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14th World Congress on Gestational Trophoblastic Diseases

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Committees

ISSTD Officers (Executive Committee) President Seung Jo Kim Secretary-Treasurer Michael Seckl Secretary/Treasurer Elect, representative for the Journal of Reproductive Medicine Ross Berkowitz

Journal Editor (effective 9/05) Vilmos Fullop Previous President Ernest Kohorn Website manager, Previous Secretary Laurence A. Cole President Elect (effective 9/07) Barry Hancock Officer

for Southeast Asia L C Wong for Southeast Asia Shigeru Sasaki for Europe Leon Massuger for the Middle East Shaoul Anteby for Australasia Stephen Steigrad

for the USA Don Goldstein John Lurain

for South America Rafael Cortes Charry co-opted member Philip Savage Korean Representative Chan Lee Chinese Representative Xiang Yang Indian Representative P.K Sakharan

Local Organizing Committee Honorary Advisory Board Akira Amemiya

Hiroshi Kato Matsuto Mochizuki Yuji Murata Yukihiro Nagata Iwao Nishiya Hiroaki Soma Hajime Sugimori Hiroyoshi Takamizawa Ichiro Taki Yutaka Tomoda Naoki Tsukamoto

Congress President Norio Wake Secretary-General Tadao Tanaka The 16th Meeting of Japan

Placenta Association Toshiharu Kamura The 26th Meeting of Japan

Tropboblastic Disease study group


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Committees Deputy Secretaries Toshio Hirakawa

Hiroaki Kobayashi Kotaro Fukushima Yousuke Ueoka

Auditors Kozo Ohama Hitoo Nakano Masaomi Takayama

Presidential Advisory Committee Shingo Fujii Takeshi Maruo Yuji Taketani Masamichi Kashimura Setsuko Goto

Scientific Committee Seung Jo Kim Shigeru Saito Hideo Matsui Norimasa Sagawa Tsutomu Dochi Satoshi Hayakawa Bunpei Ishizuka Tsuyoshi Iwasaka Naohiro Kanayama Hidetaka Katabuchi Kiyoko Kato Tatsuhiko Kawarabayashi Fumitaka Kikkawa Yoshiki Kudo Takashi Minegishi Toru Sugiyama Kiyomi Tsukimori Kimio Ushijima Kenzo Sonoda

Chairperson Chairperson Vice Chairperson Vice Chairperson Members

Budget Committee Noriyuki Inaba Chairperson Registration Committee Kazuhiko Hoshi Chairperson Congress Site Committee Hideharu Kanzaki Chairperson Exhibition Committee Ikuo Konishi Chairperson Publicity & promotion Committee Keiichi Isaka Chairperson Hospitality Committee Shigeru Sasaki Chairperson Publication Committee Naohiro Kanayama Chairperson


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Welcome Message

It is a great pleasure to welcome you all to the 14th World Congress on Gestational Trophoblastic Diseases, which will be held in Fukuoka, Japan from November 11 to 14, 2007. This Meeting will be held in conjunction with the 15th Meeting of Japan Placenta Association and the 25th Meeting of Japan Trophoblast Disease study group.

The Venue is JAL Resort Sea Hawk Hotel, located in the sea-side of Fukuoka city that will enable us to offer attractive and comfortable accommodation with convenient access to the scientific sessions, giving us a beautiful view of Hakata Gulf and downtown of Fukuoka city on its both sides.

Japan is very honored to host the 14th World Congress on Gestational Trophoblastic Diseases in Fukuoka city. The scientific program will be lined up with a host of exciting and enlightening presentations by prominent international experts on the latest developments and findings in the field of trophoblast research. The congress will definitely provide an invaluable opportunity for friends of the region as well as those outside the region to share experiences and exchange scientific information. The local organizing committee is making every effort to put together an exciting program under the collaboration with the 15th Meeting of Japan placenta Association and the 25th Meeting of Japan Trophoblastic Disease Study Group.

Fukuoka is the biggest city in Kyushu, which is a western part of Japan. I would like to extend an invitation to you to come and visit us. Apart from the congress, I am sure you will find many attractions and enjoy the experience of bustling and vibrant city life of Fukuoka. We warmly invite all of you, especially young investigators, your families and those coming to visit Japan for the first time, to participate in the 14th World Congress on Gestational Trophoblastic Diseases in Fukuoka, Japan. We very much look forward to welcoming you in Fukuoka in November 2007. Sincerely, Prof. Norio Wake Congress President The 14 World Congress on Gestational Trophoblastic Diseases.


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General Information

Event Title 14th World Congress on Gestational Trophoblastic Diseases

Title of the Simultaneous Event 15th Meeting of Japan Placenta Association 25th Meeting of Japan Trophoblast Disease Study Group.

Host Organizer Organising Committee for the 14th World Congress on Gestational Trophoblastic Diseases

Co-host Japan Placenta Association Japan Trophoblastic Disease Study Group

Supporting Body Fukuoka City Japan Society of Obstetrics and Gynecology Japan Association of Obstetrics and Gynecology

Date November 11-14, 2007

Venue

JAL Resort Sea Hawk Hotel Fukuoka 2-2-3 Jigyohama, Chuo-ku, Fukuoka City 810-8650 JAPAN Tel: +81-92-844-8111 Fax: +81-92-844-7887 http://www.hawkstown.com/hotel/english/index.html

Secretariat

c/o MA Convention Consulting Inc. 5F, Dai 2 Izumi-shoji Bldg., 4-2-6 Kojimachi, Chiyoda-ku, Tokyo 102-0083, JAPAN TEL: +81-3-5275-1191 / FAX: +81-5275-1192

Website http://www.macc.jp/14isstd/

Official Language English and Japanese

Registration & PC Preview

Date Registration Desk PC Preview Desk

Sunday, November 11 15:00-20:00 -

Monday, November 12 8:00-18:00 8:00-17:00

Tuesday, November 13 8:00-18:00 8:00-17:00

Wednesday, November 14 8:00-16:50 8:00-16:50

Receipts must be presented in order to receive Program & Abstracts, Name Card, Certificate of Attendance and Congress Bag. At On-site Registration Desk, payments of registration fee can be made by cash or credit cards. (VISA, JCB, American Express and MasterCard are accepted.)


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General Information

Internet Access / Fax / Copy Internet access, Fax and copy services are available at Guest Relation Desk (4th Fl of the hotel).

Certificate of Attendance Certificate of Attendance will be provided at Registration Desk.

Refreshment Breakfast and coffee will be served in Navis A on the 1st Fl.

Cloak Cloak is on the 1st Fl. of the hotel.

Weather The temperature in Fukuoka in November ranges between 9°C / 48°F and 17°C / 63°F.

Shopping Shops and other sales outlets in Japan are generally open on Saturdays, Sundays and national holidays as well as weekdays from 10:00 to 20:00. Department stores, however, are closed on one weekday, differing by store, and certain specialty shops may not open on Sundays and national holidays.

Currency Exchange Only Japanese yen (¥) is acceptable at regular stores and restaurants. Certain foreign currencies may be accepted at a limited number of hotels, restaurants and souvenir shops. You can buy yen at foreign exchange banks and other authorized money exchangers on presentation of your passport.

Traveler’s Checks and Credit Cards Traveler’s checks are accepted only by leading banks and major hotels in principal cities, and the use of traveler’s checks in Japan is not as popular as in some other countries. VISA, MasterCard, Diners Club, and American Express are widely accepted at hotels, department stores, shops, restaurants and nightclubs.

Tipping In Japan, tips are not necessary anywhere, even at hotels and restaurants.

Electricity Electric current is uniformly 100 volts, AC, throughout Japan, but with two different cycles: 50Hz in eastern Japan including Tokyo, and 60Hz in western Japan including Fukuoka, Kyoto and Osaka. Leading hotels in major cities have two outlets of 100 and 220 volts but their sockets usually accept a two-leg plug only.


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Floor Plan


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General Information


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General Information


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Access to Fukuoka

NARITA INTERNATIONAL AIRPORT (NRT)

6 min.

By Airport Bus JPY 3,000 / 75min. Dep.time: 06:55- 21:20 ( every 10-40 )

15 min. on foot

By Domestic Flights JPY 32,700 / 90min. 45 flights per day

By Domestic Flight JPY 19,500 / 75 min. 6 flights per day

HAKATA STATION

KANSAI INTERNATIONAL

TOJINMACHI STATION

20 min. by taxi approx. JPY2,500

10-15 min. by taxi approx.JYP1,500

NAKASU KAWABATA STATION

20-25min. by taxi approx.JPY2,000-2,500

Chisan Hotel Hakata

Hakata Nakasu Washington Hotel Plaza

5 min. walk

4 min. walk

1 min

2 min.

TENJIN STATION

15 min. by bus / JPY220 6:39-23:45 / Every 10–15 min.

10 min. walk

15 min. walk

5 min.

TOKYO INTERNATIONAL

F U K U O K A A I R P O R T

CENTRAL JAPAN INTERNATIONAL AIRPORT

By Domestic Flights JPY 32,700 / 130 min. 3 flights per day

By Domestic Flights JPY 22,500 / 85 min. 20 flights per day

GION STATION

7 min. walk

1 min

Hakata Excel Hotel Tokyu 1 min. walk

by Subway

AIRPORT ( KIX )

AIRPORT ( HANEDA )( CENTAIR )

( TENJIN BUS TERMINAL )

JAL Resort Sea Hawk Hotel Fukuoka (Venue)


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Map of the Venue


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会場へのアクセス

タクシー（空港－会場）

約20分/約2,500円

6 分

徒歩15分タクシー（各ホテル－会場）

10-15分/約1,500円

徒歩5分

徒歩4分

1 分

2 分

天神駅

(天神バスターミナル)

バス（天神バスターミナル－会場）約15分/220円

徒歩10分

徒歩15分

福岡空港より博多/祇園/中洲川端/天神 250円唐人町 290円唐人町より博多/祇園/中洲川端 250円天神 200円

5 分

祇園駅

徒歩7分

1 分

チサンホテル博多

中洲川端駅徒歩1分

博多中洲ワシントンホテルプラザ

博多エクセルホテル東急

地下鉄1号線（空港線）

タクシー（駅－会場）

約15分/約2,000円バス（駅－会場）博多駅交通センター又は博多駅前約25分/220円

タクシー（空港－各ホテル）約20-25分/約2,000-2,500円

JAL リゾートシーホークホテル福岡 (会場)

博多駅

唐人町駅

福岡空港


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会場の地図


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Social Events

Opening Ceremony & Welcome Party Date: Sunday, November 11, 18:00- Place: Mombasa (5th Fl.)

Banquet Date: Tuesday, November 13, 18:00- Place: Zepp Fukuoka

Closing Ceremony Date: Wednesday, November 14, 16:50- Place: Argos E (1st Fl.)

Zepp Fukuoka Access Map


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Meetings

ISSTD Executive Committee Date: Sunday, November 11, 16:00-18:00, Place: Kashi(1st Fl.)

ISSTD Annual General Meeting Date: Wednesday, November 14, 11:40-12:10 Place: Argos E (1st Fl.)

JTD Business Meeting Date: Monday, November 12, 8:00-9:00 Place: Kashi(1st Fl.)

JPA Council Meeting Date: Tuesday, November 13, 8:00-9:00 Place: Board Room (3rd Fl.)

JPA Business Meeting Date: Wednesday, November 14, 8:00-9:00 Place: Board Room (3rd Fl.)

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Program at a glance


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Tues

day,

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9:00

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Notes for Speakers

Oral presentation Oral presentations will take place in the Room1 (Argos E) or Room2(Navis B) on the 1st floor of JAL Resort Sea Hawk Hotel Fukuoka. All presentations should be given in Microsoft PowerPoint 2000/2002/2003 on a PC. Speakers are asked to submit their presentations on a CD-R (not CD-RW) or an USB memory stick to the technician on the PC Preview Desk at least one hour before their presentation. If you wish to use Macintosh computer, Powepoint 2007(Windows VISTA/Windows XP) or moving images, please bring your own laptop and report to the technician on the PC Preview Desk at least one hour before your presentation. Oral presentation of invited speakers will be 15 minutes followed by 5-minute discussion, and that of other speakers will be 6 minutes followed by 4-minute discussion. Due to the time schedule, speakers must ensure their presentation does not exceed this time limit.

Poster Presentation Posters can be displayed in the Room2 (Navis B) on November 12. Set-up and Removal Hours: Registration and Set-up: Monday, November 12, 8:00-11:00 Removal: Monday, November 12, 18:00-19:00 Poster Tour: Poster presenters are expected to be present at their display during the following hours: Monday, November 12, 16:30-18:00 for Poster Tour. Please Note: * Poster size: 90cm x 120cm (portrait) * A presentation number to be placed at the top left of the poster will be provided by the secretariat. * Each author is requested to indicate "the title," "the authors' names" ,"the authors' affiliations" and "research

content". * Posters should be attached to the boards with thumbtacks provided by the Secretariat. No paste, glue,

staples or nails should be permitted. * Any posters remaining after 19:00 November 12 will be removed and disposed of by the Secretariat.

Scientific Program


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Scientific Program

Sunday, November 11 15:00-20:00 Registration 16:00-18:00 Meeting of the ISSTD Executive Committee 18:00- Opening Ceremony and Welcome Party

Monday, November 12 8:00-18:00 Registration 8:00-9:00 JTD Business Meeting 11:00-18:00 Poster Presentation

SESSION 12-1 : Molecular Genetics and Genome Imprinting 1 Chairperson : Rosemary Fisher (UK) 9:00-9:20 S12-1-1 FAMILIAL RECURRENT HYDATIDIFORM MOLES

Rosemary Fisher1,2), Peter Dixon1), Shaun Decordova1), Neil Sebire2), Philip Savage2), Michael Seckl2)

1) Institute of Reproductive and Developmental Biology, Imperial College London, UK 2) Trophoblastic Screening and Treatment Centre, Charing Cross Hospital, UK

9:20-9:40 S12-1-2 HUMAN EMBRYONIC STEM CELL GENES IN GESTATIONAL TROPHOBLASTIC

DISEASES Annie NY Cheung The University of Hong Kong, China

9:40-10:00 S12-1-3 IMMUNE CELL PROFILING IN NORMAL PREGNANCY, PARTIAL AND COMPLETE

MOLAR PREGNANCY Zoltan Nagymanyoki1), M.J. Callahan1), M.M. Parast2), V. Fulop3), S.C. Mok1), R.S. Berkowitz1)

1) Laboratory of Gynecologic Oncology, Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Brigham and Women’s Hospital, Boston, USA

2) Division of Women’s and Perinatal Pathology, Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA

3) Department of Obstetrics and Gynecology, State Health Center, Budapest, Hungary


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10:00-10:10 S12-1-4 MOLAR PLOIDY IN TWIN PREGNANCIES COMPRISING HYDATIDIFORM MOLE AND CO-EXISTING NORMAL FETUS

Isa Niemann1), L Bolund2), L Sunde1)

1) Dept of clinical genetics, Aarhus University Hospital, Denmark 2) Insitute of Human Genetics, Aarhus University, Denmark

10:10-10:40 Coffee Break

SESSION 12-2 : Molecular Genetics and Genome Imprinting 2 Chairperson: Fumitoshi Ishino (Japan) 10:40-11:00 S12-2-1 P57KIP2 IMMUNOSTAINING AND MOLECULAR CYTOGENETICS: COMBINED

APPROACH FOR CHIMERIC, MOSAIC AND MORPHOLOGICALLY CHALLENGING CASES WITH MOLAR PHENOTYPE

Urvashi Surti, Lori Hoffner Magee Womens Research Institute, University of Pittsburgh, Pittsburgh, PA, USA

11:00-11:20 S12-2-2 PLACENTAL DEFECTS IN MICE LACKING MATERNAL METHYLATION IMPRINTS

Kenichiro Hata Department of Maternal-Fetal Biology, National Research Institute for Child Health and Development, Japan

11:20-11:40 S12-2-3 ESSENTIAL ROLES OF RETROTRANPOSON-DERIVED IMPRINTED GENES,

PEG10 AND PEG11/RTL1, IN MAMMALIAN PLACENTA DEVELOPMENT AND EVOLUTION

Fumitoshi Ishino1), Ryuichi Ono1), Yoichi Sekita1), Sunsuke Suzuki1), Takashi Kohda1), Tomoko Kaneko-Ishino2)

1) Department of Epigenetics, Medical Research Institute, Tokyo Medical and Dental University, Japan 2) Tokai University, School of Health Sciences, Japan

12:00-13:00 Luncheon Seminor supported by Bristol Myers K.K.

Chairperson: Ernest Kohorn (USA) GESTATIONAL TROPHOBLASTIC NEOPLASIA - TREATMENT BEYOND SINGLE AGENTS

Barry Hancock(UK) Trophoblastic Tumour Centre, Weston Park Hospital, Sheffield, UK

SESSION 12-3 : Staging (Evolution of the Staging and Classification in the Management of GTD) Chairperson: Hextan YS Ngan(China)

13:00-13:20 S12-3-1 DYNAMIC STAGING AND RISK FACTOR SCORING SYSTEM FOR GESTATIONAL

TROPHOBLASTIC DISEASE Ernest I. Kohorn Department Gynecology, Yale University School of Medicine, USA


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13:20-13:40 S12-3-2 Evolution of the Staginging and Classification in the Management of GTD Hextan.Y.S.Ngan Department of Obstetrics & Gynaecology, University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong, SAR, China

13:40-14:00 S12-3-3 JAPANESE TRIAL FOR CLASSIFICATION OF GESTATIONAL TROPHOBLASTIC

DISEASES Shigeru Sasaki Ebina General Hospital, Japan

14:00-14:20 S12-3-4 AN EVALUATION OF FIGO 2000 - THE FIRST 5 YEARS

Barry Hancock, Alicia Okines Trophoblastic Tumour Centre, Weston Park Hospital, Sheffield, UK


SESSION 12-4 : Regional Perspectives of Gestational Trophoblastic Disease Chairperson: Vilmos Fülӧp (Hungary)

14:40-15:00 S12-4-1 GESTATIONAL TROPHOBLASTIC DISEASES-THE INDIAN PERSPECTIVE

P K Sekharan1), N S Sreedevi1), Rasheeda Beegam2), B Presannakumari2), Sheela Shenoy3), Umadevi3), U D Bafna 1) Medical College, Calicut, India. 2) Medical College, Trivandrum, India. 3) Kidwai Memorial Institute Of Oncology,Bangalore, India.

15:00-15:20 S12-4-2 THE DIAGNOSTICS AND TREATMENT OF HIGH RISK GTN IN HUNGARY

Vilmos Fulop1), Ivan Szigetvari1), Janos Szepesi2), Miklos Torok1), Ross S. Berkowitz3) 1) Dept OB/GYN, State Health Center, Budapest, Hungary 2) Dept OB/GYN, Gyula Nyiro Hospital, Budapest, Hungary 3) Dept OB/GYN, Brigham and Women’s Hospital, Boston, Massachusetts

15:20-15:40 S12-4-3 REGIONAL PERSPECTIVES OF GESTATIONAL TROPHOBLASTIC DISEASE-

BRAZILIAN REFERRAL CENTERS Izildinha Maesta Trophoblastic Diseases Center of the Department of Gynecology and Obstetrics, Botucatu Medical School, Sao Paulo State University-UNESP, Brazil

15:40-16:00 S12-4-4 REGIONAL PERSPECTIVES OF GESTATIONAL TROPHOBLASTIC DISEASE IN

TURKEY S. Sinan Ozalp Department of Gynecology and Obstetrics, Faculty of Medicine, Eskisehir Osmangazi University, Turkey.


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16:00-16:20 S12-4-5 NATION WIDE REGISTRY FOR MOLAR DISEASE IN THE NETHERLANDS Leon Massuger Radboud University Nijmegen Medical Centre, Department of Obstetrics and Gynaecology, Netherlands

16:20-16:30 S12-4-6 GESTATIONAL TROPHOBLASTIC NEOPLASIA TEATMENT RESULTS AT THE

JOHN I. BREWER TROPHOBLASTIC DISEASE CENTER 1979-2006 COMPARED TO 1962-1978.

Anna V Hoekstra1), JR Lurain1), AW Rademaker2), JC Schink1) 1) Division of Gynecologic Oncology, Northwestern University Feinberg School of Medicine, Chicago, IL USA 2) Department of Preventive Medicine, Feinberg School of Medicine, Chicago, IL USA

16:30-16:50 S12-4-7 EVALUATION OF GESTATIONAL TROPHOBLASTIC NEOPLASIA TREATMENT IN

167 PATIENTS Francois Golfier, C. Labrousse, L. Frappart, B. Mathian, J.P. Guastalla, V. Trillet-Lenoir, T. Hajri, A.M. Schott, D. Raudrant. French Trophoblastic Disease Reference Center, Hôtel-Dieu, 69002 Lyon, France

Poster Tour 16:30-18:00 LIST OF POSTER RESENTATION Please refer to the end of the program


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Tuesday, November 13 8:00-18:00 Registration 8:00-9:00 JPA Council Meeting

SESSION 13-1: Quiscent GTD Chairperson: Ernest Kohorn (USA)

9:00-9:20 S13-1-1 THE MANAGEMENT OF FALSE POSITIVE HCG AND QUIESCENT GESTATIONAL

TROPHOBLASTIC DISEASE Ernest I Kohorn1), Laurence A Cole2) 1) Trophoblast Center, Department Gynecology, Yale University School of Medicine, USA 2) University of New Mexico, Albuquerque, New Mexico.

9:20-9:40 S13-1-2 QUIESCENT GESTATIONAL TROPHOBLASTIC NEOPLASIA

Barry Hancock1), Jan Everard1), Dave Drew1), Melanie Boafo-Yirenkyi2), Michael Seckl1), John Tidy 1) Trophoblastic Tumour Centre, Weston Park Hospital, Sheffield, UK 2) Charing Cross Hospital, London, UK

9:40-10:00 S13-1-3 QUIESCENT GTD AND MINIMALLY INVASIVE GTD

Laurence A Cole USA hCG Reference Service, Obstetrics and Gynecology, University of New Mexico, USA


SESSION 13-2: Trophoblast Differentiation and Fetomaternal Disease Chairperson: Norimasa Sagawa (Japan)

10:20-10:40 S13-2-1 EPIGENETIC CHANGE DURING TROPHOBLAST DIFFERENTIATION

Satoshi Tanaka, J. Tomikawa, N. Hattori, K. Hayakawa, J. Ohgane, S. Yagi, K. Shiota Animal Resource Sci. / Vet. Med. Sci., The Univ. of Tokyo, Japan.

10:40-11:00 S13-2-2 PLACENTAL PATHOLOGY OF IUGR AND TROPHOBLASTIC MIGRATION

Masahiro Nakayama, Yuko Kuwae, Keiko Matsuoka, Masayoshi Arizawa, Noriyuki Suehara Osaka Medical Center and Research Institute for Maternal and Child Health, JAPAN


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11:00-11:20 S13-2-3 LOCAL REGULATION OF UTERINE LYMPHOCYTES IN HUMAN Shigeru Saito, Akitoshi Nakashima, Mika Ito, Tomoko Shima, Arihiro Shiozaki University of Toyama, Japan

11:20-11:40 S13-2-4 TROPHININ-MEDIATED CELL ADHESION AS A MOLECULAR SWITCH FOR ErbB4

ACTIVATION IN HUMAN EMBRYO IMPLANTATION Kazuhiro Sugihara Department of Obstetrics ＆ Gynecology, Hamamatsu University School of Medicine, Japan

11:40-12:00 S13-2-5 ROLE OF ANTIOXIDANT SYSTEM IN THE FETAL GROWTH - OVEREXPRESSION

OF THIOREDOXIN-1 PROMOTES THE FETAL GROWTH IN MICE Takashi Umekawa, Takashi Sugiyama, Tomohisa Kihira, Nao Murabayashi, Lingyun Zhang, Kenji Nagao, Yuki Kamimoto, Norimasa Sagawa Department of Obstetrics and Gynecology, Mie University Graduate School of Medicine, Japan

12:00-12:20 S13-2-6 INVESTIGATION ON GENES INVOLVED IN THE ENDOVASCULAR INVASION OF

HUMAN EXTRAVILLOUS TROPHOBLAST Kotaro Fukushima, Masaharu Murata, Masahiro Hachisuga, Kazuo Asanoma, Kiyomi Tsukimori, Norio Wake Kyushu University, Fukuoka, Japan

12:20-13:20 Luncheon Seminor supported by GE Healthcare

Chairperson: Toshiharu Kamura (Japan)

IMPROVING OUTCOME OF THE TREATMENT IN THE HIGH RISK GTD FROM THE PAST TO THE FUTURE Seung Jo Kim(Korea) Pochon cha university, Korea Gynecologic cancer center

SESSION 13-3: Trophoblastic Neoplasia Chairperson: Michael J Seckl (UK)

13:30-13:50 S13-3-1 RESULTS OF TREATMENT OF PATIENTS WITH GESTATIONAL TROPHOBLASTIC

NEOPLASIA REFERRED TO A TROPHOBLASTIC DISEASE CENTER AFTER FAILURE OF TREATMENT ELSEWHERE

John R. Lurain, Anna V. Hoekstra, Julian C. Schink Brewer Trophoblastic Disease Center, Northwestern University Feinberg School of Medicine, USA

13:50-14:10 S13-3-2 THE PROGNOSIS OF GESTATIONAL TROPHOBLASTIC NEOPLASIA- CLINICAL

EXPERIENCES OF PUMC HOSPITAL FROM 1985 TO 2005 Xiang Yang, YANG Jun-jun, WAN Xi-run, YANG Xiu-yu Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, China


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14:10-14:30 S13-3-3 IDENTIFICATION AND TREATMENT OF HIGH RISK GESTATIONAL TROPHOBLASTIC NEOPLASIA

John Tidy, J Palmer, J Everard, N Hough, R Coleman, B Hancock Sheffield Trophoblastic Disease Centre, Weston Park Hospital, Sheffield, UK

14:30-14:50 S13-3-4 MANAGEMENT OF GESTATIONAL TROPHOBLASTIC NEOPLASIA (GTN) AFTER

EMA/CO: AN UPDATE ON TE/TP, HIGH DOSE AND OTHER NOVEL THERAPIES. Michael J Seckl1), J Wang1), D Short1), I Lindsay1), NJ Sebire1), A Lim1), ES Newlands1), B Hancock2), P Schmid1), PM Savage1) 1) Charing Cross Gestational Trophoblastic Disease Centre, Imperial College Hospitals, UK 2) Sheffield Gestational Trophoblastic Disease Centre, Weston Park Hospital, UK

14:50-15:10 S13-3-5 EARLY CHEMOTHERAPY OF HIGH RISK HYDATIDIFORM MOLE

Chan Lee, YJ Na, SY Lee, SJ Kim, SG Jung, YY Hwang Pochon CHA University Budang CHA Medical Center, College of Medicine Comprehensive Gynecologic Cancer Center South Korea

15:10-15:30 S13-3-6 MANAGEMENT OF LOW RISK GESTATIONAL TROPHOBLAST DISEASE

Philip Savage, D Short, I Lindsay, NJ Sebire, A Lim, H Mitchell, R Harvey, P Schmid, MJ Seckl Dept of Medical Oncology Charing Cross Hospital London UK

15:30-15:50 S13-3-7 A RANDOMIZED PHASE Ⅲ TRIAL COMPARING WEEKLY PARENTERAL

METHOTREXATE AND ”PULSED” DACTINOMYCIN AS PRIMARY MANAGEMENT FOR LOW-RISK GESTATIONAL TROPHOBLASTIC NEOPLASIA (GTN): A GYNECOLOGIC ONCOLOGY GROUP STUDY (G.O.G.)

Raymond Osborne1), V Filiaci2), J Schink3), D Miller4), A Covens1), R Mannel5) 1) University Of Toronto, Canada 2) Gynecologic Oncology Group, Canada 3) Northwestern University, Canada 4) University Of Texas (Southwestern), Canada 5) University Of Oklahoma, Canada

15:50-16:00 S13-3-8 VAGINAL METASTASES IN GESTATIONAL TROPHOBLASTIC NEOPLASIA

Emily Berry, George S. Hagopian, John R. Lurain Brewer Trophoblastic Disease Center, Northwestern University Feinberg School of Medicine, Chicago IL, USA

16:00-16:30 Coffee Break SESSION 13-4: Epidemiology

Chairperson: Raymond Osborne(Canada) 16:30-16:50 S13-4-1 REGISTRATION SYSTEM AND THE INCIDENCE OF GESTATIONAL

TROPHOBLASTIC DISEASE IN JAPAN Kazuhiko Ino, F. Kikkawa Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Japan


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16:50-17:10 S13-4-2 THE CHANGES OF CLINICAL FEATURES OF HYDATIDIFORM MOLE: Wan Xirun, XIANG Yang, HOU Jinlin PUMC Hospital, Beijing, China

17:10-17:30 S13-4-3 RECENT CHANGES OF THE INCIDENCE FOR COMPLETE AND PARTIAL MOLE

IN CHIBA PREFECTURE Hideo Matsui, Maki Kihara, Hirokazu Usui, Emiri Nakata, Makio Shouzu Department of Reproductive Medicine, Chiba University Graduate School of Medicine, Japan


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JPA (Japanese Oral Session)

Tuesday, November 13

JPA SESSION 1 Chairperson: Kotaro Fukushima(Japan)

13:30-13:40 JPA1-1 MICRORNA EXPRESSION PROFILING OF NORMAL HUMAN PLACENTA BY

EXTENSIVE CLONING ANALYSIS Toshihiro Takizawa1), S-S Luo1), T Mishima1), G Ishikawa2), Y Kawahigashi1), T Kanda1), Y Mizuguchi1), T Takizawa1), S Matsubara3), T Takeshita2) 1) Department of Molecular Anatomy and Medicine, Nippon Medical School, Tokyo, Japan 2) Department of Obstetrics and Gynecology, Nippon Medical School, Tokyo, Japan 3) Department of Obstetrics and Gynecology, Jichi Medical University, Tochigi, Japan

13:40-13:50 JPA1-2 EPIGENETIC STABILITY AND DEVELOPMENTAL PLASTICITY IN CLONED

PLACENTAE DURING SOMATIC CELL NUCLEAR TRANSFER Naomi Matsuda1), Sharif Jafar1), Kimiko Inoue2), Narumi Ogonuki2), Hiromi Miki2), Hiroshi Chisaka1), Kunihiro Okamura1), Atsuo Ogura2), Kohzoh Mitsuya3) 1) Department of Obstetrics and Gynecology, Tohoku University School of Medicine, Japan 2) Bioresource Engineering Division, RIKEN Bioresource Center, Japan 3) Biofunctional Science, Tohoku University Biomedical Engineering Research Organization (TUBERO), Japan

13:50-14:00 JPA1-3 INVOLVEMENT OF OLIGOSACCHARIDE CHANGES IN α5β1 INTEGRIN IN

INVASION OF EXTRAVILLOUS TROPHOBLASTS Eiko Yamamoto, Kazuhiko Ino, Kumiko Kidokoro, Noriko Takahashi, Norio Yoshida, Akiko Nakagawa, Seiji Sumigama, Fumitaka Kikkawa Nagoya University Graduate School of Medicine, Japan

14:00-14:10 JPA1-4 THE EFFECTS OF ANTI β 2-GPI ANTIBODY POSITIVE SERA ON PLGF

PRODUCTION FROM CULTURED CHORIOCARCINOMA CELL Souichiro Kuno, Tatsuo Yamamoto, Takayuki Murase, Go Ichikawa, Youji Akoki Department of Obstetrics and Gynecology, Nihon University School of Medicine, Japan

14:10-14:20 JPA1-5 cAMP DEPENDENT INDUCTION OF HUMAN CHORIONIC GONADOTROPIN (hCG)

BY TOLL LIKE RECEPTOR (TLR) 3 AND 9 SIGNALING IN A CHORIOCARCINOMA CELL LINE BEWO

Shihoko Komine-Aizawa1), Hiroko Majima1), Chikako Yoshida-Noro2), Satoshi Hayakawa1) 1) Department of Pathology and Microbiology, Division of Microbiology, Nihon University School of Medicine,

Japan 2) Division of Cell Regeneration and Transplantation, Advanced Medical Research Center, Nihon University

School of Medicine, Japan


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JPA SESSION 2 Chairperson: Shigeru Saito(Japan)

14:20-14:30 JPA2-1 EARLY DETECTION OF POST-MOLAR PERSISTENT HCG FOLLOWING EARLY

STAGE HYDATIDIFORM MOLE Junya Miyoshi, Takashi Ohba, Kikuko Uchino, Hironori Tashiro, Hidetaka Katabuchi Department of Reproductive Medicine and Surgery / Gynecology, Faculty of Medical and Pharmaceutical Science, Kumamoto University, Japan

14:30-14:40 JPA2-2 ABUNDANCE AND LOCALIZATION OF PROSTAGLANDIN F2αRECEPTOR (FP)

mRNA AND PROTEIN AND UTERINE ACTIVATOR PROTEINS IN HUMAN DECIDUA AT PRETERM BIRTH AND TERM BIRTH

Shintaro Makino1), Dean B. Zaragoza2), David M. Olson2), Toshitaka Tanaka1), Satoru Takeda1) 1) Department of Obstetrics and gynecology, Juntendo University School of Medicine, Japan 2) Perinatal Research Centre, University of Alberta, Canada

14:40-14:50 JPA2-3 EVALUATION OF THE EXPRESSION AND ENZYME ACTIVITY OF MATRIX

METALLOPROTEINASE-7 IN FETAL MEMBRANES DURING PREMATURE RUPTURE OF MEMBRANES AT TERM IN HUMANS

Saori Nishihara1), Akimasa Someya2), Hisashi Yonemoto1), Atsuyuki Ota1), Toshitaka Tanaka1), Shigeru Itoh1), Isao Nagaoka2), Satoru Takeda1) 1) Department of Obstetrics and Gynecology, Juntendo University School of Medicine, Japan 2) Department of Host Defense and Biochemical Research, Juntendo University School of Medicine, Japan

14:50-15:00 JPA2-4 A CASE OF PREMATURE LABOR WITH ELEVATION OF PLACENTAL ALKALINE

PHOSPHATASE DURING PREGNANCY Junko Suzuki, Kikuko Uchino, Junya Miyoshi, Takashi Ohba, Hidetaka Katabuchi Department of Reproductive Medicine and Surgery / Gynecology, Faculty of Medical and Pharmaceutical Science, Kumamoto University, Japan

15:00-15:10 JPA2-5 NECROTIC DECIDUITIS BASALIS WITHOUT CHORIOAMNIONITIS

Masayoshi Arizawa, Hiroyuki Kato Department of Pathology, Tokyo metropolitan Ohtsuka Hospital, Japan

15:10-15:20 JPA2-6 A COMPARISON OF PATHOHISTOGENESIS BETWEEN CHORANGIOMA AND

CHORANGIOSIS Gen Ishikawa1), Hiroaki Soma2), Hiroyuki Osawa2), Tatsuo Oguro3), Kayoko Tanaka4), Shoichiro Mineo5) 1) Deparment of Obstetrics ＆ Gynecology, Nippon Medical School, Japan 2) Department of Obstetrics ＆ Gynecology, Saitama Medical School, Japan 3) Nippon Medical School, Chiba Hokuso Hospital, Japan 4) Division of Morphological Science, Saitama Medical School, Japan 5) Department of Pathology, Tokyo Medical University, Japan


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JPA SESSION 3 Chairperson: Kiyomi Tsukimori (Japan)

15:20-15:30 JPA3-1 MEASUREMENT OF PLACENTAL OXYGENATION BY TRANSABDOMINAL

NEAR-INFRARED SPECTROSCOPY IN NORMAL AND GROWTH RESTRICTED FETUS

Kazunao Suzuki1), Kazuhiro Sumimoto2), Kyuya Hirai1), Takakazu Kawamura1), Kayoko Takada1), Satoshi Kimura1), Kinya Takeuchi1), Kazuhiro Sugihara1), Motoi Sugimura1), Naohiro Kanayama1) 1) Department of Obstetrics and Gynecology, Hamamatsu University School of Medicine, Japan 2) Kawasaki City College of Nursing, Japan

15:30-15:40 JPA3-2 AN ATTEMPT TO EVALUATE THE PLACENTAL FUNCTION BY USING

MYOMETRIAL BLOOD FLOW ANALYSIS Tomoo Waseda, Yukio Watanabe, Hideki Tomizawa, Ryouta Fujii, Satoru Makinoda Department of Obstetrics ＆ Gynecology, Kanazawa Medical University, Japan

15:40-15:50 JPA3-3 INVESTIGATION OF MONOCHORIONIC TWINS IN WHICH AT LEAST ONE FETUS

HAS A CONGENITAL HEART DISEASE WITH OR WITHOUT TWIN-TWIN TRANSFUSION SYNDROME

Nobuhiro Hidaka1,2), Kiyomi Tsukimori1), Yoshihide Chiba2), Norio Wake1) 1) Department of Obstetrics and Gynecology, Kyushu University, Japan 2) Department of Perinatology, National Cardiovascular Center, Japan

15:50-16:00 JPA3-4 INTRAPLACENTAL CHORIOCARCINOMA ASSOCIATED WITH A MASSIVE

FETOMATERNAL HEMORRHAGE AT TERM PREGNANCY Kaai Aso1), Yasuo Yumoto1), Satoshi Hojo1), Haruhiko Kondoh2), Nobuhiro Hidaka1), Kotaro Fukushima1), Hiroshi Yagi1), Shinji Ogawa1), Hiroaki Kobayashi1), Kiyomi Tsukimori1), Norio Wake1) 1) Department of Obstetrics and Gynecology, Graduate School of Medical Science,Kyushu University, Fukuoka,

Japan 2) Division of Pathophysiological and Experimental Pathology, Department of Pathology, Graduate School of

Medical Science, Kyushu University, Fukuoka, Japan 16:00-16:10 JPA3-5 A CASE OF INTRAPLACENTAL CHORIOCARCINOMA RESULTING IN

FETOMATERNAL HEMORRHAGE Yayoi Abe, Atsushi Tajima, Takafumi Ujihira, Soushi Kusunoki, Mayuko Maruyama, Fuyuko Nagai, Yuka Yamamoto, Takeshi Taguchi, Noriko Abe, Michio Nojima, Koyo Yoshida Department of Obstetrics and Gynecology, Juntendo Urayasu Hospital, Juntendo University, School of Medicine, Japan


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Wednesday, November 14 8:00-16:50 Registration 8:00-9:00 JPA Business Meeting

SESSION 14-1: Hydatidiform Mole Chairperson: Ross Berkowitz (USA)

9:00-9:20 S14-1-1 DEVELOPMENTS IN THE MANAGEMENT OF MOLAR PREGNANCY

Ross S. Berkowitz1,2), Donald P. Goldstein3) 1) Brigham and Women’s Hospital, United States 2) New England Trophoblastic Disease Center, United States 3) Trophoblastic Tumor Registry, Harvard Medical School, United States

9:20-9:40 S14-1-2 EVALUATION OF THE RISK OF PERSISTENT TROPHOBLASTIC DISEASE AFTER

TWIN PREGNANCY WITH ANDROGENETIC COMPLETE MOLE AND COEXISTING NORMAL FETUS

Hideo Matsui, Maki Kihara, Hirokazu Usui, Emiri Nakada, Makio Shouzu Department of Reproductive Medicine, Chiba University Graduate School of Medicine, Japan

9:40-10:00 S14-1-3 THE HISTOPATHOLOGY OF HYDATIDIFORM MOLE

Michael Wells Acadmic Unit of Pathology, University of Sheffield Medical School, United Kingdom

10:00-10:10 S14-1-4 THE ROLE OF ADJUVANT SURGERY IN THE MANAGEMENT OF GESTATIONAL

TROPHOBLASTIC NEOPLASIA (GTN) Ma. Stephanie Fay Samadan Cagayan, MS Magallanes Dept. of Obstetrics and Gynecology and Dept. of Pharmacology and Toxicology University of the Philippines-Philippine General Hospital-

10:10-10:20 S14-1-5 THE ROLE OF SURGERY IN HIGH-RISK GESTATIONAL TROPHOBLASTIC

DISEASE (GTD) PATIENTS Sharyn N Lewin1), RA Soslow2), MJ Kim3), NR Abu-Rustum1), Y Sonoda1), CL Brown1), S Mironov4), MS Bains5), R Flores5), DS Chi1), CA Aghajanian3) 1) Gynecology Service, Department of Surgery, Memorial-Sloan Kettering Cancer Center, New York, NY, USA 2) Department of Pathology, Memorial-Sloan Kettering Cancer Center, New York, NY, USA 3) Department of Medicine, Memorial-Sloan Kettering Cancer Center, New York, NY, USA 4) Department of Radiology, Memorial-Sloan Kettering Cancer Center, New York, New York, USA 5) Thoracic Service, Department of Surgery, Memorial-Sloan Kettering Cancer Center, New York, NY, USA


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SESSION 14-2: Placental Site Trophoblastic Tumors Chairperson: Laurence Cole (USA)

10:20-10:40 S14-2-1 PLACENTAL SITE TROPHOBLASTIC TUMOR; AN OVERVIEW

Joo-Hyun Nam Department of Obstetrics and Gynecology, College of Medicine, University of Ulsan, Asan Medical Center, Korea

10:40-11:00 S14-2-2 CLINICOPATHOLOGY OF PLACENTAL SITE TROPHOBLASTIC TUMOR

Masaharu Fukunaga Department of Pathology, Jikei University Daisan Hospital, Japan

11:00-11:20 S14-2-3 HCG FREE BETA-SUBUNIT AN OUTSTANDING MARKER OF PSTT

Laurence A. Cole USA hCG Reference Service, Obstetrics and Gynecology, University of New Mexico, USA

11:20-11:40 S14-2-4 AN ANALYSIS OF THE UK EXPERIENCE OF PLACENTAL SITE TROPHOBLASTIC

TUMOURS (PSTT) Michael J Seckl1), Y Nagai2), D Short1), I Lindsay1), NJ Sebire1), A Lim1), R Harvey1), ES Newlands1), B Hancock3), PM Savage1), P Schmid1) 1) Charing Cross Gestational Trophoblastic Disease Centre, Imperial College Hospitals, London, UK 2) Obstetrics and Gynecology Dept, University of the Ryukyus, Okinawa, Japan 3) Sheffield Gestational Trophoblastic Disease Centre, Weston Park Hospital, UK

11:40-12:10 ISSTD Annual General Meeting SESSION 14-3: Imaging

Chairperson: Ting-Chang Chang (Taiwan) 12:40-13:00 S14-3-1 THE ROLE OF 18F-FLUORODEOXYGLUCOSE POSITRON EMISSION

TOMOGRAPHY IN GESTATIONAL TROPHOBLASTIC DISEASE Ting-Chang Chang1,2), Chyong-Huey Lai1,2), Tzu-Chen Yen1,2), Koon-Kwan Ng1,2), Shih-Ming Jung1,2), Yiu-Tai Li1,3) 1) Chang Gung Memorial Hospital Linkou Medical Center, Taoyuan, Taiwan 2) Chang Gung University College of Medicine, Taoyuan, Taiwan 3) Department of Obstetrics and Gynecology, Kuo General Hospital, Tainan, Taiwan

13:00-13:20 S14-3-2 UPDATE IN IMAGING STUDIES IN GESTATIONAL TROPHOBLASTIC DISEASE.

Rafael. Cortes-Charry Trophoblastic Clinic, Department of Obstetrics and Gynecology of Hospital Universitario de Caracas. Universidad Central de Venezuela

13:20-13:40 S14-3-3 IMAGING OF GESTATIONAL TROPHOBLASTIC NEOPLASIA: WHICH MODALITY

IS BEST? Adrian K.P. Lim1,2), Michael Seckl2), Philip Savage2), Linda Dayal2), Katherine Hawtin1), Daksha Patel1), Peter Schmid2) 1) Department of Radiology, Charing Cross Hospital, Fulham Palace Road, London, United Kingdom 2) Trophoblastic Disease Unit, Charing Cross Hospital, Fulham Palace Road, London, United Kingdom


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13:40-14:00 S14-3-4 EFFICACY OF 18F-FLUORODEOXYGLUCOSE POSITRON EMISSION TOMOGRAPHY ON DETECTION OF GESTATIONAL TROPHOBLASTIC NEOPLASIA

Toshiharu Kamura1), Kimio Ushijima1), Keizo Fujiyoshi1), Masatoshi Ishibashi2) 1) Department of Obstetrics and Gynecology, Kurume University Hospital, Japan 2) Department of Radiology, Kurume University Hospital, Japan

14:00-14:10 S14-3-5 HISTEROSCOPIC FINDINGS POST MOLAR EVACUATION WITH MANUAL

ENDOUTERINE ASPIRATION Lina Figueira1), R. Cortes1), Y. Rivas1), A. Morales1), J. Colon2), S. Rebolledo2), A. Lemmo1), C. Santiago1), L. Corredor1) 1) Trophoblastic Clinic of Department of Obstetrics and Gynecology of Hospital Universitario de Caracas,

Venezuela 2) Trophoblastic Clinic, Maternidad Concepcion Palacios, Venezuela

SESSION 14-4: Trophoblast Differentiation and Fetomaternal Disease Chairperson: Mitsutoshi Iwashita(Japan)

14:10-14:30 S14-4-1 MOLECULAR ANALYSIS FOR INTRAUTERINE GROWTH RESTRICTION (IUGR)

Aikou Okamoto1), Hiroko Omi1), Misato Saito1), Rie Kawaguchi1), Takashi Nikaido2), Tadao Tanaka1) 1) Dep. Ob/Gyn Jikei University School Of Medicine, Japan 2) Dep. Pathology Jikei University School Of Medicine, Japan

14:30-14:50 S14-4-2 INVOLVEMENT OF IGF AND IGF-BINDING PROTEIN IN PLACENTAL

DEVELOPMENT AND FUNCTION Mitsutoshi Iwashita Dept. of Ob/Gyn, Kyorin University School of Medicine, Japan

14:50-15:10 S14-4-3 HYPOXIA SUPPRESSES EXPRESSION OF SYNCYTIN AND CELL FUSION

DURING SYNCYTIALISATION OF HUMAN PLACENTAL BeWo CELLS: IMPLICATIONS FOR IMPAIRED TROPHOBALST SYNCYTIALISATION IN PRE-ECLAMPSIA

Yoshiki Kudo Department of Obstetrics and Gynecology, Hiroshima Univeresity, Japan

SESSION 14-5: hCG

Chairperson: CV Rao (USA) 15:10-15:30 S14-5-1 PARALLELS AND DIFFERENCES BETWEEN THE hCG ACTIONS DURING

PREGNANCY AND GESTATIONAL TROPHOBLASTIC DISEASES C.V.Rao University of Louisville Health Sciences Center, United States


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15:30-15:50 S14-5-2 HYPERGLYCOSYLATED hCG (hCG-H) AND THE SOURCE OF PREGNANCY FAILURES

Yasushi Sasaki1), Laurence A. Cole2), Donald G. Ladner2), Sarah A. Khanlian2), Atsushi Yanaihara3), Jun Takahashi1), Takashi Okai4) 1) Department of Obstetrics and Gynecology, Showa University Northern Yokohama Hospital, Japan 2) USA hCG Reference Service, Division of Women’s Health Research, Department of Obstetrics and Gynecology,

University of New Mexico Health Sciences Center 3) Denentoshi Lady’s Clinic, Japan 4) Department of Obstetrics and Gynecology, Showa University School of Medicine, Japan

15:50-16:10 S14-5-3 A FRESH LOOK AT BETA-hCG THROUGH SHEEP MONOCLONAL ANTIBODIES.

Paul Davis1), H Mitchell2), W Stewart3), MJ Seckl2), ES Newlands2), M Davis1), T Stephenson1), F Adair1) 1) Mologic, Colworth Science Park, Bedford, UK, 2) Charing Cross GTD Centre, Imperial College Hospitals, London, UK, 3) Dundee GTD Registration Centre, Ninewells Hospital, Dundee, UK

16:10-16:30 S14-5-4 HUMAN PLACENTAL VILLOUS MACROPHAGES AS A FETAL BIOLOGICAL

SHIELD FROM MATERNAL CHORIONIC GONADOTROPIN Hidetaka Katabuchi Department of Gyecology, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, Japan

16:30-16:50 S14-5-5 BIOLOGY OF HYPERGLYCOSYLATED HCG, THE INVASIVE SIGNAL IN

CHORIOCARCINOMA Laurence A.Cole USA hCG Reference Service, Obstetrics and Gynecology, University of New Mexico, USA

16:50- Closing Ceremony


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List of Poster Presentations P-1. MOLECULAR GENETIC ORIGIN ANALYSIS OF CHORIOCARCINOMA

Zhao Jun, Xiang Yang Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Science, Beijing, China.

P-2. GENETIC MOLECULAR ANALYSIS OF THE ORIGIN OF CHORIOCARCINOMA

Izildhina Maesta1), OC Michelin2), RL Lapate3), LRMG Delmanto1), AR Braga4), KIR Coelho3), CE Paiva2), SR Rogatto5) 1) Department of Gynecology and Obstetrics, Botucatu Medical School, Sao Paulo State University-UNESP, Brazil 2) Department of Internal Medicine, Botucatu Medical School, Sao Paulo State University-UNESP, Brazil 3) Post-Graduation Program of Gynecology, Obstetrics and Mastology, Botucatu Medical School, Sao Paulo State

University-UNESP, Brazil 4) Department of Patology, Botucatu Medical School, Sao Paulo State University-UNESP, Brazil 5) Department of Urology, Botucatu Medical School, Sao Paulo State University-UNESP, Brazil

P-3. UTILITY OF THE P57 PROTEIN (kip2) IN MOLAR DISEASE TO DETERMINE ITS ANDROGENETIC

ORIGIN. Rafael. Cortes-Charry1), V. Garcia-Barriola2), L. Figueira1) 1) Trophoblastic Clinic of Department of Obstetrics and Gynecology of Hospital Universitario de Caracas 2) Anatomopathologic Institute. Jose Antonio O.Daly. Universidad Central de Venezuela

P-4. ANALYSIS OF SIRH-FAMILY: RETROTRANSPOSON-DERIVED GENES HIGHLY CONSERVED IN

MAMMALS M. Naruse1,2), R. Ono1), Y. Sekita1), K. Nakamura3), T. Kohda1), M. Yokoyama4), T. Kaneko-Ishino5), F. Ishino1) 1) Department of Epigenetics, Medical Research Institute, Tokyo Medical and Dental University, Japan 2) Research Fellow of the Japan Society for the Promotion of Science, Japan 3) Mitsubishi Kagaku Institute of Life Science, Japan 4) Brain Research Institute, Niigata University, Japan 5) School of Health Sciences, Tokai University, Japan

P-5. REGULATION OF PLACENTA GROWTH FACTOR (PLGF) IN TROPHOBLAST DERIVED CELLS UNDER

HYPOXIC CONDITIONS Fumihito Nishimoto1), Ryoko Minekawa1), Yoko Okamoto2), Asako Miyake1), Aki Isobe4), Toshiya Yamamoto4), Takashi Takeda3), Masahiro Sakata1), Tadashi Kimura 1) Osaka university, Japan 2) Osaka medical center and research institute for maternal and child health, Japan 3) Osaka medical center for cancer and cardiovascular disease, Japan 4) Sakai municipal hospital, Japan

P-6. EXPRESSION OF PLACENTAL E2-EPF UBIQUITIN CARRIER PROTEIN (UCP) IS DOWN-REGULATED IN

PREECLAMPSIA Takamoto Onodera, Hirotaka Nishi, Chinatsu Higuma, Fumitoshi Terauchi, Keiichi Isaka Department of Obstetrics and Gynecology, Tokyo Medical University, Japan

P-7. CD98hc ACTIVATES αvβ3 INTEGRIN SIGNALS AT THE HUMAN EMBRYO-MATERNAL INTERFACE

N Tamura2), K Sugihara1), M Kabir-Salmani2), S Shiokawa2), K Sakai2), N Kanayama1), M Iwashita2) 1) Departments of Obstetrics and Gynecology, Hamamatus University School of Medicine, Japan 2) Departments of Obstetrics and Gynecology, Kyorin University School of Medicine, Japan


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P-8. THE MOLECULAR GENETIC ANALYSIS OF EPITHELIOID TROPHOBLASTIC TUMOR BY USING SHORT TANDEM REPEAT SEQUENCES Satoshi Urabe1), Osamu Samura2), Hisaya Fujiwara1), Hiroshi Miyoshi1), Hiroaki Soma3), Yoshiki Kudo1) 1) Department of Obstetrics and Gynecology, Hiroshima University, Hiroshima, Japan 2) Department of Obstetrics and Gynecology, National Hospital Organization Kure Medical Center, Hiroshima, Japan 3) Department of Obstetrics and Gynecology, Saitama Medical School, Saitama, Japan

P-9. LOW RISK GESTATIONAL TROPHOBLASTIC NEOPLASIA: DO PATIENTS NEED TO BE IN HOSPITAL

FOR THEIR FIRST CYCLE OF METHOTREXATE? Lucy Carter, Jan Everard, Barry Hancock Trophoblastic Tumour Centre, Weston Park Hospital, Sheffield, UK

P-10. AUTOPHAGY, BULK DEGRADATION SYSTEM, PROMOTES EXTRAVILLOUS TROPHOBLAST INVASION

IN LOW NUTRIENT, HYPOXIA OR HYPOGLYCEMIC CONDITION Akitoshi Nakashima, Mikiko Tatematsu, Shigeru Saito Department of Obstetrics and Gynecology, Faculty of Medicine, University of Toyama , Japan

P-11. ELEVATION OF SERUM METASTIN CONCENTRATIONS IN HUMAN PREGNANCY

Jun Yoshimatsu, Yuichi Furukawa, Junichiro Fukuda, Hisashi Narahara Department of Obstetrics and Gynecology, Faculty of Medicine, Oita University, Japan

P-12. THE EFFECTS OF RELAXIN ON THE INVASIVE POTENTIAL IN CULTURED EARLY HUMAN PLACENTAL

EXTRAVILLOUS TROPHOBLASTS. Nobuyuki Maruo, Koji Nakabayashi, Senn Wakahashi, Ai Yata, Takeshi Maruo Department of Obstetrics and Gynecology, Kobe University Graduate School of Medicine, Japan

P-13. THE INFLUENCE OF AGE AS A FACTOR IN THE OUTCOME OF GESTATIONAL TROPHOBLASTIC

DISEASE. Julia E Palmer1), BW Hancock2), JA Tidy1,2) 1) Dept Gynaecological Oncology, Sheffield Teaching Hospitals NHS trust, Sheffield, UK 2) Sheffield Trophoblastic Disease Centre, Sheffield, UK

P-14. DIAGNOSTIC CHALLENGES IN EXTRAUTERINE EPITHELOID TROPHOBLASTIC TUMOURS; A REPORT

OF TWO CASES. MC Macdonald1,2), JE Palmer1), BW Hancock2), JA Tidy1) 1) Department of Gynaecological Oncology, Sheffield Teaching Hospitals NHS Trust, Sheffield, UK 2) Sheffield Trophoblastic Disease Centre, Sheffield, UK

P-15. HISTONE DEACETYLASE INHIBITORS INDUCE GROWTH INHIBITION, CELL CYCLE ARREST AND

APOPTOSIS IN HUMAN CHORIOCARCINOMA CELLS N. Takai, T. Ueda, M. Nishida, K. Nasu, H. Narahara Department of Obstetrics and Gynecology, Oita University Faculty of Medicine, Oita, Japan

P-16 INVASIVE MOLE SHOWING RESISTANCE TO A SINGLE ETOPOSIDE CHEMOTHERAPY

Satoru Takeuchi, Keiko Ebisawa, Koji Terasawa, Hiromi Kinoshita, Susumu Minami, Nobuyuki Morioka, Junko Komatu, Hiromitu Matumoto, Tomoaki Kusume Kochi Health Sciences Center, Japan


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P-17. PREDICTING THE NEED FOR ADDITIONAL DOSES AND LINES OF CHEMOTHERAPY IN PATIENTS WITH LOW RISK GESTATIONAL TROPHOBLASTIC NEOPLASIA AFTER INITIAL TREATMENT WITH METHOTREXATE CHEMOTHERAPY WB Growdon1), AJ Wolfberg2), DP Goldstein3), CM Feltmate3), ME Chinchilla3), ES Lieberman3), RS Berkowitz3) 1) Department of Obstetrics and Gynecology, Massachusetts General Hospital, Boston, USA 2) Department of Obstetrics and Gynecology, New England Medical Center, Boston, USA 3) Department of Obstetrics and Gynecology, Brigham and Women’s Hospital, Boston, USA

P-18. WHOLE BRAIN IRRADIATION AND HIGH-DOSE MTX EMA/CO FOR CHORIOCARCINOMA WITH BRAIN

METASTASES Yutaka Nagai1), Chiaki Yagi1), Kozue Ishimine1), Tsuguhisa Nashiro1), Morihiko Inamine1), Makoto Hirakawa1), Kazuhiko Ogawa2), Takafumi Toita2), Yoshihiko Yoshii3), Sadayuki Murayama2), Yoichi Aoki1) 1) Department of Obstetrics and Gynecology, University of the Ryukyus, Okinawa, Japan 2) Department of Radiology, University of the Ryukyus, Okinawa, Japan 3) Department ot Neurosurgery, University of the Ryukyus, Okinawa, Japan

P-19. MIOMETRIAL NODULE RESEMBLING GESTATIONAL TROPHOBLASTIC NEOPLASIA. A CASE REPORT

Rafael. Cortes-Charry1), L. Figueira1), V. Garcia-Barriola2), M. Gomez2), A. Balza2), P. Ponce1), M. Dolcet1), M. Fargionni3) 1) Trophoblastic Clinic.Department of Obstetrics and Gynecology of Hospital Universitario de Caracas, Venezuela 2) Anatomopathologic Institute. Jose Antonio O´Daly. Universidad Central de Venezuela, Venezuela 3) General Laboratory of Hospital Universitario de Caracas, Venezuela

P-20. MOLAR ECTOPIC PREGNANCY EVOLVING FOR GESTATIONAL TROPHOBLASTIC NEOPLASIA

Patricia Daniela Paranhos Batista Soares1,2), Olivia Lucia Nunes Costa1), Izildinha Maesta2), Itana de Matos Pinto e Passos1), Cleber Gomes1), Ludmila Andrade Costa1), Erika Goulart Veloso Ferreira2) 1) Hospital Climerio de Oliveira- UFBA /Brazil 2) Pos-graduated,estudent -UNESP/ BRAZIL

P-21. EPITHELIOID TROPHOBLASTIC TUMOUR: A REVIEW OF THE LITERATURE

Julia E Palmer1), Macdonald M1), Wells M2), Hancock BW3), Tidy JA1,3) 1) Dept Gynaecological Oncology, Sheffield Teaching Hospitals NHS trus, Sheffield. UK 2) Dept Pathology, Sheffield Teaching Hospitals NHS trust, Sheffield, UK 3) Sheffield Trophoblastic Disease Centre, Sheffield, UK

P-22. ACTINOMYCIN-D VERSUS METHOTREXATE-FOLINIC ACID AS THE TREATMENT OF STAGE I, LOW

RISK GESTATIONAL TROPHOBLASTIC NEOPLASIA, A RANDOMIZED CONTROLLED TRIAL

P-23. TREATMENT OF GESTATIONAL TROPHOBLASTIC NEOPLASIA IN A BRAZILIAN TERTIARY REFERRAL

CENTER OC Michelin1), I Maesta2), P Traiman2), LRMG Delmanto2), MA Gomes2), RA Silva3), I Dalben4), M Consonni2) 1) Department of Internal Medicine, Botucatu Medical School- Sao Paulo State University-UNESP, Brazil 2) Department of Gynecology and Obstetrics, Botucatu Medical School- Sao Paulo State University-UNESP, Brazil 3) Botucatu Medical School- Sao Paulo State University-UNESP, Brazil 4) Department of Public Health, Botucatu Medical School- Sao Paulo State University-UNESP, Brazil

Ruangsak Lertkhachonsuk, S Tangtrakul, N Israngura, S Wilailak Department of Obstetrics and Gynaecology, Ramathibodi Hospital, Mahidol University, Thailand


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P-24. ROLE OF HYSTERECTOMY IN MANAGING GESTATIONAL TROPHOBLASTIC NEOPLASIA John Tidy, J Palmer, J Everard, N Hough, R Coleman, B Hancock Sheffield Trophoblastic Disease Centre, Weston Park Hospital, Sheffield, UK

P-25. CASE REPORT OF PRIMARY TUBAL CHORIOCARCINOMA COEXISTENT WITH A NORMAL

PREGNANCY Yoshiko Komoto, Haruna Kawaguchi, Kim Yong Hwi, Michiko Kodama, Hirofumi Otsuka, Masahiko Takemura Osaka General Medical Center, Japan

P-26. OVARIAN NON-GESTATIONAL CHORIOCARCINOMA ASSOCIATED WITH GONADOBLASTOMA: CASE

REPORT AND REVIEW OF LITERATURE Satoshi Ohira, Saori Kondo, Tsutomu Miyamoto, Akiko Horiuchi, Kazuko Itoh, Tanri Shiozawa, Ikuo Konishi Department of Obstetrics and Gynecology, Shinshu University School of Medicine, Japan

P-27. PROTEASE PROFILE OF CONDITIONED MEDIUM FROM CHORIOCARCINOMA CELL LINES

H Usui, H Matsui, A Mitsuhashi, M Kihara, B Batzorig, E Nakada, M Shozu Reproductive Medicine, Graduate School of Medicine, Chiba University, Japan

P-28. SHORTENED CONTROL PROGRAM FOR PATIENTS WITH TRIPLOID HYDATIDIFORM MOLE

Isa Niemann1), J Blaakjaer1), L Sunde2) 1) Department of Obstetrics and Gynecology, Aarhus University Hospital, Denmark 2) Department of Clinical Genetics, Aarhsu University Hospital, Denmark

P-29. EXTRAUTERINE EPITHELIOID TROPHOBLASTIC TUMORS (ETT) PRESENTING AS PRIMARY LUNG

CARCINOMAS: MORPHOLOGIC AND IMMUNOHISTOCHEMICAL FEATURES TO RESOLVE A DIAGNOSTIC DILEMMA Sharyn N Lewin1), RA Soslow2), CA Aghajanian3) 1) Gynecology Service, Department of Surgery, Memorial-Sloan Kettering Cancer Center, New York, NY, USA 2) Department of Pathology, Memorial-Sloan Kettering Cancer Center, New York, NY, USA 3) Department of Medicine, Memorial-Sloan Kettering Cancer Center, New York, NY, USA

P-30. SEXUAL DYSFUNCTION AS A COMPLICATION OF TREATMENT OF GESTATIONAL TROPHOBLASTIC

NEOPLASIA (GTN) Ma. Stephanie Fay Samadan Cagayan Dept. of Obstetrics and Gynecology and Dept. of Pharmacology and Toxicology University of the Philippines-Philippine General Hospital

P-31. GESTATIONAL PRIMARY PULMONARY CHORIOCARCINOMA WITH HEPATIC METASTASES:

MULTIDISCIPLINARY THERAPY OC Michelin1), I Maesta2), MSS Campos2), RAMB Almeida1), AJM Cataneo3), FG Romeiro1), SR Rogatto4), KIR Coelho5), A Bakonyi Neto3) 1) Oncological Treatment Center of the Department of Internal Medicine, Botucatu Medical School- Sao Paulo State

University- UNESP, Brazil 2) Trophoblastic Diseases Center of the Department of Gynecology and Obstetrics, Botucatu Medical School- Sao Paulo

State University- UNESP, Brazil 3) Department of Cirurgy and Ortopedy, Botucatu Medical School- Sao Paulo State University- UNESP, Brazil 4) Department of Urology, Botucatu Medical School- Sao Paulo State University- UNESP, Brazil Department of Cirurgy

and Ortopedy, Botucatu Medical School- Sao Paulo State University- UNESP, Brazil 5) Department of Pathology, Botucatu Medical School- Sao Paulo State University- UNESP, Brazil


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P-32. A CASE OF CHORIOCARCIMOMA BEGAN WITH TUMOR EMBOLUS AND SUDDENLY GOT WORSE Mihyon Song2), S.Yoshida, 1), N. Ushioda1), K. Shimoya1), Y. Oue2), M.Oka2) 1) Kawasaki Medical University department of Obstetrics and Gynecology, Japan 2) Kawasaki Medical School department of medicine division of respiratory medicine, Japan

P-33. EPIDEMIOLOGICAL FEATURES OF GTD IN FEMALE POPULATION, IRKUTSK PROVINCE

Gladkova Olga1), Pisareva Lubov2), Dvornichenko V.V.1) 1) Regional Oncology Clinic, Irkutsk, Russia 2) Cancer Research Institute, Tomsk, Russia

P-34. PROTEOMIC ANALYSIS ON PATHOGENESIS AND INVASIVE MECHANISM OF HYDATIDIFORM MOLE

Ma Li, Xiang Yang Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing , China

P-35. DIAGNOSIS, TREATMENT AND REHABILITATION OF HYDATIDIFORM MOLE

Tengiz Charkviani, Ts. Kharaishvili, T.Tsintsadze, L.Metonidze Gynaecological Clinic, National Oncological Center, Georgia

P-36. ENDOMETRIAL SAMPLING IN GESTATIONAL TROPHOBLASTIC DISEASE AFTER SUCTION CURETTAGE

Ruangsak Lertkhachonsuk, Surang Treratanachat Department of Obstetrics and Gynecology, Faculty of Medicine, Chulalongkorn University, Thailand

P-37. COMPLETE MOLE IN A TWIN PREGNANCY. A CASE REPORT

Rafael. Cortes-Charry1), A. Castaneda1), L. Figueira1), M. de Gomez2), V. Garcia-Barriola2), J. Navarro2), M. Parilli1), Z. Vivas3), A. Cohen1) 1) Trophoblastic Clinic, Department of Obstetrics and Gynecology of Hospital Universitario de Caracas 2) Anatomopathologic Institute. Jose Antonio O´Daly. Universidad Central de Venezuela 3) Institute of Oncology and Haematology of Universidad Central de Venezuela

P-38. DIAGNOSIS OF COEXISTING COMPLETE HYDATIDIFORM MOLE IN IN TWIN PREGNANCY BY p57KIP2

IMMUNOSTAINING M. Kihara, H. Matsui, B. Baasanjav, H. Usui, M. Shozu Department of Reproductive Medicine, Chiba University Graduate school of Medicine, Japan

P-39. ELEVATED SERUM SFLT1 LEVEL IN HYDATIDIFORM MOLE

Yutaka Osuga, Kaori Koga, Toshiki Tajima, Yasushi Hirota, Chieko Morimoto, Toshio Igarashi, Tomoyuki Fujii, Tetsu Yano, Yuji Taketani Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Japan

P-40. COMPLETE AND PARTIAL HYDATIDIFORM MOLE- DIAGNOSIS AND MANAGEMENT AT A BRAZILIAN

TERTIARY CARE CENTER Izildhina Maesta1), LRMG Delmanto1), JC Peracoli1), OC Michelin2), EGV Ferreira3), M Consonni1), FR Gaiotto4), MVC Rudge1) 1) Trophoblastic Diseases Center of the Department of Gynecology and Obstetrics, Botucatu Medical School- Sao Paulo

State University- UNESP, Brazil 2) Oncological Treatment Center of the Department of Internal Medicine, Botucatu Medical School- Sao Paulo State

University-UNESP, Brazil 3) Post-Graduation Program of Gynecology, Obstetrics and Mastology, Botucatu Medical School- Sao Paulo State

University-UNESP, Brazil 4) Graduation Botucatu Medical School- Sao Paulo State University-UNESP, Brazil


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P-41. COMPLETE HYDATIDIFORM MOLE WITH COEXISTING DICHORIONIC DIAMNIOTIC TWINS FOLLOWING TESTICULAR SPERM EXTRACTION AND INTRACYTOPLASMIC SPERM INJECTION(TESE-ICSI) M Kudo1), T Yamada1), T Yamada1), Y Ebina1), M Moriwaki1), S Nishi1), T Ohkouchi2), T Matsuda3), N Wake3), H Minakami1), N Sakuragi1) 1) Department of Obstetrics and Gynecology, Hokkaido University, Japan 2) Tabata Hospital, Japan 3) Department of Obstetrics and Gynecology, Kyushu University, Japan

P-42. ANTIGEN SPECIFIC T CELL IMMUNE RESPONSE DETECTED BY SKEWED T CELL RECEPTOR USAGE

IN NORMAL PLACENTA AND COMPLETE MOLE Zoltan Nagymanyoki1), M.J. Callahan1), M.M. Parast2), V. Fulop3) S.C. Mok1), R.S. Berkowitz1) 1) Laboratory of Gynecologic Oncology, Division of Gynecologic Oncology, Department of Obstetrics and Gynecology,

Brigham and Women’s Hospital, Boston, USA 2) Division of Women’s and Perinatal Pathology, Department of Pathology, Brigham and Women’s Hospital, Harvard

Medical School, Boston, MA, USA 3) Department of Obstetrics and Gynecology, State Health Center, Budapest, Hungary

P-43. INCREASED VASCULARIZATION AT THE IMPLANTATION SITE OF PERSISTENT PARTIAL AND

COMPLETE MOLAR PREGNANCY Zoltan Nagymanyoki1), M.M. Parast2), V. Fulop3), N. Horowitz1), S.C. Mok1), R.S. Berkowitz1) 1) Laboratory of Gynecologic Oncology, Division of Gynecologic Oncology, Department of Obstetrics and Gynecology,



P-44. OVEREXPRESSION OF LAMININ RECEPTOR 1 ON DECIDUAL CELLS IN PARTIAL AND COMPLETE

MOLE Zoltan Nagymanyoki1), M.J. Callahan1), M.M. Parast2), R.S. Berkowitz1), S.C. Mok1), V. Fulop3) 1) Laboratory of Gynecologic Oncology, Division of Gynecologic Oncology, Department of Obstetrics and Gynecology,



P-45. INCIDENCE OF MOLE IN ONE OF THE WESTERN CITY OF IRAN

Seyed Mohammad Hosseinipanah, Soudabeh Aghababaie, Ensieh Mohabikian, Farideh Amini Dept. Anatomy, Medical Faculty, Hamadan University of Medical Sciences.Hamadan-IRAN

P-46. EVALUATION OF CYTOTROPHOBLAST IN HUMAN PLACENTA DURING DEVELOPMENT OF HUMAN

EMBRYO AND COMPARE IT WITH HYDATIFORM MOLE AND CHORIOCARCINOMA BY AG-NOR TECHNIQUE. Seyed Mohammad Hosseinipanah, Nahid Anvary, Hossein Mahjoub Faezeh Moshayedi Dept. Anatomy, Medical Faculty, Hamadan University of Medical Sciences.Hamadan-IRAN

P-47. ASSOCIATION OF THE SER 128 ARG POLYMORPHISM IN NORMAL PREGNANCY AND HYDATIDIFORM

MOLE Seyed Mohammad Hosseinipanah, Marzieh Garakhaninejad, Mehrangize Zamani, Mehrdad Hajilooi, Hassein Mahjoub Dept. Anatomy, Medical Faculty, Hamadan University of Medical Sciences.Hamadan-IRAN


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P-48. ACCURACY OF MACROSCOPIC DIAGNOSIS IN THE CASE OF HYDATIDIFORM MOLE INCLUDING SMALL HYDOROPIC VILLI - DISCORDANCY FROM GENETIC DIAGNOSIS - Eisuke Kaneki1), Hiroaki Kobayashi1), Toshio Hirakawa2), Takao Matsuda3), Hidenori Kato4), Norio Wake1) 1) Department of Obstetrics and Gynecology, Kyusyu unversity hospital, Japan 2) Sanada clinic, Japan 3) Department of Gynecology, Nisibeppu national hospital, Japan 4) Department of Gynecology, National Hospital Organization Hokkaido Cancer Center, Japan

P-49. IS HUMAN CHORIONIC GONADOTROPHIN (HCG)-FREE β-SUBUNIT MEASUREMENT A SPECIFIC

MARKER OF PLACENTAL SITE TROPHOBLASTIC TUMOURS (PSTT)? Richard Alan Harvey UK Trophoblastic and Screening Service Centre, Charing Cross Hospital, London W6 8RF.

P-50. ULTRASONOGRAPHY AS A DIAGNOSTIC TOOL IN INVASIVE MOLE

Anwar AD1), Alamsyah M1), Harahap EH2), Martaadisoebrata D1) 1) Department of Obstetrics and Gynecology, Faculty of Medicine, Padjadjaran University, Hasan Sadikin Hospital

Bandung, Indonesia 2) Department of Obstetrics and Gynecology, Pertamina General Hospital Jakarta., Indonesia

P-51. A CASE OF MONOAMNIOTIC TWINS WITH TWO YOLK SACS ULTRA- SONOGRAPHICALLY DETECTED

IN EARLY FIRST TRIMESTER Tae Mogami1), Miyuki Ogawa1), Aiko Nonaka1), Yuka Ohi1), Aya Kadowaki1), Tetsuya Hasegawa1), Yoshiyuki Nomura1), Keisuke Saito1), Mika Okuda1), Tsuneo Takahashi1), Humiki Hirahara2) 1) Maternity And Neonate Center, Yokohama City University Medical Center 2) Depertment Of Obstetrics And Gynecology, Yokohama City University Hospital

P-52. WHAT DO WE THINK OF COMPLETE REMISSION? TWO CASES OF CHOLIOCARCINOMA WITH

RESIDUAL MASS AFTER TREATMENT. T. Sakamoto, S. Tanaka, T. Yamazaki, F. Inaba, T. Kamemori, N. Kosaka, K. Yamazawa, I. Fukasawa, N. Inaba Department of Obstetrics and Gynecology, Dokkyo Medical University School of Medicine, Japan

P-53. EARLY IDENTIFICATION OF POST-MOLAR TROPHOBLASTIC NEOPLASIA BY NORMAL HUMAN

CHORIONIC GONADOTROPIN (β-hCG) REGRESSION CURVE Izildhina Maesta1), LRMG Delmanto1), AR Braga1,4), OC Michelin2), JRS Passos3), FR Gaiotto1), MVC Rudge1) 1) Department of Gynecology and Obstetrics - Sao Paulo State University, UNESP, Botucatu/SP, Brazil 2) Department of Medical Clinic - Sao Paulo State University, UNESP, Botucatu/SP, Brazil 3) Department of Bioestatistic of Institute of Biociency - Sao Paulo State University, UNESP, Botucatu/SP, Brazil 4) 33th Enfermaria da Santa Casa de Misericordia do Rio de Janeiro, Rio de Janeiro-RJ

P-54. THE MEASUREMENTS OF SERUM HUMAN CHORIONIC GONADOTROPIN (hCG) IN PATIENTS WITH

GESTATIONAL TROPHOBLASTIC NEOPLASIA (GTN) USING WITH TWO DIFFERENT COMMERCIAL hCG KITS Hideo Matsui, Maki Kihara, Hirokazu Usui, Emiri Nakada, Shinnichi Tate, Akira Mitsuhashi, Makio Shozu Department of Reproductive Medicine, Chiba University Graduate School of Medicine, Japan

P-55 . RISING hCG-H in PERSISTENT LOW LEVEL hCG

Djamhoer Martaadisoebrata Dept of Obstetrics and Gynecology, Hasan Sadikin Hospital, Indonesia


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P-56. CLINICAL APPLICATIONS OF HCG-MRNA QUANTIFICATION IN CHORIOCARCINOMA Kentaro Yamasaki, Kiyonori Miura, Shoko Miura, Shingo Moriyama, Haruka Gunjigake, Hideaki Masuzaki Department of Obstetrics and Gynecology, School of Medicine, Nagasaki University, Japan

P-57. AMNIOTIC STEM CELLS FORM SPHEROID

N Yoneda1,2), M Okabe1), A Toda1), O Higuchi1), M Nogami1), R Nishiyama2), M Ito2), A Shiozaki2), T Yoshida1), S Saito2), T Nikaido1) 1) Department of Regenerative Medicine, University of Toyama Graduate School of medicine and Pharmaceutical

Sciences, Japan 2) Department of Obstetrics and Gynecology, University of Toyama Graduate School of medicine and Pharmaceutical

Sciences, Japan P-58. THE ROLE OF THORACOTOMY IN GESTATIONAL TROPHOBLASTIC DISEASE

Evelyn L. Fleming, L. Garrett, M. Callahan, S. Ghosh, N. Nevadunsky, D. Goldstein, R. Berkowitz The New England Trophoblastic Disease Center, Brigham and Womens Hospital, Harvard University, USA.

P-59. A CASE OF PLACENTAL MESENCHYMAL DYSPLASIA

Sreedevi Venugopal1), P. K. Sekharan1), S. Vinayachandran1), Smitha D Couth1), O. Rasheeda Beghum1), C. H. Mini1), Meera Pavithran1) Medical College, Calicut, Kerala, India

P-60. THE FETAL GROWTH RESTRICTION CAUSED BY MATERNAL UNDERNUTRITION IS AMELIORATED BY

BRANCHED-CHAIN AMINO ACIDS-SUPPLEMENTED DIET Haruta Mogami1), Shigeo Yura1), Hiroaki Itoh2), Tsuyoshi Fujii1), Makoto Kawamura1), Norimasa Sagawa3), Shingo Fujii4) 1) Kyoto University Graduate School of Medicine, Japan 2) Osaka Medical Center, Japan 3) Mie University Graduate School of Medicine, Japan 4) Kyoto Medical Center, Japan

P-61. DIFFERENT CHANGES IN RESISTANCE INDEX BETWEEN UTERINE ARTERY AND UTERINE RADIAL

ARTERY DURING EARLY PREGNANCY Isao Tamura, Hiroshi Tamura, Ken Taniguchi, Ryo Maekawa, Hiromi Asada, Toshiaki Taketani, Aki Matsuoka, Yoshiaki Yamagata, Norihiro Sugino Department of Obstetrics and Gynecology, Yamaguchi University Graduate School of Medicine, Japan

P-62. PLACENTAL REGULATION OF MATERNAL MELATONIN PRODUCTION IN PREGNANT RATS

Tosiaki Taketani, Hiroshi Tamura, Isao Tamura, Ken Taniguchi, Ryo Maekawa, Hiromi Asada, Aki Matsuoka, Yoshiaki Yamagata, Norihiro Sugino Department of Obstetrics and Gynecology, Yamaguchi University Graduate School of Medicine, Japan

P-63. SERIOUS BIPOLAR DEPRESSION AMALGAMATION PREGNANCY WITH SEVERE IUGR WOULD BE

CAUSED BY PLACENTA THROMBUS FORMATION AFTER ECT REPEATING ITSELF Takashi Yamada1), Rintaro Sawa1), Hiroko Abe1), Fumi Kikuti1), Katsuya Mine1), Gen Ishikawa1), Tetsuya Ichimiya2), Yoshiro Okubo2), Toshiyuki Takeshita1) 1) Department of Obstetrics and Gynecology, Nippon Medical School, Japan 2) Department of Neuropsychiatry, Nippon Medical School, Japan


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P-64. RESIDUAL OF EXTRAEMBRYONIC COELOM CYST: CASE REPORT Seiji Sumigama, Hiromi Hayakawa, Fumitaka Kawachi, Masae Hironaka, Akiko Morimitsu, Yukio Mano, Nanako Sato, Masako Araki, Fumitaka Kikkawa Nagoya University Graduate School of Medicine, Department of Obstetrics and Gynecology, Japan

P-65. SUBCELLULAR DISTRIBUTION OF IGG AND ALBUMIN IN THE FIRST-TRIMESTER HUMAN PLACENTA

AS REVEALED BY ULTRAHIGH-RESOLUTION IMMUNOFLURECENCE MICROSCOPY Gen Ishikawa1), Miki Mori2), Shan-Shun Luo2), Tomoko Ishikawa2), Takuya Mishima2), Toshiyuki Takeshita1), Toshihiro Takizawa2) 1) Department of Obstetrics and Gynecology, Nippon Medical School, Tokyo, Japan 2) Department of Molecular Anatomy and Medicine, Nippon Medical School, Tokyo, Japan

P-66. EXPRESSION OF FC GAMMA RECEPTORS ON HUMAN PLACENTAL HOFBAUER CELLS

Toshihiro Takizawa1), Gotaro Kurasawa1), Miki Mori1), Gen Ishikawa2), Osamu Ishibashi1), Takuya Mishima1), Tomoko Ishikawa1), Shan-Shun Luo1), Takami Takizawa1), Tadashi Goto1), Toshiyuki Takeshita2) 1) Department of Molecular Anatomy and Medicine, Nippon Medical School, Tokyo, Japan 2) Department of Obstetrics and Gynecology, Nippon Medical School, Tokyo, Japan

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