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Discovering New Drug-Drug InteractionsBy Text-Mining the Biomedical Literature
Beth PerchaCS 224NFinal ProjectMarch 17, 2011
Background
●Americans are on a lot of drugs.
●Drug interactions are bad.
●We don't test for them in clinical trials.
●We need ways to find likely interactions so we can watch out for them.
Methods (I)
Start with indexed version of Medline:17 million abstracts88 million sentences
Two lexicons:Genes (43 VIP genes)Drugs (602; at least one interaction)
AND
Methods (II)
Results (I)
Results (II)
Most likely interactions... Least likely interactions...
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