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ProphylaxisProphylaxis

Healthy animals treated.No BRD outbreak in the herd...

ProphylaxisProphylaxis

Herd management!Vaccinations!Antibiotics?

WhyWhy BRD & BRD & antibiopreventionantibioprevention in in the real life?the real life?

Fattening

Breeding herd

Vealcalves

FatteningFattening

France, Assie 2009 1167 young beef animals

1083 brought in 84 born at fattening site

71 herds 18,1% morbidity

1,2% for those born at fattening site 19,4% for those bought outside

FatteningFattening

Losses analysis Mortality (67%) Treatment costs

(16%) Management costs

(14%)

Losses analysis

0

0,1

0,2

0,3

0,4

0,5

0,6

0,7

0,8

0,9

1

Mortality Treatmentcosts

Managementcosts

Breeder Breeder herdherd

France, Assie 2009 7496 non-weaned calves 156 herds

17% morbidity

Income impact From -2% to -20%

Breeder Breeder herdherd

Treatment costs are always minor, regarding zootechnicallosses

Prevention management & income impact...Losses analysis and income impact of BRD, depending on the

incidence

0%

10%

20%

30%

40%

50%

60%

70%

80%

90%

100%

Low incidence(22% of herds)

Mild incidence(17% of herds)

High incidence(28% of herds)

Severe cases(12% of herds)

Zootechnical losses

Treatment andmanpower

Income impact

VealVeal calvescalves

3 years survey 42000 veal calves 78 herds

Prim’Holstein vealsBucket AMF All

Respiratory DiseasesNb of collective treatments

Veals individually treated %

Relapse

Other breed vealsBucket AMF All

Respiratory Diseases

Nb of collective treatments

Veals individually treated %

Relapse

WhateverWhatever the the breedingbreeding system system isis, , preventionprevention isis fundamentalfundamental

Herd management Vaccinations Antibiotics?

Only in very specific situations Veterinary prescription

ZACTRAN is the « tool » to avoidantibioprevention

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MetaphylaxisMetaphylaxis

« Healthy » animals treatedbecause of BRD outbreak on other

animals close to them

UsualUsual metaphylaxismetaphylaxis strategystrategy

Curative treatment on sick animals+

Metaphylactic treatment on at-risk animals

TargetedTargeted metaphylaxismetaphylaxis

Curative treatment on sick animals+

Metaphylactic treatment on a part of at-risk animals

Thanks to extraordinary PK/PD parameters of ZACTRAN

Focus on...Focus on...

Extraordinary PK/PD parameters

Gamithromycin concentration in broncho-alveolar cells

0

2

4

6

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14

16

18

20

0

1 da

y

2 da

ys

3 da

ys

4 da

ys

5 da

ys

6 da

ys

7 da

ys

8 da

ys

9 da

ys

10 d

ays

11 d

ays

12 d

ays

13 d

ays

14 d

ays

15 d

ays

Time after injection

µg/ml

MIC90 Mannheimia haemolytica MIC90 Pasteurella multocida & Histophilus somni

FastFast, , hugehuge concentration*, long concentration*, long lasting in the lasting in the heartheart of the of the lunglung

Fast acting< 30 minutes after one subcutaneous shot

Huge concentration18 to 36 times the MIC90

Long lasting

TargetedTargeted metaphylaxismetaphylaxis

Deux-Chaises (Allier) March-July 09 Aim

o Assess the efficacy of ZACTRAN in metaphylactic and curative treatments, in natural conditions

Field Field studystudy descriptiondescription

167 cattle from 8 different sources Males and females 4.5 months to 11 months of age 188 to 420 kg Limousin and Charolais

A confortable A confortable housinghousing

16 pens, 8 on each side of the aisle Bedded on straw (deep litter system) Straw added every 2-3 days, 3 kg per animal Constant level trough

Water from network (quality controlled water)

This isprophylaxis!

A A sanesane housinghousing

‘All-in All out’ Disinfected

Insecticide, virucidal and bactericidal

This isprophylaxis!

A A sanesane feedingfeeding

Food Baled hay on arrival Gradual shift towards a mixed ration

based on maize silage + concentrate (triticale, soybeans, grain corn, beet pulp, bran, minerals)

Fed once a day

This isprophylaxis!

A A completecomplete preventionprevention

The farmer manages the cattle as normal!

Weighing the day after arrival Vaccinations

RSV, BVD, PI3 , IBR

Deworming Ivomec D

This isprophylaxis!

4 days after arrival4 days after arrival……

13 clinical cases Allocation to 3 groups

Group 1: 13 clinical cases Group 2: 62 animals metaphylaxis Group 3: 92 animals monitored and

treated on a case by case basis

DecisionDecision criteriacriteria for for targetedtargeted metaphylaxismetaphylaxis

Sick animals (5-10%)Body weight < 270 kg« Farmer’s experience »

Groups 2 and 3 : a Groups 2 and 3 : a pertinent pertinent choicechoice

Weight is a major BRD risk factor

D 0 D 0 13 patients 13 patients 3 groups of animals3 groups of animals

Group 1Group 1 Group 2Group 2 Group 3Group 3

Housing of the 3 groupsHousing of the 3 groups

7 meters

7 meters

DD11

10 patients in Group 310 patients in Group 3

7 meters

DD225 patients more in Group 35 patients more in Group 3

7 meters

DD334 patients more in Group 34 patients more in Group 3

7 meters

DD662 patients more in Group 32 patients more in Group 3

7 meters

DD774 patients more in Group 34 patients more in Group 3

7 meters

DD881 patient more in Group 31 patient more in Group 3

7 meters

AtAt DD88

26 patients in Group 326 patients in Group 3

Complete prevention atComplete prevention at DD+14+14 ...and ...and for the for the restrest of the of the breedingbreeding timetime

7 meters

EconomicalEconomical analysisanalysis of the of the targetedtargeted metaphylaxismetaphylaxis

IndividualIndividual treatmenttreatment costscosts

Prevention is better than cure... And cheaperalso!

17,63 €3,64 €10,62 + 3,37 = 13,99 €Curative

13,19 €2,57 €10,62 €Metaphylaxis

Global cost per presentanimal

Manpower cost per presentanimal

Treatment cost per present animal

250 kg

TargetedTargeted metaphylaxismetaphylaxisisis profitableprofitable

Treatment cost per present animal

0

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8

10

12

14

16

18

0% 5% 10% 15% 20% 25% 30% 35% 40% 45% 50% 55% 60% 65% 70% 75% 80% 85% 90% 95% 100%

Percentage of sick animals in Group 3

€ /

pre

sen

t an

imal

Global metaphylaxis

Targeted metaphylaxis + curative x%

Targeted metaphylaxis

The curative case-by-case managementis permitted thanks to

ZACTRAN PK/PD parameters

ZACTRAN allowsallows a more profitable monitoring of a more profitable monitoring of

BRD BRD outbreaksoutbreaks in in youngyoung cattlecattle fatteningfattening herdsherds

The « classical » strategy Curative treatment on sick animals+ Metaphylactic treatment on all the others

A new strategy thanks to ZACTRAN PK/PD parameters Curative treatment on sick animals+ Metaphylactic treatment on some* of the others+ Other animals monitored and treated on a case by case

basis

* Decision criteria<270 kg body weight for instance

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Great thanks to Maurizio Bonfanti

TherapyTherapy

EfficiencySafety

Practicality

ItalianItalian fieldfield ssttuuddyy

Aimo ZACTRAN vs Tulathromycin in BRD treatment

24 Limousin 24 Limousin heifersheifers withwithseveresevere BRDBRD

Date of arrival: 3 December 08 Prophylaxis on the first day after arrival

IBR, PI3 ,BVD, RSV Ivomec Plus

Trial start BRD outbreak

End of the trial 14 days after treatment

Avanti, avanti...Porca miseria... Limousines...

24 Limousin 24 Limousin heifersheifers withwithseveresevere BRDBRD

ZACTRAN group 13 animals

258 ± 32 kg

Tulathromycin group 11 animals

259 ± 33 kg

ZACTRAN group 4/13 relapses

Tulathromycin group 9/11 relapses

D1

ZACTRAN group 13 animals

258 ± 32 kg

Tulathromycin group 11 animals

259 ± 33 kg

D2D3D4D5D6D7D8D9D10D11D12D13D14

Less reLess re--treatment in treatment in zactranzactran groupgroup

TherapyTherapy

Excellent results In line with many reports from

clinicians Profitable

Less re-treatment Less manpower needed

ProphylaxisProphylaxis, , metaphylaxismetaphylaxis & & TherapyTherapy

ZACTRAN allows new BRD management strategies Thanks to it’s PK/PD parameters

Fast acting Long lasting Huge concentration above MIC

Curative Metaphylaxis

Profitable thanks to less mortality Safety

AcknowledgementsAcknowledgements

Andy ForbesYou all here

Thanks for your attention

Any questions?