Upload File

“investigating the role of micrornas in triple negative

  • Home
  • Documents
  • “Investigating the role of microRNAs in Triple Negative
1
California State University, Fresno, Department of Biology presents: “Investigating the role of microRNAs in Triple Negative Breast Cancer” Maxine Umeh PhD Candidate, Biochemistry UC Davis Friday, November 9, 2018 3:00 – 4:00 PM Science 2, room 109 For further information: www.csufresno.edu/biology Abstract: Triple negative breast cancer (TNBC) is clinically defined as tumors that lack expression of the estrogen and progesterone hormone receptors, and amplification of Her2. TNBC accounts for 10-20% of cases, and although it represents the most aggressive subtype of breast cancer, there are currently no effective targeted therapies for TNBC due to its lack of drug-targetable receptors. TNBC has the shortest time to relapse (highest metastatic rate) and lowest 3-5 year survival rate, compared to other subtypes, likely because the majority of TNBC patients show little/no response to standard chemotherapy, yet it is the only option for systemic treatment. Thus, TNBC remains both a challenge to understand and a challenge to treat, with the need to identify novel genetic drivers, signaling axes, and therapeutic targets for this breast cancer type. MicroRNAs (miRNAs) are small non-coding RNAs that negatively regulate the expression of genes through sequence specific interactions in the 3’UTR of mRNA targets, leading to translation inhibition or mRNA degradation. miRNAs have emerged as both master regulators of cancer signaling pathways and as promising targets for cancer therapy. miR-127 is a tumor suppressor miRNA that is downregulated in TNBC, suggesting that it may play a role in TNBC pathogenesis. The overall goal of our project is to investigate the biological function of miR-127 in TNBC using in silico, in vitro, and in vivo approaches. Bio: I am a 5th year PhD candidate at UC Davis in the Biochemistry, Molecular, Cell, and Developmental Biology graduate group. My educational background includes a B.S. in Developmental Biology and a M.Sc. in Quantitative and Systems Biology, both from UC Merced. I am currently in the laboratory of Dr. Sweeney where we study mammary epithelial biology and breast cancer. My research focuses on triple negative breast cancer (TNBC), which is the most aggressive type of breast cancer, significantly affecting African- American and Hispanic women, younger women, and has a lower likelihood of survival. If you need a disability-related accommodation or wheelchair access, please contact Lindasue Garner at the Department of Biology at 278-2001 or e-mail [email protected] (at least one week prior to event).

Upload: others

Post on 01-Jun-2022

2 views

Category:

Documents


0 download

Report

TRANSCRIPT

Page 1: “Investigating the role of microRNAs in Triple Negative

CaliforniaStateUniversity,Fresno,DepartmentofBiologypresents:

“InvestigatingtheroleofmicroRNAsinTripleNegativeBreastCancer”

MaxineUmehPhDCandidate,Biochemistry

UCDavis

Friday,November9,20183:00–4:00PM

Science2,room109Forfurtherinformation:www.csufresno.edu/biology

Abstract:Triplenegativebreastcancer(TNBC)isclinicallydefinedastumorsthatlackexpressionoftheestrogenandprogesteronehormonereceptors,andamplificationofHer2.TNBCaccountsfor10-20%ofcases,andalthoughitrepresentsthemostaggressivesubtypeofbreastcancer,therearecurrentlynoeffectivetargetedtherapiesforTNBCduetoitslackofdrug-targetablereceptors.TNBChastheshortesttimetorelapse(highestmetastaticrate)andlowest3-5yearsurvivalrate,comparedtoothersubtypes,likelybecausethemajorityofTNBCpatientsshowlittle/noresponsetostandardchemotherapy,yetitistheonlyoptionforsystemictreatment.Thus,TNBCremainsbothachallengetounderstandandachallengetotreat,withtheneedtoidentifynovelgeneticdrivers,signalingaxes,andtherapeutictargetsforthisbreastcancertype.MicroRNAs(miRNAs)aresmallnon-codingRNAsthatnegativelyregulatetheexpressionofgenesthroughsequencespecificinteractionsinthe3’UTRofmRNAtargets,leadingtotranslationinhibitionormRNAdegradation.miRNAshaveemergedasbothmasterregulatorsofcancersignalingpathwaysandaspromisingtargetsforcancertherapy.miR-127isatumorsuppressormiRNAthatisdownregulatedinTNBC,suggestingthatitmayplayaroleinTNBCpathogenesis.TheoverallgoalofourprojectistoinvestigatethebiologicalfunctionofmiR-127inTNBCusinginsilico,invitro,andinvivoapproaches.Bio:Iama5thyearPhDcandidateatUCDavisintheBiochemistry,Molecular,Cell,andDevelopmentalBiologygraduategroup.MyeducationalbackgroundincludesaB.S.inDevelopmentalBiologyandaM.Sc.inQuantitativeandSystemsBiology,bothfromUCMerced.IamcurrentlyinthelaboratoryofDr.Sweeneywherewestudymammaryepithelialbiologyandbreastcancer.Myresearchfocusesontriplenegativebreastcancer(TNBC),whichisthemostaggressivetypeofbreastcancer,significantlyaffectingAfrican-AmericanandHispanicwomen,youngerwomen,andhasalowerlikelihoodofsurvival.

Ifyouneedadisability-relatedaccommodationorwheelchairaccess,pleasecontactLindasueGarnerattheDepartmentofBiologyat278-2001ore-maillgarner@csufresno.edu(atleastoneweekpriortoevent).

V10: microRNAs and cancer

Expressão Diferencial de MicroRNAs no Câncer de … · destaque para os micrornas. Micrornas ... miR-1 Diminuída Supressor tumoral PNP Hudson et al. 201112 miR-221/222 Aumentada

MicroRNAs in Organogenesis and Disease

MicroRNAs in Retinal Development

microRNAs como biomarcadores do ritmo circadiano

17b MicroRNAs and Cancer - Copia

Exploiting microRNAs for precision oncology

Micrornas In Triple-Negative Breast Cancer: A Potential

MicroRNAs microRNAs Silvia Juliana Serrano Gómez BSc, MSc Coordinadora FICMAC-Lab

MicroRNAs in Cardiometabolic Diseases

V22: involvement of microRNAs in GRNs WS 2014/15 - lecture 22 1 Bioinformatics III What are microRNAs? How can one identify microRNAs? What is the function

MicroRNAs (miRNA) in Gastrointestinal (GI) Cancers

Identification of microRNAs regulating adipocyte

C. elegans microRNAs - Wormbook

Review MicroRNAs in cardiovascular disease: an

Traditional Medicine and Micrornas Inperiodontal Disease

microRNAs mediating E-selectin-dependent metastatic

Investigating the Role of MicroRNAs in the Pathogenesis of ... › bitstream › 1807 › ... · Renal cell carcinoma (RCC) is the most common adult kidney neoplasm and constitutes

Research Paper A panel of eight microRNAs is a …Research Paper A panel of eight microRNAs is a good predictive parameter for triple-negative breast cancer relapse Hsiao-Chin Hong1,2*,

EXPRESIÓN DE PROTEOGLICANOS, QUIMIOCINAS Y MICRORNAS …

MicroRNAs in the Tumor Biology of Soft Tissue Sarcomas · MicroRNAs in the Tumor Biology of Soft Tissue Sarcomas MicroRNAs in de tumor biologie van weke delen sarcomen Proefschrift

Kaposi's Sarcoma-Associated Herpesvirus MicroRNAs Target

MicroRNAs in regulation of triple-negative breast cancer … · 2 Postgraduate School for Molecular Medicine, Medical University of Warsaw, Warsaw, Poland 3 Department of Molecular

microRNAs y tumores Genitourinarios

ANA CAROLINA BERNARDINI MOULATLET MicroRNAs como

Endogenous and Synthetic MicroRNAs Stimulate Simultaneous

-Cell MicroRNAs: Small but Powerful

MicroRNAS Phosphate

Evolutionary analysis of animal microRNAs

Modeling of Cell Fate V10: microRNAs and cancer SS 2013 - lecture 10 1 … What are microRNAs? How can one identify microRNAs? What is the function of microRNAs?

RISCy business: microRNAs, pathogenesis, and viruses

Investigating Novel Genes Potentially Involved in ... · microRNAs usually map to few genomic locations, only reads mapped perfectly to the genome ≤5 times were taken. MiRDeep2

microRNAs 424 and 503 are mediators of the anti-proliferative …digital.csic.es/bitstream/10261/103756/1/microRNAs 424.pdf · 2016-02-18 · microRNAs 424 and 503 are mediators of

MicroRNAS y Miocardiopatía Hipertrófica: Análisis

microRNAs in Toxicology and Medicine