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DNA and Mutations

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DNA and Mutations

YouTube Video

http://www.youtube.com/watch?v=HMOXPhYG7dI

Mutation - any change in the DNA

Mutation

Caused by errors in DNA replication or by mutagens

Mutation

Mutations can be harmful, neutral or beneficial

Mutation

Mutations change the meaning of genes

Types of Mutations

Point mutations

Frameshift mutations

Chromosomal mutations

THE DOG BIT THE CATDNA

Types of Mutations

THE DOG BIT THE CATDNA

Substitution Mutation

THE DOG BIT THE CAR

Substitution - Replace just one letter T R

Page 10: DNA and Mutations - rbvbiotech2019.weebly.com€¦ · Types of Mutations Point mutations Frameshift mutations Chromosomal mutations. THE DOG BIT THE CAT DNA Types of Mutations. THE

Substitution MutationNormal hemoglobin DNA Mutant hemoglobin DNA

Glu ValNormal hemoglobin Sickle-cell hemoglobin

Page 11: DNA and Mutations - rbvbiotech2019.weebly.com€¦ · Types of Mutations Point mutations Frameshift mutations Chromosomal mutations. THE DOG BIT THE CAT DNA Types of Mutations. THE

THE DOG BIT THE CATDNA

Deletion Mutation

THE DOG BIT HEC AT

• Delete just one letter (T)

• Reading frame shifts

Page 12: DNA and Mutations - rbvbiotech2019.weebly.com€¦ · Types of Mutations Point mutations Frameshift mutations Chromosomal mutations. THE DOG BIT THE CAT DNA Types of Mutations. THE

Deletion MutationHemophilia - inability to form blood clots

Page 13: DNA and Mutations - rbvbiotech2019.weebly.com€¦ · Types of Mutations Point mutations Frameshift mutations Chromosomal mutations. THE DOG BIT THE CAT DNA Types of Mutations. THE

THE DOG BIT THE CATDNA

Insertion Mutation

THE DOE GBI TTH ECA T

• Add just one letter (E)

• Reading frame shifts

Page 14: DNA and Mutations - rbvbiotech2019.weebly.com€¦ · Types of Mutations Point mutations Frameshift mutations Chromosomal mutations. THE DOG BIT THE CAT DNA Types of Mutations. THE

met lys phe gly ala

met lys phe ser ala

met lys ala hisleu

NormalGene

BaseSubstitution

BaseDeletion

Page 15: DNA and Mutations - rbvbiotech2019.weebly.com€¦ · Types of Mutations Point mutations Frameshift mutations Chromosomal mutations. THE DOG BIT THE CAT DNA Types of Mutations. THE

YouTube Video

http://www.youtube.com/watch?v=vl6Vlf2thvI

Page 16: DNA and Mutations - rbvbiotech2019.weebly.com€¦ · Types of Mutations Point mutations Frameshift mutations Chromosomal mutations. THE DOG BIT THE CAT DNA Types of Mutations. THE

Stop Here

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