01 - lww journals - beginning with ajournals.lww.com/anesthesia-analgesia/documents/chinese... ·...
TRANSCRIPT
!
!"#$%
"
&'(
!
!"#$ ) #! *
!
+,-
!"#!!!
!"#$%&'()*+,-./01
!"
23
"#"
456789$%:;<=>
!
!"#$%& '( )%"*+,+
!
-./
!
01-
!
,+2 3%4+5 6( 01,7
!
)8
9+:;$%*:&< "= >,?:="%+:,
!
-,;:*
!
-,;:*
!
>,?:="%+:,
./
!
01
!
!"#!$%"&
!
%&'()* +,)-,+./ 01
!
"
'#$%(& 2
"
)'
"
3
"
*+,-.(/%/ )*0+12,3
#
!"#-.45/% 2435 .(670
$
1238,-9:
$
; 01
!
45<=>-"?6 2435 .(4@
#
78A(B!
"#! 01
!
CD9EFGH:;IJ+K!
$
)-<=L>03M=?@3,39:
$
(>?6 2435 .(4@NA,#
CDOK!%
#
23
!
2435 .(0PQR<=CS
$
TUV@WXYXZ[\B
#
ACDEF7: 01
!
!] 01
!
N^_
2435 `a+8,-IJ
#
CD?O!"#
%
6
7
%
01
!
!bcd+IJ
#
`aef
$
gCG 2435 +?6?@
$
A@h!
i"H#OI$+ 80
9"
#
45
!
%J 2435 &K+4@?6;J7LHMNj!k:l5 9"
$$
OmKn': #:! 80
9"
+
$PQR60
#
#:! 80
9"
$PQR60ST9 2435 .(4@+oC'f
$
1J%U
!
pVq
%
;3
$
! < 9 = > QR<=:W
"&
? 01
!
7 6
7
!
9#
$ %
9
$"$
01
!
7!"#
!
9@
$ %
9
$"$
6
7
7 !"#
!
9#
$ %
$
$"$
01
!
7 bcd
!
>A
$ %
B
$"$
6
7
7 bcd
!
>@
$ %
!
$"#
46
!
X<=rY+L>(sZ)
$
01
!
!!"#G 2435 .(+?6?@:ZK;`
#
O#+[6-
$
01
!
-"(&9 2435 .(+ C6 \]*+
$
^;tu9 DEF2# v'N8,-9:+,!%
#
_;
$
bcd-O`! 01
!
w
O`X 6
7
ax.3?@?6 2435 .(
#
QR?@+,3[6/bG.(+ZKc.3?@
#
,#0s145ZK?@2
sde0Cf[6+33%
#
!"#$%&'$
!
(!)*+,-./01
@*"=?4%,+$ ,+2 A,%#"+ 2:"B:2$ C>D
E
F +$5,&:;$?< 7"24?,&$ G
"
7$&1<?
"
-
"
,*H,%&,&$
I CG/-JF %$A$H&"%* K #4& ;:, 2:==$%$+& 7$A1,+:*7*( @*"=?4%,+$ :* , A"7H$&:&:;$ ,+&,5"+:*& ,& &1$ G/-J %$A$H&"% 5?<A:+$
#:+2:+5 *:&$K L1$%$,* >D
E
:+1:#:&* G/-J %$A$H&"% A4%%$+& &1%"451 $B&%,A$??4?,% ,A:2:=:A,&:"+( @*"=?4%,+$ ,+2 >D
E
$B1:#:&
,22:&:;$ 7:+:747 ,?;$"?,% A"+A$+&%,&:"+ $==$A&* :+ %,&* K #4& L$ 1<H"&1$*:M$2 &1,& &1$< L"4?2 +"& ,22:&:;$?< :+1:#:&
G/-J %$A$H&"% A4%%$+&* :+ ;:&%" #$A,4*$ &1$< ,A& ,& 2:==$%$+& 7"?$A4?,% *:&$* (
2345-061
G/-J %$A$H&"%* L$%$
I $BH%$**$2 :+ =%"5 ""A<&$* ,+2 *&42:$2 4*:+5 E
"
$?$A&%"2$ ;"?&,5$ A?,7H &$A1+:N4$*( J 5?<A:+$ A"+A$+&%,&:"+ %$*H"+*$ ="%
G/-J L,* 7$,*4%$2 :+ &1$ H%$*$+A$ ,+2 ,#*$+A$ "= >D
E
( >"+A$+&%,&:"+
"
%$*H"+*$ A4%;$* ="% :*"=?4%,+$K O
P
K >D
E
K ,+2
Q$&,7:+$ ,* , =4+A&:"+ "= G/-J :+1:#:&:"+ L$%$ 7$,*4%$2K ,+2 , O:?? $N4,&:"+ L,* 4*$2 &" A,?A4?,&$ &1$ R>
ST
="% $,A1
A"7H"4+2(
,36.7461
):+,%< 2%45 A"7#:+,&:"+* A"+&,:+:+5 UVE R>
ST
L$%$ ,22:&:;$ := G/-J A4%%$+& :+1:#:&:"+ L,*
I +"& *&,&:*&:A,??< 2:==$%$+& =%"7 ST
$
( 31$ UVE R>
ST
#:+,%< 2%45 A"7#:+,&:"+* 2$A%$,*$2 &1$ H$%A$+&,5$ #,*$?:+$ G/-J
%$A$H&"% A4%%$+& ,* ="??"L* C7$,+
%
8-
K ! WS &" X ""A<&$* $,A1FY >D
E
P O
P
CSU
$ %
S
$
FK >D
E
P :*"=?4%,+$ CSZ
$ %
[ S
$
FK O
P
P :*"=?4%,+$ CSU
$ %
\
$
FK >D
E
P Q$&,7:+$ CX]
$ %
^
$
FK ,+2 O
P
P Q$&,7:+$ CXZ
$ %
E
$
F(
)-/)7.68-/61
@+ A"+&%,*& &" "4% 1<H"&1$*:* K G/-J %$A$H&"% :+1:#:&:"+ #< >D
E
,+2 :*"=?4%,+$ :* ,22:&:;$( 0"**:#?<K >D
E
,A:2:=:A,&:"+
7"24?,&$* , HO
"
*$+*:&:;$ ?""H "+ &1$ G/-J %$A$H&"% &1,& :+ &4%+ ,?&$%* 5?<A:+$ #:+2:+5 ,==:+:&< "+ &1$ _?4GU *4#4+:&(
O"L$;$%K Q$&,7:+$ H?4* $:&1$% >D
E
"% O
P
*<+$%5:*&:A,??< :+1:#:&* G/-J %$A$H&"% A4%%$+&* ( -%45* ,A&:+5 ;:, 2:==$%$+&
7$A1,+:*7* A,+ &14* $B1:#:& ,22:&:;$ "% *<+$%5:*&:A %$A$H&"% $==$A&* ( J22:&:;:&< 7,< +"& %"#4*&?< :+2:A,&$ A"77"+,?:&<
#$&L$$+ 7"?$A4?,% ,+$*&1$&:A 7$A1,+:*7*(
"
"!#$%& "!'() *+,,- ,,*. /01
#
23
#
!!!"
!
#$%"&'#$(#$&'!)
"*%+
!
&',(#$)-./%01&"*2
#)3$45+%#$,'!()6")
"
80
9"
#
-
7*'
$
#
%
&
.%8+,9
!
%.#$:-/;0<
$%!!!!
!
!"#$%
"
&'(
!
!"#$ ) #! *
!
+,-
!"!!!#$"%&
!
'!""(#)$*
+
"
!
#
$
#
$
,-).
!
##/01$%"&/012'
'%34"%&
"
%
#
&
#
$
5()*+678/019&'#,:;(<
+)-+=
$
$$>.$$;%%?.%&!!"
*; ' + !
"
,/'-
%
!
"
()*+,-./01*2 (2*3 /045 '6
7'8'
'
&
>(,-@(%3)$*+
"
9
#
$
0AB.
)*C*+/1 :;<' @(*+;!"
!
"$D/
010>.$$2"(E. :;<' @(,&;)$
*+
"
9
#
$
1##&/012'3>F4G3H?$
%5I4"(# :;<' @(;,)J
!
KL.$
$
'
-$$>6$$
"
=
#
$
.MN6
!
7/,O!"!#4%&;/01
P536"(4"*+
"
>
#
!
-OQR
!
I5,O)
$%&89/01;%&!#
$
#S3T,O(<
7:01589:
!
;<C=U;73(./01
9&'#,:CVW%&;H?
!
/019&'#
,:>I>/01<J;*6DCX
!
YZ :;<'
@(
"
?
#
$
?=[2
%
@A
!
&
>>'#
%
B
C
&
5>F-
[!!<?@\1@D]A :;<' @(
"
#"
#
$
.$
$!A+3B 4B
!
1P4.D6N(,-)%B
^(# :;<' @(;CI
"
##
#
$
2'3>FDC_
X5,:
!
`abC,Dc
!
S16- :;<' @
(
"
#!
#
$
2'3N!!.d/C!e38)%B
^
"
#!
#
!
fF :;<' @(;g/7+>F`a"$
D/01;9&D
!
1!hi2'3;%&
"
#$
#
$
j-;<EF @A
!
> B
C
'
.$$k2'3
!
>%
# $ GHl;7m/
!
Hj $ G!"n#!#(#
:;<' @(
$
;<I#H?o.,O"3!#4*
;
!
YZ @A
!
C B
C
!
>F%&)$;(# :;<'
@(,:
!
0<%&6!"n#B^;
!
YZ
@A
!
C2'3_p @A
!
C .$$
!
1>F$"4"
*+
$
J;7;K38q;N689!"!#;/0
1N$%L&1P5>F4"(# :;<' @(
$
@A
!
> B
C
;)$%&E#MD.NF
$
2'3n
G> @A
!
'
B
C
E#4"%&;MD.NF
$
"&
/01 @A
!
>.$$%&!#!"
!
;<I#+O
4"(# :;<' @(
$
J;7K?8q;N6P
6 @A
!
. :;<' @(d9,->(,-)%:^
;%&
!
r,VW%&65(:^;.$$)
Ys
$
.
!!
/
"#
0123456789:
HQ$tRu;v<n2I?ST>+&Uw
xVW;;7yJ
!
z3X=DK>?@
!
LMY
N{/0
!
|}zE%A
$
& "
&
!
$
"+BZO3B
%
CDP3[
!
EFGH
!
~I3t
&!
%&!!S
�6JO;AKQ<3B=
$
3BRC >>)),DEF
:(@D
'
#)),DEF G@D
'
!
&
%)),DEF :(B@A
$
'
!")),DEF
BHIHJ
'
"
&
>!)),DEF ;KJA
%
'
"
&
$$)),DEF @(
%
:A
$
&
!
'
"
&
%#)),DEF @(@D
!
'
&)),DEF [3-L
'
MRN
S
'
ONS>PNS
!
]A 4B L =
&
%
$
fC;T>
-3S5# 'M @M JM \
%
UQ!�u
!
4"#
!
$
t
&$
�� 7D.:# :;<' @(g/\ 4@<:' VRF
5]�
!
RS; :;<' @( 7D.:!' g/2P\
48JNN GJ VRF5
!
?p%j�HW
(
&^<_`
%
��HFa<Ru
!
6<'
&
()
!
;<bc"d
&X
$
VRTD[�
!
;<L& O= ef71U
%
);5PP(K5 );(2Q*+5
!
')-*,+ g*
!
HFa<t
&
%o 2R:'
$
h�8g/; 2R:' i"�Y�%%
!
& <HI@ �lO;jVY� #)KE)D kl-
$
&m7
##nB8
%
:(+,S52/#
!
H+,H�u
!
81,,)(DD
!
I'
&
zE ?+D _ #>+D ;ef%%?_j
%
.NF
&$
# T ! Z�
!
S�%&!!;,3l;7
$
$#
;<=>?.@
J�:�&;,3l�}>9:�:;yJ)
;
"
#"
!
#%
#
#9
#
$
h%&!![6 !&"$D \&W#�
!
F
#H-
%
$$ +-
!
&.<8
!
B,DD*P/,+
!
;'
&
�]-
&R/O@0�3B
%
8(UR
&!
X/ #
&
& )DE)*+
!
3
B F o # ##&)),DEF :(@D
'
!
&
&)),DEF G@D
'
#
&
>)),DEF 8(@D
!
'
#")),DEF BHIHJ > "
&
#)),DEF
H7O'
!
JO
!
]A 4B L =
&
%
$
##8>7o^L&
12_ IOUH #p
!
�eq314Y
"
#=
#
$
L&_W
=,Z,�5�}
%
75+5@D()4 &""8
!
'V,+ <8
!
�67
!
@'
&
v�.,�# >")W
$
`r& 8(UR W
#
!
st & n>/T�
!
a&[I13B
%
8(URH7
&
W# $" 8
!
3B# 8(UR $ "
&
#)),DEF 9,-
%
H
&
> "
&
"#)),DEF (,-
%
7
&$
b�& 8(UR \] & n
>
$
-Ou�v $ T % "
!
:w.N[I1-+;*
6D
%
9,&A+ X #"
$&$
8(URH7 J�c>?4
!
!"#$%
"
&'(
!
!"#$ ) #! *
!
+,-
!$&!!!
!!"!"# %&
$
$!!""
!
#%&'$"#%&' '()*
"
$% ! (#
"
(
#%&'$"#%&' '()*+, $#
"
)* $" !
!
+,- '()* &% - (#.)%&'
"
($#
'()*+, )* $" !
!
*/+ ./01 0$"""#1
$"#%$%,,$$2!#"
$
-
"
3.%/%0
&'(1
!
%/4-"#%/42'&
#
23(45
"
3 -
'
"
10 ()
"
5$%67 67489:6
"
2;
$
89'4
!
%#
!"./0123456
3/$$"#%- #""<= *(&'#))56
"
:7#))&' -"<= (8 '()* ;<(8 '()*+,
"
=+)>9$#))?@A**B=C$
!
:(2
+$"#%- %%
&
%%%
$
(* 2;
!
#
/(53>6?9 @48:(6
"
),-
"
21
$"
A2;
!
;D<-E+,-.$(1(
**F,= !$
'#
1'B-
"
GH-)DI
"
C>65=(D>
"
;E
$!
#%J&' #<?=FB E2= KL 7E $"#%M
--*(;> 7E
#
1GGH<>5 IB!"
"
/.+5N
"
,
01
"
O-?.7
$!
@./#%$K6B&' -"<=
#
(/8A
"
BQE ! 7R*231
@.//2)$45
"
0122 $" !,6S3/%
CT.$
"
(UD % E3F78
!
",G! #
&
$ (#
H0-V
"
;>%CT@./.$$**
"
<-3
,5-*$.9:;(
#
2=(4H6 -""
"
A>4D89 +=<>4
"
C(=53(<
"
/1
$"
"
&
!-<= ,I<J
"
$< J)
"
%K 41
4 3 234?<(6?4L CEA = 5 6
#
A>4D89 +=<>4
"
C(=53(<
"
/1
$"
>"5 $-<=F<89
"
2WF."5
$-"<=F<89
"
7$8*HX #-"
'!
/K@./**
YLZ?/.=:;M-6[7%&'.$(1(
;>
#
19M4?6 N&""
"
BH<(J>96>
"
J(95(2=(4(
"
21
$!
<-*(#))@\#)%&']^_(8$$"
%J.] #FN !.`$@./**
!
<-$@%ab
GNcA8B!O.]$P9C3D
#
J8:<(
"
J5O
B?H86
"
/;
$
#%
!
Q9+'"#R7E$4(d;> ./01 0$
"#
"
.] 2;
!
%
@./eC3D$ ./01 0$"
"$@A**
#
"#:7
!
5+fOF-gG7h
36
#
P
&
##
"
JAJJ
"
238G(:?
"
QB
$
$%/
!
i=
2;
!
> ./01 0$$j-S! 7E Hk
&
#"
'
"
3Z>
E
R
$"#*;>\IJl:%"!"#E
"
Z;K
7h36TLU>VM:7K**
#
Q2
-"
$"
+,IN
S"!7Km#
!
=&m#n"J
"
WXK6oO/:Yn"2
8A$#%
"
**=8E$ Q2
-"
!
pq$<$#%Z
Z)>/8
"
:Y28A$**= Q2
-"
$ #F!
!
;>
:P/8@A>9\"`;=>!!T ./01 0$
Sr$st
"
>: -"
$
Sr""7K=u1@A=
&j-
!
vpj->:==;j-Qw S -"
$
$7
Km[
"
! \"]^h_V= "!"
&
"-
!
&#
789:;89<=>?@A56
;>?RS**e@RST**x<U>=>
!!_!! ./01 0$Sr$"#
"
yU"< 2;
!
j-g ./01 0$$?RSe@RST`8aV$
IW
!
;>O/ " ; #T<<E:2;
!
$#%$#%?"
#
"
X>**= $T
'"
E+Y.(1
!
?RS**
"#e?RS"!** "
&
#<<?=FB $**"#dz
!
@RST**"#e@RST"!** #<<?=FB $
**"#dz
!
-5+fO>%/89G7h36
"
MIN"!Sr"""#
#
+
<(U
$%
/m9+**JE
#
+2
-"
$%
5+c%
#
9
E
$
e8EZ L??5654(7 fM{I
$,5=
&
#&
'
!
/2 2;
!
$TLb%dz1 ! \" " V
"
&
"- -0A=Z@/]^h
!
|[ 2;
!
}]^[B~9+'$ +2
-"
�B�c
$ +
<(U
"
�d\ 2;
!
>9+BW/CDh7Kj-
!
U]^��9+'$ +
<(U
��c$ +2
-"
�d\u1
GCDh7Kj-
!
|[ 2;
!
]^��o +
<(U
M]B
~9+'$ +2
-"
"
�\>9+BW//87K
j-
&
#%
'
!
B
!!
C
2;
!
%
E
R
%
@./eC3DML7K ./01 0
$Sr""
!
,I)*g%&'J$_!!Sr"
#ef #
"
8Yn"@A$**
#
"#:7ef !
!
ZYZ8E #F! Q2
-"
/8$@A> ./01 0$S
r$j-m[ed #
!
2;
!
e E
R
> ./01 0$/=
pj-gK
"
^8,7Ko -#
$
$_!!Sr�J
l$=&j-=h
#
f $
$!
��dz
"
2�B 2;
!
i
B E
R
��pj-gK$#)%&'C3D^8
"
7
Ko KN
$
W KT
$
$_!!Sr
"
h8j>$vpj
-
!
�B
"
2;
!
%
E
R
e>'h%&'@./^8d
�==&j-
#
f $
$!
1N7 & =>!!$_�n"
J
"
#FN +2
-"
$ 2;
!
& $FN +2
-"
$@./7K N%
$ %
!
$
$ ./01 0$
"
pqd�==&j-
!
9+'?RSe@RST$ ./01 0$**
#
$'!!!!
!
!"#$%
"
&'(
!
!"#$ ) #! *
!
+,-
!!
.
"!
!!"!!"#$"%""#!!$"# %&'( %"
#&"#$$#
$
!
'%&&'(
"
)
#
('&'
"
*
#
$ +,
"
$)%%("#
$
&$)"'* %&'( %"#&"#$%+
",&*
%
%-./% -.
!
%
($ /
%
))**0+
!
$
-.
!
12*3,&&'(4-
"
)
0,1
#%
5/.&
&&'($ )-
2"
%
67 -.
!
8 %&'( %"$&&'
.
$!
!!"!!!!/0$ -.
!
"
(
#&
34
"
+
#&
&$)
"
-
#
(+',
"
'
#
- %&'( #&"#
$
!
12(.*/+3 5-
2"
4$05.
$
(
&
-
&
' '')(96
"
**(+ #
#
:;
$
12 %&'(
%"8<! 6#7"0048 $&$)3"",
(+=$4,->%+?@A7
$
-.
!
BC12*'
&'$ )
0,1
5DE.F* )-
2"
$
6EG5 -.
!
8
%&'( %"$'&'+=*-+8%+?@
$
&&
'(('&'$ 9 &*))$)(H*6 6 #
%
+3
9IB(7
$
5D
%
:-'&'J -.
!
'KL.&
*IB(78;9=
$
/
"!
J !$
'
,:;(7M",*<')(964*><-
9=NO$ %&'( %"3,%+4,
"
5
0,1
#&
P=%+/>
"
5-
2"
#
'Q)(H*
"
:
4
#
(7M
5
0,1
5-
2"
:
4
!
-.
!
#""
%
! 7
&
2
%
"
&
/ #
&
/#
%
"
&
";
!
4
<
#"" #;$
%
= />0
&$)
"
0048
#
#""
%
2 2"
&
>
%
/
&
; #
&
!2
%
"
&
"7
!
+',
"
$0?@AB
#
#""
%
! #
&
//
%
"
&
"> #
&
$/
%
"
&
#/
!!
$
!
?@./>$ 5-
2"
DRSA 34 = 5-
2"
$*<?0B*><
-1TU$
'
VW 34 =4,$)(H*/X>0
0
!!
1
-.
!
( 4
<
#YAB@+'AA4,%+ %&'(
%"#&"#
(
#"
)
$
-.
!
(+',
(
#!
)
#Y/B@+%
!
!"#$%
"
&'(
!
!"#$ ) #! *
!
+,-
!$"!!!
!!
.
%!
!"!# #%! &'
("
$!!""%&' )*+, ("
#)*#!"$$+,
!
-#.$#$#!%"-
"
&
#
%'%($%)&%
$
*'&/0'%1(2"
%
&/3 ("
$
$ )*+, ("#)"$
$
+',#-4$&/
.' .("
$%
)"562"
$
!&$% )*+, ("#)"
$&//7 ("
$
/
$!
("89" /0012 !0:'(12 )*+, ("#)
"$;*<=
!
3
045
"&
>3<=(4
!
3'
("
"
?)"@
%
!
6
1
"
)50
'7
!
!
!$
'"
3
045
3'
("
!
$089%:
"
6
1
*678 "0012 #""
%
# ;
&
#!
%
"
&
$! #
&
$"
%
"
&
"/
/0012 (#
%
! ;
&
(-
%
"
&
/" #
&
!"
%
"
&
!"
+67 "0012 #""
%
# "
&
<#
%
"
&
"$ #
&
;;
%
"
&
"<
/0012 (#
%
! #
&
-=
%
"
&
"/ !
&
/"
%
"
&
;=
!!
&
#
#"%*+ABC6,)50#
!
*6788+67
"
("
D9"EF-%G.'HIJ'.
$
C*678#
%
'7
!
/KL;*
<0
!
3
045
"
D9,-M&/2"1)
$
C+671=$%
$
+67#
'7
!
KL 3
045
$62N.O3 3'
("
%
)"""&/2"
/ )*+, ("
%
:"3"G562"
$
.+/P,
4,-M0,0
%
2"Q )*+, ("F+671
R
'
##
(
%
'7
!
P2"Q )*+, ("F*6781R$
9,-;0,0
%
62NP2"Q+671R$"
"0,0
$
STUV
%
-5WX0
&
.+/Y '7
!
&/ )*+, ("#)2"P1($
$
ZE
%
67$
<=8>P2%$
$
94WX0?3#796[.
:/\32"
%
N+E1(2"$];^@("
A_
$
)*+, ("`<$=/a0<=>?966<
7$7MB4+E@"+67
%
CD' >1 bE
$
C
Ac%+$<FF
%
)*+, ("56G@HBId
67
#
e67
#
&67@"JRF
%
+67@"R
7'JQ ?9@)# `<F1f2g@(*$ Y*; $#
!!
.
&!
C !$
'&
("
!
,
"
89"
!
A
"
/0012 !0:'
(12
%
E38"h(KC$)50*678Y+67(
4D1=$ )*+, ("#)"$DL
&
#
D%E)"]EIM)/
!
-%F$ !
"%
%'%
($% 3(" 2$)&'
$
C*6781=$%
%
'7
!
KL
;*<0
!
3
045
"%
i9G0 3'
("
%
D '7
!
' )*+, ("
$*6781R$9,-M&/2"1)
$
C+671=
$%
%
'7
!
KL+67 3
045
$62N.O3 3'
("
%
$.
'7
!
' )*+, ("$+671R4G""&/2"
!j*$ ' 5
'
!"
#
!#
(
%
NGHO3\MWX0bE$
6<7BI
'
#$
(
$
kIJRPQi96Qlj'. (
!
B#/# m C!##
"
9+$#!j ?9@)# ^@B4
%
k
IB43 )*+, ("4G 1
D
bEM
'
!!
(
%
3 *$
"
*;
#!j*
!
Q6Q8=$+67@"JR
"
\4:
0
'
!$
#
!;
(
8nJ71fm *$ @(
'
!;
(
+E^@ >1 b
EM
$
8R+67@"1R$6<7BIN+_+
, 1
D
$ &'
("
%
op ?9@)# `<$ *! ,#qB
4
'
!(
(
$
r.F
%
9@"+67$ ?9@)!, `<F,
=$:0N+E'K$KL >1 bEM
'
!;
(
$
LM:/96
%
ikN[.$2"S+EOT
?-U.+/Y '7
!
:"+E2"1($&/
)*+, ("
$
7:U '7
!
Zs
%
+KLVP!$
)*+, ("#)$Q9Rt
'
!-
(
$
C("ub:8n
$$!!!!
!
!"#$%
"
&'(
!
!"#$ ) #! *
!
+,-
!"!#!"#$!%!$"""%#$#"&
!
%&&''%()#(&)*$(&+ %
&'(
"
' ) *
( !
#$
,*
!
*
+
#%-)./$&#+0%*
,-./# 1$(&+,+0+&,23
!
4($(&
'*56-7$(&+ %0
1"
"
( !
#!
.89/'(
)*5(: /234 ;"
%
##
&
-7$(&+ %0
1"
$
-
<
!
9015+&,=-> 05
!
* *
+
(: /234
;"2?@+3:
!
6* *)*5$(&+0(:A
).BC4DE
%
!)
&
$
FG)56%
!
7./H8E+ /234 ;",
*IJ+-06KLM9:3E-0;<N
$
1=
!
>?@@2IODE-0+3+4
'
/'(*5,
A
!
PAQ-+-0
#
B3!.R2SC6DE7
F+ 7 8!.
$
CT+
!
05
!
-0(GIODE-
0
$
U>%G/0.129H/#3&:)
!
45
VWCTX(
$
Y.
!
05
!
Z[I;+J&.).<
K&'29H
!
*=H*60HK\9&
$
]&
!
909:C^-0++0>;"+,_(
!
1)V
\$` ! 5LMIJDEKab>+C423Rc
?
$
$`LMIJ)d+ 80
1"
@
!
/234 ;"+,_
()DGKa+Z,3:+IJC423+"5)
V+NA
$
OP
!
LMH@B3 80
1"
+IJC2D
E
!
*K> 7 B-0
#
B3!.+Q3
!
)MeR
S01c?fCIJDg4M+C2DE
!
'IJ
Dg+,*
'
C4hiaDE
$
j>
!
FGTT #9!
80
1"
+IJE,kl)./
!
]m,*AIJ8nE
,U
!
)V\o"p5q8+C2DE
%
:
&
$
Ur./(<
!
IJ$`Ka+Z,3:DE
GstuF#,$!V$"ia23
!
9E 05
!
4
3+4
!
hv 05
!
4/'7
$
U#+0w.!+.
/+xC"y
!
stAKGzDEG;"
!
jVw
=-
!
9 ,4;4
4
;"
'
$(&* /234 .1;"
$!
%
:
&
$
%&
!
stADE+Z,3:K)VH"
{IJC2DERIJ
$
M"N
!
5WstI"K
ia23).$"2;+e(89B2-0
!
U|
X:GstDE+"#La0
!
YZU"0MMJ
}1-N.C[
%
!<
&
$
j>
!
90"NB3B""{
+IJDE
!
\OPP.C4DEG]QRIJs
t3:)V>K^C+
$
!
!"#
!
$
!
%&'
!
(
"
!
)&*+
!
,
!
-
!
.
!
/
"
.
!
/
!
'
!
0
!
!"#$%
"
&'(
!
!"#$ ) #! *
!
+,-
!$(!!!