environmental and water resources engineering … and water resources engineering ... the...
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Date: Friday, September 16, 2016 l Time: 12-1 pm l Location: 223 Jarvis Hall Environmental and Water Resources Engineering Seminar Series
BlainePfeifer,PhDChemicalandBiologicalEngg
UniversityatBuffalo
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The Environmental and Water Resources Engineering Seminar Series is hosted in 223 Jarvis Hall every Friday from 12-1 pm. Faculties from inside and outside UB are invited to give lectures on contemporary research in relevant topics. Graduate students also participate in discussing their research in some occasions. This fall’s speaker are following.
Environmental and Water Resources Engineering Seminar Series Fall 2016
Kyle BibbyCivil and Environmental Engg
University of PittsburghEnvironmental Microbiology
Blaine PfeiferChemical and Biological Engg
University at BuffaloMetabolic Engineering and Therapeutics
Nancy LoveCivil and Environmental Engg
University of MichiganEnvironmental Biotechnology
Greg CharacklisEnvironmental Sci. and EnggUniversity of North Carolina
Water Resources Engg. & Management
Sara BehdadIndustrial and Systems Engg
University at BuffaloGreen Engineering Technology
Andrew WheltonCivil Engg./Environmental And Ecological Engg
Purdue UniversitySustainable Materials, Water and Energy
Systems, and Nanotechnology
Zoe HamsteadRENEW/Urban and Regional Planning
University at BuffaloAccess to Environmental Resources and Vulnerability to Environmental Threats
Blaine Pfeifer is an Associate Professor at the University at Buffalo, The StateUniversity of New York in the Chemical and Biological Engineering Department.He obtained his B.S. from Colorado State University followed by pre- andpostdoctoral training at Stanford University and MIT. His current research themesare heterologous natural product biosynthesis and antigen presenting cell genedelivery with heavy emphasis on developing new antibiotics and vaccines foremerging or resistant infectious diseases.
Bio-Sketch
Biosynthetic Engineering and Green Manufacturing Applications for theNonribosomal Peptide-Polyketide Siderophore Yersiniabactin
Yersiniabactin (Ybt) is a mixed nonribosomal peptide-polyketide natural product natively produced by thepathogen Yersinia pestis. The compound enables iron scavenging capabilities upon host infection and isbiosynthesized by a nonribosomal peptide synthetase featuring a polyketide synthase module. This pathway hasbeen engineered for expression and biosynthesis using Escherichia coli as a heterologous host. The biosyntheticprocess for Ybt formation has been improved through the incorporation of a dedicated step to eliminate the needfor exogenous precursor provision. Furthermore, precursor-directed biosynthesis was used to systematicallyproduce Ybt analogs. Upon doing so, resulting compounds were tested in applications that highlight the metalchelating nature of the compound. More specifically, the compounds are being tested for industrial wastewaterheavy metal removal and recovery with the goal of aiding the environmental and economic outcomes associatedwith processes across the electrical, plating, semiconductor, solar panel, automotive, and e-waste sectors.
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