date: 20/03/16 report on qip course: biology for engineers ...1).pdf · report on qip course:...
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G.H.RAISONI COLLEGE OF ENGINNERING, NAGPUR (An autonomous institute affiliated by RTMNU under UGC Act 1956)
Programmes Accreditated by National Board of Accreditation Accreditated by NAAC with “A Grade”
DEPARTMENT OF ELECTRONICS ENGINNERING
1 | P a g e Q I P C o u r s e : B i o l o g y f o r E n g i n e e r : J u n e 6 - 1 1 2 0 1 6
Date: 20/03/16
Report on
QIP Course: Biology for Engineers IIT Bombay –June 6-11 2016
Course Module: Monday 6th June 2016 8:30 am to Saturday 11th June 2016 4:30 pm. Course Coordinator: Dr. Ambarish Kunwar, Bioscience & Bioinformatics Department, IIT Bombay. Course Venue: Vanvihar Guest House Seminar Hall, IIT Bombay.
G.H.RAISONI COLLEGE OF ENGINNERING, NAGPUR (An autonomous institute affiliated by RTMNU under UGC Act 1956)
Programmes Accreditated by National Board of Accreditation Accreditated by NAAC with “A Grade”
DEPARTMENT OF ELECTRONICS ENGINNERING
2 | P a g e Q I P C o u r s e : B i o l o g y f o r E n g i n e e r : J u n e 6 - 1 1 2 0 1 6
Day 1 : 6th June 2016
Registration report time: 8:30 to 9am Inauguration: 9am to 9:30 am Lecture 1 Module: Prof. Ambarish Kunwar (10-11:30am) Topic: Forces at microscopic scale in biology
Focus points:
Molecular Motors for transportation. Swimming of Bacteria with microscopic world Protein performs their function by folding 20 Amino acids –proteins making Protein mass measure in Dalton ie. 100KDa 1Da=1Hydrogene New concept for Biology Dashpot Problem Solving on protein Engineering Forces action on Protein molecule. Motion of mechanical element Motion of combination of Mechanical element Motion of combination of mechanical elements Mass and spring with Damping
G.H.RAISONI COLLEGE OF ENGINNERING, NAGPUR (An autonomous institute affiliated by RTMNU under UGC Act 1956)
Programmes Accreditated by National Board of Accreditation Accreditated by NAAC with “A Grade”
DEPARTMENT OF ELECTRONICS ENGINNERING
3 | P a g e Q I P C o u r s e : B i o l o g y f o r E n g i n e e r : J u n e 6 - 1 1 2 0 1 6
Lecture 2 Module: Prof. Ambarish Kunwar (11:30am to 1pm) Topic: Thermal and viscous Forces in Biology (Biophysics)
Focus points:
Effect of Medium on Biological System Viscosity and fluid flow Viscous critical force Calculation for Reynolds number Life at low Reynolds number Reynolds Derivation
Lecture 2 Module: Prof. Debashish Chowdhury, IIT Kanpur (2:30pm to 4pm) Topic: Thermal Energy and Brownian Motion
Focus points: Ficks Law + Eqn of Continuity = Diffision Eqn. Fundamental principle : Over damped Motion Dominant forces Einstein Relation Beyond Diffusion: Directed (noisy) Transport Molecular Motor Examples of Molecular motors
G.H.RAISONI COLLEGE OF ENGINNERING, NAGPUR (An autonomous institute affiliated by RTMNU under UGC Act 1956)
Programmes Accreditated by National Board of Accreditation Accreditated by NAAC with “A Grade”
DEPARTMENT OF ELECTRONICS ENGINNERING
4 | P a g e Q I P C o u r s e : B i o l o g y f o r E n g i n e e r : J u n e 6 - 1 1 2 0 1 6
Ion motive Force an electro chemical gradient
Fundamental principle : Thermally activated Barrier hopping
Feynmamns Rotary ratchet and pawl device
A Brownian moter does not violate 2nd law of thermodynamics as it operates
far from equilibrium where the 2nd law is not applicable.
Rotary Brownian rachet
www.biologie.uni-
osnabrueck.de/biophys/junge/picture/ATPasevideo/synthase.Mov
G.H.RAISONI COLLEGE OF ENGINNERING, NAGPUR (An autonomous institute affiliated by RTMNU under UGC Act 1956)
Programmes Accreditated by National Board of Accreditation Accreditated by NAAC with “A Grade”
DEPARTMENT OF ELECTRONICS ENGINNERING
5 | P a g e Q I P C o u r s e : B i o l o g y f o r E n g i n e e r : J u n e 6 - 1 1 2 0 1 6
Day 2 : 7th June 2016
Lecture 1 Module: Prof. Kiran Kondabagil (9:30am-11am) Topic: Introduction to cell and cellular process
Evolution and Biology of Extremely Large DNA Viruses Are they alive ? Why are they so big? How do they invade the host? How do they manage to stuff their genome inside the capsid?
Introduction to Cell and Cellular process Characteristics of life
G.H.RAISONI COLLEGE OF ENGINNERING, NAGPUR (An autonomous institute affiliated by RTMNU under UGC Act 1956)
Programmes Accreditated by National Board of Accreditation Accreditated by NAAC with “A Grade”
DEPARTMENT OF ELECTRONICS ENGINNERING
6 | P a g e Q I P C o u r s e : B i o l o g y f o r E n g i n e e r : J u n e 6 - 1 1 2 0 1 6
Lecture 2 Module: Prof. Kiran Kondabagil (11:30am-1pm) Topic: Evolution, genetic and chromosomes
Darwin Presented evidence that the today’s organisms are descendants of ancestral species
Darwin proposed a mechanisms for evolutionary process : natural selection Essential for the progress of biology Evolutionary concepts are major part of moderns biology experiments Study of virus evolution (influenza/HIV/H1N1) cancer progression, bacterial drug
resistance etc can save thousands of lives
G.H.RAISONI COLLEGE OF ENGINNERING, NAGPUR (An autonomous institute affiliated by RTMNU under UGC Act 1956)
Programmes Accreditated by National Board of Accreditation Accreditated by NAAC with “A Grade”
DEPARTMENT OF ELECTRONICS ENGINNERING
7 | P a g e Q I P C o u r s e : B i o l o g y f o r E n g i n e e r : J u n e 6 - 1 1 2 0 1 6
Lecture 3 Module: Prof. Rahul Purwar (2:30pm-4pm) Topic: Basic Biology of bacteria
Bacteriophages Some virus has envelopes which are membranous convering derived from the
membrane of the host cell. CD4 + T cells –only cell which is infected by HIV in Humans
G.H.RAISONI COLLEGE OF ENGINNERING, NAGPUR (An autonomous institute affiliated by RTMNU under UGC Act 1956)
Programmes Accreditated by National Board of Accreditation Accreditated by NAAC with “A Grade”
DEPARTMENT OF ELECTRONICS ENGINNERING
8 | P a g e Q I P C o u r s e : B i o l o g y f o r E n g i n e e r : J u n e 6 - 1 1 2 0 1 6
Lecture 4 Module: Prof. Rahul Purwar (4:30pm-6pm) Topic: Virus Basic Understanding and relevance in medicine
Adoptive T cell therapy: Engineered CAR-T cells
Review of recent clinical trials
Challenges of CAR T cell therapy
Results
T cell subsets: Th17 and Th9 cells in cancer immunotherapy
Target therapy with Tumor specific T cells
Cancer: Melanoma
Autologous tumor infiltrating lymphocytes (TILs); “Live drug”
Advantages
High response rate (>50%),
Long-term remission,
Less toxic & gentler to the patient
Limitation:
Extraction of TILs,
Cell manufacturing
Possible alternate
T cell Engineering (CAR-T cells)
G.H.RAISONI COLLEGE OF ENGINNERING, NAGPUR (An autonomous institute affiliated by RTMNU under UGC Act 1956)
Programmes Accreditated by National Board of Accreditation Accreditated by NAAC with “A Grade”
DEPARTMENT OF ELECTRONICS ENGINNERING
9 | P a g e Q I P C o u r s e : B i o l o g y f o r E n g i n e e r : J u n e 6 - 1 1 2 0 1 6
Day 3 : 8th June 2016
Lecture 5 Module: Prof. Ranjith Padinhateeri (9:30am-11am) Topic: Thermal Bending of Biofillaments
DAN packaging
G.H.RAISONI COLLEGE OF ENGINNERING, NAGPUR (An autonomous institute affiliated by RTMNU under UGC Act 1956)
Programmes Accreditated by National Board of Accreditation Accreditated by NAAC with “A Grade”
DEPARTMENT OF ELECTRONICS ENGINNERING
10 | P a g e Q I P C o u r s e : B i o l o g y f o r E n g i n e e r : J u n e 6 - 1 1 2 0 1 6
Energy required to bend DNA
G.H.RAISONI COLLEGE OF ENGINNERING, NAGPUR (An autonomous institute affiliated by RTMNU under UGC Act 1956)
Programmes Accreditated by National Board of Accreditation Accreditated by NAAC with “A Grade”
DEPARTMENT OF ELECTRONICS ENGINNERING
11 | P a g e Q I P C o u r s e : B i o l o g y f o r E n g i n e e r : J u n e 6 - 1 1 2 0 1 6
Lecture 6 Module: Prof. Kiran Kondabagil (11:30am-1pm) Topic: From Genes to Protein
Genotype: An organism full hereditary information Phenotype: actual observed properties Genetics of intelligence Genetics and chromosomes Flow of heritable traits
Phenotypic characters that are passed on from parent to offspring E.g. eye and hair color * imagine a future where a test predicts whether you will get cancer. * Today, Uzbekistan is using genetic testing to find future Olympians
Tutorial 1: Prof. Dulal Panda (2:30 pm -4 pm) Topic: Fluorescence spectroscopy, circular Dichroism and FASC in biology
Advantages of Fluorescence Spectroscopy
1. High level of sensitivity and wide dynamic range
2. Single molecule detection
3. Instrument is convenient and modest cost
G.H.RAISONI COLLEGE OF ENGINNERING, NAGPUR (An autonomous institute affiliated by RTMNU under UGC Act 1956)
Programmes Accreditated by National Board of Accreditation Accreditated by NAAC with “A Grade”
DEPARTMENT OF ELECTRONICS ENGINNERING
12 | P a g e Q I P C o u r s e : B i o l o g y f o r E n g i n e e r : J u n e 6 - 1 1 2 0 1 6
Spectroscopy is a general term referring to the interactions of various types of electromagnetic radiation with matter. Exactly how the radiation interacts with matter is directly dependent on the energy of the radiation. Spectroscopy: Is an analytical method technique wherein the absorbance of specific wavelength of light by the molecules of sample under test is determined. The more the number of molecules in sample, the greater is the absorbance and vice-verse.
Spectroscopy The higher energy ultraviolet and visible wavelengths affect the energy levels of the outer electrons. Radio waves are used in nuclear magnetic Resonance and affect the spin of nuclei in a magnetic field. Infrared radiation is absorbed by matter resulting in rotation and/or vibration of molecules.
Fluorescence Activated Cell Sorter Machine : FACS
G.H.RAISONI COLLEGE OF ENGINNERING, NAGPUR (An autonomous institute affiliated by RTMNU under UGC Act 1956)
Programmes Accreditated by National Board of Accreditation Accreditated by NAAC with “A Grade”
DEPARTMENT OF ELECTRONICS ENGINNERING
13 | P a g e Q I P C o u r s e : B i o l o g y f o r E n g i n e e r : J u n e 6 - 1 1 2 0 1 6
Day 4 : 9th June 2016
Lecture 7 Module: Prof. Rahul Purwar(9:30am-11am) Topic: Stem cells: Basics Science to Medicine
Antibody “Her2” is used to treat cancer
Stem cells are undifferentiated biological cells that can differentiate into specialized cells and
can divide (through mitosis) to produce more stem cells. They are found in
multicellular organisms. In mammals, there are two broad types of stem cells: embryonic stem
cells, which are isolated from the inner cell mass of blastocysts, and adult stem cells, which are
found in various tissues. In adultorganisms, stem cells and progenitor cells act as a repair system
for the body, replenishing adult tissues. In a developing embryo, stem cells can differentiate into
all the specialized cells—ectoderm, endoderm and mesoderm (see induced pluripotent stem
cells)—but also maintain the normal turnover of regenerative organs, such as blood, skin, or
intestinal tissues.
There are three known accessible sources of autologous adult stem cells in humans:
1. Bone marrow, which requires extraction by harvesting, that is, drilling into bone (typically
the femur or iliac crest).
2. Adipose tissue (lipid cells), which requires extraction by liposuction.
3. Blood, which requires extraction through apheresis, wherein blood is drawn from the
donor (similar to a blood donation), and passed through a machine that extracts the stem
cells and returns other portions of the blood to the donor.
G.H.RAISONI COLLEGE OF ENGINNERING, NAGPUR (An autonomous institute affiliated by RTMNU under UGC Act 1956)
Programmes Accreditated by National Board of Accreditation Accreditated by NAAC with “A Grade”
DEPARTMENT OF ELECTRONICS ENGINNERING
14 | P a g e Q I P C o u r s e : B i o l o g y f o r E n g i n e e r : J u n e 6 - 1 1 2 0 1 6
Lecture 8 Module: Prof. Rahul Purwar (11:30am-1pm) Topic: Stem cells: Cell signaling how do cell communicate
Cell use chemical signals for communication Local signaling : the signal acts on nearby cells In a multi cellular organisms : two types of signaling pathways In single cells: three stages of cell signaling Two types of signaling pathways in multicellular organism Signal –receiver (Receptor)
Most of the receptor is plasma membrane proteins for the recognition of ligands: 1. G- protein coupled receptor 2. Receptor tyrosine kinases 3. Ion-channel receptor
G.H.RAISONI COLLEGE OF ENGINNERING, NAGPUR (An autonomous institute affiliated by RTMNU under UGC Act 1956)
Programmes Accreditated by National Board of Accreditation Accreditated by NAAC with “A Grade”
DEPARTMENT OF ELECTRONICS ENGINNERING
15 | P a g e Q I P C o u r s e : B i o l o g y f o r E n g i n e e r : J u n e 6 - 1 1 2 0 1 6
Bio Engineering Model
Lecture 9: Module: Prof. Rohit Srivastava (2:30am-4pm) Topic: Stem cells: Introduction to Biomedical Engineering Biomedical Engineering (BME) • Definition2: The use of engineering technology, instrumentation and methods to solve medical problems, such as improving our understanding of physiology and the manufacture of artificial limbs and organs. Diversity in the terminology • (bio)medical engineering, • bioengineering, biotechnology • clinical (medical) engineering • medical technology. • health care technology
G.H.RAISONI COLLEGE OF ENGINNERING, NAGPUR (An autonomous institute affiliated by RTMNU under UGC Act 1956)
Programmes Accreditated by National Board of Accreditation Accreditated by NAAC with “A Grade”
DEPARTMENT OF ELECTRONICS ENGINNERING
16 | P a g e Q I P C o u r s e : B i o l o g y f o r E n g i n e e r : J u n e 6 - 1 1 2 0 1 6
Application of BME
Artificial heart (20.4 month recoed) Artificial Kidney (not design yet) Dialysis machine Mems Design Artificial insule pain Artificial urinary bladder Artificial Hips Joint replacement (titanium alloy) Bionic Arm *Mr. Robert Langer –1000 Patent (Chemical Engienner)
In View of Electronics Engineering
In view of Mechanical Engineering
G.H.RAISONI COLLEGE OF ENGINNERING, NAGPUR (An autonomous institute affiliated by RTMNU under UGC Act 1956)
Programmes Accreditated by National Board of Accreditation Accreditated by NAAC with “A Grade”
DEPARTMENT OF ELECTRONICS ENGINNERING
17 | P a g e Q I P C o u r s e : B i o l o g y f o r E n g i n e e r : J u n e 6 - 1 1 2 0 1 6
Lecture 10: Module: Prof. P.V.Balaji (4:30am-6pm) Topic: Stem cells: Proteon Structure – Free Energy and Entropy and their role
Protein performs their function by folding into different shapes 20-Aminoa acids
Entropy S =K g ln W Where, W= no of microscopic arrangement
Two macro & micro state of a folded state Probability of a folding a protein a micro or Macro state
G.H.RAISONI COLLEGE OF ENGINNERING, NAGPUR (An autonomous institute affiliated by RTMNU under UGC Act 1956)
Programmes Accreditated by National Board of Accreditation Accreditated by NAAC with “A Grade”
DEPARTMENT OF ELECTRONICS ENGINNERING
18 | P a g e Q I P C o u r s e : B i o l o g y f o r E n g i n e e r : J u n e 6 - 1 1 2 0 1 6
Protein Folding
G.H.RAISONI COLLEGE OF ENGINNERING, NAGPUR (An autonomous institute affiliated by RTMNU under UGC Act 1956)
Programmes Accreditated by National Board of Accreditation Accreditated by NAAC with “A Grade”
DEPARTMENT OF ELECTRONICS ENGINNERING
19 | P a g e Q I P C o u r s e : B i o l o g y f o r E n g i n e e r : J u n e 6 - 1 1 2 0 1 6
Day 5 : 10th June 2016
Lecture 11 Module: Prof. Soumyo Mukherji (9:30am-11am) Topic: Electrophysiology
Heart beats rate -72 per minute Per day= 103680 almost 1 lack Per year = 37843200 about 3.75 cores Over a life time = 245 cores (in about 65 year)
G.H.RAISONI COLLEGE OF ENGINNERING, NAGPUR (An autonomous institute affiliated by RTMNU under UGC Act 1956)
Programmes Accreditated by National Board of Accreditation Accreditated by NAAC with “A Grade”
DEPARTMENT OF ELECTRONICS ENGINNERING
20 | P a g e Q I P C o u r s e : B i o l o g y f o r E n g i n e e r : J u n e 6 - 1 1 2 0 1 6
G.H.RAISONI COLLEGE OF ENGINNERING, NAGPUR (An autonomous institute affiliated by RTMNU under UGC Act 1956)
Programmes Accreditated by National Board of Accreditation Accreditated by NAAC with “A Grade”
DEPARTMENT OF ELECTRONICS ENGINNERING
21 | P a g e Q I P C o u r s e : B i o l o g y f o r E n g i n e e r : J u n e 6 - 1 1 2 0 1 6
Lecture 12 Module: Prof. Prakriti Tayalia (11:30am-1pm) Topic: Tissue Engineering
G.H.RAISONI COLLEGE OF ENGINNERING, NAGPUR (An autonomous institute affiliated by RTMNU under UGC Act 1956)
Programmes Accreditated by National Board of Accreditation Accreditated by NAAC with “A Grade”
DEPARTMENT OF ELECTRONICS ENGINNERING
22 | P a g e Q I P C o u r s e : B i o l o g y f o r E n g i n e e r : J u n e 6 - 1 1 2 0 1 6
G.H.RAISONI COLLEGE OF ENGINNERING, NAGPUR (An autonomous institute affiliated by RTMNU under UGC Act 1956)
Programmes Accreditated by National Board of Accreditation Accreditated by NAAC with “A Grade”
DEPARTMENT OF ELECTRONICS ENGINNERING
23 | P a g e Q I P C o u r s e : B i o l o g y f o r E n g i n e e r : J u n e 6 - 1 1 2 0 1 6
Lecture 13 Module: Prof. Neeta Kanekar (2:30pm-4pm) Topic: Movement Science and Rehabilitation Engineering
G.H.RAISONI COLLEGE OF ENGINNERING, NAGPUR (An autonomous institute affiliated by RTMNU under UGC Act 1956)
Programmes Accreditated by National Board of Accreditation Accreditated by NAAC with “A Grade”
DEPARTMENT OF ELECTRONICS ENGINNERING
24 | P a g e Q I P C o u r s e : B i o l o g y f o r E n g i n e e r : J u n e 6 - 1 1 2 0 1 6
G.H.RAISONI COLLEGE OF ENGINNERING, NAGPUR (An autonomous institute affiliated by RTMNU under UGC Act 1956)
Programmes Accreditated by National Board of Accreditation Accreditated by NAAC with “A Grade”
DEPARTMENT OF ELECTRONICS ENGINNERING
25 | P a g e Q I P C o u r s e : B i o l o g y f o r E n g i n e e r : J u n e 6 - 1 1 2 0 1 6
Tutorial Lecture 14 Module: Prof. Dulal Panda (4:30pm-6pm) Topic: Fluorescence Specroscopy, Circular Dichroism and FACS in Biology – Part- II
Dependence of Fluorescence Polarization on Molecular Mobility
(1/P -1/3) = (1/P0 -1/3) (1 + τ/Ø)
G.H.RAISONI COLLEGE OF ENGINNERING, NAGPUR (An autonomous institute affiliated by RTMNU under UGC Act 1956)
Programmes Accreditated by National Board of Accreditation Accreditated by NAAC with “A Grade”
DEPARTMENT OF ELECTRONICS ENGINNERING
26 | P a g e Q I P C o u r s e : B i o l o g y f o r E n g i n e e r : J u n e 6 - 1 1 2 0 1 6
Day 6 : 11th June 2016
Lecture 15 Module: Prof. (Dr.) V.P.Soni (9:30am-11am) Topic: Bioengineering concepts in Maxillo-facial Surgery
Engineering principles in surgical reconstruction Poly lactic polyalglamotate is the biodegradable
material used CAD-CAM Technology used to design Computer Assisted Surgery Gama Radiation used to Sterilize polymer graft for
body
G.H.RAISONI COLLEGE OF ENGINNERING, NAGPUR (An autonomous institute affiliated by RTMNU under UGC Act 1956)
Programmes Accreditated by National Board of Accreditation Accreditated by NAAC with “A Grade”
DEPARTMENT OF ELECTRONICS ENGINNERING
27 | P a g e Q I P C o u r s e : B i o l o g y f o r E n g i n e e r : J u n e 6 - 1 1 2 0 1 6
Lecture 16 Module: Prof. Ranjith Pandinhateeri (11:30am-1pm) Topic: Tutorial –II (Problem Solving)
Day 6 : 11th June 2016 : Valedictory Function and Certificate Distribution
G.H.RAISONI COLLEGE OF ENGINNERING, NAGPUR (An autonomous institute affiliated by RTMNU under UGC Act 1956)
Programmes Accreditated by National Board of Accreditation Accreditated by NAAC with “A Grade”
DEPARTMENT OF ELECTRONICS ENGINNERING
28 | P a g e Q I P C o u r s e : B i o l o g y f o r E n g i n e e r : J u n e 6 - 1 1 2 0 1 6
Biology + Engineering = Good idea*