william harvey day programme 2010

William Harvey Day ProgrammeTuesday 26 October 2010St Bartholomew’s Hospital, West Smithfield, London

Pub7093 William Harvey Day Prog v1_1 19/10/2010 12:22

Welcome to William Harvey Day

William Harvey Day will showcase some of the bestcutting edge research currently underway in Barts andthe London, School of Medicine and Dentistry and in ourpartner NHS Trusts. There will be nine presentations bySchool researchers, as well as three science “hot topics”presented by leading researchers who have recentlyjoined the School, and three guest lectures.

We are delighted that these will be given by Sir Tim Hunt FRS, NobelLaureate and principal researcher at the Cancer Research UK Clare HallLaboratories, Professor Sir Mark Walport, Director of the Wellcome Trust and Professor Marcus du Sautoy, Professor for the Public Understanding of Science and Professor of Mathematics at the University of Oxford.

The day will conclude with the Barts and The London NHS Trust’s traditionalannual St Luke’s-tide Service in the church of St Bartholomew the Great. I would be delighted if you were able to attend the Service, as this is atraditional and very enjoyable part of the day.

Professor Sir Nicholas WrightWarden, Barts and The London, School of Medicine and Dentistry


Venue information

The Great Hall and PathologyMuseumThe event registration desk is located just insidethe main entrance to the Great Hall and acloakroom is also available here. Coffee and Lunchwill be served in two separate venues; the GreatHall and the Pathology Museum (located in thePathology Building). Posters will also be displayedin both venues. To ensure you can view all postersand prevent overcrowding in each venue, the frontof this programme indicates which venue youshould attend for the morning coffee break andlunch.

Robin Brook CentreAll lectures and oral presentations will be takingplace in the Morris Lecture Theatre which issituated in the Robin Brook Centre. Please notethat once the lecture theatre is full, you will bedirected to either the Patterson Ross or BainbridgeRoom where the sessions can be watched on abig-screen.

St. Bartholomew the GreatThe St. Luke’s-tide service will take place in thechurch of St Bartholomew the Great at 6.00pmwhich is located 2 minutes walk from StBartholomew’s Hospital. If you are joining theacademic procession, your gown will be availablein the Great Hall from 5.00pm onwards.

The Butchers’ HallIf you have booked to attend the subscriptiondinner, this will take place at the Butchers’ Hall, 87Bartholomew Close. This is around 2 minutes walkfrom the hospital and is shown on the map at therear of this programme.

CPD ApprovalWilliam Harvey Day is accredited for CPD. In orderto claim the credits, you will need to sign the CPDregister in the foyer area of the Great Hall.Certificates will be available at the end of the day.

04 Queen Mary, University of London


Queen Mary, University of London 05

8:30Registration (Great Hall entrance foyer)

Coffee/Tea and poster display (Great Hall)

Posters will be in the Great Hall and PathologyMuseum for viewing throughout the Day

8:50Welcome and Introduction – Professor SirNicholas Wright, Warden, Barts and The LondonSchool of Medicine and Dentistry

Session 1 – chaired byProfessor Graham Hitman08:55Hot Topic in Science‘Flip-flops are best when paddling in Bile’

Professor Kenny Linton, Blizard Institute of Celland Molecular Science

9:10Oral presentations

‘Use of preclinical FDG-PET to predict outcomein response to anti-angiogenic therapy in twomouse models of metastatic cancer’Julie Foster, Institute of Cancer

‘Breakage of B cell tolerance by antigens onfollicular dendritic cells’Mohey El Shikh, William Harvey Research Institute

‘Mutations in C16orf57 and normal lengthtelomeres unify a subset of patients withdyskeratosis congenita, poikiloderma withneutropenia and Rothmund-Thomson syndrome’Amanda Walne, Blizard Institute of Cell andMolecular Science

09:55Year 1 Medical Student Research ProjectPrizewinner

‘The present and future of osteoarthritis’Rafae Shaikh

10:05Sir Anthony Dawson Lecture

‘How to avoid futile cycles: A new element in thecontrol of mitosis’Sir Tim Hunt FRSNobel Laureate 2001, CRUK Laboratories(Introduced by Professor Sir Nicholas Wright)

10:50Coffee and poster viewing (Great Hall & PathologyMuseum)Please refer to the front of this programme whichindicates which venue you should attend.

Session 2 – chaired byProfessor Mike Curtis11:20Hot Topic in Science

‘Unraveling the transport requirements of cargowaiting to leave the endoplasmic reticulum’Professor Carol Shoulders , William HarveyResearch Institute


‘The role of the receptor tyrosine kinase Axl inintercellular adhesion and signalling incutaneous squamous cell carcinoma’Monika Cichon, Blizard Institute of Cell andMolecular Science

Programme



Programme (cont)

‘Effect of folic acid on cognitive decline: meat analysis of randomised trials’Mark Simmonds, Wolfson Institute

‘The use of “Cell Sheet” technique enhances thetherapeutic effects of skeletal myoblasttransplantation with elimination ofarrhythmogenicity’Takuya Narita, William Harvey Research Institute

12:20Year 1 Medical Student Research ProjectPrizewinner

‘Anti-Platelet Treatment in Non-ST-Elevated-Myocardial Infarction’Nadia Taylor

12:30William Harvey Lecture

‘A century of inborn errors in metabolism: FromGarrod to genomics’Professor Sir Mark Walport, Director, Wellcome Trust(introduced by Professor Rod Flower)

13:15-14:30Lunch and poster viewing (Great Hall andPathology Museum)Please refer to the front of this programme whichindicates which venue you should attend for lunch.

13:15Alumni Association AGM and Lunch (PeggyTurner Room)

Session 3 - chaired byProfessor Nick Lemoine14:30Hot Topic in Science

‘Evaluating tests in the absence of gold standard’Professor Khalid Khan, Institute of HealthSciences Education


‘Macrophage ablation retards progression of anaggressive mouse Lymphoma’Simon Hallam, Institute of Cancer

‘Management of Cardiovascular multimorbidity’Sally Hull and Rohini Mathur, Institute of HealthSciences Education

‘Dengue virus replicon inhibits responses toLipopolysaccharide: Insight into a novel functionfor Stat2?’William Alazawi, Blizard Institute of Cell andMolecular Science

15:30Schorstein Lecture

‘The Secret Mathematicians’Professor Marcus du Sautoy, Charles SimonyiProfessor for the Public Understanding of Scienceand Professor of Mathematics, University of Oxford(introduced by Professor Mike Curtis)

16:20Prize giving for oral presentations and posters.Professor Sir Nicholas Wright



16:30The vision for the School of Medicine and DentistryProfessor Sir Nicholas Wright

16:40Afternoon Tea and Refreshments (Great Hall)

Academics joining the procession to StBartholomew the Great are requested to collecttheir pre-booked robes from the Great Hall by 17.30.

17:50 Academic procession leaves the North Wing

18:00 St Luke’s Tide Service (St. Bartholomew the Great)

The address will be given by the Rev’d ProfessorBernard Silverman FRS, Chief Scientific Advisor tothe Home Office, and the lessons will be read byProfessor Sir Nicholas Wright, Warden, and DrSteve Ryan, Medical Director, Barts and TheLondon NHS Trust.

19.15Pre-Dinner drinks reception (Butchers’ Hall)

19:45Dinner (Butchers’ Hall)

Grace will be said by Rev'd Professor NickGoulding.

After dinner speech by the Warden, Professor SirNicholas Wright, and a response on behalf of theguests.

The School is very grateful to the Barts and theLondon Charity for their support for the day.

Our thanks to Fulvio D’Acquisto and David Bulmerwho have very kindly agreed to judge the oralpresentations, and Patsy Munroe, Andy Stagg,Matthias Dittmar and Pedro Cutillas who arejudges for the poster display.


Poster Presentations – Great Hall


All posters will be displayed in the Great Hall andPathology Museum from 8.30am until 2.30pm.

Barts and The London NHS Trust1Contrast Enhanced Aortic DuplexUltraSonography Scanning (CEADUSS).Mr Shiva Dindyal

2Outcomes of a pilot roup using Mindfulness-BasedCognitive Therapy (MBCT) for people living withHIV and recurrent depression.Samantha Leaity

3Electronic Cytotoxic chemotherapy prescribingreduces prescription errors and improves cancerpatient safety.Dr Fiona McCarthy

4Who believes in oral HIV point of care tests? Asummary of 3 years experience and more than2000 OraQuick rapid tests.Nigel Garrett

5A new, highly efficient Aspergillus-specific PCR;DNA detection from histological material andbroncho-alveolar lavage fluid of infected patients.Gemma Johnson

6Can Apparent Diffusion Coefficient (ADC) PredictTumour Grade in Endometrial Carcinoma (EC)?Dr Nishat Bharwani

7An interpretative phenomenological analysis of thepsychosocial impact of HIV-drug resistance in agroup of gay men.Dr Dimitri Spiliotis

8Diffusion Weighted MR Imaging in the Detection ofPancreatic Neuroendocrine Tumours.Dr Chirag Patel

9Accuracy of main-stream end-tidal carbon dioxidemeasurement during stabilisation and roadtransport of mechanically-ventilated preterminfants with respiratory distress syndrome in thefirst 48 hours of life.Adel Abdelhamid

10Occult hyperfibrinolysis in trauma - a hidden killer.Imran Raza

11Evaluation of acute rehabilitation needs forpatients with traumatic injuries.Mrs Karen Hoffman

12Trauma associated cardiac injury and dysfunction.Henry De'Ath



The Blizard Institute of Celland Molecular Science13Exome sequencing identifies thousands of novelcandidate mutations in coeliac disease.Vanisha Mistry

14Avoidance of vitamin D deficiency in pregnancy:the case for a unified approach in National policy.Barbara Boucher

15Promoting the survival, migration and integrationof Schwann cells after transplantation into spinalcord by overexpression of polysialic acid.Juan Luo

16A ChIP-seq defined genome-wide map of vitaminD receptor binding: associations with disease andevolution.Sreeram Ramagopalan

17Flow cytometric functional assays.Gary Warnes

18The putative cannabinoid receptor GPR55 definesa novel autocrine loop in cancer cell proliferation.Roberto Pineiro Cid

19Development of a easy to use Super-ResolutionLight Microscopy method for visualising biologicalstructures at 50nm resolution and below.Dr A Wheeler

20A study of psychophysiological responses tovisceral & somatic pain in functional chest pain – acase control study.Adam Farmer21Loss of type VII collagen in SCC increases cellinvasion through TGF-beta signalling.Vera Martins

22Class II phosphoinositide 3-kinase regulatesexocytosis of insulin granules in pancreatic betacells.Tania Maffucci

23Oesophageal epithelial ASIC3 is associated withincrease in severity of symptoms in patients withgastro-oesophageal reflux disease (GORD).Yang Chua

24Do Fas modified drug-loaded microspheres treat apaclitaxel resistant cell line?Nader Ibrahim

25Early growth response gene – 2 (Egr-2) is antumour suppressor gene.Tizong Miao

26Personal exposure to back carbon in East London.Miss Clare Ewin

27Frequent co-existence of constipation and faecalincontinence: a greatly underappreciated clinicalproblem.Sahar Mohammed


Poster Presentations – Great Hall (cont)


28IL-7 and T cell receptor signals coordinatelyregulate γδ cell pre-programming and lymph nodeIL-17 production.Dr John Pang

29Phenotyping visceral pain in humans usingfunctional brain imaging introduction.Steven Coen

30The effects of eicosapentaenoic acid delivered asdietary treatment after spinal cord injury.Jodie Hall

31Gender differences in brain activity evoked byvisceral pain in healthy subjects.Michiko Kano

32Analysis of the molecular mechanisms mediatingBmi1 function in satellite cells.Xinyu Zhang

33The clonal origins of dysplasia from intestinalmetaplasia in the human stomach.Dr Stuart McDonald

34Switching between two distinct cancer stem cellphenotypes in squamous cell carcinoma.Adrian Biddle

35Is there altered somatosensory processing ofnociception in a mouse model of multiplesclerosis.Saira Siddiqui

36Infliximab therapy alters antigen presenting cellpopulation dynamics in Crohn’s disease.Dr Neil McCarthy

37The PcG gene Bmi1 regulates satellite cellsfunction in young, aged and myopathic skeletalmuscles.Valentina Di Foggia

38Isolation and characterization of neural stem cellsfrom the postnatal cerebellum.Dario Ceric

39Barrett’s oesophagus glands are clonal, containmultiple stem cells, expand by fission and share acommon progenitor with the surroundingsquamous epithelium.Anna Nicholson

4020-HETE exhibits two phosphorylation-dependentactions on TRPV1.Hairuo Wen

41A novel and selective PDK1 inhibitor reducesbreast cancer cell invasion and tumour growth.Claudio Raimondi

42Investigation of mechanisms regulatingPI3K/p110γ expression in pancreatic cancer.Richard Buus



43The utility of T cell receptor-like antibodies to targetHBV infected cells: the first steps towardsindividualised therapies for the treatment ofchronic HBV infection.Li Li

44The uptake of microspheres by breast cancer cells:improved delivery of chemotherapeutic agents.Mustafa Kadam

45An in vitro study of the potential stromal role inbasal cell carcinoma development through theinvestigation of GLI1 expression in basal cellcarcinoma derived fibroblasts.Jane Elliott

46The oncoprotein GLI1 induces an irreversiblebasal-like phenotype that confers androgenindependence upon LNCaP prostate cancer cells.Sandeep Nadendla

47Interferon-alpha mediates restriction of humanimmunodeficiency virus type-1 replication inprimary human macrophages at an early post-entry stage of replication.Kelly Cheney

48Bmi1overexpression induces apoptotic death ofneural progenitors during embryonic neocortexdevelopment through downregulation of Survivin.Serena Acquati

49The effects of Omega-3 polyunsaturated fattyacids on cell survival after injury in vitro.Stacy Gladman

50Characterising the steroid enzymes forendogenous cortisol synthesis in primary humankeratinocytes.Adil Jaulim

51Neural Stem Cells as therapeutic targets inGerminal Matrix Haemorrhage.William Dawes

52Retinoic acid metabolising blocking agentsincrease differentiation in squamous cellcarcinoma with loss of type VII collagen.Malcolm Avari

53Critical role of NaV 1.9 in the activation of visceralsensory nerve fibres by bradykinin but notadenosine.David Bulmer

54Validation of a new method for the assessment ofvascular endothelial function.Santron Sathasivam

55Gene Expression Profile during Progression fromPremalignant to Cutaneous Squamous CellCarcinoma.Nikol Mladkova

56Morphometric analysis of the remyelinated sciaticnerve after injury in knock-out C/EBPδmice.Hasanein Al-Hasani

57DNA methylation across generations.Michelle Holland




58Quantifying remyelination using high field (9.4T)magnetic resonance imaging.Dr Shoaib Ugradar

59High-throughput sequencing-based DNAMethylomics.Guillermo Carbajosa

60Different abilities of motilin and the motilinreceptor agonist GSK962040 to facilitatecholinergic and nitrergic activity in human isolatedstomach.Dr John Broad

61Bactericidal activity release profiles generated instatic biofilms are heterogeneous amongstdifferent strains of Pseudomonas aeruginosa.Richard Waite

62In vitro modelling of Basal Cell Carcinoma revealsa novel PTCH1-GLI1 signalling axis that isindependent of SMOOTHENED in humankeratinocytes.Muhammad Rahman

63Modulation of adipose core clock componentexpression in genetic obesity by metformin.Paul Caton

64ABCA12: a regulator of LXR-βmediated ABCA1expression.Daniel Poon

65EGR2 regulates inflammatory plasticity of effectorT Cells.Meera Raymond

66iASPP involvement in DNA repair in melanoma.Valentina Senatore

67Urinary free light chain excretion in primaryprogressive multiple sclerosis.Dr Ruth Dobson

68Asymptomatic Non Chlamydial Non GonococcalUrethritis in men is associated with high sexual risktaking behaviours: Symptom based triage missesmen at high risk for sexually transmitted infections.John Saunders

69iASPP/p63 auto-regulatory feedback loop isessential for epithelial integrity and autophagy.Anissa Chikh

70Clinical Trial: Influence of bovine colostrum onintestinal permeability in healthy athletes afterheavy exercise.Tania Marchbank

71Fingolimod enhances markers of remyelination inrat telencephalon spheroid cell culture.Samuel Jackson

72Understanding the tumour-suppressing activity ofrapamycin in epidermis.Katherine Sully



73Functional evidence for a protective effect againstHIV-1 and Mycobacterium tuberculosis (Mtb)infection from the Toll-Like Receptor (TLR)-8single nucleotide polymorphism (rs3764880).David van Bockel

74Factors within human inflamed intestinal mucosauncouple lymphocyte imprinting and regulatory Tcell generation by dendritic cells.Theo Sanders

75Organ specific autoantibodies in patients withadult onset diabetes.Mohammed Hawa

76Senescence in human Basal Cell Carcinoma.Muhammad Pirzado

77Trisomic dose of several chromosome 21 genesperturbs haematopoietic stem and progenitor celldifferentiation in Down Syndrome.Claudia Canzonetta

78A day at the mosque: finding culturally appropriateways to engage people in diabetes research by theNorth East London Diabetes Research Network.Gillian Hood

79Towards an understanding of the link between thelipid floppase ABCB4 and the lipid flippaseATP8B1 in the canalicular membrane of thehepatocyte.Michael Nicolaou

80Effects of the immuno-suppressive rapamycin onepidermis.Olufolake Akinduro

81Prospective randomized double-blind placebo-controlled crossover study of sacral nervestimulation in patients with severe rectalevacuatory dysfunction allied to rectalhyposensitivity.Mr Noel Thin

82Oxidative stress and senescence of balding dermalpapilla cells.Jamie Upton

83Early thymic T Cell Receptor signal initiation isindependent of receptor oligomerization.Joana Neves

84VZV replication and its association with keratin 15expression and Wnt signalling.Manuraj Singh

85Homeodomain transcription factors Pbx andPknox regulate location-specific epidermalbarriers via differential expression of LCE barriergenes.Stuart Brown

86The DSPII splice variant is critical for desmosome-mediated HaCaT keratinocyte adhesion.Dan Tattersall




87Phospholipase C signalling in cutaneoussquamous cell carcinoma.Emily Ruban

88Tissue damage activates an inflammatoryresponse in trauma.Joanna Manson

89Neutralisation activity in a geographically diverseEast London cohort of HIV-1 infected patients:Clade C infection results in a stronger and broaderhumoral immune response than clade B infection.Hanna Dreja

90Clonal evolution in Barrett’s oesopgagusdetermined by genetic diversity.Mr Shabuddin Khan

91Assessing the feasibility of a new method for thenon-invasive measurement of endothelial functionin conduit arteries.Miss Amandeep Mukal

92Induction of cellular senescence by miRNA co-operation?Cleo Bishop

93Monozygotic twins discordant for MS anddiscordant for serology disprove cytomegalovirusinfection implication in MS.Monica Calado Marta

94The tumour suppressor PTCH1 regulates EGFRsignalling in human keratinocytes: implications forthe treatment of basal cell carcinoma.Dimalee Herath

95A model of intrauterine hyperglycaemia providesevidence for fetal programming of glucosetolerance and a platform for epigenomic studies inmouse and human.Sarah Finer

96Identification of DNA methylation, histonemodifications and gene expression differences inMZ twins.Carolina Gemma

97Post entry restriction of MLV-B and MLV-NBcapsids in human cells is envelope dependent.Nidia Oliveira

98Identification of novel imprinted genes in humans.Lisa Nanty

99Using Next-Generation Sequencing to IdentifyNovel Disease Genes.Diana Blaydon

100Retinoic acid and aryl hydrocarbon receptorsignalling exert opposing effects on differentiationof human dendritic cells (DC) and their ablilty toimprint intestinal homing.Nichola Gellatly



101Circulating ‘gut-tropic’ Vδ2 T-cells are altered inCrohn’s disease patients and their siblings.Charlotte Hedin

102Genetic dissection of trisomy 21 pathology usingtranschromosomic cellular modelling.Dean Nizetic

103Can an ex vivo human liver biopsy model be usedto test the efficacy of drugs for the treatment ofhepatitis C?Alia Javaid

104Quantitative-PCR analysis of Fusobacteriumnucleatum associated with adverse pregnancyoutcomes.Cecilia Gonzales-Marin

105Inherited predisposition of oesophageal diseases(IPOD): A Genome Wide Association Study ofBarrett’s Oesophagus.Laura Gay

106Nano-antigen presenting cells (Nano-APC) for thedevelopment of therapeutic vaccines.Mengya Liu

Institute of Health SciencesEducation107Adverse events and manual therapy: A systematicreview.Dawn Carnes

108Maternal Vitamin D Deficiency in Tower HamletsPCT.Ameana Khan

109Progress on progress testing: Barts and theLondon’s initial experience of the UK Multi-SchoolProgress Testing Project.Patricia Revest and John Patterson

110Prescribing for Chronic Obstructive PulmonaryDisorder in general practice: exploring healthinequalities by ethnicity, sex and age.Alice Martin

111How do student’s best learn anatomy? Exploringstudent’s responses to the resources available.Mohammed Bajalan

112What are the attitudes of young people from ethnicminorities towards mental illness in different areasof London?Maryam Zulafkar

113Knowledge and understanding of HIV, AIDS andSTD among adolescents in Hamburg, SouthAfrica.Dr Jeannette Naish

114Evaluation of a practice based intervention toreduce health inequalities in chronic diseasemanagement.Ellena Badrick



115Back pain Reporting Outcomes Consensus(BaROC): a modified Delphi study.Robert Froud

116Collaborative working and UK NHS secondarycare for Chronic Obstructive Pulmonary Disease:impact of the UK National COPD Resources andOutcomes Project (NCROP) model of peer review.Carol Rivas

117Does prior exposure to clinical practice enhanceprocedural learning in simulation training?Rumman Ahmed

118Drug effectiveness at controlling type 2 diabetes by ethnicity and social deprivation.Gareth James

119An evaluation of the relationship between VitaminD status and quadriceps strength in patients withCOPD : a cross sectional study.Jonathan Fenn

120Identifying intimate partner violence in differentethnic groups in primary care.Alex Sohal

121Attendance and non-attendance at self-management courses.Dr Sharmin Shajahan

122Plagiarism: A study exploring the perceptions ofstudents and staff.Sinthuja Jeyarajah

123Carbon content of airway macrophages and lungfunction in children within the London lowemission zone (LEZ).Thomas Round

124Evaluating Doctors as teachers & educators –Does doing DATE as a student make a differenceto teaching practice after qualification?Faiz Anwar

125The representation of Government strategy andrisk concerning the swine flu vaccine in UKnewspapers during the pandemic period of April2009 to February 2010.Lakshmi Srikantharajah and Indarpreet Channa

126Investigating objective ways of measuring melaninlevels in order to study vitamin d status.Natasha Shrikrishna

127High-dose vitamin D3 during intensive phasetreatment of pulmonary tuberculosis: a double-blind randomised controlled trial.Adrian Martineau

Cancer Research UK128Whole colon field cancerisation in Crohn’silecolitis.Trevor Graham



129Stem Cell Niches in the Bladder? The ClonalOrganization of Human Urothelium.Nadine Gaisa

Institute of Cancer130FGF signalling and its implication in breast cancerdevelopment.Athina-Myrto Chioni



Poster Presentations – Pathology Museum

Institute of Cancer1Shotgun identification of substrates of proteinkinase Akt1 by quantitative phosphoproteomics.Luisa Beltran

2Systematic analysis of genomic alterations inprostate cancer.Xueying Mao

3Genome wide study of DNA methylation in AML.Marwa Saied

4Analysis of the inflammatory profile of DCIS inrelation to altered myoepithelial cell phenotypeand disease progression.Michael Allen

5Androgen-induced TMPRSS2:ERG fusion in non-malignant prostate epithelial cells.Nuria Coll Bastus

6Bone marrow failure in acute myeloid leukaemia isinduced by a block in differentiation of normalhematopoietic stem cells.Farideh Miraki-Moud

7Using a mouse model of Down’s Syndrome toidentify novel anti-angiogenic molecules.Marianne Baker

8An in vitro system to study the interaction betweenmacrophages and regulatory T cells.Juliana Candido

9SR-A promotes colitis induced colon carcinoma.Maud Bossard

10Towards targeting aVb6 in pancreatic cancer.Sabari Vallath

11Src inhibition in Renal Cell Carcinoma.Kevin Sharpe

12A non-replicating adenovirus expressing Hey1 iscytotoxic to prostate cancer cells.Katrina Sweeney

13Widespread epigenetic inactivation ofargininosuccinate synthetase renders lymphomassensitive to pegylated arginine deiminase.Barbara Delage

14Genetic profile of invasive breast cancervasculature.Dylan Jones

15The role of HAX1 in regulating avβ6-dependentcancer growth and invasion in vitro and in vivo.Chia-Yu Chen

16High-resolution genome-wide SNP analysissuggests a monoclonal origin of multiple prostatecancer foci.Lara Boyd



17S100PBP is ubiquitously expressed andmodulates the function of S100 calcium-bindingproteins in pancreatic cancer.Kate Lines

18The Pancreatic Expression database.Rosalind Cutts and Emanuela Gadaleta

19Investigation of the role of ZDHHC14 in humantumour development.Dr Marc Yeste Velasco

20Misbalance of Focal Adhesion Kinasephosphorylation enhances pathologicalangiogenesis.Tanguy Lechertier

21The chemokine receptor CXCR4 and malignanttransformation of the ovarian surface epithelium.Kyra Archibald

22In-depth characterization of the micro-RNAtranscriptome in Acute Myeloid Leukaemia withSolexa High-Throughput Clonal Sequencing.Silvana Debernardi

23Accumulation of 2hydroxyglutarate (2HG) inNormal Karyotype AML patients with IDH1mutation.Essam Ghazaly

24The effects of chemotherapy in combination withanti-IL-6 therapy on ovarian cancer cells.Vessela Vassileva

25Clonal selection of multiple TET2 mutations in thetransormation of chronic myelomonocyticleukemia to acute myeloid leukemia and itssubsequent relapse.Robert Petty

26An autocrine cytokine network in ovarian cancerthat influences patient survival.Hagen Kulbe

27AML1/ETO and the product of its target genePOU4F1 synergise to activate B- lineage geneexpression in t(8;21) AML.Jenny Dunne

28The Role of the Chemokine CXCL12 inExtracellular Matrix Remodelling in OvarianCarcinoma.Gemma Everitt

29Epigenetic regulation of miRNAs in Acute MyeloidLeukaemia.Floriana Manodoro

30Oncolytic vaccinia virus expressing decorin as anovel anti-cancer agent.Lynsey Whilding

31c-Met endosomal signalling and breast cancer cellmigration.Rachel Barrow



Poster Presentations – Pathology Museum (cont)

32HER2 regulates αvβ6-dependent invasion ofbreast cancer cells.Dr Kate Moore

33DCIS-modified myoepithelial cells promoteangiogenesis: co-operation of avb6 integrin andFibronectin.Dr Sally Dreger

34Targeting CCR4 in epithelial tumours.Dr Moddasar Khan

35Phosphorylation patterns that correlate withchromosomal rearrangements in AML primarycells.Pedro Casado-Izquierdo

36Is C-Met expression associated with prognosticparameters in invasive breast cancer?Colan Ho-Yen

37Changes in the microenvironment of DCIS: therelationship between altered myoepithelial cellphenotype and inflammatory infiltrate.Khairiya Ahmed

38Identification of adenoviral E1A gene regionsnecessary for sensitisation to cytotoxic drugs inprostate cancer cells.Hector Maya

39Investigating the role of FGF signaling inpancreatic cancer.Stacey Coleman

40FGFR2b prevents premature skin ageing andtumourigenesis in mice.Maria Monterrubio-Acebes

41Macrophage scavenger receptor A promotestumor progression through increased B cellrecruitment.Eleni Maniati

42The role of c-Met in breast cancer drug resistance.James Hulit

43C-Met trafficking stimulates Rac1 in breast cancercells.Ludovic Menard

Institute of Dentistry44Novel role of desmoglein 3 in the regulation of E-cadherin adhesion through Src signalling.Mandy Tsang

45Two independent mechanisms regulate keratinK15 expression in keratinocytes: role of FOXM1.Amrita Bose

46Effect of demineralisation solutions circulationrates on hydroxyapatite dissolution kineticsstudied using scanning microradiography.Hanadi Lingawi

47Developing a porous material to use as a bonescaffold.Jonathan Hatton




48Sequential microtomographic measurements ofenamel demineralisation inhibited by statherin-likepeptides.Dr Paul Anderson

49Surgical excision of an epulis, case report.Drs Gillam, Besas and Chatzopoulou

50Determinants of nicotine dependence in UK-resident Yemeni khat chewers.Saba Kassim

51Measuring the interaction between statherin-likepeptide and hydroxyapatite using liquid cell atomicforce microscopy.Farah Ahmed

52Immortalization of Oral human keratinocytes withdefined genetic elements in the development oforganotypic oral culture.Saira Athar

53Effectiveness of fluoride foams in controlling dentalcaries in children.Dr Akash Jain

54The oral health and microbiota of UK Behçet’sdisease patients.Noha Seoudi

55The effect of omega-3 polyunsaturated fatty acidson normal and neoplastic oral keratinocyteapoptosis.Zacharoula Nikolakopoulou

56The candidate tumour suppressor HOPHomeobox (HOPX) is up regulated in humankeratinocytes independently of DNA strand breaksand senescence.Alice de Castro

57Immune responses to cytoskeletal proteins inBehçet’s disease patients.Mojgan Hamedi

58IgG subclass distribution of total and antigenspecific antibodies in Behçet’s disease patients.Lesley Bergmeier

59Neutrophil Elastase and Secretory LeukocyteProtease Inhibitor: Investigating their role in thesaliva of Behçet’s disease patients.Tanya Novak

William Harvey ResearchInstitute

60Inflammatory cytokines induce pericyte shapechange in vivo: role in facilitating leukocytetransmigration?Doris Proebstl

61Development of a latent IL-17 antagonist foreffective gene therapy of rheumatoid arthritis.Gayatri Mittal


Poster Presentations – Pathology Museum (cont)


62Gene expression and whole epigenome analysis ina model of foetal programming: the effect of folicacid.Gioia Altobelli and Irina Bogdarina

63Generation of Schwann cell specific knockoutmice reveals novel expression profile andfunctions for JAM-C.Bartomeu Colom

64The role of hedgehog signalling and primary cilia inadrenal development and function.Kathryn Cogger

65Expression of ghrelin o-acyltransferase (GOAT),the ghrelin acylation enzyme, in various humantissues.Chung Thong Lim

66WNT3A modulates chondrocyte phenotypethrough activation of both canonical and non-canonical pathways.Giovanna Nalesso

67Characterization of interfollicular large B cells, anew subpopulation of B lymphocytes, in tertiarylymphoid organs in rheumatic autoimmunediseases.Elisa Corsiero

68Rheumatoid synovial fibroblasts support aidexpression and IG class-switching in B cells via abaff-dependent TLR3-stimulated pathway.Yvonne Kam

69Syndecan-2 core protein directly interacts with theprotein tyrosine phosphatase CD148/PTPRJ topromote integrin-mediated adhesion.James Whiteford

70Transient exposure of macrophages to p38 MAPKinhibition conditions cell responses through MAPKactivated protein kinase-2 (MK-2) regulation.Dr Nasser Malik

71Identification of differential binding sites forFPR2/ALX ligands and AnxA1 receptor-mediatedresponses.Stefania Bena

72Human neutrophils (PMN) migrating across thegingival crevice during acture capsaicin challengeare fully activated.Alex Speight

73Coronary artery disease related genetic variant onchromosome 10q11 is associated with carotidintima-media thickness and atherosclerosis.Ross Laxton

74Aspirin augments the anti-platelet effects of partialbut not complete P2Y12 receptor blockade.Nicholas Kirkby

75Different effects of angiotensin ii and angiotensin-(1-7) on vascular smooth muscle cell proliferationand migration.Feng Zhang



With thanks to the Barts and The LondonCharitable Foundation for their continued

support of William Harvey Day.

76Establishing 3D cultures of immortalizedchondrocytes to test anti-inflammatory andchondroprotective drugs.Karin Greco

77Involvement of autoimmunity in the pathogenesisof aggressive periodontitis.Dr Assi Hendler

78The use of a 96-well plate-based plateletaggregation methods as a replacement fortraditional light transmission aggregometry inclinical settings.Melissa Chan

79Molecular and cellular evolution of functionaltertiary lymphoid structures in salivary glands ofNOD mice: inhibition of the lymphotoxin-bpathway.Elisa Astorri

80AP214, a new aMSH analogue, possesses anti-inflammatory activities.Trinidad Montero

81Targeted cytokine intervention to arrestatherosclerosis development in vivo.Dr Sandrine Vessillier

82Targeting therapeutics to Arthritic joints.Chris Hughes

83Sequential gene expression profiles followingcardiac surgery involving cardiopulmonarybypass.Eduardo Svoren

84Engineering oligodendrocyte progenitors whosegrowth and differentiation can be controlled bydoxycycline.Alexander Annenkov

85Heightened basal immune surveillance explainssex-differences in acute inflammatory responses.Dr Ramona Scotland

86Sex specific Role for tRPV1 in pressure inducedconstriction of resistance arteries.Kristen Bubb

87The role of primary cilia mediated hedgehogsignalling in chondrocyte mechanobiology.Clare Davis

88Identification of a novel mediator capable ofdampening inflammation in vivo and enhancingphagocytosis through ChemR23.Jenna Cash

89Progenitor cells in the adrenal cortex: focus onSonic Hedgehog (Shh) and Preadipocyte Factor 1(Pref-1).Leonardo Guasti


90Identification of interacting partners via yeast-two-hybrid screening for the ataxia protein sacsin.David Parfitt

91Generation and analysis of synthetic inflammationresponsive promoters.Hodan Mohamed

92Dynamics of Melanocortin-4 Receptor processingat the endoplasmic reticulum.Nalini Ramnarace

93Why does MRAP2 fail to save FamilialGlucocorticoid Deficiency type 2 patients?Rebecca Gorrigan

94Evaluation of the interaction ofphosphodiesterases 2A and 4A5 with the arylhydrocarbon receptor interacting protein inpituitary cells.Carole Lennox

95In Silico enzyme and receptor fit screening ofdiglucopyranosylamines: a novel application fordetermining mechanism of action of novel drugcandidates.Dr Michael Seed

96Post-translational modification of type II collagen:the link between type 1 diabetes and rheumatoidarthritis.Rocky Strollo

97Development of novel recombinantbiotherapeutics for treatment of Arthritis.Tahereh Kamalati

98Anti-inflammatory effects of prednisone and acleavage-resistant form of Annexin 1 in immunecomplex-mediated Arthritis.Dr Kristin Kornerup

99Differential mobilisation of neutrophils in femalesunderlies sex-differences in ischaemia/reperfusioninjury.Shimona Madalli

100Autocrine/Paracrine CXCR1/CXCR2 signalling isrequired for the phenotypic stability of articularchondrocytes.Jo Sherwood

101Dose-dependent effects of dopexamine on indicesof shock and organ dysfunction in a rodent modelof laparotomy and endotoxaemia.Dr Mansoor Bangash

Wolfson Institute ofPreventive Medicine102Inflammation, depression and quality of life incancer patients.Miss Jo Archer



103Effect of body mass index on recurrence inhormone receptor positive early breast cancer – Aretrospective exploratory analysis from the ATACtrial.Ivana Sestak

104Down syndrome: screening and prenataldiagnosis regionally in England and Wales 1989-2008.Elizabeth De Souza and Joan Morris

105C-reactive protein in screening for coronary heartdisease.David Wald and Jon Bestwick

106Environmental Noise exposure, early biologicalrisk and mental health in 9-10 year old children: across-sectional field study.Rosanna Crombie

107How is coordination of nonverbal behaviour ininteraction influenced by the presence of a patientwith schizophrenia?Mary Lavelle

108Investigating clustering in Edwards syndrome.James Cook

109Novel diagnostic and prognostic characteristics ofDNA methylated genes and their combinations inProstate cancer.Natasa Vasiljevic

110A pilot study to assess the feasibility andacceptability of Child-parent screening for FamilialHypercholesterolaemia.Angela Godoy

111Risk screening converter – an interactive, simpleassessment tool to see whether a risk factor islikely to be a useful screening test.Joan Morris

112DNA Methylation profiling of 30 candidate genesreveals novel diagnostic biomarkers in Breastcancer.Mangesh Thorat

113The incidence of venous thromboembolism (VTE)in East London.Peter MacCallum

114Psychiatric patients’ views of involuntary hospitaladmission: a prospective study in 11 Europeancountries.Claudia Dougall

Newham University HospitalNHS Trust115Preventing Venous Thromboembolism is not a tickbox exercise.Emma Cottrell



116A review of HaN in a district general hospital bymedical students.Dr Carlo Prina

Tower Hamlets Primary Care Trust117Ethnicity specific cardiovascular risk factors inadolescents: A pilot cross-sectional comparison ofBritish South Asian and White males.Steph Hemmings

118A modelling approach to aid the understanding ofhigh volume image guided injection (HVIGI) inrecalcitrant Achilles tendinopathy.Dr Richard Twycross-Lewis

University College London119Prevalence of sequence variants inphosphodiesterase enzyme 6C (PDE6C) in 8patients with Late Onset Achromatopsia.James Berwin

Institute of Cancer120Functional and clinical significance of loss of thetumour- suppressor MMP-8 in myoepithelial cellsof DCIS.Muguet Sarper

121A schools population based study of indoor vs.outdoor exercise and the contribution of vitamin Dto fitness, health and academic performance.Lucy Battery and Professor Tim Oliver

122Meta-analysis of impact of lack of circumcisionand Vitamin D deficiency on occurrence ofprostate cancer.Professor R T D Oliver

The Blizard Institute of Celland Molecular Science123Characterising a novel animal model of thymiccarcinoma.Asad Mahmood

124Impairment of oesophageal mucosal integrity afterrepetitive exposure to weakly acidic solutions: Anin vitro model to study mechanisms of persistentsymptoms in refractory gastro-oesophageal refluxdisease.Dr Yasotha Duraisamy

125The effects of EGFR inhibition on cancer stemcells in head and neck squamous cell carcinomacell lines.Samim Ghorbanian

126Docosahexaenoic acid is neuroprotective afterspinal cord compression injury in the mouse.Siew-Na Lim



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william harvey day programme 2010

Documents

approvalwilliam harvey

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