association for academic surgery 34th annual meeting
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SCIENTIFIC PROGRAM
Association for Academic Surgery34th Annual Meeting
Journal of Surgical Research 93, 293–305 (2000)doi:10.1006/jsre.2000.5993, available online at http://www.idealibrary.com on
Tampa, Florida, November 2–4, 2000
THURSDAY, NOVEMBER 2, 2000
9:00 am–6:00 pm RegistrationGalleria A
10:00 am–12:00 pm President’s WorkshopRegency I–IVDavid I. Soybel, M.D.
“Perspectives on the Restructuring ofNIH Study Sections”Ellie Ehrenfeld, Ph.D.NIH Center for Scientific Review
Arthur Rubenstein, MBBChDean, Mount Sinai School of Medicine
Samuel A. Wells, Jr., M.D.American College of Surgeons
James C. Thompson, M.D.University of Texas Medical Branch
12:00 pm–1:00 pm Lunch (on own)
1:00 pm–3:30 pm Plenary SessionRegency Ballroom I–IVModerator: David I. Soybel, M.D.
1. Identification of SURF2, a Ubiquitin E3 Ligase for TGF-bSignal Transducer SMAD2/3. X. Lin, Ph.D., X. H. Feng,Ph.D., Baylor College of Medicine, Houston, TX
2. Evidence for Receptor-Mediated Signaling by Sphin-gosine 1-Phosphate in Enteric Glia. B. J. Segura, M.D.,R. A. Cowles, M.D., L. Xiao, M.D., M. W. Mulholland, M.D.,Ph.D., University of Michigan Medical Center, Ann Arbor, MI
3. Tumor Cell Adhesion to Endothelial Cells Is Increasedby Endotoxin via an Upregulation of b-1 Integrin Expres-sion. E. J. Andrews, M.B., B.Ch., D. C. Winter, M.D., J. H.Wang, Ph.D., W. E. Laug, M.D., and H. P. Redmond, M.Ch.,Cork University Hospital, Cork, Ireland/Childrens’ Hospital ofLos Angeles, Los Angeles, CA
4. Modified AdCTLA4 Vector Blocks Alloimmune Response
in Vitro. G. Zamir, M.D., A. E. Gelman, B.S., X. Que, M.D., X.Aldeguer, M.D., F. Debonera, B.A., A. Shaked, M.D., and K. M.Olthoff, M.D. University of Pennsylvania, Philadelphia, PA293
5. Factors Affecting Choice of Surgical Residency TrainingProgram between Men and Women. K. L. Mayer, M.D.,R. V. Perez, M.D., and H. S. Ho, M.D., UC Davis School ofMedicine, Sacramento, CA
6. Identification of Regulatory Elements in the Distal Pro-moter Region of the Clara Cell Secretory Protein Gene.A. S. Y. Chang, M.D., P. L. Ramsay, M.D., M. J. Reardon, M.D.,and F. J. DeMayo, Ph.D., Baylor College of Medicine, Houston,TX
7. Voltage-Gated Potassium (Kv) Channel Blockade BluntsOxygen-Induced Vasodilation in Pulmonary Arteriolesfrom Term Fetal Rats. J. R. Gosche, M.D., Yale UniversitySchool of Medicine, New Haven, CT
8. Transforming Growth Factor b2 Lowers the Incidence ofIncisional Hernias. M. G. Franz, M.D., M. A. Kuhn, M.D., K.Nguyen, B.S., X. Wang, M.D., Ph.D., F. Ko, B.S., T. E. Wright,M.D., FACS, and M. C. Robson, M.D., University South Florida,Tampa, FL/Bay Pines VAMC, Bay Pines, FL
9. Pharmacological Induction of HSP 27 Attenuates Inti-mal Hyperplasia in Vivo. E. M. Connolly, FRCSI, C. J. Kelly,FRCSI, C. Gang, M.B., T. O’Grady, Bsc., E. Kay, FRCPath, A.Leahy, FRCSI, Mch., and D. J. Bouchier-Hayes, FRCSI, Mch.,Royal College of Surgeons & Beaumont Hospital, Dublin, Ire-land
10. Mitochondrial Reactive Oxygen Species: A Link betweenEndothelial Hypoxia and IL-6 Production. D. P. Pearl-stein, M.D., M. H. Ali, B.A., and P. T. Schumacker, Ph.D.,University of Illinois at Chicago Metropolitan Group Hospitals/The University of Chicago, Chicago, IL
3:30 pm–4:00 pm
Refreshment BreakGalleria B2-3
3:30 pm
Authors to Set Up PostersGalleria B-1
0022-4804/00 $35.00Copyright © 2000 by Academic Press
All rights of reproduction in any form reserved.
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4:00 pm–5:15 pm
Committee on IssuesRegency Ballroom I–IV
“Maturation in Academic Surgery: From Assistant to As-sociate and Beyond”Chairman: Michael S. Conte, M.D.
Michael J. Zinner, M.D.Junior Faculty Development in the Current Healthcare Envi-ronment: Chairman’s Perspective
Steven F. Lowry, M.D.Nurturing the Academic Enterprise in Junior Surgical Faculty
Barbara L. Bass, M.D.Maintaining Job Satisfaction and Personal Growth in JuniorSurgical Faculty
5:15 pm–6:15 pm
Nominating Committee MeetingYbor Room
Evening Free
FRIDAY, NOVEMBER 3, 2000
6:30 am–7:30 am
Continental Breakfast/View PostersGalleria B2-3
6:30 am–5:00 pm
RegistrationGalleria A
7:30 am–9:30 am
Parallel Session ICLINICAL TRIALS AND OUTCOMESBuccaneer BModerators: William E. Fisher, M.D.
Seema S. Sonnad, Ph.D.
11. Long-Term Outcomes of the Ileal Pouch Anal Anastomo-sis: The Effect of Bowel Function on Quality of Life 5Years after Surgery. C. Y. Ko, M.D., L. C. Rusin, M.D., D. J.Schoetz, Jr., M.D., L. Moreau, M.D., J. C. Coller, M.D., J. J.Murray, M.D., and P. L. Roberts, M.D., UCLA Medical Center,Los Angeles, CA, and Lahey Clinic, Burlington, MA
12. Modified “Israeli” Repair Using Polypropylene Mesh On-lay for Treatment of Complicated Incisional Hernias.K. G. Chisholm, M.D., and S. R. Schell, M.D., Ph.D., Universityof Florida/Malcolm Randall Veterans Affairs Hospital, Gaines-ville, FL
13. Predictors of Myocardial Recovery in Patients with Ven-tricular Assist Devices. B. A. Bruckner, M.D., S. J. Stetson,B.S., P. Razeghi, M.D., G. P. Noon, M.D., M. L. Entman, M.D., G.Torre-Amione, M.D., O. H. Frazier, M.D., K. A. Youker, Ph.D.,Baylor College of Medicine/Texas Heart Institute, Houston, TX
294 SCIENTIFI
14. Women Have Higher Operative Mortality after CoronaryArtery Bypass Surgery: Is It Sex or Something Else? R. H.Chen, M.D., Ph.D., A. Kadner, M.D., J. G. Byrne, M.D., L.
Aklog, M.D., D. H. Adams, M.D., Brigham and Womens’Hospital/Harvard Medical School, Boston, MA
15. Impact of Gender, Age, and Functional Capacity onFunctional Outcome Following CABG. R. D. Stewart,M.D., N. C. Namour, B.A., E. Dziadik, B.A., S. Levitsky, M.D.,and C. T. Campos, M.D., Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA
16. Learning Curves for Breast Cancer Lymphatic Mapping:Institutional Volume Index. E. L. Dupont, M.D., C. E. Cox,M.D., S. Shivers, Ph.D., C. J. Salud, B.A., K. Nguyen, B.S., A.Cantor, Ph.D., and D. S. Reintgen, M.D., University of SouthFlorida, Tampa, FL
17. Racial Differences in Breast Cancer Survival: The Effectof Residual Disease. A. T. Mancino, M.D., R. Landes, M.S.,R. H. Tillman, M.D., L. F. Smith, M.D., H. J. Spencer, M.S., L.Erkman, C.T.R., I. T. Rubio, M.D., and V. S. Klimberg, M.D.,University of Arkansas, Little Rock, AR
18. Early Results Of Breast Cancer Lymphatic Mapping: NoAxillary Recurrence In Breast Cancer Patients After ANegative Sentinel Lymph Node Biopsy. S. Dessureault,M.D., E. Dupont, M.D., A. Shons, M.D., C. Berman, M.D., N.Ku, M.D., C. Cox, M.D., and D. S. Reintgen, M.D., H. LeeMoffitt Cancer Center and Research Institute at the Universityof South Florida, Tampa, FL
:30 am–9:30 am
Parallel Session IPERIPHERAL VASCULAR IBuccaneer C/DModerators: Robert A. Cambria, M.D.
Gary B. Nackman, M.D.
19. Contraction-Coupled Nitric Oxide Release: A New Para-digm for Local Vascular Control? H. W. Kim, Ph.D., andA. G. Greenburg, M.D., Ph.D., Brown University/The MiriamHospital, Providence, RI
20. Shear and Strain Mediate Aortic Enlargement FollowingAVF Creation. J. K. Karwowski, M.D., C. C. Yeh, B.S., andR. L. Dalman, M.D., Stanford University School of Medicine,Stanford, CA
21. Oscillatory Flow Induces DNA Synthesis in EndothelialCells and Requires Distinct Signaling to a TranslationalControl Pathway. L. W. Kraiss, M.D., T. M. Ennis, M.S., T. M.McIntyre, Ph.D., and G. A. Zimmerman, M.D., University ofUtah, Salt Lake City, UT
22. Upregulation of Intrarenal and Adrenal Angiotensin II(AII) Production in Chronic Renovascular Hypertension(RVH). J. G. Modrall, M.D., K. Puttaparthi, Ph.D., G. P.Clagett, M.D., R. H. Turnage, M.D., and M. Levi, M.D., Uni-versity of Texas Southwestern Medical Center, Dallas, TX
23. Liposome-Mediated Gene Delivery to Endothelial Cellsto Prevent and Treat Thrombosis. R. R. Dickason, M.D.,Ph.D., A. B. Weinfeld, M.D., S. Almohammed, M.D., A. M.Amer, Ph.D., E. Yuksel, M.D., M. Kattash, M.D., and S. M.Shenaq, M.D., Baylor College of Medicine, Houston, TX
24. Gene Delivery to Veins Using Adeno-Associated (AAV)
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Viral Vectors: Long-Term Expression with Minimal HostResponse. K. K. Rhynhart, M.D., S. P. Gangadharan, M.D.,R. O. Snyder, Ph.D., X. X. Sui, M.D., and M. S. Conte, M.D.,
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Brigham and Womens’ Hospital and the Harvard Institute forHuman Genetics, Boston, MA
25. Adenoviral-Mediated Uteroglobin Gene Transfer to theAdventitia Reduces Arterial Intimal Hyperplasia. J. V.Lombardi, M.D., M. Naji, R. A. Larson, M.D., A. Naji, M.D.,Ph.D., B. Koeberlein, and M. A. Golden, M.D., Hospital of theUniversity of Pennsylvania, Philadelphia, PA
26. Accuracy of Intravascular Ultrasound (IVUS) and Quanti-tative Angiography (QA) for Diameter Measurement ofPhantom Arterial Models. B. Z. Cooper, M.D., M. Cooper, Esq.,J. A. Ramirez, M.D., J. G. Najjar, M.D., S. B. Blattman, M.D., M.Song, M.D., J. D. Kirwin, M.D., W. Rodino, M.D., and T. F. Pan-etta, M.D., SUNY Downstate Medical Center, Brooklyn, NY
:30 am–9:30 am
Parallel Session IMETABOLISM, ENDOCRINOLOGY, AND NUTRITIONEsplanade I–IIModerators: Mark A. Wilson, M.D.
A. James Moser, M.D.
27. Granulation Tissue Apoptosis Induced by a Musculocu-taneous Flap. M. A. Carlson, M.D., and B. T. Baxter, M.D.,University of Nebraska Medical Center, Omaha, NE
28. Systemic Heat Shock Attenuates the NeuroendocrineResponse to Surgical Stress in Rats. B. B. O’Neill, M.D., S.Sheen-Chen, M.D., W. J. Welch, Ph.D., H. W. Harris, M.D.,UCSF Surgical Research Lab at SFGH, San Francisco, CA
29. Imidazole Blockade of Cortisol Synthesis in Burn Pa-tients. D. W. Hart, M.D., S. E. Wolf, M.D., A. A. Ferrando,Ph.D., C. G. Wigginton, B.S., R. R. Wolfe, Ph.D., and D. N.Herndon, M.D., The Shriner’s Hospitals for Children and TheUniversity of Texas Medical Branch, Galveston, TX
30. Lack of Enteral Nutrition Increases Gut Expression ofE-Selectin but Not ICAM-1 after Lipopolysaccharide(LPS) Challenge. K. Fukatsu, M.D., B. L. Zarzaur, M.D., C. D.Johnson, Ph.D., A. H. Lundberg, M.D., M. K. Hanna, M.D.,H. G. Wilcox, Ph.D., and K. A. Kudsk, M.D., The University ofTennessee, Memphis, TN
31. Trophic Feeds Increase Hepatic Glutathione (GSH) Con-centration during Parenteral Nutrition. A. Dzakovic,M.D., O. Eshach-Adiv, M.D., A. Rhodes, B.S., P. R. Ling, M.D.,Y. M. Yu, M.D., B. Bistrian, M.D., and T. Jaksic, M.D., Child-rens’ Hospital, Beth Israel/Deaconess Hospital, MassachusettsGeneral Hospital, Harvard Medical School, Boston, MA
32. Role of Polyamine Biosynthesis in Burn-Induced SmallIntestinal Apoptosis. V. L. Chappell, M.D., D. H. Chung,M.D., S. E. Wolf, M.D., and J. C. Thompson, M.D., The Univer-sity of Texas Medical Branch and Shriners Burns Hospital,Galveston, TX
33. Eicosapentanoic Acid (EPA) Inhibits Tumor Growth andReduces Vascular Endothelial Growth Factor-a(VEGF-a) Expression. R. Tevar, B.S., T. Babcock, M.S., D.Jho, B.S., W. S. Helton, M.D., and N. J. Espat, M.D., Universityof Illinois, Chicago, IL
34. Antiproliferative Effects of a Novel SERM GW7604 onBreast and Endometrial Cells. D. J. Bentrem, M.D., R. Dardes,
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M.D., J. MacGregor Schafer, Ph.D., J. Zapf, Ph.D., and V. C.Jordan, Ph.D., D.Sc., Northwestern University Medical School,Chicago, IL, and Signal Pharmaceuticals, San Diego, CA
:30 am–9:30 am
Parallel Session IGASTROINTESTINAL IEsplanade IIIModerators: Diane M. Simeone, M.D.
James G. Norman, M.D.
35. Cerulein-Induced Acute Pancreatitis Is More Severe inMice Heterozygous for the DF508 Cystic Fibrosis Trans-membrane Conductance Regulator Gene Mutation ThanWild-Type Controls. Q. Liu, M.D., H. Fischer, Ph.D., W. J.Welch, Ph.D., and H. W. Harris, M.D., UCSF Surgical ResearchLab at SFGH, San Francisco, CA
36. Activation of the Capsaicin Receptor, VanilloidReceptor-1 (VR-1), Promotes Neurogenic Inflammationin Cerulein-Induced Pancreatitis. M. M. Hutter, M.D., J.Maa, M.D., E. C. Zerega, E. F. Grady, Ph.D., S. J. Mulvihill,M.D., N. W. Bunnett, Ph.D., and K. S. Kirkwood, M.D., Uni-versity of California, San Francisco, CA
37. The Role of NF-kB and IkB in Cytokine-Mediated Pulmo-nary Injury during Acute Pancreatitis. C. Jaffray, M.D., J.Yang, M.D., M. Murr, M.D., C. Mendez, M.D., and J. G. Nor-man, M.D., University of South Florida, Tampa, FL
38. Iron Deficiency Transiently Suppresses Biliary Neuro-nal Nitric Oxide Synthase. M. I. Goldblatt, M.D., D. A.Swartz-Basile, Ph.D., S. Choi, M.D., P. Rafiee, Ph.D., A. Na-keeb, M.D., S. K. Sarna, Ph.D., and H. A. Pitt, M.D., MedicalCollege of Wisconsin, Milwaukee, WI
39. Bicarbonate Secretion by Isolated Pancreatic Duct Cells Isa Metabolically Active Process. J. P. Regan, M.D., C. Alvarez,M.D., Department of Surgery, University of Maryland, Baltimore,MD, and UMDNJ–NJMS and East Orange VAMC, NJ
40. Anti-Vascular Endothelial Growth Factor AttenuatesPeritoneal Adhesion Formation. S. Sookhai, FRCSI, J.Wang, Ph.D., K. Austin, AFRCSI, D. Maguire, FRCSI, R. Cahil,AFRCSI, W. Kirwan, FRCSI, and H. P. Redmond, FRCSI., CorkUniversity Hospital, Cork, Ireland
41. Cholestasis Induces Murine Hepatocyte Apoptosis andDNA Synthesis with Preservation of the ImmediateEarly Gene Response. M. A. Bird, M.D., L. W. Schrum, Ph.D.,R. A. Rippe, Ph.D., D. A. Brenner, M.D., and K. E. Behrns,M.D., University of Carolina at Chapel Hill, Chapel Hill, NC
42. Bile Acid Stimulates Intestinal Epithelial Cell Migrationthrough Increased TGFb Expression. E. D. Strauch, M.D.,J. Y. Wang, Ph.D., K. Lally, M.S., and B. L. Bass, M.D., Uni-versity of Maryland, Baltimore, MD
:30 am–10:00 am
Refreshments/Poster ViewingGalleria B2-3
10:00am–11:00am
Founder’s LectureRegency Ballroom I–IV
“The Trouble with Fat”
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Michael S. Brown, M.D.Professor of Biophysics and Molecular Genetics,
University of Texas Southwestern Medical School, Dallas, Texas
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11:00 am–12:00 pm
Local ProgramRegency Ballroom I–IV
12:00 pm–1:00 pm
LuncheonRegency V–VII
1:00 pm–2:15 pm
Resident Research AwardsRegency Ballroom I–IV
U.S. Surgical Research Fellowship SummaryDaniel Kresiel, M.D.
43. Endotoxin (LPS) Stimulates PHAS-1 Phosphorylation inMacrophages. M. W. Potter, M.D., K. K. Elbirt, Ph.D., S. A.Shah, M.D., K. R. Sheth, M.D., and M. P. Callery, M.D., FACS,University of Massachusetts Medical School, Worcester, MA
44. Mechanism of Inhibition of Smooth Muscle Cell Migra-tion by Dexamethasone. C. Pross, M.D., M. M. Farooq, M.D.,N. Angle, M.D., J. A. Freischlag, M.D., H. A. Gelabert, M.D.,UCLA Medical Center, Los Angeles, CA
45. b-Catenin Antisense Oligonucleotide Treatment of Hu-man APC Mutant Colon Cancer Bearing Mice DecreasesTumor Growth Rate. D. W. Green, M.D., H. Roh, Ph.D., J.Pippin, B.S., and J. A. Drebin, M.D., Ph.D., Washington Uni-versity School of Medicine St. Louis, MO
:15 pm–3:30pm
Committee on EducationRegency Ballroom I–IV
“The Road Ahead”Chairman: Edward M. Barksdale, Jr., M.D.
David A. Geller, M.D.Choosing the Path and Getting Started
David L. Dunn, M.D.Crossroads
Ori D. Rotstein, M.D.Ditch or Dead-End
F. Charles Brunicardi, M.D.The Highroad
3:30 pm–4:00 pm
Refreshments/Poster ViewingGalleria B2-3
4:00 pm–6:00 pm
Parallel Session IIONCOLOGY IBuccaneer BModerators: David M. Euhus, M.D.
296 SCIENTIFI
Peter Shamamian, M.D.
46. Epithelial Cyclooxygenase-2 (COX-2) Expression in Re-sponse to Environmental Stress: A Model for Pathogen-
esis of Colon Cancer. S. Arbabi, M.D., M. R. Rosengart, M.D.,I. Garcia, B.A., and R. V. Maier, M.D., University of Washing-ton, Seattle, WA
47. Transcriptional Cofactor p300/CBP-Associated Factor(PCAF) Interacts with Smad3 to Mediate TGF-b-InducedTranscription. X. H. Feng, Ph.D., and X. Lin, Ph.D., BaylorCollege of Medicine, Houston, TX
48. Mechanism of TGF-b Growth Inhibition in a Rodent Pan-creatic Islet Cell Line. S. S. Guo, M.D., X. Wu, M.D., Ph.D.,and M. P. Sawicki, M.D., VAMC-WLA and UCLA School ofMedicine, Los Angeles, CA
49. p63 Compensates for the Functional Loss of the TumorSuppressor Gene p53. Y. Suliman, M.D., O. Opitz, M.D., N.Williams, M.D., FRCSI, and A. K. Rustgi, M.D., University ofPennsylvania, Philadelphia, PA
50. FRAP-p70s6K Signaling Is Required for Pancreatic Can-cer Cell Proliferation. S. A. Shah, M.D., M. W. Potter, M.D.,R. Ricciardi, M.D., R. A. Perugini, M.D., and M. P. Callery,M.D., FACS, University of Massachusetts Medical School,Worcester, MA
51. Growth of B16F10 Melanoma Tumors Requires uPa-Producing Host Cells. K. A. Joseph, M.D, N. Chuang, M.D.,R. Shapiro, M.D., and P. Shamamian, M.D., New York Univer-sity School of Medicine, New York, NY
52. NT4 Upregulates HLA, TAP, and HsP-70 Expression inNeuroendocrine Tumors Possibly via the Induction ofRFX-B and RBP-Jk: A Potential New Class of Immuno-modulatory Drugs. I. Avital, M.D., D. Inderbitzin, M.D., D.Tyan, Ph.D., A. T. Lefor, M.D., and W. Arnaout, M.D., Cedars-Sinai Medical Center and UCLA School of Medicine, Los Ange-les, CA
53. Cytosolic Phospholipase A2 (CPLA2)-Mediated ICAM-1Expression Is Calcium Dependent. C. C. Barnett, Jr., M.D.,E. E. Moore, M.D., C. C. Silliman, M.D., Ph.D., E. K. Abdalla,M.D., D. A. Partrick, M.D., and S. A. Curley, M.D., Universityof Texas and MD Anderson Cancer Center, Houston, TX andUniversity of Colorado, Denver, CO
:00 pm–6:00 pm
Parallel Session IIPEDIATRICSBuccaneer C/DModerators: Mike Kuang-Sing Chen, M.D.
Dai H. Chung, M.D.
54. Novel Effect of Leptin on Small Intestinal AbsorptiveCapacity after Massive Small Bowel Resection. P. Y. Pear-son, M.D., and M. Z. Schwartz, M.D., A.I. duPont Hospital forChildren, Wilmington, DE, and Thomas Jefferson University,Philadelphia, PA
55. Epithelial Cell Permeability Is Not Increased by Serumfrom Mice Following Massive Small Bowel Resection.D. P. O’Brien, M.D., L. E. Stern, M.D., C. R. Erwin, Ph.D., andB. W. Warner, M.D., Children’s Hospital Medical Center/University of Cincinnati College of Medicine, Cincinnati, OH
56. Effect of Hypoxia on Fetal Gastrointestinal Motility. M.
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Sase, M.D., J. J. Lee, M.D., M. J. Ross, M.D., and T. L.Buchmiller-Crair, M.D., Harbor–UCLA Medical Center, Tor-rance, CA
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57. Vascular Endothelial Growth Factor Is Upregulated inNeuroblastoma and Hepatocyte Cocultures. E. A. Beierle,M.D., L. F. Strande, M.S., M. Kuang-Sing Chen, M.D., UMDNJ,Camden, NJ
58. Role of Cellular Mechanics in Lung Branching Morpho-genesis. K. A. Moore, M.D., Y. Kong, M.D., Ph.D., S. Huang,M.D., Ph.D., M. E. Sunday, M.D., Ph.D., and D. E. Ingber, M.D.,Ph.D., Children’s Hospital and Harvard Medical School, Bos-ton, MA
59. Repetitive Electrical Stimulation of a Rectus AbdominisMuscle Detrusor Myoplasty Produces More EfficientBladder Evacuation. G. A. Perez-Abadia, M.D., J. G. VanSavage, M.D., J. W. Bardoel, M.D., T. G. Harralson, B.S., L. G.Palanca, M.D., M. M. Palacio, M.D., C. J. Maldonado, Ph.D.,J. I. Harty, M.D., G. R. Tobin, M.D., and J. H. Barker, M.D.,Ph.D., University of Louisville, Louisville, KY
60. Bone Marrow Tissue Engineering for Treatment of Con-genital Hematopoietic Disorders. A. S. Krupnick, M.D., A.Shaaban, M.D., S. Hayashi, S. Bouchard, M.D., T. Saydam,M.D., A. Radu, B.S., and A. W. Flake, M.D., Children’s Hospitalof Philadelphia, Philadelphia, PA
61. Delivery and Expression of Genes at 28 h Postfertiliza-tion in a Chick Model of Fetal Alcohol Syndrome. A.Thakur, M.D., J. B. Atkinson, M.D., and S. E. Fraser, Ph.D.,UCLA Medical Center and California Institute of Technology,Los Angeles, CA
4:00 pm–6:00 pm
Parallel Session IITRANSPLANT IEsplanade I–IIModerators: David A. Geller, M.D.
Dixon B. Kaufman, M.D.
62. Facilitating Cells Home to the Thymus after AllogeneicMarrow Transplantation. M. J. Schuchert, M.D., R. D.Wright, Y. L. Colson, M.D., Ph.D., University of Pittsburgh,Pittsburgh, PA, and Brigham and Women’s Hospital, Boston,MA
63. Cyclosporine Directly Promotes Epstein–Barr VirusTransformation of Human B Cells. J. C. Merrick, M.D., C.Chen, Ph.D., T. D. Johnston, M.D., K. S. Reddy, M.D., and D.Ranjan, M.D., University of Kentucky,, Lexington, KY
64. Protein Kinase C Inhibition Abrogates the ProtectiveEffect of Hepatic Ischemic Preconditioning. R. Ricciardi,M.D., R. S. Chari, M.D., R. D. Kim, M.D., B. K. Schaffer, M.D.,S. A. Shah, M.D., K. R. Sheth, M.D., M. P. Callery, M.D., S. H.Quarfordt, M.D., and W. C. Meyers, M.D., University of Mas-sachusetts Medical School, Worcester, MA
65. Protective Role of the L-Arginine–Nitric Oxide SynthasePathway on Preservation Injury after Rat Liver Trans-plantation. Y. Takahashi, M.D., S. H. Chia, M.D., G. P. Yag-nik, B.S., N. Murase, M.D., D. A. Geller, M.D., Starzl Trans-plant Institue, University of Pittsburgh, Pittsburgh, PA
66. The Effects of Bcl-2 Gene Transfer on the RegeneratingRat Liver. K. Taira, M.D., M. Shiraishi, Ph.D., S. Hiroyasu,M.D., M. Nagahama, M.D., E. Nozato, M.D., M. Toure, M.D., T.
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Ohshiro, M.D., and Y. Muto, M.D., University of the Ryukyus,Okinawa, Japan
67. Overexpression of Dominant-Negative (DN) IkBa Pro-
tects the MIN-6 Pancreatic b Cell Line from Cytokine-Induced Apoptosis. J. J. Wu, B.S., M. S. Baker, M.D.,J. Chen, M.D., Ph.D., and D. B. Kaufman, M.D., Ph.D., North-western University Medical School, Chicago, IL
68. 1,25-Dihydroxyvitamin D3 Alters the TGFb SignalingPathway in Renal Tissue. J. K. Aschenbrenner, M.D., G. J.Malin, B.S., H. W. Sollinger, M.D., Ph.D., B. N. Becker, M.D.,and D. A. Hullett, Ph.D., University of Wisconsin, Madison, WI
69. Solid Organ Transplantation of HIV Patients in the Eraof Highly Active Antiretroviral Therapy. S. Potdar, MD,S. F. Dodson, V. Scantlebury, R. Shapiro, J. J. Fung, and C. A.Bonham, University of Pittsburgh, Pittsburgh, PA
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Parallel Session IISHOCK IEsplanade IIIModerators: Ronald D. Robertson, M.D.
Steven E. Wolf, M.D.
70. The Actin-Binding Protein Gelsolin Ameliorates Pulmo-nary Edema Induced by Lysophosphatidic Acid. J. J.Schwartz, M.D., M. Sambade, M.D., H. Yin, Ph.D., and R. H.Turnage, M.D., Dallas VA Medical Center and University ofTexas Southwestern Medical School, Dallas, TX
71. TNF Receptor I Mediates Chemokine Production andNeutrophil Accumulation in the Lung Following Sys-temic LPS. C. M. Calkins, M.D., J. K. Heimbach, M.D., D. D.Bensard, M.D., X. Meng, Ph.D., and R. C. McIntyre, M.D.,University of Colorado Health Sciences Center, Denver, CO
72. NS398 Treatment after Trauma Attenuates Inflamma-tory Response and Increases Survival. V. E. Mack Strong,M.D., P. J. Mackrell, M.D., E. M. Concannon, B.S., J. R. Mestre,M.D., G. M. Symth, M.D., H. A. Naama, M.D., P. P. Stapleton,Ph.D., and J. M. Daly, M.D., Weill Medical College of CornellUniversity, New York, NY
73. Major Surgery Drives a Systemic ProinflammatoryT-Cell Response. K. J. Sweeney, AFRCSI, C. Coates, Bsc.,M. R. Kell, FRCS, and J. V. Reynolds, Mch., St. James’s Hos-pital, Dublin, Ireland
74. Pericytes Augment the Capillary Barrier Effect in inVitro Cocultures. C. J. Dente, M.D., C. P. Steffes, M.D., C.Speyer, Ph.D., and J. Tyburski, M.D., Wayne State University,Detroit, MI
75. Heparin Treatment of Endothelial Cells Decreases TheirLevels of Active Stress Kinases. M. Hamel, M.S., M. D.Cipolle, M.D., Ph.D., D. Kanyi, M.D., M. D. Pasquale, and L. J.Lowe-Krentz, Ph.D., Lehigh University, Bethlehem, PA, andLehigh Valley Hospital, Allentown, PA
76. Murine b-Defensin-3 Is an Inducible Peptide with Lim-ited Tissue Expression and Broad-Spectrum Antimicro-bial Activity. R. S. Burd, M.D., Ph.D., J. Sullivan, M.S., J. L.Furrer, B.S., and A. L. Smith, M.D., University of Missouri-Columbia Hospital, Columbia, MO
77. p38 MAPK: Posttranslational Regulation of TNF-a Ex-pression in Human PMN. B. W. Nolan, M.D., J. Friel, A. J.
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Duffy, M.D., K. Sheth, M.D., H. Collette, R.N., M. De, and P. E.Bankey, M.D., Ph.D., University of Massachusetts MedicalSchool, Worcester, MA
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ReceptionFlorida Aquarium
SATURDAY, NOVEMBER 4, 2000
7:00 am–8:00 am
Continental Breakfast/Poster ViewingGalleria B2-3
8:00 am–10:00 am
Parallel Session IIIEDUCATIONBuccaneer BModerators: Anne T. Mancino, M.D.
Lisa M. Colletti, M.D.
78. Assessment of Knowledge and Attitudes about Mela-noma Prevention among Teenagers. A. Lucci, M.D., and H.Citro, M.S., P.A.C., Baylor College of Medicine, Houston, TX
79. Patients’ Attitudes Regarding Involvement and Educa-tion of Surgical Residents. R. A. Cowles, M.D., C. A. Moyer,M.P.H., S. S. Sonnad, Ph.D., D. M. Simeone, MD, J. A. Knol,M.D., F. E. Eckhauser, M. W. Mulholland, M.D., Ph.D., andL. M. Colletti, M.D., University of Michigan, Ann Arbor, MI
80. Surgical Educator Preferences Regarding Clinical As-sessment Topics for Residents. G. J. Cerilli, M.D., H. W.Merrick, M.D., and E. D. Staren, M.D., Medical College of Ohio,Toledo, OH
81. Comparison of Performance 2 Years after the Old andNew (Interactive) ATLS Courses. J. Ali, M.D., R. Adam,M.B.Ch.B., I. Pierre, MBBS, H. Bedaysie, MBBS, D. Josa,MBBS, and J. Winn, R.N., University of West Indies and Uni-versity of Toronto, Toronto, Ontario, Canada
82. Factors Influencing Outcome on the American Board ofSurgery (ABS) Certifying Exam. E. Y. Sako, M.D., E.Petrusa, Ph.D., and J. Paukert, Ph.D., University of TexasHealth Science Center, San Antonio, TX, and Duke University,Durham, NC
83. A Model for Tracking Student Experiences on SurgicalClerkships. K. W. Millikan, M.D., and L. S. Hauge, Ph.D.,Rush Medical College, Chicago, IL
84. Future General Surgery Residents: Do Medical SchoolSurgical Rotations Influence Subspecialty Choice? H.Chen, M.D., J. M. Hardacre, M.D., C. Martin, and K. D. Lil-lemoe, M.D., Johns Hopkins Medical Institutions, Baltimore,MD
85. General Surgery Resident’s Postgraduate Year LevelDoes Not Influence Operating Room Time in Laparo-
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scopic Cholecystectomies. W. N. Wang, M.D., R. Marshal,M.D., and R. S. Haluck, M.D., The Milton S. Hershey MedicalCenter, Penn State, Hershey, PA
8:00 am–10:00 am
Parallel Session IIIPERIPHERAL VASCULAR IIBuccaneer C/DModerators: Vivian Gahtan, M.D.
Michael S. Conte, M.D.
86. Apoptosis in Human Vein Graft Stenosis. A. Westerband,M.D., D. C. James, M.D., C. L. Wixon, M.D., D. Crouse, B.S.,R. L. Heimark, Ph.D., J. D. Hughes, M.D., M. L. Aguirre, M.D.,W. T. Bellamy, Ph.D., and J. L. Mills, M.D., University ofArizona Health Sciences Center, Tucson, AZ
87. Proliferation of Human Vascular Smooth Muscle Cells(HVSMC) Is Regulated by Gender-Specific Protein Ki-nase C (PKC) a Expression. S. A. Miller, M.D., C. H. Selz-man, M.D., B. D. Shames, M.D., T. D. Morrell, M.D., F. G.Robertson, Ph.D., A. Banerjee, Ph.D., and A. H. Harken, M.D.,University of Colorado, Denver, CO
88. The Effect of Cotinine on Telomerase Activity in HumanVascular Smooth Muscle Cells. T. Jacob, Ph.D., E. Ascher,M.D., N. Clouden, M.D., A. P. Hingorani, M.D., Y. Gunduz,M.D., M. Ward, M.D., and B. Tsemekhim, M.D., MaimonidesMedical Center, Brooklyn, NY
89. Dacron Modification Alters Macrophage-Mediated Re-lease of Mitogens Active on Fibroblasts and Smooth Mus-cle Cells (SMC). T. M. Lam, M.D., C. W. Widenhouse, Ph.D.,N. Klingman, B.S., and J. M. Seeger, M.D., University of Flor-ida and the Malcom Randall VAMC, Gainesville, FL
90. Nicotine Induces Endothelial TNF-a Expression, WhichMediates Growth Retardation in Vitro. G. K. Albaugh,D.O., B. Kann, M.D., L. Strande, M.S., P. Vemulapalli, M.D.,and J. B. Alexander, M.D., UMDNJ–RWJMS/Cooper HealthSystem, Camden, NJ
91. Simvastatin Inhibits Mitogen-Induced Proliferation ofHuman Saphenous Vein Endothelial Cells throughS-Phase Reduction. R. B. Claytor, M.D., S. A. Shah, M.D.,M. P. Callery, M.D., J. M. Li, M.D., J. B. Herrmann, M.D., R. C.Harland, M.D., and M. J. Rohrer, M.D., University of Massa-chusetts Medical School, Worcester, MA
92. Effect of Diabetes on Acetylcholine Receptor Quantityand Function in Rat Endothelial Cells. F. Cannizzo, M.D.,Ph.D., R. B. Wait, M.D., Ph.D., C. Mueller, B.S., V. Nguyen,B.A., and L. S. Dresner, M.D., SUNY Downstate Medical Cen-ter, Brooklyn, NY, and Baystate Medical Center, Springfield,MA
93. Heterotypic Smooth Muscle Cell/Endothelial Cell Inter-actions Differ between Species. O. Imegwu, M.D., A. M.Graham, M.D., and G. B. Nackman, M.D., Robert Wood John-son Medical School, New Brunswick, NJ
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Parallel Session IIIGASTROINTESTINAL IIEsplanade I–IIModerators: William E. Fisher, M.D.
Sonia Y. Archer, M.D.
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94. Ileal Bile Acid Transport Protein Is Expressed in theJejunum Following Transplantation of Ileal MucosalStem Cells. M. G. Stelzner, M.D., V. D. Hoagland, B.S., and S.
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Somasundaram, Ph.D., Seattle VAMC/University of Washing-ton, Seattle, WA
95. Monochloramine Enhances the Basolateral Ca21-Dependent K1 Conductance in Human Intestinal Epithe-lial Cells. E. C. Mun, M.D., H. M. Kim, M.D., I. Calvo, M.D., J.Mayol, M.D., M. Prasad, M.D., and J. B. Matthews, M.D., BethIsrael Deaconess Medical Center/Harvard Medical School, Bos-ton, MA
96. Extrinsic Neural Innervation Modulates Absorption ofWater and Electrolytes in Canine Proximal Colon inVivo. M. L. Kendrick, M.D., T. Meile, C.M., N. J. Zyromski,M.D., T. Tanaka, M.D., J. A. Duenes, B.A., and M. G. Sarr,M.D., Mayo Clinic, Rochester, MN
97. Upregulation of Trail-Induced Apoptosis May Predis-pose to Pouchhitis. J. C. Coffey, M.B., M. W. Bennett, Ph.D.,J. H. Wang, Ph.D., P. Neary, J. O’Connell, F. Shanahan, MRCP,H. P. Redmond, FRCSI, and W. O. Kirwan, FRSCI, Cork Uni-versity Hospital, Cork, Ireland
98. Role of Mitochondrial Respiration during Calcium Sig-naling in Gastric Parietal Cells. S. A. Chamberlain, M.D.,A. M. Hofer, Ph.D., and D. I. Soybel, M.D., Brigham and Wom-en’s Hospital and the Boston VA Healthcare System, Bostonand West Roxbury, MA
99. p21 Gene Regulation during Enterocyte Differentiation:Identification of Activator and Repressor Elements. S. Y.Archer, M.D., J. J. Johnson, B.S., and R. A. Hodin, M.D., BethIsrael Deaconess Medical Center, Harvard Medical School, Bos-ton, MA
00. Integrin Expression Alters Internalization of EntericBacteria by Cultured Enterocytes. D. J. Hess, M.D., B.Feltis, M.D., J. Cromwell, M.D., J. Garcia-Aguilar, M.D., and C.Wells, Ph.D., University of Minnesota, Minneapolis, MN
01. Growth Regulation of Gut Epithelial Cells by TGF-b. Y.Cao, M.D., C. Xie, B.S., W. Yu, M.D., C. M. Townsend Jr., M.D.,E. A. Thompson, Ph.D., and T. C. Ko, M.D., University of TexasMedical Branch, Galveston, TX
8:00 am–10:00 am
Parallel Session IIIONCOLOGY IIEsplanade IIIModerators: Mike Kuang-Sing Chen, M.D.
Jeffrey A. Drebin, M.D.
102. Soluble Interleukin 6 Receptor (sIL-6R) Mediates Co-lonic Tumor Cell Adherence to the Vascular Endothe-lium: A Mechanism for Metastatic Initiation? J. F.Dowdall, FRCSI, D. C. Winter, M.D., E. Andrews, FRCSI, W. E.Laug, M.D., J. H. Wang, Ph.D., and H. P. Redmond, M.D., CorkUniversity Hospital, Cork, Ireland, and University of SouthernCalifornia, Los Angeles, CA
103. A Heat-Labile 10- to 100-kDa Gelatin-Binding Compo-nent of Serum Potentiates Pressure-Stimulated ColonCancer Cell Adhesion. S. M. Kavic, M.D., and M. D. Basson,M.D., Ph.D., Yale University and the CT VA Health CareSystem, New Haven, CT
104. FDG–PET Guided Surgery for Recurrent Colorectal
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Cancer: A Feasibility Study. E. E. Zervos, M.D., D. C. Desai,M.D., L. DePalatis, Ph.D., D. Soble, R.N., and E. W. Martin, Jr.,M.D., Ohio State University, Columbis, OH
105. Reverse Transcriptase-Polymerase Chain Reaction (RT-PCR) Analysis of Histologically Negative NonsentinelNodes in Melanoma. W. R. Wrightson, M.D., M. J. Edwards,M.D., J. Albrecht, Ph.D., A. J. Conrad, Ph.D., and K. M. Mc-Masters, M.D., Ph.D., University of Louisville, Louisville, KY,and National Genetics Institute, Los Angeles, CA
106. Cancer/Testis Antigen Expression May Correlate withStage of Progression in Melanoma. M. Patel, B.A., and J. S.Goydos, M.D., The Cancer Institute of New Jersey andUMDNJ–Robert Wood Johnson Medical Scool, New Brunswick,NJ
107. Prevention of the Growth and Metastasis of MalignantMelanoma: The Role of Supplemental Vitamin A. C. D.Tattini, M.D., S. Lynch, M.D., A. Spangenberger, B.S., R. Zie-nowicz, M.D., N. Weinzweig, M.D., L. Edstrom, M.D., and J.Weinzweig, M.D., Rhode Island Hospital/Brown University,Providence, RI
108. Microsatellite DNA Changes at Chromosome 4 in BenignBreast Epithelium from Risk-Defined Women. D. M. Eu-hus, M.D., N. Shivapurkar, M.D., S. Milchrub, M.D., G. N.Peters, M.D., A. M. Leitch, M.D., A. R. Richey, B.S., and A. F.Gazdar, M.D., University of Texas Southwestern Medical Cen-ter, Dallas, TX
109. Focal Adhesion Kinase (FAK) Is Increased in HumanProstate Cancer Specimens and Has Tissue-Specific Lo-calization. J. D. Rovin, M.D., H. F. Frierson, M.D., W. Ledinh,J. T. Parsons, Ph.D., and R. B. Adams, M.D., University ofVirginia, Charlottesville, VA
10:00 am–10:30am
Refreshments/Poster ViewingGalleria B2-3
10:30 am–11:15 am
Presidential AddressRegency Ballroom I–IV
“The Education of an Academic Surgeon”David I. Soybel, M.D.
1:15 am–12:00 am
Invited Guest SpeakerRegency Ballroom I–IV
“Academic Surgery Under Stress:Working toward a Solution”
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Laurence Y. Cheung, M.D.Professor and Chairman, Department of Surgery,
University of Kansas School of Medicine, Kansas City, Kansas
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12:00 am–1:00 pm
LuncheonRegency Ballroom V–VII
1:00 pm–3:00 pm
Parallel Session IVCARDIOTHORACIC/TRANSPLANT IIBuccaneer BModerators: John A. Goss, M.D.
Si Mai Pham, M.D.
110. Open-Heart Endocardial Radiofrequency Ablation as anAlternative to Incisions in Creating an Atrial Maze. J. A.Caccitolo, M.D., J. M. Stulak, M.S., D. Francischelli, D. N.Jensen, D.V.M., R. Mehra, Ph.D., and H. V. Schaff, M.D., MayoClinic, Rochester, MN, and Medtronic, Inc., Minneapolis, MN
11. Ventricular Dysfunction Following Reoxygenation ofHypoxic Myocardium Is Associated with PeroxynitriteFormation. J. M. Pearl, M.D., C. J. Wagner, B.S., D. P. Nelson,M.D., and J. Y. Duffy, Ph.D., Childrens’ Hospital Medical Cen-ter, Cincinnati, OH
12. Effects of Aging on Vascular Response to Injury: AgingMilieu versus Vessel Senescence. M. T. Calfa, M.D., A.Aitouche, Ph.D., C. Gay-Rabinstein, M.D., S. Li, M.D., and SiMai Pham, M.D., University of Miami School of Medicine, Mi-ami, FL
13. Rat Aortic Smooth Muscle Cell Density Affects Activa-tion of MAP Kinase and Akt by Menadione and PDGFHomodimer BB. X. A. Li, Ph.D., C. Bianchi, M.D., Ph.D., andF. W. Sellke, M.D., Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA
14. The Role of Chemokines in the Development of CMV-Accelerated Transplant Vascular Sclerosis. V. T. De LaMelena, M.D., C. N. Kreklywich, D. N. Streblow, Ph.D., Q. Yin,M.D., J. W. Cook, M.D., J. A. Nelson, Ph.D., and S. L. Orloff,M.D., Oregon Health Science University, Portland, OR
15. Influence of ex Vivo Graft Irradiation on Canine SmallBowel Transplantation. T. Ishikawa, M.D., K. Iwanami,M.D., T. Okuda, M.D., Y. Zhu, M.D., A. Fukuda, M.D., S.Zhang, B.S., J. Ou, M.D., M. Nalesnik, M.D., N. Murase, M.D.,and R. Venkataramanan, Ph.D., University of Pittsburgh,Pittsburgh, PA
16. In Vitro T Cell Proliferation from Human Kidney Trans-plant Biopsies with Unremarkable Pathology: NewStrategies for an Old Problem. C. R. Smith, M.D., N. J.Poindexter, Ph.D., N. S. Steward, K. C. Lu, M.D., D. C. Bren-nan, M.D., G. G. Singer, M.D., M. D. Jendrisak, M.D., S. She-noy, M.D., Ph.D., J. A. Lowell, M.D., T. K. Howard, M.D., andT. Mohanakumar, Ph.D., Washington University School ofMedicine, St. Louis, MO
117. Tacrolimus-Based Nonlethal Conditioning Leads to Sta-ble Mixed Chimerism and Donor-Specific Tolerance toLung Allografts in Rats. M. Thanikachalam, M.D., S. Li,A. D. Murdock, M.D., Y. Kurimoto, M.D., J. S. Gammie, M.D.,
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A. Zeevi, M.D., S. Yousem, M.D., and S. M. Pham, M.D., Uni-versity of Pittsburgh, Pittsburgh, PA, and University of Miami,Miami, FL
1:00 pm–3:00 pm
Parallel Session IVPERIPHERAL VASCULAR IIIBuccaneer C/DModerators: Robert A. Cambria, M.D.
Alex Westerband, M.D.
118. The Mitochondriopathy of Claudication Is Produced byPeripheral Arterial Disease (PAD) and Not AssociatedComorbidities. I. I. Pipinos, M.D., T. Denson, B.S., A. D.Shepard, M.D., P. V. Anagnostopoulos, M.D., A. Katsamouris,M.D., and M. D. Boska, Ph.D., Henry Ford Hospital, Detroit,MI
119. Inosine Attenuates Tourniquet-Induced Skeletal MuscleReperfusion Injury. A. Wakai, M.D., D. C. Winter, M.D., J. T.Street, M.B., R. G. O’Sullivan, M.B., J. H. Wagn, Ph.D., andH. P. Redmond, M.Ch., Cork University Hospital, Cork, Ireland
120. Chloroquine as an Inhibitor of 3-Aminopropanal-Induced Tissue Ischemia in the Rat Hindlimb. J. R. Syrek,M.D., S. Ivanova, Ph.D., S. Tabibzadeh, M.D., S. Friedman,M.D., L. Scher, M.D., and K. J. Tracey, M.D., North ShoreUniversity Hospital, Manhasset, NY
121. Exercise-Induced Hyperemia Unmasks Regional BloodFlow Deficit in Experimental Hindlimb Ischemia. L. S.Brevetti, M.D., R. Pack, M.D., S. M. Brady, B.A., J. I. Hoffman,M.D., R. Sarkar, M.D., Ph.D., and L. M. Messina, M.D., UCSF,San Francisco, CA
122. Growth Hormone Restores Ischemia–Reperfusion-Induced Diapragmatic Dysfunction. D. S. Moneley,AFRCSI, M. C. Barry, M.Ch., R. McLaughlin, M.Ch., C. Kelly,M.Ch., and D. J. Bouchier-Hayes, M.Ch., FRCS, Royal Collegeof Surgeons, Dublin, Ireland
123. Sustecal-Induced Postprandial Hyperemia Is Blockedby Adenosine A2b Receptor Antagonism in the Rat. P. J.Matheson, Ph.D., N. D. Carricato, B.S., P. D. Harris, Ph.D.,R. N. Garrison, M.D., and M. A. Wilson, M.D., Ph.D., Univer-sity of Louisville and Louisville VAMC, Louisville, KY
24. Examination of the Apoptotic Pathway and Proteolysisin the Pathogenesis of Popliteal Artery Aneurysms. T.Jacob, Ph.D., A. P. Hingorani, M.D., E. Ascher, M.D., Y. Gun-duz, M.D., and B. Tsemekhim, M.D., Maimonides Medical Cen-ter, Brooklyn, NY
25. Analysis of Coagulation Changes Associated with Su-praceliac (SC) Aortic Cross-clamping (AXC) UsingThromboelastography (TEG). P. V. Anagnostopoulos, M.D.,A. D. Shepard, M.D., I. I. Pipinos, M.D., P. A. Chaudhry, M.D.,S. B. K. Raman, M.D., T. Mishima, M.D., and H. Morita, M.D.,Henry Ford Hospital, Detroit, MI
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Parallel Session IVONCOLOGY IIIEsplanade I–IIModerators: David M. Euhus, M.D.
Gretchen M. Ahrendt, M.D.
26. Antitumor and Antiangiogenic Therapy with Somatosta-
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tin Receptor-Mediated in Situ Radiation. S. A. Gulec,M.D., G. J. Drouant, B.S., J. Fuselier, B.S., C. T. Anthony,Ph.D., J. B. Heneghan, Ph.D., J. B. Delcarpio, Ph.D., and E. A.
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Woltering, M.D., Louisiana State University Health SciencesCenter and Tulane University, New Orleans, LA
127. Blocking NF-kB Enhances Adriamycin Cytotoxicity.M. E. Murday, M.D., J. Malaty, M.S., S. Rekkas, B.S., P. Hebig,M.S., S. MacKay, Ph.D., L. L. Moldawer, Ph.D., S. Hochwald,M.D., E. M. Copeland, M.D., and D. S. Lind, M.D., University ofFlorida, Gainesville, FL
128. Antitumor Effect of Granulocyte Macrophage-ColonyStimulating Factor (GM-CSF) Expression by MurineHepatocellular Carcinoma Cells. A. L. O’Brien, M.D., X.Lin, Ph.D., J. A. Goss, M.D., F. C. Brunicardi, M.D., and P. Seu,M.D., Baylor College of Medicine and The Baylor/MethodistLiver Center, Houston, TX
129. Heat Shock Protein 70 Antisense Oligonucleotide Treat-ment Enhances 5-FU-Mediated Cancer Cell Death. F. Al-cocer, M.D., A. Gustin, M.D., J. Salazar, M.D., S. Vickers, M.D.,and W. D. Whitley, M.D., University of Alabama, Birmingham,AL
130. Exploitation of Tumor Hypoxia for Targeted CytokineExpression. N. Hanna, M.D., W. Al-Jumaily, Ph.D., M. Saun-ders, M.D., R. Salloum, M.D., H. Mauceri, Ph.D., and R Weich-selbaum, M.D., University of Kentucky Medical Center, Lex-ington, KY, University of Manchester, Manchester, UK, andUniversity of Chicago, Chicago, IL
131. Chemosensitization of Pancreatic Cancer by Inhibitionof the 26S Proteasome. R. J. Bold, M.D., S. Virudachalam,M.S., and D. J. McConkey, Ph.D., UC Davis Cancer Center,Sacramento, CA, and MD Anderson Cancer Center, Houston,TX
132. 26S Proteosome Inhibition Limits Growth of EstablishedPancreatic Cancer Xenografts. S. A. Shah, M.D., M. W.Potter, M.D., R. Ricciardi, M.D., and M. P. Callery, M.D.,FACS, University of Massachusetts Medical School, Worcester,MA
133. Human Ductal Pancreatic Adenocarcinoma (PDA) CellsThat Express PDX-1 Can Be Targeted with a Rat InsulinPromoter Thymidine Kinase Gene. T. A. Tirone, M.D., T.Lee, B.S., L. Nguyen, B.S., and F. C. Brunicardi, M.D., BaylorCollege of Medicine, Houston, TX
1:00 pm–3:00 pm
Parallel Session IVSHOCK II/GASTROINTESTINAL IIIEsplanade IIIModerators: Carlos Alvarez, M.D.
J. Perren Cobb, M.D.
134. Dehydroepiandrosterone (DHEA) Attenuates Hepatocel-lular Dysfunction and Liver Damage in Estrogen-Deficient Females Following Trauma-Hemorrhage. J. F.Kuebler, M.D., D. Jarrar, M.D., P. Wang, M.D., K. I. Bland,M.D., and I. H. Chaudry, Ph.D., University of Alabama atBirmingham, Birmingham, AL
135. Hypertonic Preconditioning Augments Hepatic HemeOxygenase-1 Following Ischemia–Reperfusion (I/R).G. D. Oreopoulos, M.D., J. Fan, Ph.D., S. B. Rizoli, M.D., Z. Lu,M.D., Y. H. Li, M.D., A. Kapus, Ph.D., and O. D. Rotstein, M.D.,
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University of Toronto, Toronto, Ontario, Canada
136. Comparison of ERK and JNK Activation Profiles inMouse Liver during Hemorrhagic Shock versus Hepatic
Ischemia. C. A. McCloskey, M.D., J. J. Baust, M.D., D. J.Gallo, and T. R. Billiar, M.D., University of Pittsburgh MedicalCenter, Pittsburgh, PA
137. FAK and AP-1 Activation Following Hypoosmotic Stressin HepG2 Cells Is Actin Cytoskeleton Dependent. R. D.Kim, M.D., C. E. Darling, M.D., T. P. Roth, M.S., R. Ricciardi,M.D., and R. S. Chari, M.D., University of Massachusetts Med-ical School, Worcester, MA
138. The Effects of Ischemia on Gene Expression. J. Huang,M.D., E. Dauway, M.D., R. Qi, Ph.D., J. Quackenbush, Ph.D., E.Lazaridis, Ph.D., and T. Yeatman, M.D., University of SouthFlorida, H Lee Moffitt Cancer Center, Tampa, FL, and TheInstitute for Genomic Research, Bethesda, MD
139. NF-kB Inhibition Enhances Peroxynitrite (ONOO2)-Induced Enterocyte Apoptosis. D. A. Potoka, M.D., E. P.Nadler, M.D., C. T. Wong, M.S., J. S. Upperman, M.D., andH. R. Ford, M.D., University of Pittsburgh and Childrens’ Hos-pital of Pittsburgh, Pittsburgh, PA
140. Inducible Nitric Oxide Synthase (NOS 2) Mediates Im-paired Small Intestinal Transit after Severe GutIschemia/Reperfusion (I/R). H. T. Hassoun, M.D., N. W.Weisbrodt, Ph.D., R. A. Kozar, M.D., Ph.D., D. W. Mercer, M.D.,F. G. Moody, M.D., and F. A. Moore, M.D., University of Texas/Houston Medical School, Houston, TX
141. The Effects of Bombesin on Gut Impairment after SevereBurn Injury. X. W. Wu, M.D., S. E. Wolf, M.D., M. Spies, M.D.,V. L. Chappell, M.D., D. N. Herndon, M.D., and J. C. Thomp-son, M.D., Shriners Burns Hospital/University of Texas Medi-cal Branch, Galveston, TX
3:00 pm–3:30 pm
Refreshment Break/View PostersGalleria B2-3
3:30 pm
Authors Remove Posters
3:30 pm–5:00 pm
Annual Business Meeting (Members Only)Regency Ballroom I–IV
6:30 pm–7:15 pm
Presidential ReceptionRegency Ballroom Foyer
7:15 pm–10:00 pm
Presidential BanquetRegency Ballroom V–VII
POSTER SESSION
P1. Relationship of Pulmonary Artery Elasticity and Imped-ance in Maturing Newborn Pigs. P. W. Domkowski, M.D.,Ph.D., R. H. Messier, Jr., M.D., Ph.D., L. H. Diadato, M.D., C.
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Jordan, B.S., and R. A. Hopkins, M.D., Brown UniversitySchool of Medicine, Provicence, RI, and Duke University Med-ical Center, Durham, NC
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P2. A New Surgical Adhesive (BioGlue) Causes AcutePhrenic Nerve Injury and Diaphragmatic Paralysis.S. A. LeMaire, M.D., Z. C. Schmittling, M.D., A. Undar, Ph.D.,J. S. Coselli, M.D., C. Koksoy, M.D., B. A. Deady, B.S., F. J.Clubb, D.V.M., Ph.D., C. D. Fraser, Jr., M.D., Baylor College ofMedicine and Texas Heart Institute, Houston, TX
P3. Effect of Creatine Monohydrate on Cardiac Function ina Rat Model of Endotoxemia. L. C. Vona-Davis, Ph.D., P. D.Wearden, M.D., Ph.D., N. K. Karne, B.S., and R. C. Hill, M.D.,West Virginia University, Morgantown, WV
P4. Advantages of Positron Emission Tomography overComputed Tomography in Mediastinal Staging of Non-Small Cell Lung Cancer. D. W von Haag, M.D., D. M..Follette, M.D., P. Roberts, M.D., L. Segel, Ph.D., and T. Taylor,R.N., University of California, Davis School of Medicine, Sac-ramento, CA
P5. Inotropic Support Improves Organ Blood Flow duringSimulated Off-Pump Bypass Surgery. J. A. Young, M.D., Y.Sun, M.D., L. W. Nifong, M.D., and W. R. Chitwood, Jr., M.D.,East Carolina University, Greenville, NC
P6. Fracture Locations Influence Likelihood of Rectal In-jury in Pelvic Fractures. R. Aihara, M.D., W. W. LaMorte,M.D.,Ph.D., M.P.H., E. F. Hirsch, M.D., and F. H. Millham,M.D., Boston University School of Medicine, Boston MedicalCenter, Boston, MA
P7. The Impact of a Clinical Pathway for Gastric BypassSurgery on Resource Utilization and Cost of Care. D. P.Bryant, M.D., R. Haluck, M.D., M. P. Rodgers, R.D., M. Low-ery, R.N., and R. N. Cooney, M.D., The Milton S. HersheyMedical Center, Hershey, PA
P8. Early and Late Outcome of Bedside Percutaneous Tra-cheostomy in the Intensive Care Unit. E. A. Mittendorf,M.D., C. R. McHenry, M.D., C. M. Smith, R.N., C. J. Yowler,M.D., and J. R. Peerless, M.D., MetroHealth Medical Center,Case Western Reserve University, Cleveland, OH
P9. Dedicated Craniofacial/Skull Base Trauma Team Im-proves Efficiency of Patient Care. R. A. Mathiasen, M.D.,R. Jarrahy, M.D., J. B. Eby, M.D, H. K. Shahinian, M.D., andD. R. Margulies, M.D., Cedars-Sinai Medical Center, Los An-geles, CA
10. The Chief Resident Roles as Surgeon, Teacher, Student,and Administrator on University and Public HospitalServices. D. J. Esposito, M.D., L. S. Hauge, Ph.D., H. Reyes,M.D., and R. A. Prinz, M.D., Cook County Hospital and RushUniversity, Chicago, IL
11. Managed Care Pilot Survey. D. S. Fusco, M.D., I. A. Mun-shi, M.D., L. Volz, M.D., D. W. Page, M.D., J. Garb, M.S., andR. B. Wait, M.D., Ph.D., Baystate Medical Center, Springfield,MA
12. Does Training of Specialty Residents Affect Patient Out-come in Vascular Surgery? T. T. Huynh, M.D., J. Abbas,M.D., H. J. Safi, M.D., and M. J. Reardon, M.D., Baylor Collegeof Medicine, The Methodist Hospital Houston, TX
13. Physician Leadership: A New Mandate in Surgical Edu-cation. K. M. F. Itani, M.D., K. Liscum, M.D., and F. C.
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Brunicardi, M.D., Baylor College of Medicine, Houston, TX
14. Evidence-Based Criteria for Teaching Surgical Resi-dents Endoscopy. M. J. Page, M.D., D. Carney, M.D., F. Y.
Lim, M.D., W. A. Koltun, M.D., and G. O. Maish, III, M.D.,Milton Hershey Medical Center, Pennsylvania State Univer-sity, Hershey, PA, and Lebanon VA Medical Center, Lebanon,PA
15. Statistical Methods in the Surgical Literature over thePast 15 Years. S. S. Sonnad, Ph.D., S. Dalal, M.P.H., andL. M. Colletti, M.D., University of Michigan, Ann Arbor, MI
16. Development of an Integrated Scoring System for Vir-tual Reality Skills Assessment. D. J. Scott, M.D., E. C.Hamilton, M.D., W. H. Frawley, Ph.D., S. T. Tesfay, R.N., andD. B. Jones, M.D., University of Texas Southwestern MedicalCenter, Dallas, TX
17. Circadian Rhythmicity in Intestinal Active Glucose Ab-sorption Is Anticipatory. A. Tavakkolizadeh, M.B., B.S.,FRCS, K. R. Shen, M.D., M. J. Zinner, M.D., S. W. Ashley,M.D., and E. E. Whang, M.D., Brigham and Women’s Hospital,Harvard Medical School, Boston, MA
18. Laparoscopic Repair of Traumatic Diaphragmatic Inju-ries. R. A. Kozar, M.D., Ph.D., L. J. Kaplan, M.D., J. Cipolla,M.D., J. Meija, M.D., and M. Haber, M.D., MCP-HahnemannSchool of Medicine, Philadelphia, PA, and University of Texas-Houston, Houston, TX
19. The Effect of Total Parenteral Nutrition (TPN) on CellCycle Regulator Expression in Rat Jejunum. C. M. Perez,M.D., E. Whang, M.D., J. Rounds, B.S., P. Abraham, B.S., N.Shimoda, M.D., K. Okamoto, M.D., and D. O. Jacobs, M.D.,M.P.H., Harvard Medical School, Brigham and Women’s Hos-pital, Boston, MA, and Creighton University, Omaha, NE
20. How Surgeon Age Affects Posttreatment SurveillanceStrategies for Melanoma Patients. J. A. Margenthaler,M.D., K. S. Virgo, Ph.D., D. Y. Johnson, B. S. Handler, M.D.,E. M. Sugarbaker, B.S., and F. E. Johnson, M.D., St. LouisUniversity Health Sciences Center and John Cochran Veter-ans Affairs Medical Center, St. Louis, MO
21. Innate Immune Response to Adenoviral Vector-Mediated Acute Pancreatitis. A. L. Shifrin, M.D., N. Chir-mule, Ph.D., K. Chapman, and S. E. Raper, M.D., University ofPennsylvania, Philadelphia, PA
22. Elastin Depletion in the Gastric Ligaments of Patientswith Hiatal Hernia. J. A. Curci, M.D., C. G. Davis, B.S., R. W.Thompson, M.D., and N. J. Soper, M.D., Washington Univer-sity School of Medicine, St. Louis, MO
23. Effects of Tezosentan, a Dual Endothelin Receptor An-tagonist, on the Cardiovascular and Renal Systems ofNeonatal Piglets. A. Chin, M.D., J. Radhakrishnan, M.D., L.Fornell, B.S., and E. John, M.D., University of Illinois at Chi-cago, Chicago, IL
24. A Novel Model for Studying Wound Healing. D. T. Efron,M.D., D. Most, M.D., H. P. Shi, M.D., and A. Barbul, M.D.,Sinai Hospital of Baltimore and the Johns Hopkins MedicalInstitutions, Baltimore, MD
25. A Reduction of TNF-a mRNA Expression in the BrainAttenuated Nitrogen Excretion in the Urine after Lapa-rotomy in Rats. T. Tajiri, M.D., S. Yoshida, M.D., N. Ishi-bashi, M.D., K. Tanaka, M.D., T. Muraoka, M.D., and K.
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Shirouzu, M.D., Kurume University School of Medicine, Ku-rume, Japan
P26. Significance of Ligand as a Prognostic Marker for Re-
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currence of Duke’s Stage B Colonic Carcinoma. S. Al-rawi, M.D., I. Alhamrawy, M.D., A. Shukur, M.D., J. Cunning-ham, M.D., A. J. Acinapura, M.D., and R. Raju, M.D., LutheranMedical Center and Maimonides Medical Center, Brooklyn,NY
27. Invasiveness and Regulation of MMP-2 and MMP-9 Ex-pression in Pancreatic Tumor Cell Line SUIT-2 and ItsSublines. X. Q. Yang, MSBS, J. E. Bartsch, MSBS, E. D.Staren, M.D., Ph.D., J. Howard, M.D., T. Iwamura, M.D.,Ph.D., and H. E. Appert, Ph.D., Medical College of Ohio, To-ledo, OH, and Miyazaki Medical College, Miyazaki, Japan
28. Regulation of MMP Expression in Breast Tumor CellLines. J. E. Bartsch, MSBS, X. Q. Yang, MSBS, E. D. Staren,M.D., Ph.D., and H. E. Appert, Ph.D., Medical College of Ohio,Toledo, OH
29. Doxycycline Inhibits Canine Osteosarcoma Cell Prolif-eration in Vitro by Inducing Cell Cycle Arrest in G1Phase and Apoptosis. A. M. Shoieb, Ph.D., J. L.. Bell, M.D.,and P. S. Dudrick, M.D., University of Tennessee GraduateSchool of Medicine, Knoxville, TN
P30. Sentinel Lymph Node Biopsy for Melanoma: Metastasesvs Benign Intracapsular Nevus in Sentinel Nodes. J. E.Duncan, M.D., D. Corbett, M.D., K. Hoffmeister, M.D., B.Knollmann-Ritschel, M.D., D. Turton, M.D., J. Williams, M.D.,and R. C. Jones, M.D., National Naval Medical Center, Be-thesda, MD
P31. Genistein Enhances Radiation Sensitivity of HumanMCF-7 Breast Cancer Cells in Vivo. J. L. Jones, M.D., J. R.Zhou, Ph.D., and G. L. Blackburn, M.D., Ph.D., Beth Israel-Deaconess Medical Center, Harvard Medical School, Boston,MA, and University of Tennessee Medical Center, Knoxville,TN
P32. Peptide YY Augments the Inhibitory Effects ofa-Tocopherol Succinate on Prostate Cancer CellGrowth. A. T. Rose, M.D., and D. W. McFadden, M.D., UCLAMedical Center, Los Angeles, CA
33. Thyroid Tumor Metastasis Is Associated with Hepara-nase Gene Expression. A. W. Kim, M.D., X. Xu, Ph.D., M.Olson, M.D., P. Gatusso, M.D., and R. A. Prinz, M.D., RushPresbyterian/St. Luke’s Medical Center, Chicago, IL
34. Predictors of Nonsentinel Lymph Node Metastasis inBreast Cancer Patients. U. Sachdev, M.D., K. Murphy, B.A.,A. Derzie, M.D., I. Bleiweiss, M.D., and S. Brower, M.D.,Mount Sinai Medical Center, New York, NY
35. Identification of Differential DNA Methylation inEsophageal Adenocarcinoma (EAC). S. K. Kurumboor,Ph.D., R. V. Lord, M.D., K. Wickramasinghe, M.D., and K. A.Skinner, M.D., University of Southern California, Los Angeles,CA
36. Inhibition of Constitutive RelA Activity Suppresses Ma-trix Metalloproteinase-9 (MMP-9) Production in HumanPancreatic Cancer. T. N. Wang, M.D., Ph.D., W. A. I. Fred-erick, M.D., T. Wu, D. B. Evans, M.D., and P. J. Chiao, Ph.D.,University of Texas M. D. Anderson Cancer Center, Houston,TX
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37. Inactivation of Rho in Lung Carcinoma Cell Lines Ex-pressing Mutant Ras Proteins Inhibits Proliferation andInduces Neurite Formation. K. A. Varker, M.D., J. S. Wise-
man, M.D., and C. L. Williams, Ph.D., Guthrie Research Insti-tute, Sayre, PA
38. v-Src Transformation Is Mediated in Part through Far-nesylated Proteins. S. C. Teng, M.D., J. Sun, Ph.D., R. Irby,Ph.D., S. Sebti, Ph.D., and T. J. Yeatman, M.D., H. Lee MoffittCancer Center, University of South Florida, Tampa, FL
39. A Molecular Hypothesis for the Phenomenon of Gener-alized Arteriomegaly and/or Peritoneal Inflammation inSome Patients with Abdominal Aortic Aneurysms. D.Syn, M.D., K. Hardy, B.A., S. Xia, M.D., and M. D. Tilson,M.D., Columbia University and St. Luke’s/Roosevelt Hospital,New York, NY
40. Homocysteine (Hcy) Promotes Chemotaxis and Acti-vates p38 in Bovine Aortic Smooth Muscle Cells (SMC).K. Akasaka, M.D., G. DiLuozzo, M.D., N. Akasaka, M.D., andB. E. Sumpio, M.D., Yale University School of Medicine, NewHaven, CT
41. Neointimal Hyperplasia in a Vein Graft Model. N. Angle,M.D., M. M. Farooq, M.D., C. Pross, M.D., H. Gelabert, M.D.,M. Fishbein, M.D., and J. A. Freischlag, M.D., UCLA Gonda(Goldschmied) Vascular Center, Los Angeles, CA
42. Cyclic Strain Induces RhoA Activation in Bovine AorticEndothelial Cells. A. H. Chen, M.D., S. Li, Ph.D., S. G.Frangos, M.D., G. DiLuozzo, M.D., A. Dhadwal, M.D., and B. E.Sumpio, M.D., Ph.D., Yale University School of Medicine, NewHaven, CT
43. Characterization of Gene Expression in Human SmoothMuscle Cells Following Thrombolysis. H. H. Dosluoglu,M.D., B. Radolinski, B.S., R. Saadeh, M.S., L. Harris, M.D.,and M. Dryjski, M.D., Ph.D., State University of New York atBuffalo, Buffalo, NY
44. External Beam Radiation Reduces Venous NeointimalHyperplasia in an Animal Model of PTFE DialysisGrafts. B. S. Kelly, M.D., S. C. Heffelfinger, M.D., A. Nara-yana, M.D., M. A. Miller, M.S., W. A. Karle, B.S., J. F. Whiting,M.D., J. W. Alexander, M.D., and P. Roy-Chaudhury, M.D.,University of Cincinnati Medical Center, Cincinnati, OH
45. Pravastatin Preserves Endothelial Vasomotor Functionin an Experimental Model of Diabetes Mellitus. D. S.Moneley, AFRCSI, C. Gang, M.D., E. Kay, FRCPath, C.Thompson, M.D., C. J. Kelly, M.Ch., and D. J. Bouchier-Hayes,M.Ch., Beaumont Hospital, Dublin, Ireland
46. IL-10 and Low Shear Stress-Induced Neointimal Hyper-plasia. J. E. Rectenwald, M.D., R. M. Minter, M.D., L. L.Moldawer, Ph.D., T. S. Huber, M.D., J. M. Seeger, M.D., andC. K. Ozaki, M.D., University of Florida College of Medicineand the Malcom Randall VAMC, Gainesville, FL
47. Early Vascular Lab Screening Can Increase the Numberof Arteriovenous Fistulae and Reduce the Need forCatheters to Initiate Dialysis. V. J. Teodorescu, M.D., K.Frasier, R.V.T., A. Falk, M.D., J. Uribarri, M.D., J. Vassalotti,M.D., M. A. DiNucci, R.N., and M. Kerstein, M.D., Mount SinaiMedical Center, New York, NY
48. Supplemental Oxygen Alters Arterial Wall Oxygen Con-
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centration after Stent Deployment. A. S. Tretinyak, M.D.,E. S. Lee, M.D., and S. M. Santilli, M.D., Ph.D., University ofMinnesota, Minneapolis, MN
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P49. Quality Control of Resident Experience: Compliancewith RRC Criteria. H. C. Veldenz, M.D., J. W. Dennis, M.D.,and P. S. Dovgan, M.D., University of Florida Health ScienceCenter, Jacksonville, FL
P50. Expression of MMP-1 (Active Form) and MMP-13 (La-tent Form) Varies by Location in Incompetant GreaterSaphenous Veins. D. L. Gillespie, M.D., A. Patel, B.S., B.Fileta, B.S., A. Flagg, B.S., S. Barnes, B.S., A. Chang, Ph.D., M.Kidwell, B.S., J. M. Goff, M.D., S. D. O’Donnell, M.D., J. L.Villaviccencio, M.D., and N. M. Rich, M.D., Uniformed ServicesUniversity, Bethesda, MD
P51. The Role of Pretransplant Recipient Dialysis in Early Re-nal Allograft Dysfunction. M. A. Beneke, M.D., G. A. Kaysen,M.D., Ph.D., J. P. McVicar, M.D., B. J. Gallay, M.D., and R. V.Perez, M.D., UC Davis Medical Center, Sacramento, CA
52. Regression of Early- and Late-Stage Mammary Tumorsafter Adoptive Transfer of Bryostatin- and Ionomycin-Activated Lymphocytes Is Mediated By CD81 T-CellsNecessary for Effect. C. S. Chin, M.D., L. Graham, G. G.Hamad, M.D., K. R. Creasy, and H. D. Bear, M.D., MedicalCollege of Virginia at Virginia Commonwealth University,Richmond, VA
53. Neointimal Hyperplasia Following Carotid Artery Bal-loon Angioplasty Is Accelerated by Hyperhomo-cyst(E)inemia. J. W. Cook, M.D., M. R. Malinow, M.D., andS. L. Orloff, M.D., Oregon Health Sciences University andOregon Regional Primate Research Center, Portland, OR
54. Organ Transplant Specificity of Tolerance with Nonde-pleting Anti-CD4 Monoclonal Antibody RIB 5/2 and In-travenous Donor Alloantigen. N. Otomo, M.D., Y. Shimizu,M.D., J. Margenthaler, M.D., S. Yu, M.S., M. Lehmann, M.D.,Ph.D., and M. W. Flye, M.D., Ph.D., Washington UniversitySchool of Medicine, St. Louis, MO
55. Genistein Delays Rejection of Rat Cardiac AllograftsTreated with or without Cyclosporine. A. J. Gruneiro,M.D., I. B. Cetindag, M.D., A. D. Weberg, M.S., and T. P.O’Connor, M.D., SIU School of Medicine, Springfield, IL
56. High-Lipid Diets Alter in Vivo and in Vitro ImmuneReactivity and Lymphocyte Membrane Lipids. R. A.Iglesias-Marquez, M.D., E. Santiago-Delpin, M.D., A. A.Roman-Franco, C. Estrada, and D. Roman, University ofPuerto Rico and VA Hospital, San Juan, Puerto Rico
57. Cold Ischemic Injury Accelerates Allograft Vasculopathyvia Enhanced Proinflammatory Cytokine Expression. E.Reiss, M.D., E. Fishman, M.D., H. Liu, M.D., Ph.D., and R.Knight, M.D., Mount Sinai Medical Center, New York, NY
58. Mechanisms of Tolerance Induction in the Heart/KidneyModel in Miniature Swine. J. D. Mezrich, M.D., K. Mawu-lawde, M.D., K. Yamada, M.D., R. S. Lee, M.D., M. L. Schwarze,M.D., M. E. Maloney, B.A., E. P. Pillsbury, B.A., S. L. Houser,M.D., D. H. Sachs, M.D., and J. C. Madsen, M.D., MassachusettsGeneral Hospital and Harvard Medical School, Boston, MA
59. Hepatic Sinusoidal Endothelium, Compared to AorticEndothelium, Exhibits a Unique Pattern of IL-1a,TNF-a, and IFN-g Upregulation in Response to Xenoge-neic Islets in an in Vitro Dog-to-Pig Model of Discordant
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Islet Xenotransplant. M. Tan, M.D., A. DiCarlo, M.D., J. I.Tchervenkov, M.D., and P. Metrakos, M.D., McGill UniversityHealth Centre, Montreal, Quebec, Canada
P60. Increased Expression Connective Tissue Growth Factor(CTGF) in Posttransplant Obliterative Arteriopathy. M.Thanikachalam, M.D., J. Fukada, M.D., M. Calfa, M.D., M.Perez, M.D., G. R. Grotendorst, Ph.D., and S. M. Pham, M.D.,University of Miami, Miami, FL
P61. Human Anti-Porcine Xenogeneic Responses: Releaseof Human Th1 Cytokines and Induction of PorcineEndothelial Surface Molecules. T. S. Coleman, B.S.,H. K. Pittman, B.S., S. M. Purser, MAED, C. E. Haisch,M.D., and K. M. Verbanac, Ph.D., East Carolina University,Greenville, NC
P62. High Lung Inflation Pressures Restrict Acellular Hemo-globin Entry into Alveolar Septa Less Than Red CellEntry. M. J. Schurr, M.D., R. Conhaim, Ph.D., L. Rodenkirch,B.S., K. Watson, B.S., and B. Harms, M.D., University of Wis-consin Hospital, Madison, WI
P63. Elevated Serum Sulfite Concentration in Septic Pa-tients. K. Koike, M.D., H. Kajiyama, M.D., H. Mitsuhashi,M.D., Y. Nojima, M.D., T. Mochizuki, M.D., T. Masuno,M.D., N. Sato, M.D., S. Kushimoto, M.D., Y. Koido, M.D., M.Kawai, M.D., and Y. Yamamoto, M.D., Nippon MedicalSchool, Tokyo, Japan andGunma University of Medicine,Gunma, Japan
P64. Demonstration of Hsp 70 and Hsp 60 in BioengineeredLiving Skin Equivalents Undergoing Thermal Injury. P.Vemulapalli, M.D., J. L. VanTran, B. Kann, M.D., G. Albuagh,D.O., L. Strande, E. Doolin, M.D., and C. W. Hewitt, Ph.D.,UMDNJ–RWJMS, Cooper Hospital, Camden, NJ
P65. Low-Volume Resuscitation Exacerbates Hepatic Vascu-lar Stress Gene-Dependent Microvascular Dysfunctionin Sepsis. R. Baveja, M.D., N. Kresge, B.A., Y. Yokoyama,M.D., N. Sonin, Ph.D., J. X. Zhang, Ph.D., M. G. Clemens,Ph.D., and T. Huynh, M.D., Carolinas Medical Center andBiology, University of North Carolina, Charlotte, NC
P66. Bacterial Wall Components Enhance Tumor Cell Meta-static Potential. M. Doyle, J. H. Wang, and H. P. Redmond,M.Ch., University College Cork, Cork, Ireland
P67. Paradoxical in Vitro and in Vivo Effects of Clostridiumdifficile Toxins. B. A. Feltis, M.D., D. Sahar, M.D., and C. L.Wells, Ph.D., University of Minnesota, Minneapolis, MN
P68. Induction of TNF-a Expression and Apoptosis in the Thy-mus of Mice after Burn Injury. K. Cho, Ph.D., L. K. Adamson,B.S., and D. G. Greenhalgh, M.D., Shriners Hospitals for Chil-dren, University of California at Davis, Sacramento, CA
69. Effects of Methylene Blue (MB) on Tissue Perfusion dur-ing Septic Shock in Dogs. V. B. Kim, M.D., R. J. Albrecht,M.D., L. W. Nifong, M.D., Y. S. Sun, M.D., and W. R. Chitwood,Jr., M.D., Brody School of Medicine at East Carolina Univer-sity, Greenville, NC
70. Endotoxin Antagonists of Different Classes Alter Mac-rophage Uptake of Lipopolysaccharide in DisparateManners. V. Lazaron, M.D., Ph.D., K. Wasiluk, Ph.D., T.Kellogg, M.D., and D. L. Dunn, M.D., Ph.D., University ofMinnesota, Minneapolis, MN
71. Multiple Trauma Is Proangiogenic. R. G. O’Sullivan, M.B.,
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J. T. Street, M.B., A. Wakai, M.B., J. H. Wang, Ph.D., and H. P.Redmond, M.Ch., Cork University Hospital, Wilton, Cork, Ire-land
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P72. Bacterial Wall Products Attenuate VEGF-Mediated An-giogenesis: A Putative Mechanism for Delayed WoundHealing in Sepsis? C. Power, M.D., J. Wang, Ph.D., J. Street,M.D., and H. P. Redmond, M.Ch., Cork University Hospital,Cork, Ireland
P73. The Actin Cytoskeleton: Opposing Roles in Adherentand Nonadherent Monocytes. M. R. Rosengart, M.D., S.Arbabi, M.D., I. Garcia, B.A., R. Winn, Ph.D., and R. Maier,M.D., University of Washington, Seattle, WA
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P74. Heat Shock Protein 27 Inhibits Apoptosis in HumanNeutrophils. K. Sheth, M.D., A. Duffy, M.D., A. De,
Ph.D., R. Ricciardi, M.D., B. Nolan, M.D., and P. E. Bankey,M.D., University of Massachusetts Medical School, Worces-ter, MA
P75. Caspase-3, Caspase-9, and Mitochondria Mediate NitricOxide-Induced Dendritic Cell Apoptosis. A. Stanford,M.D., Y. Chen, Ph.D., X. Zhou, Ph.D., X. Zhang, and H. R. Ford,M.D., University of Pitsburgh, Pittsburgh, PA
P76. Caspase-3 Inhibition Partially Restores Oxidant Pro-duction in Apoptotic Human Neutrophils (PMN). J. F.Sweeney, M.D., P. K. Nguyen, M.S., and D. B. Hinshaw, M.D.,
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University of Michigan and Surgery Service, Ann Arbor,VAMC, Ann Arbor, MI