central nervous system control of triglyceride metabolism-04
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8/9/2019 Central Nervous System Control of Triglyceride Metabolism-04
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Cover Page
The handle http://hdl.handle.net/1887/22040 holds various files of this Leiden Universitydissertation.
Author : Geerling, Janine JanettaTitle : Central nervous system control of triglyceride metabolismIssue Date : 2013-10-23
http://hdl.handle.net/1887/22040http://hdl.handle.net/1887/22040http://hdl.handle.net/1887/22040https://openaccess.leidenuniv.nl/handle/1887/1http://hdl.handle.net/1887/22040https://openaccess.leidenuniv.nl/handle/1887/1
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GLP-1 RECEPTOR ACTIVATION INHIBITSVLDL PRODUCTION AND REVERSES
HEPATIC STEATOSIS BY DECREASINGHEPATIC LIPOGENESIS IN HIGH-FAT-FED
APOE*3-LEIDEN MICE
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GLP-1 RECEPTOR AGONISM REDUCES VLDL PRODUCTION
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ABSTRACT
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GLP-1 RECEPTOR AGONISM REDUCES VLDL PRODUCTION
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MATERIALS AND METHODS
Animals
Experiments
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CHAPTER 4
Compounds
Plasma glucose and insulin analysis
Hepatic VLDL-TG and VLDL-apoB production
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GLP-1 RECEPTOR AGONISM REDUCES VLDL PRODUCTION
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Hepatic lipid content
Hepatic gene expression analysis
Statistical analysis
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CHAPTER 4
RESULTS
GLP-1 receptor agonism reduces body weight and fasting plasma glucose andinsulin levels in high fat diet-fed E3L mice
GLP-1 receptor agonism reduces hepatic secretion of VLDL particles withoutaffecting particle composition
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GLP-1 RECEPTOR AGONISM REDUCES VLDL PRODUCTION
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GLP-1 receptor agonism reverses high fat diet-induced hepatic steatosis
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CHAPTER 4
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CHAPTER 4
GLP-1 receptor agonism affects muscle expression of genes involved in fatty acidoxidation
DISCUSSION
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GLP-1 RECEPTOR AGONISM REDUCES VLDL PRODUCTION
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GLP-1 RECEPTOR AGONISM REDUCES VLDL PRODUCTION
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CHAPTER 4
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GLP-1 RECEPTOR AGONISM REDUCES VLDL PRODUCTION
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REFERENCES
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CHAPTER 4
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GLP-1 RECEPTOR AGONISM REDUCES VLDL PRODUCTION
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