Delivering clinical research to make patients, and the NHS, better

NIHR CRN: North Thames

Prof Lyn Chitty – Clinical Director

NIHR Landscape

Clinical Research Network

Provide research support in clinical teams to facilitate recruitment to portfolio studies

Research nursesData managersVariety of other posts

Develop systems to identify and recruit participants

CSP – gaining NHS permissions for research studies

PERFORMANCE MANAGEMENT of DELIVERY

Launch of National Cancer Research

Network

Creation of Mental Health Research

Network

UKCRN established along with four

additional Research Networks, making up the 6 therapy areas recognised today

National Institute for Health Research created to implement Government

Health Strategy “Best Research for Best Health”

Primary Care and Comprehensive

Research Networks created

NIHR CRN is formed to deliver clinical research

in England

2001 2003 2006/7 20092005 2010

Dr Jonathan Sheffield joins NIHR CRN as

Chief Executive OfficerHigh Level Objectives

and Performance Management

Framework introduced

2012

Health and Social Care Act comes into effect bringing new

NHS structures

2012 - 15

Time for the National Institute

for Health Research Clinical Research Network

to evolve

Our journey so far…

2007/8 2008/9 2009/10 2010/11 2011/12 2012/130

100,000

200,000

300,000

400,000

500,000

600,000

700,000

208,200

331,226

454,138

564,698

595,540637,974

Patients recruited

We have tripled the annual number of patients into studies in six years

Ensure patients will benefit from a consistent approach to clinical research with key specialties being available in all geographies

Provide transparent, consistent governance and clear accountability

Ensure funders (including industry) will benefit from a consistent integrated approach to research delivery

Be platform to share best practice in research delivery and improve learning opportunities and career development

A simplified structure will

High Level Objectives

1. Increase the number of participants recruited into NIHR CRN Portfolio studies

Number of participants recruited in a reporting year into NIHR CRN Portfolio studies

650,000

2. Increase the proportion of studies in the NIHR CRN Portfolio delivering to recruitment target and time

A: Proportion of commercial contract studies achieving or surpassing their recruitment target during their planned recruitment period, at confirmed Network sites

80%

B: Proportion of non-commercial studies achieving or surpassing their recruitment target during their planned recruitment period

80%

3. Increase the number of commercial contract studies delivered through the NIHR CRN

A: Number of new commercial contract studies entering the NIHR CRN Portfolio

600

B: Number of new commercial contract studies entering the NIHR CRN Portfolio as a percentage of the total commercial MHRA CTA approvals for Phase II–IV studies

75%

4. Reduce the time taken for NIHR studies to achieve NHS Permission through CSP

Proportion of studies obtaining NHS Permission at all sites within 40 calendar days (from receipt of a valid complete application by NIHR CRN)

80%

5. Reduce the time taken to recruit first participant into NIHR CRN Portfolio studies

A: Proportion of commercial contract studies achieving first participant recruited within 30 calendar days of NHS Permission being issued or First Network Site Initiation Visit, at confirmed Network sites

80%

B: Proportion of non-commercial studies achieving first participant recruited within 30 calendar days of NHS Permission being issued

80%

6. Increase NHS participation in NIHR CRN Portfolio Studies A: Proportion of NHS Trusts recruiting each year into NIHR CRN Portfolio studies

99%

B: Proportion of NHS Trusts recruiting each year into NIHR CRN Portfolio commercial contract studies

70%

C: Proportion of General Medical Practices recruiting each year into NIHR CRN Portfolio studies

25%

7. Increase the number of participants recruited into Dementias and Neurodegeneration (DeNDRoN) studies on the NIHR CRN Portfolio

Number of participants recruited into Dementias and Neurodegeneration (DeNDRoN) studies on the NIHR CRN Portfolio

13,500

CRN: North Thames

North Central London, Essex & HertsFormed by merging 11 networksHosted by Barts Health

17 Acute Trusts7 Community & Mental Health Trusts20 CCGs4 HEIs [2 medical schools]

Population 5.7M (10% NHS)Budget £29.4M (+£0.93M RCF)>10% of NIHR portfolio leadfrom North Thames

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London

Guildford

Maidstone

Basildon

High Wycombe

Slough

Reigate

Dartford

Watford

Dunstable Stevenage

Brentwood

Chelmsford

Chief Operating

Officer

Communications Officer & Office

Manager

Admin Officer

Head of RM&G

CSP Co-ordinator

2.0WTEPharmacy/Medical Exposure Manager

Permissions Centre Co-

ordinator

1.0WTE per centre

Head of Finance & Information

Information

Systems Officer

Finance & Information

Manager

Finance OfficerPerformance

Reporting Officer

Industry Operations

Manager

Research Delivery Manager 6.0WTE

Deputy Delivery Manager 6.0WTE

Admin Officer

3.0WTE

Divisional Portfolio Officer 12.0 WTE

Clinical Director

Industry Co-ordinator

PCPIE Manager

Pharmacy /Medical Exposure Co-

ordinator

NIHR CRN Co-ordinating Centre

Barts Health NHS Trust Board

CRN: North Thames Partnership Group

CRN: North Thames Executive Group

CRN: North Thames

Operational Management Group

CRN: North Thames

R&D Advisory Group

CRN: North Thames

Clinical Leadership Group

1

CRN: North Thames Governance Structure

Divisional structureDIVISIONS

Division 1 Speciality Leads for 5 different tumour groups

Division 2 Diabetes & metabolic and endocrine disorders, stroke, cardiovascular disease, renal disorders

Division 3 Children, genetics, haematology, reproductive health and childbirth

Division 4Dementias and neurodegeneration, mental health,

neurological disorders

Division 5Primary Care & ageing, oral and dental health, health services and research delivery & public health, musculoskeletal, dermatology

Division 6Anaesthesia/peri-operative medicine, pain management & critical

care, injuries/emergencies, surgery, ENT, infectious diseases/microbiology, ophthalmology, respiratory disorders,

gastroenterology, hepatology, interventional radiology

The studies and the people

Div 1 Div 2 DIV 3 Div 4 Div 5 Div 6

Open studies 228 128 144 154 131 222

(commercial) (47) (23) (29) (24) (24) (56)

Workforce (FTE) 114.5 59 66 83 52 61

Recruitment (2012-13)

5023 10507 9007 9573 10422 8755

Interventional 2392 1631 2927 2236 4141 1271

Recruitment CRN: NT

2012/13 58,6752013/14 54,5102014/15 64,939 (target ~58,000)

CCG Recruitment 2013/14 vs 2014/15

Total0

2000

4000

6000

8000

10000

1200011205

10011

2013/14 2014/15

Recruitment by CCG 2013/14 vs. 2014/15

NHS Barking and Dagenham CCG

NHS Barnet CCG

NHS Basildon and Brentwood CCG

NHS Camden CCG

NHS Castle Point and Rochford CCG

NHS City and Hackney CCG

NHS Enfield CCG

NHS Haringey CCG

NHS Havering CCG

NHS Herts Valleys CCG

NHS Islington CCG

NHS Luton CCG

NHS Mid Essex CCG

NHS Newham

CCG

NHS Redbridge CCG

NHS Southend CCG

NHS Thurrock CCG

NHS Tower Ham

lets CCG

NHS Waltham

Forest CCG

NHS West Essex CCG

0

500

1000

1500

2000

2500

3000

2013/14 2014/15

CCG Recruitment by Specialty 2014/15

Primary Care

Infectious diseases and microbiology

Cardiovascular disease

Diabetes

Children

Health services and delivery research

Mental Health

Reproductive health and childbirth

Oral and dental health

Cancer

Stroke

Dementias and neurodegeneration

Renal disorders

Ageing

Respiratory disorders

Metabolic and endocrine disorders

Neurological disorders

0

1000

2000

3000

4000

50005049

2004

12541107

27757 57 44 35 32 32 23 17 10 10 2 1

No. GP Practices by CCG

Barking &

Dagenham

Barnet

Basildon &

Brentw

ood

Camden

Castle Point &

Rochford

City an

d Hackney

Enfield

Haringe

y

Haverin

g

Herts Vall

ey

Islingto

n

Luto

n

Mid Esse

x

Newham

Redbridge

South

end

Thurro

ck

Tower H

amlets

Walt

ham Fo

rest

West

Essex C

CG 0

10

20

30

40

50

60

70

80

Active GP Practices by CCG 2014/15

Barking &

Dagenham

Barnet

Basildon &

Brentwood

Camden

Castle Point &

Rochford

City and Hackn

ey

Enfield

Haringey

Haverin

g

Herts Valle

y

Islington

Luton

Mid Essex

Newham

Redbridge

Southend

Thurrock

Tower Hamlets

Walth

am Forest

West

Essex

0%

10%

20%

30%

40%

50%

60%

70%

80%

90%

100%

66 5

10

13

31

85

8

1812 10

30

21

1211

12

16

6

15

3464 39

30

15

14

4445

42

4926 21

18

40

3425

22

20

39

23

2015-16

£30M + £1M RCF

Initially based on workforce pre-April

Creating a flexible workforce

Divisions build business cases with TrustsTo replace departing staffTo fund new positions

Resource allocation model to support current and new workload (not rewarding past activity) but appropriate to needs

Total recruitment target for NIHR ~58,000. We have set local targets with trusts but need to be aiming high (65,000 = 10% of the NHS)

RM&G Changes

National focus on study support service

HRA

Local provision changes

Harmonisation roll-out across entire CRN

CRN-wide coordination

Working in the CRN

Develop career pathwaysWorkforce reviewStandardised/Job Titles JDsDeveloping a graduate training scheme

Flexible working

Induction

Training and GCP

Dissemination events

Divisional Contacts

Clinical Research Lead Research Delivery Manager (Deputy)

Division 1 Adele Fielding/David Chao Dawn Beaumont-JewellAderonke Adebiyi(Jennifer Godwin)

Division 2 David Wheeler Phil Smith(Jill Gallagher)

Division 3 William Van’t Hoff Dawn Beaumont-Jewell(Heidi Chandler)

Division 4 Helen Killaspy Tania Page(Sarah Styles)

Division 5 David Isenbeg/Lynis Lewis Aderonke Adebiyi(Christine Menzies)

Division 6 Margaret Johnson Sharon Barrett(Belinda Theis)

Contact Us

Email and phone contacts:

crnnorththames@nihr.ac.uk 

Office base for core team:

4th Floor,

170 Tottenham Court Rd

London W1T 7HA

http://www.crn.nihr.ac.uk/

Follow us on Twitter @NIHRCRN_nthames