FDA-MANDATED ALTERNATIVE TO BISPHENOL-A

Kristina LennKevin MilesGregory JackettIsaac Norton

August 5, 2010

Foreshadow Introduction Effects of BPA on Human Physiology Possible Alternative Plastics to BPA Manufacturing Analysis Conclusion/Recommendation Questions

Introduction Nalgene water bottles

BPA usage

FDA regulations

Meet the Team Kristina Lenn

Project Manager Bachelor of Science in chemical engineering

with an emphasis in biological engineering Research on molecular modeling and computer

simulation Worked with Nalgene for one year

Meet the Team Kevin Miles

Team Leader during the Project Proposal Bachelor of Science in chemical

engineering with an emphasis in biological engineering

Research on tissue engineering Worked with Nalgene for one year

Meet the Team Gregory Jackett

Team Leader during the Final Presentation Bachelor of Science degree in chemical

engineering with emphasis in molecular engineering and nanotechnology

Research on fatigue-induced muscle injury Worked with Nalgene for one year

Meet the Team Isaac Norton

Team Leader during the Final Report Bachelor of Science in chemical

engineering with an emphasis in product and process design

Work experience in quality control Worked with Nalgene for one year

Background BPA=Bisphenol-A Polycarbonate Chemical in water bottles and pop cans

Problem Recognized by the human body as

estrogen Absorbed by breast tumor cells Promote breast and prostate tumor

growths

Task BPA effects Harmless Alternatives Manufacturing Techniques

BPA EFFECTS ON HUMAN PHYSIOLOGY

Kevin Miles

A Look Ahead… Previous Statements Enviornmental exposure to BPA BPA Leeching The Endocrine system BPA linked to cancer Conclusion

~ 25 ng/kg/day50,000 ng/kg/day

http://www.google.com/imgres?imgurl=http://onwardstate.com/wp-content/uploads/2008/12/water_bottle-300x300.jpg&imgrefurl=http://onwardstate.com/2008/12/20/water-water-everywhere-but-a-storage-dilemma/&usg=__qNetutbQEJVjtGWRfq72AO1LwVU=&h=300&w=300&sz=11&hl=en&start=0&tbnid=WsPcp-pgT6AipM:&tbnh=115&tbnw=114&prev=/images%3Fq%3DWater%2BBottle%26um%3D1%26hl%3Den%26sa%3DN%26rlz%3D1G1GGLQ_ENUS367%26biw%3D740%26bih%3D411%26tbs%3Disch:1&um=1&itbs=1&iact=rc&dur=244&ei=xTVPTOe5HZKlnQemi6CQBw&page=1&ndsp=10&ved=1t:429,r:6,s:0

Human Exposure: 52-74ng/kg/day

How does the endocrine system work?

BPA increased the level of hormone receptors produced by a prostate gland cell

Some dosages of BPA were environmentally relevant

An increase in cell receptors fuels growth of the cell Cells can proliferate out of control, resulting in

cancerous tumor cells.

Conclusions BPA is harmful in lower doses BPA can leech into food/beverages at

relevant levels BPA exposure increases risk of cancer

ALTERNATIVE POLYMERSGregory Jackett

The Line up The Candidates Strength Toughness Liquid Stability UV Stability Thermal Stability The Ranking

PETE(Polyethylene terephthalate)

Atactic Polystyrene(PS)

Eastman Tritan Copolyester

?

Strength

Toughness

Liquid Stability

UV Stability

Copolyester?

Thermal Stability

The Ranking

Copolyester

1st

2nd

3rd

PETE

Polystyrene

MANUFACTURING ANALYSISIsaac Norton

Forecast Polymerization Method Safety Quality Retooling Ranking

Method

Safety

Reaction

Heat

Runaway

Quality

The Ranking

Copolyester

1st

2nd

3rd

PETE

Polystyrene

Conclusions Hazardous in small concentrations Carcinogenic developmental changes

Copolyester’s better material properties

PETE’s better safety and quality properties

Our Solution Is…

PETE

Just a Reminder… The Problem BPA Effects Possible Alternatives Manufacturing Comparison The Solution

Referenceshttp://www.intuitive-recruitment.co.uk/http://fondnessforreading.blogspot.com/2008/12/melting.htmlhttp://jalopnik.com/276775/wrecking-ball-on-the-loosehttp://www.better-leadership.com/great-offices.htmlhttp://www.greenerist.com/2009/02/green-tip-get-a-bpa-free-water-bottle/http://health.allrefer.com/health/cancer-ovarian-cancer-metastasis.html

http://www.tuxedoranch.com/images/featured/bpa-free-1.pnghttp://www.sitnews.us/MacDougall/111207_PETE.jpghttp://www.extension.iastate.edu/newsrel/reiman/PolystyrenePot.jpg http://www.innovationlab.eastman.com/NR/rdonlyres/4C99D9B3-B19A-4FD5-A60F-8115B0DF5064/0/example_lrg_camelbak1.jpg

http://www.eastman.com/Brands/Eastman_Tritan/PublishingImages/TritanWater.jpg

Referenceshttp://i1.treklens.com/photos/5947/dscn0425c.jpghttp://grail.cs.washington.edu/projects/office/dewey/china/photos/yunnan/hutiaoxia/middle/middle14.jpghttp://www.jcu.edu/Philosophy/gensler/nc/images/10.jpg http://faculty.uscupstate.edu/llever/Polymer%20Resources/Isomerism.htm

http://en.wikipedia.org/wiki/File:Ester-general.svg Taylor & Francis Group. (2010) Polymers, a property database.

Retrieved from http://poly.chemnetbase.com

QUESTIONS?