antibodymhc rearranging muppets mhc part ii 200 400 600 800 1000 200 400 600 800 1000 200 400 600...

Antibody MHC Rearranging Muppets MHC Part II

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A 200

• Answer: This antibody isotype is found as a dimer in its secreted form

• Question: What is IgA?

A 400

• Answer: These are the two types of immunoglobulin light chains.

• Question: What are kappa and lambda?

A 600

• Answer: This protease cleaves antibody molecules into 2 Fab fragments and 1 Fc fragment.

• Question: What is papain?

A 800

• Answer: The average kappa:lamda in humans is?

• Question: What is 2:1?

A 1000

• Answer: This is the most variable hypervariable region in antibody.

• Question: What is HV3 (or CDR3)?

B 200

• Answer: This is the type of MHC that presents to CD4+ Th cells

• Question: What is MHC type II?

B 400

• Answer: These two chains together form MHC type I.

• Question: What is an alpha chain and beta-2 microglobulin?

B 600

• Answer: CD8 binds to this invariant site on MHC molecules.

• Question: What is the alpha3 domain?

B 800

• Answer: Peptides that bind to MHC class I molecules are usually this many amino acids long.

• Question: What is 8-10?

B 1000

• Answer: A stable MHC type II found on a cell surface, necessarily has these components.

• Question: What are an alpha chain, a beta chain, and peptide?

C 200

• Answer: In Ig heavy chain rearrangement, these segments are the first to rearrange.

• Question: What are D and J?

C 400

• Answer: In TCR alpha chain rearrangement, these segments are the first to rearrange.

• Question: What are V and J?

C 600

• Answer: This molecule cleaves an excision circle out of DNA and closes hairpins at the ends of the remaining DNA.

• Question: What is RAG?

C 800

• Answer: The recombination signal sequence is made of these 3 components

• Question: What are a heptamer, a spacer, and a nonamer?

C 1000

• Answer: These two enzymes aid B cells in class switching and when defective result in a type of hyper-IgM syndrome

• Question: What are AID and UNG?

D 200

• Answer: This creator of the Muppets died of strep septicemia at the age of 53.

• Question: Who is Jim Henson?

D 400

• Question: Since 2004, this company has owned the The Muppets franchise.

• Answer: What is Disney?

D 600

• Answer: This song performed by Kermit the Frog from The Muppet Movie reached number 25 on the Billboard charts in 1979.

• Question: What is Rainbow Connection?

D 800

• Answer: He is the voice of both Miss Piggy and Yoda.

• Question: Who is Frank Oz?

D 1000

• Answer: Although no celebrity has appeared on The Muppet Show twice, this guest start appeared on The Muppet Show and two special Muppet holiday programs.

• Question: Who is John Denver?

E 200

• Answer: In class I MHC creation, peptides are assisted from the cytosol to the ER by this molecule.

• Question: What is TAP?

E 400

• Answer: In the ER, peptide is prevented from loading onto the cleft of MHC class II by this.

• Question: What is the invariant chain?

E 600

• Answer: This molecule catalyzes the release of the CLIP from the MHC class II

• Question: What is HLA-DM?

E 800

• Answer: The MHC is located on this chromosome in humans.

• Question: What is chromosome 6?

E 1000

• Answer: This molecule forms a bridge from where peptide enters the ER to the MHC class I molecule.

• Answer: What is tapasin?