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24/04/15 egular insulin - Wikipedia, the free encyclopedia

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Regular insulin

Clinical data

AHFS/Drugs.com monograph

MedlinePlus a682611

Legal status US:!-only

Routes of

administrationSubcutaneous, intramuscular,

intravenous

Identifiers

Chemical data

Regular insulinFrom Wikipedia, the free encyclopedia

Regular insulinincludes regular human insulinalso known

as human insulin (regular)and is a short acting insulin.[1][2]

The two most common brand names are Humulin Rand

Novolin R.[1]It is primarily used to treat high blood sugar

evels in conditions like diabetes mellitus.[2]

Contents

1 Medical uses

2 Side effects

3 Society and culture

3.1 Manufacture

3.2 Formulations

4References

Medical uses

t is used for the long term management of diabetes.[2]Regular insulin is the treatment of choice for the two

diabetic emergencies diabetic ketoacidosis and hyperosmolar hyperglycemic states.[2]It may also be used in

combination with glucose to lower potassium levels in those with hyperkalemia.[2]

Side effects

Side effects may include: low blood sugar levels, skin reactions at the site of injection and low potassium lev

among others.[2]

Society and culture

Manufacture

Humulin one brand name for a group of biosynthetic human insulin products, developed by Arthur Riggs,

working with Genentech in 1978 (Generic names regular insulin, insulin isophane and the Lente series

consisting of Lente (known generically as insulin zinc suspension) is actually a mixture of Ultralente and

Semilente) and later acquired by Eli Lilly and Company, the company who arguably facilitated the product's
http://en.wikipedia.org/wiki/Arthur_Riggs_(geneticist)http://en.wikipedia.org/wiki/Eli_Lilly_and_Companyhttp://en.wikipedia.org/wiki/Genentechhttp://en.wikipedia.org/wiki/Genentechhttp://en.wikipedia.org/wiki/Regular_insulin#Referenceshttp://en.wikipedia.org/wiki/Regular_insulin#Society_and_culturehttp://en.wikipedia.org/wiki/Route_of_administrationhttp://en.wikipedia.org/wiki/Prescription_drughttp://en.wikipedia.org/wiki/Regular_insulin#cite_note-Med2014-1http://en.wikipedia.org/wiki/Regular_insulin#cite_note-Med2014-1http://en.wikipedia.org/wiki/Regular_insulin#cite_note-AHSF2014-2http://en.wikipedia.org/wiki/Eli_Lilly_and_Companyhttp://en.wikipedia.org/wiki/Genentechhttp://en.wikipedia.org/wiki/Arthur_Riggs_(geneticist)http://en.wikipedia.org/wiki/Insulinhttp://en.wikipedia.org/wiki/Humanhttp://en.wikipedia.org/wiki/Brandhttp://en.wikipedia.org/wiki/Regular_insulin#cite_note-AHSF2014-2http://en.wikipedia.org/wiki/Hypokalemiahttp://en.wikipedia.org/wiki/Hypoglycemiahttp://en.wikipedia.org/wiki/Regular_insulin#cite_note-AHSF2014-2http://en.wikipedia.org/wiki/Hyperkalemiahttp://en.wikipedia.org/wiki/Regular_insulin#cite_note-AHSF2014-2http://en.wikipedia.org/wiki/Hyperosmolar_hyperglycemic_stateshttp://en.wikipedia.org/wiki/Diabetic_ketoacidosishttp://en.wikipedia.org/wiki/Regular_insulin#cite_note-AHSF2014-2http://en.wikipedia.org/wiki/Regular_insulin#Referenceshttp://en.wikipedia.org/wiki/Regular_insulin#Formulationshttp://en.wikipedia.org/wiki/Regular_insulin#Manufacturehttp://en.wikipedia.org/wiki/Regular_insulin#Society_and_culturehttp://en.wikipedia.org/wiki/Regular_insulin#Side_effectshttp://en.wikipedia.org/wiki/Regular_insulin#Medical_useshttp://en.wikipedia.org/wiki/Regular_insulin#cite_note-AHSF2014-2http://en.wikipedia.org/wiki/Diabetes_mellitushttp://en.wikipedia.org/wiki/Regular_insulin#cite_note-Med2014-1http://en.wikipedia.org/wiki/Regular_insulin#cite_note-AHSF2014-2http://en.wikipedia.org/wiki/Regular_insulin#cite_note-Med2014-1http://en.wikipedia.org/wiki/Route_of_administrationhttp://en.wikipedia.org/wiki/Prescription_drughttp://en.wikipedia.org/wiki/Regulation_of_therapeutic_goodshttp://www.nlm.nih.gov/medlineplus/druginfo/meds/a682611.htmlhttp://en.wikipedia.org/wiki/MedlinePlushttp://www.drugs.com/monograph/insulin_human.htmlhttp://en.wikipedia.org/wiki/Drugs.comhttp://en.wikipedia.org/wiki/American_Society_of_Health-System_Pharmacists


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approval with the U.S. Food and Drug Administration. The Lente series was discontinued by Lilly in 2005.

Prior to the development of synthesized human insulin, patients were dependent on animal insulin which wa

more costly, less accessible, and caused infections in some patients.

Humulin is synthesized in a laboratory strain of Escherichia coli bacteria which has been genetically altered

with recombinant DNA to produce biosynthetic human insulin. Humulin R consists of zinc-insulin crystals

dissolved in a clear fluid. The synthesized insulin is then combined with other compounds or types of insulin

which affect its shelf life and absorption. For example, Humulin N is combined with protamine to extend the

ime-activity profile of Humulin R for an extended period.

Formulations

t is currently sold by Eli Lilly under different types:

Humulin R (REGULAR human insulin injection [rDNA origin]) is a short-acting insulin that has a

relatively short duration of activity as compared with other insulins.

Humulin R Regular U-500 (Concentrated) insulin human injection, USP (rDNA Origin) is a strongerconcentration (500 units/mL) of Humulin R.

Humulin N (human NPH insulin injection [rDNA origin]) is an intermediate-acting insulin with a slow

onset of action and a longer duration of activity than Humulin R.

Humulin 70/30 (70% human insulin isophane suspension, 30% human insulin injection [rDNA origin]

a mixture insulin. It is an intermediate-acting insulin combined with the onset of action of Humulin

Humulin 50/50 (50% human insulin isophane suspension, 50% human insulin injection [rDNA origin]

a mixture insulin. It is an intermediate-acting insulin combined with the onset of action of Humulin R.

Humulin is identical in chemical structure to human insulin.

References

1. "insulin regular human (OTC) - Humulin R, Novolin R" (http://reference.medscape.com/drug/humulin-r-novolin-r-

insulin-regular-human-999007). Retrieved 1 December 2014.

2. "Insulin Human" (http://www.drugs.com/monograph/insulin-human.html). www.drugs.com. Retrieved 1 December 2

Retrieved from "http://en.wikipedia.org/w/index.php?title=Regular_insulin&oldid=656447800"

Categories: Eli Lilly and Company Insulin therapies Human proteins

This page was last modified on 14 April 2015, at 15:04.
http://en.wikipedia.org/wiki/Help:Categoryhttp://en.wikipedia.org/w/index.php?title=Regular_insulin&oldid=656447800http://www.drugs.com/monograph/insulin-human.htmlhttp://reference.medscape.com/drug/humulin-r-novolin-r-insulin-regular-human-999007http://en.wikipedia.org/wiki/NPH_insulinhttp://en.wikipedia.org/wiki/Recombinant_DNAhttp://en.wikipedia.org/wiki/Escherichia_colihttp://en.wikipedia.org/wiki/Category:Human_proteinshttp://en.wikipedia.org/wiki/Category:Insulin_therapieshttp://en.wikipedia.org/wiki/Category:Eli_Lilly_and_Company


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