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  • CLEAN-IN-PLACE:

    BHS MEETING THE REQUIREMENTS

    IN THE CHEMICAL, PHARMACEUTICAL

    AND FOOD INDUSTRIES

    Tim Ochel, Project Manager

    Filtration Application Engineering

    BHS-Sonthofen GmbH

    Website: www.bhs-filtration.com

    http://www.bhs-filtration.com/ http://www.bhs-filtration.com/ http://www.bhs-filtration.com/

  • BHS Rotary Pressure Filter:

    Chemical, Pharmaceutical and Food

    Applications

  • © BHS-Sonthofen

    BHS-Sonthofen GmbH Location

  • © BHS-Sonthofen

    BHS-Sonthofen GmbH

    Divisions

    Filtration

    Technology

    Mixing

    Technology

    Crushing

    Technology

    Recycling

    Technology

  • © BHS-Sonthofen

    BHS-Filtration New Location

    • New Location for

    three divisions

    • 14,000 ft2 Facility

    Office, Laboratory

    and Warehouse

    • $1.3 million

    Investment

    BHS-Sonthofen Inc., Charlotte, NC

    Filtration, Mixing & Recycling

  • © BHS-Sonthofen

    • Pressure & Vacuum Filtration

    • Batch & Continuous Operation

    • High Solids to Clarification

    • Cake Washing & Drying

    • Automatic Discharge

    • Wet Cake

    • Dry Cake

    • Concentrated Slurry

    BHS Technology Portfolio

  • © BHS-Sonthofen

    Candle Filter

    Pressure Plate Filter

    Autopress

    Rotary Pressure Filter Indexing Belt Filter

    Rubber Belt Filter

    BHS Filtration Technology Portfolio

  • © BHS-Sonthofen

    SELECTION OF FILTRATION

    TECHNOLOGY

    CAKE STRUCTURE /PROCESS

    PARAMETERS FROM LAB TESTING

    • Filtration Pressure

    • Cake Thickness

    • Filter Media

    • Cake Washing

    • Cake Drying

    • Cake Discharge

    • Cycle Times

    • Process Guarantees

  • © BHS-Sonthofen

    BHS-Filtration New Location BHS Laboratories:

    Charlotte, NC / Sonthofen, Germany

  • © BHS-Sonthofen

    BHS Lab Testing

  • © BHS-Sonthofen

    BHS Lab Testing:

    Pressure or Vacuum

  • © BHS-Sonthofen

    BHS Lab Testing:

    Pressing – Drying for Vacuum

    Air for

    Pressing

    For

    Vacuum

    Filtration

    Air for Blowing

    for Cake Drying

  • © BHS-Sonthofen

    BHS Lab Testing: Cake Structure

  • © BHS-Sonthofen

    BHS Rotary Pressure Filter (RPF)

    BHS Rotary Pressure Filter (RPF) Page 14

  • © BHS-Sonthofen

    Main components

    BHS Rotary Pressure Filter (RPF) Page 15

    housing bearing shield control head drive drum

    cake discharge separating elements filter cells

  • © BHS-Sonthofen

    Functional principle

    BHS Rotary Pressure Filter (RPF) Page 16

    BHS rotary pressure filter with center drive

     “Three in one” machine: filtration, washing, drying

     Hydraulic (gas free) filtration and washing

     Multi step counter-current cake washing

     Completely enclosed process room

     Internal pressure release: cake discharge at ambient pressure

  • © BHS-Sonthofen

    Machine design

    BHS Rotary Pressure Filter (RPF) Page 18

    For toxic or hazardous media:

     Second containment

     Closed bearing shields

     Leakage detection

  • © BHS-Sonthofen

    Applications

    BHS Rotary Pressure Filter (RPF) Page 19

    Agrochemicals

    Pharmaceuticals

    Organic chemicals

    Intermediate plastic products

    Natural extracts

    Cellulose products

    Dyes and pigments Food

  • © BHS-Sonthofen

    Clean-In-Place Requirements

    BHS Rotary Pressure Filter (RPF) Page 20

    Avoiding of potential contamination by solid deposit:

     Cross contamination

     micro-bacterial contamination

    Requirement:

     cGMP design and engineering of the installation

     Effective, efficient and reliable cleaning procedure.

  • © BHS-Sonthofen

    Cleaning-in-place (CIP)

    BHS Rotary Pressure Filter (RPF) Page 21

    Fully or semi automated cleaning procedure without dismantling the system.

    The five influencing factors:

     Velocity

     Temperature

     Chemicals

     Time

     Technology

  • © BHS-Sonthofen

    CIP mechanism

    BHS Rotary Pressure Filter (RPF) Page 22

     Mechanical:

    Removal of solids by impact with high pressure and

    turbulent flow.

     Chemical:

    Removal of solids by chemical reaction with e.g. caustic

    soda and/or phosphoric and nitric acids

     Sterilization:

    Disinfection with e.g. sodium hypochlorite

  • © BHS-Sonthofen

    Cleaning of the housing

    BHS Rotary Pressure Filter (RPF) Page 23

  • © BHS-Sonthofen

    Hollow cone spray nozzles

    BHS Rotary Pressure Filter (RPF) Page 24

  • © BHS-Sonthofen

    CIP devices

    BHS Rotary Pressure Filter (RPF) Page 25

     Housing and inlets

     Drum and filter media

     Cake discharge chute

  • © BHS-Sonthofen

    Design features

    BHS Rotary Pressure Filter (RPF) Page 26

     Materials and surface roughness

     Good drainage philosophy (“self drain”)

     less gaps and dead ends

  • © BHS-Sonthofen

    Riboflavin test

    BHS Rotary Pressure Filter (RPF) Page 27

  • © BHS-Sonthofen

    Example: CIP in Food Application

    BHS Rotary Pressure Filter (RPF) Page 28

    Process step Time [min] Washing agent Recycling

    Filter draining 3 - -

    Pre-rinse 3 water no

    Main cleaning 1 40 detergent yes

    Main cleaning 2 80 detergent yes

    Subsequent cleaning 20 water yes

    Final rinse 3 water no

  • © BHS-Sonthofen

    Example: CIP in Food Application

    BHS Rotary Pressure Filter (RPF) Page 29

     Total rinsing consumption: approx. 4 m³

     Max. temperature rinsing liquid: 60°C

     Cleaning time: approx. 3 h

     Cleaning period: weekly

     Velocity filtrate pipes: approx. 2 m/s

  • © BHS-Sonthofen

    Pharma Applications

     40 rotary pressure filters for active pharmaceutical products (API) within the last 15 years

     FDA approved sealing material

     ATEX rated machine design

     Safe and tight process

     High efficient multiple step cake washing and extraction

    BHS Rotary Pressure Filter (RPF) Page 30

  • © BHS-Sonthofen

    Success story – Pharma

    Application  Product: antibiotics

     Suspension: app. 2 m³/h,

    solids in isopropanol

     Filter area: 2,16 m²

     Cake thickness: 12 mm

     Production rate:

    app. 130 kg/h incl. moisture

     Process steps: filtration,

    cake washing with water and

    isopropanol, dewatering with

    nitrogen

    BHS Rotary Pressure Filter (RPF) Page 32

  • © BHS-Sonthofen

    Highlights review

    BHS Rotary Pressure Filter (RPF) Page 34

    Hydraulic (gas free) filtration

    Counter current cake washing

    Cake discharge at ambient pressure,

    no lock system

    Fully automatic cleaning-in-place system

  • © BHS-Sonthofen

    Tim Ochel, Project Manager

    Filtration Application Engineering

    BHS-Sonthofen GmbH

    Website: www.bhs-filtration.com

    Thank You!

    http://www.bhs-filtration.com/ http://www.bhs-filtration.com/ http://www.bhs-filtration.com/