cd4 t cells: fates, functions, and faults by jinfang zhu, and william e. paul blood volume...

CD4 T cells: fates, functions, and faults

by Jinfang Zhu, and William E. Paul

BloodVolume 112(5):1557-1569

September 1, 2008

©2008 by American Society of Hematology

Jinfang Zhu.

Jinfang Zhu, and William E. Paul Blood 2008;112:1557-1569


William E. Paul.



Summary of the 4 CD4 T helper cell fates: their functions, their unique products, their characteristic transcription factors, and cytokines critical for their fate determination.



T-cell differentiation involves instructive differentiation as well as selective expansion of differentiated cells.



Th2 differentiation driven by low concentration of peptide stimulation in vitro consists of an IL-4–independent initiation phase and an IL-4–dependent amplification phase.



Cross regulation among the factors that are involved in Th1 and Th2 differentiation.



Positive and negative regulatory elements within Il4/Il13 loci and their binding to transcription factors.



cd4 t cells: fates, functions, and faults by jinfang zhu, and william e. paul blood volume...

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