Current Trainees (all email addresses end in partners.org)

John Albin, MD, PhD

Year Entered: 2014 Fellowship Interests: Infectious Diseases Email: jalbin I grew up in Nebraska and completed a BA in microbiology and Spanish at the University of Kansas. I then joined the University of Minnesota's MD-PhD program, where my thesis research focused on HIV molecular virology and host cell restriction factors. Beyond residency, I plan to complete a fellowship in infectious diseases with the ultimate goal of establishing a career combining basic

retrovirology and retroviral eradication strategies with the care of chronically infected patients. When not absorbed in these endeavors, I enjoy reading something unrelated to science/medicine and playing double bass. Selected Publications: Bohn MF*, Shandilya SM*, Albin JS, Kouno T, Anderson BD, McDougle RM, Carpenter MA, Rathore A,

Evans L, Davis AN, Zhang J, Lu Y, Somasundaran M, Matsuo H, Harris RS, Schiffer CA. Crystal structure of

the DNA cytosine deaminase APOBEC3F: the catalytically active and HIV-1 Vif-binding domain. Structure.

2013 Jun 4; 21(6):1042-50.

View in: PubMed

Albin JS, Anderson JS, Johnson JR, Harjes E, Matsuo H, Krogan NJ, Harris RS. Dispersed sites of HIV Vif-

dependent polyubiquitination in the DNA deaminase APOBEC3F. J Mol Biol. 2013 Apr 12; 425(7):1172-

82.

View in: PubMed

Albin JS, LaRue RS, Weaver JA, Brown WL, Shindo K, Harjes E, Matsuo H, Harris RS. A single amino acid in

human APOBEC3F alters susceptibility to HIV-1 Vif. J Biol Chem. 2010 Dec 24; 285(52):40785-92.

View in: PubMed

Pierre Ankomah, MD, PhD

Year Entered: 2015 Fellowship Interests: Infectious Diseases Email: pankomah I was born in Ghana, and grew up wanting to be, at various times, an economist, yam farmer, sports journalist and marine biologist, the latter slightly complicated by the fact that I couldn’t (and still can’t) swim. Upon realizing that a liberal arts education would be tolerant of my indecision, I moved to the Amish wonderland of Lancaster, PA to study at Franklin & Marshall College. Afterwards, I sought

warmer pastures in Atlanta, where I did an MD/PhD at Emory, exploring the pharmacodynamics of antibiotic combinations and resulting effects on infection clearance and evolution of resistance. I braved the trek to the Boston cold partly to keep my warm-cold-warm-cold transitions consistent, but also because I really want to figure out how one looks fashionable in snowshoes. I often jokingly say that am a professional soccer fan whose career has been blighted by occasional forays into science and medicine; if you can tolerate my animation while watching games, you may be rewarded by some Ghanaian cooking. Selected Publications: Ankomah P, Levin BR. Exploring the collaboration between antibiotics and the immune response in the

treatment of acute, self-limiting infections. Proc Natl Acad Sci U S A. 2014 Jun 10; 111(23):8331-8.

View in: PubMed

Ankomah P, Johnson PJ, Levin BR. The pharmaco -, population and evolutionary dynamics of multi-drug

therapy: experiments with S. aureus and E. coli and computer simulations. PLoS Pathog. 2013;

9(4):e1003300.

View in: PubMed

Ankomah P, Levin BR. Two-drug antimicrobial chemotherapy: a mathematical model and experiments

with Mycobacterium marinum. PLoS Pathog. 2012; 8(1):e1002487.

View in: PubMed

Allison Betof, MD, PhD

Year Entered: 2013 Fellowship Interests: Hematology / Oncology Email: abetof Originally from Philadelphia, PA, I graduated from Cornell University in 2005 with a Bachelor of Arts in Biology and the College Scholar Program. While at Cornell, I was also a varsity gymnast and pursued biomechanics research. Subsequently, I completed my MD and PhD degrees at Duke University. My Doctoral research focused on the effects of aerobic exercise on tumor hypoxia and angiogenesis in

mouse models of breast cancer. I am thrilled to be joining the housestaff at MGH, and I plan to pursue an academic career in solid tumor oncology. In my spare time, I am an enthusiastic athlete (coaching and competing in Cross Fit. Selected Publications: Betof AS, Lascola CD, Weitzel D, Landon C, Scarbrough PM, Devi GR, Palmer G, Jones LW, Dewhirst MW.

Modulation of murine breast tumor vascularity, hypoxia and chemotherapeutic response by exercise. J

Natl Cancer Inst. 2015 May; 107(5).

View in: PubMed

Betof AS, Rabbani ZN, Hardee ME, Kim SJ, Broadwater G, Bentley RC, Snyder SA, Vujaskovic Z,

Oosterwijk E, Harris LN, Horton JK, Dewhirst MW, Blackwell KL. Carbonic anhydrase IX is a predictive

marker of doxorubicin resistance in early-stage breast cancer independent of HER2 and TOP2A

amplification. Br J Cancer. 2012 Feb 28; 106(5):916-22.

View in: PubMed

Kelly Burke, MD, PhD

Year Entered: 2014 Fellowship Interests: Hematology / Oncology Email: kburke18 I was adopted from South Korea and grew up outside of St. Paul, Minnesota. I attended Kenyon College and recently graduated from Johns Hopkins where I earned my MD/PhD. In my spare time, I love cooking, eating, exploring farmer's markets, long-distance running, and international travel. I'm also a fan of Scrabble and number or word puzzles.

Selected Publications: Burke KP, Munshaw S, Osburn WO, Levine J, Liu L, Sidney J, Sette A, Ray SC, Cox AL. Immunogenicity and

cross-reactivity of a representative ancestral sequence in hepatitis C virus infection. J Immunol. 2012

May 15; 188(10):5177-88.

View in: PubMed

Burke KP, Cox AL. Hepatitis C virus evasion of adaptive immune responses: a model for viral persistence.

Immunol Res. 2010 Jul; 47(1-3):216-27.

View in: PubMed

Raghu Chivukula, MD, PhD

Year Entered: 2014 Fellowship Interests: Pulmonary / Critical Care Email: rchivukula After growing up outside New York City and attending high school in Wichita, KS I

spent 12 years in Baltimore as an undergraduate, MD, and PhD student at Johns

Hopkins. My dissertation work focused on microRNA roles in oncogenic

transformation and tissue regeneration. I went on to complete an internship in

general surgery at the MGH before making the switch to internal medicine and a

science-focused career within pulmonary and critical care medicine. My core interests remain in

understanding how epithelia respond and renew after acute injury, and how failed or abortive

regeneration may alternatively promote fibrosis. Outside the hospital and the lab I enjoy spending time

with my fiancée and our 2 Italian Greyhounds, rock climbing, exploring the Boston food and cocktail

scene, and Law & Order reruns.

Selected Publications: Chivukula RR, Shi G, Acharya A, Mills EW, Zeitels LR, Anandam JL, Abdelnaby AA, Balch GC, Mansour JC,

Yopp AC, Maitra A, Mendell JT. An essential mesenchymal function for miR-143/145 in intestinal

epithelial regeneration. Cell. 2014 May 22; 157(5):1104-16.

View in: PubMed

Kent OA, Chivukula RR, Mullendore M, Wentzel EA, Feldmann G, Lee KH, Liu S, Leach SD, Maitra A,

Mendell JT. Repression of the miR-143/145 cluster by oncogenic Ras initiates a tumor-promoting feed-

forward pathway. Genes Dev. 2010 Dec 15; 24(24):2754-9.

View in: PubMed

Kota J, Chivukula RR, O'Donnell KA, Wentzel EA, Montgomery CL, Hwang HW, Chang TC, Vivekanandan

P, Torbenson M, Clark KR, Mendell JR, Mendell JT. Therapeutic microRNA delivery suppresses

tumorigenesis in a murine liver cancer model. Cell. 2009 Jun 12; 137(6):1005-17.

View in: PubMed

Jason Cooper, MD, PhD

Year Entered: 2013 Fellowship Interests: Hematology / Oncology Email: jpcooper

Selected Publications: Cooper JP, Hwang K, Singh H, Wang D, Reynolds CP, Curley RW Jr, Williams SC, Maurer BJ, Kang MH. Fenretinide metabolism in humans and mice: utilizing pharmacological modulation of its metabolic pathway to increase systemic exposure. Br J Pharmacol. 2011; 163(6):1263-75. View in: PubMed

Victor Fedorov, MD, PhD

Year Entered: 2015 Fellowship Interests: Hematology / Oncology, Endocrinology Email: vfedorov Victor was born in Moscow, Russia, but eventually landed below the Mason-Dixon line in Richmond, Va. High school was a blur of track meets, improv/stage theater, and an early punctuated descent into the scientific realm. Attending the University of Richmond, he fully explored all corners of a liberal arts education, while playing water polo, participating in a fraternity, and still descending deeper

into scientific nerd-dome. Missing a worldly metropolitan city, he completed the MD/PhD program at Cornell in NYC, with a PhD from MSKCC focused on T and stem cell cellular therapies. More importantly, he survived all the endless options NYC had to offer. During this time, Victor tried his hand at a few entrepreneurial ventures in health tech, but still only drives an old Saab. He loves all things outdoors (climbing, biking, hiking, and snow), indoors (theater, arts, and food (i.e.)), and most importantly good times with friends. He knows almost nothing about Boston, but is very excited to learn doctoring there. Selected Publications: Fedorov VD, Themeli M, Sadelain M. PD-1- and CTLA-4-based inhibitory chimeric antigen receptors

(iCARs) divert off-target immunotherapy responses. Sci Transl Med. 2013 Dec 11; 5(215):215ra172.

View in: PubMed

Julie Fiore, MD, PhD

Year Entered: 2015 Fellowship Interests: Undeclared Email: jlfiore Originally from Pittsburgh, I completed my undergraduate studies in Chemistry and German at the University of Pittsburgh. The lure of the mountains drew me westward for my graduate studies in Chemical Physics at the University of Colorado Boulder, where I investigated RNA folding. I then landed in Milwaukee for medical school at the Medical College of Wisconsin. I am now thrilled to

continue my journey in Medicine at MGH. In my free time, you may catch me doing long runs (especially on trails), snowboarding, “reading” (I love audible), and exploring the local selection of IPAs. Selected Publications: Fiore JL, Holmstrom ED, Fiegland LR, Hodak JH, Nesbitt DJ. The role of counterion valence and size in

GAAA tetraloop-receptor docking/undocking kinetics. J Mol Biol. 2012 Oct 19; 423(2):198-216.

View in: PubMed

Fiore JL, Holmstrom ED, Nesbitt DJ. Entropic origin of Mg2+-facilitated RNA folding. Proc Natl Acad Sci U

S A. 2012 Feb 21; 109(8):2902-7.

View in: PubMed

Michael Forrester, MD, PhD

Year Entered: 2013

Fellowship Interests: Cardiology Email: mtforrester Originally from Chicago, I completed my undergraduate degree at Northwestern

University where I studied synthetic organic chemistry and found my intellectual

home in the laboratory. Figuring an MD/PhD program would provide a nice

challenge, I next found myself at Duke for medical school and my thesis. The

latter focused on proteomics and assay development, with a particular emphasis on stress signaling and

nitric oxide biology. My brief postdoctoral work focused on protein lipid modifications where I further

expanded my expertise in proteomics and mass spectrometry. Selecting a residency was not a

particularly tough decision, as internal medicine was one of the few fields providing the degree of

intellectual breadth and physical intensity that I desired. Coming to MGH seemed a very natural decision

and unquestionably one of the finest opportunities of my life. Outside of medicine and science, my

hobbies include spending time with my wife and our two dogs, travelling around Maine, bass guitar and

postmodern literature such as Vonnegut and Hemingway

Selected Publications:

Forrester MT, Seth D, Hausladen A, Eyler CE, Foster MW, Matsumoto A, Benhar M, Marshall HE, Stamler

JS. Thioredoxin-interacting protein (Txnip) is a feedback regulator of S-nitrosylation. J Biol Chem. 2009

Dec 25; 284(52):36160-6.

View in: PubMed

Forrester MT, Thompson JW, Foster MW, Nogueira L, Moseley MA, Stamler JS. Proteomic analysis of S-

nitrosylation and denitrosylation by resin-assisted capture. Nat Biotechnol. 2009 Jun; 27(6):557-9.

View in: PubMed

David Gross, MD, PhD

Year Entered: 2014 Fellowship Interests: Cardiology Email: dgross3 I grew up in upstate NY in a town called Niskayuna, a small suburb of Albany. After undergrad at Stanford, I moved to NYC to complete my MD/PhD at Albert Einstein College of Medicine. In between defending my thesis and M3, I lived in Singapore for several months doing basic research as my mentor's lab moved there. Outside of work, I'm an avid skier and biker and love to travel.

Selected Publications: Gross DA, Silver DL. Cytosolic lipid droplets: from mechanisms of fat storage to disease. Crit Rev

Biochem Mol Biol. 2014 Jul-Aug; 49(4):304-26.

View in: PubMed

Gross DA, Zhan C, Silver DL. Direct binding of triglyceride to fat storage-inducing transmembrane

proteins 1 and 2 is important for lipid droplet formation. Proc Natl Acad Sci U S A. 2011 Dec 6;

108(49):19581-6.

View in: PubMed

Gross DA, Snapp EL, Silver DL. Structural insights into triglyceride storage mediated by fat storage-

inducing transmembrane (FIT) protein 2. PLoS One. 2010; 5(5):e10796.

View in: PubMed

Vikas Gupta, MD, PhD

Year Entered: 2014

Fellowship Interests: Gastroenterology Email: vgupta0 I was born in Washington, DC; however, I primarily grew up in Allentown, PA.

After attending Penn State University, I matriculated into the MD/PhD program at

Duke University. In Ken Poss’ lab, my graduate studies were focused upon a

multicolor clonal analysis of cardiomyocytes during zebra fish heart regeneration

and morphogenesis. Outside of science and medicine, I enjoy going to

restaurants, being outdoors, am an avid sports fan, movie buff, and love to workout!

Selected Publications:

Gupta VK, KD Poss. Clonally dominant cardiomyocytes direct heart morphogenesis. Nature. 2012;

484(7395):479-484.

View in: PubMed

Jessica Hennessey, MD, PhD

Year Entered: 2014 Fellowship Interests: Cardiology Email: jahennessey I am originally from Milford, Connecticut, which is right outside New Haven. I have two sisters and we are part of a large Italian family. With my family we have many Italian traditions centered around food for the holidays, especially Christmas and Easter. I went to NYU for undergrad, where I majored in biology and then moved

down to Durham for my MD/PhD. I am married to my husband, Tom, who is an attorney and a realtor. We love basketball (yes I am a Duke fan), which we play together often. I enjoy running and have run a fair amount of half marathons. Additionally, I greatly enjoy carrying on the traditions of my family with cooking and get-togethers! Selected Publications: Hennessey JA, Marcou CA, Wang C, Wei EQ, Wang C, Tester DJ, Torchio M, Dagradi F, Crotti L, Schwartz

PJ, Ackerman MJ, Pitt GS. FGF12 is a candidate Brugada syndrome locus. Heart Rhythm. 2013 Dec;

10(12):1886-94.

View in: PubMed

Hennessey JA, Wei EQ, Pitt GS. Fibroblast growth factor homologous factors modulate cardiac calcium

channels. Circ Res. 2013 Aug 2; 113(4):381-8.

View in: PubMed

Benjamin Herzberg, MD

Year Entered: 2015 Fellowship Interests: Hematology / Oncology Email: bherzberg I was born at Albert Einstein Hospital in the Bronx, raised in Westfield, New

Jersey, and attended high school at Solomon Schechter Day School. I received my

AB from Princeton University in Chemistry and Quantitative and Computational

Biology, where I studied cancer metabolomics with Joshua Rabinowitz and aging

in C. elegans with Coleen Murphy. I then took a brief interlude to get a degree in the History of Science

and Medicine at Imperial College, London, focusing on 20th-century organic chemistry and the career of

Robert Robinson, the 1947 Nobel Laureate in Chemistry. I then moved on to Harvard Medical School

and the Harvard-MIT Health Sciences and Technology program, where I spent my research time in the

laboratory of James Bradner. There I studied the mechanism of action of lenalidomide in multiple

myeloma and applied novel chemical techniques to drug target identification problems. I am broadly

interested in chemical biology, cancer, and genetics, and will be pursuing a fellowship in

hematology/oncology.

Selected Publications: Herzberg B, Gainor J. Immune checkpoint blockade in lung cancer. The Oncologist. 2015: in press Fluorous drug-affinity proteomics for cancer drug discovery. Thesis submitted to the HST program and

for Honors at HMS.

Metabolomic exploration of pyruvate kinase variants in yeast and cancer. Thesis in Chemistry and

Genomics at Princeton University. 2010.

Nikolaus Jilg, MD, PhD Year Entered: 2013 Fellowship Interests: Infectious Diseases Email: njilg Prior to residency at MGH, I trained in internal medicine in Germany and did a postdoctoral fellowship on innate immunity in hepatitis C. In my spare time, I enjoy soccer, hiking and skiing.

Selected Publications: Jilg N, Lin W, Hong J, Schaefer EA, Wolski D, Meixong J, Goto K, Brisac C, Chusri P, Fusco DN, Chevaliez S,

Luther J, Kumthip K, Urban TJ, Peng LF, Lauer GM, Chung RT. Kinetic differences in the induction of

interferon stimulated genes by interferon-α and interleukin 28B are altered by infection with hepatitis C

virus. Hepatology. 2014; 59(4):1250-61.

View in: PubMed Jilg N, Lin W, Hong J, Schaefer EA, Wolski D, Meixong J, Goto K, Brisac C, Chusri P, Fusco DN, Chevaliez S,

Luther J, Kumthip K, Urban TJ, Peng LF, Lauer GM, Chung RT. Kinetic differences in the induction of

interferon stimulated genes by interferon-a and interleukin 28B are altered by infection with hepatitis C

virus. Hepatology. 2014 Apr; 59(4):1250-61.

View in: PubMed

(Peter) Geon Kim, MD

Year Entered: 2015

Fellowship Interests: Hematology / Oncology I was born in South Korea but I grew up mostly in Lexington, MA. I attended

college and medical school at Harvard. My recent research has been in the field of

embryonic hematopoietic transplantation. Specifically, I use genomics and

computation for insight into signaling pathways that promote hematopoietic stem

cell emergence. My past research includes fluid dynamics of antibubble

formation/extinction and sessile evaporating drops.

Selected Publications:

Kim PG, Nakano H, Das PP, Chen MJ, Rowe RG, Chou SS, Ross SJ, Sakamoto KM, Zon LI, Schlaeger TM,

Orkin SH, Nakano A, Daley GQ. Flow-induced protein kinase A-CREB pathway acts via BMP signaling to

promote HSC emergence. J Exp Med. 2015 May 4; 212(5):633-48.

View in: PubMed

Kim PG, Albacker CE, Lu YF, Jang IH, Lim Y, Heffner GC, Arora N, Bowman TV, Lin MI, Lensch MW, De Los

Angeles A, Zon LI, Loewer S, Daley GQ. Signaling axis involving Hedgehog, Notch, and Scl promotes the

embryonic endothelial-to-hematopoietic transition. Proc Natl Acad Sci U S A. 2013 Jan 8; 110(2):E141-

50.

View in: PubMed

Jacob Lazarus, MD, PhD

Year Entered: 2014 Fellowship Interests: Infectious Diseases Email: jlazarus1 North Jersey native and lover of pugs, I am growing to love Boston and its terriers.

I also like biking, running, gin and tonics, fulminant bacterial infections, and cell

biology.

Selected Publications: Ayloo S, Lazarus JE, Dodda A, Tokito M, Ostap EM, Holzbaur EL. Dynactin functions as both a dynamic

tether and brake during dynein-driven motility. Nat Commun. 2014; 5:4807.

View in: PubMed

Lazarus JE, Moughamian AJ, Tokito MK, Holzbaur EL. Dynactin subunit p150(Glued) is a neuron-specific

anti-catastrophe factor. PLoS Biol. 2013 Jul; 11(7):e1001611.

View in: PubMed

Hendricks AG*, Lazarus JE*, Perlson E, Gardner MK, Odde DJ, Goldman YE, Holzbaur EL. Dynein tethers

and stabilizes dynamic microtubule plus ends. Curr Biol. 2012 Apr 10; 22(7):632-7.

View in: PubMed

Jacob Lemieux, MD, DPHil

Year Entered: 2015 Fellowship Interests: Infectious Diseases Email: jelemieux I was born and raised in New York City. I attended college at Stanford, graduate school at Oxford, and medical school at Harvard. My clinical and research interests are in global health, infectious disease, malaria, and babesiosis. In my free time, I enjoy running, cooking, reading, and spending time with my wife, Amy, and our chocolate lab, Huxley.

Selected Publications: Lemieux JE, Kyes SA, Otto TD, Feller AI, Eastman RT, Pinches RA, Berriman M, Su XZ, Newbold CI.

Genome-wide profiling of chromosome interactions in Plasmodium falciparum characterizes nuclear

architecture and reconfigurations associated with antigenic variation. Mol Microbiol. 2013 Nov;

90(3):519-37.

View in: PubMed

Lemieux JE, Gomez-Escobar N, Feller A, Carret C, Amambua-Ngwa A, Pinches R, Day F, Kyes SA, Conway

DJ, Holmes CC, Newbold CI. Statistical estimation of cell-cycle progression and lineage commitment in

Plasmodium falciparum reveals a homogeneous pattern of transcription in ex vivo culture. Proc Natl

Acad Sci U S A. 2009 May 5; 106(18):7559-64.

View in: PubMed

Darrick Li, MD, PhD

Year Entered: 2014 Fellowship Interests: Gastroenterology Email: dkli I'm originally from Acton, MA and have finally come back home via stops at Yale for undergrad and Columbia for med school. At Columbia, my PhD research

focused generally on the role of non-coding RNAs in disease pathogenesis, specifically neurodegeneration. Clinically, I'm interested at this early point in Cardiology, Heme/Onc, GI in no particular order. Outside of the hospital, I love to perform all sorts of music (I was in an 80s cover band in med school), go for long runs, eat awesome food, travel to far off lands, and cheer riotously and unabashedly for Boston sports teams (for better or for worse). Selected Publications: Li DK, Tisdale S, Lotti F, Pellizzoni L. SMN contro of RNP assembly: from post-transcriptional gene

regulation to motor neuro disease. Semin Cell Dev Biol. 2014: 32:22-9.

View in: PubMed

Li DK*, Tisdale S*, Espinoza-Derout J*, Saieva L, Lotti F, Pellizzoni L. A cell system for phenotypic

screening of modifiers of SMN2 gene expression and function. PLoS One. 2013; 8(8):e71965.

View in: PubMed

Scott Millman, MD, PhD

Year Entered: 2014 Fellowship Interests: Hematology / Oncology Email: smillman Originally from Long Island, New York, I completed my undergraduate training at Cornell University. I then moved to New York City, where I completed my MD/PhD at the NYU School of Medicine. My thesis research was focused on the molecular mechanisms underlying the development of hematologic malignancies. When not in the hospital or laboratory, I am an avid sports fan, and enjoy both

baseball and hockey. I also enjoy trying new restaurants, attempting my own creations in the kitchen, and exploring new places with my fiancée. Selected Biography: Busino L*, Millman SE*, Pagano M. SCF-mediated degradation of p100 (NF-?B2): mechanisms and

relevance in multiple myeloma. Sci Signal. 2012 Dec 4; 5(253):pt14.

View in: PubMed

Busino L, Millman SE, Scotto L, Kyratsous CA, Basrur V, O'Connor O, Hoffmann A, Elenitoba-Johnson KS,

Pagano M. Fbxw7a- and GSK3-mediated degradation of p100 is a pro-survival mechanism in multiple

myeloma. Nat Cell Biol. 2012 Apr; 14(4):375-85.

View in: PubMed

Brian Rosborough, MD, PhD

Year Entered: 2015 Fellowship Interests: Pulmonary / Critical Care Email: brrosborough I grew up near Harrisburg, PA and attended Bucknell University as a cell biology/biochemistry major. I went on to complete my MD, PhD at the University of Pittsburgh with a research focus in immunology. In my free time, I enjoy cooking and trying new restaurants. I have been learning French for several years in my spare time. I also enjoy playing golf, exercising, reading, and watching ice

hockey and college football. Selected Publications: Rosborough BR, Mathews LR, Matta BM, Liu Q, Raïch-Regué D, Thomson AW, Turnquist HR. Cutting

edge: Flt3 ligand mediates STAT3-independent expansion but STAT3-dependent activation of myeloid-

derived suppressor cells. J Immunol. 2014 Apr 15; 192(8):3470-3.

View in: PubMed

Rosborough BR*, Raïch-Regué D*, Liu Q, Venkataramanan R, Turnquist HR, Thomson AW. Adenosine

triphosphate-competitive mTOR inhibitors: a new class of immunosuppressive agents that inhibit

allograft rejection. Am J Transplant (Brief Communication). 2014; 14(9):2173-2180.

View in: PubMed

Rosborough BR, Raïch-Regué D, Matta BM, Lee K, Gan B, DePinho RA, Hackstein H, Boothby M,

Turnquist HR, Thomson AW. Murine dendritic cell rapamycin-resistant and rictor-independent mTOR

controls IL-10, B7-H1, and regulatory T-cell induction. Blood. 2013 May 2; 121(18):3619-30.

View in: PubMed

Johannes Scheid, MD, PhD

Year Entered: 2015 Fellowship Interests: Gastroenterology Email: fscheid Born in New York I left the US at the age of 7, grew up in Germany and went to

medical school in Berlin. I came back to New York during medical school for my

PhD at Rockefeller and for my last year rotations at Cornell. I am excited to have

the chance to translate some of my research in the field of HIV immunology into

clinical application at the moment. I hope to find many new friends in Boston and

maybe have some time to pursue my two hobbies, playing the cello and cooking with friends.

Selected Publications: Scheid JF, Mouquet H, Ueberheide B, Diskin R, Klein F, Oliveira TY, Pietzsch J, Fenyo D, Abadir A, Velinzon K, Hurley A, Myung S, Boulad F, Poignard P, Burton DR, Pereyra F, Ho DD, Walker BD, Seaman MS, Bjorkman PJ, Chait BT, Nussenzweig MC. Sequence and structural convergence of broad and potent HIV antibodies that mimic CD4 binding. Science. 2011; 333(6049):1633-7. View in: PubMed Scheid JF, Mouquet H, Feldhahn N, Seaman MS, Velinzon K, Pietzsch J, Ott RG, Anthony RM, Zebroski H, Hurley A, Phogat A, Chakrabarti B, Li Y, Connors M, Pereyra F, Walker BD, Wardemann H, Ho D, Wyatt RT, Mascola JR, Ravetch JV, Nussenzweig MC. Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals. Nature. 2009; 458(7238):636-40. View in: PubMed Scheid JF, Mouquet H, Kofer J, Yurasov S, Nussenzweig MC, Wardemann H. Differential regulation of self-reactivity discriminates between IgG+ human circulating memory B cells and bone marrow plasma cells. Proc Natl Acad Sci USA. 2011; 108(44):18044-8. View in: PubMed

Zirui Song, MD, PhD

Year Entered: 2014 Fellowship Interests: Academic Medicine Email: zsong I was raised by two wonderful parents, my mom an English teacher and my dad an oral surgeon. Growing up in Wisconsin, I became a fan of the Green Bay Packers. My foam cheese head traveled with me to upstate New York, where I finished high school, then to Baltimore for college at Johns Hopkins. Studying public health and economics there inspired me deeply, leading me to become fascinated by the issues facing our health care system and, in turn, our society. I

was fortunate to pursue these interests as a medical student and graduate student in the Health Policy PhD program at Harvard, where my dissertation focused on the economics of payment reform for physician organizations, Medicare fee changes, and the Medicare financing system. Fond memories of the past 8 years include working with the Massachusetts Medical Society, the Albert Schweitzer Fellowship in Boston, and the Center for Primary Care at Harvard Medical School. In my spare time, I enjoy playing basketball and ultimate Frisbee, as well as spending time with my better half, Katie Koh, who is starting in the MGH-McLean Psychiatry residency. We are grateful for the opportunity to train together and excited for the journey ahead. Selected Publications: Song Z, Rose S, Safran DG, Landon BE, Day MP, Chernew ME. Changes in health care spending and

quality 4 years into global payment. N Engl J Med. 2014 Oct 30; 371(18):1704-14.

View in: PubMed

Song Z, Landon BE. Controlling health care spending--the Massachusetts experiment. N Engl J Med.

2012 Apr 26; 366(17):1560-1.

View in: PubMed

Song Z, Safran DG, Landon BE, He Y, Ellis RP, Mechanic RE, Day MP, Chernew ME. Health care spending

and quality in year 1 of the alternative quality contract. N Engl J Med. 2011 Sep 8; 365(10):909-18.

View in: PubMed

Sean Spencer, MD, PhD

Year Entered: 2015 Fellowship Interests: Gastroenterology Email: spspencer I was born and raised in Madison, Wisconsin and attended college at University of Wisconsin where I studied microbiology & immunology and was on the triathlon team. For medical school, I traveled to Philadelphia to study at University of Pennsylvania. I temporarily relocated to Washington D.C. for my PhD research looking at dietary influences on the immune system. In my free time, I enjoy all things outdoors and am looking forward to exploring New England. When not in

the hospital you’ll likely find me running or biking around Boston. Selected Publications: Spencer SP*, Wilhelm C*, Yang Q, Hall JA, Bouladoux N, Boyd A, Nutman TB, Urban JF Jr, Wang J, Ramalingam TR, Bhandoola A, Wynn TA, Belkaid Y. Adaptation of innate lymphoid cells to a micronutrient deficiency promotes type 2 barrier immunity. Science. 2014; 343(6169):432-7. View in: PubMed

Spencer SP, Belkaid Y. Dietary and commensal derived nutrients: shaping mucosal and systemic

immunity. Curr Opin Immunol. 2012 Aug; 24(4):379-84.

View in: PubMed

Klebanoff CA, Spencer S P, Torabi-Parizi P, Grainger J R, Roychoudhuri R, Ji Y, Sukumar M, Muranski P, Scott C D, Hall J A, Ferreyra G A, Leonardi A J, Borman ZA, Wang J, Palmer DC, Wilhelm C, Cai R, Sun J, Napoli JL, Danner RL, Gattinoni L, Belkaid Y, Restifo NP. Retinoic acid controls the homeostasis of pre-cDC-derived splenic and intestinal dendritic cells. J Exp Med. 2013; 210(10):1961-76. View in: PubMed

Molly Thomas, MD, PhD

Year Entered: 2014 Fellowship Interests: Gastroenterology Email: mfthomas I was born and raised in San Francisco and ventured all of 35 miles to Stanford for college. Between college and medical school I did research at the NIH, and then returned to the west coast to start an MD PhD program at UCSF. For my doctoral work I studied microRNA regulation of lymphocyte differentiation and effectors function. When I finally grow up I hope to be a gastroenterologist. I love eating

and cooking, and when I’m not thinking about food I enjoy riding my road bike, hiking up mountains, and throwing Frisbees. I’m excited to be moving eastward to a land of seasons with my wife, who is finishing her PhD in epidemiology. Selected Publications: Thomas MF, L’Etoile ND, Ansel KM. Eri1: a conserved enzyme at the crossroads of multiple RNA-

processing pathways. Trends Genet. 2014; 30(7):298-307.

View in: PubMed

Thomas MF, Abdul-Wajid S, Panduro M, Babiarz JE, Rajaram M, Woodruff P, Lanier LL, Heissmeyer V,

Ansel KM. Eri1 regulates microRNA homeostasis and mouse lymphocyte development and antiviral

function. Blood. 2012; 120(1):130-42

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Steiner DF, Thomas MF, Hu JK, Yang Z, Babiarz JE, Allen CD, Matloubian M, Blelloch R, Ansel KM.

MicroRNA-29 regulates T-box transcription factors and interferon-gamma production in helper T cells.

Immunity. 2011; 35(2):169-81.

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Diane Tseng, MD, PhD Year Entered: 2013 Fellowship Interests: Hematology / Oncology Email: dtseng My name is Diane Tseng and I was born in California to parents who are engineers

and now farmers. I went to Stanford for undergrad and majored in Biology, and

then went on the MD/PhD program in Irv Weissman’s lab studying the

mechanism of action of anti-CD47 antibody. I plan to pursue heme/onc in the

future and my interest lies in cancer immunotherapy. Outside the hospital, I enjoy

playing tennis, figure skating, and sailing.

Selected Publications:

Tseng D, Volkmer JP, Willingham SB, Contreras-Trujillo H, Fathman JW, Fernhoff NB, Seita J, Inlay MA,

Weiskopf K, Miyanishi M, Weissman IL. Anti-CD47 antibody-mediated phagocytosis of cancer by

macrophages primes an effective antitumor T-cell response. Proc Natl Acad Sci U S A. 2013 Jul 2;

110(27):11103-8.

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Tseng D, Vasquez-Medrano DA, Brown JM. Targeting SDF-1/CXCR4 to inhibit tumour vasculature for

treatment of glioblastomas. Br J Cancer. 2011 Jun 7; 104(12):1805-9.

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Patrick Ward, MD, PhD

Year Entered: 2014 Fellowship Interests: Endocrinology Email: psward After undergrad at Dartmouth and a year in Cambridge, UK, I started and ended

my MD/PhD at Penn, with a hiatus of 2 years spent at Memorial Sloan-Kettering.

My Ph.D. work was in the field of cancer metabolism, where I focused on

characterizing mutations in the isocitrate dehydrogenase (IDH) metabolic enzymes, now known to be

prevalent in multiple cancers. I determined that IDH mutations do not act via dominant negative

inhibition, contrary to what had been initially reported in Science. Instead, the common feature of IDH1

and IDH2 mutations is the acquisition of a neomorphic enzymatic activity that results in production of an

onco-metabolite, 2-hydoxyglutarate (2HG). 2HG was previously believed to play a minimal role in

cellular metabolism, but in IDH mutant cancers this metabolite accumulates to 5-20 mM and acts as an

oncogenic effector by inhibiting enzymes involved in histone and DNA demethylation. I plan to continue

following my passion for studying metabolism through a fellowship in endocrinology.

Selected Publications: Dang L, White DW, Gross S, Bennett BD, Bittinger MA, Driggers EM, Fantin VR, Jang HG, Jin S, Keenan

MC, Marks KM, Prins RM, Ward PS, Yen KE, Liau LM, Rabinowitz JD, Cantley LC, Thompson CB, Vander

Heiden MG, Su SM. Cancer-associated IDH1 mutations produce 2-hydroxyglutarate. Nature. 2009 Dec

10; 462(7274):739-44.

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Ward PS, Patel J, Wise DR, Abdel-Wahab O, Bennett BD, Coller HA, Cross JR, Fantin VR, Hedvat CV, Perl

AE, Rabinowitz JD, Carroll M, Su SM, Sharp KA, Levine RL, Thompson CB. The common feature of

leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-

ketoglutarate to 2-hydroxyglutarate. Cancer Cell. 2010 Mar 16; 17(3):225-34.

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Ward PS, Thompson CB. Metabolic reprogramming: a cancer hallmark even warburg did not anticipate.

Cancer Cell. 2012 Mar 20; 21(3):297-308.

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Lauren Zeitels, MD, PhD

Year Entered: 2015 Fellowship Interests: Hematology / Oncology Email: lzeitels I grew up in New Jersey before moving to Philadelphia to attend the University of Pennsylvania. Upon graduation I pursued an MPhil in Medical Genetics as a Gates Scholar at the University of Cambridge. I returned to the US to complete my MD/PhD at Johns Hopkins School of Medicine (by way of UTSW). My research focused on the role of miR-26 in colorectal cancer. In my free time I try to travel:

explore new places, try new foods, and experience new cultures. On a sunny day you might find me on the tennis courts or attempting a run along the water. Selected Publications: Zeitels LR, Acharya A, Shi G, Chivukula D, Chivukula RR, Anandam JL, Abdelnaby AA, Balch GC, Mansour

JC, Yopp AC, Richardson JA, Mendell JT. Tumor suppression by miR-26 overrides potential oncogenic

activity in intestinal tumorigenesis. Genes Dev. 2014 Dec 1; 28(23):2585-90.

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Tao Zou, MD, PhD

Year Entered: 2013

Fellowship Interests: Hematology / Oncology Email: tzou I was born in Shanghai, China and immigrated to the US as a child. I grew up

mostly in Newton, MA, but have lived in East Lansing, MI, Atlanta, GA for college,

and Philadelphia, PA for medical school. I enjoy food, sports, traveling, and

science.

Selected Publications:

Zou T, Caton AJ, Koretzky GA, Kambayashi T. Dendritic cells induce regulatory T cell proliferation through

antigen-dependent and -independent interactions. J Immunol. 2010; 185(5):2790-9.

View in: PubMed

Zou T, May RM, Koretzky GA. Understanding signal integration through targeted mutations of an

adapter protein. FEBS Lett. 2010; 584(24):2901-9.

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