antibodymhc rearranging muppets mhc part ii 200 400 600 800 1000 200 400 600 800 1000 200 400 600...

26
Antibody MHC Rearranging Muppets MHC Part II 200 400 600 800 100 0 200 400 600 800 100 0 200 400 600 800 100 0 200 400 600 800 100 0 200 400 600 800 100 0

Upload: lorraine-norris

Post on 22-Dec-2015

223 views

Category:

Documents


0 download

TRANSCRIPT

Page 1: AntibodyMHC Rearranging Muppets MHC Part II 200 400 600 800 1000 200 400 600 800 1000 200 400 600 800 1000 200 400 600 800 1000 200 400 600 800 1000

Antibody MHC Rearranging Muppets MHC Part II

200

400

600

800

1000

200

400

600

800

1000

200

400

600

800

1000

200

400

600

800

1000

200

400

600

800

1000

Page 2: AntibodyMHC Rearranging Muppets MHC Part II 200 400 600 800 1000 200 400 600 800 1000 200 400 600 800 1000 200 400 600 800 1000 200 400 600 800 1000

A 200

• Answer: This antibody isotype is found as a dimer in its secreted form

• Question: What is IgA?

Page 3: AntibodyMHC Rearranging Muppets MHC Part II 200 400 600 800 1000 200 400 600 800 1000 200 400 600 800 1000 200 400 600 800 1000 200 400 600 800 1000

A 400

• Answer: These are the two types of immunoglobulin light chains.

• Question: What are kappa and lambda?

Page 4: AntibodyMHC Rearranging Muppets MHC Part II 200 400 600 800 1000 200 400 600 800 1000 200 400 600 800 1000 200 400 600 800 1000 200 400 600 800 1000

A 600

• Answer: This protease cleaves antibody molecules into 2 Fab fragments and 1 Fc fragment.

• Question: What is papain?

Page 5: AntibodyMHC Rearranging Muppets MHC Part II 200 400 600 800 1000 200 400 600 800 1000 200 400 600 800 1000 200 400 600 800 1000 200 400 600 800 1000

A 800

• Answer: The average kappa:lamda in humans is?

• Question: What is 2:1?

Page 6: AntibodyMHC Rearranging Muppets MHC Part II 200 400 600 800 1000 200 400 600 800 1000 200 400 600 800 1000 200 400 600 800 1000 200 400 600 800 1000

A 1000

• Answer: This is the most variable hypervariable region in antibody.

• Question: What is HV3 (or CDR3)?

Page 7: AntibodyMHC Rearranging Muppets MHC Part II 200 400 600 800 1000 200 400 600 800 1000 200 400 600 800 1000 200 400 600 800 1000 200 400 600 800 1000

B 200

• Answer: This is the type of MHC that presents to CD4+ Th cells

• Question: What is MHC type II?

Page 8: AntibodyMHC Rearranging Muppets MHC Part II 200 400 600 800 1000 200 400 600 800 1000 200 400 600 800 1000 200 400 600 800 1000 200 400 600 800 1000

B 400

• Answer: These two chains together form MHC type I.

• Question: What is an alpha chain and beta-2 microglobulin?

Page 9: AntibodyMHC Rearranging Muppets MHC Part II 200 400 600 800 1000 200 400 600 800 1000 200 400 600 800 1000 200 400 600 800 1000 200 400 600 800 1000

B 600

• Answer: CD8 binds to this invariant site on MHC molecules.

• Question: What is the alpha3 domain?

Page 10: AntibodyMHC Rearranging Muppets MHC Part II 200 400 600 800 1000 200 400 600 800 1000 200 400 600 800 1000 200 400 600 800 1000 200 400 600 800 1000

B 800

• Answer: Peptides that bind to MHC class I molecules are usually this many amino acids long.

• Question: What is 8-10?

Page 11: AntibodyMHC Rearranging Muppets MHC Part II 200 400 600 800 1000 200 400 600 800 1000 200 400 600 800 1000 200 400 600 800 1000 200 400 600 800 1000

B 1000

• Answer: A stable MHC type II found on a cell surface, necessarily has these components.

• Question: What are an alpha chain, a beta chain, and peptide?

Page 12: AntibodyMHC Rearranging Muppets MHC Part II 200 400 600 800 1000 200 400 600 800 1000 200 400 600 800 1000 200 400 600 800 1000 200 400 600 800 1000

C 200

• Answer: In Ig heavy chain rearrangement, these segments are the first to rearrange.

• Question: What are D and J?

Page 13: AntibodyMHC Rearranging Muppets MHC Part II 200 400 600 800 1000 200 400 600 800 1000 200 400 600 800 1000 200 400 600 800 1000 200 400 600 800 1000

C 400

• Answer: In TCR alpha chain rearrangement, these segments are the first to rearrange.

• Question: What are V and J?

Page 14: AntibodyMHC Rearranging Muppets MHC Part II 200 400 600 800 1000 200 400 600 800 1000 200 400 600 800 1000 200 400 600 800 1000 200 400 600 800 1000

C 600

• Answer: This molecule cleaves an excision circle out of DNA and closes hairpins at the ends of the remaining DNA.

• Question: What is RAG?

Page 15: AntibodyMHC Rearranging Muppets MHC Part II 200 400 600 800 1000 200 400 600 800 1000 200 400 600 800 1000 200 400 600 800 1000 200 400 600 800 1000

C 800

• Answer: The recombination signal sequence is made of these 3 components

• Question: What are a heptamer, a spacer, and a nonamer?

Page 16: AntibodyMHC Rearranging Muppets MHC Part II 200 400 600 800 1000 200 400 600 800 1000 200 400 600 800 1000 200 400 600 800 1000 200 400 600 800 1000

C 1000

• Answer: These two enzymes aid B cells in class switching and when defective result in a type of hyper-IgM syndrome

• Question: What are AID and UNG?

Page 17: AntibodyMHC Rearranging Muppets MHC Part II 200 400 600 800 1000 200 400 600 800 1000 200 400 600 800 1000 200 400 600 800 1000 200 400 600 800 1000

D 200

• Answer: This creator of the Muppets died of strep septicemia at the age of 53.

• Question: Who is Jim Henson?

Page 18: AntibodyMHC Rearranging Muppets MHC Part II 200 400 600 800 1000 200 400 600 800 1000 200 400 600 800 1000 200 400 600 800 1000 200 400 600 800 1000

D 400

• Question: Since 2004, this company has owned the The Muppets franchise.

• Answer: What is Disney?

Page 19: AntibodyMHC Rearranging Muppets MHC Part II 200 400 600 800 1000 200 400 600 800 1000 200 400 600 800 1000 200 400 600 800 1000 200 400 600 800 1000

D 600

• Answer: This song performed by Kermit the Frog from The Muppet Movie reached number 25 on the Billboard charts in 1979.

• Question: What is Rainbow Connection?

Page 20: AntibodyMHC Rearranging Muppets MHC Part II 200 400 600 800 1000 200 400 600 800 1000 200 400 600 800 1000 200 400 600 800 1000 200 400 600 800 1000

D 800

• Answer: He is the voice of both Miss Piggy and Yoda.

• Question: Who is Frank Oz?

Page 21: AntibodyMHC Rearranging Muppets MHC Part II 200 400 600 800 1000 200 400 600 800 1000 200 400 600 800 1000 200 400 600 800 1000 200 400 600 800 1000

D 1000

• Answer: Although no celebrity has appeared on The Muppet Show twice, this guest start appeared on The Muppet Show and two special Muppet holiday programs.

• Question: Who is John Denver?

Page 22: AntibodyMHC Rearranging Muppets MHC Part II 200 400 600 800 1000 200 400 600 800 1000 200 400 600 800 1000 200 400 600 800 1000 200 400 600 800 1000

E 200

• Answer: In class I MHC creation, peptides are assisted from the cytosol to the ER by this molecule.

• Question: What is TAP?

Page 23: AntibodyMHC Rearranging Muppets MHC Part II 200 400 600 800 1000 200 400 600 800 1000 200 400 600 800 1000 200 400 600 800 1000 200 400 600 800 1000

E 400

• Answer: In the ER, peptide is prevented from loading onto the cleft of MHC class II by this.

• Question: What is the invariant chain?

Page 24: AntibodyMHC Rearranging Muppets MHC Part II 200 400 600 800 1000 200 400 600 800 1000 200 400 600 800 1000 200 400 600 800 1000 200 400 600 800 1000

E 600

• Answer: This molecule catalyzes the release of the CLIP from the MHC class II

• Question: What is HLA-DM?

Page 25: AntibodyMHC Rearranging Muppets MHC Part II 200 400 600 800 1000 200 400 600 800 1000 200 400 600 800 1000 200 400 600 800 1000 200 400 600 800 1000

E 800

• Answer: The MHC is located on this chromosome in humans.

• Question: What is chromosome 6?

Page 26: AntibodyMHC Rearranging Muppets MHC Part II 200 400 600 800 1000 200 400 600 800 1000 200 400 600 800 1000 200 400 600 800 1000 200 400 600 800 1000

E 1000

• Answer: This molecule forms a bridge from where peptide enters the ER to the MHC class I molecule.

• Answer: What is tapasin?