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Nanotechnology

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The Scope of Nanoscience

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Nanomaterials

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Prerequisites

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Rational Design and Engineering of Delivery Systems for Therapeutics: Biomedical

Implications from Colloid and Surface Science

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Therapeutic ApplicationsNanoscale aggregates

Inorganic - inorganic core shell Inorganic - organic core shell Organic - organic core shell

Liposome Nanoemulsion Lipidnanoparticle

Quantum particle Magnetic particle Drug carrier particle

Fluorescent Drug carrier particle

DNA linked Au particles, C.A. Mirkin

PS-g-PAA micellesstained withPb(Ac)3G. Carrot, J. C. Valmalette, C.

J. G. Plummer, S. M. Scholz, J.Dutta, H. Hofmann and H.Hilborn; Colloid and Polymer

Science 276 (1998) 853-859TEM image of a negatively stainednanocapsule (A. Fery, MPI-Golm)

Solidnanoparticle

BIOMAT 190802MH

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Polyelectrolyte Approaches

Micelles

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Polyelectrolyte Approaches

Surfactants

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Polyelectrolyte Approaches

Synthetic Polycations

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Polyelectrolyte Approaches

Synthetic Polycations

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Dendrimers

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Si Di t ib ti f V i

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Size Distributions of Various

Cationic Polymer Based

Nanostructures

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Polyelectrolite Approaches

Cationic Lipids

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Cell Membrane

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The major hurdles for cellular internalization

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Phospholipids

Polar Head Groups

Three carbon glycerol

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What is a liposome?

Spherical vesicles with a phospholipid bilayer

Hydrophilic

Hydrophobic

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(2) Classification of Liposome Basedon size

SUV: Small unilamellar vesicles,

LUV: Large unilamellar vesicles,

MLV: Multilamellar vesicles,

MVV: Multivesicular vesicles

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Liposomal Formulations

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Liposomes

(A) A aqueous soluble drug encapsulated in aqueous compartment (B) A hydrophobic drug in the liposome bilayer

(C) A hydrophilic polyoxyethylene lipids incorporated into

liposome

(A) (B) (C)

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Classification of Liposomes(1) Classification of Liposome Based on Function

Conventional

Stealth:

.

Targeted: Target

ligand

Cationic: , DNA .

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Classes of Liposomes

Conventional Long circulating

Immuno

Cationic

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Methods of Preparation

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