cheminform abstract: n-carbamoylamino alcohols as the precursors of oxazolidinones via...

2000 oxazole derivatives oxazole derivatives R 0220 20 - 106 N-Carbamoylamino Alcohols as the Precursors of Oxazolidinones via Nitrosation-Deamination Reaction. — Treatment of N-carbamoylamino alcohols (I) with NO + [cf. conditions A)] eﬀectively yields oxazolidines of type (II). Addition of an organic cosolvent sometimes improves slightly the yield. Dynamic kinetic resolution of the DL-phenylalanine derivative (V) allows an access to the chiral N-carbamoylamino alcohol (VII) as precursor of (R)-4- benzyloxazolidinone (IIa). The latter is converted to Wittig phosphorane (XII), a suitable synthon in natural product preparation. — (SUZUKI, MASAMI; YAMAZAKI, TAKAHIRO; OHTA, HIROMICHI; SHIMA, KYOKO; OHI, KATSUHIDE; NISHIYAMA, SHIGERU; SUGAI, TAKESHI; Synlett (2000) 2, 189-192; Dep. Chem., Fac. Sci. Technol., Keio Univ., Kohoku, Yokohama 223, Japan; EN) 1

Upload: masami-suzuki

Post on 06-Jun-2016

213 views

Category:

Documents

1 download

Report

Download

Embed Size (px):

TRANSCRIPT

Page 1: ChemInform Abstract: N-Carbamoylamino Alcohols as the Precursors of Oxazolidinones via Nitrosation-Deamination Reaction

2000 oxazole derivatives

oxazole derivativesR 0220

20 - 106N-Carbamoylamino Alcohols as the Precursors of Oxazolidinones viaNitrosation-Deamination Reaction. — Treatment of N-carbamoylaminoalcohols (I) with NO+ [cf. conditions A)] effectively yields oxazolidines of type(II). Addition of an organic cosolvent sometimes improves slightly the yield.Dynamic kinetic resolution of the DL-phenylalanine derivative (V) allows anaccess to the chiral N-carbamoylamino alcohol (VII) as precursor of (R)-4-benzyloxazolidinone (IIa). The latter is converted to Wittig phosphorane (XII),a suitable synthon in natural product preparation. — (SUZUKI, MASAMI;YAMAZAKI, TAKAHIRO; OHTA, HIROMICHI; SHIMA, KYOKO; OHI,KATSUHIDE; NISHIYAMA, SHIGERU; SUGAI, TAKESHI; Synlett (2000) 2,189-192; Dep. Chem., Fac. Sci. Technol., Keio Univ., Kohoku, Yokohama 223,Japan; EN)

Journal of Proteomics - New Jersey Medical Schoolnjms.rutgers.edu/...nitrosationsitesinsolubleguanylylcyclase.pdf · Identiﬁcation of novel S-nitrosation sites in soluble guanylyl

Synthesis of Oxazolidinones: Rhodium-Catalyzed C-H ... · Synthesis of Oxazolidinones: Rhodium-Catalyzed C-H Amination of N-Mesyloxycarbamates. Hélène Lebel*, Laura Mamani Laparra,

Inhibition of nitrosamine formation by ascorbic acid...acid catalyzed nitrosation in the stomach to nitrosation mediated by mammalian cells or bacteria. The use of N-nitrosoproline

Glycopeptides, Oxazolidinones, Streptogramins and Aminoglycosides Hail M. Al-Abdely, MD Consultant, Adult Infectious Diseases King Faisal Specialist Hospital

Kinetics and Mechanism of S-Nitrosation and Oxidation of

Dr. Wolf's CHM 201 & 202 22-1 22.15 Nitrosation of Alkylamines

From New Mechanisms to New Standards of Care...Quinolones. Glycopeptides, Nitroimidazoles, Streptogramins. Trimethoprim. Oxazolidinones. Sulfonamides. Polymyxins, Phenicols. Cephalosporins

22.16 Nitrosation of Alkylamines. Nitrite Ion, Nitrous Acid, and Nitrosyl Cation H+ –O NO O NO H H+…

Durham E-Theses Denitrosation and nitrosation: a kinetic ...3.3.2 Reactions at pH6 71 3.4 Nitrosation of 4-Nitroaniline using NANT 83 SECTION TWO CHAPTER FOUR : An Introduction to

Electronic Supplementary Information Selective Nitrosation ... · Electronic Supplementary Information Selective Nitrosation of Modified Dextran Polymers† ... dextran derivatives

Tasks 1 and 3 Report: Critical Literature Review of Nitrosation ...€¦ · Tasks 1 and 3 Report: Critical Literature Review of Nitrosation/Nitration Pathways Dr. William Mitch, Yale

Protein synthesis inhibitors: Chloramphenicol, Tetracyclines, Macrolides, Clindamycin Streptogramins & Oxazolidinones Pawitra Pulbutr, M.Sc. In Pharm (Pharmacology)