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Page 1: Dra. Carmen Aída Martínez · @ 2011 Health -Formyl- tetrahydrofolate Pincott & o OH OH O- 5'-Phosphoribosyl- 1 -pyrophosphate INHIBITORS: AMP, GMP o- o & Glutamine + Glutamate +

Dra. Carmen Aída Martínez

Page 2: Dra. Carmen Aída Martínez · @ 2011 Health -Formyl- tetrahydrofolate Pincott & o OH OH O- 5'-Phosphoribosyl- 1 -pyrophosphate INHIBITORS: AMP, GMP o- o & Glutamine + Glutamate +

Nucleótido

• Base nitrogenada

• Monosacárido pentosa

• Grupo fosfato

Nucleósido:

• Base nitrogenada

• Monosacárido pentosa

Page 3: Dra. Carmen Aída Martínez · @ 2011 Health -Formyl- tetrahydrofolate Pincott & o OH OH O- 5'-Phosphoribosyl- 1 -pyrophosphate INHIBITORS: AMP, GMP o- o & Glutamine + Glutamate +

Nucleótido

• Base nitrogenada

• Monosacárido pentosa

• Grupo fosfato

Nucleósido:

• Base nitrogenada

• Monosacárido pentosa

Page 4: Dra. Carmen Aída Martínez · @ 2011 Health -Formyl- tetrahydrofolate Pincott & o OH OH O- 5'-Phosphoribosyl- 1 -pyrophosphate INHIBITORS: AMP, GMP o- o & Glutamine + Glutamate +

Las bases nitrogenadas se dividen en:

• Adenina

• Guanina PURINAS

• Citosina

• Timina

• Uracilo

PIRIMIDINAS

Page 5: Dra. Carmen Aída Martínez · @ 2011 Health -Formyl- tetrahydrofolate Pincott & o OH OH O- 5'-Phosphoribosyl- 1 -pyrophosphate INHIBITORS: AMP, GMP o- o & Glutamine + Glutamate +

Constituyentes de los ácidos nucleicos (ADN y ARN)

Moneda energética (ATP, GTP)

Page 6: Dra. Carmen Aída Martínez · @ 2011 Health -Formyl- tetrahydrofolate Pincott & o OH OH O- 5'-Phosphoribosyl- 1 -pyrophosphate INHIBITORS: AMP, GMP o- o & Glutamine + Glutamate +

Mediadores celulares ( AMPc y GMPc )

Constituyentes de coenzimas (NAD, FAD, CoA)

Page 7: Dra. Carmen Aída Martínez · @ 2011 Health -Formyl- tetrahydrofolate Pincott & o OH OH O- 5'-Phosphoribosyl- 1 -pyrophosphate INHIBITORS: AMP, GMP o- o & Glutamine + Glutamate +

Portadores de intermediarios

activados (UDP-galactosa, CDP-

diacilglicerol, S-adenosilmetionina)

Efectores alostericos

Page 8: Dra. Carmen Aída Martínez · @ 2011 Health -Formyl- tetrahydrofolate Pincott & o OH OH O- 5'-Phosphoribosyl- 1 -pyrophosphate INHIBITORS: AMP, GMP o- o & Glutamine + Glutamate +

Acido ribonucleico Acido

desoxirribonucleico

Page 9: Dra. Carmen Aída Martínez · @ 2011 Health -Formyl- tetrahydrofolate Pincott & o OH OH O- 5'-Phosphoribosyl- 1 -pyrophosphate INHIBITORS: AMP, GMP o- o & Glutamine + Glutamate +

AMPc: Segunda mensajero ATP: Molécula energética

FUNCIÓN DE LOS NUCLEÓTIDOS

Page 10: Dra. Carmen Aída Martínez · @ 2011 Health -Formyl- tetrahydrofolate Pincott & o OH OH O- 5'-Phosphoribosyl- 1 -pyrophosphate INHIBITORS: AMP, GMP o- o & Glutamine + Glutamate +

NAD

NAD y FAD: Transportadoras de electrones

FUNCIÓN DE LOS NUCLEÓTIDOS

Page 11: Dra. Carmen Aída Martínez · @ 2011 Health -Formyl- tetrahydrofolate Pincott & o OH OH O- 5'-Phosphoribosyl- 1 -pyrophosphate INHIBITORS: AMP, GMP o- o & Glutamine + Glutamate +

Dieta Rescate Síntesis de novo

Page 12: Dra. Carmen Aída Martínez · @ 2011 Health -Formyl- tetrahydrofolate Pincott & o OH OH O- 5'-Phosphoribosyl- 1 -pyrophosphate INHIBITORS: AMP, GMP o- o & Glutamine + Glutamate +
Page 13: Dra. Carmen Aída Martínez · @ 2011 Health -Formyl- tetrahydrofolate Pincott & o OH OH O- 5'-Phosphoribosyl- 1 -pyrophosphate INHIBITORS: AMP, GMP o- o & Glutamine + Glutamate +

Síntesis del 5-fosforribosil 1 pirofosfato

Page 14: Dra. Carmen Aída Martínez · @ 2011 Health -Formyl- tetrahydrofolate Pincott & o OH OH O- 5'-Phosphoribosyl- 1 -pyrophosphate INHIBITORS: AMP, GMP o- o & Glutamine + Glutamate +
Page 15: Dra. Carmen Aída Martínez · @ 2011 Health -Formyl- tetrahydrofolate Pincott & o OH OH O- 5'-Phosphoribosyl- 1 -pyrophosphate INHIBITORS: AMP, GMP o- o & Glutamine + Glutamate +
Page 16: Dra. Carmen Aída Martínez · @ 2011 Health -Formyl- tetrahydrofolate Pincott & o OH OH O- 5'-Phosphoribosyl- 1 -pyrophosphate INHIBITORS: AMP, GMP o- o & Glutamine + Glutamate +
Page 17: Dra. Carmen Aída Martínez · @ 2011 Health -Formyl- tetrahydrofolate Pincott & o OH OH O- 5'-Phosphoribosyl- 1 -pyrophosphate INHIBITORS: AMP, GMP o- o & Glutamine + Glutamate +
Page 18: Dra. Carmen Aída Martínez · @ 2011 Health -Formyl- tetrahydrofolate Pincott & o OH OH O- 5'-Phosphoribosyl- 1 -pyrophosphate INHIBITORS: AMP, GMP o- o & Glutamine + Glutamate +
Page 19: Dra. Carmen Aída Martínez · @ 2011 Health -Formyl- tetrahydrofolate Pincott & o OH OH O- 5'-Phosphoribosyl- 1 -pyrophosphate INHIBITORS: AMP, GMP o- o & Glutamine + Glutamate +
Page 20: Dra. Carmen Aída Martínez · @ 2011 Health -Formyl- tetrahydrofolate Pincott & o OH OH O- 5'-Phosphoribosyl- 1 -pyrophosphate INHIBITORS: AMP, GMP o- o & Glutamine + Glutamate +

oligonucleotidos

mononucleotidos Desnaturalización

Page 21: Dra. Carmen Aída Martínez · @ 2011 Health -Formyl- tetrahydrofolate Pincott & o OH OH O- 5'-Phosphoribosyl- 1 -pyrophosphate INHIBITORS: AMP, GMP o- o & Glutamine + Glutamate +

nucleotidasas

nucleosidos

nucleosidasas

Page 22: Dra. Carmen Aída Martínez · @ 2011 Health -Formyl- tetrahydrofolate Pincott & o OH OH O- 5'-Phosphoribosyl- 1 -pyrophosphate INHIBITORS: AMP, GMP o- o & Glutamine + Glutamate +
Page 23: Dra. Carmen Aída Martínez · @ 2011 Health -Formyl- tetrahydrofolate Pincott & o OH OH O- 5'-Phosphoribosyl- 1 -pyrophosphate INHIBITORS: AMP, GMP o- o & Glutamine + Glutamate +

Gota Hiperuricemia Sx. Lesch Nyhan

Page 24: Dra. Carmen Aída Martínez · @ 2011 Health -Formyl- tetrahydrofolate Pincott & o OH OH O- 5'-Phosphoribosyl- 1 -pyrophosphate INHIBITORS: AMP, GMP o- o & Glutamine + Glutamate +
Page 25: Dra. Carmen Aída Martínez · @ 2011 Health -Formyl- tetrahydrofolate Pincott & o OH OH O- 5'-Phosphoribosyl- 1 -pyrophosphate INHIBITORS: AMP, GMP o- o & Glutamine + Glutamate +

Uracilo

Page 26: Dra. Carmen Aída Martínez · @ 2011 Health -Formyl- tetrahydrofolate Pincott & o OH OH O- 5'-Phosphoribosyl- 1 -pyrophosphate INHIBITORS: AMP, GMP o- o & Glutamine + Glutamate +
Page 27: Dra. Carmen Aída Martínez · @ 2011 Health -Formyl- tetrahydrofolate Pincott & o OH OH O- 5'-Phosphoribosyl- 1 -pyrophosphate INHIBITORS: AMP, GMP o- o & Glutamine + Glutamate +
Page 28: Dra. Carmen Aída Martínez · @ 2011 Health -Formyl- tetrahydrofolate Pincott & o OH OH O- 5'-Phosphoribosyl- 1 -pyrophosphate INHIBITORS: AMP, GMP o- o & Glutamine + Glutamate +
Page 29: Dra. Carmen Aída Martínez · @ 2011 Health -Formyl- tetrahydrofolate Pincott & o OH OH O- 5'-Phosphoribosyl- 1 -pyrophosphate INHIBITORS: AMP, GMP o- o & Glutamine + Glutamate +

β-alanina:

• CMP y UMP

β-aminoisobutirato:

• TMP

CO2 y amoníaco

Page 30: Dra. Carmen Aída Martínez · @ 2011 Health -Formyl- tetrahydrofolate Pincott & o OH OH O- 5'-Phosphoribosyl- 1 -pyrophosphate INHIBITORS: AMP, GMP o- o & Glutamine + Glutamate +

CH 2 OH O H H OH HO H OH H

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