COMPANY INFORMATION

In the 110 years and more since its founding, Amano Enzyme has flourished, in harmony with nature, in the midst of Japanese culture and tradition, with a respect for all traditional values. Since ancient times, the Japanese have been using Aspergillus oryzae to create fermented foodstuffs (i.e., sake, miso and soy sauce); thus, I think that Japan can proudly claim to be a pioneer of biotechnology. Biotechnology is one example of the brilliant human intelligence acquired from the harmonized living with nature. Historically, a central core of biotechnology is “enzymology”. Over 60 years Amano Enzyme has been able to contribute to society through the various practical applications of enzymes.　 As we enter the 21st Century, we face serious environmental issues and shortages of food, energy, and other resources, and we strive to seek the solution of achieving a sustainable recycling-based society. We believe that enzymes will come to play an increasing role in this new industrial environment. We continue to hold on to the “Amano Spirit” (“Frontier Spirit”, “Spirit of Giving”, and “Passion, Love, and Sincerity”), which has provided our guiding principles since the company’s founding. We are constantly attentive to the needs of society, and we are tireless in our efforts to create new values through our engagement and commitment to “enzymes”. We hope for your continued generous support and encouragement in the days to come.

Message from the President

PresidentMotoyuki Amano

Jizen- Spirit of Giving and Caring Our company started as “Amano Jizen-do” in 1928. Jizen in the name embodies the spirit of giving and caring, and embraces the founder’s passion to give back to society through our products and services.

Passion, Dedication and Sincerity Passion inspires people. Through our passion and tenacity, we make the impossible possible.

Incorporate dedication in everything you do. Be compassionate to others, show dedication to your work, and take pride in your community and country.

Be sincere and honest. Honesty earns trust.

Making the Intangible, Tangible A creative mind is the driving force of business. Create innovative products with a can-do spirit.

Genichi Amano,Founder

The Amano Spirit

Frontier Spirit 　We listen to customers’ voices with sincere and open minds. 　Combining this with our innovative ideas and state-of-the-art technologies, 　we will create new products that will add value to society.

Philosophy of Coexistence　For the continuous progress of society, Amano will endeavor to co-exist 　with:　 ・ Local communities and the environment 　 ・ Customers and suppliers　 ・ Employees and stockholders

Sustainable Growth　We will always be fluid and adapt to the needs of an ever-changing society. 　We utilize our expertise and resources efficiently to reach our short, 　mid and long-term goals. We strive continuously to make improvements to 　our quality of work in order to create a healthy corporation.

Since its founding over 100 years ago, Amano Enzyme has integrated the Japanese culture and key values of living in harmony with nature and sustainable use of resources. Japan is a country of Monozukuri (Japanese culture of manufacturing or craftsmanship) where highly skilled master craftsmen create products with pride and dedication to continuous improvement. We proudly carry on the tradition and strive to provide unique and high quality products and services worldwide. Through our products and services, we aim to contribute to society and make a positive impact on people's future.

Corporate PhilosophyCorporate Philosophy

Respect for Human Rights We strive to maintain a work environment free from any type of discrimination or harassment. We will not use any forced or involuntary labor, and adhere to all applicable age regulations for labor.

Employee Health and Safety We put employees’ safety as our utmost priority and adhere to all applicable health and safety laws and regulations as well as internal rules.

We encourage and support activities to maintain and improve employees’ physical and mental health.

Environmental Protection We make continuous and proactive efforts for sustainability through our business activities. We will adhere to internal environmental policies and strive to conserve and preserve the environment and natural resources.

Fair and Transparent Trade / Anti-corruption We will conduct transactions with our customers in an honest and fair manner to establish healthy business relationships.

Our selection of suppliers of raw materials, products, and services is based on fair comparison and equal evaluation.

We will not be involved in any form of bribery. We will not engage in any consultation or discussion of a corrupt nature that may influence judgement in business transactions.

Code of Business EthicsAs a responsible and trusted corporation, Amano Enzyme complies with applicable laws and regulations, as well as voluntarily implements the following policies to realize a safe and healthy work environment for sustainable growth.

R

History

Motohiro Amano1971 - 1995 President

Ennosuke Amano

Genichi Amano1948 - 1971 President

1899

1939

1948

1950

1960

1961

1969

1970

1976

1980

1981

1983

1988

1992

1993

2000

2001

2003

2006

2007

2009

2013

2018

Ennosuke Amano started pharmaceutical business.

Genichi Amano started pharmaceutical business in China.

Amano Pharmaceutical Co., Ltd. incorporated in Nagoya, Japan.

Started production of digestive enzyme, MaltDiastase.

Nishiharu Enzyme Plant opened. (fungal amylase production)

(shut down in October, 2010)

Established an Enzyme Research And Development Center.

Started production of food-processing enzyme, Glucoamylase.

Established Nagoya Enzyme Plant.

Started production of diagnostic enzyme, Lipoprotein Lipase.

Established Yoro Enzyme Plant.

Pancreatin production technology was transferred to China.

Established Amano International Enzyme Co., Ltd. in USA.

Opened a Liaison Office in Frankfurt, Germany.

Established Amano Enzyme U.S.A Co., Ltd. in Virginia, USA.

Established Amano Enzyme Europe Ltd. in U.K..

New corporate strategy “ World No.1 Speciality Enzyme Producer ”

Amano Enzyme Inc. (New corporate name)

Opened Gifu R&D Center in Gifu, Japan.

All divisions registered ISO 9001.

Acquired majority shares of Daiwa Kasei K.K..

Opened a Liaison Office in Shanghai.

Acquired all shares of IGM.

(New corporate name, Amano Enzyme de Mexico s.a. de c.v. )

Established Amano Enzyme China Ltd. in Shanghai.

(integrated into Amano Enzyme Manufacturing (china) Ltd. as Shanghai Branch, 2018)

Established Amano Enzyme Manufacturing (China) Ltd.

Merged with Daiwa Kasei K.K. and the plant started as Shiga Plant of Amano Enzyme Inc.

Amano Enzyme U.S.A. Co., Ltd. Constructed New building and started operating.

Established Amano Enzyme Asia Pacific Co.,Ltd. in Thailand.

Outline

Company Structure President

MarketingDivision

QualityAssuranceDivision

ProductionDivision

AdministrationDivision

Medical EnzymeDivision

Industrial EnzymeDivision

Gifu R&D Center

Outline /Company Structure

Name of Company

Established

Foundation

President

Business

Capital

Employees

Contact

TEL

FAX

Amano Enzyme Inc.

August 26, 1948

1899

Motoyuki Amano

1.Production and sales of enzymes for pharmaceuticals, food, diagnostics and reagents

2.Production and sales of drugs, animal drugs and feed additives

390,000,000yen

440

2-7, 1-chome, Nishiki, Naka-ku, Nagoya, 460-8630 Japan

+81- (0) 52-211-3032

+81- (0) 52-211-3054

Protein FlavorStarch BrewingFat & Oil

Business FieldMedical Enzymes

Food-Processing Enzyme

Medical Enzyme Division is working for development and marketing of enzymes for pharmaceutical and diagnostic uses. Amano Enzyme launched enzyme business with malt diastase for pharmaceutical application. A wide range of Amano enzymes from plants and microorganisms are widely used in Japan and abroad for digestive aid products, antiinflammatory enzyme preparations, chiral synthesis and diagnostic kits. Digestive enzymes are core products of Amano Enzyme, which are accepted by leading pharmaceutical companies in the world as principle active ingredients for stomach medicines.

The taste and texture of many foods we consume daily are often controlled byenzyme technology. Amano food enzymes are nowadays used in all aspects offoods, from dairy products, seasonings,alcoholic drinks to bread.As the No.1 speciality enzyme producerAmano will extend further the joy ofeating and contribute to the developmentof meal culture.

DigestionBiotransformation

Healthcare

Diagnostics

F o o d E n z y m e D i v i s i o n

M e d i c a l E n z y m e D i v i s i o n

Yoro Plant (Gifu Pref.)

Nagoya Plant (Aichi Pref.)

Shiga Plant (Shiga Pref.)

Amano Enzyme Manufacturing (China)(Jiangsu Prov., China)

Amano Enzyme Mexico

(Irapuato City, Mexico）

　Japan 　China

　Mexico

PlantsPlants

Quality AssuranceQuality Assurance

R&D OperationR&D Operation

　Food processing enzymes :・FSSC22000 certification・JAFA (Japan Food Additives Association) GMP certification・Kosher certification・Halal certification・Overseas regulation in compliance with regulatory requirements: USA（FDA GRAS）　 Europe (EU (FIAP), France, Denmark)　 Asia and Pacific (China, Korea, Australia-New Zealand (FSANZ))

　Medical enzymes :　Active Pharmaceutical Ingredient GMP

　Diagnostics enzyme :　ISO13485 certification (For Self-Monitoring of Blood Glucose)

Quality Control Center

A diverse group of scientist are striving to :

Develop Novel Enzymes Improve Quality Pursue Product Safety Improve Productivity Innovate Gene Technology Develop Screening Technology Establish Joint R&D with Customers

Gifu R&D Center

Amano Enzyme U.S.A. Co., Ltd.1415 Madeline Lane, Elgin, IL 60124 U.S.A.Tel. 1-847-649-0101Fax. 1-847-649-0205

Amano Enzyme Europe Ltd.RoundwayHouse,Cromwell Park,Chipping Norton,Oxfordshire,OX7 5SR,U.K.Tel. 44-(0)1608-644677Fax. 44-(0)1608-644336

Amano Enzyme Manufacturing (China) , Shanghai BranchC3-5F “800SHOW”, No.800,ChangDe Road, Shanghai 200040,P.R.ChinaTel. 86-(0)21-6249-0810Fax. 86-(0)21-6248-7026

Amano Enzyme Manufacturing (China) , Ltd.228 Zhongxing East Road, Siyang County, Suqian City,Jiangsu Province,223700 P.R. ChinaTel. 86-527-85226701Fax. 86-527-85226704

Amano Enzyme Asia Pacific Co., LtdRoom No.1116, Innovation Cluster 2 Building, Tower D, 111 Thailand Science Park, Phahonyothin Road, Khlong Nueng, Pathum Thani 12120, Thailand

Amano Enzyme de Mexico S.A. de C.V.Av.San Miguel de Allende 582, CD.Industrial Irapuato, GTO, 36541 Mexico Tel. 52-462-6225021Fax. 52-462-6225020

Amano Enzyme Japan

Amano Enzyme USA

Amano Enzyme MexicoAmano Enzyme Mexico

Amano Enzyme Europe

Amano Enzyme Asia Pacific

Amano Enzyme Manufacturing(China), Shanghai Branch

Amano Enzyme Manufacturing(China)Amano Enzyme Manufacturing(China)

LocationLocation

○Amano Enzyme Inc.2-7,1-chome, Nishiki, Naka-ku, Nagoya 460-8630 JapanTel.81-(0)52-211-3032 Fax.81-(0)52-211-3054

○Amano Enzyme U.S.A. Co., Ltd.1415 Madeline Lane, Elgin, IL 60124 U.S.A.Tel.1-847-649-0101 Fax.1-847-649-0205

○Amano Enzyme Europe Ltd.RoundwayHouse,Cromwell Park, Chipping Norton, Oxfordshire,OX7 5SR,U.K.Tel.44-(0)1608-644677 Fax.44-(0)1608-644336

○Amano Enzyme de Mexico S.A. de C.V.Av.San Miguel de Allende 582, CD.Industrial Irapuato, GTO, 36541 MexicoTel.52-462-6225021 Fax.52-462-6225020

○Amano Enzyme Manufacturing (China), Ltd.228 Zhongxing East Road, Siyang County, Suqian City,Jiangsu Province,223700 P.R. ChinaTel.86-(0)527-85226701 Fax.86-(0)527-85226704

○Amano Enzyme Manufacturing (China), Shanghai BranchC3-5F “800SHOW”, No.800,ChangDe Road, Shanghai 200040, P.R.ChinaTel.86-(0)21-6249-0810 Fax.86-(0)21-6248-7026

○Amano Enzyme Asia Pacific Co., Ltd.Room No.1116, Innovation Cluster 2 Building, Tower D,111 Thailand Science Park, Phahonyothin Road, Khlong Nueng, Pathum Thani 12120, Thailand

2018.12

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www.amano-enzyme.com