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Physical Sciences Inc. 20 New England Business Center Andover, MA 01810

PhysicalSciences Inc. VG10-182

Biomedical Optics InstrumentationDan Hammer, Dan Ferguson, Nick Iftimia, Dave Rosen

Physical Sciences Inc.

A Case Study for University – Industry Collaborationpresented by Mark Druy and B. David Green at the

Session on SBIR Successes at

2010 National SBIR Beyond Phase IIConference and Technology Showcase

15 September 2010

Physical Sciences Inc.VG10-182-1

Who we are

A growing 37 year-old company of 180 scientists, engineers and administrative professionals

Headquartered in Andover, MA; operations in:– Pleasanton, CA (PSI)– Lanham, MD and Princeton, NJ (RSI)– Bedford, MA (Q-Peak)– Dayton, OH (Faraday Technology)– College Park, MD (Maxion Technologies)

Research Support Instruments supports the Naval Research Laboratory and National programs

Q-Peak manufactures lasers and optical devices

Faraday Technology develops electrochemical processing

Maxion Technologies develops long-wavelength (3-12 microns) infrared semiconductor lasers

PSI is a technologically diverse research and development organization with revenues of $50+M

Owned by the PSI Employee Stock Ownership Trust


Our Locations

Lanham, MD

Systems Supportand Calibration

RSI

Princeton, NJ

MEMS and PlasmaTechnologies

RSI

Bedford, MA

Solid State Lasers

Q-Peak

Andover, MACorporate Headquarters

PSI Main Offices

Material Sciences and Technologies,Optics and Laser Technologies,Space and Atmospheric Studies,

Energy TechnologiesPleasanton, CA

Space ExplorationTechnologies andNovel Electro-optic

Materials

PSI

C-7543

Clayton, OH

Pulsed/Pulse ReverseElectrochemical Engineering

for Precise Surface Modification

Faraday Technology, Inc.

Haverhill, MA

Advanced CompositeStructures

PSI

Maxion Technologies, Inc.

Quantum and InterbandCascade Lasers

IR EO Materials and Devices

College Park, MD


Creating Value For Our Customers

Leading edge technology invention, development, and application

Custom instrument development

Prototype product development, premanufacturing, and technology transfer

Production of specialized instruments

Technology and product licensing to strategic partners and spin-outs


Army, Air Force, and NIH SBIR/STTRFunding has led to

Rapid assessment tool for retinal damage from laser illumination Tools for angiography and guided surgery in the eye Biomedical optical systems for ophthalmic researchers, clinicians, and

other medical personnel– Detection of diseases– Discovery of novel therapies– Understanding of the body from system/organ to sub-cellular and molecular structures

PSI (small business) creating improved diagnostic instrumentation – Eye diseases, eye health, drug discovery

University – Teaching hospital – Industry collaborative research– Publications motivating additional research by many groups around world

Sale of advanced instrumentation to leading research labs Licensing of technology to leading established OCT manufacturer

– Wide spread application in clinics and laboratories

Licensing of enabling technology to several focused start up companies– Many formed from university labs


Ophthalmic Diagnostics

Ophthalmic Instrumentation– TSO: Tracking, Scanning Ophthalmoscope– TOCT: Tracking Optical Coherence Tomography– LSO: Line Scanning Ophthalmoscope– AOSLO: Adaptive Optics Scanning Laser Ophthalmoscope

Applications– Laser illumination damage and mechanisms– Diagnosis and surgical guidance in the eye– Degenerative eye diseases in children and aged

• Diabetic retinopathy, macular degeneration– Research on the cellular basis of eye diseases


Biomedical Imaging Instruments

Line scanning ophthalmoscopy (LSO)– Compact retinal imager to augment or guide OCT

• Autofluorescence, microperimetry• Small animal imaging and advanced therapies

– patents– 5 licenses with ophthalmic instrument manufacturers

Retinal tracking (TOCT)– High-speed, high fidelity stabilization of eye motion– Applications: AO, SDOCT, PSOCT, hemodynamics– Diagnostic or therapeutic beams– > 12 systems sold to researchers– patents

Adaptive optics (AOSLO)– Measurement and correction of ocular aberrations– Ultrahigh resolution of retinal structures– patent applications

Real-time Fourier domain OCT processor


Collaborators

Including:

Bruce Stuck Henry Hacker Ben Rockwell David R. Williams Benjamin Bloom T. Milner Robb Webb Ann Elsner Steve Burns Johannes F. de Boer Joel Schuman

Institutions:

Army Medical Research Branch Air Force Research Lab HPW, Brooks Schepens Eye Research Institute Mass Eye and Ear Infirmary MIT University of Pittsburgh University of Rochester University of Texas, Austin Indiana University Massachusetts General Hospital Boston Medical Center Brigham and Women’s Hospital University of Texas Medical Branch


Representative Journal Publications

Applied Optics: Compact Scanning Laser Ophthalmoscope with High-Speed Retinal Tracker

Optics Express: Image Stabilization for Scanning Laser Ophthalmoscope

Journal of Biomedical Optics: An Active Retinal Tracker for Clinical Optical Coherence Tomography Systems

Optics Express: Advanced Scanning Methods with Tracking Optical Coherence Tomography

Journal of Biomedical Optics:Scanning Laser Opthalmoscope

Optics Express: Wide-field hemodynamic imaging with tracking ophthalmoscope

Optics Express: Adaptive optics scanning laser ophthalmoscope for stabilized retinal imaging

Journal of the Optical Society of America: Increased Signal and Resolution with Adaptive Optics Spectral Domain Optical Coherence Tomography

Optics Express: Hybrid retinal imager using linescanning laser ophthalmoscopy and spectral domain optical coherence tomography

Optics Letters: Tracking OCT Optics Express: Dual-beam Fourier

domain optical Doppler tomography of zebrafish

Circulation Research: Blood flow and cardiac output measurements in zebrafish (Danio rerio) using dual-beam Fourier domain optical Doppler tomography

Review Scientific Instruments: Real-time processing for Fourier domain optical coherence tomography using a field programmable gate array

Optics Express: Compact adaptive optics line scanning Ophthalmoscope

Journal of the Optical Society of America A: Adaptive optics SLO with integrated wide-field retinal imaging and tracking


Licenses: Tracking for Ophthalmic Office Market

Partner with major instrument company – Non exclusive license

– Transfer technology

– Work with development team to incorporate in Gen 4 product

Benefit– Provides high contrast, wide area image of retina

– Ensures precise registration between OCT scan and fundus image

Adds incremental cost to product – Significantly greater value

Sold 5940 units in 27 months

PSI receives modest royalty income


Custom Instrument Sales to Researchers

Licenses to start up companies – commercial product creation– retinal metabolic analysis– perimetry– therapeutics (pending)– small animal imaging– OCT, optical biometer

Custom ophthalmic instruments for researchers at:

– U. Rochester– Indiana U.– U. Texas Medical Branch– U. Texas Austin– Harvard– MIT– U. Pittsburgh Medical Center– Mass General Hospital– Children’s Hospital/Boston– U. Michigan– U. Waterloo– FDA


Summary

Under Air Force, Army, and NIH SBIR /STTR funding PSI staff has: – Performed world class research in the understanding and diagnosis of

diseases of the eye– Collaborated with many researchers in academia – Published and presented results to community to spur additional research– Obtained six patents– Developed several generations of optical diagnostic technology– Standardized subassemblies and process in a Prototype Manufacturing Area– Offered specialized instruments and sold them to the research community– Created further collaborations and advanced research by the community

Licensing several generations of the technology to companies for commercial products– Established commercial company next product for wide application in clinics – Start up companies for autofluorescence, low cost retinal screening,

image-guided therapy• Many grow and evolve from university laboratories


University – PSI Partnerships in Last Five Years

Alfred University Michigan Tech University University of IllinoisBoston University MIT University of MichiganBrown University Northeastern University University of MarylandCalifornia State University Ohio State University University of New HampshireCornell University Pennsylvania State University University of North CarolinaDartmouth College Princeton University University of Notre DameDuke University State University of New York University of PittsburgEmory University UMass Lowell University of RochesterHarvard University University of Arizona University of TexasIndiana University University of Connecticut Utah State UniversityIowa State University of Deleware Western New England CollegeJohns Hopkins University University of Denver West Virginia UniversityMedical College of Wisconsin University of Florida Worcester Polytechnic Institute

biomedical optics instrumentation - psicorp.com · biomedical optical systems for ophthalmic...

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