Volume 1 Spring 2011 Issue 3

Research Spotlight: Cranberries in Dental Research Dental Research

SUPPORTING THE OF DENTISTRY TODAY

MESSAGE from the SENIOR EXECUTIVE ASSOCIATE DEAN for RESEARCH In the College of Dentistry at the University of Tennessee, we have an obligation to instruct our dental students on the fundamentals of dentistry – both in prevention and treatment. We work to create within the students the knowledge base necessary to develop advanced skills to provide exceptional patient care. We pride ourselves – as a community-based institution – to instill in our students the desire to be engaged in public service projects to improve oral health in underserved populations. And, we give them opportunities for hands-on clinical experience with state-of-the-art technologies and procedures. But we strive to go beyond what is required or expected by a dental college – to give students graduating from UTHSC an edge in their careers, whether that be in private practice or academia. And we do this through research. In the UT College of Dentistry, students have the opportunity and are strongly encouraged to conduct a research project, under the direction of a faculty mentor, at least once during their four year tenure. Each summer, pre-doctoral students can apply to participate in the Student Summer Research Program, offered through the generous support of the Dental Alumni Association. Approximately ten to fifteen students are accepted into the program, based upon project merit, clinical significance, and feasibility. These students are awarded a stipend to carry out their projects and then present at one to two research conferences. As is exemplified in this issue of Dental Research, students are taking advantage of this opportunity to gain research experience before graduating from UTHSC. Thirty-one students presented their research projects at the Annual Student Research Day held on the Memphis campus this past February. In addition, fourteen of those students also gave poster presentations at the Hinman Student Research Symposium that was held last October in Memphis and twelve students gave presentations at the annual American Association for Dental Research/International Association for Dental Research joint meeting held in San Diego in March. These students will take away from this experience more than just an increased knowledge of dentistry. This program’s importance also stretches beyond the student – enhancing the experience of the faculty mentors by introducing new perspectives into ongoing research, improving the policies and practices in the patient clinics, and heightening the engagement level throughout. Here at UTHSC, we are very proud and excited about what the future will bring with our student researchers!

Franklin Garcia-Godoy, D.D.S., M.S.

2011 Student Research Day

New Department Chairs in the College of Dentistry

Dental Research edited by: Laurie Wedel, M.A.

Communications Specialist | Research Coordinator

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RESEARCH FACULTY and STAFF

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DENTAL RESEARCH NEWS Student Research Day | IADR/AADR Annual Meeting

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COLLEGE of DENTISTRY NEWS New Chairs in Endodontics and Restorative Dentistry | Spring Deadline for Alumni Grant

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QUARTERLY RESEARCH SPOTLIGHT Cranberries in Dental Research

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CLINICAL RESEARCH 9 PUBLICATIONS and PRESENTATIONS

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GRANTS and SPONSORSHIPS

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AWARDS and HONORS

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Oral health is a mirror for general

health and well-being

David Satcher U.S. Surgeon General

May 2000

Inside this Issue

Dr. Laura Darnell (left) and Dr. Anastasios Karydis (right) examine a subject during a clinical research study.

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SENIOR EXECUTIVE ASSOCIATE DEAN for RESEARCH Franklin Garcia-Godoy, D.D.S., M.S.

Chair, Department of Bioscience Research Director, Bioscience Research Center

Professor, Department of Physiology, University of Tennessee Health Science Center Adjunct Professor, Department of Biomedical Engineering, University of Memphis

Adjunct Professor, Department of Biomedical Engineering, Florida International University Senior Clinical Investigator, The Forsyth Institute, Boston, Massachusetts

Adjunct Professor, Department of Conservative Dentistry and Periodontology, University of Munich

FACULTY

Jegdish Babu, B.S., M.S., Ph.D. Associate Professor

Melody Barron, D.D.S.

Assistant Professor Director, TMD/Sleep Disorder Clinic

Mustafa Dabbous, M.S., Ph.D.

Professor

Edward Harris, Ph.D. Professor

Christopher Nosrat, D.D.S., Ph.D.

Professor

Mark Scarbecz, Ph.D. Professor

Director of Planning and Assessment

Edwin Thomas, M.S., Ph.D. Professor

David Tipton, D.D.S., Ph.D.

Professor

Antheunis Versluis, Ph.D. Professor

Director of Biomaterials

STAFF Brandy Clark, CDA, RDA Clinical Dental Assistant Kimberly DeMonaco, R.D.H. Clinical Research Associate Margaret Jefferson Sr. Research Assistant Geraldine Moore Lab Assistant Irina Vukamanovic Nosrat, D.D.S. Research Team Leader Iva Pendleton Admin Service Assistant Michelle Sims, B.S. Research Coordinator Nancy Turner Administrative Aide Linda Vincent TMD/Sleep Disorder Clinic Coordinator Laurel Wedel, B.A., M.A. Grants & Clinical Research Coordinator Yanhui Zhang, B.S., M.S., Ph.D. Research Associate

Research Faculty and Staff

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Joshua Veltri, Dentsply North America, presents Charles Puryear (D3) with the Student Clinician Award.

COLLEGE of DENTISTRY STUDENT RESEARCH DAY 2011 The University of Tennessee College of Dentistry held its annual Student Research Day and Table Clinic Competition on February 15, 2011 at the Student Alumni Center (SAC) in Memphis. Thirty-one students presented their summer research projects in twenty-six posters and table clinics. The 2011 Student Research Day was opened by Dr. Franklin Garcia-Godoy, Senior Executive Associate Dean for Research in the College of Dentistry. Dr. Antheunis Versluis, the new Director of Biomaterials, gave the keynote address on “Stress in Dentistry,” which was based on his internationally recognized research in which he developed advanced finite element analysis techniques that can be applied to biomechanics and biomaterials in dentistry. Following the keynote address, the thirty-one students presented their research projects as posters or table clinics. Presentations were judged by a panel of faculty, alumni, and sponsor representatives. Third-year dental student, Charles Puryear, was selected as the winner of the Student Clinician Award for the most outstanding clinical presentation. His project, Developing a Fixture Level Cast for Implants with Interfering Axial Convergence, presented an approach to solving a difficult clinical problem for patients with adjacent dental implants that do not have a parallel alignment. Puryear was mentored by Drs. Russell Wicks, Swati Ahuja, and Vinay Jain, all faculty in the Department of Prosthodontics. In October, Charles will represent UT in the student poster competition of the American Dental Association Annual Session in Las Vegas, Nevada. This award was sponsored by the Dentsply Corporation and was presented by Dr. Franklin Garcia-Godoy and Joshua Veltri, Key Account Manager for Dentsply North America. Also receiving awards at the event were Britney Taylor, winner of the Harold Cloogman Award, and Shawna Clark, Ashlee Franklin, Bryan Lee, and Nia Zacharia, winners of the James C. Ragain Awards for Student Research. These students also presented their projects at the Hinman Student Research Symposium, which was held at the Peabody Hotel in Memphis this past October, and at the American Association for Dental Research (AADR) meeting this past March in San Diego. Dr. Norman Fine, graduate student in Periodontology, received the Graduate Program Research Award for his presentation, Activity of Human Epithelial Cell Defensin HBD-3 against a Periodontal Pathogen. He was assisted by Dr. Edwin Thomas, professor in the Department of Bioscience Research. Dr. Fine’s research project was supported by a Category I Research Grant through the UT Dental Alumni Endowment Fund for Research. The pre-doctoral research projects were supported by the Student Summer Research Program, funded through the UT Dental Alumni Endowment Fund for Research. DENTAL ALUMNI APPROVE INCREASE to STUDENT RESEARCH PROGRAM In connection with the Mid-South Dental Congress, held this past March at the Hilton Memphis, the Dean’s Executive Committee, comprised of dental alumni representatives, motioned to expand the support of the Student Summer Research Program. This motion was sent to the Board of Trustees of the Dental Alumni Association and was approved, which will increase funding to support more student projects. In addition, students will be offered a larger stipdend for their research projects. This increased funding will be assessed on a yearly basis to allow for the maximum number of students to participate in research during their pre-doctoral studies. To learn more about the Student Summer Research program, please visit: www.uthsc.edu/dentistry/research.

Dental Research News

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UT at the AADR/IADR ANNUAL MEETING in SAN DIEGO The University of Tennessee College of Dentistry had 19 faculty members and 12 students give presentations at the 2011 American Association for Dental Research (AADR)/International Association for Dental Research (IADR) Annual Meeting held in San Diego, California on March 16th – 19th. The presentations included one oral presentation, one poster-discussion, and twenty-two posters. This was the largest representation by UT at the AADR/IADR meeting, which helps to establish UTHSC as a leader in dental research. The following are the presentations (listed alphabetically by title according to date of presentation): Thursday, March 17th

• Bisphosphonates Impair the Adhesion of Gingival Fibroblasts and

Epithelial Cells. Karydis A, Tipton D, Garcia-Godoy F. • CBCT Analysis of the Oropharynx: Effects of Age and Sex. Streight RA,

Harris EF. • Color Stability of Different Resin Composites Immersed in Beverage

Solutions. Puppin-Rontani J, Puppin-Rontani RM, Garcia-Godoy F. • Composite Properties and Stress Effects with Different Restorative

Techniques. Soares CJ, Versluis A, Tantbirojn D. • Effects of Water Line Disinfectants on the Composite Bond. Stanford C,

Garcia-Godoy F, Darnell L. • Growth of the Nasopharynx: A Three-Dimensional CBCT Study.

Fagala KD, Streight RA, Harris EF. • Inflammatory and Toxicity Effects of Dental Composites on Gingival

Fibroblasts. Sykes B, Tipton D, Garcia-Godoy F, Babu JP. • Quantified Tooth Surface Loss Associated with Gastroesophageal Reflux Disease. Tantbirojn D, Pintado MR, Versluis A,

Dunn C, Delong R. • Shrinkage Compensation by Hygroscopic Expansion in Low-Shrink Composite Restorations. Versluis A, Tantbirojn D,

Delong R. • Thermal Absorption of CO2, Nd:YAG, Diode Lasers in Dental Biomaterials. Kiling E, Migliorati E, Drukteinis S, Roshkind

DM, Hardigan P, Bradley P.

Friday, March 18th

• Analysis of Biofilm Formed on Dental Composite Resins. Clark S,

Garcia-Godoy F, Babu JP. • Anti-inflammatory Effects of Cranberry Components on Human Gingival

Epithelial Cells. Zacharia N, Tipton D, Rawal S, Dabbous M. • Effects of Cranberry Components on Human Aggressive Periodontitis

Gingival Fibroblasts. Tipton D, Babu J, Dabbous M. • Effects of Glove Contamination on Composite Resin Bond Strengths.

Brown I, Garcia-Godoy F, Darnell L. • Effects of Handpiece Lubrication on Composite Bond. Denson N,

Harrison J, Garcia-Godoy F, Darnell L. • Efficacy of 2-Hour Whitening Strip under Extended Use Conditions.

Simon JF, Lewis MW, Powell L, Wilson N, Conde E, Anastasia MK, Ovando B, Farrell S.

• Inhibition of Bacterial Adhesion to Epithelial Cells by Oral Rinses. Diaz ME, Babu JP, Garcia-Godoy F.

• Racial Differences in Tooth Mineralization Among Three U. S. Groups. Harris EF.

Students Kyle Fagala and Ryan Streight present a poster at the IADR/AADR in San Diego

Student Tiffany Stuart (left) with her mentor, Dr. Franklin Garcia-Godoy, and Mrs. Garcia-Godoy

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Saturday, March 19th

• Dental Care System and Hopsital ED Visit for Dental Care. Hong L, Liu Y,

Garcia-Godoy F, Cai J, Hoff G. • Effects of Cleaning Solutions on Resilient Denture Material. Stuart T, Hollis

W, Garcia-Godoy F, Darnell L. • Effects of Staining Solutions and Cleansers on Hard Denture Material. Holley

T, Hollis W, Garcia-Godoy F, Darnell L. • Plasma Treatment Effects on Oral Bacterial Deactivation. Yang B, Ritts A, Yu

Q,Li H, Yao X, Wang Y, Hong L, Chen M, Jones J. • Resistance of All-Ceramic Crowns. Combest P, Simon JF, Garcia-Godoy F,

Darnell L.

DEVELOPING a STANDARDIZED PROCESS for RESEARCH REPORTS and SUBMISSIONS As the dental research program grows at the University of Tennessee, it becomes important to create a standardized process for submitting and tracking grants/contracts, publications, and presentations. The following two guidelines are being developed to help improve the current system in the College of Dentistry. The first guideline applies to submitting grants and contracts, requesting that all grants and contracts paperwork be routed to the Grants & Clinical Research Coordinator (lwedel1@uthsc.edu) before it is routed to the Office of Research Administration (ORA). Currently, UTHSC has a five (5) working day policy where all grants and contracts paperwork must be received by ORA at least five working days prior to the official grant/contract deadline. This provides ORA staff with adequate time to review the documents and generate institutional approvals. This new guideline would ask all faculty/students submitting a grant/contract (including CDA, MTA) to submit that paperwork to the Grants & Clinical Research Coordinator seven (7) working days prior to the official deadline (two extra days before the ORA deadline). This will allow adequate time for department/college approvals to be obtained and will allow the Grants Coordinator time to review the grant (in particular the budget) and submit to ORA a standardized, polished grant/contract package. * As a reminder, it is recommended that all researchers consult the Grants & Clinical Research Coordinator about the budget during the planning stages of the grants process. The second guideline applies to research activity tracking, requesting that all faculty members report their research activities to the Grants & Clinical Research Coordinator soon after they are realized. “Research activities” include grants (submitted and awarded), publications (submitted, accepted, electronically published ahead of print), presentations, and awards/honors (as they relate to research). Please send all the details of these activities, including all author/investigator names, titles, journal/book names, volume/issue/edition, and conference name, location, and dates. By efficiently providing this information to the Grants & Clinical Research Coordinator, these activities can be tracked more effectively and department, college, and university reports will be more accurate. If you have any questions about these new guidelines, please contact Dr. Franklin Garcia-Godoy, Senior Executive Association Dean for Research (godoy@uthsc.edu) or Laurel Wedel, Grants & Clinical Research Coordinator (lwedel1@uthsc.edu).

(From left) Mentors Dr. David Tipton, Dr. Jegdish Babu, and Dr. Franklin Garcia-Godoy with student

researcher, Britney Taylor

Dr. Antheunis Versluis had 3 presentations at the 2011 meeting

Dr. Antheunis Versluis presented three research projects

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NEW CHAIRS in the DEPARTMENTS of ENDODONTICS and RESTORATIVE DENTISTRY The Departments of Endodontics and Restorative Dentistry have both recently welcomed new chairs.

Dr. Adam Lloyd, B.D.S., M.S. is an associate professor in the Department of Endodontics. Dr Lloyd played a vital role in the approval for the College to offer a graduate program in Endodontics and has been actively involved in research since he joined the dental faculty in September 2009. Dr. Lloyd accepted the chair position in February 2011.

Dr. Janet Harrison, D.D.S., is a professor in the Department of Restorative Dentistry (formerly known as Operative Dentistry). Dr. Harrison served as co-chair of the Operative and Endodontics Department and division chief of Operative Dentistry before accepting the chair position of the new stand-alone department in November 2010. The College of Dentistry is excited to have Drs. Lloyd and Harrison in these administrative roles. Currently, the College is conducting a search for Chairs of the Department of Pediatric Dentistry and Community Oral Health and the Department of Orthodontics. Please visit: www.uthsc.edu/dentistry/Fac_Depts/jobs.php for more infomration on these positions.

UT DENTAL ALUMNI ENDOWMENT for RESEARCH SPRING GRANT DEADLINE

As a reminder to faculty and students - the UT Dental Alumni Endowment for Research will be accepting research grant proposals through Friday, April 29th.

This request for proposals is a semi-annual competitive request with deadlines in April and October. Proposals for research must follow the guidelines set forth by the Dental Alumni (available by request from lwedel1@uthsc.edu) and must be submitted electronically to the Senior Executive Associate Dean for Research (godoy@uthsc.edu) or the Grants Coordinator (lwedel1@uthsc.edu) by 5:00 pm on the 29th.

Please note recent changes to the guidelines for proposals to the Endowment for Research:

• Clinical Significance: all proposals must include a short paragraph explaining the clinical relevance of the proposed research project.

• Budget Consultation: when developing your budget for an Alumni Endowment for Research grant, you are strongly encouraged to consult with the Grants Coordinator to ensure that all necessary costs are included and that the budget is appropriate.

• Outcome Measures: please include a plan for publication and presentation of research AND a plan for future funding should your research develop into an ongoing project.

• Contingency Plan: this feature of the guidelines is not new but commonly neglected. Please describe your plan for research should any or all of the investigators be separated from the College of Dentistry for employment, graduation, or health reasons.

• Cover Letter: this feature of the guidelines is also not new, but often overlooked. All grant proposals should include a cover letter, printed on letterhead and signed by all investigators.

College of Dentistry News

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CRANBERRIES in DENTAL RESEARCH As adjunctive periodontal therapy, essential oils and other plant products (i.e., cayenne, myrrh oil, tea tree oil, eucalyptol) have been used since antiquity to control mouth odor, pain, and inflammation associated with periodontal disease. Cranberry (Vaccinium macrocarpon), a native North American polyphenolic-rich fruit, which has been shown to inhibit human cancer cell line proliferation and prevent adherence of urinary tract infectious agents, may also be useful in the treatment/prevention of oral diseases. In vitro studies using a molecular-weight fraction of non-dialyzable material (NDM) prepared from cranberry juice, which is rich in proanthocyanidins, showed that the NDM inhibited the coaggregation of many oral bacteria and affected dental biofilm formation, and inhibited inflammatory activities of human macrophages and other cells. This research on the anti-adherence and anti-inflammatory activities of cranberry components has been the ongoing focus of the studies conducted by Dr. Jegdish Babu and Dr. David Tipton, both faculty in the Department of Bioscience Research. Initial Research Prior to 2009, Dr. Babu, in collaboration with Dr. Jacob Shiloah (Professor, Department of Periodontology) and Dr. Itzhak Ofek (Professor, Tel Aviv University) began the initial investigations of the effect of cranberry NDM on the removal of biofilm formation on hydroxyapatite discs. NDM was found to be extremely effective in detaching biofilm and preventing its formation. The research focus then shifted to the effect of NDM on Candida biofilm formation on dental acrylic products – formation that would cause stomatitis. Further studies during this time period revealed that NDM is bacteriostatic rather than bactericidal. In addition, these studies showed that NDM inhibited several constituents of dental biofilm (i.e., glycosyltransferase and fructosyltransferase) and the adhesion of Streptococcus sobrinus. Recent Research Since 2009, Drs. Babu and Tipton have worked under a grant from the Cranberry Institute to investigate the effects of cranberry components on denture-related stomatitis and inflammatory reactions of gingival fibroblasts in aggressive periodontitis. Dr. Babu and Britney Sykes-Taylor: Supported by a stipend from the Dental Alumni Student Summer Research Program, Dr. Babu, along with dental student Britney Sykes Taylor, conducted a study to clarify and define more effective modes of preventing and treating oral inflammatory disease, such as denture-related stomatitis (DRS), which can result in pain, tissue destruction, and loss of function. DRS is caused by a tenacious inflammatory disease caused by the fungus Candida albicans. This study examined the effects of incorporating cranberry NDM into denture cleansers and tissue conditioners in an effort to see if NDM could prevent DRS by attacking and dissolving the safe-haven “biofilm” created by the fungal pathogen. Dr. Babu and Britney also studied the effect of NDM on the attachment of selected oral bacteria to saliva coated and uncoated titanium implant surfaces. Dr. Tipton and Nia Zacharia: Also supported by a stipend from the Dental Alumni Student Summer Research Program, Dr. Tipton, along with dental student Nia Zacharia, and in collaboration with Drs. Babu, Mustafa Dabbous (Bioscience Research), and Swati Rawal (Periodontology), conducted a study to investigate the role that cranberry NDM plays in the prevention and treatment of gingivitis and periodontitis. This study found that in aggressive periodontitis fibroblasts stimulated with products from bacteria that cause periodontal disease, cranberry NDM inhibited tissue-destructive matrix metalloproteinases (such as MMP-3) and a factor which promotes inflammation. In gingival epithelial cells, NDM inhibited expression of pro-inflammatory molecules (such as interleukin-6 and prostaglandin E. These results suggest that cranberry components may regulate oral fibroblast and epithelial cell inflammatory responses and may be useful as a host modulatory therapy (HMT) agent to prevent or treat gingivitis and periodontitis. New Projects Currently, Drs. Babu and Tipton are working with post-doctoral students to further explore the role of cranberry components on oral health. Dr. Tipton is working with Dr. Thomas Carter to explore how cranberry NDM interferes with cellular signaling pathways that stimulate IL-6 production in human gingival epithelial cells. Dr. Babu is working with Dr. Vreiti Sangha on a project that examines the effect of cranberry components on the biological activity of LPS molecule, in particular, the prevention and treatment of P.gingivalis-associated periodontal diseases. Drs. Tipton and Babu have also applied for continued funding from the Cranberry Institute to study the potential benefits of cranberry products in treating periodontitis in patients with diabetes mellitus.

Research Spotlight

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The following is a list of current clinical research studies being conducted by UT College of Dentistry faculty. The title, investigators, and study objective are listed for each project.

A comparison of the effects of occlusal adjustment and splint therapy on symptoms reduction in TMD

Study Objective: The purpose of this study is to compare the effectiveness of occlusal adjustment and splint therapy on the therapeutic management of temporomandibular dysfunction (TMD).

Principal Investigator: Dr. Swati Ahuja

Co-Investigators: Dr. David Cagna

Dr. William McHorris

Influence of maternal factors on caries development during early childhood (Ancillary Study to the CANDLE Study)

Study Objective: The purpose of this study is to investigate the impact of maternal factors on the development of dental cavities among 3 years old children.

Principal Investigators: Dr. Franklin Garcia-Godoy

Dr. Liang Hong

Co-Investigator: Dr. Fran Tylavsky (Preventive Medicine)

Oral Streptococus species in pre-term and full-term 24-36 month old African-American children in Memphis, Tennessee – A cross-sectional study

Study Objective: The study objective is to investigate five Streptococcus species commonly found in the oral biofilm of children, specifically Streptococcus mutans, Streptococcus sobrinus, Streptococcus mitis, Streptococcus sanguinis, and Streptococcus salivarius to determine their relative numbers in 24-36 month old healthy African-American pre-term and full-term children residing in Memphis, Tennessee.

Principal Investigators: Dr. Renalie Rebong (Pediatric Resident)

Dr. Emily Fourmy (Pediatric Resident)

Co-Investigators: Dr. Franklin Garcia-Godoy

Dr. Jegdish Babu

Consultant: Dr. Reddy Dhanireddy

Research Staff: Laurel Wedel (Research Coordinator)

Clinical Research

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The following is a list of publications by College of Dentistry faculty from January 2011 to present, and recent as well as upcoming presentations. PUBLICATIONS Ahuja SA, Wicks RA. Shielding Techniques and Mouthguards. In Dental Horizons, Essentials of Oral Health, 1st ed. 2011. pp.22-30. Dabbous MK, Jefferson MM, Haney L, Thomas EL. Biomarkers of metastatic potential incultured adenocarcinoma clones. Clin Exp Metastasis. 2011 Feb;28(2):101-11. Epub Nov 23 2010. PMID: 21104427. Shin DH, Yun DI, Park MG, Ko CC, Garcia-Godoy F, Kim HI, Kwon YH. Influence of DPSS Laser on Polymerization Shrinkage and Mass Change of Resin Composites. Photomed Laser Surg. 2011 Mar 21 [epub ahead of print]. Raluca P, Krejci I, Garcia-Godoy F, Bortolotto T. Noncarious cervical lesions – A clinical concept based on the literature review. Part 1: Prevention. Am J Dent. 2011 Feb;24(1). Cardoso-Silva C, Barberia E, Maroto M, Garcia-Godoy F. Clinical study of mineral trioxide aggregate in primary molars. Comparison between grey and white MTA-A long term follow-up (84 months). J Dent. 2011; 29:187-193. Kühnisch J, Bücher K, Henschel V, Albrecht A, Garcia-Godoy F, Hickel R, Heinrich-Weltzien R. Diagnostic performance of the Universal Visual Scoring Sytem (UniViSS) on occlusal surfaces. Clin Oral Invest. 2011;15:215-223. Harris EF, Barcroft BD. American Black-White Differences in Primary Tooth Crown Shape: The Crown Index. Dental Anthropology. 2010;23(3):83-88. Hong L, Ahmed A, McCuniff M, Liu Y, Cai J, Hoff G. Secular trends in hospitality emergency department visits for dental care in Kansas City, Missouri, 2001-2006. Public Health Reports. March-April 2011;126:210-219. Scarbecz M, Russell CK, Shreve RG, Robinson MM, Scheid CR. Faculty development to improve teaching at a health sciences center: A needs assessment. J Dent Edu. 2011 Feb; 75(2):145-149. Dean IN, Stein SH. Osteoinductive and osteoprotective characteristics of statins. J Intl Acad Periodontol. 2010 Dec;12:70-75. Tantbirojn D, Pfeifer CS, Braga RR, Versluis A. Do low shrinkage composites reduce polymerization shrinkage effects? J Dent Res. 2011 Jan 31 [Epub ahead of print]. Tipton DA, Seshul BS, Dabbous MKh. Effect of bisphosphonates on the production of mediators of osteoclastogenesis (RANKL, OPG, and IL-6) by human gingival fibroblasts. J Periodontal Res. 2011 Fe;46(1):39-47. Versluis A, Tantbirojn D, Lee MS, Tu LS, Delong R. Can hygroscopic expansion compensate polymerization shrinkage? Part I: Deformation of restored teeth. Den Mater. 2011 Feb;27(2):126-33. PRESENTATIONS Dr. Melody Barron (Bioscience Research) has been invited to give a lecture on “Sleep, Oral Appliances for OSA – the Physician/Dentist Connection,” for Pulmonology Fellows in the UTHSC College of Medicine. Dr. Barron’s lecture is scheduled for April 26th.

Publications Presentations

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The following is a list of current grants/sponsorships held by UT College of Dentistry faculty. FEDERAL/FOUNDATION GRANTS

• Influence of cranberry juice components on denture related stomatitis and inflammatory reactions of gingival fibroblasts

o PI: Jegdish Babu, B.S., M.S., Ph.D. (Bioscience Research) o Co-PI: David Tipton, D.D.S., Ph.D. (Bioscience Research) o Cranberry Institute of Wisconsin (Private Grant) o $40,200

• Biocompatibility screening of restorative treatments o PI: Franklin Garcia-Godoy, D.D.S., M.S. (Sr Exec Assoc Dean for Research/Bioscience Research) o NIH High Priority, Short-Term Project Award (R56) o Amount: $135,000

• Hinman Student Research Symposium o PI: Franklin Garcia-Godoy, D.D.S., M.S. (Sr. Exec Assoc Dean for Research/Bioscience Research) o NIH/NIDCR (R13) o Amount: $20,000

• Development of miniature plasma brush for dental clinical applications o Co-I: Liang Hong, D.D.S., M.S., Ph.D. (PDCH/Director of Community Oral Health) o NIH/NIDCR (R44 SBIR Phase II) o $402,000

SPONSORSHIPS

• Evaluation of the CS-9300 o PI: Lawrence Weeda, D.D.S. (Oral & Maxillofacial Surgery) o Carestream Dental

• Visualization of sealer movement during single-cone obturation with EndoSequence BC Sealer

o PI: Adam Lloyd, B.D.S., M.S. (Endodontics) o Real World Endodontics/Brasseler USA

Grants Sponsorships

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The following is a list of recent research-related Honors and Awards.

On March 16-19, 2011, the International American and Canadian Associations for Dental Research hosted a joint meeting in San Diego, CA. At this meeting, three University of Tennessee College of Dentistry

faculty members were elected to the Executive Committee of the American Association of Oral Biologists (AAOB), for the period of March 2011 – March 2013.

• Dr. David Tipton (Bioscience Research) was elected Secretary-Treasurer. • Dr. Mustafa Dabbous (Bioscience Research) was elected Program Director. • Dr. Edwin Thomas (Bioscience Research) was elected Chair of the Awards Committee.

Congratulations to these three faculty members! Also at this joint meeting of the International American and Canadian Associations for Dental Research, Dr. Franklin Garcia-Godoy, Senior Executive Associate Dean for Research, received an award as former President of the IADR/AADR Cariology Division “For Promotion of Dental Research World-Wide.” REQUEST for NEWS and INFORMATION: If you have any research-related news or information that you would like to have included in the Summer 2011 (Vol. 1, Issue 4) edition of Dental Research, please send the information to lwedel1@uthsc.edu. If the news or information is about someone other than you, please obtain permission from that person(s) before submitting it. Your submission will be reviewed and assessed for appropriateness to be included in this newsletter. If you find any errors in Dental Research, also send those comments to lwedel1@uthsc.edu. Corrections will be placed in the following edition of Dental Research. For news and notices that are updated weekly, please visit: www.uthsc.edu/dentistry/Research/news.php. Thank you.

Awards Honors

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The UTHSC College of Dentistry was founded in 1878 making it the oldest dental college in the South, and the third oldest public college of dentistry in the United States.

The College contains a 4-year dental program, totaling approximately 320 students. In addition, students in the Postgraduate dental programs and Dental Hygiene are included.

The College is dedicated to providing professional, graduate, and postgraduate education; conducting dental research; and, delivering state-of-the-art patient care and public service.

ABOUT the COLLEGE of DENTISTRY

FOR MORE INFORMATION ABOUT THE UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER, VISIT: www.uthsc.edu

The University of Tennessee is an EEO/AA/Title VI/Title IX/Section 504/ADA/ADEA institution in the provision of its education and employment programs and services.

College of Dentistry 875 Union Avenue

Memphis, TN 38163 Phone: (901) 448-6200

Fax: (901) 448-1625