1 imaging the awake animal positron emission tomography d.j.schlyer, c.l.woody, p.vaska, v.radeka,...
DESCRIPTION
Timeline of Bioengineering Projects 1999 – Start detector development for measuring blood radioactivity non-invasively with BNL LDRD funding and later with a CRADA with CTI, Inc. 2000 – DOE Biomedical Engineering grant for the beta microprobe 2001 – Expand the project to include the microprobe, motion tracking and imaging the awake animal. Received DOE funding for 3 years. 2003 – first electronic chip sent for fabrication. Received two NIH (NIBIB) grants for parts of this research effort. 2004 – First prototype of the animal scanner with the ASIC in place. Extension of DOE funding.TRANSCRIPT
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Imaging the Awake Animal– Positron Emission Tomography
D.J.Schlyer, C.L.Woody, P.Vaska, V.Radeka, S.Stoll, P.O’Connor, J.-F. Pratte, A. Villanueva, B. Yu, R. Ferrieri, M. Schueller and N. Volkow,
Brookhaven National LaboratoryS.Shokouhi, A.Kriplani, S.Southekal, S.Krishnamoorthy, A.Dwivedi,
Stony Brook University, Brookhaven National LabI. I. Rampil, C. Page, D. Samaras, Y. Wang, W. Zhang
II. Stony Brook University III. R. Huesman, J. Qi, G. Klein
IV. Lawrence Berkeley National Lab
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RatCAP - Rat Conscious Animal PET: Allows the effects of anesthesia to be assessed
The Problem: Current small animal PET imaging instruments are limited by the need to use anesthesia which can profoundly depress brain function.
The 9th International Conference: Peace through Mind/Brain Science
The effect of anesthetics on the uptake of β-CFT on the dopamine transporter of the monkey brain.
The effect of different anesthetics on the uptake of [18F]Fluorodopa in various regions of the monkey brain.
D.B. Stout et al, UCLA 1998
Timeline of Bioengineering Projects
1999 – Start detector development for measuring blood radioactivity non-invasively with BNL LDRD funding and later with a CRADA with CTI, Inc.
2000 – DOE Biomedical Engineering grant for the beta microprobe
2001 – Expand the project to include the microprobe, motion tracking and imaging the awake animal. Received DOE funding for 3 years.
2003 – first electronic chip sent for fabrication. Received two NIH (NIBIB) grants for parts of this research effort.
2004 – First prototype of the animal scanner with the ASIC in place. Extension of DOE funding.
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RatCAP - Project Collaborations lead to valuable expertise in related fields
These projects are a collaboration
between several departments and divisions at BNL,
SUNY Stony Brook and LBNL
Weekly meetings within BNL, e-mail
and telephone contact with
outside collaborators
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Biomedical Engineering Projects
RatCAP (Rat Conscious Animal PET) Input Functions for Modeling
– Wrist Scanner– Microprobe
Motion Tracking Motion Correction Stress assessment
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Summary
Basics Physics and Engineering are being applied to Medical problems
The Expertise at BNL can be applied in many ways