTION - PATHOLOGICAL MECHANISM THAT MEDIATE NEURONAL INJURY AND CORTICAL DAMAGE IN EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITISRina Aharoni - Raya Eilam - Michael Sela - Ruth Arnon The Weizmann Institute Of Science, Universitiy, Rehovot, Israel

413 - CLIPPERS SYNDROME:CASE REPORTAyse Altintas - Bengi Gul Alpaslan - Ugur UygunogluCerrahpasa Medical School, Istanbul University, Istanbul, Turkey

421 - MYD88 SIGNALING MEDIATES THE EFFECTS OF THE INNATE IMMUNE RESPONSE IN CEREBELLAR SHORT-TERM SYNAPTIC PLASTICITYAlonso Barrantes-freer (1) - Lena Sünke Mortensen (2) - Melanie Lohrberg (3) - Alexander Götz (1) Uwe-karsten Hanisch (1) - Luis A. Pardo (4) - Wolfgang Brück (1) - Christine Stadelmann-nessler (1)

Institut Of Neuropathology, University Medical Center Göttingen (umg), Göttingen, Germany (1) - Abt. Molekulare Neurobiologie, Max Planck Institut Für Experimentelle Medizin, Göttingen, Germany (2) - Masters Programm Molekulare Medizin, University Medical Center Göttingen (umg), Göttingen, Germany (3) - Abt. Onkophysiologie, Max-planck Institut Für Experimentelle Medizin, Göttingen, Germany (4)

258 - IMPACT OF DIETARY METABOLISM BY GUT MICROBIOTA ON THE PATHOGENESIS OF SPONTANEOUS AUTOIMMUNE ENCEPHALOMYELITISKerstin Berer (1) - Inés Martínez (2) - Alesia Walker (3) - Philippe Schmitt-kopplin (3) - Jens Walter (2) Hartmut Wekerle (1) - Gurumoorthy Krishnamoorthy (1)

Department Of Neuroimmunology, Max Planck Institute Of Neurobiology, Munich, Germany (1) - Department Of Agricultural, Food And Nutritional Science, University Of Alberta, Edmonton, Canada (2) - Research Unit Analytical Biogeochemistry, Helmholtz Zentrum München, Munich, Germany (3)



80 - NEUROPATHIC PAIN-INDUCED DEPRESSIVE-LIKE BEHAVIOR IS ASSOCIATED WITH MYELIN REMODELING AND IMPAIRED NEUROGENESISAnna Dellarole (1) - Paul Morton (1) - Roberta Brambilla (1) - Winston Walters (1) - Spencer Summer (1) Danielle Bernardes (2) - Mariagrazia Grilli (3) - John Bethea (2)

The Miami Project To Cure Paralysis, University Of Miami, Miami, - (1) - Biology Department, Drexel University, Philadelphia, United States (2) - Department Of Pharmaceutical Sciences, University Of Piemonte Orientale, Novara, Italy (3)

91 - THALAMO-CORTICAL NETWORKING DURING DE- AND REMYELINATION EVENTS IN THE CUPRIZONE MODEL OF MULTIPLE SCLEROSIS: A VOLTAGE-SENSITIVE DYE STORYManuela Cerina (1) - Venu Narayanan (1) - Kerstin Göbel (1) - Patrick Meuth (1) - Erwin J. Speckmann (2) - Ali Gorji (2) Nikoo Ghaffarian (1) - Thomas Budde (2) - Sven G. Meuth (1)

Clinic Of Neurology - Neurophysiology, University Hospital Münster, Münster, Germany (1) - Institute Of Physiology I, Münster University, Münster, Germany (2)

233 - THE WAKEFULNESS PROMOTING AGENT MODAFINIL AMELIORATES EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITISLynn Bedford (1) - James Crooks (1) - Manjit Kaur Braitch (2) - Ranjithmenon Muraleedharan (1) - Bruno Gran (3) Cris Constantinescu (3)

University Of Nottingham, University Of Nottingham, Nottingham, United Kingdom (1) - University Of Birmingham, University Of Nottingham, Birmingham, United Kingdom (2) - University Of Nottingham, Queen’s Medical Centre, University Of Nottingham, Nottingham, United Kingdom (3)

227 - AGE-RELATED CHANGES IN INTESTINAL PERMEABILITY AND GUT MICROBIOTA AFTER ISCHEMIC STROKEJoshua Crapser - Rodney Ritzel - Sarah Doran - Edward Koellhoffer - Anita Patel - Brett Friedler Mcculloug Louise University Of Connecticut Health Center, University Of Connecticut Health Center, Farmington, United States

179 - PATHOLOGICAL MECHANISMS IN PATIENTS WITH ANTIBODIES TO GLYCINE RECEPTORS Sarah Crisp (1) - John Rothwell (1) - Angela Vincent (2) - Dimitri M. Kullmann (1)

Institute Of Neurology, University College London, London, United Kingdom (1) - Nuffield Department Of Clinical Neurosciences, John Radcliffe Hospital, Oxford, United Kingdom (2)

370 - DETECTION OF ANTIBODIES AGAINST THE N-METHYL-D-ASPARTATE RECEPTOR IN A SUB-GROUP OF PATIENTS DIAGNOSED WITH TOURETTE’S SYNDROMEPriyamvada Dua (1) - Leslie Jacobson (2) - Andrew Church (3) - Davide Martino (1) - Sofia Sisay (1) - Angela Vincent (2) Bethan Lang (2) - Gavin Giovannoni (1) - Ute Meier (1)

Centre For Neuroscience And Trauma, Queen Mary University Of London, London, United Kingdom (1) - Division Of Clinical Neurology, University Of Oxford, Oxford, United Kingdom (2) - Insititute Of Neurology, University College London, London, United Kingdom (3)

287 - ACUTE SEIZURES DURING VIRAL ENCEPHALITIS ARE DUE TO IL-6-PRODUCING MACROPHAGESMatthew Cusick (1) - Jane Libbey (1) - Dipan Patel (2) - Karen Wilcox (2) - Robert Fujinami (1)

University Of Utah, Department Of Pathology, Salt Lake City, United States (1) - University Of Utah, Department Of Pharmacology And Toxicology, Salt Lake City, United States (2)

135 - TRPM2 CATION CHANNEL REGULATES DETRIMENTAL IMMUNE CELL INVASION IN ISCHEMIC STROKEMathias Gelderblom (1) - Nico Melzer (2) - Benjamin Schattling (3) - Eva Göb (4) - Gordon Hicking (2) - Priyadharshini Arunachalam (1) - Stefan Bittner (2) - Friederike Ufer (5) - Alexander M. Herrmann (2) - Christian Bernreuther (6) Markus Glatzel (6) - Christian Gerloff (1) - Christoph Kleinschnitz (4) - Sven G. Meuth (2) - Manuel A. Friese (5) Tim Magnus (1)

Department Of Neurology, University Medical Center Hamburg-eppendorf, Hamburg, Germany (1) - Department Of Neurology, University Of Muenster, Muenster, Germany (2) - Center For Molecular Neurobiology, University Medical Center Hamburg-eppendorf, Hamburg, - (3) - Department Of Neurology, University Hospital Wuerzburg, Wuerzburg, Germany (4) - Center For Molecular Neurobiology, University Medical Center Hamburg-eppendorf, Hamburg, Germany (5) - Institute Of Neuropathology, University Medical Center Hamburg-eppendorf, Hamburg, Germany (6)

561 - IN VIVO CNS CHRONIC INFUSION OF AQP4-IGG INDUCES NMO-LIKE LESIONS AND MOTOR BEHAVIORAL CHANGES IN RAT VIA ASTROCYTOPATHY AND GLUTAMATE HOMEOSTASIS DISTURBANCEPascale GiraudonLyon Neuroscience Research Center, University Of Lyon, Lyon, France

69

Scientific Program

276 - CHARACTERIZING THE ROLE OF INTEGRIN ALPHA8 IN MEDIATING CD4+ T LYMPHOCYTE MIGRATION ACROSS THE BLOOD BRAIN BARRIER IN MULTIPLE SCLEROSISElizabeth Gowing (1) - Steve Gendron (1) - Marc-andré Lécuyer (1) - Simone Terouz (1) - Alexandre Prat (1)

Centre De Recherche Du Centre Hospitalier De L’université De Montréal (crchum), Université De Montréal, Montréal, Canada (1)

542 - IMAGING OF PATHOLOGICAL EFFECTS OF AQUAPORIN-4 SPECIFIC ANTIBODIES EX VIVO AND IN VIVOMarina Herwerth (1) - Rajneesh Srivastava (1) - Suhakar Reddy Kalluri (1) - Thomas Misgeld (2) - Bernhard Hemmer (1)

Neurologische Klinik Und Poliklinik Rechts Der Isar, Technische Universität, München, Germany (1) - Institute Of Neuronal Cell Biology, Technische Universität, München, Germany (2)

556 - ANALYSIS OF AUTO-ANTIBODIES IN SCHIZOPHRENIA Carolin Hoffmann (1) - Matthew J Lindemann (2) - Vincent C Ramsperger (2) - Lakshmanan Suresh (2) - Jo Stevens (1) Mario Losen (1) - Peter Molenaar (1) - Marc H De Baets (1) - Marc De Hert (3) - Jim Van Os (1) - Bart Bp Rutten (1) Pilar Martinez-martinez (1)

Department Of Psychiatry And Neuropsychology, Maastricht University, Maastricht, Netherlands (1) - Immco Diagnostics, Inc., New York, United States (2) - University Psychiatric Centre Catholic University Leuven, Catholic University Leuven, Leuven, Belgium (3)

543 - ANALYSIS OF PATHOGENIC AUTOANTIBODIES AGAINST THE N-METHYL-D-ASPARTATE GLUTAMATE RECEPTOR IN SCHIZOPHRENIACarolin Hoffmann (1) - Gisela Nogales-gadea (1) - Jo Stevens (1) - Mario Losen (1) - Andrei Szoke (2) - Marion Leboyer (2) Marc De Hert (3) - Nico J M Van Beveren (4) - Peter Molenaar (1) - Wim A Buurman (1) - Marc H De Baets (1) Bart B F Rutten (1) - Jim Van Os (1) - Pilar Martinez-martinez (1)

Department Of Psychiatry And Neuropsychology, Maastricht University, Maastricht, Netherlands (1) - Pôle De Psychiatrie, Hôpital Henri Mondor – Albert Chenevier – Assistance Publique – Hôpitaux De Paris, Université Paris-est Créteil, Créteil, France (2) - University Psychiatric Centre Catholic University Leuven, Catholic University Leuven, Campus Kortenberg, Leuven, Belgium (3) - Department Of Psychiatry, Erasmus University Medical Center, Rotterdam, Netherlands (4)

304 - FACTOR H AUTOANTIBODIES IN NEUROMYELITIS OPTICAZsolt Illes (1) - Barbara Uzonyi (2) - Mihaly Jozsi (2)

Institute Of Clinical Research And Department Of Neurology, University Of Southern Denmark, Odense, Denmark (1) Mta-elte Immunology Research Group, Department Of Immunology, Eötvös Loránd University, Budapest, Hungary (2)

306 - LONGITUDINAL SEROLOGICAL AND CLINICAL DATA INDICATE THAT SLE ACTIVITY MAY CONTRIBUTE TO NMO RELAPSESZsolt Illes (1) - Katalin T. Kovacs (2) - Sudhakar R. Kalluri (3) - Tunde Csepany (4) - Yvonne Schaefer (3) Magdolna Simo (5) - Laszlo Rokusz (6) - Timea Berki (7) - Bernhard Hemmer (3)

Institute Of Clinical Research And Department Of Neurology, University Of Southern Denmark, Odense, Denmark (1) - Department Of Rheumatology And Immunology, University Of Pecs, Pecs, Hungary (2) - Clinic Of Neurology, Technische Universität München, Munich, Germany (3) - Department Of Neurology, University Of Debrecen, Debrecen, Hungary (4) - Department Of Neurology, Semmelweis University, Budapest, Hungary (5) - 1st Department Of Internal Medicine, Military Hospital - State Health Centre, Budapest (6) Department Of Immunology And Biotechnology, University Of Pecs, Pecs, Hungary (7)

435 - SULFATIDES AUTOREACTIVITY IN MULTIPLE SCLEROSISMaria Ivanova (1) - Amir Tukhvatulin (2) - Alina Dzharullaeva (2) - Denis Logunov (2) - Maria Zakharova (1)

Research Center Of Neurology, Russian Academy Of Medical Sciences, Moscow, Russian Federation (1) - Gamaleya Research Institute Of Epidemiology And Microbiology, Ministry Of Health Of The Russian Federation, Moscow, Russian Federation (2)

136 - REGULATION OF EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS BY GUT RESIDENT T CELLSAtsushi Kadowaki (1) - Sachiko Miyake (2) - Asako Chiba (2) - Takashi Yamamura (1)

National Center Of Neurology And Pscychiatry, Hospital, Tokyo, Japan (1) - Juntendo University Graduate School Of Medicine, University, Tokyo, Japan (2)

172 - EXPRESSION OF EMMPRIN ON ASTROCYTES: RELEVANCE TO NORMAL AND DISEASED BRAINDeepak Kaushik - Claudia Silva - Janet Wang - Wee Yong Hotchkiss Brain Institute, University Of Calgary, Calgary, Alberta, Canada

447 - THE ROLE OF NG2 AND OPC IN INDUCTION AND DEVELOPMENT OF CNS INFLAMMATIONKhalad Karram - Maja Kitic - Nicole Israel - Florian Wanke - Florian C. Kurschus - Ari Waisman Institute For Molecular Medicine, University Medical Center Of The Johannes Gutenberg University Mainz, Mainz, Germany



388 - CLINICAL FEATURES OF SARCOID MYELOPATHY FOCUSING ON AGE, DISTRIBUTION, AND CONCOMITANT SPINAL DISEASEHiroshi Kuroda (1) - Kazuo Fujihara (2) - Yasuto Itoyama (3) - Masashi Aoki (1)

Department Of Neurology, Tohoku University Graduate School Of Medicine, Sendai, Japan (1) - Department Of Multiple Sclerosis Therapeutics, Tohoku University Graduate School Of Medicine, Sendai, Japan (2) - National Center Of Neurology And Psychiatry, National Center Hospital, Tokyo, Japan (3)

356 - FIBROBLAST GROWTH FACTOR 9 AND ITS DOWNSTREAM REGULATORS IN THE PATHOGENESIS OF MULTIPLE SCLEROSIS.Daniel Mcelroy (1) - Katja Thuemmler (1) - Maren Lindner (1) - Cornelia Schuh (2) - Hans Lassmann (2) Christopher Linington (1)

Institute Of Infection, Immunity, & Inflammation, University Of Glasgow, Glasgow, United Kingdom (1) Center For Brain Research, Medical University Of Vienna, Vienna, Austria (2)

220 - REGIONAL DIFFERENCES IN VISCOELASTICITY IN NORMAL AND INFLAMED MOUSE BRAINJason Millward (1) - Jing Guo (2) - Dominique Berndt (1) - Jürgen Braun (2) - Ingolf Sack (2) - Carmen Infante-duarte (1)

Institute For Medical Immunology, Charité - Universitätmedizin Berlin, Berlin, Germany (1) - Department Of Radiology, Charité - Universitätmedizin Berlin, Berlin, Germany (2)

527 - ACTIVATED T CELLS INDUCE OLIGODENDROCYTE PROGENITOR CELLS PROLIFERATION BY RELEASING VEGF-AElliot Choi - Tonguang Wang - Avindra Nath National Institutes Of Health, Ninds, Bethesda, United States

434 - KEY ROLE OF TREM-2 ON MICROGLIA IN CUPRIZONE-INDUCED DEMYELINATION MODELClaudia Cantoni (1) - Karel Otero (2) - Bryan Bollman (1) - Anne Cross (1) - Laura Piccio (1)

Department Of Neurology, Washington University In St Louis, St Louis, United States (1) - Biogen, Biogen, Boston, United States (2)

466 - FLUORESCENCE LIFETIME IMAGING REVEALS NADPH OXIDASE OVERACTIVATION AS A MECHANISM OF MULTIPLE SCLEROSIS PATHOGENESISHelena Radbruch (1) - Agata Mossakowski (1) - Julian Pohlan (1) - Raluca Niesner (2)

Institut Für Neuropathologie, Charité, Berlin, Germany (1) - Ag Biophysical Analytics, Drfz, Berlin, Germany (2)

302 - DUAL ACTIVITY OF INTERFERON GAMMA IN EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITISLilian Reyes (1) - Juan Tichauer (2) - Eric Acuña (2) - Claudia Cárcamo (3) - Patrizia De Sarno (4) - Chander Raman (5) Rodrigo Naves (2)

Department Of Biological And Chemistry Sciences, Universidad San Sebastián, Santiago, Chile (1) - Institute Of Biomedical Sciences, Universidad De Chile, Santiago, Chile (2) - Department Of Neurology, Pontificia Universidad Católica De Chile, Santiago, Chile (3) Department Of Psychiatry And Behavioral Neurobiology, University Of Alabama At Birmingham, Birmingham, Alabama, United States (4) Departments Of Medicine And Microbiology, University Of Alabama At Birmingham, Birmingham, Alabama, United States (5)

196 - IMMUNOLOGICAL STUDIES OF INFLAMMATORY BASAL GANGLIA DISORDERSHiroshi Sakuma (1) - Eri Nakahara (1) - Tomohiro Suzuki (1) - Kuniko Kohyama (1) - Masaharu Hayashi (1)

Department Of Brain Development And Neural Regeneration, Tokyo Metropolitan Institute Of Medical Science, Tokyo, Japan (1)

357 - NON-LYTIC AUTOANTIBODY MEDIATED EFFECTS ON MYELINATION ARE ASSOCIATED WITH INCREASED PRO-INFLAMMATORY CHEMOKINE EXPRESSIONTiia Semenoff - Katie Chapple - Christopher Linington - Katja Thuemmler Institute Of Infection, Immunity And Inflammation, University Of Glasgow, Glasgow, United Kingdom

146 - A DUAL ROLE FOR FIBROBLAST GROWTH FACTOR 9 IN MULTIPLE SCLEROSIS: INHIBITION OF (RE)MYELINATION AND INDUCTION OF PRO-INFLAMMATORY ENVIRONMENT Katja Thuemmler (1) - Daniel Mcelroy (1) - Maren Lindner (1) - Ariel Arthur (1) - Christina Elliott (1) - Anna Williams (2) - Edgar Meinl (3) - Hans Lassman (4) - Christopher Linington (1)

Institute Of Infection, Immunity And Inflammation, University Of Glasgow, Glasgow, United Kingdom (1) - Mrc Centre For Inflammation Research, University Of Edinburgh, Edinburgh, United Kingdom (2) - Institute For Clinical Neuroimmunology, Ludwig Maximillian University, Munich, Germany (3) - Brain Research Institute, Department Of Neuroimmunology, University Of Vienna, Vienna, Germany (4)

71

Scientific Program

386 - INCREASED EXPRESSION KIR 4.1 POTASSIUM CHANNEL IN EXPERIMENTAL MODELS OF DEMYELINATION.Laura Turati - Chiara Cordiglieri - Chiara Toscani - Francesca Andreetta - Pia Bernasconi - Renato Mantegazza Fulvio Baggi Neurology Iv Unit, Neurological Institute “Carlo Besta”, Milan, Italy

391 - DIFFERENTIAL TGF-BETA SIGNALING IN GLIAL SUBSETS UNDERLIES IL-6-MEDIATED EPILEPTOGENESIS IN MICEEkaterina Vinogradov (1) - Nitzan Tagel Levy (1) - Dan Milikovsky (2) - Gytis Baranuskas (2) - Yaron David (2) Maya Ketzef (2) - Shai Abutbul (1) - Itai Weissberg (2) - Ilya Fleidervish (2) - Alon Friedman (2) - Alon Monsonego (1)

The Shraga Segal Dept. Of Microbiology And Immunology, Faculty Of Health Sciences And The National Institute Of Biotechnology In The Negev, Ben-gurion University, Beer-sheva, Israel (1) - The Dept. Of Physiology And Neurobiology, Zlotowski Center For Neuroscience, Ben-gurion University, Beer-sheva, Israel (2)

87 - MOLECULAR MECHANISMS OF OXIDATIVE TISSUE INJURY DIFFER BETWEEN MULTIPLE SCLEROSIS AND EXPERIMENTAL DISEASE MODELSIsabella Wimmer - Cornelia Schuh - Simon Hametner - Jan Bauer - Monika Bradl - Hans Lassmann Center For Brain Research/ Department Of Neuroimmunology, Medical University Of Vienna, Vienna, Austria

301 - INTERFERON-BETA CONFERS PROTECTIVE EFFECTS AGAINST ISCHEMIC STROKE THROUGH ITS ANTI-INFLAMMATORY PROPERTIESPing-chang Kuo - Barbara Scofield - Jui-hung Yen Indiana University School Of Medicine, Indiana University, Fort Wayne, In, United States

546 - IL-17A PROMOTES MYELIN LOSS AND INFLAMMATORY RESPONSE DURING CUPRIZONE-INDUCED DEMYLINATIONJulian Zimmermann (1) - Michael Emrich (1) - Marius Krauthausen (1) - Simon Saxe (1) - Michael Heneka (2) Iain Campbell (3) - Marcus Müller (1)

Dept. Of Neurology, University Hospital Of Bonn, Bonn, Germany (1) - Clinical Neuroscience, University Hospital Of Bonn, Bonn, Germany (2) - School Of Molecular Bioscience, University Of Sydney, Sydney, Australia (3)

COFFEE BREAK & POSTER SESSION | NEURODEGENERATION 15:15 - 16:45 POSTERHALL (RHEINFOYER)

271 - AXONAL TRANSPORT DEFICITS DURING AUTOIMMUNE OPTIC NEURITISJovana Bojcevski - Sarah K Williams - Ricarda Diem - Richard Fairless Neuro-oncology, University Clinic Heidelberg, Heidelberg, Germany

156 - OXIDATIVE STRESS ALTERS MITOCHONDRIA AT THE NODES OF RANVIER OF EX VIVO TRANSECTED AXONSElena Bros (1) - Jason Millward (1) - Raluca Niesner (2) - Friedemann Paul (3) - Carmen Infante-duarte (1)

Institute For Medical Immunology, Charité Universitätsmedizin, Berlin, Germany (1) - Deutsches Rheuma-forschungszentrum, Drfz, Berlin, Germany (2) - Neurocure Clinical Research Center, Charité Universitätsmedizin, Berlin, Germany (3)

149 - HIGH GLUTATHIONE-S-TRANSFERASE 4 ALPHA EXPRESSION PROMOTES NERVE CELL SURVIVAL IN NEURODEGENERATIVE DISORDERSKarl Carlström - Faiez Al Nimer - Mikael Ström - Fredrik Piehl Department Of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden

457 - BENEFICIAL ROLE OF REGULATORY T CELLS IN A MOUSE MODEL OF ALZHEIMER’S DISEASECira Dansokho (1) - Dylla Ait Ahmed (1) - Cécile Toly-ndour (1) - Saba Aid (2) - Thomas Chaigneau (1) - Vanessa Calle (1) Nicolas Cagnard (3) - Martin Holzenberger (2) - Eliane Piaggio (4) - Pierre Aucouturier (1) - Guillaume Dorothée (1)

Inserm Umrs 938, Laboratory Immune System, Neuroinflammation And Neurodegenerative Diseases, Saint-antoine Hospital, Paris, France (1) - Inserm Umrs 938, Laboratory Neuroendocrine Mechanisms Of Longevity And Age-related Diseases, Saint-antoine Hospital, Paris, France (2) - Faculty Of Medicine Paris Descartes, Bioinformatics Platform, Necker Hospital, Paris, France (3) - Inserm U932, Laboratory Of Immunology, Curie Institute, Paris, France (4)



550 - MODULATION OF THE ENDOCANNABINOID SYSTEM AND PANX1-MEDIATED NEUROINFLAMMATION IN AN IN VITRO MODEL OF ALZHEIMER’S DISEASESteven Fagan (1) - Veronica A. Campbell (2)

Trinity College Institute Of Neuroscience, University Of Dublin, Trinity College, Department Of Physiology, Dublin, Ireland (1) Trinity College Institute Of Neuroscience, Department Of Physiology, University Of Dublin, Trinity College, Dublin, Ireland (2)

310 - GENE EXPRESSION ANALYSIS OF RETINAL NEURONS IN EXPERIMENTAL AUTOIMMUNE OPTIC NEURITISSabine Herold (1) - Prateek Kumar (1) - Sven Wichert (2) - Mathias Baehr (1) - Moritz Rossner (2) - Katharina Hein (1)

University Medicine Goettingen, Neurology, Goettingen, Germany (1) - Clinic For Psychiatry And Physiology, Clinic For Psychiatry And Physiology, Munich, Germany (2)

324 - A ROLE FOR THE COMPLEMENT ALTERNATIVE PATHWAY IN THE PATHOLOGY OF MULTIPLE SCLEROSIS GREY MATTER LESIONSLewis M. Watkins (1) - Samantha Loveless (2) - James Neal (3) - Mark I. Rees (1) - Neil Robertson (2) Richard Reynolds (4) - B. Paul Morgan (3) - Owain W. Howell (1)

Institute Of Life Sciences, Swansea University, Swansea, United Kingdom (1) - Institute Of Psychological Medicine And Clinical Neurosciences, Cardiff University, Cardiff, United Kingdom (2) - Institute Of Infection & Immunity, Cardiff University, Cardiff, United Kingdom (3) - Division Of Brain Sciences, Imperial College London, London, United Kingdom (4)

326 - ROLE OF PURINERGIC RECEPTORS IN ALZHEIMER’S DISEASE: INSIGHTS FROM ANIMAL MODELSElodie Martin (1) - Majid Amar (1) - Ihsen Youssef (1) - Jean Kanellopoulos (2) - Bertrand Fontaine (1) Benoit Delatour (1) - Delarasse Cecile (1)

Brain And Spine Institute (icm), Hopital Pitié-salpêtrière, Paris, France (1) - University Paris Sud, University Paris Sud, Orsay, France (2)

634 - COMPLEX NEURO-IMMUNOLOGY CHALLENGES IN RESOURCE LIMITED HEALTH SETTINGSJoshua Ngwang Menang (1) - Samuel Njimogu (2) - Edward Ngwa (1)

Calmef Health Centre, Calmef Health Centre, Tiko, Cameroon (1) - Bingo Annex Bamenda, St Louis University Of Medicine And Health Sciences, Bamenda, Cameroon (2)

169 - INHIBITION OF KYNURENINE 3-MONOOXYGENASE IN EAE Iris Oezen (1) - Iris Mildenberger (1) - Michael Platten (2)

Ccu Neuroimmunology And Brain Tumor Immunology, German Cancer Research Center, Heidelberg, Germany (1) Department Of Neurooncology, University Hospital Heidelberg, Heidelberg, Germany (2)

364 - ASTROCYTIC DYSFUNCTION INDUCED BY L-ALPHAAMINOADIPIC ACID REDUCES MEASURES OF NEURONAL COMPLEXITY IN VITRO; RESCUE BY NMDA RECEPTOR ANTAGONISTS Eileen O’toole - Marika Doucet - Andrew Harkin Trinity College Institute Of Neuroscience, Trinity College Dublin, Dublin, Ireland

161 - NEW IL-22 FUNCTION AND ITS RELEVANCE IN MSGuillaume Perriard Laboratory Of Neuro-immunology, Neuroscience Research Center, University Hospital (chuv), Lausanne, Switzerland

498 - PROBING THE BIOCHEMICAL COMPOSITION OF NORMAL APPEARANCE WHITE MATTER, ACTIVE AND CHRONIC LESIONS FROM MULTIPLE SCLEROSIS CASES USING VIBRATIONAL SPECTROSCOPYInes Ramos (1) - Rachel Walter (2) - Julie Simpson (2) - Nicola Woodroofe (3) - Fiona Lyng (1)

Centre For Radiation And Environmental Science, Focas Research Institute, Dublin Institute Of Technology, Dublin, Ireland (1) Sheffield Institute For Translational Neuroscience, University Of Sheffield, Sheffield, United Kingdom (2) - Biomedical Research Centre, Sheffield Hallam University, Sheffield, United Kingdom (3)

238 - UV IRRADIATION-MEDIATED SYSTEMIC IMMUNE SUPPRESSION THROUGH AHR SIGNALLINGChiara Redaelli (1) - Caroline Pilz (1) - Anja Kunze (2) - Knut Schaekel (2) - Gernot Poschet (3) - Bernd Arnold (4) Wolfgang Wick (5) - Michael Platten (5)

Ccu Neuroimmunology And Brain Tumor Immunology, German Cancer Research Center, Heidelberg, Germany (1) - Laboratory Of Experimental Dermatology, Medical Faculty, University Heidelberg, Heidelberg, Germany (2) - Department Of Plant Molecular Biology, Centre For Organismal Studies, Heidelberg, Germany (3) - Department Of Molecular Immunology, German Cancer Research Center, Heidelberg, Germany (4) - Department Of Neurooncology, University Hospital Heidelberg, Heidelberg, Germany (5)

73

Scientific Program

86 - ANTI-INFLAMMATORY THERAPY VIA CD163-MACROPHAGES IN THE 6-OHDA PARKINSON’S DISEASE MODELNoemie Tentillier (1) - Anders Etzerodt (2) - Mads Olesen (1) - Filiz Sila Rizalar (1) - Søren K Moestrup (2) Marina Romero-ramos (1)

Cns Disease Modeling Group, Neurodin, Dept Biomedicine, Aarhus University, Aarhus, Denmark (1) Dept Biomedicine, Aarhus University, Aarhus, Denmark (2)

544 - AXONAL DAMAGE AND PROTECTION DURING EARLY REMYELINATION IN MULTIPLE SCLEROSIS AND AN ANIMAL MODELVerena Schultz - Uta Scheidt - Franziska Paap - Wolfgang Brueck - Andreas Junker Department Of Neuropathology, University Medical Center Goettingen, Goettingen, Germany

269 - EARLY SIGNS OF CELLULAR STRESS IN THE INDUCTION PHASE OF AUTOIMMUNE OPTIC NEURITISAleksandar Stojic - Sarah Williams - Ricarda Diem - Richard Fairless Neuro-oncology, University Clinic Heidelberg, Heidelberg, Germany

404 - THE SPHINGOSINE-1-PHOSPHATE RECEPTOR AGONIST FTY720 PROMOTES PERIPHERAL NERVE REGENERATIONFabian Szepanowski - Angelika Derksen - Gerd Meyer Zu Hörste - Hans-peter Hartung - Bernd C. Kieseier Department Of Neurology, Heinrich Heine University, Düsseldorf, Germany

46 - CORRELATION OF CONCENTRATIONS OF GLUTAMATE IN SERUM SAMPLES AND DISABILITY IN MULTIPLE SCLEROSISEkaterina Terskikh (1) - Valentina Alifirova (1) - Svetlana Ivanova (2) - Anastasia Ryazantseva (1) - Marina Titova (1) Irina Zhukova (1) - Anastasia Boyko (2)

Syberian State Medical University, Hospital Of Syberian State Medical University, Tomsk, Russian Federation (1) - Institute Of Mental Health, Hospital Of Institute Of Mental Health, Tomsk, Russian Federation (2)

511 - EVALUATION OF HUMORAL AUTOIMMUNITY IN EXPERIMENTAL CERVICAL SPINAL CORD INJURYAntigona Ulndreaj (1) - Apostolia Tzekou (2) - Andrea J. Mothe (3) - Mohammad Khazaei (2) - Charles H. Tator (1) Michael G. Fehlings (1)

Institute Of Medical Science, University Of Toronto, Toronto, Canada (1) - Division Of Genetics And Development, Toronto Western Research Institute, Toronto, Canada (2) - Division Of Genetics And Development, Toronto Western Research Institute, Toronto, Canada (3)

644 - GPR84 DEFICIENCY REDUCES MICROGLIOSIS, BUT ACCELERATES DENDRITIC DEGENERATION AND COGNITIVE DECLINE IN A MOUSE MODEL OF ALZHEIMER’S DISEASELusine Bozoyan - Julie Audoy-rémus - Aline Dumas - Mohammed Filali - Steve Lacroix - Serge Rivest Marie-ève Tremblay - Luc Vallières Laval University, Chu De Québec, Québec, Canada

COFFEE BREAK & POSTER SESSION | REPAIR 15:15 - 16:45 POSTERHALL (RHEINFOYER)

171 - PLASTIC RESPONSE OF MATURE OLIGODENDROCYTES FOLLOWING CNS DAMAGEGiuseppe Locatelli (1) - Arianna Baggiolini (2) - Bettina Schreiner (2) - Burkhard Becher (2) - Thorsten Buch (3)

Institute Of Clinical Neuroimmunology, Ludwig-maximilian Universität München, Zürich, Germany (1) - Institute Of Experimental Immunology, University Of Zürich, Zurich, Switzerland (2) - Institute For Medical Microbiology, Immunology And Hygiene, Technische Universität München, Munich, Germany (3)

292 - REGULATORY T CELLS PROMOTE CNS MYELIN REGENERATION IN VIVOYvonne Dombrowski (1) - Thomas O’hagan (1) - Marie Dittmer (1) - Peter Bankhead (2) - Anna Williams (3) Rebecca J. Ingram (1) - Chao Zhao (4) - Robin Jm Franklin (4) - Denise Fitzgerald (1)

Centre For Infection And Immunity, Queen’s University Belfast, Belfast, United Kingdom (1) - Centre For Cancer Research And Cell Biology, Queen’s University Belfast, Belfast, United Kingdom (2) - Mrc Centre For Regenerative Medicine, University Of Edinburgh, Edinburgh, United Kingdom (3) - Wellcome Trust-mrc Cambridge Stem Cell Institute, University Of Cambridge, Cambridge, United Kingdom (4)



178 - DIFFERENTIAL SCREENING-SELECTED GENE ABERRATIVE IN NEUROBLASTOMA (DAN) PRODUCTION IN CNS OF MS PATIENTS MAY SUPPORT NEUROGENESIS/ OLIGODENDROGENESISKeren Regev (1) - Karin Fainberg (1) - Olga Dorman (1) - Avi Gadoth (2) - Arnon Karni (3)

Neuroimmunology Laboratory, Tel Aviv Medical Center, Tel Aviv, Israel (1) - Depatment Of Neurology, Tel Aviv Medical Center, Tel Aviv, Israel (2) - Neuroimmunology Laboratory, Tel Aviv Medical Center, Sackler’s Medical School, Tel Aviv University, Tel Aviv, Israel (3)

173 - ENHANCEMENT OF THE ACTIVITY OF M2-POLARIZED MACROPHAGES/MICROGLIA PROMOTES RECOVERY FROM DEMYELINATION Manoj Mishra - Khalil Rawji - Michael B. Keough - Yan Fan - V. Wee Yong Hotchkiss Brain Institute, University Of Calgary, Calgary, Canada

COFFEE BREAK & POSTER SESSION | STEM CELLS 15:15 - 16:45 POSTERHALL (RHEINFOYER)

284 - NEURAL STEM CELL TRANSPLANTATION PROMOTES POST-ISCHEMIC NEURONAL PLASTICITY BY REGULATING THE EXPRESSION OF GLUTAMATE TRANSPORTERS.Marco Bacigaluppi (1) - Gianluca Luigi Russo (1) - Luca Peruzzotti-jametti (1) - Silvia Rossi (2) - Erica Butti (1) Roberta De Ceglia (1) - Caterina Motta (2) - Luca Muzio (1) - Giancarlo Comi (1) - Diego Centonze (2) Roberto William Invernizzi (3) Dirk Matthias Hermann (4) - Gianvito Martino (1)

Neuroimmunology Unit, Institute Of Experimental Neurology, University Vita Salute San Raffaele And San Raffaele Hospital, Milan, Italy (1) - Department Of Neuroscience, Neurologic Clinic, Tor Vergata University, Rome, Italy (2) - Neurochemistry And Behavior, Irccs-istituto Di Ricerche Farmacologiche “mario Negri”, Milano, Italy (3) - Department Of Neurology, University Hospital Essen, Essen, Germany (4)

589 - MESENCHYMAL STEM CELLS NANOVESICLES: AN INNOVATIVE THERAPEUTIC APPROACH FOR NEUROPROTECTION AND NEUROREGENERATIONBruno Bonetti (1) - Alessia Farinazzo (1) - Stefano Angiari (2) - Ermanna Turano (1) - Elena Bazzoli (1) Gabriela Constantin (2)

Dept Of Neuroscience, University Of Verona, Verona, Italy (1) - Dept Of Pathology, University Of Verona, Verona, Italy (2)

514 - INTRATHECAL TRANSPLANTATION OF NEURAL PRECURSOR CELLS IMPAIRS THE EFFECTOR PHASE OF EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS.Donatella De Feo (1) - Arianna Merlini (1) - Elena Brambilla (1) - Cecilia Laterza (1) - Francesca Ruffini (1) - Ramesh Menon (1) - Cinthia Farina (1) - Giancarlo Comi (1) - Melanie Greter (2) - Gianvito Martino (1)

Neuroimmunology Unit, Institute Of Experimental Neurology, University Vita Salute San Raffaele And San Raffaele Hospital, Milan, Italy (1) - Institute Of Experimental Immunology, University Of Zurich, Zürich, Switzerland (2)

586 - IS INTRA-MUSCULAR TRANSPLANTATION OF HUMAN PLACENTAL STROMAL CELLS A FEASIBILE APPROACH FOR CELL THERAPY IN MULTIPLE SCLEROSIS?Nina Fainstein (1) - Ilona Shapiro (1) - Maria Tzirlin (2) - Tamir Ben-hur (1) - Raphael Gorodetsky (2)

Department Of Neurology, Hadassah Hebrew University Medical Center, Jerusalem, Israel (1) - Department Of Oncology, Hadassah Hebrew University Medical Center, Jerusalem, Israel (2)

409 - THE CANNABINOID SYSTEM IN HUMAN MESENCHYMAL CELLSCoral González García (1) - Laura Román Vega (1) - Lucía Campos Ruíz (1) - Elvira Ramil Tojeiro (1) - Mercedes Zurita Castillo (2) - Concepción Aguayo Ferrer (2) - Antonio J. Sánchez López (1) - Juan Antonio García-merino (1)

University Hospital Puerta De Hierro Research Institute (neuroimmunology Unit), Hospital Puerta De Hierro, Majadahonda/ Madrid, Spain (1) - University Hospital Puerta De Hierro Research Institute (neuroscience Unit), Hospital Puerta De Hierro, Majadahonda/ Madrid, Spain (2)

415 - THERAPEUTIC POTENTIAL OF HUMAN MESENCHYMAL CELLS FROM MULTIPLE SCLEROSIS PATIENTS IN EAECoral González García (1) - Laura Román Vega (1) - Lucía Campos Ruíz (1) - Elvira Ramil Tojeiro (1) - Mercedes Zurita Castillo (2) - Concepción Aguayo Ferrer (2) - Antonio J. Sánchez López (1) - Juan Antonio García-merino (1)

University Hospital Puerta De Hierro Research Institute (neuroimmunology Unit), Hospital Puerta De Hierro, Majadahonda/ Madrid, Spain (1) - University Hospital Puerta De Hierro Research Institute (neuroscience Unit), Hospital Puerta De Hierro, Majadahonda/ Madrid, Spain (2)

75

Scientific Program

289 - EXTRACELLULAR VESICLES FROM NEURAL STEM CELLS TRANSFER THE IFN-γ/IFNGR1 COMPLEX TO ACTIVATE STAT1-DEPENDENT SIGNALLING IN TARGET CELLSNunzio Iraci (1) - Chiara Cossetti (1) - Tim Mercer (2) - Tommaso Leonardi (3) - Emanuele Alpi (4) - Denise Drago (4) Clara Alfaro-cervello (1) - Harpreet Saini (3) - Matthew Davis (3) - Julia Schaeffer (1) - Werner Muller (5) - Jose Manuel Garcia-verdugo (6) - Suresh Mathivanan (7) - Angela Bachi (4) - Anton Enright (3) - John Mattick (8) - Stefano Pluchino (1)

Clinical Neurosciences, University Of Cambridge, Cambridge, United Kingdom (1) - Institute For Molecular Bioscience, University Of Queensland, St Lucia, Australia (2) - The Embl-european Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom (3) - Biomolecular Mass Spectrometry Unit, Division Of Genetics And Cell Biology, San Raffaele Scientific Institute, Milan, Italy (4) - Faculty Of Life Sciences, University Of Manchester, Manchester, United Kingdom (5) - Departamento De Neurobiología Comparada, Universidad De Valencia, Valencia, Spain (6) - Department Of Biochemistry, La Trobe University, Victoria, Australia (7) The Garvan Institute, The Garvan Institute, Darlinghurst, Australia (8)

101 - MESENCHYMAL STEM CELLS (MSC) DERIVED FROM MICE WITH EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS (EAE) SUPPRESS EAE AND HAVE SIMILAR BIOLOGICAL PROPERTIES WITH MSC FROM HEALTHY DONORSIbrahim Kassis Kassis - Panayiota Petrou - Dimitrios Karussis Hadassah-hebrew University Medical Center, Hadassah-hebrew University Medical Center, Jerusalem, Israel

453 - GENERATION AND CHARACTERIZATION OF IPSC-DERIVED NEURONS FROM MULTIPLE SCLEROSIS PATIENTSCecilia Laterza (1) - Roberta De Ceglia (1) - Lorenzo Pinzani (1) - Francesca Ruffini (1) - Chiara Paola Zoia (2) Michael Peitz (3) - Gianvito Martino (1)

Neuroimmunology Unit, Inspe, Ospedale San Raffaele, Milano, Italy (1) - Department Of Surgery & Translational Medicine, University Of Milano-bicocca, Monza, Italy (2) - Institute Of Reconstructive Neurobiology, University Of Bonn, Bonn, Germany (3)

433 - ANALYSIS OF THE INTERFERON GAMMA MODULATED PATHWAYS RELATED TO THE THERAPEUTIC PLASTICITY OF BONE MARROW-DERIVED MESENCHYMAL STEM CELLS THROUGH A SILAC-BASED PROTEOMIC APPROACHLaura Lovato (1) - Cristina Neri (2) - Valeria Marzano (3) - Giovanni Novi (1) - Stefano Levi Mortera (2) - Chiara Cavaliere (4) Anna Laura Capriotti (4) - Luisa Pieroni (2) - Nicole Kerlero De Rosbo (1) - Andrea Urbani (2) - Antonio Uccelli (1)

Department Of Neurology, Ophtalmology And Genetics, University Of Genoa, Genoa, Italy (1) - Proteomic And Metabonomic Laboratory, Santa Lucia Foundation, Rome, Italy (2) - Department Of System Medicine And Department Of Experimental Medicine And Surgery, University Of Rome Tor Vergata, Rome, Italy (3) - Department Of Chemistry, Sapienza University, Rome, Italy (4)

262 - INFLUENCE OF EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS ON THE LOCALIZATION AND VIABILITY OF NEURAL STEM CELLS AFTER INTRATHECAL TRANSPLANTATIONArianna Merlini (1) - Donatella De Feo (1) - Francesca Ruffini (1) - Elena Brambilla (1) Giancarlo Comi (2) - Gianvito Martino (1)

Neuroimmunology Unit, Institute Of Experimental Neurology, San Raffaele Scientific Institute, Milan, Italy (1) Department Of Neurology And Institute Of Experimental Neurology, San Raffaele Scientific Institute, Milan, Italy (2)

218 - CYTOKINES PRODUCTION IN MULTIPLE SCLEROSIS PATIENTS AFTER INTRAVENOUS INFUSION OF AUTOLOGOUS MESENCHYMAL STEM CELLSDarya Nizheharodava - Mariya Yurkevich - Halina Ivanchyk - Svetlana Kulinich - Marina Zafranskaya Belarussian Medical Academy Of Post-graduate Education, Bio-medical Research Center, Minsk, Republic Of Belarus

581 - STUDY OF PHENOTYPΒC CHANGES IN CORTICAL NEURON CULTURES INDUCED BY MESENCHYMAL STEM CELLS CM DURING NEUROPROTECTION AGAINST GLUTAMATE-INDUCED CELL DEATHIrini PapazianHellenic Pasteur Institute, Laboratory Of Molecular Genetis, Athens, Greece

50 - INJECTION OF NEXT-GENERATION DIRECTLY-INDUCED NEURAL STEM CELLS (INSCS) INDUCES RECOVERY IN A MOUSE MODEL OF MULTIPLE SCLEROSISLuca Peruzzotti-jametti (1) - Giulia Mallucci (1) - Gillian Tannahill (1) - Bing Huang (1) - Yenal Bernard Lakes (2) Elena Giusto (1) - Matteo Donega’ (1) - Beatrice Balzarotti (1) - Frank Edenhofer (3) - Stefano Pluchino (1)

John Van Geest Centre For Brain Repair And Wellcome Trust-medical Research Council Stem Cell Institute, Department Of Clinical Neurosciences, University Of Cambridge, Cambridge, United Kingdom (1) - Institute Of Reconstructive Neurobiology, University Of Bonn, Bonn, Germany (2) - Institute For Anatomy And Cell Biology, University Of Würzburg, Würzburg, Germany (3)



230 - EFFECTS OF INTERFERON-BETA ON NEURAL STEM CELLS AND IN A MOUSE MODEL OF MULTIPLE SCLEROSISSarah Stahlke (1) - Judith Metzdorf (2) - Xiomara Pedreitturia (1) - Simon Van Leeuwen (3) - Andreas Faissner (3) Ralf Gold (1) - Ingo Kleiter (1)

Neuroimmunologie, St. Josef Hospital, Bochum, Germany (1) - Neuroimmunologie, Ruhr-universität, Bochum, Germany (2) Zellmorphologie Und Molekulare Neurobiologie, Ruhr-universität, Bochum, Germany (3)

349 - CHARACTERIZATION OF AD-MSC GENETICALLY MODIFIED TO PRODUCE IFNBETA. EFFECTIVENESS IN RR-EAE MODELMargarita Suardíaz García (1) - Carmen Marín-bañasco (1) - Karim Benabdellah (2) - Laura Leyva Fernandez (1) Begoña Oliver Martos (1) - Maria Jesus Pinto Medel (1) - Francisco Martín Molina (2) - Oscar Fernández Fernández (3)

Instituto De Biomedicina De Málaga (ibima), H.r.u. Of Málaga, U.g.c. Of Neuroscience, Research Laboratory, Málaga, Spain (1) - Genyo. Centre For Genomics And Oncological Research:, University Of Granada/andalucian Regional Government, Pts Granada., Granada, Spain (2) - Instituto De Biomedicina De Málaga (ibima), H.r.u. Of Málaga, U.g.c. Of Neuroscience, Málaga, Spain (3)

428 - INVESTIGATION OF THE IMPACT OF INTRAVENOUS INJECTION OF MESENCHYMAL STEM CELLS FROM MOUSE BONE MARROW ON MUSCLE WEAKNESS AND IMMUNOLOGICAL PARAMETERS IN EXPERIMENTAL AUTOIMMUNE MYASTHENIA GRAVIS MODELCanan Aysel Ulusoy (1) - Melike Kucukerden (1) - Selin Turan (1) - Gulben Gurkan (2) - Ismail Ogulur (2) Tunc Akkoc (2) - Erdem Tuzun (1)

Institute For Experimental Medicine, Istanbul University, Istanbul, Turkey (1) - Marmara Medical Faculty, Marmara University, Istanbul, Turkey (2)

487 - BONE MARROW MESENCHYMAL STEM CELL-DERIVED SECRETED FACTORS PROMOTE THE PROLIFERATION OF ADULT SUBVENTRICULAR ZONE-NEURAL STEM CELLS AND FOSTER THEIR STEMNESS IN VITRO UNDER PATHOGENIC CONDITIONS.Androniki Voulgari-kokota (1) - Annalisa Buffo (2) - Nicole Kerlero De Rosbo (1) - Antonio Uccelli (1)

Department Of Neuroscience, Ophthalmology And Genetics, University Of Genoa, Genoa, Italy (1) - Dept. Of Neuroscience, Neuroscience Institute Cavalieri Ottolenghi (nico), University Of Turin Regione Gonzole 10, Turin, Italy (2)

COFFEE BREAK & POSTER SESSION | T-CELLS 15:15 - 16:45 POSTERHALL (RHEINFOYER)

371 - CHEMOKINE RECEPTOR CCR7 ON CD4+ T CELLS PLAYS A CRUCIAL ROLE IN THE INDUCTION OF EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITISPatrick Belikan - Ulrike Buehler - Jérôme Birkenstock - Christina Wolf - Frauke Zipp - Volker Siffrin Department Of Neurology, University Medical Center Of The Johannes Gutenberg University Of Mainz, Mainz, Germany

425 - CD4+ T AFFINITY AND CROSS-REACTIVITY BETWEEN MOG AND NFM DURING THE POLYCLONAL RESPONSE OF MOG INDUCED DEMYELINATING AUTOIMMUNE DISEASELori Blanchfield - Brian Evavold Emory University, Department Of Microbiology And Immunology, Atlanta, Georgia, United States

278 - CCL2 CHEMOKINE IN T CELL TOLERANCE AND PROTECTION AGAINST EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITISOriane Cédile (1) - Morten Løbner (1) - Henrik Toft-hansen (1) - Ida Frank (1) - Agnieszka Wlodarczyk (1) Magali Irla (2) - Trevor Owens (1)

Institute Of Molecular Medicine, University Of Southern Denmark, Odense, Denmark (1) Centre D’immunologie De Marseille-luminy – Ciml, Aix Marseille Université 2, Marseille, France (2)

224 - DEEP SEQUENCING OF T-CELL RECEPTOR REPERTOIRE REVEALS ENRICHMENT OF HIGHLY EXPANDED CLONOTYPES IN CEREBROSPINAL FLUID FROM MULTIPLE SCLEROSISAlessandra De Paula Alves Sousa (1) - Richard Nicholas (2) - Kory Johnson (1) - Sam Darko (3) - David Price (4) Daniel Douek (3) - Paolo Muraro (5) - Steven Jacobson (6)

National Institute Of Neurological Disorders And Stroke, Nih, Bethesda, United States (1) - Imperial College London, Ic, London, United Kingdom (2) - National Institute Of Allergy And Infectious Diseases, Nih, Bethesda, United States (3) - Cardiff University School Of Medicine, University Of Cardiff, Cardiff, United Kingdom (4) - Imperial College London, Ic, London, United Kingdom (5) - National Institute Of Neurological Disorders And Stroke, Nih, Brethesda, United States (6)

77

Scientific Program

502 - INFLUENCE OF REGULATORY T CELLS ON OLIGODENDROCYTE LINEAGE CELLS IN VITROMarie Dittmer (1) - Thomas O’hagan (1) - Peter Bankhead (2) - Yvonne Dombrowski (1) - Denise C. Fitzgerald (1)

Centre For Infection And Immunity, Queen’s University Belfast, Belfast, United Kingdom (1) - Centre For Cancer Research And Cell Biology, Queen’s University Belfast, Belfast, United Kingdom (2)

99 - HUMAN T CELLS IN SILICO: MODELLING THE ELECTROPHYSIOLOGICAL BEHAVIOUR OF T CELLS IN HEALTH AND DISEASEPetra Ehling (1) - Patrick Meuth (1) - Paul Eichinger (1) - Alexander Herrmann (1) - Tatyana Kanyshkova (2) Stefan Bittner (1) - Thomas Budde (2) - Sven G. Meuth (1)

Neurology, University, Münster, Germany (1) - Physiology I, University, Münster, Germany (2)

295 - ROLE OF NUCLEAR RECEPTORS IN DIFFERENTIATION OF MOG-SPECIFIC TH17 CELLS AND MOG-INDUCED EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITISHans Faber (1) - Gurumoorthy Krishnamoorthy (2) - Helena S. Domingues (2) - Peter Weber (1) Benno Pütz (1) - Frank Weber (1)

Max Planck Institute, Of Psychiatry, Munich, Germany (1) - Max Planck Institute Of Neurobiology, Department Of Neuroimmunology, Martinsried, Germany (2)

626 - HIGH EXPRESSION OF CYTOTOXIC MOLECULES AND TH1 BIAS OF CIRCULATING T CELLS IN PATIENTS WITH MULTIPLE SCLEROSIS UNDER FINGOLIMOD TREATMENTChihiro Fujii (1) - Yoichiro Okada (2) - Kimitoshi Kimura (2) - Masanori Nakagawa (1) - Sadayuki Matsumoto (3) Ryosuke Takahashi (2) - Hirofumi Ochi (4) - Takayuki Kondo (2) - Toshiki Mizuno (1)

Department Of Neurology, Graduate School Of Medical Science, Kyoto Prefectural University Of Medicine, Kyoto, Japan (1) Department Of Neurology, Kyoto University Graduate School Of Medicine, Kyoto, Japan (2) - Department Of Neurology, Tazuke Kofukai Foundation, Medical Research Institute, Kitano Hospital, Osaka, Japan (3) - Department Of Neurology And Geriatric Medicine, Ehime University Graduate School Of Medicine, Toon, Japan (4)

583 - DEFECTIVE CD55 COSTIMULATION IN MULTIPLE SCLEROSIS - A PRELIMINARY STUDY.Ruhcha Sutavani (1) - Bruno Gran (2) - Ian Spendlove (3)

College Of Life Sciences, University Of Dundee, Dundee, United Kingdom (1) - Division Of Clinical Neuroscience, University Of Nottingham School Of Medicine, Nottingham, United Kingdom (2) - Division Of Cancer And Stem Cells, University Of Nottingham School Of Medicine, Nottingham, United Kingdom (3)

129 - T CELL RECEPTORS OF “MUCOSAL-ASSOCIATED INVARIANT T” CELLS IN MULTIPLE SCLEROSIS BRAIN LESIONSKathrin Held (1) - Latika Bhonsle (1) - Wakiro Sato (1) - Geraldine Rühl (1) - David Axel Laplaud (2) Reinhard Hohlfeld (1) - Klaus Dornmair (1)

Institute For Clinical Neuroimmunology, Klinikum Der Universität München, München, Germany (1) Service De Neurologie, Chu De Nantes, Nantes, France (2)

517 - T CELL RESPONSES TO THE INWARD RECTIFYING POTASSIUM CHANNEL KIR4.1 IN MULTIPLE SCLEROSIS PATIENTSSudhakar Reddy Kalluri - Anita Krysta - Rajneesh Srivastava - Carina Novak - Rebecca Selter - Verena Loleit Viola Biberacher - Dorothea Buck - Thomas Korn - Bernhard Hemmer Department Of Neurology, Klinikum Rechts Der Isar, Technische Universität, Munich, Munich, Germany

617 - INDUCTION OF PRO-INFLAMMATORY CYTOKINE PRODUCTION IN THYMOCYTES BY THE IMMUNE RESPONSE MODIFIERS IMIQUIMOD AND GARDIQUIMOD™Harald Hofstetter - Andreas Weber - Corinna Zimmermann - Bernd Kieseier - Hans Peter Hartung Department Of Neurology, Heinrich Heine University, Düsseldorf, Germany 211 - IN VIVO MAINTENANCE OF HUMAN REGULATORY T CELLS DURING CD25 BLOCKADE.David J. Huss (1) - Devangi S. Mehta (2) - Akanksha Sharma (1) - Xiaojun You (3) - Katherine A. Riester (3) James P. Sheridan (4) - Lakshmi S. Amaravadi (2) - Jacob S. Elkins (5) - Jason D. Fontenot (1)

Immunology Research, Biogen Idec, Cambridge, United States (1) - Translational Sciences, Biogen Idec, Cambridge, United States (2) Biostatistics, Biogen Idec, Cambridge, United States (3) - Translational Medicine, Abbvie Biotherapeutics Inc., Redwood City, United States (4) - Clinical Development, Biogen Idec, Cambridge, United States (5)



359 - CANNABIDIOL EFFECTS ON MRNA LEVELS AND SIGNALING PATHWAYS IN MOG-35-55 ACTIVATED ENCEPHALITOGENIC T CELLSEwa Kozela (1) - Nathali Kaushansky (2) - Giovanni Coppola (3) - Daniel Geschwind (3) - Zvi Vogel (1) - Ana Juknat (1)

Sackler School Of Medicine, Tel Aviv University, Tel Aviv, Israel (1) - Neurobiology Department, Weizmann Institute Of Science, Rehovot, Israel (2) - Department Of Neurology, Ucla, Los Angeles, United States (3)

329 - THE ROLE OF NFKAPPAB INDUCING KINASE (NIK) IN THE PATHOGENICITY OF EAESonja Lacher (1) - Florian Mair (2) - Nicole Israel (1) - Sabrina Rodewald (1) - Burkhard Becher (2) - Ari Waisman (1)

Institute For Molecular Medicine, University Medical Center Of The Johannes Gutenberg-university Mainz, Mainz, Germany (1) Institute Of Experimental Immunology, University Of Zurich, Zürich, Switzerland (2)

175 - CHEMOKINE-INDUCED TRAFFICKING OF T CELLS INTO THE MENINGES THROUGH THE BRAIN “GATES”Antoine Louveau - Sachin Gadani - Tajie Harris - Jonathan Kipnis Center For Brain Immunology And Glia, Department Of Neuroscience, University Of Virginia, Charlottesville, United States

216 - CRITICAL ROLE OF THYMOCYTE-DERIVED BRAIN-DERIVED NEUROTROPHIC FACTOR IN T CELL MATURATIONFred Lühder (1) - Ralf Linker (2) - De-hyung Lee (2) - Holger Reichardt (3) - Ursula Bommhardt (4) - Ralf Gold (5) Alexander Flügel (1)

Department Of Neuroimmunology, Institute For Multiple Sclerosis Research, University Of Göttingen, Göttingen, Germany (1) Department Of Neurology, Friedrich-alexander University Erlangen, Erlangen, Germany (2) - Department Of Cellular And Molecular Immunology, University Of Göttingen, Göttingen, Germany (3) - Institute For Molecular And Clinical Immunology, Otto-guericke University Magdeburg, Magdeburg, Germany (4) - Department Of Neurology, St. Josef-hospital/ruhr-university Bochum, Bochum, Germany (5)

471 - COGNITIVE PERFORMANCE AMONG OLDER INDIVIDUALS ASSOCIATED WITH THE PERIPHERAL EFFECTOR MEMORY CD4+ T CELLSCláudia Miranda - Susana Roque - Nadine Santos - Carlos Portugal-nunes - Patrício Costa - Joana Palha Nuno Sousa - Margarida Correia-neves Life And Health Sciences Research Institute (icvs), School Of Health Sciences, University Of Minho, Braga, Portugal

470 - IN VIVO VISUALIZATION OF THE ROLE OF CHEMOKINES IN MIGRATORY T CELLS DURING CNS INFLAMMATION.Francesca Odoardi - Christian Schläger - Henrike Körner - Michael Haberl - Dmitri Lodygin - Alexander Flügel Institute For Multiple Sclerosis Research, Department Of Neuroimmunology,university Medical Centre Göttingen, Göttingen, Germany

510 - THE ROLE OF SOLUBLE FACTORS SECRETED FROM TREG CELLS IN CENTRAL NERVOUS SYSTEM MYELINATIONThomas P O’hagan (1) - Yvonne Dombrowski, (1) - Peter Bankhead (1) - Eimear Linehan (1) - Adrien Kissenpfennig (1) Anna Williams (2) - Denise C Fitzgerald (1)

Cii, The Queen’s University Belfast, Belfast, United Kingdom (1) - Mrc Centre For Regenerative Medicine, The University Of Edinburgh, Edinburgh, United Kingdom (2)

130 - VAV1 CONTROLS INFLAMMATION IN EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS (EAE)Andre Ortlieb Guerreiro-cacais (1) - Marie N’diaye (1) - Rasmus Berglund (1) - Amennai Daniel Beyeen (2) Maja Jagodic (1) - Tomas Olsson (1)

Neuroimmunology Unit, Department Of Clinical Neuroscience, Karolinska University Hospital, Stockholm, Sweden (1) Novartis, Novartis, Stockholm, Sweden (2)

547 - PROPERTIES AND MOLECULAR CHARACTERISTIC OF IMMUNE REGULATION OFHUMAN THYMUS-DERIVED CD4+HLA-G+ REGULATORY T CELLS IN VITRO AND IN VIVOSusann Pankratz - Alexander M. Herrmann - Stefan Bittner - Sven G. Meuth - Heinz Wiendl Department Of Neurology, University Of Muenster, Muenster, Germany

236 - METHODOLOGICAL APPROACH TO IDENTIFY AND ISOLATE DISEASE RELEVANT BRAIN-INFILTRATING T CELL CLONES IN MULTIPLE SCLEROSIS PATIENTSRaquel Planas (1) - Yaneth Ortiz (1) - Imke Metz (2) - Núria Vilarrasa (1) - Brenda Reinhart (1) - Christoph Heesen (3) Wolfgang Brück (2) - Roland Martin (1) - Mireia Sospedra (1)

Neuroimmunology And Multiple Sclerosis Research Section, Department Of Neurology, University Hospital Zurich, Zurich, Switzerland (1) Department Of Neuropathology, University Medical Center, Georg August University, Göttingen, Germany (2) - Institute For Neuroimmunology And Clinical Ms Research (inims), University Medical Center Hamburg-eppendorf, Hamburg, Germany (3)

79

Scientific Program

69 - OXYSTEROLS ARE EXPRESSED IN T LYMPHOCYTES AND IMPAIR TYPE 1 REGULATORY CD4 T-CELL DIFFERENTIATIONFanny Chalmin (1) - Nishta Budoo (2) - Rochemont Viviane (2) - Doron Merkler (2) - Caroline Pot (1)

Department Of Neurology, Geneva University Hospitals, Geneva, Switzerland (1) - Department Of Pathology And Immunology, Geneva University, Geneva, Switzerland (2)

607 - INVESTIGATING THE OREXIN/HYPOCRETIN SPECIFIC T CELL RESPONSE IN PATIENTS WITH NARCOLEPSY WITH CATAPLEXYMelanie Ramberger - Birgit Högl - Thomas Mitterling - Birgit Frauscher - Markus Reindl - Andreas Lutterotti Clinical Department Of Neurology, Innsbruck Medical University, Innsbruck, Austria

115 - CENTRAL NERVOUS SYSTEM REPAIR REQUIRES BOTH EFFECTOR AND REGULATORY T CELLS WITH DISTINCT TEMPORAL AND SPATIAL PROFILESCatarina Raposo - Michal Schwartz Weizmann Institute Of Science, Department Of Neurobiology, Rehovot, Israel

378 - NR4A2 CONTROLS PATHOGENIC “SWITCHED” TH17 CELLS IN THE CNS DURING AUTOIMMUNE INFLAMMATIONBen Raveney - Shinji Oki - Takashi Yamamura National Institute Of Neuroscience, Ncnp, Tokyo, Japan

486 - CD8 T CELL RECRUITMENT IN THE NORMAL AGING CNSRodney Ritzel - Anita Patel - Josh Crapser - Louise Mccullough University Of Connecticut Health Center, University Of Connecticut Health Center, Farmington, United States

548 - PLASMACYTOID DENDRITIC CELLS INDUCE AN IMMUNOREGULATORY T HELPER 9 PROFILE IN MULTIPLE SCLEROSISGabriella Ruocco (1) - Silvia Rossi (2) - Caterina Motta (2) - Giulia Macchiarulo (2) - Francesca Barbieri (2) - Marco De Bardi (1) Giovanna Borsellino (1) - Maria Grazia Grasso (3) - Serena Ruggieri (4) - Claudio Gasperini (4) - Roberto Furlan (5) Diego Centonze (2) - Luca Battistini (1) - Elisabetta Volpe (1)

Neuroimmunology Unit, Santa Lucia Foundation, Rome, Italy (1) - Neuroimmunology And Synaptic Plasticity Laboratory Units - Department Of Neuroscience, Santa Lucia Foundation - University Tor Vergata, Rome, Italy (2) - Multiple Sclerosis Centre, Santa Lucia Foundation, Rome, Italy (3) - Department Of Neuroscience “lancisi”, San Camillo Hospital, Rome, Italy (4) - Neuroimmunology Unit, San Raffaele Scientific Institute, Milan, Italy (5)

398 - IS THERE A CORRELATION BETWEEN CD39+CD25+ T LYMPHOCYTES AND FOXP3 ISOFORMS IN MULTIPLE SCLEROSIS?Manolo Sambucci (1) - Francesca Gargano (1) - Marco De Bardi (1) - Claudio Gasperini (2) - Serena Ruggieri (2) Veronica De Rosa (3) - Giuseppe Matarese (4) - Giovanna Borsellino (1) - Luca Battistini (1)

Neuroimmunology Unit, Irccs Santa Lucia Foundation, Rome, Italy (1) - Department Of Neuroscience “lancisi”, San Camillo Hospital, Rome, Italy (2) - Laboratorio Di Immunologia, Istituto Di Endocrinologia E Oncologia Sperimentale, Consiglio Nazionale Delle Ricerche (ieos-cnr), Napoli, Italy (3) - Department Of Medicine And Surgery, University Of Salerno, “baronissi Campus”, Salerno, Italy (4)

33 - ALPHA-SYNUCLEIN IMMUNIZATION, IN ABSENCE OF ALPHA-SYNUCLEIN OVER-EXPRESSION OR NEURAL PATHOLOGY, MODIFIES MICROGLIA ACTIVATION PATTERNS AND T CELLS’ ACTIVATION PROFILESMarina Romero-ramos (1) - Josefine Christiansen (1) - Vanesa Sanchez-guajardo (2)

Cns Disease Modeling Group, Neurodin, Department Of Biomedicine, Aarhus University, Aarhus, Denmark (1) - Neuroimmunology Of Degenerative Disease Group , Neurodin, Department Of Biomedicine, Aarhus University, Aarhus, Denmark (2)

188 - CHEMOKINE RECEPTOR EXPRESSIONS ON T CELLS IN CHRONIC INFLAMMATORY DEMYELINATING POLYNEUROPATHYWakiro Sato (1) - Toshimasa Aranami (1) - Norio Chihara (1) - Ryotaro Ikeguchi (1) - Tomoko Okamoto (2) Takashi Yamamura (1)

Department Of Immunology, National Institute Of Neuroscience, National Center Of Neurology And Psychiatry (ncnp), Tokyo, Japan (1) Department Of Neurology, National Center Hospital, National Center Of Neurology And Psychiatry (ncnp), Tokyo, Japan (2)



300 - LAQUINIMOD PREVENTS DISABILITY PROGRESSION IN A MODEL OF SPONTANEOUS CHRONIC EAE AND INTERFERES WITH DEVELOPMENT OF FOLLICULAR HELPER T CELLSMichel Varrin-doyer (1) - Ulf Schulze Topphoff (1) - Kara Pekarek (1) - Raymond A. Sobel (2) - Scott S. Zamvil (1)

Department Of Neurology, University Of California, San Francisco, San Francisco, United States (1) Department Of Pathology, Stanford University, Stanford, United States (2)

27 - CTLA-4IG TREATMENT AFTER IMMUNIZATION EXACERBATES EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITISIsabel Vogel - Ahmad Kasran - Stefaan Van Gool - Jan Ceuppens Ku Leuven, Department Of Microbiology And Immunology, Laboratory Of Clinical Immunology, Leuven, Belgium

49 - NEUROPROTECTIVE ROLE OF REGULATORY T CELLS IN PARKINSON’S DISEASE: EFFECT OF COP-1/ALPHA-SYNUCLEIN VACCINATION ON PATHOLOGY PROGRESSIONMarianne Von Euler Chelpin - Marina Romero-ramos - Vanesa Sanchez-guajardo Aarhus University, Dept. Biomedicine, Aarhus University, Aarhus, Denmark

576 - MITIGATED TREGS AND AUGMENTED TH17 CELLS AND CYTOKINES ARE ASSOCIATED WITH SEVERITY OF EXPERIMENTAL AUTOIMMUNE NEURITISXu Wang (1) - Xiang-yu Zheng (1) - Chi Ma (2) - Xiao-ke Wang (3) - Jiang Wu (1) - Abdu Adem (4) - Jie Zhu (1) Hong-liang Zhang (1)

Jilin University, Department Of Neurology, The First Hospital Of Jilin University, Changchun, China (1) - Jilin University, Department Of Neurosurgery, The First Hospital Of Jilin University, Changchun, China (2) - Jilin University, Department Of Neurosurgery, The Second Hospital Of Jilin University, Changchun, China (3) - United Arab Emirates University, Faculty Of Medicine And Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates (4)

368 - EXPRESSION OF THE G-PROTEIN COUPLED RECEPTOR EBI2 IN T CELLS IS HIGHLY REGULATED AND CONFERS PATHOGENICITY TO MYELIN SPECIFIC TH17 CELLSFlorian Wanke (1) - Andrew L. Croxford (2) - André P. Heinen (1) - Stephanie Firmenich (1) - Sonja Moos (1) Nicole Israel (1) - Denise Tischner (3) - Sonja Reißig (1) - Christian Reichhold (1) - Khalad Karram (1) - Ilgiz Mufazalov (1) Tanja Kuhlmann (4) - Nina Wettschureck (3) - Andreas Sailer (5) - Klaus Rajewski (6) - Stefano Casola (7) Ari Waisman (1) - Florian C. Kurschus (1)

Institute For Molecular Medicine, Johannes Gutenberg-university, Mainz, Germany (1) - Institute Of Experimental Immunology – Neuro- And Tumorimmunology, University Of Zurich, Zurich, Switzerland (2) - Department Of Pharmacology, Max-planck-institute For Heart And Lung Research, Bad Nauheim, Germany (3) - Institute For Neuropathology, University Of Münster, Münster, Germany (4) Developmental & Molecular Pathways, Novartis Institutes For Biomedical Research, Basel, Switzerland (5) Max-delbrück-center For Molecular Medicine, Max-delbrück-center For Molecular Medicine, Berlin, Germany (6) Ifom-ieo Campus, Ifom-ieo Campus, Milan, Italy (7)

147 - INHIBITING ERK NUCLEAR TRANSLOCATION IN TH17 CELLS LEADS TO DOWNREGULATION OF GM-CSF Katharina Birkner (1) - Mathias Engelhardt (1) - Maruf Hasan (1) - Vijay Tiwari (2) - Frauke Zipp (1) - Esther Witsch (1)

Universitätsmedizin Der Johannes Gutenberg-universität, Klinik Und Poliklinik Für Neurologie, Mainz, Germany (1) Institute Of Molecular Biology, Johannes Gutenberg-universität, Mainz, Germany (2)

109 - INTERACTION OF INTERFERON BETA-1B AND CXCR4 ON T CELLS IN MULTIPLE SCLEROSISTanja Wostradowski (1) - Viktoria Gudi (1) - J.a. Lindquist (2) - Sabine Lindquist (3) - Martin Stangel (1)

Clinic Of Neurology, Medical School Hannover, Hannover, Germany (1) - Department Of Nephrology, Hypertension, Diabetes, And Endocrinology, Otto-von-guericke- University, Magdeburg, Germany (2) - Department Of Neurochemistry And Molecular Biology, Leibniz-institute For Neurobiology, German Center For Neurodegenerative Disorders, Magdeburg, Germany (3)

462 - IFN-GAMMA RESPONSE AGAINST MEASLES VIRUS PEPTIDES IN SUBACUTE SCLEROSING PANENCEPHALITIS PATIENTSSibel P. Yentür (1) - Suzan Adin-cinar (2) - Candan Gürses (3) - Veysi Demirbilek (4) - Safa Baris (5) - Semih Ayta (6) Ümit Kuru (7) - Zuhal Yapici (3) - Serap Uysal (8) - Ozlem Cokar (9) - Aysen Gokyigit (3) - Guher Saruhan-direskeneli (1)

Department Of Physiology, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey (1) - Institute For Experimental And Medical Research, Department Of Immunology, Istanbul University, Istanbul, Turkey (2) - Department Of Neurology, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey (3) - Department Of Neurology, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey (4) Department Of Pediatrics, Marmara Medical Faculty, Marmara University, Istanbul, Turkey (5) - Department Of Neurology, Maltepe Medical Faculty, Maltepe University, Istanbul, Turkey (6) - Department Of Pediatrics, Bayrampasa Hospital, Istanbul, Turkey (7) Department Of Pediatrics, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey (8) - Department Of Neurology, Haseki Hospital, Istanbul, Turkey (9)

81

Scientific Program

464 - DIFFERENTIAL CYTOKINE CHANGES IN MYASTHENIA GRAVIS PATIENTS WITH ANTIBODIES AGAINST ACHR AND MUSKVuslat Yilmaz (1) - Piraye Oflazer (2) - Fikret Aysal (3) - Hacer Durmus (2) - Kostas Poulos (4) - Yesim Parman (2) Erdem Tuzun (5) - Feza Deymeer (2) - Guher Saruhan-direskeneli (1)

Department Of Physiology, Istanbul University,istanbul Medical Faculty, Istanbul, Turkey (1) - Department Of Neurology, Istanbul University,istanbul Medical Faculty, Istanbul, Turkey (2) - Department Of Neurology, Bakirkoy Research And Training Hospital For Psychiatric And Neurological Diseases, Istanbul, Turkey (3) - Department Of Pharmacy, University Of Patras, School Of Health Sciences, Patras, Greece (4) - Institute For Experimental And Medical Research, Istanbul University, Istanbul, Turkey (5)

16 - AUGMENTED TH17 CELLS AND IL-17A ARE ASSOCIATED WITH SEVERITY OF EXPERIMENTAL AUTOIMMUNE NEURITISHongliang Zhang Neuroscience Center, Department Of Neurology, The First Hospital Of Jilin University, Changchun, China

649 – N-LINKED-GLYCOSYLATION IS CRITICAL FOR DIFFERENTIATION AND FUNCTION OF INDUCED REGULATORY T CELLS. Johannes Mörike, Aleksandar Madjovski, Maria-Eloisa Mierswa-Silva, Evelyn Dubois and Felix BischofCenter of Neurology, Hertie-Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany

COFFEE BREAK & POSTER SESSION | THERAPIES 15:15 - 16:45 POSTERHALL (RHEINFOYER)

43 - ENHANCED MYELINATION IN AUTOIMMUNITY AND IN NORMAL DEVELOPMENT INDUCED BY IMMUNOMODULATORY TREATMENTRina Aharoni - Raya Eilam - Renana From - Dekel D Bar Lev - Michael Sela - Ruth Arnon The Weizmann Institute Of Science, University, Rehovot, Israel

332 - KREBS CYCLE POTENTIATION HAS IMMUNOSUPPRESSIVE EFFECTS AND INHIBITS EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS DEVELOPMENTStefano Angiari (1) - Simona L. Budui (1) - Simone D. Bach (1) - Barbara Rossi (1) - Elena Zenaro (1) - Enrica Pietronigro (1) Vittorina Della Bianca (1) - Silvia Dusi (1) - Gennj Piacentino (1) - Tommaso Carlucci (1) - Carlo Laudanna (2) Gabriela Constantin (1)

Department Of Pathology And Diagnostics, University Of Verona, Verona, Italy (1) - The Center For Biomedical Computing (cbmc), University Of Verona, Verona, Italy (2)

609 - CONTROL OF AUTOIMMUNE NEUROINFLAMMATION BY NANOPARTICLE-BASED MYELIN-ANTIGEN DELIVERY TO LIVER SINUSOIDAL ENDOTHELIAL CELLSAntonella Carambia (1) - Barbara Freund (2) - Dorothee Schwinge (1) - Oliver T. Bruns (3) - Sunhild C. Salmen (4) - Harald Ittrich (5) - Rudolph Reimer (6) - Markus Heine (2) - Samuel Huber (1) - Christian Waurisch (7) - Alexander Eychmüller (7) David C. Wraith (8) - Thomas Korn (9) - Peter Nielsen (2) - Horst Weller (4) - Christoph Schramm (1) - Stefan Lüth (1) Ansgar W. Lohse (1) - Joerg Heeren (2) - Johannes Herkel (1)

Department Of Medicine I, University Medical Centre Hamburg-eppendorf, Hamburg, Germany (1) - Department Of Biochemistry And Molecular Cell Biology, University Medical Centre Hamburg-eppendorf, Hamburg, Germany (2) - Department Of Chemistry, Massachusetts Institute Of Technology, Cambridge, Ma 02139, United States (3) - Institute Of Physical Chemistry, University Of Hamburg, Hamburg, Germany (4) - Department Of Diagnostic And Interventional Radiology, University Medical Centre Hamburg-eppendorf, Hamburg, Germany (5) - Department Of Electron Microscopy And Micro Technology, Heinrich-pette Institute, Hamburg, Germany (6) - Physical Chemistry, Tu Dresden, Dresden, Germany (7) - Cellular And Molecular Medicine, University Of Bristol, Bristol, United Kingdom (8) - Department Of Neurology, Tu München, Munich, Germany (9)

168 - IL-27 AND IL-35 AS GENE THERAPY OF NEUROINFLAMMATIONGiacomo Casella - Annamaria Finardi - Roberto Furlan Istituto Scientifico San Raffaele, Università Vita E Salute San Raffaele, Milano, Italy

598 - FLAVANOL (-)-EPICATECHIN PROTECTS AGAINST HEMORRHAGIC STROKE BY MODULATING NF-E2-RELATED FACTOR 2-DEPENDENT AND -INDEPENDENT PATHWAYSChe-feng Chang - Suzy Cho - Jian Wang Department Of Anesthesiology And Critical Care Medicine, The Johns Hopkins University School Of Medicine, Baltimore, United States



39 - TREATING MULTIPLE SCLEROSIS AND CEREBRAL PALSY WITH CHOROQUINEColin Crawford (1) - Peter Hardwicke (2)

Retired, Imperial College, London, United Kingdom (1) - Department Of Biochemistry And Molecular Biology, Southern Illinois Medical School, Carbondale, United States (2)

603 - EXPERIENCE OF SWITCHING FROM IVIG TO “MANUAL PUSH” SCIG IN 6 PATIENTS WITH CIDPMichael Cumberbatch - Amanda Cox Department Of Neurology, Addenbrooke’s Hospital, Cambridge, United Kingdom

417 - CORRELATION OF FINGOLIMOD INDUCED LYMPHOPENIA AND PHYSICAL MEASURES IN MS PATIENTSThomas Dehmel (1) - Clemens Warnke (1) - Ryan Ramanujam (2) - Kathleen Wolffram (1) - Verena I. Leussink (1) Hans-peter Hartung (1) - Bernd C. Kieseier (1)

Department Of Neurology, Heinrich-heine-university, Düsseldorf, Germany (1) - Department Of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden (2)

73 - FUMARATE TREATMENT IN PATIENTS WITH PROGRESSIVE FORMS OF MS:FIRST RESULTS OF A SINGLE-CENTER OBSERVATIONAL STUDY.Gisa Ellrichmann - Katrin Straßburger-krogias - Christos Krogias - Ralf Gold Dept Of Neurology, St. Josef Hospital / Ruhr-university Bochum, Bochum, Germany

74 - LAQUINIMOD TREATMENT IN A MOUSE MODEL OF HUNTINGTONS’S DISEASE: A NEW NEUROPROTECTIVE THERAPY?Gisa Ellrichmann (1) - Christiane Reick (2) - Carsten Saft (1) - Jan Thöne (3) - Liat Hayardeny (4) - Ralf Gold (1)

Dept Of Neurology, St. Josef Hospital / Ruhr-university Bochum, Bochum, Germany (1) - Center Of Clinical Research, Ruhr-university Bochum, Bochum, Germany (2) - Dept Of Neurology, Universitätsklinikum Essen / University Of Duisburg-essen, Essen, Germany (3) Tevapharm, Tel Aviv University, Tel Aviv, Israel (4)

567 - GENETIC ENGINEERING OF A TNFR2 AGONIST TO PROMOTE IMMUNEMODULATION AND NEUROPROTECTIONRoman Fischer - Maelle Duffey - Nathalie Peters - Oliver Seifert - Olaf Maier - Roland Kontermann - Klaus PfizenmaierInstitute Of Cell Biology And Immunology, University Stuttgart, Stuttgart, Germany

439 - DO NK CELLS PLAY A ROLE IN THE POSSIBLE ASSOCIATION BETWEEN NATALIZUMAB TREATMENT AND THE DEVELOPMENT OF MELANOMA?Ilaria Gandoglia (1) - Alice Laroni (1) - Paolo Carrega (2) - Nicole Kerlero De Rosbo (1) - Eric Armentani (1) Federico Ivaldi (1) - Giovanni Luigi Mancardi (1) - Guido Ferlazzo (3) - Antonio Uccelli (1)

Department Of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal And Child Health, University Of Genoa, Genoa, Italy (1) - Laboratory Of Clinical And Experimental Immunology, Giannina Gaslini Institute, Genoa, Italy (2) - Laboratory Of Immunology And Biotherapy, Department Of Human Pathology, University Of Messina, Messina, Italy (3)

312 - THIOPALMITOYLATED ALTERED PEPTIDE LIGANDS CAN SUCCESSFULLY TREAT ESTABLISHED DISEASE IN AN ANIMAL MODEL OF MULTIPLE SCLEROSISNancy Cloake (1) - Elisabeth Trifilieff (2) - Judith Greer (1)

Uq Centre For Clinical Research, The University Of Queensland, Brisbane, Australia (1) - Laboratoire D’imagerie Et De Neurosciences Cognitives, Universite De Strasbourg/cnrs, Strasbourg, France (2)

343 - SELECTIVE MANIPULATION OF THE CD28 CO-STIMULATION PATHWAY PREVENTS EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS INDUCTION IN THE RHESUS MONKEYKrista Haanstra (1) - Karin Dijkman (1) - Nikki Van Driel (1) - Noun Bashir (1) - Jan Bauer (2) - Bert ‘t Hart (1) - Bernard Vanhove (3)

Department Immunobiology, Biomedical Primate Research Centre, Rijswijk, Netherlands (1) - Center For Brain Research, Medical University Of Vienna, Vienna, Austria (2) - Umr-s 1064, Institut National De La Santé Et De La Recherche Médicinale, Nantes, France (3)

350 - ENHANCED IN VIVO EFFICACY OF A LONG-LIFE TYPE I INTERFERON SUPERAGONIST IN A MOUSE MODEL OF MULTIPLE SCLEROSISDaniel Harari (1) - Nadine Kallweit (2) - Renne Abramovich (1) - Keren Sasson (1) - Alla Zozulya (3) - Paul Smith (3) - Martin Schlapschy (2) - Rina Aharoni (1) - Mario Köster (4) - Raya Eliam (1) - Arne Skerra (2) - Gideon Schreiber (1)

The Weizmann Institute Of Science, ---, Rehovot, Israel (1) - Munich Center For Integrated Protein Science (cips-m) & Lehrstuhl Für Biologische Chemie, Technische Universität München, Freising-weihenstephan, Germany (2) - Ms Platform, Merck-serono, --, Geneva, Switzerland (3) - Helmholtz Centre For Infection Research, Dept. Gene Regulation And Differentiation, Braunschweig, Germany (4)

83

Scientific Program

419 - EFFECT OF INTRAVENOUS IMMUNOGLOBULINS ON NATURAL KILLER CELLSMaximilian K Heininger (1) - Gerd Meyer Zu Horste (2) - Steffen Cordes (3) - Mark Stettner (1) - Anne K. Mausberg (1) Bernd C. Kieseier (1)

Department Of Neurology, Heinrich-heine-university, Duesseldorf, Germany (1) - Center For Neurologic Diseases, Brigham & Women’s Hospital, Harvard Medical School, Boston, United States (2) - Department Of Hematology Oncolology & Tumorimmunology, Charite, Berlin, Germany (3)

164 - THE DNA METHYLATION INHIBITOR DECITABINE COMPLETELY BLOCKS AUTOIMMUNE MEDIATED CNS DEMYELINATIONKristof Thewissen - Jerome Hendriks - Piet Stinissen - Helena Slaets - Niels Hellings Biomedical Research Institute, Hasselt University, Diepenbeek, Belgium

596 - THERAPEUTIC ANTIVIRAL T CELLS NONCYTOPATHICALLY CLEAR PERSISTENTLY INFECTED MICROGLIA FOLLOWING CONVERSION INTO ANTIGEN PRESENTING CELLSJasmin Herz - Dorian Mcgavern National Institutes Of Health, National Institutes Of Neurological Disorder And Stroke (ninds), Bethesda, United States

139 - NEUROPROTECTIVE EFFECTS OF A XANTHINE OXIDASE INHIBITOR IN PROGRESSIVE EAE BY AMELIORATING MITOCHONDRIAL DYSFUNCTIONJosephe Archie Honorat (1) - Makoto Kinoshita (2) - Tatsusada Okuno (1) - Kazushiro Takata (1) - Toru Koda (1) Akiko Namba (1) - Satoru Tada (2) - Takashi Shirakura (3) - Hideki Mochizuki (1) - Saburo Sakoda (4) - Yuji Nakatsuji (1)

Department Of Neurology, Osaka University Graduate School Of Medicine, Suita, Japan (1) - Department Of Neurology, Osaka General Medical Center, Osaka, Japan (2) - Pharmaceutical Development Research Laboratories, Teijin Pharma Ltd, Tokyo, Japan (3) Department Of Neurology, Toneyama National Hospital, Toyonaka, Japan (4)

333 - EFFECT OF MONOMETHYL-FUMARATE ON EXPERIMENTAL STROKEZsolt Illes (1) - Bettina H. Clausen (2) - Bente Finsen (2) - Helle H. Nielsen (3) - Louise Lundberg (2) - Kate L. Lambertsen (2)

Institute Of Clinical Research And Department Of Neurology, University Of Southern Denmark, Odense, Denmark (1) Department Of Neurobiology Research, Institute Of Molecular Medicine, University Of Southern Denmark, Odense, Denmark (2) Department Of Neurology, Odense University Hospital, Odense, Denmark (3)

346 - PROGNOSIS AND THERAPY OF MYASTHENIA GRAVIS IN CHILDREN AND ADOLESCENTS.Yun Jing - Qian Wu - Ran Li Neurology Department, Beijing Tongren Hospital, Capital Medical University, Beijing, China

167 - CONCENTRATION DEPENDENT INHIBITORY EFFECT OF A NUCLEOSIDE-BASED ANALOG, 2, 2-BIS-HYDROXYMETHYL-CYCLOPROPAVIR, AGAINST HUMAN HERPESVIRUS-6 REPLICATIONNaomi Lee - Emily Leibovitch - Steven Jacobson National Institute Of Neurological Disorders And Stroke, N/a, Bethesda, United States

545 - TESTING DIRECT NEUROPROTECTIVE EFFECTS OF CURRENT MS THERAPEUTIC COMPOUNDS WITH INTRAVITAL TWO PHOTON LASER SCANNING MICROSCOPYDirk Luchtman - Erik Ellwardt - Volker Siffrin - Frauke Zipp Johannes Gutenberg-universität Mainz, Universitätsmedizin Der Johannes Gutenberg-universität Mainz, Mainz, Germany

54 - FASUDIL AMELIORATES DISEASE PROGRESSION IN EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS, ACTING POSSIBLY THROUGH IMMUNOMODULATION EFFECTChun-yun Liu (1) - Shang-de Guo (1) - Jie-zhong Yu (1) - Yan-hua Li (1) - Hui Zhang (1) - Qing Wang (2) - Zhi Chai (2) Ling Feng (1) - Jian-jun Huang (3) - Qian-jin Feng (2) - Bao-guo Xiao (4) - Cun-gen Ma (1)

Institute Of Brain Science, Department Of Neurology, Medical School, Shanxi Datong University, Datong, China (1) - “2011” Collaborative Innovation Center/department Of Encephalopathy And National Major Clinical Department Of Ministry Of Health, Shanxi University Of Traditional Chinese Medicine, Taiyuan, China (2) - Department Of Neurosurgery, First Hospital, Datong Coalmine Group, Datong, China (3) - Institute Of Neurology, Huashan Hospital, Institutes Of Brain Science And State Key Laboratory Of Medical Neurobiology, Fudan University, Shanghai, China (4)



187 - EFFECT OF ETHYL PYRUVATE ON CENTRAL NERVOUS SYSTEM INFLAMMATIONDjordje Miljkovic (1) - Filip Petkovic (1) - Jana Blazevski (1) - Miljana Momcilovic (1) - Neda Djedovic (1) Marija Mostarica Stojkovic (2) - Ivan Spasojevic (3)

Institute For Biological Research “sinisa Stankovic”, University Of Belgrade, Belgrade, Serbia (1) - Institute Of Microbiology And Immunology, School Of Medicine, University Of Belgrade, Belgrade, Serbia (2) - Life Sciences Department, Institute For Multidisciplinary Research, University Of Belgrade, Belgrade, Serbia (3)

632 - MENTAL HEALTH PROBLEMS TREATED WITH MEDICINAL PLANTS BY THE KHYANG OF CHITTAGONG HILL TRACTS WITHIN BANGLADESH: FROM BENCH TO BEDSIDEMd. Ariful Haque Mollik Peoples Integrated Alliance, University Of Development Alternative, Bogra, Bangladesh

468 - DIMETHYL FUMARATE ALTERS MICROGLIA PHENOTYPE AND PROTECTS NEURONS AGAINST PROINFLAMMATORY TOXIC MICROENVIRONMENTSHaiyan Peng - Maria Matos - Brian T. Wipke - Moore H. Arnold - Robert H. Scannevin Neurology Research, Biogen Idec, Cambridge, Ma

170 - TREATMENT OF IBM WITH ALEMTUZUMAB: MOLECULAR TREATMENT EFFECTS IN SKELETALMUSCLEKarsten Schmidt (1) - Konstanze Kleinschnitz (2) - Goran Rakocevic (3) - Marinos C. Dalakas (4) - Jens Schmidt (2)

Clinic For Neurology, University Medical Centre, Göttingen, Germany (1) - Department Of Neuroimmunology, Institute For Multiple Sclerosis Research And Hertie Foundation, University Medical Centre, Göttingen, Germany (2) - Department Of Neurology, Jefferson Hospital, Philadelphia, United States (3) - Neuroimmunology Unit, Department Of Pathophysiology, University Of Athens Medical School, Athen, Greece (4)

512 - THERAPEUTIC IMPLICATIONS OF APOLIPOPROTEIN E GENOTYPE IN AUTOIMMUNE INFLAMMATORY DISEASES OF THE CENTRAL NERVOUS SYSTEMLisa Schrewe - Ralf Gold - Andrew Chan Dept. Neurology, St. Josef-hospital, Ruhr-university, Bochum, Germany

377 - CELL-INTRINSIC ESTROGEN RECEPTOR ALPHA ACTIVATION IN FOXP3NEG CD4+ T CELLS CONTROLS TH1/TH17 DIFFERENTIATION IN TRANS AND PROTECTS FROM CNS AUTOIMMUNITYLaffont Sophie - Garnier Laure - Rouquié Nelly - Guéry Jean-charles Centre De Physiopathologie De Toulouse-purpan, Inserm U1043, Cnrs U5282, University Of Toulouse, Toulouse, France

461 - TREATMENT WITH ATX-MS-1467 AMELIORATES PATHOLOGICAL CHANGES AND INHIBITS CYTOKINE PRODUCTION IN MOUSE MODEL OF MULTIPLE SCLEROSISAdriano L.s. Souza (1) - Stefan Rudin (1) - Keith Mitchell (1) - Rui Chang (1) - Danielle Graham (1) - Shuning Huang (1) - Ji-kyung Choi (2) - Dongzi Yu (1) - Bruce Jenkins (2) - Joseph Mandeville (2) - Guangping Dai (2) - Mike Webb (3) - Blake Tomkinson (1) - Tammy Dellovade (1)

Neurology Etip, Translational & Biomarker Research Group, Emd Serono Research And Development Institute, Inc., Billerica, United States (1) - Athinoula A. Martinos Center For Biomedical Imaging, Massachusetts General Hospital, Charlestown, United States (2) Neurology Etip, Neuroimmunology Group, Emd Serono Research And Development Institute, Inc., Billerica, United States (3)

410 - NATALIZUMAB NEUTRALISING ANTIBODIES CAN MIMICK A PML IN MS PATIENTS - REVIEW OF 4 CASESWanet Thomas (1) - Capron Brigitte (1) - Urbain Etienne (2) - Jacquemotte Nancy (3) - Seeldrayers Pierrette (1)

Chu Charleroi, Chu Charleroi, Charleroi, Belgium (1) - Grand Hopital De Charleroi, Grand Hopital De Charleroi, Charleroi, Belgium (2) Centre De Santé Des Fagnes Chimay, Centre De Santé Des Fagnes Chimay, Chimay, Belgium (3)

497 - SHORT TERM FINGOLIMOD TREATMENT DECREASES SOLUBLE VLA 4 LEVELS IN MS PATIENTSErdem Tuzun (1) - Canan Aysel Ulusoy (1) - Selin Turan (1) - Arda Orcen (1) - Berrak Yetimler (1) - Deniz Akbas-demir (2) Melike Kucukerden (1) - Hazal Haytural (1) - Recai Turkoglu (2)

Institute For Experimental Medicine, Istanbul University, Istanbul, Turkey (1) - Haydarpasa Medical Faculty, Haydarpasa Hospital, Istanbul, Turkey (2)

85

Scientific Program

126 - INHIBITION OF RELAPSING EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS IN BIOZZI ABH MICE USING A MOUSE CD52-SPECIFIC MONOCLONAL ANTIBODYStephanie Von Kutzleben (1) - Gareth Pryce (1) - Nathalie Chretien (2) - Michael Turner (2) - William Siders (2) David Baker (1)

Insitute Of Cellular And Molecular Sciences, Queen Mary University Of London, London, United Kingdom (1) - Genzyme Corporation, Framingham, Massachusetts, United States (2)

HIGHLIGHT IN NEUROIMMUNOLOGY - GENETICS IN MS 16:45 - 17:30 PLENARY ROOM (KONGRESS SAAL)

Chair: Trevor Owens

16:45 THE GENETIC ANALYSIS OF MULTIPLE SCLEROSIS Alastair Compston

86 Day 5 | Thursday - November 13th


NEW DEVELOPMENTS IN AUTOIMMUNITY 08:15 - 09:30 PLENARY ROOM (KONGRESS SAAL)

Chairs: V Wee Yong, Jack Antel

08:15 THE AUTOIMMUNOME: AN INTEGRATED VIEW OF GENETIC SUSCEPTIBILITY STUDIES Sergio Baranzini

08:40 TRANSLATIONAL EPIDEMIOLOGY - NOVEL OPPURTUNITIES IN NEUROIMMUNOLOGY Jan Hillert

09:05 ON THE ORIGIN OF AUTOANTIBODIES Antonio Lanzavecchia


NEUROBIOLOGY IN NEUROIMMUNE DISEASES 10:00 - 11:45 ROOM A (KONGRESS SAAL)

Chairs: Antonio Uccelli, Michal Schwartz

10:00 ION AT THE BRAIN’S CHOROID PLEXUS A NOVEL NEGATIVE PLAYER IN BRAIN AGEING AND NEURODEGENERATIVE DISEASES Michal Schwartz

10:23 NEUROGENESIS OR NOT NEUROGENESIS: THIS IS THE QUESTION Gianvito Martino

10:45 REMYELINATION IN THE CENTRAL NERVOUS SYSTEM: A ROLE FOR IMMUNE CUES? Catherine Lubetzki 11:08 IMMUNE-INHIBITORY MECHANISMS TO PREVENT NEURAL DAMAGE Heinz Wiendl

11:30 465 - CNS-TARGETED IL-6 PRODUCTION LEADS TO HIGHER RECRUITMENT OF PRO-INFLAMMATORY T-HELPER CELLS AFTER FACIAL NERVE AXOTOMY Nàdia Villacampa (1) - Beatriz Almolda (1) - Iain Camobell (2) - Berta González (1) Bernardo Castellano (1) Department Of Cell Biology, Physiology And Immunology, Institute Of Neurosciences, Universitat Autònoma De Barcelona, Bellaterra, Spain (1) - School Of Molecular Bioscience, University Of Sydney, Sydney, Australia (2)

ANTIBODIES IN NEUROLOGIC AUTOIMMUNE DISORDERS 10:00 - 11:45 ROOM B (GUTENBERGSAAL 1)

Chairs: Edgar Meinl, Angela Vincent

10:00 IL-6 DEPENDENT PLASMABLASTS SECRETING AUTOANTIBODIES IN THE PATHOGENESIS OF NEUROMYELITIS OPTICA Takashi Yamamura

DAY 5 Thursday | November 13th 2014

87

Scientific Program

10:23 THE ROLE OF INFLAMMATION IN EPILEPSY: NEW THERAPAUTIC PERSPECTIVES Annamaria Vezzani 10:45 TO LOOK FOR A NEEDLE IN A HAYSTACK: AUTOANTIBODIES IN MULITPLE SCLEROSE Bernhard Hemmer 11:08 ANTI-GLYCOLIPID ANTIBODIES IN AUTOIMMUNE NEUROPATHIES: CLINICAL AND PATHOPYSHIOLOGICAL STUDIES Hugh Willison

11:30 426 - B CELL ANTIGEN PRESENTATION IS SUFFICIENT TO DRIVE NEURO-INFLAMMATION IN AN ANIMAL MODEL OF MULTIPLE SCLEROSIS Chelsea Parker (1) - Angela Archambault (1) - Julia Sim (1) - Stephen Ferris (1) - Pandelakis Koni (2) Christopher Linington (3) - John Russell (1) - Gregory Wu (1) Washington University In St. Louis, Washington University In St. Louis, St. Louis, United States (1) - Cancer Immunology, Inflammation And Tolerance Program, Cancer Center And Department Of Medicine, Georgia Regents University, Augusta, United States (2) - University Of Glasgow, University Of Glasgow, Glasgow, United Kingdom (3)

TREATMENTS - PROS AND CONS (ACTRIMS) 10:00 - 11:45 ROOM C (GUTENBERGSAAL 2)

Chair: Bernd C. Kieseier

10:00 Hans Peter Hartung 10:21 Ludwig Kappos

10:42 NOVEL TREATMENTS FROM THE PERSPECTIVE OF ANTI-INFLAMMATORY AND NEUROPROTECTIVE EFFECTS Frauke Zipp

11:03 BIOMARKERS: WHAT HAVE WE LEARNED FROM TREATMENTS - ACTRIMS Suhayl Dhib-Jalbut

11:24 EMERGING INSIGHTS INTO B CELL: T CELL: MYELOID INTERATIONS AND IMPLICATION TO THERAPEUTIC TARGETS IN CNS INFLAMMATION Amit Bar-Or

LUNCH BREAK 12:00 - 13:00 POSTERHALL (RHEINFOYER)

THE MONTALCINI LECTURE 13:00 - 13:45 PLENARY ROOM (KONGRESS SAAL)

Chairs: Alastair Compston,

13:00 OLIGODENDRYOCYTES AND THE PROTECTION OF AXONAL INTEGRETY IN MYELIN DISEASE Klaus-Armin Nave

CLOSING 13:45 - 15:15 PLENARY ROOM (KONGRESS SAAL)

89

Scientific Program

Author Index

Ali Sepehry Amir 65

A Andrade Ulisses 34

A Buurman Wim 69

A Glicksman Marcie 46

A Newman Newman Tracey 47

A Panzara Michael 42

A Warren Edward 16

A. Asuni Ayodeji. 50

A. Campbell Veronica 72

A. Friese Manuel 26, 68

A. Harris Robert 45

A. Honorat Josephe 25

A. Kato Takahiro 32

A. Kruse Torben 52

A. Laurent Sarah 42

A. Lynch Marina 55

A. Lynch Marina. 62

A. Pardo Luis 67

A. Riester Katherine 77

A. Rogers James 58

A. Sobel Raymond 80

A. Winer Daniel 47

Abadier Michael 23

Abe Masaaki 24

Abrahamsen Greger 43

Abramovich Renne 82

Abuneeza Esadawi 47

Abutbul Shai 71

Acharjee Shaona 14

Achour Adnane 45

Acosta Crystal 53

Acuña Eric 70

Adem Abdu 80

Adzemovic Milena 24

Aeinehband Shahin 47

Ag Ricigliano Vito 46, 66

Aguilar Esther 17, 32

Aharoni Rina 67, 81, 82

Ahrends Hannah 63

Ai Youxi 31

Aid Saba 71

Airas Laura 46

Akkoc Tunc 76

Akrivou Sofia 40

Aktas Orhan 20, 56

Alastair S Compston D 42

Alba Merce 17

Albayram Önder 63

Alcamí Antonio 49

Alexopoulos Haris 40

Alexopoulos Harry 17

Alferink Judith 56, 57, 63

Alifirova Valentina 73

Allaire Norm 28

Allie Nasiema 66

Alloza Iraide 45

Almolda Beatriz 14, 30, 56, 86

Alpi Emanuele 75

Altevogt Peter 36

Altintas Ayse 20, 67

Alvarez Jorge 22

Amadio Stefano 51

Amar Majid 72

Amatruda Mario 48

Amiable Nathalie 44

Aminian Atefeh 16

Amit Ido 55, 61

Ammitzboell Cecilie 45

Amor Sandra 15, 30

Amoruso Antonella 24, 44

Anastasiadou Eleni 66

Andreetta Francesca 22, 71

Angiari Stefano 63, 74, 81

Annese Anita 16, 66

Annibali Viviana 16, 40, 46, 66

Antel Jack 15, 22, 29, 55, 58

Antigüedad Alfredo 45

Antonio Gerardo Ricigliano Vito 16

Aoki Masashi 70

Aranami Toshimasa 79

Arbour Nathalie 22, 38, 43, 58

Archambault Angela 87

Archie Honorat Josephe 21, 83

Ariful Haque Mollik Md. 34, 84

Ariño Helena 17

Arip Masita 25

Armentani Eric 40, 82

Arnold Bernd 36, 72

Arnold Douglas 63

Arnon Ruth 67, 81

Arsenijevic Aleksandar 19, 67

Arsenijevic Nebojsa 19, 67

Arslan Sevki 48, 57

Arthur Ariel 70

Arunachalam Priyadharshini 48, 68

Ase Ariel 29

Asgari Nasrin 40

Astarita Jillian 43

Astobiza Ianire 45

Aubé Benoît 51

Aucouturier Pierre 71

Augusto Feitosa Pereira Alvaro 49

Avidan Nili 43

Avolio Carlo 37, 40

Axel Laplaud David 77

Axtell Robert 33

Aysal Fikret 81

Aysel Ulusoy Canan 76, 84

Ayta Semih 80

B Chibnik Lori 46

B F Rutten Bart 69

B Nutman Thomas 16

B. Keough Michael 58, 74

Babcock Alicia 53

Bach Soendergaard Helle 45

Bachi Angela 75

Bacigaluppi Marco 23, 74

Baehr Mathias 72

Baekelandt Veerle 53

Baggi Fulvio 71

Baggiolini Arianna 73

Baguhl Romy 48

Bahtz Ramona 18, 64

Bai Jing 27

Bajramovic Jeffrey 27, 28

Baker David 85

Bakhshandepour Gholamreza 26

Baksmeier Christine 41

Balboni Gianfranco 47

90 AUTHOR INDEX


Balcarek Peter 44

Balint Bettina 21

Balzarolo Melania 48

Balzarotti Beatrice 75

Bando Yoshio 33

Bankhead Peter 73, 77, 78

Banwell Brenda 29, 63

Baranuskas Gytis 71

Baranzini Sergio 33, 47, 85

Barat Corine 23

Barbieri Francesca 79

Barcellos Lisa 45

Barger Zeke 14

Barington Torben 20

Baris Safa 80

Barnum Chris 38

Baron Rona 44

Bar-Or Amit 59, 87

Barrera Iliana 14

Bartholomäus Ingo 61

Bartos Ales 18

Baruch Kuti 61

Baser Hatice 19

Bashinskaya Vitalina 20, 21

Bashir Noun 82

Basnyat Pabitra 21

Bataller Luis 39

Battistini Luca 11, 16, 35, 40, 79

Bauer Jan 71, 82

Bauer Jens 56

Baulina Natalia 21

Baumann Bernd 54

Bazzoli Elena 64, 65, 74

Beauseigle Diane 43, 58

Becher Burkhard 15, 27, 28, 48, 73, 78

Becher Juliane 48

Bechmann Ingo 15, 60

Becker Simon 42

Bedell Barry 15

Bedford Lynn 68

Bee Eow Gaik 25

Begemann Nora 21, 64

Behrens Janina 28

Bekner Freja 45

Belabani Chahrazed 29

Belikan Patrick 49, 76

Benabdellah Karim 76

Bendix Ivo 31

Bendotti Caterina 51

Benhar Inbal 40

Bennett Jeffrey 17, 63, 64

Berer Kerstin 67

Berera Giulia 37

Berg Johannes 41, 46

Bergamaschi Andrea 57

Berge Tone 43, 45

Berger Thomas 19

Berglund Rasmus 48, 78

Bergman Petra 46, 47, 48

Bergmann Cornelia 17, 67

Berki Timea 20, 69

Berkutzki Tamara 61

Berl Sabina 48

Berl Stefan 40

Berlin Roseann 17

Bernard Isabelle 42

Bernard Lakes Yenal 75

Bernardes Danielle 68

Bernasconi Pia 71

Berndt Dominique 70

Bernreuther Christian 68

Berthele Achim 20

Bertolotto Antonio 20, 48

Bethea John 31, 68

Bezalel Dana 61

Bhatia Urvashi 38, 52

Bhonsle Latika 77

Bianchi Veronica 51

Biberacher Viola 77

Biffi Emilia 51

Bilkova Zuzana 18

Bin Jenea 22

Bing Chow Han 25

Birkenstock Jérôme 76

Birkner Katharina 62, 80

Bishay Philipp 57

Bistaffa Edoardo 65

Biswas Aindrila 65

Biton Shva 44

Bittner Stefan 38, 47, 57, 68, 77, 78

Bjølgerud Anja 43, 45

Blaabjerg Morten 48

Blanchfield Lori 76

Blatti Claudia 23, 24

Blauth Kevin 17

Blazevski Jana 84

Blezer Erwin 41

Bliederhäuser Corinna 30

Blierderhaeuser Corinna 28

Bloemker Dominique 65

Blonda Maria 40

Blorea Bogdan 18

Blumenfeld Shiri 37

Böhme Anne 49

Bojcevski Jovana 71

Boldrin Valentina 51

Bollman Bryan 70

Bommhardt Ursula 78

Bonetti Bruno 50, 64, 65, 74

Böning Daniel 23

Bonnin Alexandre 18

Boodhoo Dallas 57

Bopp Tobias 56, 62

Borisov Alexei 45

Borisow Nadja 28

Börnsen Lars 45

Borowski Kathrin 18, 21

Borsellino Giovanna 79

Boscacci Rémy 23, 24

Bösche Katharina 33, 34

Boschert Ursula 27

Bosoi Ciprian 32

Bourbonniere Lyne 22, 36

Bourbonnière Lyne 23, 32, 52, 64

Bowie Andrew 27

Boyko Alexey 20, 21

Boyko Anastasia 73

Bozoyan Lusine 73

Bp Rutten Bart 69

Bradl Monika 71

Bradshaw Elizabeth 27

Bragoni Alberto 56

Braiotta Gino 20

Brambilla Elena 60, 74, 75

Brambilla Roberta 68

Branton William 55

Brassat David 35

Braun Jürgen 70

91

Scientific Program

Breit Samuel 16

Brenner Talma 17

Breuer Johanna 22, 23, 38

Breur Marjolein 30

Brgamaschi Andrea 51

Briggs Farren 45

Brigitte Capron 84

Brilha Sara 37

Brimberg Lior 17, 18

Bros Elena 71

Broux Bieke 36, 49

Brown David 16

Brown Joe 63

Brück Wolfgang 12, 18, 24, 30, 32, 37

67, 78

Brücke Thomas 18

Brueck Wolfgang 73

Bruinsma Ilona 33, 47

Brun Susana 31

Brunetto Giovanna 65, 66

Brüning Jens 15

Bry Lynn 54

Bsibsi Malika 15

Buch Thorsten 15, 73

Buck Dorothea 22, 77

Budde Thomas 55, 68, 77

Budoo Nishta 79

Buehler Ulrike 76

Bufe Bernd 30

Buffo Annalisa 76

Bühler Ulrike 49, 52

Bülow Mie 25

Bunning Rowena 47

Bunse Lukas 64, 65

Burgoon Mark 20

Burm Saskia 27

Burman Joachim 49

Burns Evans 29

Bürth Christoph 43

Butovsky Oleg 29, 38, 54

Buttgereit Anne 27

Butti Erica 37, 74

Bytko Xenia 46

C Anthony Daniel 16, 39

C Beck Hans 15

C Dodge James 42

C Evans Matthew 39

C Fitzgerald Denise 78

C Kieseier Bernd 44

C Ramsperger Vincent 69

C. Bernard Claude 18

C. Bullard Daniel 23

C. Dalakas Marinos 44, 84

C. Fitzgerald Denise 77

C. Gross Catharina 52

C. Kieseier Bernd 43, 73, 82, 83, 87

C. Kurschus Florian 69, 80

C. Ludolph Albert 28, 30

C. Rosenkranz Sina 26

C. Salmen Sunhild 81

C. Schmitt Patricia 14

C. Wraith David 81

Caballero Eva 17

Cagnard Nicolas 71

Calabria Francesca 64

Calçada Daniela 34

Caldano Marzia 48

Calle Vanessa 71

Camobell Iain 86

Campbell Iain 30, 71

Campbell Ian 56

Campbell Sandra 16

Canales Mathieu 29

Cantoni Claudia 15, 70

Capi Matilde 40

Capitolo Eleonora 50

Caputo Domenico 19, 28

Carambia Antonella 81

Cárcamo Claudia 70

Carlström Karl 71

Carlucci Tommaso 81

Carmant Lionel 32

Carrega Paolo 82

Caruso Breanna 66

Carvajal Alexander 17

Casazza Simona 51

Casella Giacomo 81

Casiraghi Costanza 41

Casola Stefano 80

Castellano Bernardo 14, 30, 56, 86

Castilló Joaquín 20

Castro Poppe Sandra 49

Cattane Nadia 64

Cavaliere Chiara 75

Cavanagh Jonathan 55

Cavazzi Elena 55

Cayrol Romain 38

Cecconi Francesco 48

Cecile Delarasse 72

Cédile Oriane 76

Celik Gurbet 57

Centonze Diego 56, 74, 79

Cerina Manuela 68

Ceuppens Jan 80

Chaabane Linda 37, 50, 51

Chai Zhi 50, 83

Chaigneau Thomas 71

Chalmin Fanny 56, 79

Chalmoukou Konstantina 40

Champigny Camille 58

Chan Andrew 49, 84

Chan Gail 27, 46, 50

Chang Rui 84

Chapman Joab 31

Chapple Katie 70

Charabati Marc 38, 50

Chavakis Triantafyllos 38

Checa Begona 16

Chegini Leila 26

Cheng Fan 66

Chiara Buscarinu Maria 16, 40, 66

Chiba Asako 69

Chiba Atsuro 25, 26

Chihara Norio 79

Chisholm Jesse 54

Cho Suzy 81

Choi Elliot 70

Chretien Nathalie 31, 85

Christiansen Josefine 79

Christin Starossom Sarah 58

Chudyka Daria 23

Cialic Cialic Ron 38

Cimpean Maria 27, 46

Ciric Bogoljub 39

Ciriello Giovanni 64

Ciuta Cecile 32

Clausen Björn 38

Clemente Diego 27, 29

92 AUTHOR INDEX


Clerici Mario 19, 28

Cloake Nancy 16, 82

Clover Linda 17

Cm Hoogland Inge 59

Coarelli Giulia 66

Cohen Merav 55, 56

Cokar Ozlem 80

Colacios Céline 42

Coll Rebecca 51

Collins Hayden 59, 67

Colombo Emanuela 40, 50

Colombo Federico 50

Comabella Manuel 20, 45

Comi Giancarlo 23, 37, 40, 46, 51, 57

74, 75

Compta Yaroslau 39

Congiu Cenzo 47

Connolly Mary 32

Connor Thomas 33, 56

Consortium Anzgene 46

Constantin Gabriela 24, 41, 44, 50, 63

74, 81

Constantinescu Cris 68

Contreras Angeles 39

Cooper Matthew 51

Cooper Susan 66

Coppola Giovanni 78

Cordano Christian 56

Cordes Maike 43

Cordes Steffen 83

Cordiglieri Chiara 71

Cortes Claudia 53

Cossetti Chiara 75

Costa Patrício 78

Costa Riu Carme 20

Costanza Massimo 47, 50

Côté Mélissa 51

Couch Yvonne 16, 39, 57

Cox Amanda 82

Cox Donal 27

Crapser Josh 79

Crapser Joshua 68

Crawford Colin 82

Crisp Sarah 68

Cristina Ortega María 27

Crook Kenneth 27

Crooks James 68

Cross Alison 47

Cross Anne 15, 70

Csepany Tunde 69

Cudna Agnes 23

Cudrici Cornelia 57

Cugurra Andrea 57

Cullen Patrick 28

Cumberbatch Michael 82

Curley Tara 59

Cusick Matthew 68

Cusimano Melania 60

D Andersen Beatrice 30

D Bos Steffan 45

D Boyd Justin 46

D Palmer Theo 54

D. Bach Simone 81

D. Bos Steffan 43

D. Dijkstra Chriistine 28

D. Fontenot Jason 28, 77

D. Hammond Matthew 31

D. Laman Jon 44

D. Miller Stephen 37

D. Ponomarev Eugene 58

Dai Guangping 84

Dalakas Marinos 17, 40

Daldrup Theimo 55

Dalko Esther 66

Dalmau Josep 17, 19, 32, 39

Damoiseaux Jan 19

Damotte Vincent 13

Dams Maria 36

Daniel Gerhard 18

Daniels Brian 23

Danoff Jacob 57

Danquah Welbeck 43

Dansokho Cira 71

Dantzer Robert 12, 51

Danzer Karin 30

Darin Niklas 12

Darko Sam 76

Darlington Peter 22

Dastidar Prasun 21

David Eyal 55, 61

David Yaron 71

Davis Matthew 75

Davis Mollie 20

Day Jennifer 56

De Fátima Monteiro Martins Maria 49

De Paula Coelho Cideli 49

Deblois Gabrielle 43

Debradant Birgit 25

Debruin Natasja 33, 57

Deczkowska Aleksandra 61

Degn Matilda 17, 22, 30

Dehmel Thomas 16, 44, 82

Deisenhammer Florian 19

Dejana Elisabetta 24

Dejean Anne 42

Delarasse Cecile 55

Delatour Benoit 72

Deligoz Hasalettin 48

Dellarole Anna 68

Dellovade Tammy 84

Delogu Giovanni 41

Delorenzi Mauro 29

Demir Seray 41

Demirbilek Veysi 80

Dempsey Colin 51

Deniz Günnur 20

Dennison Kathryn 59

Denno Yvonne 21, 64

Dental Clelia 23

Depboylu Candan 36

Derksen Angelika 44, 73

Derle Eda 53

Dervenoulas Georgios 64

Deutsch Urban 23, 24

Devraij Kavi 36

Deymeer Feza 81

Diamond Betty 17, 18

Didkovskiy Nikolay 66

Diem Ricarda 14, 51, 62, 71, 73

Dijkman Karin 18, 41, 82

Dijkstra Christine 30

Dina Giorgia 37

Disano Krista 17

Dittmer Marie 73, 77

Dittmer Ulf 65

Djedovic Neda 84

Doi Shizuki 29

Dolei Antonina 67

93

Scientific Program

Dombrowski Yvonne 73, 77, 78

Dombrowski, Yvonne 78

Domonova Elvira 66

Donega’ Matteo 75

Donnarumma Tiziano 63

Dooley Dearbhaile 54

Doran Sarah 68

Dorman Olga 42, 74

Dornmair Klaus 77

Dorothée Guillaume 71

Doucet Marika 72

Douek Daniel 76

Doykan Camille 38

Dræby Dina 28

Drago Denise 75

Dressel Alexander 48

Drexhage Joost 24

Dreykluft Angela 23

Dua Priya 26

Dua Priyamvada 68

Duffey Maelle 82

Dumas Aline 44, 73

Dunn Shannon 29

Dunne Aisling 27

Duquette Pierre 38, 64

Durmus Hacer 81

Durrenberger Pascal 51

Duscha Alexander 41

Dusi Silvia 24, 44, 63, 81

Dustin Irene 65

Dzharullaeva Alina 69

E. Clausen Björn 39

E. Dunn Shannon 47

E. Goings Gwen 37

E. Greenlee John 64

E. Hauser Anja 19

E. Muth Ingrid 44

E. Voll Reinhard 44

Easton Alexander 45

Eberle Max 33

Edenhofer Frank 75

Edwards Taylor 20

Efroni Sol 29

Eggen Bart 15

Ehling Petra 77

Eichinger Paul 77

Eichler Tilo 65

Eijsink Vivian 33

Eilam Raya 67, 81

Eileen Menezes Baliellas Deborah 49

Einstein Ofira 31

Eisel Uli 14

Ekmekci Ozgul 25

Elboudwarej Emon 45

Elcil Serkan 48

Eleni Pappa 56

Elger Christian 17

Eliam Raya 82

Elibol Bülent 26

Elliott Christina 70

Ellman Dite 31

Ellrichmann Gisa 33, 82

Ellwardt Erik 14, 83

Elovaara Irina 21

Elston John 66

Elyaman Wassim 15, 27

Emrich Michael 71

Engbers Annika 52

Engelhardt Britta 11, 13, 23, 24, 35

Engelhardt Mathias 80

Engler Harald 33, 34, 65

Enright Anton 75

Erba Eugenio 51

Erdag Ece 20, 41

Eriksson Ulf 24

Ernst Joachim 43

Errede Mariella 51

Eschborn Melanie 41, 52

Espejo Carmen 49

Espiño Mercedes 19

Etienne Urbain 84

Etzerodt Anders 73

Evangelakou Panagiota 22

Evavold Brian 76

Eychmüller Alexander 81

Eze Chigo 65

F Dowell Scott 16

F Harbo Hanne 45

F Kuipers Hedwich 42, 54

F Lipka Alexander 25

F. Angelini Daniela 16, 40

F. Charo Israel 24

F. Fragoso Maria 28

F. Harbo Hanne 43

F. Lichtenthaler Stefan 42

Faber Bart 18

Faber Hans 77

Fabian Michelle 21

Fagan Steven 72

Faigle Wolfgang 33

Fainberg Karin 42, 74

Fainstein Nina 31, 74

Fairless Richard 14, 51, 71, 73

Faissner Andreas 76

Fan Yan 74

Fanek Fanek Zain 38

Fanek Zain 38, 54

Farina Cinthia 28, 40, 46, 47, 50, 74

Farinazzo Alessia 64, 65, 74

Farrell Colleen 21

Favorov Alexander 21

Favorova Olga 20, 21

Fechner Kai 18, 21

Fedulov Alexander 45

Feher Gergely 25

Fehniger Todd 15

Feldmann Linda 15

Feliú Ana 49, 51, 55

Feng Jiachun 27

Feng Ling 50, 83

Fenger Christina 52

Ferger Boris 54

Ferlazzo Guido 82

Fernandes Bondan Eduardo 49

Fernandez Oscar 45

Fernando Monteiro Gimenez Caio 49

Ferrara Giovanni 51

Ferreira Filipa 34

Ferreiros Nerea 33

Ferreirós Nerea 57

Ferrigno Giancarlo 51

Ferris Stephen 87

Fiinsen Bente 53

Filali Mohammed 73

Fillatreau Simon 63

Finardi Annamaria 50, 57, 81

Fink Katarina 12

Finsen Bente 52, 83

94 AUTHOR INDEX


Firmenich Stephanie 80

Fischer Roman 14, 82

Fisher Yair 44

Fissolo Nicolas 20

Fitzgerald Denise 73

Flanagan Ken 23, 38

Fleidervish Ilya 71

Flügel Alexander 78

Flytzani Sevasti 43

Fontaine Bertrand 13, 55, 72

Fontaine François 32

Fontana Elena 47

Förster Irmgard 57, 63

Forsthuber Thomas 22

Fouka Pinelopi 17

Fournier Sylvie 62

Francisco Ngiambudulu 66

Frangieh Michael 27, 46

Frank Ida 76

Fransson Moa 49

Frauenknecht Katrin 31

Frauscher Birgit 79

Fraussen Judith 19

Frausto Ricardo 49

Frenkian Mélinée 43

Freund Barbara 81

Friedler Brett 68

Friedman Alon 71

Frigerio Federica 52

From Renana 81

Fujihara Kazuo 70

Fujii Chihiro 77

Fujiki Naoto 29

Fujinami Robert 68

Fujioka Toshiki 31

Fukazawa Toshiyuki 29

Furlan Roberto 12, 34, 40, 50, 51, 57

79, 81

G. Fehlings Michael 73

G. Meuth Sven 38, 47, 52, 57, 68, 77

78

G. Okun Jürgen 53

G. Tovey Michael 66

Gadani Sachin 78

Gadoth Avi 74

Gaig Carles 39

Galicia Georgina 17

Gallego Juan 41

Gallizioli Mattia 23

Gandhi Roopali 40

Gandoglia Ilaria 40, 82

Gardiner Chris 39

Gargano Francesca 79

Garron Carrie 31

Garzetti Livia 51

Gasperini Claudio 79

Gaud Guillaume 42

Gebauer Christina 23, 35

Geerts Dirk 13

Geisler Carsten 30

Geisslinger Gerd 31, 33, 57

Gekas Georgios 56

Gelderblom Mathias 48, 68

Gelfand Jeffrey 18

Gelpí Ellen 39

Gendron Steve 69

Gennarelli Massimo 64

George Jithin 66

Gerald Christophe 21

Gerdes Lisa 19

Gerloff Christian 68

Gerritsen Wouter 15, 30

Geschwind Daniel 78

Geschwind Michael 18

Geurts Jeroen 33, 47

Ghaffarian Nikoo 68

Ghannam Soufiane 23, 49, 52

Ghimenton Claudio 64

Gibbert Kathrin 65

Gieler Uwe 34

Ginzburg Elizabeta 43

Giometto Bruno 20, 39

Giorda Ezio 41

Giovannoni Gavin 26, 68

Giraudon Pascale 68

Girolamo Francesco 51

Gironi Maira 41

Giunti Debora 52, 56

Giusto Elena 75

Glatzel Markus 68

Gliem Micheal 56

Glumm Sarah 47

Göb Eva 68

Göbel Kerstin 38, 55, 68

Goebels Norbert 17, 41

Gokyigit Aysen 80

Gold Ralf 33, 39, 41, 46, 49, 76, 78

82, 84

Gollan Rene 52

Gollan René 49

Gomez Fabian 21

Gommerman Jennifer 43, 63, 64

Gonzalez Berta 30, 56

González Berta 14, 86

Goodkin Howard 32

Gorji Ali 68

Gorodetsky Raphael 74

Götz Alexander 67

Gouverneur Veronique 16

Gowing Elizabeth 69

Grabitz Carl 42

Graham Danielle 84

Graham Gerard 55

Gran Bruno 68, 77

Graner Michael 20, 59

Granieri Letizia 20

Grassivaro Francesca 28

Grasso Roberta 40

Graus Francesc 17, 32, 39

Grazia Grasso Maria 79

Greco David 38, 54

Greco Greco David 38

Greer Judith 16, 46, 82

Grenier Jeremy 53

Greter Melanie 11, 27, 74

Grilli Mariagrazia 68

Gros Hélène 67

Groß Catharina 38

Gross Catharina 23

Grozdanov Veselin 28, 30

Gruart Agnès 14, 38

Grummel Verena 22

Grützke Berit 16

Gu Xiaoyi 27, 59

Guaza Carmen 49, 51, 55

Gudi Viktoria 80

Guenzi Eric 14

Gul Alpaslan Bengi 67

95

Scientific Program

Gunaydin Dicle 67

Günther Robert 19

Guo Jing 70

Gurkan Gulben 76

Gürses Candan 80

Gurskaya Olga 66

Guryev Victor 46

H Han May 54

H Kasper Lloyd 42

H Margolin David 42

H. Arnold Moore 84

H. Clausen Bettina 83

H. Nielsen Helle 83

H. Plate Karl 36

H. Sansing Lauren 31

H. Scannevin Robert 56, 84

H. Tator Charles 73

H. Weishaupt Jochen 28, 30

Haanstra Krista 82

Haas Christina 41

Haberl Michael 78

Hachehouche Lamia 22, 36

Hachiya Yasuo 25

Hacibekiroglu Isil 57

Hackenbruch Christopher 62

Hadamitzky Martin 33, 34

Haddad Elie 32

Haddock Gail 47

Haeussler Annett 31

Haghikia Aiden 41, 46

Hagiwara Wataru 31

Hagman Sanna 21

Hailov Nikita 66

Hainke Undine 30

Hallböök Tove 12

Hamada Yukihiro 18

Hamann Dörte 20

Hametner Simon 71

Han May 33, 61

Handel Adam 46

Hanip Rafia Md 25

Hanja Stürner Klarissa 22

Hanwell Heather 29

Harari Daniel 82

Hardwicke Peter 82

Harkin Andrew 33, 56, 72

Harris Robert 29

Harris Tajie 66, 78

Hart Prue 16

Hartwig Tom 28, 48

Haruki Hiroyo 24

Hasan Maruf 80

Hashimoto Hitoshi 56

Hassanpour Masoud 16

Hategan Alina 16

Haugen Mette 65

Haugen Morten 17

Haupeltshofer Steffen 39

Häusler Darius 37

Häussler Annett 57

Havari Evis 42

Havrdova Eva 29, 42

Hayakari Ryo 29, 30

Hayardeny Liat 82

Hayashi Masaharu 70

Haytural Hazal 84

Healy Luke 58

Heeren Joerg 81

Heesen Christoph 22, 78

Heijmans Nicole 18

Heijnen Priscilla 28, 30

Heikema Astrid 28

Hein Katharina 72

Heine Markus 81

Heinemann Christina 14

Heink Sylvia 14

Heinrich Julia 66

Held Kathrin 77

Hellings Niels 19, 53, 83

Helminen Mika 21

Hemmer Bernhard 12, 14, 22, 69, 77

86

Hendriks Jerome 19, 53, 83

Hendrix Sven 54

Heneka Michael 61, 71

Hengerer Bastian 28

Henry Rebecca 28

Henseleit Korinna 26

Herkel Johannes 81

Herold Martin 38, 52

Herold Sabine 72

Herrmann Alexander 47, 77

Herrmann Andreas 14

Herrmann Ralf 31

Hertwig Laura 28

Herwerth Marina 69

Herz Jasmin 83

Herz Josephine 52

Hicking Gordon 68

Hidalgo Juan 14

Higgins Sarah 55

Hintzen Rogier 47

Hinz Lisa 41, 46

Hirano Makito 18

Hirano Yuta 53

Hjelm Clausen Bettina 52

Hoerauf Achim 63

Hofer Markus 14

Hoffmann Carolin 69

Hoffmann Franziska 17, 19, 42

Hofman Sam 18

Hofstetter Harald 77

Höftberger Romana 19, 20

Hoghooghi Vahid 52

Högl Birgit 79

Höglinger Günter 36

Hohendorf Tilman 23

Hohlfeld Reinhard 19, 42, 77

Hokari Mariko 42

Holm Thomas 28

Holman David 23

Holtman Inge 15

Holzenberger Martin 71

Hongyu Luo 49

Horakova Dana 29

Horn Katharina 19

Horwitz Marc 41

Hoskin David 45

Hou Xinlin 31

Hromadkova Lenka 18

Hu Yan 49

Huang Bing 75

Huang Jianhua 31

Huang Shuning 84

Huber Samuel 81

Hucke Stephanie 16, 23, 52, 54

Huehn Jochen 50

Huerta Patricio 17

96 AUTHOR INDEX


Hugh Perry V. 53

Hugues Stéphanie 56

Huizinga Ruth 28

Huppert Jula 32

Hupperts Raymond 19

Huppke Peter 39

Hvilsted Nielsen Helle 15, 20, 52

I. Leussink Verena 82

I. Rees Mark 72

Iacenda Domenica 43

Ibbett Paul 53

Ibrahim Nadeen 67

Ichikawa Motoki 53

Ifergan Igal 53

Iinuma Kyoko 46

Ikeda Ken 32, 53

Ikeda Tokuhei 26

Ikeguchi Ryotaro 79

Iking Janette 47

Ilkjær Laura 53

Illes Zsolt 15, 25, 48, 69, 83

Illés Zsolt 20

Im Gina 59

Imaizumi Tadaatsu 29, 30

Imitola Jaime 27

Inati Sara 65

Inglese Matilde 21

Ingwersen Jens 56

Inoue Masashi 31

Iori Valentina 52

Iraci Nunzio 75

Irani Sarosh 18

Iranzo Alex 39

Irla Magali 76

Isaac Sandrine 32

Isabel Leite M. 20

Isabel Leite Maria 26, 66

Ishida Chiho 26

Isobe Noriko 46

Israel Nicole 69, 78, 80

Itoyama Yasuto 70

Ittrich Harald 81

Itzhaki Zohar 61

Ivaldi Federico 40, 82

Ivan Alvarez Jorge 38, 52, 53, 64

Ivanchik Halina 45

Ivanchyk Halina 75

Ivanova Maria 69

Ivanova Svetlana 73

Iwantscheff Simeon 42

Iwasaki Yasuo 32, 53

J Coles Alasdair 42

J Fournie Gilbert 42

J Lamorte Michael 31

J Lindemann Matthew 69

J Randall Philippa 66

J Ryan Katie 46

J Turner Michael 31, 42

J. Fischer Henrike 39

J. Huss David 28, 77

J. Ingram Rebecca 73

J. Klaver Elsenoor 28

J. Lotery Andrew 53

J. Mothe Andrea 73

J. Parnham Michael 31, 33, 57

J. Priatel John 44

J. Speckmann Erwin 68

J. Titulaer Maarten 32

J. Tremblay Michel 23

Jacobs Bart 28

Jacobs Muazzam 66, 67

Jacobson Leslie 17, 68

Jacobson Steve 65

Jacobson Steven 66, 76, 83

Jagessar Anwar 18, 41

Jagodic Maja 43, 46, 47, 48, 78

Jain Anajana 31

Jain Ankit 32

Jalilzadeh Ghazal 26

Jankovicova Barbora 18

Janssen Hans 44

Janssen Lennert 44

Janssens Kris 53

Jarius Sven 20

Jarova Maria 66

Jeanne Billioux Bridgette 65

Jeganathan Venkatesh 17

Jelcic Ilijas 18, 33, 63

Jelcic Ivan 18, 63

Jenkins Bruce 84

Jennifer Ahn J. 47

Jesus Pinto Maria 45, 76

Ji Xuhuai 33, 47

Jiang Wei 58

Jin Chae Jae 44

Jin Wei 49

Jing Yun 83

Jm Franklin Robin 73

Joaquim Andreia 49

Johnson Kory 76

Johnson Tory 16

Johnson Trina 29, 63

Jones Ken 63

Jones Nicola 66

Jongen Peter 19

Jonjic Stipan 67

Jordan Holger 31

José Cerqueira João 34

Joseph Christy 48

Jozsi Mihaly 69

Jujjavarapu Harsha 23

Juknat Ana 78

Jung Steffen 61

Jungmann Lara 39

Junker Andreas 73

K Andreassen Bettina 45

K Heininger Maximilian 83

K Kuchroo Vijay 15

K Mausberg Anne 44

K Moestrup Søren 73

K Williams Sarah 71

K. Heininger Maximilian 43

K. Kuchroo Vijay 63

K. Mausberg Anne 43, 83

K. Williams Sarah 14, 51

Kachan Tatiana 45

Kaden Klara 67

Kadowaki Atsushi 69

Kakita Akiyoshi 42

Kalinke Ulrich 66

Kaliouli Christiana 56

Kallweit Nadine 82

Kanba Shigenobu 32

Kanda Takashi 24

Kanellopoulos Jean 72

Kang Chia Yuen 25

Kano Osamu 32

Kanyshkova Tatyana 77

97

Scientific Program

Kap Yolanda 18

Karamita Maria 38

Karamouzos Emmanouil 56

Karandreas Nikos 22

Karasoy Hatice 25

Karni Arnon 42, 74

Karpova Darja 36

Karram Khalad 69, 80

Karussis Dimitrios 75

Kasran Ahmad 80

Kassem Sahar 42

Kassis Kassis Ibrahim 75

Kassubek Jan 28

Kastrukoff Lorne 32

Katayama Takahiro 53

Kato Tomoko 25

Katzav Aviva 31

Kaufmann Annika 30

Kaushansky Nathali 78

Kaushik Deepak 69

Kawabe Kiyokazu 32, 53

Kawachi Izumi 42

Kawakami Naoto 61

Kawano Yuji 46

Kay Robert 43

Kazanova Galina 66

Kearney Neil 27

Kebir Hania 32, 38, 52, 53, 64

Kébir Hania 23, 36

Keeton Roanne 66

Keil Melanie 53, 58

Kellaway Lauriston 66, 67

Keller Sascha 36

Keminer Oliver 22

Kempe Karina 31

Kempf Christian 63

Kemter Andrea 63

Kennedy Timothy 22

Kersemans Veerle 16

Kertser Alexander 61

Keshari Pankaj 43

Keßler Jöran 19

Ketzef Maya 71

Khademi Mohsen 42, 48

Khazaei Mohammad 73

Khorooshi Reza 50

Kibaroglu Seda 53

Kidd Grahame 24

Kieseier Bernd 16, 77

Kikuchi Seiji 29

Kimura Kimitoshi 77

Kinner Olga 54

Kinoshita Makoto 83

Kinsara Angham 29

Kinzel Silke 18

Kipnis Jonathan 12, 78

Kiselev Ivan 20

Kissenpfennig Adrien 78

Kitic Maja 69

Kleffner Ilka 52

Klein Robyn 23

Kleinschnitz Christoph 38, 68

Kleinschnitz Konstanze 44, 84

Kleiter Ingo 39, 76

Klingbeil Christine 20

Klotz Luisa 16, 23, 41, 52, 54

Kobayashi Kunitoshi 53

Kobert Antonia 58

Koch Linda 15

Kockum Ingrid 12, 48

Kocur Magdalena 56

Koda Toru 21, 25, 83

Koellhoffer Edward 53, 68

Koenderman Leo 59

Kohyama Kuniko 70

Kolak Ufuk 57

Kolarova Michala 18

Kolasa Marcin 21

Kolster Manuela 26

Komai Kiyonobu 26

Komorowski Lars 18, 21, 64

Kondo Takayuki 77

Kondova Ivanela 27

Kondziella Daniel 48

Koni Pandelakis 87

Konno Shingo 31

Kontermann Roland 14, 82

Kooij Gijs 28

Korn Thomas 14, 77, 81

Körner Henrike 78

Kornisch Julius 50

Kosehasanogullari Görkem 19

Köster Mario 82

Kovacs Norbert 25

Kovalchuk Olga 57

Kowalak Jeffery 16

Kowarik Markus 63

Kozela Ewa 78

Kral Vlastimil 20

Krasemann Krasemann Suzanne 38

Krauthausen Marius 71

Kremmer Elisabeth 22

Krieger Charles 54

Krishnamoorthy Gurumoorthy 67, 77

Krogias Christos 82

Kropp Sonja 56

Krüger Martin 15

Krummrei Ulrike 20

Kruse Niels 37

Krynskiy Sergey 66

Krysta Anita 22, 77

Kuchroo Vijay 29

Kucukerden Melike 20, 76, 84

Kugasia Irfanali 65

Kuhlmann Tanja 23, 52, 54, 57, 80

Kuipers Hedwich 33

Kulakova Olga 20, 21

Kular Lara 47

Kulesskaya Natalia 34

Kulig Paulina 28

Kulinich Svetlana 45, 75

Kumada Satoko 25

Kumanogoh Atsushi 21, 25

Kumar Prateek 72

Kümpfel Tania 19

Kunze Anja 72

Kurihara Eiji 25

Kuroda Hiroshi 70

Kurtuncu Murat 41

Kuru Ümit 80

Kuschmann Janina 62

Kusunoki Susumu 18, 25

Kuwahara Motoi 18

Kuzmanov Ivan 23

Kyrargyri Vasiliki 38

Kyratsous Nikolaos 61

L Arnold Douglas 42

L Bollyky Paul 42

98 AUTHOR INDEX


L Dejager Philip 46

L Frederiksen Jette 17, 22, 25, 30

L Lambertsen Kate 39

L Roberts Bruce 31, 42

L Weiner Howard 58

L. Bennett Jeffrey 18, 24

L. Benson Bryan 24

L. Budui Simona 81

L. Campbell Iain 14, 49

L. Croxford Andrew 48, 80

L. Gommerman Jennifer 58

L. Holmes Gregory 32

L. Jongsma Marlieke 44

L. Kreft Karim 44

L. Lambertsen Kate 83

L. Shah Vipul 65

L. Stephenson Erin 58

L. Teeling Jessica 53

L. Teeling Jessica. 50

L. Weiner Howard 40

Laan Lisa 28

Labus Sandra 44

Labuschagne Antoinette 66

Lacher Sonja 78

Lacroix Steve 44, 51, 73

Lahl Katharina 57

Laman Jon 28

Lamb Favelle 12

Lambertsen Kate 31

Landfried Britta 36

Lang Bethan 17, 18, 68

Lang Dirk 66

Lanz Tobias 58

Largey Fabienne 18, 63

Larochelle Catherine 22, 23, 38, 49, 52

53

Laroni Alice 40, 82

Larouche Sandra 22, 23

Lassman Hans 19, 70, 71

Lassmann Hans 19, 70, 71

Laterza Cecilia 74, 75

Lattanzi Roberta 47

Lattke Michael 54

Lau Allan 32

Laudanna Carlo 81

Laura Capriotti Anna 75

Laure Garnier 84

Laurent Sarah 19

Lauria Giuseppe 22

Laversenne Vanessa 46

Leboyer Marion 69

Lee Naomi 83

Lee Priscilla 43

Lee Seunghwan 54

Lee Youjin 15

Legroux Laurine 43

Leibovitch Emily 65, 66, 83

Leikfoss Ingvild 45

Lelios Iva 27

Lemmens Evi 54

Lemmens Stefanie 54

Leonardi Tommaso 75

Leppert David 16

Lewerenz Jan 39

Leypoldt Frank 32

Li Guihong 27, 59

Li Hui 16

Li Ran 83

Li Rui 29, 58, 63

Li Xinyu 27, 59

Li Zhilin 34

Libbey Jane 68

Liblau Roland 23, 35

Liebmann Marie 52, 54

Lienenklaus Stefan 28, 66

Liesz Arthur 44

Lin Youwei 43

Lindelof Mette 48

Lindner Maren 41, 48, 70

Lindquist Sabine 80

Linehan Eimear 78

Linington Christopher 48, 70, 87

Link Jenny 48

Linker Ralf 33, 78

Lionetto Luana 40

Lippens Carla 56

Lisak Robert 43

Liu Kangding 27

Liu Mingyang 27, 59

Llovera Gemma 44

Løbner Morten 76

Locatelli Giuseppe 15, 16, 73

Lodygin Dmitri 78

Logunov Denis 69

Löhr Kirsten 50

Lohrberg Melanie 67

Loleit Verena 77

Losen Mario 69

Loser Karin 38

Losey Patrick 39

Loskog Angelica 49

Lötsch Jörn 57

Louise Mcculloug 68

Louveau Antoine 78

Lovato Laura 75

Loveless Samantha 72

Lu Haiyan 24

Lublin Fred 21

Luchtman Dirk 14, 83

Lückemann Laura 33, 34

Ludwin Samuel 15, 29, 58

Lugaresi Alessandra 48

Luger Thomas 38

Lühder Fred 39, 78

Luigi Mancardi Giovanni 82

Luigi Poliani Pietro 47

Luigi Russo Gianluca 23, 74

Lukas Dominika 39

Lumpe Katharina 31

Lund Harald 29

Lundberg Louise 83

Lundt Ramona 63

Lüth Stefan 81

Lutterotti Andreas 19, 79

Luz Avital 31

Lvovs Dmitrijs 21

Lyck Lise 31

Lyck Ruth 23, 24

Lykke Lambertsen Kate 52

Lynch Marina 27, 51, 55

Lyng Fiona 72

M Bonefeld Charlotte 30

M Bradshaw Elizabeth 46

M Dickens Alex 16

M Kaplan Johanne 31, 42

M Page Christian 45

M Siders William 31, 42

M Villar Luisa 19, 22

99

Scientific Program

M. Casasnovas Jose 63

M. Castellano Joseph 61

M. Danzer Karin 28

M. Eriksson Anna 43

M. H Khorooshi Reza 40

M. H. Khorooshi Reza 28

M. Hauck Stephanie 42

M. Hermann Dirk 52

M. Herrmann Alexander 38, 68, 78

M. Kel Junda 39

M. Kullmann Dimitri 68

M. Minogue Aedin 55

M. Otte David 63

M. Ransohoff Richard 24

M. Reichardt Holger 39

M. Rodgers Jane 37

M. Tietz Silvia 24

M. Watkins Lewis 72

Ma Chi 80

Ma Li 34

Macas Jadranka 36

Macchiarulo Giulia 79

Madar Simone 17

Madara Laurence 45

Mader Simone 18

Madore Charlotte 38, 54

Maffioletti Elisabetta 64

Magdalini Asaridou Chloi 38

Magliozzi Roberta 51

Magnus Tim 43, 48, 68

Magnutzki Alexander 54

Maier Olaf 14, 82

Mair Florian 78

Maisam Afzali Ali 47, 57

Makumbi Issa 16

Malashenkova Irina 66

Maldonado Rafael 32

Malhotra Anil 41

Malhotra Sunny 20

Malissen Bernard 42

Mallucci Giulia 75

Malviya Manish 17

Mamik Manmeet 54

Mamrut Shimrat 43

Mandeville Joseph 84

Mangsbo Sara 49

Mannara Francesco 32

Männich Julia 33, 57

Mantegazza Renato 22, 71

Manton Sean 20

Manuela Cerina 55

Manzari Caterina 66

Marcenaro Emanuela 40

Mareckova Helena 29

Maria Czarna Bahl Justyna 21

Maria Specchio Luigi 40

María Villar Luisa 49

Marignier Romain 20

Marini Chiara 52

Marion Grebing Manuela 52

Markakis Ioannis 56

Marnetto Fabiana 48

Maroso Mattia 52

Martens Gerard 33

Martha Bernanrdi Maria 49

Martin Alvaro 57

Martin Elodie 55, 72

Martin Nellie 30

Martin Roland 18, 19, 33, 63, 78

Martinelli Vittorio 40

Martínez Inés 67

Martino Davide 68

Martino Gianvito 23, 28, 37, 46, 50, 51

57, 60, 74, 75

Marventano Ivana 19, 28

Marzano Valeria 75

Marziniak Martin 38

Masaki Katsuhisa 46

Mascanfroni Ivan 29

Massoud Raya 66

Matarese Giuseppe 79

Matcovitch Orit 55

Mathias Amandine 29

Mathivanan Suresh 75

Matis Alina 48

Matos Maria 84

Matschulat Adeline 17

Matsumiya Tomoh 29, 30

Matsumoto Sadayuki 77

Matsushita Takuya 46

Mattei Carlo 40

Mattei Gianluca 16

Matthias Hermann Dirk 74

Mattick John 75

Mayer Cathrin 19

Mayo Lior 29

Mccoll Alison 55

Mccombe Pamela 46

Mccullough Louise 53, 79

Mcelroy Daniel 70

Mcgavern Dorian 83

Mchenry Alison 46

Mckenzie Brienne 54, 55

Mcmanus Roisin 55

Mebius Reina 24

Mecha Miriam 49, 51, 55

Mechelli Rosella 16, 40, 46, 66

Medynets Marie 16

Meinl Edgar 19, 42, 70, 86

Melzer Nico 17, 68

Mendozzi Laura 19, 28

Menegon Andrea 51

Mennini Tiziana 51

Menon Ramesh 28, 40, 74

Mercer Tim 75

Merkler Doron 56, 79

Merlini Arianna 74, 75

Mestre Leyre 49

Metz Imke 37, 78

Metz Luanne 57

Metzdorf Judith 76

Meuth Patrick 55, 68, 77

Meuth Sven 14, 36, 38, 55

Michel Julia 24

Michel Laure 64

Migliara Giuseppe 41

Mildenberger Iris 72

Milena Johanne Peters Eva 34

Milikovsky Dan 71

Miljkovic Djordje 84

Miller Ariel 37, 43, 62

Miller Omer 61

Mills Kingston 55

Millward Jason 28, 70, 71

Milovanovic Jelena 19, 67

Milovanovic Marija 19, 67

Minami Naoya 29

Mindorf Swantje 21

100 AUTHOR INDEX


Ming Ching Yee 25

Miranda Cláudia 78

Misgeld Thomas 69

Mishra Manoj 74

Mitchell Keith 84

Mitsui Yoshiyuki 18

Mitterling Thomas 79

Miyake Sachiko 69

Miyamoto Katsuichi 25

Miyamoto Kazuyuki 56

Miyazaki Yusei 29

Mizee Mark 13, 24

Mizrachi Tehila 17

Mizuno Toshiki 77

Mochizuki Hideki 21, 25, 83

Modvig Signe 22, 30

Mohammad Mohammad 16

Mohan Hema 23, 38

Möhle Luisa 32

Molenaar Peter 69

Molnar Tihamer 25

Momcilovic Miljana 84

Momma Stefan 36

Monsonego Alon 44, 71

Montalban Xavier 20, 49

Monteiro Susana 34

Monteleone Giovanni 40

Monteleone Ivan 40

Montresor Alessio 50

Moore Craig 15, 29, 55, 58, 63

Moos Sonja 80

Morais Mónica 34

Morando Sara 51, 56

Mørch Marlene 28

Moreira Isabel 26

Moretta Alessandro 40

Mori Yuki 22

Morley Barbara 58

Morton Paul 68

Mossakowski Agata 70

Motozaki Yuko 26

Motta Caterina 74, 79

Mues Marsilius 61

Mufazalov Ilgiz 62, 80

Müller Andreas 32

Müller Kathrin 30

Müller Marcus 71

Muller Werner 75

Munoz David 26

Muraleedharan Ranjithmenon 68

Muraro Paolo 76

Murinello Salome 53

Musio Silvia 47

Muzio Luca 28, 51, 57, 74

Mvl Santos Marcus 34

Myrtinger John 32

N Hahn Jennifer 52

N Mohebiany Alma 43

N. Detje Claudia 66

N. Lavrik Inna 32

Nacken Peter 15

Najari Abbas 26

Nakagawa Masanori 77

Nakahara Eri 70

Nakamachi Tomoya 56

Nakano Akiko 22, 53

Nakatsuji Yuji 21, 25, 83

Namaka Michael 53

Namba Akiko 21, 83

Nancy Jacquemotte 84

Narayanan Venu 55, 68

Nath Avindra 16, 70

Nau Roland 30

Naves Rodrigo 70

Ndiaye Marie 43

Neal James 72

Neefjes Jacques 44

Negri Lucia 47

Negrotto Laura 20

Neil Sarah 55

Nejatollahi Foroogh 26

Nelly Rouquié 84

Nemirovsky Anna 44

Neri Cristina 75

Nessler Stefan 24, 32, 37

Newcombe Jia 50, 58

Nibber Anjan 18

Nicholas Richard 76

Nielsen Peter 81

Niesner Raluca 19, 70, 71

Niino Masaaki 29

Nijland Philip 24

Nikbin Behrouz 26

Nilsson Ingrid 24

Nishinakamura Ryuichi 27

Nishizawa Masatoyo 42

Nizheharodava Darya 45, 75

Nonaka Takayuki 29

Novak Carina 77

Novi Giovanni 75

Novrup Hans 31

Nozaki Ichiro 26

Nur Yuceyar Ayse 25

Nurtdinov Ramil 20

Nyirenda Mukanthu 29, 63

Nytrova Petra 20

Obermeier Birgit 24

Ochi Hirofumi 77

Ochi Ryutaro 29

Odoardi Francesca 78

Oehninger Carlos 21

Oezen Iris 53, 58, 64, 72

Oflazer Piraye 81

Oger Joel 65

Ogulur Ismail 76

Ogurtsov Daniil 66

Ohba Atsuko 25

Ohgidani Masahiro 32

Ohtaki Hirokazu 56

Oishi Mariko 24

Okada Yoichiro 77

Okamoto Tomoko 79

Oki Shinji 79

Okuno Tatsusada 21, 25, 83

Olah Marta 27

Olesen Mads 73

Olsson Tomas 11, 12, 13, 24, 42, 43, 48

78

Olympiou Margarita 32

Onnis Valentina 47

Orang Torach 26

Orcen Arda 20, 84

Ortiz Yaneth 78

Ortlieb Andre 43, 48, 78

Otero Karel 70

Otten Susanne 31

Otto Benjamin 22

Ottoboni Linda 46

101

Scientific Program

Ottow Mendel 28

Ouelet Michel 23

Oukka Mohamed 14

Owens Greg 63

Owens Gregory 17, 64

Owens Trevor 28, 30, 40, 50, 76

Ozakbas Serkan 19

Ozcelik Pinar 19

Ozgun Ozden 57

P Kristensen Lars 15

P. Antel Jack 58

P. Barrett James 55

P. Heinen André 80

P. Robinson Andrew 37

P. Ruf Wolfgang 28

P. Sheridan James 77

P. Yentür Sibel 80

Paap Franziska 73

Pache Florence 28

Paes Barros Marcelo 49

Pahnke Jens 32

Palace Jacqueline 20, 26, 66

Palermo Antonia 16

Palha Joana 78

Palle Pushpalatha 30

Palmer Jeffrey 42

Pan Wei 27

Pande Nilesh 31

Pang Petti 31

Panini Nicolò 51

Pankratz Susann 38, 78

Pantaleo Giuseppe 29

Pantelyushin Stanislav 28

Paola Zoia Chiara 75

Papastergios Chrysostomos 56

Papazian Irini 75

Papp Viktoria 25

Parigger Silvia 18

Parker Chelsea 87

Parman Yesim 81

Parodi Benedetta 52, 56

Parsa Roham 47, 48

Patel Anita 68, 79

Patel Bonny 29

Patel Dipan 68

Paterka Magdalena 56

Patzig Julia 57

Paul Friedemann 19, 20, 28, 71

Paul Morgan B. 72

Pauletti Alberto 52

Paulsen Maren 53

Pedotti Rosetta 47, 50

Pedreitturia Xiomara 39, 76

Peferoen Laura 15, 30

Peitz Michael 75

Pekarek Kara 80

Pelczar Pavel 48

Pellegrino Rosa Christiane 25

Pender Michael 16, 46

Peng Haiyan 84

Perinat Therese 23

Perriard Guillaume 29, 72

Perris Roberto 51

Peschl Patrick 19

Pesic Marija 61

Pesole Graziano 66

Peter Hartung Hans 36, 77, 87

Petermann Franziska 14

Peters Nathalie 82

Petkovic Filip 84

Petrou Panayiota 75

Petrova Vasilena 64

Pfizenmaier Klaus 14, 82

Phares Timothy 17

Piacentino Gennj 50, 63, 81

Piacentino Genny 44

Piaggio Eliane 71

Piancone Federica 19, 28

Picardi Ernesto 66

Piccio Laura 15, 70

Piehl Fredrik 12, 47, 71

Piermattei Alessia 41

Pieroni Luisa 75

Pierrette Seeldrayers 84

Pietronigro Enrica 50, 63, 81

Pignolet Beatrice 35

Pignolet Béatrice 23

Piket Eliane 47

Pikor Natalia 43

Pilz Caroline 72

Pinto Vitor 34

Pinzani Lorenzo 75

Piras Eleonora 16, 40

Pittet Camille 43

Pittman Quentin 14

Planaguma Jesus 32

Planas Raquel 63, 78

Platten Michael 42, 53, 58, 64, 65, 72

Pless Ole 22

Pluchino Stefano 75

Podjaski Cornelia 22

Poelmans Geert 33

Pohl Maria 56

Pohlan Julian 70

Pointon Tiffany 20, 59

Poirier Josée 64

Policano Claudia 16, 40, 46, 66

Politis Panos 17

Polman Chris 33

Polonsky Bailey 20

Ponsaerts Peter 54

Popovic Branka 67

Poschet Gernot 72

Posevitz Vilmos 23, 41

Pot Caroline 56, 79

Poulos Kostas 81

Power Christopher 54, 55

Pramanik Gautam 62

Prat Alexandre 22, 23, 32, 36, 38, 49

52, 53, 58, 63, 64, 69

Price David 76

Prinz Immo 32

Prinz Marco 39, 60

Probert Lesley 38

Probst Christian 18, 20, 21, 64

Prozorovski Timour 56

Pryce Gareth 85

Pusch Gabriella 25

Pusch Stefan 64, 65

Pütz Benno 77

Q. Hintzen Rogier 44

Qiu Hong 58

Quach Hong 45

Quandt Jacqueline 55

Quattrini Angelo 37, 57

Quesniaux Valerie 66

Quintana Francisco 29

Qun Shi Xiang 54, 62

102 AUTHOR INDEX


R Aceng Jane 16

R Johnson Kory 16

R Lee Paul 16

R Sibson Nicola 16

R. Barnum Scott 23

R. Doeppner Thorsten 52

R. Dunay Ildiko 32

R. Mizee Mark 23

R. Simard Alain 58

Ra Bittencourt Lia 34

Racchetti Gabriella 50

Racke Michael 43

Radaelli Marta 40

Radassi Khadir 46

Radbruch Helena 19, 67, 70

Raghavan Badrinarayanan 34

Ragheb Samia 43

Rajewski Klaus 80

Rakocevic Goran 84

Raman Chander 70

Ramanujam Ryan 82

Ramberger Melanie 19, 79

Ramos Ines 72

Ranjbar Shaghayegh 26

Ranoine Anthony 62

Rao Vijayaraghava 15

Rao Vijayraghava 29

Raphael Itay 22

Raposo Catarina 56, 79

Rasouli Javad 39

Ratzer Rikke 45

Raveney Ben 79

Ravizza Teresa 52

Rawji Khalil 74

Rebeix Isabelle 13

Recasens Mireia 30, 56

Redaelli Chiara 72

Reddy Jay 15

Reddy Kalluri Sudhakar 22, 77

Reddy Kalluri Suhakar 69

Redllich Sandra 30

Reemst Kitty 40

Regen Tommy 32, 62

Regev Keren 42, 74

Reichardt Holger 78

Reichhold Christian 80

Reick Christiane 33, 82

Reijerkerk Arie 13, 23, 24

Reimer Rudolph 81

Reindl Markus 19, 20, 40, 79

Reinhart Brenda 78

Reinke Stacey 55

Reißig Sonja 80

Reiter Cory 17

Rennert Paul 63

Rentzos Michael 22

Rentzsch Kristin 20

Reuter Eva 56

Revelo Xavier 47

Revis John 66

Reyes Lilian 70

Reynolds Richard 51, 72

Rezk Ayman 63

Ria Francesco 41

Ribes Sandra 30

Ricard Jerome 31

Ricny Jan 18

Ridder Kirsten 36

Rieck Mary 42

Ringer Cornelia 58

Ripova Daniela 18

Rissiek Björn 43

Risto Rommel Frank 34

Ristori Giovanni 16, 40, 46, 66

Rita Dunay Ildiko 65

Ritchie Alanna 17, 63, 64

Ritter Anna 67

Ritzel Rodney 53, 68, 79

Rivest Serge 73

Robertson Avril 51

Robertson Neil 72

Robson Simon 29

Rocha J 66

Rochemont Viviane 56

Rodewald Sabrina 78

Rogers James 57

Rokusz Laszlo 69

Romano Silvia 16

Romero Silvina 28

Roque Susana 34, 78

Roschitzki Bernd 33

Rose Mari Elisabeth 39

Rosello Alicia 26

Rosenstiel Philip 53

Rossaint Jan 23

Rossi Barbara 24, 44, 63, 81

Rossi Chiara 57

Rossi Fabio 54

Rossi Silvia 74, 79

Rossner Moritz 72

Rostásy Kevin 19

Roth Stefan 44

Roth Valerie 28

Rothstein Thomas 41

Rothwell John 68

Rouwette Myrthe 19

Rovaris Marco 19, 28

Roy Patrick 58

Rozenberg Ayal 29, 63

Ruck Tobias 47, 57

Rudin Stefan 84

Rudolph Henriette 24

Ruffini Francesca 37, 74, 75

Ruggieri Serena 79

Rühl Geraldine 77

Ruhrmann Sabrina 46, 47

Ruitenberg Marc 16

Ruiz Anne 20

Ruland Christina 57

Ruocco Gabriella 79

Ruprecht Klemens 28, 67

Rus Horea 57

Rus Violeta 57

Rushing Elisabeth 44

Russell John 87

Ryan Katie 27

Ryazantseva Anastasia 73

Ryffel Bernhard 66

S Ousman Shalina 52

S Shihabuddin Lamya 42

S. Amaravadi Lakshmi 77

S. Domingues Helena 77

S. Dungan Lara 62

S. Elkins Jacob 77

S. Friedland Jon 37

S. Jones Raasay 55

S. Mehta Devangi 77

S. Reinboth Barbara 31

103

Scientific Program

S. Weber Martin 15, 18

S. Zamvil Scott 18, 80

Sabag Avishag 31

Sabater Lidia 39

Sabbagh Mike 22

Sabellek Pascal 52

Sack Ingolf 70

Sadovnick Dessa 63

Saft Carsten 33, 82

Sahm Felix 58, 64, 65

Sailer Andreas 80

Saini Harpreet 75

Saiz Albert 17, 20

Saji Etsuji 42

Sakoda Saburo 21, 83

Sakuma Hiroshi 25, 70

Salie Sumayah 66

Salvetti Marco 16, 40, 46, 66

Sambucci Manolo 79

Samsom Janneke 28

Samukawa Makoto 18

Sandalova Tatyana 45

Sano Yasutero 24

Sano Yasuteru 24

Sanon Nathalie 32

Santamaria Joan 39

Santos Ernestina 26

Santos Nadine 78

Saoudi Abdelhadi 42

Saresella Marina 19, 28

Sargent Ian 39

Saschenbrecker Sandra 20

Sasson Keren 82

Sato Atsushi 56

Sato Shinya 46

Sato Wakiro 77, 79

Savarin Carine 67

Saveriano Alexander 29

Sawchenko Paul 16

Saxe Simon 71

Schaefer Yvonne 69

Schaeffer Julia 75

Schaekel Knut 72

Schäfer Yvonne 22

Schambers Laura 20

Schanda Kathrin 19, 20

Scharf Madeleine 21

Schattling Benjamin 68

Schedlowski Manfred 33, 34, 65

Scheffel Jörg 30

Scheidt Uta 73

Schelmbauer Carsten 62

Scheu Stefanie 56, 57, 63

Schiffmann Susanne 33

Schippling Sven 63

Schirmer Lucas 22

Schläger Christian 78

Schlapschy Martin 82

Schlaudraff Jessica 36

Schluep Myriam 29

Schlumberger Wolfgang 21

Schlüngel Sabrina 19

Schmidt Jens 41, 44, 84

Schmidt Karsten 84

Schmidt Kim 63

Schmidt Mike 31

Schmitz Katja 31, 57

Schneider Raphael 26, 58

Schneider Reiner 56

Schramm Christoph 81

Schrank Bertold 18

Schreiber Gideon 82

Schreiber John 65

Schreiber Olivia 44

Schreiner Bettina 15, 73

Schrewe Lisa 49, 84

Schroten Horst 24

Schubert Manja 65

Schuetz Burkhard 58

Schuh Cornelia 70, 71

Schuh Elisabeth 19

Schultheiß Thorsten 30

Schultz Verena 73

Schumacher Theresa 53, 58, 64, 65

Schumak Beatrix 63

Schumann Hannah 63, 64

Schumann Timo 30

Schütze Sandra 30

Schwab Nicholas 22, 23, 38, 52

Schwartz Michal 40, 55, 56, 61, 79

Schweingruber Nils 39

Schweizer Nora 44

Schwinge Dorothee 81

Scofield Barbara 71

Sebesho Boipelo 66, 67

Seguela Philippe 29

Séguin Rosanne 15

Sehitoglu Elcin 20

Sehr Tony 30

Seidenbecher Thomas 55

Seifert Oliver 82

Sejvar James 16

Sela Michael 67, 81

Selchen Daniel 26

Selhorst Amanda 43

Sellebjerg Finn 22, 45, 46

Selter Rebecca 77

Selva Sean 17

Semenoff Tiia 70

Sen Alaattin 48, 57

Seneca Nicholas 16

Sénécal Vincent 58

Serdar Meray 31

Shahbeigi Saeed 26, 65

Shakiba Yadollah 26

Shanina Iryna 41

Shapiro Ilona 74

Sharma Akanksha 77

Shen Donghui 27

Shimizu Fumitaka 24

Shimoda Konomi 25

Shioda Seiji 56

Shirai Ikuko 25

Shirakura Takashi 83

Shrivastava Kalpana 30

Sibel Benli Ulku 53

Sica Antonio 55

Sicsic Camille 17

Siders William 85

Siffrin Volker 49, 52, 76, 83

Sifringer Marco 31

Sila Rizalar Filiz 73

Silva Claudia 52, 57, 69

Silva Ruiz Francieli 34

Sim Julia 87

Simard Alain 58

Simmaco Maurizio 40

Simo Magdolna 69

104 AUTHOR INDEX


Simons Mikael 39

Simpson Julie 72

Singh Vikramjeet 44

Sisay Sofia 26, 68

Siva Aksel 20

Sivori Simona 40

Skacikova Lucia 29

Skerra Arne 82

Slaets Helena 53, 83

Sloma Ido 29

Smith Alan 43

Smith Cassaundra 17

Smith Kenneth 48

Smith Paul 82

Sobel Raymond 33

Söderman Martin 52

Soelberg Sorensen Per 45

Soldner Claudia 66

Soltys John 17, 64

Somers Klaartje 19

Somers Veerle 19

Sommer Clemens 31

Soneson Charlotte 29

Sonner Jana 53, 58

Sophie Laffont 84

Sorokin Lydia 13, 23

Sørum Leikfoss Ingvild 43

Sospedra Mireia 18, 19, 63, 78

Soulet Denis 51

Sousa Nuno 78

Spadaro Melania 19

Spadaro Michela 48

Spampinato Simona 24

Sparwasser Tim 13, 57

Spasojevic Ivan 84

Specht Sabine 63

Spendlove Ian 77

Spurkland Anne 43

Srivastava Rajneesh 22, 69, 77

Stadelmann Christine 18, 24, 32, 36, 67

Stadelmann-Nessler Christine 36

Stahlke Sarah 76

Stangel Martin 50, 80

Starmann Julia 36

Stathopoulos Panos 40

Staudt Valerie 56

Stefan Bittner 24

Steinman Lawrence 33, 42, 47, 54

Stenzel Werner 67

Stenzinger Albrecht 53

Stephen Moore Craig 58

Sternman David 65

Stettner Mark 43, 44, 83

Stevens Jo 69

Stinissen Piet 19, 53, 83

Stöcker Winfried 18, 20, 21, 64

Stohlman Stephen 67

Stojanovic Bojana 19, 67

Stojic Aleksandar 51, 73

Stroh Albrecht 14

Ström Mikael 71

Strominger Itai 44

Stürner Klarissa 28

Sugarman Adam 57

Sültmann Holger 36

Summer Spencer 68

Sünke Mortensen Lena 67

Suresh Lakshmanan 69

Sutavani Ruhcha 77

Suter Tobias 44

Suzuki Kotoko 25

Suzuki Tomohiro 70

Svensson Emma 49

Szakacs Attila 12

Szapary Laszlo 25

Szepanowski Fabian 73

Szoke Andrei 69

Szymkowski David 31, 38

T. Bruns Oliver 81

T. Dexter David 51

T. Wipke Brian 84

Tackley George 66

Tada Satoru 83

Tækker Jensen Katrine 52

Tafferner Nadja 33

Tagel Levy Nitzan 71

Takada Kazuo 18

Takahashi Eri 29

Takahashi Hitoshi 42

Takahashi Kazuya 26

Takahashi Ryosuke 77

Takata Kazushiro 21, 25, 83

Takeshita Yukio 24

Talmon Sonja 31

Tamanito Kayo 67

Tan Matt 26

Tan Rusung 44

Tannahill Gillian 75

Tansey Malu 38

Taverna Stefano 51

Teegen Bianca 18, 21, 64

Tegeder Irmgard 31, 57

Tegla Cosmin 57

Tegnér Jesper 47

Tentillier Noemie 73

Teodorescu Roxana 21

Teodorov Elizabeth 49

Teresa Sollazzo Maria 40

Terouz Simone 22, 23, 32, 36, 69

Terskikh Ekaterina 73

Terzioglu Gulsum 48

Tesi Ray 38

Thavaneetharajah Preetheeban 54

Theodore William 65

Thewissen Kristof 83

Thien Lim Thien 25

Thom Vivian 26

Thomaidis Thomas 22

Thomas Eva 32

Thomas Katja 30

Thomas Wanet 84

Thomassen Mads 52

Thoms Sven 41

Thomson Carolyn 55

Thöne Jan 41, 82

Thue Lillevang Søren 20

Thuemmler Katja 70

Tian Li 34

Tiberi Cinzia 44

Tichauer Juan 70

Tiede Stephan 21, 64

Tischner Denise 80

Titova Marina 73

Tiwari Vijay 80

Tolosa Eva 26

Tolusso Barbara 41

Tomasso Antonio 60

Tomiki Hiroki 53

105

Scientific Program

Tomkinson Blake 84

Topcu Gulacti 57

Toscani Chiara 71

Touil Hanane 58

Toyoshima Yasuko 42

Traffehn Sarah 37

Tredwell Matthew 16

Treleaven Christopher 42

Trifilieff Elisabeth 31, 82

Trivedi Pankaj 66

Truffault Frédérique 43

Tsai Jenny 26

Tsakmakides Theofilos 48

Tsareva Ekaterina 20, 21

Tsonis Anastasios 22

Tsumuraya Tomomi 56

Tue Berg Carsten 28, 40

Tufik Sergio 34

Tukhvatulin Amir 69

Tulio Mello Marco 34

Tuller Friederike 20

Tullo Antonia 66

Tumala Susanne 34

Turan Selin 76, 84

Turano Ermanna 50, 64, 65, 74

Turati Laura 71

Turkoglu Recai 20, 84

Turley Shannon 43

Turner Michael 85

Tuzun Erdem 20, 41, 76, 81, 84

Tyagi Richa 16

Tzartos John 22

Tzartos Socrates 22

Tzekou Apostolia 73

Tzirlin Maria 74

Ubeda Carles 32

Uccelli Antonio 40, 51, 52, 56, 75, 76

82

Uchibori Ayumi 25, 26

Ufer Friederike 68

Ugidos Nerea 51

Ulbricht Carolin 19

Ulges Alexander 62

Ulndreaj Antigona 73

Ultsch Alfred 57

Umeton Renato 16

Ummenthum Kimberley 30

Unger Mandy 21

Unger Wendy 13

Urbani Andrea 75

Uruha Akinori 25

Usai Cesare 56

Uygunoglu Ugur 67

Uysal Serap 80

Uzonyi Barbara 69

V. Lanz Tobias 42

Vadis Quo 59

Valentini Mariagrazia 41

Vallieres Luc 44

Vallières Luc 73

Vandenbroeck Koen 45, 51

Vangansewinkel Tim 54

Vanhove Bernard 82

Vanwijmeersch Bart 53

Vedeler Christian 20, 65

Verbeek Marcel 47

Veremeyko Tatyana 58

Verschuur Verschuur Carl 47

Vestweber Dietmar 23

Veth Jennifer 27

Vezzani Annamaria 52, 86

Vichaya Elisabeth 51

Vieira Silvio 29

Vilano Bonamin Leoni 49

Vilarrasa Núria 78

Villacampa Nàdia 86

Vincent Angela 17, 18, 20, 68

Vinogradov Ekaterina 71

Virgintino Daniela 51

Viviane Rochemont 79

Vogel Daphne 30

Vogel Isabel 80

Vogel Zvi 78

Võikar Vootele 34

Volpe Bruce 17

Volpe Elisabetta 79

Vural Atay 26

Vural Burcak 41

W Gustavsen Marte 45

W Howell Owain 51

W Selmaj Krzysztof 42

W. Collcutt Alexander. 50

W. Howell Owain 72

W. Kamphuis Wouter 23

W. Keane Robert 44

W. Lohse Ansgar 81

W. M. Ong Catherine 37

W. Mes Steven 44

Wagner David 59

Waisman Ari 14, 32, 39, 40, 48, 62, 69

78, 80

Waldhoff Christina 46

Walker Adam 51

Walker Alesia 67

Walsh John 54

Walter Jens 67

Walter Rachel 72

Walters Winston 68

Walther Paul 54

Wang Janet 52, 69

Wang Jian 81

Wang Qing 50, 83

Wang Shengzhi 18

Wang Tonguang 70

Wang Wei Tsai Vicky 16

Wang Xu 45, 80

Wang Xuehai 49

Wang Ying 27, 59

Wang Yujia 49

Wang Zhengzheng 27

Wanke Florian 69, 80

Warford Jordan 45

Warnecke Andreas 43, 45

Warnes Gary 26

Warnke Clemens 82

Watanabe Jun 56

Waters Paddy 66

Waters Patrick 20

Waurisch Christian 81

Webb Mike 27, 84

Weber Andreas 77

Weber Frank 42, 77

Weber Martin 37

Weber Peter 77

Webster Gill 59

Wee Yong V. 52, 57, 58, 74

Weihe Eberhard 58

Weiner Howard 38

106 AUTHOR INDEX


Weishaupt Carsten 38

Weiss Ronen 31

Weiss Siegfried 28, 66

Weissberg Itai 71

Weissert Robert 41

Wekerle Hartmut 61, 67

Weller Horst 81

Welzl Hans 44

Wemlinger Scott 63, 64

Werner Hauke 57

Westhoff Dunja 59

Wettschureck Nina 80

Weydt Patrick 30

White Madeleine 59

Wichert Sven 72

Wick Wolfgang 35, 42, 53, 58, 64, 65

72

Widman Guido 17

Wiendl Heinz 16, 17, 22, 23, 37, 38, 41

47, 52, 54, 57, 78, 86

Wilcox Karen 68

Wildemann Brigitte 16

Wilk Mieszko 55

William Invernizzi Roberto 74

Williams Anna 70, 73, 78

Williams Glyn 27

Williams Sarah 73

Willing Anne 26

Wills Bridget 18

Wimmer Isabella 71

Winderl Johannes 54

Winkler Anne 18, 24

Winn Phoebe 27, 46

Winter Meike 41

Wirth Thomas 54

Witlox Joost 59

Witsch Esther 14, 62, 80

Witte Maarten 15

Wlodarczyk Agnieszka 30, 76

Wojtal Mirjana 44

Wolf Alexandra 39

Wolf Christina 76

Wolffram Kathleen 82

Woodhall Mark 20

Woodroofe Nicola 47, 72

Wostradowski Tanja 80

Wrede Arne 44

Wrzos Claudia 24, 32

Wu Chuan 15

Wu Gregory 87

Wu Jiang 80

Wu Jianping 49

Wu Linmin 27

Wu Pauline 38

Wu Qian 83

Wu Wei 27, 59

Wu Xiaokun 27, 59

Wu Xiujuan 27, 59

Wu Yan 29

Wu Yasi 54

Xiao Sheng 63

Xing Fei 29, 30

Xu Zhifang 56

Yamamoto Ken 46

Yamamura Takashi 69, 79

Yamasaki Ryo 46

Yan Jun 16, 46

Yan Shuai 27

Yanagihashi Masaru 32, 53

Yang Mu 62

Yang Siyu 27, 59

Yang Yuhong 43

Yeliseyev Vladimir 54

Yeste Ada 29

Yetimler Berrak 84

Yilmaz Vuslat 81

Yogev Nir 32, 39, 40

Yokoseki Akiko 42

Yonekawa Tomomi 46

Yong Wee 52, 57, 58, 69, 74

Yoon Jane 54

Yoshida Hidemi 29, 30

Yoshida Shigetaka 33

Yoshimura Satoshi 46

Yoshioka Yoshichika 22

You Xiaojun 77

Younan Mark 65

Yousefvand Masoud 26

Youssef Ihsen 72

Yshii Lidia 23, 35

Yssel Justin 33

Yu Dongzi 84

Yu Xiaoli 20, 59, 67

Yu Xueyang 27

Yung Hor Jyh 25

Yurkevich Marija 45

Yurkevich Mariya 75

Z Zimberg Iona 34

Zafranskaya Marina 45, 75

Zaghloul Kareem 65

Zakharova Maria 69

Zamvil Scott 18, 34, 35

Zarbock Alexander 23

Zehn Dietmar 41

Zeitelhofer Manuel 24

Zenaro Elena 50, 63, 81

Zhang Hongliang 27, 45, 59, 81

Zhang Hui 50, 83

Zhang Ji 54, 62

Zhang Xingmei 29

Zhao Chao 73

Zhu Jie 27, 45, 80

Zhukova Irina 73

Ziemssen Tjalf 30

Zierz Stephan 44

Zimmer Andreas 57, 63

Zimmermann Corinna 77

Zimmermann Julian 71

Zipp Frauke 14, 49, 52, 56, 60, 62, 76

80, 83, 87

Zisimopoulou Paraskevi 22

Zondler Lisa 28, 30

Zouvelou Vasiliki 22

Zozulya Alla 82

Zschuentzsch Jana 41

Zufall Frank 30

Zuikov Igor 66

Zujovic Violetta 13

Zuliani Luigi 20

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