Join peers and industry expertsto discuss latest experiencesand developments in...

www.innovationwell.netFor further information on programand schedule, see

Seminars and Panel Discussions

Pre-conference workshop to advance bestpractices in KM in R&D

Knowledge Cafes for small groupdiscussions

A beautiful setting to encourage relaxeddiscussions amongst peers

...with a format designed to maximizeInterAction & Discussions...

The Network withCommunity of Practice andInnovation Activities

InterAction Meeting, 14-17 October 2008Bryn Mawr College, Philadelphia, PA. USA

Knowledge Management in R&D

Systems Biology

Computational Biology

KM in Translational Medicine

Applications of Metabolomicsin Drug Discovery & Development

Predictive ADME & Toxicology

Innovation inLife Science & HealthcareResearch & ProductDevelopment

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...and leave with a betterunderstanding of how to approach...

Vision & Strategy to Product Realities

Knowledge-Integrated ScientificInnovation

Earlier Incorporation of Safety inDesign & Development

Responding to User Requirements

Opportunities for Collaboration

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ctAdvances in Information, Communications and KM Support Systems in R&Dled by John Conway (Accelrys) and Frank Hollinger (FRESH Directions Consulting)

Frank Brown (Accelrys)Data is Only Valuable If You CanExtract the Information

Chris Culberson (Merck Research Laboratories)Title TBA

Tim McIntyre (GlaxoSmithKline)Workflow Application EnhancesProductivity

Barry Hardy (Douglas Connect)Knowledge-Oriented Collaborationin Virtual Organisation Structures

Ralph T. Mosley (Pharmasset)Going Big to Small:What Happens When You Leave Big Pharma?

Chris Smith (Pfizer)Title TBA

In this workshop Speaker Presentations and User Perspectives will be used to seed discussions on current andfuture research needs in Knowledge Management in R&D support systems, which will be carried out using awiki-supported Knowledge Cafe format.

Systems BiologyChair: Keith Elliston (GenStruct)

Speakers & Titles to be announced soon!

Stephen W. Edwards (U.S. Environmental Protection Agency)Systems Biology and Mode of Action Based Risk Assessment

Paul McDonagh (Gene Network Sciences)Reverse Engineering and Simulating CausalGenetical Genomics Networks

Christopher M.L.S. Bouton (Pfizer)Semantic Web Modeling of Biological Systems

Debraj GuhaThakurta(Rosetta Inpharmatics, Merck)Using Genetics, Gene Expression and PathwayMining in Pharmaceutical Discovery: Applicationtowards Metabolic & Cardiovascular Disorders James R. Brown (GlaxoSmithKline)

Comparative Genomics and Drug Discovery

Computational BiologyChair: Debraj GuhaThakurta (Rosetta Inpharmatics, Merck)

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Brian Gilman, (SciLink)Building Social NetworkingSystems for Scientists

John Wilbanks (Creative Commons)Breaking down Barriers to Collaboration- the Health Commons Initiative

Barry Bunin (Collaborative Drug Discovery)Community-based Collaborative Drug Discoveryfor Neglected Infectious Diseases and Cancer

Michael Liebman (Windber Research Institute)Knowledge Management Solutions for BreastCancer Biomarkers

Jerry Wright (Johns Hopkins Medical Institutions)Extending the GeneGo Pathway Analysis Platformto Understand Cystic Fibrosis

Anastasia Christianson (AstraZeneca)Translating Pre-clinical Data to Clinical Outcomes

James Golden (Science Applications International Corporation)Collecting and Aggregating Open Source Intelligence for Translational Medicine

John Speakman (National Cancer Institute)The Cancer Biomedical Informatics Grid (caBIG™):Re-engineering the Clinical Trials Enterprise

William Hayes (Biogen Idec)bioPharma Problems that SemanticWeb Technologies can solve now

Andrew McMurry (Harvard Medical School)Using Peer-to-peer Network Systems to ObtainTissue – the Achievements of the Shared PathologyInformatics Network (SPIN)

Eugene Clark (Partners Healthcare)Supporting Clinical Infrastructure and Processeswith a Genetic Knowledge Repository

Knowledge Management in Translational MedicineDavid Bousfield (Ganesha Associates)

Poster Session

Predictive ADMEAnthony E. Klon (Pharmacopeia Drug Discovery)

Anton Hopfinger (Univ. New Mexico)Novel MI-QSAR Descriptors for Use in ModelingMembrane Transport Processes Such asSkin Penetration Enhancement

Heidi Einolf (Novartis)Predictions of MetabolicDrug Drug Interactions

Yojiro Sakiyama (Pfizer)Application of Machine Learning Toolsfor in silico ADME ScreeningOlga Obrezanova (BioFocus DPI)

Automatic QSAR Modeling ofBlood-Brain Barrier Penetrationby Gaussian Processes Method

Anthony E. Klon (Pharmacopeia)Comparison of Machine LearningAlgorithms to Predict ADME

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Alvin Berger (Metabolon)Metabolomics to AdvanceDrug Discovery

John Newman (USDA)Targeted Metabolomics inDrug Discovery

Bruce Kristal (Brigham and Women’s Hospital)Diet-based Plasma Metabolomics: Biomarkersfor Disease Risk?

Pierre Beauparlant (Gemin X Pharmaceuticals)Target Identification Permits Rationale Develop-ment of the Prodrug GMX1777 for the Treatmentof Melanoma

Mark Sanders (Thermo Fisher Scientific)Title TBA

Applications of Metabolomics to Drug Discovery & DevelopmentBruce Kristal (Brigham & Women’s Hospital)

Knowledge Supper on Collaboration Opportunitiesin Predictive ADME & Predictive Toxicology

Join us for a relaxing networking evening where good foodcombines with stimulating topics for excellent conversation

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Predictive ToxicologyArtem Cherkasov (University of British Columbia)

Ann Richards (EPA)EPA DSSTox and ToxCast Project Updates:Generating New Data and Linkages in support ofPublic Toxico-Cheminformatics Efforts

Barry Hardy (Douglas Connect)The OpenTox Project

Artem Cherkasov (Univ. British Columbia)The Use of Conventional Drug Design Technologies forIdentification of Potential Endocrine Disruptors Interactingwith Sex-Hormone Binding Globulin in Zebra Fish

Alex Tropsha (Univ. North Carolina)Predictive Chemical Toxicity ModelsUsing in vitro - in vivo CorrelationsEnriched by Cheminformatics

Weida Tong (FDA)The FDA’s Endocrine DisruptorKnowledge Base (EDKB)– LessonsLearned in QSAR Modeling andApplications

Curt Breneman (RPI)A Hard Look at Predictive Modeling:How much data is enough?

Our special thanks go toCollene Wells and Dennis McHenryfor the permission to use theirphotographs of Bryn Mawr Campusin this brochure

The Network withCommunity of Practice andInnovation Activities

Register now for

Innovation in Life Science & HealthcareResearch & Product Development

5 way to register..

Online innovationwell.net(Ticket Office is only visible after login)

Online http://InnovationWell-BM810.eventsbot.com

eMail innovationwell@douglasconnect.com

Phone +41 61 851 04 61

eFax +44 870 112 38 44

Post Douglas Connect, Baermeggenweg 14,4314 Zeiningen, Switzerland

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Registration Fees Regular Academic

Full Pass $1500 $750

Day Pass (any single day) $550

Payments can be made by bank transfer, cheque orcredit card: Amex, MasterCard, Visa

Douglas Connect’s Knowledge Cafeon Knowledge and Leadership,Basel, Switzerland, April 2007