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www.interscience.wiley.co m Antibase 2007 is a comprehensive database of 33,557 natural compounds from micro-organisms and higher fungi. Prof. Hartmut Laatsch, University of Göttingen

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Page 1: Antibase 2007 is a comprehensive database of 33,557 natural compounds from micro-organisms and higher fungi. Prof. Hartmut

www.interscience.wiley.com

Antibase 2007 is a comprehensive database of 33,557 natural compounds from micro-organisms and higher fungi.

Prof. Hartmut Laatsch,University of Göttingen

Page 2: Antibase 2007 is a comprehensive database of 33,557 natural compounds from micro-organisms and higher fungi. Prof. Hartmut

www.interscience.wiley.com

Content

Page 3: Antibase 2007 is a comprehensive database of 33,557 natural compounds from micro-organisms and higher fungi. Prof. Hartmut

www.interscience.wiley.com

Search Features

• Structure search

• Text search

• Search for properties

Page 4: Antibase 2007 is a comprehensive database of 33,557 natural compounds from micro-organisms and higher fungi. Prof. Hartmut

www.interscience.wiley.com

Case study:What are the typical biological sources of Antraquinone derivatives?

Page 5: Antibase 2007 is a comprehensive database of 33,557 natural compounds from micro-organisms and higher fungi. Prof. Hartmut

www.interscience.wiley.com

Page 6: Antibase 2007 is a comprehensive database of 33,557 natural compounds from micro-organisms and higher fungi. Prof. Hartmut

www.interscience.wiley.com

Page 7: Antibase 2007 is a comprehensive database of 33,557 natural compounds from micro-organisms and higher fungi. Prof. Hartmut

www.interscience.wiley.com

Case study:Compare the biological activity of Penicillin derivatives!

Page 8: Antibase 2007 is a comprehensive database of 33,557 natural compounds from micro-organisms and higher fungi. Prof. Hartmut

www.interscience.wiley.com

Page 9: Antibase 2007 is a comprehensive database of 33,557 natural compounds from micro-organisms and higher fungi. Prof. Hartmut

www.interscience.wiley.com

Case study: compound identification

•Optical rotation value of -270 degree

•Elemental analysis: nitrogen positiv, no sulfur, no halogen

•There is a CNMR spectrum with 17 C shifts

Page 10: Antibase 2007 is a comprehensive database of 33,557 natural compounds from micro-organisms and higher fungi. Prof. Hartmut

www.interscience.wiley.com

Page 11: Antibase 2007 is a comprehensive database of 33,557 natural compounds from micro-organisms and higher fungi. Prof. Hartmut

www.interscience.wiley.com

Page 12: Antibase 2007 is a comprehensive database of 33,557 natural compounds from micro-organisms and higher fungi. Prof. Hartmut

www.interscience.wiley.com

Page 13: Antibase 2007 is a comprehensive database of 33,557 natural compounds from micro-organisms and higher fungi. Prof. Hartmut

www.interscience.wiley.com

Case study: compound identification

•UV: 523, 510, 493, 257, 234, 212

•FAB: M+ = 825

•A HNMR spectrum has been acquired

Page 14: Antibase 2007 is a comprehensive database of 33,557 natural compounds from micro-organisms and higher fungi. Prof. Hartmut

www.interscience.wiley.com

Page 15: Antibase 2007 is a comprehensive database of 33,557 natural compounds from micro-organisms and higher fungi. Prof. Hartmut

www.interscience.wiley.com

Page 16: Antibase 2007 is a comprehensive database of 33,557 natural compounds from micro-organisms and higher fungi. Prof. Hartmut

www.interscience.wiley.com

Case study: compound identification

•HRMS 400,267

•IR 3500 1/cm (+ more peaks)

Page 17: Antibase 2007 is a comprehensive database of 33,557 natural compounds from micro-organisms and higher fungi. Prof. Hartmut

www.interscience.wiley.com

Page 18: Antibase 2007 is a comprehensive database of 33,557 natural compounds from micro-organisms and higher fungi. Prof. Hartmut

www.interscience.wiley.com

Page 19: Antibase 2007 is a comprehensive database of 33,557 natural compounds from micro-organisms and higher fungi. Prof. Hartmut

www.interscience.wiley.com

AntiBase is available in the database Formats:•ChemFinder (CambridgeSoft)•ISIS/Base (MDL)•SciDex (LCI Publisher)


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