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EAM-2201The Drug Enforcement Administration's Special Testing and Research Laboratory
generated this monograph using structurally confirmed reference material.
Page 1 of 5SWGDRUG.org/monographs.htmLatest Revision: 12/16/2013
Form Chemical Formula Molecular Weight Melting Point (oC)
Base C26H26FNO 387 102.2
CH3
ON
F
1. GENERAL INFORMATION
IUPAC Name: (4-Ethylnaphthalen-1-yl)[1-(5-fluoropentyl)-1H-indol-3-yl]methanone
CAS#: 1364933-60-7
Synonyms: 5-Fluoro-JWH-210, JWH-210 N-(5-Fluoropentyl) analog, (4-ethylnaphthyl)-AM-2201
Source: DEA Reference Material Collection
Appearance: White powder
UVmax(nm): Not Determined
2. CHEMICAL AND PHYSICAL DATA
2.1 CHEMICAL DATA
EAM-2201The Drug Enforcement Administration's Special Testing and Research Laboratory
generated this monograph using structurally confirmed reference material.
Page 2 of 5SWGDRUG.org/monographs.htmLatest Revision: 12/16/2013
3. QUALITATIVE DATA
3.1 NUCLEAR MAGNETIC RESONANCE
Sample Preparation: Dilute analyte to ~10 mg/mL inCDCl3 containing TMS for 0 ppm reference anddimethylfumarate as quantitative internal standard.
Instrument: 400 MHz NMR spectrometerParameters: Spectral width: at least containing -3 ppm through 13 ppm Pulse angle: 90o
Delay between pulses: 45 seconds
3.20 3.15
2
8 7 6 5 4 3 2 1 0
0
0.5
1.0
1.5
2.0
52222118111
CHCl3
TMS
Dimethylfumarate Dimethylfumarate
1H NMR: EAM-2201 Lot #RM-031113-1
7.6 7.5 7.4
8
8.5 8.4 8.3 8.2 8.1
111
4.4 4.3 4.2 4.1
211
1.75 1.50
522
EAM-2201The Drug Enforcement Administration's Special Testing and Research Laboratory
generated this monograph using structurally confirmed reference material.
Page 3 of 5SWGDRUG.org/monographs.htmLatest Revision: 12/16/2013
m/z35030025020015010050
[x 1
04 ]In
tens
ity
1
2
3
438
7
370
358
350
324
312
298
28327
0
254
241
232
212
195
183
153
144
12811
6
102
897769
41
EI+
EI Mass Spectrum: EAM-2201 Lot#RM-031113-1
3.2 GAS CHROMATOGRAPHY/MASS SPECTROMETRY
Sample Preparation: Dilute analyte ~4 mg/mL in chloroform.
Instrument: Agilent gas chromatograph operated in split mode with MS detectorColumn: DB-1 MS (or equivalent); 30m x 0.25 mm x 0.25 µmCarrier Gas: Helium at 1 mL/minTemperatures: Injector: 280oC MSD transfer line: 280oC MS Source: 230oC MS Quad: 150oC Oven program: 1) 100oC initial temperature for 1.0 min 2) Ramp to 300oC at 12 oC/min 3) Hold final temperature for 9.0 minInjection Parameters: Split Ratio = 20:1, 1 µL injectedMS Parameters: Mass scan range: 30-550 amu Threshold: 100 Tune file: stune.u Acquisition mode: scanRetention Time: 23.265 min
EAM-2201The Drug Enforcement Administration's Special Testing and Research Laboratory
generated this monograph using structurally confirmed reference material.
Page 4 of 5SWGDRUG.org/monographs.htmLatest Revision: 12/16/2013
3.3 INFRARED SPECTROSCOPY (FTIR)
Insrument: FTIR with diamond ATR attachment (3 bounce)Scan Parameters: Number of scans: 32
Number of background scans: 32Resolution: 4 cm-1
Sample gain: 8Aperture: 150
Wavenumber (cm-1)3500 3000 2500 2000 1500
%Tr
ansm
ittan
ce
20
30
40
50
60
70
30512962
293529022870
16201608
15851514
14811392 1373
13151263
1198 11611061 1047976 941
903825777 737
663 609 555528
430
Wavenumber (cm-1)1700 1600 1500 1400 1300 1200 1100 1000 900 800 700
%Tr
ansm
ittan
ce
20
30
40
50
60
70
16201608
15851560
15141481
14641450
14291392 1373
134213151277
126312341227 1198 11611128
1093 1061 10471014993976 941
903864
825795
777762
737694 663
650625
609586
555528
482469
430
FTIR ATR (Diamond, 3 Bounce): EAM-2201 Lot # RM-031113-1
EAM-2201The Drug Enforcement Administration's Special Testing and Research Laboratory
generated this monograph using structurally confirmed reference material.
Page 5 of 5SWGDRUG.org/monographs.htmLatest Revision: 12/16/2013
http://en.wikipedia.org/wiki/EAM-2201
4. ADDITIONAL RESOURCES
Wikipedia
Uchiyama, N. et.al. "URB-754: A New Class of Designer Drug and 12 Synthetic CannabinoidsDetected in Illegal Products." Forensic Sci Int. (2012),http://dx.doi.org/10.1016/j.forsciint.2012.08.047