wikipedia - milroy's disease (for check)
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7/9/15, 23:21Milroy's disease - Wikipedia, the free encyclopedia
Page 1 of 2https://en.wikipedia.org/wiki/Milroy%27s_disease
Milroy's diseaseClassification and external resources
ICD-10 Q82.0(http://apps.who.int/classifications/icd10/browse/2015/en#/Q82.0)
ICD-9-CM 757.0 (http://www.icd9data.com/getICD9Code.ashx?icd9=757.0)
OMIM 153100 (http://omim.org/entry/153100)
DiseasesDB 8228 (http://www.diseasesdatabase.com/ddb8228.htm)
eMedicine med/1482 (http://www.emedicine.com/med/topic1482.htm)
MeSH D008209 (https://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?field=uid&term=D008209)
GeneReviews Milroy Disease(http://www.ncbi.nlm.nih.gov/books/NBK1239/)
Milroy's diseaseFrom Wikipedia, the free encyclopedia
Milroy's disease is a familialdisease characterized bylymphedema, commonly in the legs,caused by congenital abnormalitiesin the lymphatic system. Disruptionof the normal drainage of lymphleads to fluid accumulation andhypertrophy of soft tissues.[1][2] It isalso known as Milroy disease,Nonne-Milroy-Meige syndromeand hereditary lymphedema.[3]
It was named by Sir William Oslerfor William Milroy, an Americanphysician, who described a case in1892, though it was first describedby Rudolf Virchow in 1863.[4][5]
Contents1 Description2 See also3 References4 External links
DescriptionThe most common presentation of Milroy Disease is bilateral lower extremity lymphedema, and may also beaccompanied by hydrocele.[6]
This disease is more common in women and an association with the gene FLT4 has been described.[7] FLT4codes for VEGFR-3, which is implicated in development of the lymphatic system.
See alsoList of cutaneous conditions
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7/9/15, 23:21Milroy's disease - Wikipedia, the free encyclopedia
Page 2 of 2https://en.wikipedia.org/wiki/Milroy%27s_disease
References1. James, William D.; Berger, Timothy G.; et al. (2006). Andrews' Diseases of the Skin: clinical Dermatology. Saunders
Elsevier. p. 849. ISBN 0-7216-2921-0.2. David Lowell Strayer; Raphael Rubin (2007). Rubin's Pathology: Clinicopathologic Foundations of Medicine 5th
Edition. Hagerstwon, MD: Lippincott Williams & Wilkins. ISBN 0-7817-9516-8.3. Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. ISBN 1-
4160-2999-0.4. synd/1326 (http://www.whonamedit.com/synd.cfm/1326.html) at Who Named It?5. W. F. Milroy. An undescribed variety of herditary edema. New York Medical Journal, 1892, 56: 505-508.6. "Milroy Disease" (http://ghr.nlm.nih.gov/condition/milroy-disease). United States Library of Medicine. Retrieved March
2014.7. Spiegel R, Ghalamkarpour A, Daniel-Spiegel E, Vikkula M, Shalev SA (2006). "Wide clinical spectrum in a family with
hereditary lymphedema type I due to a novel missense mutation in VEGFR3". Journal of Human Genetics 51 (10): 846–50. doi:10.1007/s10038-006-0031-3 (https://dx.doi.org/10.1007%2Fs10038-006-0031-3). PMID 16924388(https://www.ncbi.nlm.nih.gov/pubmed/16924388).
External linksGeneReview/NIH/UW entry on Milroy Disease (http://www.ncbi.nlm.nih.gov/books/NBK1239/)
Retrieved from "https://en.wikipedia.org/w/index.php?title=Milroy%27s_disease&oldid=603676792"
Categories: Ailments of unknown etiology Vascular-related cutaneous conditions
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