Clean-In-Place (CIP) Applications in the Pharmaceutical and Food and Beverage Industries

Background

The Measurement

Results

Process

Process piping and vessels used in the pharmaceutical and food and beverage industries require periodic cleaning without disassembly to remove residue from previous batches and to sanitize both the process piping and vessels. Depending upon the industry and the particular products involved, the cleaning can involve alternately flushing with water, caustic solutions, acid solutions, sanitizing (bleach) solutions, and steaming to kill microorganisms.

One of the major requirements for equipment and sensors used in CIP applications is that they be sanitary in design. This means that the surface of a sensor should not contain contours or crevices that could trap residue from the product, that could then decay or harbor microorganisms.

The 245 Sanitary Flow-Through Toroidal Conductivity Sensor mounts directly into the cleaning lines via tri-clamp flanges. Toroidal sensor technology seldom requires cleaning and features smooth surfaces, unlike contacting conductivity sensors. Therefore, toroidal sensors are the ideal choice for CIP installations.

Since the various cleaning solutions used are more conductive than the water used for flushing and final rinsing, conductivity can be used to monitor the various cleaning steps and the final rinse. Each cleaning solution’s flush is typically followed by a water flush, so each step of the cleaning process will appear on a strip chart as a series of conductivity increases. The progress of the final rinse can be followed as a decrease in conductivity until the conductivity drops to the conductivity of the rinse water, which indicates that rinsing is complete.

The cleaning solutions used for CIP are used for several cleanings and gradually lose strength due to dilution with residual rinse water and through the cleaning action itself. Conductivity can often be used to monitor the strength of the cleaning solutions to indicate the need for replenishment (Figure 1).

In the high flow, low pressure system, a cascading action serves to clean the lower portions of the process vessels. A typical CIP program entails the following:

Application Note Food & Beverage

� Eliminate Cross-Batch Contamination � Maintain Hygienic Standards � Asset Protection � Water Use Optimization

1. A pre-rinse with RO-treated water, consisting of three bursts, each of a one-minute duration to remove the bulk of the soil load

2. A continuous 30-minute wash of from 0.5 % to1.0 % alkaline detergent at 180 °F (82 °C)

3. A one-minute rinse with RO-treated water4. A 30-second rinse (sometimes ten minutes or more is

requisite) of from 0.5 % to 1.0 % nitric or phosphoric acid solution at 150 °F –180 °F (65 °C – 82 °C)

5. A two-minute rinse with RO-treated water to remove the phosphoric acid residues

6. A final one-minute rinse with deionized water

Instrumentation

1056 Conductivity Analyzer

Figure 1 Clean-In-Place Applications

1066 Conductivity Analyzer

245 Clean-in-Place Toroidal Conductivity Sensor

� Single or dual input � NEMA 4X (IP65) weatherproof,

corrosion-resistant enclosure � Two Isolated current outputs � Easy to use menu structure � USP alarm available

� Large easy-to-read processmeasurements, user-definable display of measurement diagnostic parameters

� Digital Communications – HART® version 7 and FOUNDATION® fieldbus communication protocols available for host monitoring and configuration

� Intuitive menu screens with advanced diagnostics and help screens

� Two 4–20 mA current outputs are standard on the 1066 HART

� Toroidal (inductive) principle measurement of construction

� Meets 3-A sanitary standards � GRAS List wetted materials (PEEK, EP, and 316L

stainless steel)

LIQ-ANO-FoodBev-Pharma-CIP-Applications

Conductivity Sensor / Analyzer LoopBatch

Reactor: Fermentor or Cooking Vessel

Water via Reverse Osmosis or Purified

Water

Phosphoric Acid Wash

(0.5 % to 1.0 % )

Alkaline Detergent (0.5 % to 1.0 %)

Emerson Process ManagementRosemount Analytical Inc.2400 Barranca Parkway Irvine, CA 92606 USAT (949) 757 8500F (949) 474 7250liquid.csc@emerson.com

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